|
Name |
Accession |
Description |
Interval |
E-value |
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
9-352 |
0e+00 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 651.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 9 MDCFFAAVEMRDDPSLRDIPLAIGGSADRRGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAYKEASLHIRE 88
Cdd:PRK02406 1 MDCFYAAVEMRDNPELRGKPVAVGGSPGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 89 IFARYTSLIEPLSLDEAYLDVTDSPQCNGSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEMNKPNGQYVITPAQ 168
Cdd:PRK02406 81 IFRRYTDLIEPLSLDEAYLDVTDNKLCIGSATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 169 VPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFGKFGRVLWERCQGIDRREISPERLRKSVGVERT 248
Cdd:PRK02406 161 VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRRLYERARGIDERPVKPDRERKSVGVERT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 249 LAEDIHDWEDCEtLIIDKLYPELEMRLRKVKPDLHIARQGVKLKFQDFQQTTQEHVFPVLNRQDLLEVARQAWRERREGR 328
Cdd:PRK02406 241 FAEDLYDLEACL-AELPRLAEKLERRLERAKPDKRIKTVGVKLKFADFQQTTKEHTADPLDKADLIELLAQALLRRLGGR 319
|
330 340
....*....|....*....|....
gi 896198631 329 GVRLVGLHVTLLDPQLERQLALSW 352
Cdd:PRK02406 320 GVRLLGVGVTLLEPQLERQLLLDL 343
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
5-340 |
2.35e-169 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 474.70 E-value: 2.35e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 5 IHVDMDCFFAAVEMRDDPSLRDIPLAIGGSADRrGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAYKEASL 84
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSDR-GVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 85 HIREIFARYTSLIEPLSLDEAYLDVTDSPQCNGSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEMNKPNGQYVI 164
Cdd:cd03586 80 QIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 165 TPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFGKFGRVLWERCQGIDRREISPERLRKSVG 244
Cdd:cd03586 160 PPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 245 VERTLAEDIHDWEDCETlIIDKLYPELEMRLRKVKpdLHIARQGVKLKFQDFQQTTQE--HVFPVLNRQDLLEVARQAWR 322
Cdd:cd03586 240 VERTFSEDLTDPEELLE-ELLELAEELAERLRKRG--LKGRTVTVKLKYADFSTRTRSrtLPEPTDDAEDIYELALELLE 316
|
330
....*....|....*...
gi 896198631 323 ERREGRGVRLVGLHVTLL 340
Cdd:cd03586 317 ELLDGRPIRLLGVRLSGL 334
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
2-338 |
3.78e-148 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 421.09 E-value: 3.78e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 2 RKIIHVDMDCFFAAVEMRDDPSLRDIPLAIGGSAdRRGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAYKE 81
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVGGDN-NRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 82 ASLHIREIFARYTSLIEPLSLDEAYLDVTDSPQCNGSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEMNKPNGQ 161
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 162 YVITPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFGKFGRVLWERCQGIDRREISPERLRK 241
Cdd:COG0389 160 TVIPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVEPRRPRK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 242 SVGVERTLAEDIHDWEDCETlIIDKLYPELEMRLRKVkpDLHIARQGVKLKFQDFQQTTQEHVF--PVLNRQDLLEVARQ 319
Cdd:COG0389 240 SIGVERTFGEDLTDLEELEA-ALRRLAERLAERLRRQ--GLGARTVTVKLRTSDFRTTTRSRTLpePTDDTAELLRAARE 316
|
330 340
....*....|....*....|
gi 896198631 320 AWRERREGRGV-RLVGLHVT 338
Cdd:COG0389 317 LLERIYRPGRPvRLLGVRLS 336
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
1-350 |
2.69e-93 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 281.99 E-value: 2.69e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 1 MRKIIHVDMDCFFAAVEMRDDPSLRDIPLAIGGSADRrGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAYK 80
Cdd:PRK14133 2 DRVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGISER-GVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 81 EASLHIREIFARYTSLIEPLSLDEAYLDVTDspqCNGSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEMNKPNG 160
Cdd:PRK14133 81 EVSKNIFKILYEVTPIVEPVSIDEAYLDITN---IKEEPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 161 QYVITPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFGKFGRVLWERCQGIDRREISPERLR 240
Cdd:PRK14133 158 IKIITEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGIDYREVEVSRER 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 241 KSVGVERTLAEDIHDWEDCETLIIDkLYPELEMRLRkvKPDLHIARQGVKLKFQDFQQTTQEHVFP--VLNRQDLLEVAR 318
Cdd:PRK14133 238 KSIGKETTLKKDTKDKEELKKYLKD-FSNIISEELK--KRNLYGKTVTVKIKTSDFQTHTKSKTLNdyIRDKEEIYNVAC 314
|
330 340 350
....*....|....*....|....*....|..
