NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|8923466|ref|NP_060319|]
View 

transmembrane protein 127 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TMEM127 pfam20517
Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its ...
 84-196 1.58e-44

Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its interaction with early endosomal GTPase Rab5 to inhibit mTOR signalling seems to be related with its tumour-suppressing properties.


:

Pssm-ID: 466666  Cd Length: 113  Bit Score: 145.09  E-value: 1.58e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923466     84 CMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKK 163
Cdd:pfam20517   1 CVTNEIVLLMRVIIALCFMAIIFSLFGFLLDLFGPNQRALKVIRRNAVGSILTVIWCVAIVGFCYWVTELILDLQRETKL 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 8923466    164 YHGSQVYVTFAVSFYLVAGAGGASILATAANLL 196
Cdd:pfam20517  81 YPGSKVQVSFDVGFYLITAAGALSVLATACNLL 113
 
Name Accession Description Interval E-value
TMEM127 pfam20517
Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its ...
 84-196 1.58e-44

Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its interaction with early endosomal GTPase Rab5 to inhibit mTOR signalling seems to be related with its tumour-suppressing properties.


Pssm-ID: 466666  Cd Length: 113  Bit Score: 145.09  E-value: 1.58e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923466     84 CMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKK 163
Cdd:pfam20517   1 CVTNEIVLLMRVIIALCFMAIIFSLFGFLLDLFGPNQRALKVIRRNAVGSILTVIWCVAIVGFCYWVTELILDLQRETKL 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 8923466    164 YHGSQVYVTFAVSFYLVAGAGGASILATAANLL 196
Cdd:pfam20517  81 YPGSKVQVSFDVGFYLITAAGALSVLATACNLL 113
 
Name Accession Description Interval E-value
TMEM127 pfam20517
Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its ...
 84-196 1.58e-44

Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its interaction with early endosomal GTPase Rab5 to inhibit mTOR signalling seems to be related with its tumour-suppressing properties.


Pssm-ID: 466666  Cd Length: 113  Bit Score: 145.09  E-value: 1.58e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923466     84 CMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKK 163
Cdd:pfam20517   1 CVTNEIVLLMRVIIALCFMAIIFSLFGFLLDLFGPNQRALKVIRRNAVGSILTVIWCVAIVGFCYWVTELILDLQRETKL 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 8923466    164 YHGSQVYVTFAVSFYLVAGAGGASILATAANLL 196
Cdd:pfam20517  81 YPGSKVQVSFDVGFYLITAAGALSVLATACNLL 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH