|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
3-400 |
1.12e-160 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 457.24 E-value: 1.12e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 3 LLPVEQALEQIFSRIPAPTPETVPLAEANGRTLVAPLLAAHSQPPFNASAMDGYAVRAADFAEDATRSVQLVGVSQAGHG 82
Cdd:COG0303 1 MISVEEALALILAAVRPLGTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGANPVTLRVVGEIAAGSP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 83 FAGTLQPGQAVRIFTGAPVPQGADCVIMQELATASDGAVKFSERPTAGRSIRPTGNDFRSGAELLATGTRLTPYSLALAA 162
Cdd:COG0303 81 PPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 163 AANAPTLTVAKRPAISVLATGDELVLPGAALAPDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAASLEQALA-AD 241
Cdd:COG0303 161 SLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALREALAeAD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 242 IVVTTGGASVGDHDIVQDVLKELGVEIDFWRINMRPGKPLMFGTRGSTLVFGLPGNPVSAMVTATVFLLPALRRWLGDAN 321
Cdd:COG0303 241 LVITSGGVSVGDYDLVKEALEELGAEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLPP 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 901897056 322 PLGARLSLPLADPLPANTARRHFQRATIETSGtGVTQVRPISETDSGHTSSLARAQALIVQPENDPGQPVGATVEVIPL 400
Cdd:COG0303 321 PPPPRVRARLAEDLPKKPGRTEFLRVRLERDD-GELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGVEAGEEVEVLLL 398
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
6-400 |
2.09e-152 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 436.15 E-value: 2.09e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 6 VEQALEQIFSRIPAPTPETVPLAEANGRTLVAPLLAAHSQPPFNASAMDGYAVRAADFAeDATRSVQLVGVSQAGHGFAG 85
Cdd:cd00887 1 VEAARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTA-GASVTLRVVGEIPAGEPPDG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 86 TLQPGQAVRIFTGAPVPQGADCVIMQELATASDGAVKFSERPTAGRSIRPTGNDFRSGAELLATGTRLTPYSLALAAAAN 165
Cdd:cd00887 80 PLGPGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 166 APTLTVAKRPAISVLATGDELVLPGAALAPDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAASLEQALA-ADIVV 244
Cdd:cd00887 160 IAEVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEeADVVI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 245 TTGGASVGDHDIVQDVLKELGVEIDFWRINMRPGKPLMFGTRGSTLVFGLPGNPVSAMVTATVFLLPALRRWLGDANPLG 324
Cdd:cd00887 240 TSGGVSVGDYDFVKEVLEELGGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEP 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 901897056 325 ARLSLPLADPLPANTARRHFQRATIETSGtGVTQVRPISETDSGHTSSLARAQALIVQPENDPGQPVGATVEVIPL 400
Cdd:cd00887 320 PRVKARLAEDLKSKPGRREFLRVRLERDE-GGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGLEAGEEVEVLLL 394
|
|
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
4-400 |
6.29e-107 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 326.96 E-value: 6.29e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 4 LPVEQALEQIFSRI-PAPTPETVPLAEANGRTLVAPLLAAHSQPPFNASAMDGYAVRAADFAEDatrSVQLVGVSQAGHG 82
Cdd:PRK14491 199 LSVSQGLDKILSLVtPVTETEDVALDELDGRVLAQDVISPVNVPQHTNSAMDGYAFRSDDLEPE---SYTLVGEVLAGHQ 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 83 FAGTLQPGQAVRIFTGAPVPQGADCVIMQELATASDGAVKFSERPTAGRSIRPTGNDFRSGAELLATGTRLTPYSLALAA 162
Cdd:PRK14491 276 YDGTLQAGEAVRIMTGAPVPAGADTVVMRELATQDGDKVSFDGGIKAGQNVRLAGEDLAQGQVALAAGTRLSAPEQGLLA 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 163 AANAPTLTVAKRPAISVLATGDELVLPGAALAPDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAASLEQALA-AD 241
Cdd:PRK14491 356 SLGFAEVPVFRRPKVAVFSTGDEVQAPGETLKPNCIYDSNRFTIKAMAKKLGCEVIDLGIIEDSEAALEATLEQAAAqAD 435
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 242 IVVTTGGASVGDHDIVQDVLKELGvEIDFWRINMRPGKPLMFGTRGSTLVFGLPGNPVSAMVTATVFLLPALRRWLGDAN 321
Cdd:PRK14491 436 VVISSGGVSVGDADYIKTALAKLG-QIDFWRINMRPGRPLAFGQIGDSPFFGLPGNPVAVMVSFLQFVEPALRKLAGEQN 514
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 901897056 322 PLGARLSLPLADPLPANTARRHFQRATIETSGTGVTQVRPISETDSGHTSSLARAQALIVQPENDPGQPVGATVEVIPL 400
Cdd:PRK14491 515 WQPLLFPAIADETLRSRQGRTEFSRGIYHLGADGRLHVRTTGKQGSGILSSMSEANCLIEIGPAAETVNAGETVTIQPL 593
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
17-156 |
1.06e-39 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 138.47 E-value: 1.06e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 17 IPAPTPETVPL--AEANGRTLVAPLLAAHSQPPFNASAMDGYAVRAADfaedaTRSVQLVGVSQAGHGFAGTLQPGQAVR 94
Cdd:pfam03453 1 PLLGTEETVPLeaLDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAAD-----GFGASEVNPIAAGEPPGPLLPGGEAVR 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 901897056 95 IFTGAPVPQGADCVIMQELATASDGAVKFSERPTA-GRSIRPTGNDFRSGAELLATGTRLTPY 156
Cdd:pfam03453 76 IMTGAPLPEGADAVVMVEDTEEGGGRTVEIRAPVApGENVRRAGEDIKAGEVVLPAGTRLTPA 138
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
175-311 |
2.55e-31 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 116.26 E-value: 2.55e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 175 PAISVLATGDELVLPGAALAPDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAASLEQALA-ADIVVTTGGASVGD 253
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDeADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 901897056 254 HDIVQDVLKELG-VEID---------FWRINMRPGKPLMFGTRGSTLVFGLPGNPVSAMVTATVFLLP 311
Cdd:TIGR00177 81 RDVTPEALEELGeKEIPgfgefrmlsSLPVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
179-304 |
1.47e-28 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 108.83 E-value: 1.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 179 VLATGDELVLPGaalapdQIVASNSFGLVPLLAPFASQVRDLGIA--RDDASALAASLEQALA-ADIVVTTGGASVGDHD 255
Cdd:smart00852 2 IISTGDELLSGG------QIRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAeADVVITTGGTGPGPDD 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 901897056 256 IVQDVLKE-LGVEIDFWRINMRPGKPLMF---------GTRGSTLVFGLPGNPVSAMVT 304
Cdd:smart00852 76 LTPEALAElGGRELLGHGVAMRPGGPPGPlanlsgtapGVRGKKPVFGLPGNPVAALVM 134
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
3-400 |
1.12e-160 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 457.24 E-value: 1.12e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 3 LLPVEQALEQIFSRIPAPTPETVPLAEANGRTLVAPLLAAHSQPPFNASAMDGYAVRAADFAEDATRSVQLVGVSQAGHG 82
Cdd:COG0303 1 MISVEEALALILAAVRPLGTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGANPVTLRVVGEIAAGSP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 83 FAGTLQPGQAVRIFTGAPVPQGADCVIMQELATASDGAVKFSERPTAGRSIRPTGNDFRSGAELLATGTRLTPYSLALAA 162
Cdd:COG0303 81 PPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAGTRLTPADLGLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 163 AANAPTLTVAKRPAISVLATGDELVLPGAALAPDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAASLEQALA-AD 241
Cdd:COG0303 161 SLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRAALREALAeAD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 242 IVVTTGGASVGDHDIVQDVLKELGVEIDFWRINMRPGKPLMFGTRGSTLVFGLPGNPVSAMVTATVFLLPALRRWLGDAN 321
Cdd:COG0303 241 LVITSGGVSVGDYDLVKEALEELGAEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLAGLPP 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 901897056 322 PLGARLSLPLADPLPANTARRHFQRATIETSGtGVTQVRPISETDSGHTSSLARAQALIVQPENDPGQPVGATVEVIPL 400
Cdd:COG0303 321 PPPPRVRARLAEDLPKKPGRTEFLRVRLERDD-GELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGVEAGEEVEVLLL 398
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
6-400 |
2.09e-152 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 436.15 E-value: 2.09e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 6 VEQALEQIFSRIPAPTPETVPLAEANGRTLVAPLLAAHSQPPFNASAMDGYAVRAADFAeDATRSVQLVGVSQAGHGFAG 85
