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Conserved domains on  [gi|884877499|ref|XP_013001742|]
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Fanconi anemia group D2 protein isoform X1 [Cavia porcellus]

Protein Classification

fanconi anemia group D2 protein( domain architecture ID 11235073)

fanconi anemia group D2 protein (FANCD2) is required for maintenance of chromosomal stability, promotion of accurate and efficient pairing of homologs during meiosis, and the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing

Gene Ontology:  GO:0006281|GO:0031573|GO:1990918|GO:0070182

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 35-1412 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


:

Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2393.70  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499    35 SHASNEVEEN--VFVKLLKTSGLILKTGENQNQLVVDQIVFQKKLFQSLKKHPSYPKVIEEFVSGLESHIEDHDTFRNCL 112
Cdd:pfam14631    1 SHAQNEVEENgsVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   113 LPCERLQDEELRcegSTGTSYSKSLIKLLLGIDILQPAIIKTLFEKLPEFLFVKVNSDGISMPRLIISQLKWLDRVVDSK 192
Cdd:pfam14631   81 LPCVPLQSEEAS---SMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGK 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   193 DLTAKVMQLIGIAPECLQHDFITSLPEILGDSQHADVGQELSVLLVESTQLTVPILDVLSSLQLDPDFLSKVRQLAMGKL 272
Cdd:pfam14631  158 DLTSKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   273 VSIKLDDFPVIIKFILHSITATNAFEVISELRRKLDLQHFIFPSLLQASQFTLKRKGGASSSGSQNSSHPDYVTLIFDVI 352
Cdd:pfam14631  238 SAVQLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVI 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   353 KSAVRYEKAISEAWVKAIETTVLGSDHSTFDVVMLFIIYSTSPQTKKYIEKVLRSKIRSGCFHQQLLESTFCVHFMVLED 432
Cdd:pfam14631  318 KSAVRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRD 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   433 VCPSILLVAQNLFHSQEQSITSFASLLYKYSFRSFDTYCQQEVVGALVTHVCSGNEAEVDAALYVLLELSVLDPSAMRLN 512
Cdd:pfam14631  398 YFPSILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLY 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   513 AAFVKGLLDYLDNMSPQQIRKLFHILSTLAFSEQHEASSHIKDDMHLVIRKQLSSSIVKYKLIGIIGAVTMAGIMAAD-- 590
Cdd:pfam14631  478 AVFVKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADrs 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   591 ----SQERVDPSNEQCTQVMSLLQLVQSCSEQSPQASALYYDEFANLIQEGNIAPKTLEWVGQTICSDFQDAFVVDLCDV 666
Cdd:pfam14631  558 ksgsSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPD 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   667 SEGALPFPGKALYGLEEYNTCDGIAINLLPLLYSEEFAKDGGHMTAQESGQKLVSTLCLAPYFRLLRFCVAKQHNGNLEE 746
Cdd:pfam14631  638 IEGDFPFPVKALYGLEEEESQGGIAINLLPLLAKDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEE 717

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   747 IDGLLDCPLFLTDLEPGERLESMPAKERSFLCSLTFLTLNWFREVVNAFCQQPSPEMKGKVLMRLKVIVELQDILEKHLA 826
Cdd:pfam14631  718 IDGLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLA 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   827 VTPDYVPPFAHFDLetldviphsssasaksrskgkirgrkqkaddgkaspaDKLSKEDNSECEPVASGRSQLDKEFTGKE 906
Cdd:pfam14631  798 VTPGYVPPLANFDL-------------------------------------DSSQKEEASEAEESQSEKSQLEKEFKGKE 840

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   907 ARASVSLQNYRAFFRELDIEVFSILRCGLVTKVILDTEMHTEATEVLQLGPPELLFLLEDLSQKLENMLLPSCTKRMSFL 986
Cdd:pfam14631  841 GKTGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFL 920

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   987 KSKGSRNIGFSHLHQSSASEVVNCVVQLVTPMCNHLENIHNYFQCLVPENHgvPTVGGPGGNAQEYQIMSSCYLRLLQIF 1066
Cdd:pfam14631  921 KGKGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENH--GVVDGPGVDVQEHQLMSSCYQLLLQVL 998

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  1067 HWLFAWSGFSNIENHSYLYSALEVLTGRVKQLQPDEALEELLSQSFNYLQNFHNSIPSFQCGLCLIRILMALFKRSVDPA 1146
Cdd:pfam14631  999 HTLFAWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPA 1078

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  1147 PKKEKIAFLARQFLCRVW--PHGEKEKTSVFKDQLQDLLCIYLEHTDSVLKAIEEIAGVGVPELIHSPKDACSPTFPTLT 1224
Cdd:pfam14631 1079 AKREKIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLT 1158

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  1225 RQTFVIFFRVMMAKLEKTVKSLQAGSAVQPPKVHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHACLKYGRLFVEAFLK 1304
Cdd:pfam14631 1159 RQTFLVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLK 1238

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  1305 QCMPLLDFSFRKHREDVLSLLETFQLNTRLLHHLCGHSKIHQDTRLTKHVPLLKKTLEQLVCRVKAMLVLNNCREAFWLG 1384
Cdd:pfam14631 1239 LGMPLLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLG 1318

                         1370      1380
                   ....*....|....*....|....*...
gi 884877499  1385 NLKNRDLQGEEIVSQDSQGSTAEESEDS 1412
Cdd:pfam14631 1319 NLKNRDLQGEEILSQRSQESDEEEEEDS 1346
 
Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 35-1412 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2393.70  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499    35 SHASNEVEEN--VFVKLLKTSGLILKTGENQNQLVVDQIVFQKKLFQSLKKHPSYPKVIEEFVSGLESHIEDHDTFRNCL 112
Cdd:pfam14631    1 SHAQNEVEENgsVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   113 LPCERLQDEELRcegSTGTSYSKSLIKLLLGIDILQPAIIKTLFEKLPEFLFVKVNSDGISMPRLIISQLKWLDRVVDSK 192
Cdd:pfam14631   81 LPCVPLQSEEAS---SMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGK 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   193 DLTAKVMQLIGIAPECLQHDFITSLPEILGDSQHADVGQELSVLLVESTQLTVPILDVLSSLQLDPDFLSKVRQLAMGKL 272
Cdd:pfam14631  158 DLTSKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   273 VSIKLDDFPVIIKFILHSITATNAFEVISELRRKLDLQHFIFPSLLQASQFTLKRKGGASSSGSQNSSHPDYVTLIFDVI 352
Cdd:pfam14631  238 SAVQLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVI 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   353 KSAVRYEKAISEAWVKAIETTVLGSDHSTFDVVMLFIIYSTSPQTKKYIEKVLRSKIRSGCFHQQLLESTFCVHFMVLED 432
Cdd:pfam14631  318 KSAVRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRD 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   433 VCPSILLVAQNLFHSQEQSITSFASLLYKYSFRSFDTYCQQEVVGALVTHVCSGNEAEVDAALYVLLELSVLDPSAMRLN 512
Cdd:pfam14631  398 YFPSILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLY 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   513 AAFVKGLLDYLDNMSPQQIRKLFHILSTLAFSEQHEASSHIKDDMHLVIRKQLSSSIVKYKLIGIIGAVTMAGIMAAD-- 590
Cdd:pfam14631  478 AVFVKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADrs 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   591 ----SQERVDPSNEQCTQVMSLLQLVQSCSEQSPQASALYYDEFANLIQEGNIAPKTLEWVGQTICSDFQDAFVVDLCDV 666
Cdd:pfam14631  558 ksgsSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPD 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   667 SEGALPFPGKALYGLEEYNTCDGIAINLLPLLYSEEFAKDGGHMTAQESGQKLVSTLCLAPYFRLLRFCVAKQHNGNLEE 746
Cdd:pfam14631  638 IEGDFPFPVKALYGLEEEESQGGIAINLLPLLAKDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEE 717

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   747 IDGLLDCPLFLTDLEPGERLESMPAKERSFLCSLTFLTLNWFREVVNAFCQQPSPEMKGKVLMRLKVIVELQDILEKHLA 826
Cdd:pfam14631  718 IDGLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLA 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   827 VTPDYVPPFAHFDLetldviphsssasaksrskgkirgrkqkaddgkaspaDKLSKEDNSECEPVASGRSQLDKEFTGKE 906
Cdd:pfam14631  798 VTPGYVPPLANFDL-------------------------------------DSSQKEEASEAEESQSEKSQLEKEFKGKE 840

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   907 ARASVSLQNYRAFFRELDIEVFSILRCGLVTKVILDTEMHTEATEVLQLGPPELLFLLEDLSQKLENMLLPSCTKRMSFL 986
Cdd:pfam14631  841 GKTGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFL 920

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   987 KSKGSRNIGFSHLHQSSASEVVNCVVQLVTPMCNHLENIHNYFQCLVPENHgvPTVGGPGGNAQEYQIMSSCYLRLLQIF 1066
Cdd:pfam14631  921 KGKGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENH--GVVDGPGVDVQEHQLMSSCYQLLLQVL 998

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  1067 HWLFAWSGFSNIENHSYLYSALEVLTGRVKQLQPDEALEELLSQSFNYLQNFHNSIPSFQCGLCLIRILMALFKRSVDPA 1146
Cdd:pfam14631  999 HTLFAWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPA 1078

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  1147 PKKEKIAFLARQFLCRVW--PHGEKEKTSVFKDQLQDLLCIYLEHTDSVLKAIEEIAGVGVPELIHSPKDACSPTFPTLT 1224
Cdd:pfam14631 1079 AKREKIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLT 1158

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  1225 RQTFVIFFRVMMAKLEKTVKSLQAGSAVQPPKVHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHACLKYGRLFVEAFLK 1304
Cdd:pfam14631 1159 RQTFLVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLK 1238

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  1305 QCMPLLDFSFRKHREDVLSLLETFQLNTRLLHHLCGHSKIHQDTRLTKHVPLLKKTLEQLVCRVKAMLVLNNCREAFWLG 1384
Cdd:pfam14631 1239 LGMPLLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLG 1318

                         1370      1380
                   ....*....|....*....|....*...
gi 884877499  1385 NLKNRDLQGEEIVSQDSQGSTAEESEDS 1412
Cdd:pfam14631 1319 NLKNRDLQGEEILSQRSQESDEEEEEDS 1346
FANCD2 cd11721
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
 88-1399 0e+00

Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.


Pssm-ID: 212595  Cd Length: 1161  Bit Score: 1254.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   88 PKVIEEFVSGLESHIEDHDTFRNCLLPCERLQDEELrcegSTGTSYSKSLIKLLLGIDILQPAIIKTLFEKLPEFLF-VK 166
Cdd:cd11721     1 PENVDEFLSGLEDFLADRDRLRKALLPCNLLTTESS----SASSVPQDSLIRLLLQVDPLQPKVIELLLEKLPEFLDeDA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  167 VNSDGISMPRLIISQLKWLDRVVDSKDLTAKVMQLIGIAPECLQHDFITSLPEILGDSQHADVGQELSVLLVESTQLTVP 246
Cdd:cd11721    77 SVPSEDNLPRLILNQFKWLDHIVDSEDLTEKLLELLSVAPSELQKEIITSLPEIIGDSQHEDVAEELCKLLQENSELTVP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  247 ILDVLSSLQLDPDFLSKVRQLAMGKLVSIKLDDFPVIIKFILHSITATNAFEVISELRRKLDLQHFIFPSLLQASQFTLk 326
Cdd:cd11721   157 ILDALSNLNLSPELLSEIREKVLSCLKTVPLEDLPVLVKFLLQSITATEALEIISKLRKNLDFSPLSDPSSSGSSDKSK- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  327 rkggasssgsqnSSHPDYVTLIFDVIKSAVRYEKAISEAWVKAIETTVLGSDHSTFDVVMLFIIYSTSPQTKKYIEKVLR 406
Cdd:cd11721   236 ------------ASANSCQSLILEAIKSALRFSKLLAEAWIKVISSIDAPQDHKVIDLILLLILYSTNEDKRKSIESLLK 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  407 SKIRSGCFHQQLLESTFCVHFMVLEDVCPSILLVAQNLFHSQEQSITSFASLLYKYSFRSFDTYCQQEVVGALVTHVCSG 486
Cdd:cd11721   304 KKIKSGFIRTSLLDLAFTGHSQVLKDYFKSLLSLADNLLRSAEPVVREFGSHLYKLLFKHFDRYYQQEVVGALITHIGSG 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  487 NEAEVDAALYVLLELSVLDPSAMRLNAAFVKGLLDYLDNMSPQQIRKLFHILSTLAFSEQHEA-SSHIKDDMHLVIRKQL 565
Cdd:cd11721   384 NSSEVDAALDVLRELAEKNPDELLPYATFIKGILDYLDSLNLKQIRQLFDILCHLAFSERPLSeGSSIQDDLHIIVRKQL 463

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  566 SSSIVKYKLIGIIGAVTMAGIMAA----------DSQERVDPSNEQCTQVMSLLQLVQSCSEQSPQASALYYDEFANLI- 634
Cdd:cd11721   464 SNSSPKYKRMGIIGAVTLVKHLASanssddaverSSSNGSSLPDERLKQAANLLELVLSSCKNSPEALALFYDELANIIs 543

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  635 QEGNIAPKTLEWVGQTICSDFQDAFVVDLCDvsegalpfpgkalygleeyntcdgiainllpllyseefakdgghmtaqe 714
Cdd:cd11721   544 QASNLDPKFLEWLGETITEDFQESFVVDLDE------------------------------------------------- 574

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  715 sgqklVSTLCLAPYFRLLRFCVAKQHNGNLEEIDGLLDCPLFLTDLEPGERLESMPAKERSFLCSLTFLTLNWFREVVNA 794
Cdd:cd11721   575 -----TSSAILASLFRLLRLLERSQQGGSLDEIDALLGCPLVLPDFEVDEKFDSLSTEQRSVVLDCLFYAINWFREVINA 649

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  795 FCQQPSPEMKGKVLMRLKVIVELQDILEKHLAVtpdyvppfahfdletldviphsssasaksrskgkirgrkqkaddgka 874
Cdd:cd11721   650 FATQKDASTKKKVLKRLRNLIELEGRLSKLLAH----------------------------------------------- 682

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  875 spadklskednsecepvasgrsqldkeftgkearasvslqnyrAFFRELDIEVFSILRCGLVTKVILdtemHTEATEVLQ 954
Cdd:cd11721   683 -------------------------------------------CYFRELDLEVFSLLKSGLVTDTSL----ELSEEEGVH 715

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  955 LGPPELLFLLEDLSQKLENMLLPSCTKRMSFLKsKGSRNIGFSHLHQSSASEVVNCVVQLVTPMCNHLENIHNYFQCLVP 1034
Cdd:cd11721   716 LGPKELRFLLEDLNRKLEHVLTSPKKKRMPLLK-PLKKGQGFSSLSQKSPKEVLKALVPLLPHLCKHLEKIHNYLQNLLL 794

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499 1035 ENHgvPTVGGPGGNAQEYQIMSSCYLRLLQIFHWLFAWSGFSNIENHSYLYSALEVLTGRVK-QLQPDEALEELLSQSFN 1113
Cdd:cd11721   795 SNA--GQLDAPGPFVQENQYAKSCYGLLLQCLRLLFAWPGFSSQSNRVLLKSALRAIASRLKeSTGKDLPLKELVSSLFK 872

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499 1114 YLQNFHNSIPSFQCGLCLIRILMALFKRSVDPAPKKEKIAFLARQFLCRVWPH--GEKEKTSVFKDQLQDLLCIYLEHTD 1191
Cdd:cd11721   873 YLKSFEPSVPSLSTAVSLVQLLQALMEKSPDRPQLREKLADLARNFLCRQWPDlsGESEKGQKYNDLIDTLLRIYLEHSD 952

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499 1192 SVLKAIEEIAGVGVPELIHSPKD-ACSPTFPTLTRQTFVIFFRVMMAKLEKTVKSLQAgSAVQPPKVHEEKLLYWNMAVR 1270
Cdd:cd11721   953 DPLKKLEEIAGEALPELLEKKKDkDALETFPTLSKSTFPIFFRVLMEALIESVKKILS-SAADTGGGEMERLLLWQSAVR 1031

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499 1271 DFSILINLIKVFDSHPVLHACLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLNTRLLHHLCGHSKIHQDTRL 1350
Cdd:cd11721  1032 VFKALVNLVKTFDKRPVLAICLKYGRLFLKLFLKLGMPLLEKLFKNHKEEVQELLKTLQQSTRYLHHICCHSKIHKDTAL 1111

                        1290      1300      1310      1320
                  ....*....|....*....|....*....|....*....|....*....
gi 884877499 1351 TKHVPLLKKTLEQLVCRVKAMLVLNNCREAFWLGNLKNRDLQGEEIVSQ 1399
Cdd:cd11721  1112 TNHVPALKKSLETLVYRVKAMLVANNCSEAFWMGNLKNKDLQGEEILSQ 1160
 
Name Accession Description Interval E-value
FancD2 pfam14631
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
 35-1412 0e+00

Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.


Pssm-ID: 464225  Cd Length: 1346  Bit Score: 2393.70  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499    35 SHASNEVEEN--VFVKLLKTSGLILKTGENQNQLVVDQIVFQKKLFQSLKKHPSYPKVIEEFVSGLESHIEDHDTFRNCL 112
Cdd:pfam14631    1 SHAQNEVEENgsVFVKLLKTAGVILKTGENQNEIAVDQVIFQKKLQQALRKHPSYPKVIEEFITGLESYIEDRDTFRNCL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   113 LPCERLQDEELRcegSTGTSYSKSLIKLLLGIDILQPAIIKTLFEKLPEFLFVKVNSDGISMPRLIISQLKWLDRVVDSK 192
Cdd:pfam14631   81 LPCVPLQSEEAS---SMVTSYQESLIKLLLGIEILQPAIIKTLFEKLPEFMFESVNSDGLNMPRLIINQLKWLDRIVDGK 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   193 DLTAKVMQLIGIAPECLQHDFITSLPEILGDSQHADVGQELSVLLVESTQLTVPILDVLSSLQLDPDFLSKVRQLAMGKL 272
Cdd:pfam14631  158 DLTSKLMQLISVAPVELQHDIITSLPEILEDSQHNDVARELSSLLVENTQLTVPILDALSSLNLDPTLLSEVRQAVMGTL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   273 VSIKLDDFPVIIKFILHSITATNAFEVISELRRKLDLQHFIFPSLLQASQFTLKRKGGASSSGSQNSSHPDYVTLIFDVI 352
Cdd:pfam14631  238 SAVQLEDLPVVVKFILHSVSATDAYEVISELRKKLDLEQCVLPPVLQASQSKLKSKGAASSSGNQASSSQDCISLVFDVI 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   353 KSAVRYEKAISEAWVKAIETTVLGSDHSTFDVVMLFIIYSTSPQTKKYIEKVLRSKIRSGCFHQQLLESTFCVHFMVLED 432
Cdd:pfam14631  318 KSAVRFQKTISEAWLKAIENIDSVSDHKVLDLLMLFIIYSTNANQKKGIERVLRNKVRSGCIQEQLLQSTFRTHALVLRD 397

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   433 VCPSILLVAQNLFHSQEQSITSFASLLYKYSFRSFDTYCQQEVVGALVTHVCSGNEAEVDAALYVLLELSVLDPSAMRLN 512
Cdd:pfam14631  398 YFPSILALAQSLLHSPDQSIVSFGSHMYKYAFTAFDSYCQQEVVGALVTHVCSGNEAEVDVALELLLELVVLKPSAMRLY 477

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   513 AAFVKGLLDYLDNMSPQQIRKLFHILSTLAFSEQHEASSHIKDDMHLVIRKQLSSSIVKYKLIGIIGAVTMAGIMAAD-- 590
Cdd:pfam14631  478 AVFVKGILDYMDNLTPQQIRKLFHILSTLAFSQQHEQSSHIQDDMHIVIRKQLSSTVPKYKRIGIIGAVTMVGSMAADrs 557

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   591 ----SQERVDPSNEQCTQVMSLLQLVQSCSEQSPQASALYYDEFANLIQEGNIAPKTLEWVGQTICSDFQDAFVVDLCDV 666
Cdd:pfam14631  558 ksgsSSQSASLSKEQCRQVTSLLELVHSCSEQSPQAAALYYDELANLIQKGKLDPKVLEWIGQSVLNDFQDDFVVDLGPD 637

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   667 SEGALPFPGKALYGLEEYNTCDGIAINLLPLLYSEEFAKDGGHMTAQESGQKLVSTLCLAPYFRLLRFCVAKQHNGNLEE 746
Cdd:pfam14631  638 IEGDFPFPVKALYGLEEEESQGGIAINLLPLLAKDEQAKDEGEVTAQEKGQKRVSPLCLSPFFRLLRLCVEKQHDGDLEE 717

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   747 IDGLLDCPLFLTDLEPGERLESMPAKERSFLCSLTFLTLNWFREVVNAFCQQPSPEMKGKVLMRLKVIVELQDILEKHLA 826
Cdd:pfam14631  718 IDGLLGCPLILTDLEVGEKLESLSKKEREFLCSLLFHTINWFREVVNAFCQQKDPEMKGKVLTRLQNITELQSLLEKYLA 797

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   827 VTPDYVPPFAHFDLetldviphsssasaksrskgkirgrkqkaddgkaspaDKLSKEDNSECEPVASGRSQLDKEFTGKE 906
Cdd:pfam14631  798 VTPGYVPPLANFDL-------------------------------------DSSQKEEASEAEESQSEKSQLEKEFKGKE 840

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   907 ARASVSLQNYRAFFRELDIEVFSILRCGLVTKVILDTEMHTEATEVLQLGPPELLFLLEDLSQKLENMLLPSCTKRMSFL 986
Cdd:pfam14631  841 GKTGVSLQSYRAFFRELDIEVFSVLHCGLLTKSLLDTEMHTKAREEVQLGPAELLFLLEDLSRKLEFMLTPAPAKRAPFL 920

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   987 KSKGSRNIGFSHLHQSSASEVVNCVVQLVTPMCNHLENIHNYFQCLVPENHgvPTVGGPGGNAQEYQIMSSCYLRLLQIF 1066
Cdd:pfam14631  921 KGKGDRNVGFSHLQQRSAQEIAHCVVQLLPPLCNHLENIHNYFQCLLAENH--GVVDGPGVDVQEHQLMSSCYQLLLQVL 998

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  1067 HWLFAWSGFSNIENHSYLYSALEVLTGRVKQLQPDEALEELLSQSFNYLQNFHNSIPSFQCGLCLIRILMALFKRSVDPA 1146
Cdd:pfam14631  999 HTLFAWSGFSQPENRSLLKSALGVLAGRLKEGEAELTLEELVSHSFEYLQNFRSSVPSFQCALCLIQLLIVIAEKSGNPA 1078

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  1147 PKKEKIAFLARQFLCRVW--PHGEKEKTSVFKDQLQDLLCIYLEHTDSVLKAIEEIAGVGVPELIHSPKDACSPTFPTLT 1224
Cdd:pfam14631 1079 AKREKIASLARQFLCQVWvtPSGEKEKGNKFNDALHTLLCIYLEHTDDVLKAIEEIAGEGVPELINSSKDASSSTFPTLT 1158

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  1225 RQTFVIFFRVMMAKLEKTVKSLQAGSAVQPPKVHEEKLLYWNMAVRDFSILINLIKVFDSHPVLHACLKYGRLFVEAFLK 1304
Cdd:pfam14631 1159 RQTFLVFFRVMMAELEKSVRKIQPGTASDSQEVQEEKLLYWNMAVRDFHILVNLVKVFDSRPVLHVCLKYGRLFVEAFLK 1238

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  1305 QCMPLLDFSFRKHREDVLSLLETFQLNTRLLHHLCGHSKIHQDTRLTKHVPLLKKTLEQLVCRVKAMLVLNNCREAFWLG 1384
Cdd:pfam14631 1239 LGMPLLDFSFKKHREDVQSLLKTFQLSTRQLHHMCGHSKIHQDTGLTNHVPLLKKSLELFVYRVKAMLVLNNCQEAFWLG 1318

                         1370      1380
                   ....*....|....*....|....*...
gi 884877499  1385 NLKNRDLQGEEIVSQDSQGSTAEESEDS 1412
Cdd:pfam14631 1319 NLKNRDLQGEEILSQRSQESDEEEEEDS 1346
FANCD2 cd11721
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
 88-1399 0e+00

Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.


Pssm-ID: 212595  Cd Length: 1161  Bit Score: 1254.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499   88 PKVIEEFVSGLESHIEDHDTFRNCLLPCERLQDEELrcegSTGTSYSKSLIKLLLGIDILQPAIIKTLFEKLPEFLF-VK 166
Cdd:cd11721     1 PENVDEFLSGLEDFLADRDRLRKALLPCNLLTTESS----SASSVPQDSLIRLLLQVDPLQPKVIELLLEKLPEFLDeDA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  167 VNSDGISMPRLIISQLKWLDRVVDSKDLTAKVMQLIGIAPECLQHDFITSLPEILGDSQHADVGQELSVLLVESTQLTVP 246
Cdd:cd11721    77 SVPSEDNLPRLILNQFKWLDHIVDSEDLTEKLLELLSVAPSELQKEIITSLPEIIGDSQHEDVAEELCKLLQENSELTVP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  247 ILDVLSSLQLDPDFLSKVRQLAMGKLVSIKLDDFPVIIKFILHSITATNAFEVISELRRKLDLQHFIFPSLLQASQFTLk 326
Cdd:cd11721   157 ILDALSNLNLSPELLSEIREKVLSCLKTVPLEDLPVLVKFLLQSITATEALEIISKLRKNLDFSPLSDPSSSGSSDKSK- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  327 rkggasssgsqnSSHPDYVTLIFDVIKSAVRYEKAISEAWVKAIETTVLGSDHSTFDVVMLFIIYSTSPQTKKYIEKVLR 406
Cdd:cd11721   236 ------------ASANSCQSLILEAIKSALRFSKLLAEAWIKVISSIDAPQDHKVIDLILLLILYSTNEDKRKSIESLLK 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  407 SKIRSGCFHQQLLESTFCVHFMVLEDVCPSILLVAQNLFHSQEQSITSFASLLYKYSFRSFDTYCQQEVVGALVTHVCSG 486
Cdd:cd11721   304 KKIKSGFIRTSLLDLAFTGHSQVLKDYFKSLLSLADNLLRSAEPVVREFGSHLYKLLFKHFDRYYQQEVVGALITHIGSG 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  487 NEAEVDAALYVLLELSVLDPSAMRLNAAFVKGLLDYLDNMSPQQIRKLFHILSTLAFSEQHEA-SSHIKDDMHLVIRKQL 565
Cdd:cd11721   384 NSSEVDAALDVLRELAEKNPDELLPYATFIKGILDYLDSLNLKQIRQLFDILCHLAFSERPLSeGSSIQDDLHIIVRKQL 463

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  566 SSSIVKYKLIGIIGAVTMAGIMAA----------DSQERVDPSNEQCTQVMSLLQLVQSCSEQSPQASALYYDEFANLI- 634
Cdd:cd11721   464 SNSSPKYKRMGIIGAVTLVKHLASanssddaverSSSNGSSLPDERLKQAANLLELVLSSCKNSPEALALFYDELANIIs 543

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  635 QEGNIAPKTLEWVGQTICSDFQDAFVVDLCDvsegalpfpgkalygleeyntcdgiainllpllyseefakdgghmtaqe 714
Cdd:cd11721   544 QASNLDPKFLEWLGETITEDFQESFVVDLDE------------------------------------------------- 574

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  715 sgqklVSTLCLAPYFRLLRFCVAKQHNGNLEEIDGLLDCPLFLTDLEPGERLESMPAKERSFLCSLTFLTLNWFREVVNA 794
Cdd:cd11721   575 -----TSSAILASLFRLLRLLERSQQGGSLDEIDALLGCPLVLPDFEVDEKFDSLSTEQRSVVLDCLFYAINWFREVINA 649