gi 896198631 319 QAWRERREGRGVRLVGLHVTLLDPQLERQLAL 350
Cdd:PRK14133 315 EILEHINIKEPIRLIGLSVSNLSENKIEQLSF 346
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
4-300 |
3.52e-91 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 279.12 E-value: 3.52e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 4 IIHVDMDCFFAAVEMRDDPSLRDIPLAIGGSadRRGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAYKEAS 83
Cdd:PRK02794 38 IAHIDCDAFYASVEKRDNPELRDKPVIIGGG--KRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 84 LHIREIFARYTSLIEPLSLDEAYLDVTDSPQCNGS--ATLIAQEIRQaIAAELNLTASAGIAPIKFLAKIASEMNKPNGQ 161
Cdd:PRK02794 116 REVRAMMQALTPLVEPLSIDEAFLDLSGTERLHGAppAVVLARFARR-VEREIGITVSVGLSYNKFLAKIASDLDKPRGF 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 162 YVITPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFGKFGRVLWERCQGIDRREISPERLRK 241
Cdd:PRK02794 195 SVIGRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGIDDRKVSPDREAK 274
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 896198631 242 SVGVERTLAEDIHDWEDCEtliiDKLYPELEMRLRKVKPDlHIARQGV--KLKFQDFQQTT 300
Cdd:PRK02794 275 SVSAETTFETDLSDFEDLE----PILWRLSEKVSRRLKAA-GLAGRTVtlKLKTADFRLRT 330
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
2-321 |
1.63e-85 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 264.20 E-value: 1.63e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 2 RKIIHVDMDCFFAAVEMRDDPSLRDIPLAIGGSA-DRRGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAYK 80
Cdd:PRK01810 5 RVIFHVDMNSFFASVEIAYDPSLQGKPLAVAGNEkERKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRYR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 81 EASLHIREIFARYTSLIEPLSLDEAYLDVTDSPQcNGSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEMNKPNG 160
Cdd:PRK01810 85 EASRQMFQILSEFTPLVQPVSIDEGYLDITDCYA-LGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 161 QYVITPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFGKFGRVLWERCQGIDRREISPERL- 239
Cdd:PRK01810 164 ITVLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGIDDRPVDPEAIy 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 240 -RKSVGVERTLAEDIHDWEDCeTLIIDKLYPELEMRLRKVkpdlHIARQGVKL--KFQDFQQTTQEHVF--PVLNRQDLL 314
Cdd:PRK01810 244 qFKSVGNSTTLSHDMDEEKEL-LDVLRRLSKSVSKRLQKK----TVVSYNVQImiRYHDRRTITRSKTLknPIWEKRDIF 318
|
....*..
gi 896198631 315 EVARQAW 321
Cdd:PRK01810 319 QAASRLF 325
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
2-279 |
4.57e-77 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 242.22 E-value: 4.57e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 2 RKIIHVDMDCFFAAVEMRDDPSLRDIPLAIGGSADRRGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAYKE 81
Cdd:cd01701 47 RIIMHVDFDCFFVSVSIRNRPDLKGKPVAVCHGKGPNSEIASCNYEARSYGIKNGMWVGQAKKLCPQLVTLPYDFEAYEE 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 82 ASLHIREIFARYTSLIEPLSLDEAYLDVTDSPQC-NGSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEMNKPNG 160
Cdd:cd01701 127 VSLTFYEILASYTDNIEAVSCDEALIDITSLLEEtYELPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAKPDG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 161 QYVITPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYD--LAQLLKRFG-KFGRVLWERCQGIDRREISPE 237
Cdd:cd01701 207 QYHLSAEKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRSktKEKLQKVLGpKTGEKLYDYCRGIDDRPVTGE 286
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 896198631 238 RLRKSVGVERTLAEDIHDWEDCEtLIIDKLYPELEMRLRKVK 279
Cdd:cd01701 287 KERKSVSAEINYGIRFTNVDDVE-QFLQRLSEELSKRLEESN 327
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
1-318 |
3.16e-75 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 239.07 E-value: 3.16e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 1 MRKIIHVDMDCFFAAVEMRDDPSLRDIPLAIGGSADRrGVISTANYPARRYGVHSAMSTAMALKLCPHLT-LLPGRMAAY 79
Cdd:PRK03348 4 QRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGR-GVVAGASYEARVFGARSAMPMHQARRLVGNGAvVLPPRFVVY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 80 KEASLHIREIFARYTSLIEPLSLDEAYLD----VTDSPqcnGSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEM 155
Cdd:PRK03348 83 RAASRRVFDTLRELSPVVEQLSFDEAFVEpaelAGASA---EEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 156 NKPNGQYVITPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFGK-FGRVLWERCQGIDRREI 234
Cdd:PRK03348 160 AKPDGIRVVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLGAtVGPALHRLARGIDDRPV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 235 SPERLRKSVGVERTLAEDIHDWEDCETlIIDKLYPELEMRLRKvkpDLHIARQ-GVKLKFQDFQQTTQEHVFP--VLNRQ 311
Cdd:PRK03348 240 AERAEAKQISAESTFAVDLTTRAQLRE-AIERIAEHAHRRLLK---DGRGARTvTVKLRKSDFSTLTRSATLPyaTDDAA 315
|
....*..
gi 896198631 312 DLLEVAR 318
Cdd:PRK03348 316 VLAATAR 322
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
4-350 |
5.51e-74 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 234.11 E-value: 5.51e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 4 IIHVDMDCFFAAVEMRDDPSLRDIPLAIGGsadrrGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAYKEAS 83
Cdd:PRK03858 6 ILHADLDSFYASVEQRDDPALRGRPVIVGG-----GVVLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 84 LHIREIFARYTSLIEPLSLDEAYLDVTDSPQCNGSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEMNKPNGQYV 163
Cdd:PRK03858 81 KAVFEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 164 ITPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFGK-FGRVLWERCQGIDRREISPERLRKS 242
Cdd:PRK03858 161 VPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSLLGPaAGRHLHALAHNRDPRRVETGRRRRS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 243 VGVERTLAEDIHDWEDCETLIIdKLYPELEMRLRKVkpdlhiARQG----VKLKFQDFQQTTQEHVF--PVLNRQDLLEV 316
Cdd:PRK03858 241 VGAQRALGRGPNSPAEVDAVVV-ALVDRVARRMRAA------GRTGrtvvLRLRFDDFTRATRSHTLprPTASTATLLAA 313
|
330 340 350
....*....|....*....|....*....|....*..
gi 896198631 317 ARQ---AWRERREGRGVRLVGLHVTLLDPQLERQLAL 350
Cdd:PRK03858 314 ARDlvaAAAPLIAERGLTLVGFAVSNLDDDGAQQLEL 350
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
1-277 |
2.15e-66 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 214.87 E-value: 2.15e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 1 MRKIIHVDMDCFFAAVEMRDDPSLRDIPLAIGGSADRR-GVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAY 79
Cdd:PRK03103 2 ERVILLVDMQSFYASVEKAANPELKGRPVIVSGDPERRsGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 80 KEASLHIREIFARYTSLIEPLSLDEAYLDVTDSPQCNGSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEM---N 156
Cdd:PRK03103 82 IDVSLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFGSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDNfakK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 157 KPNGQYVITPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFGKFGRVLWERCQGIDRREISP 236
Cdd:PRK03103 162 NPDGLFTLDKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANGIDYSPVTP 241
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 896198631 237 ERL--RKSVGVERTLAEDIHDWEDCETLIIDkLYPELEMRLRK 277
Cdd:PRK03103 242 HSLdrQKAIGHQMTLPRDYRGFEEIKVVLLE-LCEEVCRRARA 283
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
6-277 |
2.88e-66 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 212.61 E-value: 2.88e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 6 HVDMDCFFAAVEMRDDPSLRDIPLAIGGSADRRGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAYKEASLH 85
Cdd:cd00424 2 HIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 86 IREIFARYTSLIEPLSLDEAYLDVTDSPQCNGSATLIAQEIRQAIAAELN-LTASAGIAPIKFLAKIASEMNKPNGQYVI 164
Cdd:cd00424 82 LLSELEEVAPLVEVASIDELFLDLTGSARLLGLGSEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAKPDGLTIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 165 TPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLL-KRFGKFGRVLWERCQGIDRREISPERLRKSV 243
Cdd:cd00424 162 DPEDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALLaLWGGVSGERLWYALRGIDDEPLSPPRPRKSF 241
|
250 260 270
....*....|....*....|....*....|....
gi 896198631 244 GVERTLAEDIHDWEDCETLIIDkLYPELEMRLRK 277
Cdd:cd00424 242 SHERVLPRDSRNAEDARPLLRL-LLEKLARRLRR 274
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
7-154 |
1.95e-62 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 195.87 E-value: 1.95e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 7 VDMDCFFAAVEMRDDPSLRDIPLAIGGSaDRRGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAYKEASLHI 86
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGG-NGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896198631 87 REIFARYTS-LIEPLSLDEAYLDVTDSPQCNGSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASE 154
Cdd:pfam00817 80 FEILRRFSTpKVEQASIDEAFLDLTGLEKLFGAEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
6-277 |
3.00e-54 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 182.13 E-value: 3.00e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 6 HVDMDCFFAAVEMRDDPSLRDIPLAIggsADRRGVISTaNYPARRYGVHSAMSTAMALKLCPHLtlLPGRMAAYK----- 80
Cdd:cd01702 2 HIDMDAFFAQVEQVRLGLLRNDPVAV---VQWNSIIAV-SYAARAFGVTRFMTIDEAKKKCPDL--ILAHVATYKkgede 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 81 --------------------EASLHIREIFARYTSLIEPLSLDEAYLDVtdspqcnGSAtlIAQEIRQAIAAELNLTASA 140
Cdd:cd01702 76 adyhenpsparhkvsldpyrRASRKILNILKRFGDVVEKASIDEAYLDL-------GSR--IVEEIRQQVYDELGYTCSA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 141 GIAPIKFLAKIASEMNKPNGQYVITPAQVPAFLQQLPLSKIPGV-GKVTAKRLEEVGLITCADVQQYDLAQLL---KRFG 216
Cdd:cd01702 147 GIAHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLPITSIRGLgGKLGEEIIDLLGLPTEGDVAGFRSSESDlqeHFGE 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 896198631 217 KFGRVLWERCQGIDRREISPERLRKSVGVERTLA-------EDIHDWedcetliIDKLYPELEMRLRK 277
Cdd:cd01702 227 KLGEWLYNLLRGIDHEPVKPRPLPKSMGSSKNFPgktalstEDVQHW-------LLVLASELNSRLED 287
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
4-293 |
2.90e-52 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 176.52 E-value: 2.90e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 4 IIHVDMDCFFAAVEMRDDPSLRDIPLAI---GGSADRRGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAYK 80
Cdd:PRK01216 3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVcvySGRFEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 81 EASLHIREIFARYTSLIEPLSLDEAYLDVTDSPQCNGSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEMNKPNG 160
Cdd:PRK01216 83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 161 QYVITPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFGKF-GRVLWERCQGIDRREISPeRL 239
Cdd:PRK01216 163 IKVIDDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIGEAkAKYLFSLARNEYNEPVRA-RV 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 896198631 240 RKSVGVERTLAEDIHDWEDCETLI---IDKLYPEL-----EMRLRKVKPDLHIARQGVKLKF 293
Cdd:PRK01216 242 RKSIGRYVTLPRNTRDLEEIKPYLkraIEEAYYKLdgipkAIHVVAIMEDLDIVSRGRTFTH 303
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
1-260 |
7.70e-52 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 175.21 E-value: 7.70e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 1 MRKIIHVDMDCFFAAVEMRDDPSLRDIPLAIGGSAD---RRGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMA 77
Cdd:PRK03352 4 PRWVLHVDLDQFIAAVELLRRPELAGLPVIVGGNGDptePRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 78 AYKEASLHIREIFARYTSLIEPLSLDEAYLDV-TDSPqcngsaTLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEMN 156
Cdd:PRK03352 84 AYDAASEEVMATLRDLGVPVEVWGWDEAFLGVdTDDP------EALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 157 KPNGQYVITPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFG-KFGRVLWERCQGIDRREIS 235
Cdd:PRK03352 158 KPAGVFRLTDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpTTGPWLLLLARGGGDTEVS 237
|
250 260
....*....|....*....|....*.
gi 896198631 236 PE-RLRKSVGVERTLAEDIHDWEDCE 260
Cdd:PRK03352 238 AEpWVPRSRSREVTFPQDLTDRAEVE 263
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
5-282 |
7.76e-51 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 173.43 E-value: 7.76e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 5 IHVDMDCFFAAVEMRDDPSLRDIPLAIggsaDRRGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGR-MAAYKEAS 83
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGI----QQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEdLTPFRDMS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 84 LHIREIFARYT--SLIEPLSLDEAYLDVTDSPQCNGSAtlIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEMNKPNGQ 161
Cdd:cd01703 77 KKVYRLLRSYSwnDRVERLGFDENFMDVTEMRLLVASH--IAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 162 YVITP---AQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYD------------LAQLLKRFGKFGRV----L 222
Cdd:cd01703 155 TTLLPpscADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEFSnrnrqtvgaapsLLELLLMVKEFGEGigqrI 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 896198631 223 WERCQGIDRREISPER-LRKSVGVERTLAEdihdwedCETLIIDKLYPELEMR----LRKVKPDL 282
Cdd:cd01703 235 WKLLFGRDTSPVKPASdFPQQISIEDSYKK-------CSLEEIREARNKIEELlaslLERMKQDL 292
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
5-278 |
2.10e-46 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 165.96 E-value: 2.10e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 5 IHVDMDCFFAAVEMRDDPSLRDIPLAIGGSAdrrgVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAYKEASL 84
Cdd:PTZ00205 136 IHLDMDMFYAAVEIKKHPEYAAIPLAIGTMT----MLQTANYVARGRGIRQGMPGFLALKICPNLLILPPDFDAYNEESN 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 85 HIREIFARYTSLIEPLSLDEAYLDVT---DSPQCNGSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEMNKPNGQ 161
Cdd:PTZ00205 212 TVRRIVAEYDPNYISFGLDELTLEVSayiERFEGTKTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNINKPNGQ 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 162 YVI---TPAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQ------YDLAQLLKRF---GKFGRVLW------ 223
Cdd:PTZ00205 292 HDLnlhTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNrrvelcYILHNNLFRFllgASIGIMQWpdaata 371
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 896198631 224 ---ERCQGIDRREisperlRKSVGVERTL-----AEDIHDWEDcetLIIDKLYPEL---EMRLRKV 278
Cdd:PTZ00205 372 antENCEGATGGQ------RKAISSERSFttprtKEGLQEMVD---TVFNGAYEEMrksELMCRQI 428
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
7-258 |
5.51e-42 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 149.24 E-value: 5.51e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 7 VDMDCFFAAVEMRDDPSLRDIPLAIGGSADRRgVIStANYPARRYGVhsamSTAMALKLCPHL------TLLPGRMAAYK 80
Cdd:cd01700 3 VDCNSFYASCERVFRPLLLGRPLVVLSNNDGC-VIA-RSPEAKALGI----KMGSPYFKVPDLlerhgvAVFSSNYALYG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 81 EASLHIREIFARYTSLIEPLSLDEAYLDVTDSPQCnGSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEM----N 156
Cdd:cd01700 77 DMSRRIMSILERFSPDVEVYSIDESFLDLTGSLRF-GDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLakkkN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 157 KPNGQYVIT-PAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFGKFGRVLWERCQGIDRREIS 235
Cdd:cd01700 156 PYGGVVDLTdEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLE 235
|
250 260
....*....|....*....|....
gi 896198631 236 PER-LRKSVGVERTLAEDIHDWED 258
Cdd:cd01700 236 EYPpPKKSIGSSRSFGRDVTDLDE 259
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
19-257 |
4.49e-25 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 103.62 E-value: 4.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 19 RDDPSLRDIPLAIGgSADRRGVISTANYPARRYGVHSAMSTAMALKLCPHLTLLPGRMAAYKEASLHIREIFARYTSLIE 98
Cdd:cd03468 15 RNRPADDEAPLAVV-ERKKAGRILACNAAARAAGVRPGMPLAEALALCPNLQVVEYDPEADARALQELALWLLRFTPLVA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 99 PLSLDEAYLDVTDSPQCNGSATLIAQEIRQAiAAELNLTASAGIAPIKFLAKIASEMNKPNGQYVITPAQVPAFLQQLPL 178
Cdd:cd03468 94 LDGPDGLLLDVTGCLHLFGGEDALAASLRAA-LATLGLSARAGIADTPGAAWLLARAGGGRGVLRREALAAALVLLAPLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 179 SKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFGKFGRVLWERCQGIDRREI--SPERLRKSVGVERTLAEDIHDW 256
Cdd:cd03468 173 VAALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRDPEPLlfSPPPPAFDFRLELQLEEPIARG 252
|
.
gi 896198631 257 E 257
Cdd:cd03468 253 L 253
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
240-343 |
1.40e-10 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 57.57 E-value: 1.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 240 RKSVGVERTLAEDIHDWEDCETlIIDKLYPELEMRLRKVKpdLHIARQGVKLKFQDFQQTTQEHVFPVL--NRQDLLEVA 317
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELRE-ALLELAEELAERLRRQG--LVARTVTVKIRYSDFRTITRSVTLPSPtdDTDEIYRAA 77
|
90 100
....*....|....*....|....*.
gi 896198631 318 RQAWRERREGRGVRLVGLHVTLLDPQ 343
Cdd:pfam11799 78 LRLLRRLYRGRPVRLLGVSLSNLVPE 103
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
97-225 |
6.41e-09 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 57.08 E-value: 6.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896198631 97 IEPLSLDEAYLDVTDSPQCNgSATLIAQEIRQAIAAELNLTASAGIAPIKFLAKIASEMNKP-----NGQYVIT-PAQVP 170
Cdd:PRK03609 95 VEIYSIDEAFCDLTGVRNCR-DLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwqrqtGGVVDLSnLERQR 173
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 896198631 171 AFLQQLPLSKIPGVGKVTAKRLEEVGLITCADVQQYDLAQLLKRFGkfgrVLWER 225
Cdd:PRK03609 174 KLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFN----VVLER 224
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
166-197 |
2.04e-06 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 43.93 E-value: 2.04e-06
10 20 30
....*....|....*....|....*....|..
gi 896198631 166 PAQVPAFLQQLPLSKIPGVGKVTAKRLEEVGL 197
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| |