Cdd:cd00887 1 VEAARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTA-GASVTLRVVGEIPAGEPPDG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 86 TLQPGQAVRIFTGAPVPQGADCVIMQELATASDGAVKFSERPTAGRSIRPTGNDFRSGAELLATGTRLTPYSLALAAAAN 165
Cdd:cd00887 80 PLGPGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGLLASLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 166 APTLTVAKRPAISVLATGDELVLPGAALAPDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAASLEQALA-ADIVV 244
Cdd:cd00887 160 IAEVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEeADVVI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 245 TTGGASVGDHDIVQDVLKELGVEIDFWRINMRPGKPLMFGTRGSTLVFGLPGNPVSAMVTATVFLLPALRRWLGDANPLG 324
Cdd:cd00887 240 TSGGVSVGDYDFVKEVLEELGGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGAPEPEP 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 901897056 325 ARLSLPLADPLPANTARRHFQRATIETSGtGVTQVRPISETDSGHTSSLARAQALIVQPENDPGQPVGATVEVIPL 400
Cdd:cd00887 320 PRVKARLAEDLKSKPGRREFLRVRLERDE-GGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGLEAGEEVEVLLL 394
|
|
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
4-400 |
6.29e-107 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 326.96 E-value: 6.29e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 4 LPVEQALEQIFSRI-PAPTPETVPLAEANGRTLVAPLLAAHSQPPFNASAMDGYAVRAADFAEDatrSVQLVGVSQAGHG 82
Cdd:PRK14491 199 LSVSQGLDKILSLVtPVTETEDVALDELDGRVLAQDVISPVNVPQHTNSAMDGYAFRSDDLEPE---SYTLVGEVLAGHQ 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 83 FAGTLQPGQAVRIFTGAPVPQGADCVIMQELATASDGAVKFSERPTAGRSIRPTGNDFRSGAELLATGTRLTPYSLALAA 162
Cdd:PRK14491 276 YDGTLQAGEAVRIMTGAPVPAGADTVVMRELATQDGDKVSFDGGIKAGQNVRLAGEDLAQGQVALAAGTRLSAPEQGLLA 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 163 AANAPTLTVAKRPAISVLATGDELVLPGAALAPDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAASLEQALA-AD 241
Cdd:PRK14491 356 SLGFAEVPVFRRPKVAVFSTGDEVQAPGETLKPNCIYDSNRFTIKAMAKKLGCEVIDLGIIEDSEAALEATLEQAAAqAD 435
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 242 IVVTTGGASVGDHDIVQDVLKELGvEIDFWRINMRPGKPLMFGTRGSTLVFGLPGNPVSAMVTATVFLLPALRRWLGDAN 321
Cdd:PRK14491 436 VVISSGGVSVGDADYIKTALAKLG-QIDFWRINMRPGRPLAFGQIGDSPFFGLPGNPVAVMVSFLQFVEPALRKLAGEQN 514
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 901897056 322 PLGARLSLPLADPLPANTARRHFQRATIETSGTGVTQVRPISETDSGHTSSLARAQALIVQPENDPGQPVGATVEVIPL 400
Cdd:PRK14491 515 WQPLLFPAIADETLRSRQGRTEFSRGIYHLGADGRLHVRTTGKQGSGILSSMSEANCLIEIGPAAETVNAGETVTIQPL 593
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
2-397 |
3.73e-85 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 271.70 E-value: 3.73e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 2 SLLPVEQALEQIFSRIPAPT--PETVPLAEANGRTLVAPLLAAHSQPPFNASAMDGYAVRAAD-FA--EDATRSVQLVGV 76
Cdd:PRK14498 8 TLVSLEEAREILESLLSELPlgTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAVRAADtFGasEANPVRLKLGGE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 77 SQAGHGFAGTLQPGQAVRIFTGAPVPQGADCVIMQE-LATASDGAVKFsERPTA-GRSIRPTGNDFRSGAELLATGTRLT 154
Cdd:PRK14498 88 VHAGEAPDVEVEPGEAVEIATGAPIPRGADAVVMVEdTEEVDDDTVEI-YRPVApGENVRPAGEDIVAGELILPKGTRLT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 155 PYSLALAAAANAPTLTVAKRPAISVLATGDELVLPGAALAPDQIVASNSfglvpllAPFASQVRDLG-------IARDDA 227
Cdd:PRK14498 167 PRDIGALAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNS-------YTLAAAVEEAGgepvrygIVPDDE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 228 SALAASLEQALA-ADIVVTTGGASVGDHDIVQDVLKELGvEIDFWRINMRPGKPLMFGTRGSTLVFGLPGNPVSAMVTAT 306
Cdd:PRK14498 240 EELEAALRKALKeCDLVLLSGGTSAGAGDVTYRVIEELG-EVLVHGVAIKPGKPTILGVIGGKPVVGLPGYPVSALTIFE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 307 VFLLPALRRWLGDANPLGARLSLPLADPLPANTARRHFQRATIETSGTGVTqVRPISeTDSGHTSSLARAQALIVQPEND 386
Cdd:PRK14498 319 EFVAPLLRKLAGLPPPERATVKARLARRVRSELGREEFVPVSLGRVGDGYV-AYPLS-RGSGAITSLVRADGFIEIPANT 396
|
410
....*....|.
gi 901897056 387 PGQPVGATVEV 397
Cdd:PRK14498 397 EGLEAGEEVEV 407
|
|
| PRK10680 |
PRK10680 |
molybdopterin biosynthesis protein MoeA; Provisional |
3-399 |
7.16e-84 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 182643 [Multi-domain] Cd Length: 411 Bit Score: 261.95 E-value: 7.16e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 3 LLPVEQALEQIFSRI-PAPTPETVPLAEANGRTLVAPLLAAHSQPPFNASAMDGYAVRAADFAEDATRSVqlVGVSQAGH 81
Cdd:PRK10680 7 LMSLETALTEMLSRVtPLTATETLPLVQCFGRITASDIVSPLDVPGFDNSAMDGYAVRLADLASGQPLPV--AGKAFAGQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 82 GFAGTLQPGQAVRIFTGAPVPQGADCVIMQELATASDGAVKFSERPTAGRSIRPTGNDFRSGAELLATGTRLTPYSLALA 161
Cdd:PRK10680 85 PFHGEWPAGTCIRIMTGAPVPEGCEAVVMQEQTEQTDDGVRFTAEVRSGQNIRRRGEDISQGAVVFPAGTRLTTAELPVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 162 AAANAPTLTVAKRPAISVLATGDELVLPGAALAPDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAASLEQA-LAA 240
Cdd:PRK10680 165 ASLGIAEVPVVRKVRVALFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLEQLGCEVINLGIIRDDPHALRAAFIEAdSQA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 241 DIVVTTGGASVGDHDIVQDVLKELGvEIDFWRINMRPGKPLMFGTRGSTLVFGLPGNPVSAMVTATVFLLPALRRWLGDA 320
Cdd:PRK10680 245 DVVISSGGVSVGEADYTKTILEELG-EIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSAALTFYQLVQPLLAKLSGNT 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 321 NP-LGARLSLPLADPLPANTARRHFQRATIETSGTGVTQVRPISETDSGHTSSLARAQALIVQpENDPGQ-PVGATVEVI 398
Cdd:PRK10680 324 ASgLPPRQRVRTASRLKKTPGRLDFQRGILQRNADGELEVTTTGHQGSHIFSSFSLGNCFIVL-ERERGNvEVGEWVEVE 402
|
.
gi 901897056 399 P 399
Cdd:PRK10680 403 P 403
|
|
| PLN02699 |
PLN02699 |
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase |
2-350 |
1.64e-64 |
|
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
Pssm-ID: 215376 [Multi-domain] Cd Length: 659 Bit Score: 217.76 E-value: 1.64e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 2 SLLPVEQALEQIFSRIPAPTPETVPLAEANGRTLVAPLLAAHSQPPFNASAMDGYAVRAADFAEDatrsVQLVGVSQAGH 81
Cdd:PLN02699 6 EMISVEEALSIVLSVAARLSPVIVPLHEALGKVLAEDIRAPDPLPPYPASVKDGYAVVASDGPGE----YPVITESRAGN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 82 -GFAGTLQPGQAVRIFTGAPVPQGADCVIMQE-LATASDGA-----VKFSERPTAGRSIRPTGNDFRSGAELLATGTRLT 154
Cdd:PLN02699 82 dGLGVTLTPGTVAYVTTGGPIPDGADAVVQVEdTEVVEDPLdgskrVRILSQASKGQDIRPVGCDIEKDAKVLKAGERLG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 155 PYSLALAAAANAPTLTVAKRPAISVLATGDELVLPGAA-LAPDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAAS 233
Cdd:PLN02699 162 ASEIGLLATVGVTMVKVYPRPTVAILSTGDELVEPTTGtLGRGQIRDSNRAMLLAAAIQQQCKVVDLGIARDDEEELERI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 234 LEQALAA--DIVVTTGGASVGDHDIVQDVLKELGvEIDFWRINMRPGKPLMF---------GTRGSTLVFGLPGNPVSAM 302
Cdd:PLN02699 242 LDEAISSgvDILLTSGGVSMGDRDFVKPLLEKRG-TVYFSKVLMKPGKPLTFaeidaksapSNSKKMLAFGLPGNPVSCL 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 901897056 303 VTATVFLLPALRRWLGDANPLGARLSLPLADPLPANTARRHFQRATIE 350
Cdd:PLN02699 321 VCFNLFVVPAIRYLAGWSNPHLLRVQARLREPIKLDPVRPEFHRAIIR 368
|
|
| PRK14690 |
PRK14690 |
molybdopterin biosynthesis protein MoeA; Provisional |
5-391 |
4.77e-59 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 237789 [Multi-domain] Cd Length: 419 Bit Score: 197.83 E-value: 4.77e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 5 PVEQALEQIFSRI-PAPTPETVPLAEANGRTLVAPLLAAHSQPPFNASAMDGYAvraadFAEDATRSVQLV----GVSQA 79
Cdd:PRK14690 24 PVDTALDLLRARLgPVTDIKELDLSDALGHVLAHDAVALRSNPPQANSAVDGYG-----FAGAAPEGAQVLplieGRAAA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 80 GHGFAGTLQPGQAVRIFTGAPVPQGADCVIMQELATASDGAVKFSERPTAGRSIRPTGNDFRSGAELLATGTRLTPYSLA 159
Cdd:PRK14690 99 GVPFSGRVPEGMALRILTGAALPEGVDTVVLEEDVAGDGHRIAFHGPLKMGANTRKAGEDVIAGDVALPAGRRLTPADLA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 160 LAAAANAPTLTVAKRPAISVLATGDELVLPGAALAPDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAASLEQALA 239
Cdd:PRK14690 179 LLSAVGLTRVSVRRPLRVAVLSTGDELVEPGALAEVGQIYDANRPMLLALARRWGHAPVDLGRVGDDRAALAARLDRAAA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 240 -ADIVVTTGGASVGDHDIVQDVLKELGVeIDFWRINMRPGKPLMFGTRGSTLVFGLPGNPVSAMVTATVFLLPALRRWLG 318
Cdd:PRK14690 259 eADVILTSGGASAGDEDHVSALLREAGA-MQSWRIALKPGRPLALGLWQGVPVFGLPGNPVAALVCTLVFARPAMSLLAG 337
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 901897056 319 DANPLGARLSLPLADPLPANTARRHFQRATIeTSGtgvtQVRPISETDSGHTSSLARAQALIVQPEN----DPGQPV 391
Cdd:PRK14690 338 EGWSEPQGFTVPAAFEKRKKPGRREYLRARL-RQG----HAEVFRSEGSGRISGLSWAEGLVELGDGarriAPGDPV 409
|
|
| PRK14497 |
PRK14497 |
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional |
2-333 |
6.85e-48 |
|
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional
Pssm-ID: 172968 [Multi-domain] Cd Length: 546 Bit Score: 171.15 E-value: 6.85e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 2 SLLPVEQALEQIFSRIPaPTPET--VPLAEANGRTLVAPLLAAHSQPPFNASAMDGYAVRAADFAEDATrsvqLVGVSQA 79
Cdd:PRK14497 9 SLYSIDEAIKVFLSSLN-FKPKIvkVEVKDSFGYVSAEDLMSPIDYPPFSRSTVDGYALKSSCTPGEFK----VIDKIGI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 80 GHGFAGTLQPGQAVRIFTGAPVPQGADCVIMQELATASDG-AVKFSERPTAGRSIRPTGNDFRSGAELLATGTRLTPYSL 158
Cdd:PRK14497 84 GEFKEIHIKECEAVEVDTGSMIPMGADAVIKVENTKVINGnFIKIDKKINFGQNIGWIGSDIPKGSIILRKGEVISHEKI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 159 ALAAAANAPTLTVAKRPAISVLATGDELVLPGAALAPDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAASLEQAL 238
Cdd:PRK14497 164 GLLASLGISSVKVYEKPKIYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKSEGYKIVGLSLLSDDKESIKNEIKRAI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 239 A-ADIVVTTGGASVGDHDIVQDVLKELGvEIDFWRINMRPGKPLMFGTRGSTLVFGLPGNPVSAMVTATVFL------LP 311
Cdd:PRK14497 244 SvADVLILTGGTSAGEKDFVHQAIRELG-NIIVHGLKIKPGKPTILGIVDGKPVIGLPGNIVSTMVVLNMVIleylksLY 322
|
330 340
....*....|....*....|...
gi 901897056 312 ALRRWLGDANPLGARLSLPL-AD 333
Cdd:PRK14497 323 PSRKEILGLGKIKARLALRVkAD 345
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
17-156 |
1.06e-39 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 138.47 E-value: 1.06e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 17 IPAPTPETVPL--AEANGRTLVAPLLAAHSQPPFNASAMDGYAVRAADfaedaTRSVQLVGVSQAGHGFAGTLQPGQAVR 94
Cdd:pfam03453 1 PLLGTEETVPLeaLDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAAD-----GFGASEVNPIAAGEPPGPLLPGGEAVR 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 901897056 95 IFTGAPVPQGADCVIMQELATASDGAVKFSERPTA-GRSIRPTGNDFRSGAELLATGTRLTPY 156
Cdd:pfam03453 76 IMTGAPLPEGADAVVMVEDTEEGGGRTVEIRAPVApGENVRRAGEDIKAGEVVLPAGTRLTPA 138
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
175-311 |
2.55e-31 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 116.26 E-value: 2.55e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 175 PAISVLATGDELVLPGAALAPDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAASLEQALA-ADIVVTTGGASVGD 253
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDeADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 901897056 254 HDIVQDVLKELG-VEID---------FWRINMRPGKPLMFGTRGSTLVFGLPGNPVSAMVTATVFLLP 311
Cdd:TIGR00177 81 RDVTPEALEELGeKEIPgfgefrmlsSLPVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoCF_biosynth |
pfam00994 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
179-315 |
3.02e-29 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.
Pssm-ID: 425979 [Multi-domain] Cd Length: 143 Bit Score: 110.80 E-value: 3.02e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 179 VLATGDELVlpgaalaPDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAASLEQALA-ADIVVTTGGASVGDHDIV 257
Cdd:pfam00994 2 IITTGDELL-------PGQIRDTNGPLLAALLREAGAEVIRYGIVPDDPEAIKEALRAAAEeADVVITTGGTGPGPDDVT 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 901897056 258 QDVLKELG------VEIDFWRINMRPGKPLMFGT-----RGSTLVFGLPGNPVSAMVTATVFLLPALRR 315
Cdd:pfam00994 75 PEALAELGgrelpgFEELFRGVSLKPGKPVGTAPgailsRAGKTVFGLPGSPVAAKVMFELLLLPLLRH 143
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
179-304 |
1.47e-28 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 108.83 E-value: 1.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 179 VLATGDELVLPGaalapdQIVASNSFGLVPLLAPFASQVRDLGIA--RDDASALAASLEQALA-ADIVVTTGGASVGDHD 255
Cdd:smart00852 2 IISTGDELLSGG------QIRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAeADVVITTGGTGPGPDD 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 901897056 256 IVQDVLKE-LGVEIDFWRINMRPGKPLMF---------GTRGSTLVFGLPGNPVSAMVT 304
Cdd:smart00852 76 LTPEALAElGGRELLGHGVAMRPGGPPGPlanlsgtapGVRGKKPVFGLPGNPVAALVM 134
|
|
| MoCF_BD |
cd00758 |
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ... |
177-313 |
2.32e-22 |
|
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.