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  795 FCQQPSPEMKGKVLMRLKVIVELQDILEKHLAVtpdyvppfahfdletldviphsssasaksrskgkirgrkqkaddgka 874
Cdd:cd11721   650 FATQKDASTKKKVLKRLRNLIELEGRLSKLLAH----------------------------------------------- 682

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  875 spadklskednsecepvasgrsqldkeftgkearasvslqnyrAFFRELDIEVFSILRCGLVTKVILdtemHTEATEVLQ 954
Cdd:cd11721   683 -------------------------------------------CYFRELDLEVFSLLKSGLVTDTSL----ELSEEEGVH 715

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  955 LGPPELLFLLEDLSQKLENMLLPSCTKRMSFLKsKGSRNIGFSHLHQSSASEVVNCVVQLVTPMCNHLENIHNYFQCLVP 1034
Cdd:cd11721   716 LGPKELRFLLEDLNRKLEHVLTSPKKKRMPLLK-PLKKGQGFSSLSQKSPKEVLKALVPLLPHLCKHLEKIHNYLQNLLL 794

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499 1035 ENHgvPTVGGPGGNAQEYQIMSSCYLRLLQIFHWLFAWSGFSNIENHSYLYSALEVLTGRVK-QLQPDEALEELLSQSFN 1113
Cdd:cd11721   795 SNA--GQLDAPGPFVQENQYAKSCYGLLLQCLRLLFAWPGFSSQSNRVLLKSALRAIASRLKeSTGKDLPLKELVSSLFK 872

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499 1114 YLQNFHNSIPSFQCGLCLIRILMALFKRSVDPAPKKEKIAFLARQFLCRVWPH--GEKEKTSVFKDQLQDLLCIYLEHTD 1191
Cdd:cd11721   873 YLKSFEPSVPSLSTAVSLVQLLQALMEKSPDRPQLREKLADLARNFLCRQWPDlsGESEKGQKYNDLIDTLLRIYLEHSD 952

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499 1192 SVLKAIEEIAGVGVPELIHSPKD-ACSPTFPTLTRQTFVIFFRVMMAKLEKTVKSLQAgSAVQPPKVHEEKLLYWNMAVR 1270
Cdd:cd11721   953 DPLKKLEEIAGEALPELLEKKKDkDALETFPTLSKSTFPIFFRVLMEALIESVKKILS-SAADTGGGEMERLLLWQSAVR 1031

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499 1271 DFSILINLIKVFDSHPVLHACLKYGRLFVEAFLKQCMPLLDFSFRKHREDVLSLLETFQLNTRLLHHLCGHSKIHQDTRL 1350
Cdd:cd11721  1032 VFKALVNLVKTFDKRPVLAICLKYGRLFLKLFLKLGMPLLEKLFKNHKEEVQELLKTLQQSTRYLHHICCHSKIHKDTAL 1111

                        1290      1300      1310      1320
                  ....*....|....*....|....*....|....*....|....*....
gi 884877499 1351 TKHVPLLKKTLEQLVCRVKAMLVLNNCREAFWLGNLKNRDLQGEEIVSQ 1399
Cdd:cd11721  1112 TNHVPALKKSLETLVYRVKAMLVANNCSEAFWMGNLKNKDLQGEEILSQ 1160
FANC cd11719
Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of ...
 133-1277 0e+00

Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome.


Pssm-ID: 212593  Cd Length: 977  Bit Score: 933.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  133 YSKSLIKLLLGID----ILQPAIIKTLFEKLPEFLFVKVN-SDGISMPRLIISQLKWLDRVVDSKDLTAKVMQLIGIAPE 207
Cdd:cd11719     2 AVGTLLRAVLKGSpcseEDGALRRYKIYSCCIQLVESGDLqQDVASEIIGLLMLEVHHFPGPLLVDLASDFVGAVREDRL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  208 CLQHDFITSLPEILG-----------------DSQHADVGQELSVLLvESTQLTVPILDVLSSLQLDPDFLSKVRQLAMG 270
Cdd:cd11719    82 VNGKSLELLPIILTAlatkkevlacgkgdlngEEYKRQLIDTLCSVR-WPQRYMIQLTSVFKDVCLTPEEMNLVVAKVLT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  271 KLVSIKLDDFPVIIKFILHS---ITATNAFEVISELRRKLDLQHFIFPSLLQASQFTLKRKGGASssgsqnsshpDYVTL 347
Cdd:cd11719   161 MFSKLNLQEIPPLVYQLLVLsskGSRRSVLDGIIAFFRELDKQHREEQSSDELSELITAPADELY----------HVEGT 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  348 IFDVIKSAVRYE-KAISEAWVKAIE--TTVLGSDHSTFDVVMLFIIYSTSPQTKKYIEKVLRSKIRSGC----------- 413
Cdd:cd11719   231 VILHIVFAIKLDcELGRELLKHLKAgqQGDPSKCLCPFSIALLLSLTRIQRFEEQVFDLLKTSVVKSFKdlqllqgskfl 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  414 --------FHQQLLESTFCVHFMVLEDVCPSILLVAQNLFHS---------------------QEQSITSFASLLYKYSF 464
Cdd:cd11719   311 qtlvpqrtCVSTMILEVVRNSVHSWDHVTQGLIEFGFILMDSygpkkildgkaveigtslskmTNQHACKLGANILLETF 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  465 RsFDTYCQQEVVGALVTHVCSGNEAEVDAALYVLLELSVLDPSAmRLNAAFVKGLLDYLDNMSPQQIRKLFHILSTLAFS 544
Cdd:cd11719   391 K-IHEMIRQEILEQVLNRVVTRTSSPINHFLDLFSDIIMYAPLI-LQNCSKVTETFDYLTFLPLQTVQGLLKAVQPLLKI 468

