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Conserved domains on  [gi|896441666|ref|WP_049372311|]
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transglycosylase domain-containing protein [Staphylococcus epidermidis]

Protein Classification

transglycosylase domain-containing protein( domain architecture ID 11432910)

transglycosylase domain-containing protein catalyzes the polymerization of murein glycan chains; such as biosynthetic peptidoglycan transglycosylase and bifunctional penicillin-binding proteins

CATH:  3.40.710.10|1.10.3810.10
CAZY:  GT51
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0071555|GO:0008955|GO:0009252|GO:0008360
PubMed:  8830253
SCOP:  4002510

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 52-686 0e+00

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 564.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  52 FAYYAWKAPAFSE-SKLDDPIPAKIYDKNGELVKTLdNGQRHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGA 130
Cdd:COG0744   34 VALYVADLPDPEElEDLALPQTSTIYDRDGTLIATL-GDENREWVPLDQIPPHLKDAVVAIEDRRFYEHGGVDPKGIARA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 131 IGKNLTGGFGSQGASTLTQQVVKDSFLTQQKSIGRKAQEAYLSYRLEQEYSKDEIFQVYMNKIYYSDGVTGIKAAAKYYF 210
Cdd:COG0744  113 LVANLTAGGVVQGGSTITQQLVKNLFLSNERTLSRKLKEALLALKLERKYSKDEILELYLNTVYFGRGAYGIEAAAQYYF 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 211 NKDMKDLNLAEEAYLAGLPQVPNLYNIYNNPKEANNRKDTVLYLMHKHNRINDKQYADAKKIDLKANlvertkkerQVTG 290
Cdd:COG0744  193 GKSASDLTLAEAALLAGLVKAPSYYDPYRNPEAAKERRNLVLDRMVEQGYITQAEADAAKAEPLTLV---------PPPN 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 291 NEKNPEYDSYVNFVQSELMNNkyFKDKNLgsvLQSGIKIYTNMDKDVQQTLQDRINNG-SFYKNEDQQVGATILDSKTGG 369
Cdd:COG0744  264 GAAAGKYPYFVDYVRRELEEL--LGEDDL---YRGGLKIYTTLDPKLQKAAEKAVKNVlPEGKPGGLQAALVVVDPKTGE 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 370 LVAISGGRNYKNvVERNQATD-PHPTGSSLKPFlAYGPAIENmKWSTNHVIQDES-SYWVDGSQFKNYDTKGHGTVSIYD 447
Cdd:COG0744  339 VLAMVGGRDYGK-SQFNRATQaKRQPGSTFKPF-VYAAALEQ-GYTPATTVDDEPvTFPGGGWSPKNYDGRYRGPVTLRE 415

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 448 ALRQSFNIPALKTWQQVksqaGNDAPQKFASKLGLDYSGKIGPSEVLGgsSSEFSPTQLASAFAAIANGGTYNNAHSIQK 527
Cdd:COG0744  416 ALANSLNTPAVRLAQEV----GLDKVVDTARRLGITSPLDPNPSLALG--TSEVSPLEMASAYATFANGGVYVEPHAITK 489

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 528 VVTHEGDTI-EYEHTSHKAMKDYTSYMLAEILKGTFKaYGSAYGHGVSGVNMGAKTGTgTygqeiyekynlpdNAAKDVW 606
Cdd:COG0744  490 VTDADGKVLyEAKPKCEQVISPEVAYLMTDMLQDVVT-SGTGRAARLPGRPVAGKTGT-T-------------NDNRDAW 554

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 607 INGFSPEYTMSVWMGFNKvkqygtNSFIGH-SEQDYPQYLYEDVMSSISS-KDGEDFKKPNDVQGSSPDSLSVSGHSDNN 684
Cdd:COG0744  555 FVGYTPQLVTAVWVGNDD------NSPMGYvTGGSLPAPIWRDFMEAALEgLPVEDFPKPSGVVRIDEPSPTPSGTEPTE 628


                 ..
gi 896441666 685 TT 686
Cdd:COG0744  629 TS 630
 
Name Accession Description Interval E-value
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 52-686 0e+00

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 564.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  52 FAYYAWKAPAFSE-SKLDDPIPAKIYDKNGELVKTLdNGQRHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGA 130
Cdd:COG0744   34 VALYVADLPDPEElEDLALPQTSTIYDRDGTLIATL-GDENREWVPLDQIPPHLKDAVVAIEDRRFYEHGGVDPKGIARA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 131 IGKNLTGGFGSQGASTLTQQVVKDSFLTQQKSIGRKAQEAYLSYRLEQEYSKDEIFQVYMNKIYYSDGVTGIKAAAKYYF 210
Cdd:COG0744  113 LVANLTAGGVVQGGSTITQQLVKNLFLSNERTLSRKLKEALLALKLERKYSKDEILELYLNTVYFGRGAYGIEAAAQYYF 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 211 NKDMKDLNLAEEAYLAGLPQVPNLYNIYNNPKEANNRKDTVLYLMHKHNRINDKQYADAKKIDLKANlvertkkerQVTG 290
Cdd:COG0744  193 GKSASDLTLAEAALLAGLVKAPSYYDPYRNPEAAKERRNLVLDRMVEQGYITQAEADAAKAEPLTLV---------PPPN 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 291 NEKNPEYDSYVNFVQSELMNNkyFKDKNLgsvLQSGIKIYTNMDKDVQQTLQDRINNG-SFYKNEDQQVGATILDSKTGG 369
Cdd:COG0744  264 GAAAGKYPYFVDYVRRELEEL--LGEDDL---YRGGLKIYTTLDPKLQKAAEKAVKNVlPEGKPGGLQAALVVVDPKTGE 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 370 LVAISGGRNYKNvVERNQATD-PHPTGSSLKPFlAYGPAIENmKWSTNHVIQDES-SYWVDGSQFKNYDTKGHGTVSIYD 447
Cdd:COG0744  339 VLAMVGGRDYGK-SQFNRATQaKRQPGSTFKPF-VYAAALEQ-GYTPATTVDDEPvTFPGGGWSPKNYDGRYRGPVTLRE 415

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 448 ALRQSFNIPALKTWQQVksqaGNDAPQKFASKLGLDYSGKIGPSEVLGgsSSEFSPTQLASAFAAIANGGTYNNAHSIQK 527
Cdd:COG0744  416 ALANSLNTPAVRLAQEV----GLDKVVDTARRLGITSPLDPNPSLALG--TSEVSPLEMASAYATFANGGVYVEPHAITK 489

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 528 VVTHEGDTI-EYEHTSHKAMKDYTSYMLAEILKGTFKaYGSAYGHGVSGVNMGAKTGTgTygqeiyekynlpdNAAKDVW 606
Cdd:COG0744  490 VTDADGKVLyEAKPKCEQVISPEVAYLMTDMLQDVVT-SGTGRAARLPGRPVAGKTGT-T-------------NDNRDAW 554

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 607 INGFSPEYTMSVWMGFNKvkqygtNSFIGH-SEQDYPQYLYEDVMSSISS-KDGEDFKKPNDVQGSSPDSLSVSGHSDNN 684
Cdd:COG0744  555 FVGYTPQLVTAVWVGNDD------NSPMGYvTGGSLPAPIWRDFMEAALEgLPVEDFPKPSGVVRIDEPSPTPSGTEPTE 628


                 ..
gi 896441666 685 TT 686
Cdd:COG0744  629 TS 630
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 91-656 5.70e-151

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 450.17  E-value: 5.70e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666   91 RHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGAIGKNLTGGFGSQGASTLTQQVVKDSFLTQQKSIGRKAQEA 170
Cdd:TIGR02074   1 RREYVPIDDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVANITSGRVLEGGSTITQQLAKNLYLTNERTITRKIQEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  171 YLSYRLEQEYSKDEIFQVYMNKIYYSDGVTGIKAAAKYYFNKDMKDLNLAEEAYLAGLPQVPNLYNIYNNPKEANNRKDT 250
Cdd:TIGR02074  81 LLALKLEQKLSKDEILELYLNRIYFGNGAYGIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNPFKNPERAKDRRNL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  251 VLYLMHKHNRINDKQYADAKKIDLKANLveRTKKERQVTgneknpeYDSYVNFVQSELmnnkyfkDKNLGSVL-QSGIKI 329
Cdd:TIGR02074 161 VLSNMVENGYITAEEAEEAINEPIQLYL--QTKKSEQYK-------APYFVDYVIQEL-------EEEYGEELyTGGLKI 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  330 YTNMDKDVQQTLQDRINNGSFYK----NEDQQVGATILDSKTGGLVAISGGRNYKnvvER--NQAT----DPhptGSSLK 399
Cdd:TIGR02074 225 YTTLDLDAQKAAEKVLNTGLRVAgrrdGDDLQAALVAIDPDTGAVRALVGGRDYG---KSqfNRATqakrQP---GSTFK 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  400 PFLaYGPAIENmKWSTNHVIQDESSYWVDGSQF--KNYDTKGHGTVSIYDALRQSFNIPALKTWQQVksqaGNDAPQKFA 477
Cdd:TIGR02074 299 PFV-YAAALEK-GLTPATIVNDEPITYNGNGPWspKNYGGGYRGNVTLRQALAQSRNIPAVRLLQEV----GLDKVVALA 372

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  478 SKLGLDYSGKIGPSEVLGgsSSEFSPTQLASAFAAIANGGTYNNAHSIQKVVTHEGDTIeYEHTSH--KAMKDYTSYMLA 555
Cdd:TIGR02074 373 KRFGITSPLDPVLSLALG--TVEVSPLEMASAYAVFANGGKYVEPHGIRKIVDRDGKVI-YENKPKttQVISPATAYIMT 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  556 EILKGTFkAYGSAYGHGVSGVNMGAKTGTgtygqeiyekynlpDNAAKDVWINGFSPEYTMSVWMGFNKVKQYGtnsfIG 635
Cdd:TIGR02074 450 DMLKGVV-ESGTGRSARLPGRPVAGKTGT--------------TQNWRDAWFVGYTPYYVTAVWVGYDDKKTLG----KS 510

                         570       580
                  ....*....|....*....|.
gi 896441666  636 HSEQDYPQYLYEDVMSSISSK 656
Cdd:TIGR02074 511 GTGGGLAAPIWRDFMAEALKN 531
Transgly pfam00912
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ...
 79-256 1.69e-81

Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.


Pssm-ID: 459993 [Multi-domain]  Cd Length: 177  Bit Score: 257.07  E-value: 1.69e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666   79 NGELVKTLDnGQRHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGAIGKNLTGGFGSQGASTLTQQVVKDSFLT 158
Cdd:pfam00912   1 DGTLLAELG-EENREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLSNLRSGRIVQGGSTITQQLAKNLFLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  159 QQKSIGRKAQEAYLSYRLEQEYSKDEIFQVYMNKIYYSDGVTGIKAAAKYYFNKDMKDLNLAEEAYLAGLPQVPNLYNIY 238
Cdd:pfam00912  80 PERTLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALLAGLPQAPSRYNPL 159

                         170
                  ....*....|....*...
gi 896441666  239 NNPKEANNRKDTVLYLMH 256
Cdd:pfam00912 160 RNPERAKRRRNLVLDRMV 177
PRK14850 PRK14850
penicillin-binding protein 1b; Provisional
 62-645 3.00e-50

penicillin-binding protein 1b; Provisional


Pssm-ID: 237835 [Multi-domain]  Cd Length: 764  Bit Score: 188.52  E-value: 3.00e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  62 FSESKLDDPIPAKIYDKNGelvktldngQRHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGAIGKNLTGGFGS 141
Cdd:PRK14850 136 FSFLRLDPKLIAMLYSPEG---------KKRLFIPRNQYPEMLIKTLLAIEDKYFYEHDGIHLSSIGRAFLVNLMSGHTI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 142 QGASTLTQQVVKDSFLTQQKSIGRKAQEAYLSYRLEQEYSKDEIFQVYMNKIYY----SDGVTGIKAAAKYYFNKDMKDL 217
Cdd:PRK14850 207 QGGSTLTQQLVKNLFLTNTRSLWRKINEIYMALILDRFYSKDRILELYLNEVYLgqdgNEQIRGFPLASIYYFGRPINEL 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 218 NLAEEAYLAGLPQVPNLYNIYNNPKEANNRKDTVLYLMHKHNRINDKQYADAKKIDLKAnlvertkkerQVTGNEKNpEY 297
Cdd:PRK14850 287 NLDQYALLVGMVKGASLYNPWTNPNLTLKRRNLVLFLLYKQKVITRKLYKDLCSRPLNV----------QSKGNIIS-SH 355

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 298 DSYVNFVQSELMNNKYFKDKNLgsvlqSGIKIYTNMDKDVQQTLQDRINNG-----SFYKNEDQQVGATILDSKTGGLVA 372
Cdd:PRK14850 356 PAFIQLVCEEFHKKIHYPFKNF-----SGTKIFTTLDYISQNAAEQAVKIGipilkRKKRLKDLEVAMVIIDRFSGEVRA 430

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 373 ISGGRNyKNVVERNQATDP-HPTGSSLKPFLAYGPAIENMKWSTN--------HVIQDESSYWVDgsqfKNYDTKGHGTV 443
Cdd:PRK14850 431 LIGSSK-PEFNGYNRALKArRSIGSLSKPITYLTALSQPEKYHLNtwisdtpiSIKLDNGQYWTP----KNNNFSFSGKV 505

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 444 SIYDALRQSFNIPALktwqQVKSQAGNDAPQKFASKLGLDySGKIG--PSEVLGGSSseFSPTQLASAFAAIANGGTYNN 521
Cdd:PRK14850 506 MLIDALIHSINIPTV----HLSINLGLKKLVDSWILLGIS-SNYITplPSISLGAIN--LTPMEVAQVFQIIGSGGYKSS 578

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 522 AHSIQKVVTHEGDTI-EYEHTSHKAMKDYTSY-----MLAEILKGTFKAYGSAYghgvSGVNMGAKTGTgtygqeiyeky 595
Cdd:PRK14850 579 LSSIRSIISDDNKVLyQNFPQSKHVESSQASYltlyaMQQVVKSGTAKSLGTIF----KEFSLAGKTGT----------- 643

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|...
gi 896441666 596 nlpDNAAKDVWINGFSPEYTMSVWMGFN---KVKQYGTNSFIghseQDYPQYL 645
Cdd:PRK14850 644 ---TNNLVDSWFVGIDGKQVVITWIGRDnnhTTKLYGSSGAM----KIYKRYL 689
 
Name Accession Description Interval E-value
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 52-686 0e+00

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 564.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  52 FAYYAWKAPAFSE-SKLDDPIPAKIYDKNGELVKTLdNGQRHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGA 130
Cdd:COG0744   34 VALYVADLPDPEElEDLALPQTSTIYDRDGTLIATL-GDENREWVPLDQIPPHLKDAVVAIEDRRFYEHGGVDPKGIARA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 131 IGKNLTGGFGSQGASTLTQQVVKDSFLTQQKSIGRKAQEAYLSYRLEQEYSKDEIFQVYMNKIYYSDGVTGIKAAAKYYF 210
Cdd:COG0744  113 LVANLTAGGVVQGGSTITQQLVKNLFLSNERTLSRKLKEALLALKLERKYSKDEILELYLNTVYFGRGAYGIEAAAQYYF 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 211 NKDMKDLNLAEEAYLAGLPQVPNLYNIYNNPKEANNRKDTVLYLMHKHNRINDKQYADAKKIDLKANlvertkkerQVTG 290
Cdd:COG0744  193 GKSASDLTLAEAALLAGLVKAPSYYDPYRNPEAAKERRNLVLDRMVEQGYITQAEADAAKAEPLTLV---------PPPN 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 291 NEKNPEYDSYVNFVQSELMNNkyFKDKNLgsvLQSGIKIYTNMDKDVQQTLQDRINNG-SFYKNEDQQVGATILDSKTGG 369
Cdd:COG0744  264 GAAAGKYPYFVDYVRRELEEL--LGEDDL---YRGGLKIYTTLDPKLQKAAEKAVKNVlPEGKPGGLQAALVVVDPKTGE 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 370 LVAISGGRNYKNvVERNQATD-PHPTGSSLKPFlAYGPAIENmKWSTNHVIQDES-SYWVDGSQFKNYDTKGHGTVSIYD 447
Cdd:COG0744  339 VLAMVGGRDYGK-SQFNRATQaKRQPGSTFKPF-VYAAALEQ-GYTPATTVDDEPvTFPGGGWSPKNYDGRYRGPVTLRE 415

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 448 ALRQSFNIPALKTWQQVksqaGNDAPQKFASKLGLDYSGKIGPSEVLGgsSSEFSPTQLASAFAAIANGGTYNNAHSIQK 527
Cdd:COG0744  416 ALANSLNTPAVRLAQEV----GLDKVVDTARRLGITSPLDPNPSLALG--TSEVSPLEMASAYATFANGGVYVEPHAITK 489

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 528 VVTHEGDTI-EYEHTSHKAMKDYTSYMLAEILKGTFKaYGSAYGHGVSGVNMGAKTGTgTygqeiyekynlpdNAAKDVW 606
Cdd:COG0744  490 VTDADGKVLyEAKPKCEQVISPEVAYLMTDMLQDVVT-SGTGRAARLPGRPVAGKTGT-T-------------NDNRDAW 554