Pssm-ID: 238387 [Multi-domain] Cd Length: 133 Bit Score: 91.64 E-value: 2.32e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 177 ISVLATGDELVLpgaalapDQIVASNSFGLVPLLAPFASQVRDLGIARDDASALAASLEQAL-AADIVVTTGGASVGDHD 255
Cdd:cd00758 2 VAIVTVSDELSQ-------GQIEDTNGPALEALLEDLGCEVIYAGVVPDDADSIRAALIEASrEADLVLTTGGTGVGRRD 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 901897056 256 IVQDVLKELG-VEIDFWRINMRPGKPLMFGTRGSTLVFGLPGNPVSAMVTATVFLLPAL 313
Cdd:cd00758 75 VTPEALAELGeREAHGKGVALAPGSRTAFGIIGKVLIINLPGSPKSALTTFEALVLPAL 133
|
|
| MoeA_C |
pfam03454 |
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis ... |
329-400 |
1.60e-11 |
|
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known and forms an incomplete beta barrel.
Pssm-ID: 460924 [Multi-domain] Cd Length: 72 Bit Score: 59.55 E-value: 1.60e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 901897056 329 LPLADPLPANTARRHFQRATIETSGTGVTqVRPISETDSGHTSSLARAQALIVQPENDPGQPVGATVEVIPL 400
Cdd:pfam03454 2 ARLARDLKSDPGRREFVRVRLHEEDGRYY-AEPIGKQGSGMLSSLAEANGLIVVPEGTEGLEAGEEVEVILL 72
|
|
| MoeA_like |
cd03522 |
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in ... |
210-313 |
1.90e-07 |
|
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is unknown.
Pssm-ID: 239599 Cd Length: 312 Bit Score: 52.16 E-value: 1.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 210 LAPFASQVRDLGIARDDASALAASLEQALA--ADIVVTTGGASVGDHDIVQDVLKELGVEIDFWRINMRPGKPLMFGTRG 287
Cdd:cd03522 188 LAALGVELVEQVIVPHDEAAIAAAIAEALEagAELLILTGGASVDPDDVTPAAIRAAGGEVIRYGMPVDPGNLLLLGYLG 267
|
90 100
....*....|....*....|....*.
gi 901897056 288 STLVFGLPGNPVSAMVTATVFLLPAL 313
Cdd:cd03522 268 GVPVIGLPGCARSPKLNGFDLVLPRL 293
|
|
| cinA |
cd00885 |
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon ... |
177-248 |
4.95e-05 |
|
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, where the domain is presumed to bind molybdopterin.
Pssm-ID: 238450 [Multi-domain] Cd Length: 170 Bit Score: 43.63 E-value: 4.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 177 ISVLATGDELvLPGaalapdQIVASNSFGLvpllapfASQVRDLGIA-------RDDASALAASLEQALA-ADIVVTTGG 248
Cdd:cd00885 2 AEIIAIGDEL-LSG------QIVDTNAAFL-------AKELAELGIEvyrvtvvGDDEDRIAEALRRASErADLVITTGG 67
|
|
| MoaB |
COG0521 |
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin ... |
222-313 |
8.15e-05 |
|
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin biosynthesis enzyme MoaB/MogA is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440287 [Multi-domain] Cd Length: 169 Bit Score: 42.80 E-value: 8.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 222 IARDDASALAASLEQALA---ADIVVTTGGASVGDHDI----VQDVL-KEL-GVEIDFWRINMRPGKPLMF------GTR 286
Cdd:COG0521 50 IVPDDKDAIRAALRELIDdegVDLVLTTGGTGLSPRDVtpeaTRPLLdKELpGFGELFRALSLEEIGPSAIlsravaGIR 129
|
90 100
....*....|....*....|....*..
gi 901897056 287 GSTLVFGLPGNPvSAMVTATVFLLPAL 313
Cdd:COG0521 130 GGTLIFNLPGSP-GAVREALEAILPEL 155
|
|
| MogA_MoaB |
cd00886 |
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum ... |
222-313 |
4.33e-04 |
|
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.
Pssm-ID: 238451 [Multi-domain] Cd Length: 152 Bit Score: 40.54 E-value: 4.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901897056 222 IARDDASALAASLEQALA---ADIVVTTGGASVGDHDIVQDVLKEL------GVEIDFWRINMRPGKPLMF-----GTRG 287
Cdd:cd00886 41 IVPDDKDEIREALIEWADedgVDLILTTGGTGLAPRDVTPEATRPLldkelpGFGEAFRALSLEETGTAMLsravaGIRG 120
|
90 100
....*....|....*....|....*.
gi 901897056 288 STLVFGLPGNPvSAMVTATVFLLPAL 313
Cdd:cd00886 121 GTLIFNLPGSP-KAVREALEVILPEL 145
|
|
| |