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  545 EqheasSHIKDDMHLVIRKQLSSSIVKYKLIGIIGAVTMAGIMAAD-------------------SQERVDPSNEQCTQV 605
Cdd:cd11719   469 S-----MSMRDSLILVLRKAMFASQLDARKSAVAGFLLLLKNFKVLgslpssqctqsigvtqvrvDVHSRYSAVANETFC 543

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  606 MSLLQLVQSCSEQSPQASALYYDefanliqEGNIAPKTLEWVGQTICSDFQDAFVVDLCDVSEGALPFPGKAlygleeyn 685
Cdd:cd11719   544 LEIIDSLKRSLGQQADIRLMLYD-------GFYDVLRRNSQLASSIMQTLFSQLKQFYEPEPDLLPPLKLGA-------- 608

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  686 tcdgiainllpllyseefakdgghmTAQESGQKLVSTLCLAPYFRLLRFCVAKQhngnleeidglldcplfltdlepger 765
Cdd:cd11719   609 -------------------------CVLTQGSQIFLQEPLDHLLSCIQHCLAWY-------------------------- 637

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  766 lesmpakersflcsltflTLNWFREVVNAFCQQPSPE-----MKGKVLMRLKVIVELQDIlekhlavtpdyvppfahfdl 840
Cdd:cd11719   638 ------------------ACLIMGVCEVLMEYNFSISnfsksKFEEILSLFTCYKKFSDI-------------------- 679

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  841 etldviphsssasaksrskgkirgrkqkaddgkaspadklskednsecepvasgrsqldkeftgkearasvslqnyraff 920
Cdd:cd11719       --------------------------------------------------------------------------------

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  921 relDIEVFSILRCGLVTKVILDT---EMHTEATEVLQLGPPELLFLLEDLSQKLENMLlpSCTKRMSFLKSKGSRNIGFS 997
Cdd:cd11719   680 ---IFQNLCDITRVLLWRYTSIPtsvEESGKKEKGKSISLLCLEGLQKTFSVVLQFYQ--PKVQQFLQALDVMGTEEEEA 754

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499  998 HLHQssasevvncvvqlvTPMCNHLENIHNYFQCLVPEnhgvptvggPGGNAQEYQIMSSCYLRLLQIFHWLFAwsgfsn 1077
Cdd:cd11719   755 GVTV--------------TQRASFQIRQFQRSLLNLLS---------SEEDDFNSKEALLLIAVLSTLSRLLEP------ 805

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499 1078 ienhsylysalevltgrvkqlqpdealeelLSQSFNYLQNFHN----------SIPSFQCGLCLIRILMALFKRSvdpap 1147
Cdd:cd11719   806 ------------------------------TSPQFVQMLSWTSkickeysqedASFCKSLMNLFFSLHVLYKSPV----- 850

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884877499 1148 kkekiafLARQFLCRVWPHGEK-----------------EKTSVFKDQLQDLLCIYLEhtDSVLKAIEEIAGVGVPElih 1210
Cdd:cd11719   851 -------TLLRDLSQDIHGQLGdidqdveiektdhfavvNLRTAAPTVCLLVLSQAEK--VMQLGTLVTFFHELVQT--- 918

                        1210      1220      1230      1240      1250      1260
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 884877499 1211 spkdacsPTFPTLTRQTFVIFFRVMMAKLEKTVKSLQAGSAvQPPKVHEEKLLYWNMAVRDFSILIN 1277
Cdd:cd11719   919 -------ALPSGSCVDTLLKGLSKIYSTLTAFVKYYLQVCQ-SSRGIPNTVEKLVKLSGSHLTPVCY 977
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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