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 607 INGFSPEYTMSVWMGFNKvkqygtNSFIGH-SEQDYPQYLYEDVMSSISS-KDGEDFKKPNDVQGSSPDSLSVSGHSDNN 684
Cdd:COG0744  555 FVGYTPQLVTAVWVGNDD------NSPMGYvTGGSLPAPIWRDFMEAALEgLPVEDFPKPSGVVRIDEPSPTPSGTEPTE 628


                 ..
gi 896441666 685 TT 686
Cdd:COG0744  629 TS 630
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 91-656 5.70e-151

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 450.17  E-value: 5.70e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666   91 RHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGAIGKNLTGGFGSQGASTLTQQVVKDSFLTQQKSIGRKAQEA 170
Cdd:TIGR02074   1 RREYVPIDDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVANITSGRVLEGGSTITQQLAKNLYLTNERTITRKIQEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  171 YLSYRLEQEYSKDEIFQVYMNKIYYSDGVTGIKAAAKYYFNKDMKDLNLAEEAYLAGLPQVPNLYNIYNNPKEANNRKDT 250
Cdd:TIGR02074  81 LLALKLEQKLSKDEILELYLNRIYFGNGAYGIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNPFKNPERAKDRRNL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  251 VLYLMHKHNRINDKQYADAKKIDLKANLveRTKKERQVTgneknpeYDSYVNFVQSELmnnkyfkDKNLGSVL-QSGIKI 329
Cdd:TIGR02074 161 VLSNMVENGYITAEEAEEAINEPIQLYL--QTKKSEQYK-------APYFVDYVIQEL-------EEEYGEELyTGGLKI 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  330 YTNMDKDVQQTLQDRINNGSFYK----NEDQQVGATILDSKTGGLVAISGGRNYKnvvER--NQAT----DPhptGSSLK 399
Cdd:TIGR02074 225 YTTLDLDAQKAAEKVLNTGLRVAgrrdGDDLQAALVAIDPDTGAVRALVGGRDYG---KSqfNRATqakrQP---GSTFK 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  400 PFLaYGPAIENmKWSTNHVIQDESSYWVDGSQF--KNYDTKGHGTVSIYDALRQSFNIPALKTWQQVksqaGNDAPQKFA 477
Cdd:TIGR02074 299 PFV-YAAALEK-GLTPATIVNDEPITYNGNGPWspKNYGGGYRGNVTLRQALAQSRNIPAVRLLQEV----GLDKVVALA 372

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  478 SKLGLDYSGKIGPSEVLGgsSSEFSPTQLASAFAAIANGGTYNNAHSIQKVVTHEGDTIeYEHTSH--KAMKDYTSYMLA 555
Cdd:TIGR02074 373 KRFGITSPLDPVLSLALG--TVEVSPLEMASAYAVFANGGKYVEPHGIRKIVDRDGKVI-YENKPKttQVISPATAYIMT 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  556 EILKGTFkAYGSAYGHGVSGVNMGAKTGTgtygqeiyekynlpDNAAKDVWINGFSPEYTMSVWMGFNKVKQYGtnsfIG 635
Cdd:TIGR02074 450 DMLKGVV-ESGTGRSARLPGRPVAGKTGT--------------TQNWRDAWFVGYTPYYVTAVWVGYDDKKTLG----KS 510

                         570       580
                  ....*....|....*....|.
gi 896441666  636 HSEQDYPQYLYEDVMSSISSK 656
Cdd:TIGR02074 511 GTGGGLAAPIWRDFMAEALKN 531
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
52-622 6.54e-111

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 354.47  E-value: 6.54e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  52 FAYYAWKAPAFSEskLDD---PIPAKIYDKNGELVktldnG----QRHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDY 124
Cdd:COG5009   26 YLYLSPDLPDVET--LKDyqpPTPSRVYSADGKLI-----AefgeERRIPVPIEEIPPLLINAFLAAEDKRFYEHPGVDP 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 125 KRLFGAIGKNLTGGFGSQGASTLTQQVVKDSFLTQQKSIGRKAQEAYLSYRLEQEYSKDEIFQVYMNKIYYSDGVTGIKA 204
Cdd:COG5009   99 IGIARAAVVNLRTGRRVQGGSTITQQVAKNFLLSPERTLTRKIKEAILALRIEQELSKDEILELYLNKIYLGHRAYGVAA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 205 AAKYYFNKDMKDLNLAEEAYLAGLPQVPNLYNIYNNPKEANNRKDTVLYLMHKHNRINDKQYADAKKIDLKANLvertkk 284
Cdd:COG5009  179 AAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPIRNPERALERRNYVLGRMLELGYITQAEYEAAKAEPLTARY------ 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 285 erqvTGNEKNPEYDSYVNFVQSELMnNKYFKDKnlgsVLQSGIKIYTNMDKDVQQTLQDRINNG---------------- 348
Cdd:COG5009  253 ----HGASAEVDAPYFAEMVRRELV-ERYGEDA----LYTGGLKVYTTLDPRLQEAAEKALRDGllaydrrhgyrgpeah 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 349 ------------------------------------------------------SFYKNEDQQV---------------- 358
Cdd:COG5009  324 ldlaeedwdealaevpdvgdlrpavvlevddksarvglrdgetgtlpleglkwaRPYINDNRRGpapksasdvlkpgdvi 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 359 -------------------GATI-LDSKTGGLVAISGGRNYknvvERNQ---ATD----PhptGSSLKPFLaYGPAIENm 411
Cdd:COG5009  404 rvrpvadggwrlrqipevqGALVaLDPHTGAVLALVGGFDF----EQSKfnrATQakrqP---GSSFKPFV-YAAALDN- 474

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 412 KWSTNHVIQDES-SYWVDGSQ----FKNYDTKGHGTVSIYDALRQSFNIPALKTWQQVksqaGNDAPQKFASKLGLDysG 486
Cdd:COG5009  475 GYTPATIINDAPiVFDDGGGGgvwrPKNYSGKFYGPTTLREALEKSRNLVTVRLLQDV----GIDYVIDYAERFGIY--S 548

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 487 KIGPSE--VLGgsSSEFSPTQLASAFAAIANGGTYNNAHSIQKVVTHEGDTIeYEHTSHKAMKDY--------------- 549
Cdd:COG5009  549 KLPPNLslALG--SGEVTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVI-YRADPARACEDCdaaewdgaeprlpdp 625

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 550 --------TSYMLAEILKGTFKaYGSAYGHGVSGVNMGAKTGTgTygqeiyekynlpdNAAKDVWINGFSPEYTMSVWMG 621
Cdd:COG5009  626 aeqvidprTAYQMTSMLRGVVQ-RGTGRRARALGRDIAGKTGT-T-------------NDSKDAWFVGFTPDLVAGVWVG 690


                 .
gi 896441666 622 F 622
Cdd:COG5009  691 F 691
Transgly pfam00912
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ...
 79-256 1.69e-81

Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.


Pssm-ID: 459993 [Multi-domain]  Cd Length: 177  Bit Score: 257.07  E-value: 1.69e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666   79 NGELVKTLDnGQRHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGAIGKNLTGGFGSQGASTLTQQVVKDSFLT 158
Cdd:pfam00912   1 DGTLLAELG-EENREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLSNLRSGRIVQGGSTITQQLAKNLFLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  159 QQKSIGRKAQEAYLSYRLEQEYSKDEIFQVYMNKIYYSDGVTGIKAAAKYYFNKDMKDLNLAEEAYLAGLPQVPNLYNIY 238
Cdd:pfam00912  80 PERTLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALLAGLPQAPSRYNPL 159

                         170
                  ....*....|....*...
gi 896441666  239 NNPKEANNRKDTVLYLMH 256
Cdd:pfam00912 160 RNPERAKRRRNLVLDRMV 177
PbpC COG4953
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ...
 75-621 1.74e-62

Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443980 [Multi-domain]  Cd Length: 773  Bit Score: 223.56  E-value: 1.74e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  75 IYDKNGEL--VKTLDNGQRHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGAIGKNLTGGFGSQGASTLTQQVV 152
Cdd:COG4953   46 VLDRDGTLlrAFLAADGQWRLPVPLDEVSPRYLQALLAYEDRRFYYHPGVNPLALLRAAWQNLRSGRIVSGGSTLTMQVA 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 153 KdsfLT--QQKSIGRKAQEAYLSYRLEQEYSKDEIFQVYMNKIYYSDGVTGIKAAAKYYFNKDMKDLNLAEEAYLAGLPQ 230
Cdd:COG4953  126 R---LLepRPRTLSGKLRQILRALQLERRYSKDEILELYLNLAPYGGNIEGVEAASLAYFGKPPSRLSLAEAALLAVLPQ 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 231 VPNLYNIYNNPKEANNRKDTVLYLMHKHNRINDKQYADAK--KIDLK--------ANLVERTKKERqvtgneknpeydsy 300
Cdd:COG4953  203 APSRRRPDRNPERARAARDRVLARLAEAGVIDAEEAALALlePVPARrrplpqlaPHLARRLLRQL-------------- 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 301 vnfvqselmnnkyfkdknlgsvlQSGIKIYTNMDKDVQQTLQDRINN--GSFYKNEDQQVGATILDSKTGGLVAISGGRN 378
Cdd:COG4953  269 -----------------------PGGTRIRTTLDAGLQRRLERLVRRyvRRLKQNGIHNAAVLVVDNRTGEVLAYVGSAD 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 379 YKNvVERNQATD----PHPTGSSLKPFLaYGPAIENMKWSTNHVIQD-ESSYwvDGSQFKNYDTKGHGTVSIYDALRQSF 453
Cdd:COG4953  326 FFD-ASRQGQVDmvraLRSPGSTLKPFL-YGLALDQGLIHPETLLADvPTSF--GGYRPENFDGTFQGPVSAREALARSL 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 454 NIPALKTWQQVKsqagndaPQKFASKL------GLDYSGK-IGPSEVLGGssSEFSPTQLASAFAAIANGGTYnnahsiQ 526
Cdd:COG4953  402 NIPAVRLLEALG-------PARFYARLrraglrLLLPPAEhYGLSLILGG--AEVTLEELVGLYAALARGGEA------R 466

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 527 KVVTHEGDTIEYEHT--SHKAmkdytSYMLAEILKGTfKAYGSAYGHGV--SGVNMGAKTGTgTYGqeiYekynlpdnaa 602
Cdd:COG4953  467 PLRLLAGEPASPGRRllSPGA-----AWLVRDILSDV-PRPDGAFGWRAldSPPPIAWKTGT-SYG---F---------- 526

                        570
                 ....*....|....*....
gi 896441666 603 KDVWINGFSPEYTMSVWMG 621
Cdd:COG4953  527 RDAWAVGFTGRYTVGVWVG 545
PRK14850 PRK14850
penicillin-binding protein 1b; Provisional
 62-645 3.00e-50

penicillin-binding protein 1b; Provisional


Pssm-ID: 237835 [Multi-domain]  Cd Length: 764  Bit Score: 188.52  E-value: 3.00e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  62 FSESKLDDPIPAKIYDKNGelvktldngQRHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGAIGKNLTGGFGS 141
Cdd:PRK14850 136 FSFLRLDPKLIAMLYSPEG---------KKRLFIPRNQYPEMLIKTLLAIEDKYFYEHDGIHLSSIGRAFLVNLMSGHTI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 142 QGASTLTQQVVKDSFLTQQKSIGRKAQEAYLSYRLEQEYSKDEIFQVYMNKIYY----SDGVTGIKAAAKYYFNKDMKDL 217
Cdd:PRK14850 207 QGGSTLTQQLVKNLFLTNTRSLWRKINEIYMALILDRFYSKDRILELYLNEVYLgqdgNEQIRGFPLASIYYFGRPINEL 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 218 NLAEEAYLAGLPQVPNLYNIYNNPKEANNRKDTVLYLMHKHNRINDKQYADAKKIDLKAnlvertkkerQVTGNEKNpEY 297
Cdd:PRK14850 287 NLDQYALLVGMVKGASLYNPWTNPNLTLKRRNLVLFLLYKQKVITRKLYKDLCSRPLNV----------QSKGNIIS-SH 355

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 298 DSYVNFVQSELMNNKYFKDKNLgsvlqSGIKIYTNMDKDVQQTLQDRINNG-----SFYKNEDQQVGATILDSKTGGLVA 372
Cdd:PRK14850 356 PAFIQLVCEEFHKKIHYPFKNF-----SGTKIFTTLDYISQNAAEQAVKIGipilkRKKRLKDLEVAMVIIDRFSGEVRA 430

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 373 ISGGRNyKNVVERNQATDP-HPTGSSLKPFLAYGPAIENMKWSTN--------HVIQDESSYWVDgsqfKNYDTKGHGTV 443
Cdd:PRK14850 431 LIGSSK-PEFNGYNRALKArRSIGSLSKPITYLTALSQPEKYHLNtwisdtpiSIKLDNGQYWTP----KNNNFSFSGKV 505

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 444 SIYDALRQSFNIPALktwqQVKSQAGNDAPQKFASKLGLDySGKIG--PSEVLGGSSseFSPTQLASAFAAIANGGTYNN 521
Cdd:PRK14850 506 MLIDALIHSINIPTV----HLSINLGLKKLVDSWILLGIS-SNYITplPSISLGAIN--LTPMEVAQVFQIIGSGGYKSS 578

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 522 AHSIQKVVTHEGDTI-EYEHTSHKAMKDYTSY-----MLAEILKGTFKAYGSAYghgvSGVNMGAKTGTgtygqeiyeky 595
Cdd:PRK14850 579 LSSIRSIISDDNKVLyQNFPQSKHVESSQASYltlyaMQQVVKSGTAKSLGTIF----KEFSLAGKTGT----------- 643

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|...
gi 896441666 596 nlpDNAAKDVWINGFSPEYTMSVWMGFN---KVKQYGTNSFIghseQDYPQYL 645
Cdd:PRK14850 644 ---TNNLVDSWFVGIDGKQVVITWIGRDnnhTTKLYGSSGAM----KIYKRYL 689
mrcB PRK09506
bifunctional glycosyl transferase/transpeptidase; Reviewed
 88-631 5.48e-48

bifunctional glycosyl transferase/transpeptidase; Reviewed


Pssm-ID: 236544 [Multi-domain]  Cd Length: 830  Bit Score: 182.28  E-value: 5.48e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  88 NGQRHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGAIGKNLTGGFGSQGASTLTQQVVKDSFLTQQKSIGRKA 167
Cdd:PRK09506 207 NGEQRLFVPRSGFPDLLVDTLLATEDRHFYEHDGISLYSIGRAVLANLTAGRTVQGGSTLTQQLVKNLFLSNERSLWRKA 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 168 QEAYLSYRLEQEYSKDEIFQVYMNKIYY----SDGVTGIKAAAKYYFNKDMKDLNLAEEAYLAGLPQVPNLYNIYNNPKE 243
Cdd:PRK09506 287 NEAYMALIMDARYSKDRILELYLNEVYLgqsgDDQIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASLYNPWRNPKL 366

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 244 ANNRKDTVLYLMHKHNRINDKQYA--DAKKIDLkanlvertkkerQVTGNEKNPEyDSYVNFVQSELMNNKYFKDKNLgs 321
Cdd:PRK09506 367 ALERRNLVLRLLQQQQIIDQELYDmlSARPLGV------------QPKGGVISPQ-PAFMQMVRQELQAKLGDKVKDL-- 431

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 322 vlqSGIKIYTNMDKDVQQTLQDRINNG-----SFYKNEDQQVGATILDSKTGGLVAISGGRNyKNVVERNQATDP-HPTG 395
Cdd:PRK09506 432 ---SGVKIFTTLDPVSQDAAEKAVEEGipalkKQRKLSDLETAMVVVDRFSGEVRAMVGGSE-PQFAGYNRAMQArRSIG 507

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 396 SSLKPFLAYGPAIENMKWSTNHVIQDE--------SSYWvdgsQFKNYDTKGHGTVSIYDALRQSFNIPALKTWQQVksq 467
Cdd:PRK09506 508 SLAKPATYLTALSQPDKYRLNTWIADApislrqpnGQVW----SPQNDDRRFSGRVMLVDALTRSMNVPTVNLGMAL--- 580

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 468 aGNDAPQKFASKLGLDYS-GKIGPSEVLGGSSseFSPTQLASAFAAIANGGTYNNAHSIQKVVTHEGdTIEYEH--TSHK 544
Cdd:PRK09506 581 -GLPAVTDTWIKLGVPKDqLNPVPAMLLGALN--LTPIEVAQAFQTIASGGNRAPLSALRSVIAEDG-KVLYQSfpQAER 656

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 545 AMKDYTSY-----MLAEILKGTFKAYGSAYGhgvsGVNMGAKTGTgtygqeiyekynlpDNAAKDVWINGFSPEYTMSVW 619
Cdd:PRK09506 657 AVPAQAAYltlytMQQVVQRGTGRQLGAKYP----NLHLAGKTGT--------------TNDLVDSWFAGIDGKEVTITW 718

                        570
                 ....*....|....*
gi 896441666 620 MGFNK---VKQYGTN 631
Cdd:PRK09506 719 VGRDNnqpTKLYGAS 733
mrcA PRK11636
penicillin-binding protein 1a; Provisional
 71-347 6.93e-45

penicillin-binding protein 1a; Provisional


Pssm-ID: 183248 [Multi-domain]  Cd Length: 850  Bit Score: 173.01  E-value: 6.93e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  71 IPAKIYDKNGELVKTLDNgQRHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGAIGKNLTGGFGSQGASTLTQQ 150
Cdd:PRK11636  46 TPMQVYSADGELIAQYGE-KRRIPLTLDQIPPEMVKAFIATEDSRFYEHHGVDPVGIFRAASVALFSGHASQGASTITQQ 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 151 VVKDSFLTQQKSIGRKAQEAYLSYRLEQEYSKDEIFQVYMNKIYYSDGVTGIKAAAKYYFNKDMKDLNLAEEAYLAGLPQ 230
Cdd:PRK11636 125 LARNFFLSPERTLMRKIKEAFLAIRIEQLLTKDEILELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLTLSEMAVIAGLPK 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 231 VPNLYNIYNNPKEANNRKDTVLYLMHKHNRINDKQYADAKKIDLKANLvertkkerqvtgneKNPEYD---SYVNFVQSE 307
Cdd:PRK11636 205 APSTFNPLYSMDRAVARRNVVLSRMLDEGYITQAQYDQARSEPIVANY--------------HAPEIAfsaPYLSEMVRQ 270

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 896441666 308 LMNNKYFKDknlgsVLQSGIKIYTNMDKDVQQTLQDRINN 347
Cdd:PRK11636 271 EMYNRYGEN-----AYEDGYRVYTTITRKVQQAAQQAVRN 305
PRK13481 PRK13481
glycosyltransferase; Provisional
 90-269 7.99e-32

glycosyltransferase; Provisional


Pssm-ID: 184078 [Multi-domain]  Cd Length: 232  Bit Score: 123.76  E-value: 7.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  90 QRHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGAIGKNLTGGfGSQGASTLTQQVVKDSFLTQQKSIGRKAQE 169
Cdd:PRK13481  43 NKSSFVSADNMPEYVKGAFISMEDERFYKHHGFDLKGTTRALFSTISDR-DVQGGSTITQQVVKNYFYDNERSFTRKVKE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 170 AYLSYRLEQEYSKDEIFQVYMNKIYYSDGVTGIKAAAKYYF-------NKDMKDLNLAEEAYLAGLPQVPNLYNIYNNPK 242
Cdd:PRK13481 122 LFVAHRVEKQYSKNEILSFYLNNIYFGDNQYTLEGAANHYFgttvnknSTTMSHITVLQSAILASKVNAPSVYNINDMSE 201

                        170       180
                 ....*....|....*....|....*..
gi 896441666 243 EANNRKDTVLYLMHKHNRINDKQYADA 269
Cdd:PRK13481 202 NFTQRVSTNLEKMKQQNYINETQYQQA 228
mono_pep_trsgly TIGR02070
monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the ...
 91-233 3.00e-30

monofunctional biosynthetic peptidoglycan transglycosylase; This family is one of the transglycosylases involved in the late stages of peptidoglycan biosynthesis. Members tend to be small, about 240 amino acids in length, and consist almost entirely of a domain described by pfam00912 for transglycosylases. Species with this protein will have several other transglycosylases as well. All species with this protein are Proteobacteria that produce murein (peptidoglycan). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273951 [Multi-domain]  Cd Length: 224  Bit Score: 119.10  E-value: 3.00e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666   91 RHEHVNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGAIGKNLTGGFGSQGASTLTQQVVKDSFLTQQKSIGRKAQEA 170
Cdd:TIGR02070  54 QHRWRPYDQISPNLKRAVIASEDAKFVEHHGFDWEAIQDALEKNEKSGKVVRGGSTISQQLAKNLFLWSGRSYLRKGLEA 133

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 896441666  171 YLSYRLEQEYSKDEIFQVYMNKIYYSDGVTGIKAAAKYYFNKDMKDLNLAEEAYLAGLpqVPN 233
Cdd:TIGR02070 134 WATWMLETWWSKQRILEVYLNSVEWGNGVFGAEAAARYYFKRSASNLTRGQAARLAAV--LPN 194
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 324-618 2.24e-28

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 120.70  E-value: 2.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 324 QSGIKIYTNMDKDVQQTLQDRINNGsFYKNEDQQVGATILDSKTGGLVAISG--------GRNYKNVVERNQA-TDPHPT 394
Cdd:COG0768  216 VPGKDLVLTIDSDLQKIAEEALKKA-VEEYKAKSGAVVVMDPKTGEILAMASypsfdpnlFVGGPDEPLRNRAvQGTYEP 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 395 GSSLKPFLAYGpAIENMKWSTNHVIQDESSYWVDGSQFKNYDTKGHGTVSIYDALRQSFNIPALKTWQQVksqaGNDAPQ 474
Cdd:COG0768  295 GSTFKPFTAAA-ALEEGVITPDTTFDCPGYYRVGGRTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRL----GIDKLY 369

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 475 KFASKLGLDYSGKIG-PSEVLG--GSSSEFSPT----------------QLASAFAAIANGGTYNNAHSIQKVVTHEGDT 535
Cdd:COG0768  370 DYLKKFGLGQKTGIDlPGEASGllPSPKRWYPGetatmsigqglsvtplQLAQAYAAIANGGVLVKPHLVKEIVDPDGEV 449

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 536 IEYE-HTSHKAMKDYTSYMLAEILKGTF-KAYGSAYGHGVSGVNMGAKTGTGtygqeiyEKYNLPDNAAKD----VWING 609
Cdd:COG0768  450 VKEEpEVLRRVISPETAETVREGMEGVVnEPGGTARRAAIPGYRVAGKTGTA-------QVVDIGNGGYYKgrhiASFVG 522

                        330
                 ....*....|...
gi 896441666 610 F----SPEYTMSV 618
Cdd:COG0768  523 FapadNPRYAVAV 535
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 359-618 1.73e-26

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 110.20  E-value: 1.73e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  359 GATILDSKTGGLVAISGGRNY----KNVVERNQA-TDPHPTGSSLKPFLAyGPAIENMKWSTNHVIQDESSYWVDGSQFK 433
Cdd:pfam00905   2 SAVVLDPKTGEVLAMVGKPSYdpngFIGPLRNRAvTSRYEPGSTFKPFTA-LAALDNGVLKPDETIFDWPGKQQGGKSIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  434 NYDTKGHGTVSIYDALRQSFNIPALKTWQQVKSQAGNDAPQKF--ASKLGLDYSGKIG---PSEVLGGSSSEF------S 502
Cdd:pfam00905  81 DWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFgyGNKTGIGLPGENAgylTPYWLEGATASFgigltiT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  503 PTQLASAFAAIANGGTYNNAHSIQKVVthegDTIEYEHTSHKAMKDYTSYMLAEILKGTFKAYGSAYGHGVSGVNMGAKT 582
Cdd:pfam00905 161 PLQQAQAYAAIANGGKLVPPHLVKSIE----DKVDPKVLNKLPISKSTAEKVKDMLRLVVNDGTGTGTAAVPGYKVAGKT 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 896441666  583 GTgtyGQEIYEKYNLPDNAAKDVWINGFS----PEYTMSV 618
Cdd:pfam00905 237 GT---AQVAGPKGGGYYDGAQIGWFVGYApadnPKYAFAV 273
PRK11240 PRK11240
penicillin-binding protein 1C; Provisional
 95-621 5.55e-23

penicillin-binding protein 1C; Provisional


Pssm-ID: 183049 [Multi-domain]  Cd Length: 772  Bit Score: 104.78  E-value: 5.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  95 VNIKDVPKDMKNAVLATEDNRFYQHGALDYKRLFGAIGKNLTGGFGSQGASTLTQQVVK------DSFLTQQKSIGRKAQ 168
Cdd:PRK11240  65 VTIEDVSPRYLEALINYEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVARlldphpRTFGGKIRQLWRALQ 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 169 eaylsyrLEQEYSKDEIFQVYMNKIYYSDGVTGIKAAAKYYFNKDMKDLNLAEEAYLAGLPQVPNLYNIYNNPKEANNRK 248
Cdd:PRK11240 145 -------LEWHLSKREILTLYLNRAPFGGTLQGIGAASWAYLGKSPANLSYAEAALLAVLPQAPSRLRPDRWPERAEAAR 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 249 DTVLYLMHKHNRINDKQYADAKKIDLKAnlvertkKERQVtgneknPEYDSYVnfvqSELMNNKYFKDknlgsvlqsgiK 328
Cdd:PRK11240 218 NKVLERMAEQGVWSAEQVKESREEPVWL-------APRQM------PQLAPLF----ARMMLGKSKSD-----------K 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 329 IYTNMDKDVQQTLQDRINNGSFYKNEDQQVGATILDSKTG------GLVAISGGRNYKNVVERNQATDPhptGSSLKPFL 402
Cdd:PRK11240 270 IVTTLDAGLQRRLEDLALNWKGRLPPRSSLAMIVVDHTDMavrgwvGSVDLNDDSRFGHVDMVNAIRSP---GSVLKPFV 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 403 aYGPAIENMKWSTNHVIQD---ESSYWVDGsqfkNYDTKGHGTVSIYDALRQSFNIPALktwqQVKSQAGndaPQKFASK 479
Cdd:PRK11240 347 -YGLALDDGLIHPASLLQDvprRTGDYRPG----NFDSGFHGPVSMSEALVRSLNLPAV----QVLEAYG---PKRFAAK 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666 480 L---GLDYSGKIGP----SEVLGGSSSEFSptQLASAFAAIANGGtynnahSIQKVVTHEGDTIeyehTSHKAMKDYTSY 552
Cdd:PRK11240 415 LrnvGLPLYLPAGAepnlSLILGGAGARLE--DMVAAYSAFARHG------KAAKLRLQPDDPL----LERPLMSPGAAW 482

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896441666 553 MLAEILKGtfKAYGSAYGHGVSGVNMGAKTGTgTYGqeiYekynlpdnaaKDVWINGFSPEYTMSVWMG 621
Cdd:PRK11240 483 IIRRIMAD--EAQPLPDAALPRVVPLAWKTGT-SYG---Y----------RDAWAIGVNARYVIGIWTG 535
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 324-618 2.96e-13

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 72.94  E-value: 2.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  324 QSGIKIYTNMDKDVQQTLQDRInngsfyknEDQQVGATILDSKTGGLVA---------------ISGgRNYKNVVE---- 384
Cdd:TIGR03423 223 VPGKDLVLTIDARLQQAAEKAL--------GGRRGAVVVMDPRTGEILAmvstpsfdpnlfvdgISS-KDYKALLNdpdr 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  385 --RNQATDPH-PTGSSLKPFLAyGPAIENMKWSTNHVIQDESSYWVDGSQFKNYDTKGHGTVSIYDALRQSFNipalkTW 461
Cdd:TIGR03423 294 plLNRAIQGVyPPGSTFKPVVA-LAALEEGVITPETRIYCPGYFQLGGRRFRCWKRGGHGRVDLRKAIEESCD-----VY 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  462 -QQVKSQAGNDAPQKFASKLGL-DYSGKIGPSEVLG------------------GSSSEFS---------PTQLASAFAA 512
Cdd:TIGR03423 368 fYQLALRLGIDKIAEYAKRFGFgQKTGIDLPGEKSGlvpsrewkrkrfgqpwypGDTLNVSigqgyvlvtPLQLAVATAA 447

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896441666  513 IANGGTYNNAHSIQKVVTHEGDTIEYEHTSHKAMKDYTSYMLAEILKGTF----KAYGSAYGHGV-SGVNMGAKTGTG-T 586
Cdd:TIGR03423 448 LANGGKLYKPHLVKSIEDPDGGVVRRTEPEVLRPLPISPENLDVVREGMRdvvnGPGGTARRARLgLPYKMAGKTGTAqV 527

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 896441666  587 YGQEIYEKYN-------LPDNAakdvWINGF----SPEYTMSV 618
Cdd:TIGR03423 528 VSLKQGEKYDaeqiperLRDHA----LFVAFapydNPKIAVAV 566
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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