NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|8815560|gb|AAB24571|]
View 

thyrotropin beta subunit, partial [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 1-78 3.04e-31

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00068:

Pssm-ID: 473907  Cd Length: 107  Bit Score: 105.44  E-value: 3.04e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8815560       1 GYCMTRHINGKLFLPkyALSQDVCTYRDFIYRTVEIPGCPHHVAPYFSYPVALSCKCGKCNTDYSDCTHEAVKTNYCT 78
Cdd:smart00068  32 GYCYTRDPVYKSPLP--PLPQRVCTYRELRYETVRLPGCPPGVDPVVTYPVALSCHCGKCNTDTTDCTVESLGPDSCS 107
 
Name Accession Description Interval E-value
GHB smart00068
Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones ...
 1-78 3.04e-31

Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology.


Pssm-ID: 214502  Cd Length: 107  Bit Score: 105.44  E-value: 3.04e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8815560       1 GYCMTRHINGKLFLPkyALSQDVCTYRDFIYRTVEIPGCPHHVAPYFSYPVALSCKCGKCNTDYSDCTHEAVKTNYCT 78
Cdd:smart00068  32 GYCYTRDPVYKSPLP--PLPQRVCTYRELRYETVRLPGCPPGVDPVVTYPVALSCHCGKCNTDTTDCTVESLGPDSCS 107
GHB_like cd00069
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 1-70 4.01e-27

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


Pssm-ID: 200450  Cd Length: 96  Bit Score: 94.66  E-value: 4.01e-27
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8815560   1 GYCMTRHINGKLFLPKyALSQDVCTYRDFIYRTVEIPGCPHHVAPYFSYPVALSCKCGKCNTDYSDCTHE 70
Cdd:cd00069 28 GRCDTRDPVYKSPPYK-PSHQPVCTYDEWRYETVRLPGCPPGVDPTYTYPVALSCRCGLCNTDTTDCTRL 96
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 1-77 1.22e-25

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 90.93  E-value: 1.22e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8815560      1 GYCMTRhiNGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPHHVAPYFSYPVALSCKCGKCNTDYSDCTHEAVKTNYC 77
Cdd:pfam00007  31 GYCYTR--DPVYKDGRRAVSQRVCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCGNCPTDNSDCTRLSLQPDSC 105
 
Name Accession Description Interval E-value
GHB smart00068
Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones ...
 1-78 3.04e-31

Glycoprotein hormone beta chain homologues; Also called gonadotropins. Glycoprotein hormones consist of two glycosylated chains (alpha and beta) of similar topology.


Pssm-ID: 214502  Cd Length: 107  Bit Score: 105.44  E-value: 3.04e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8815560       1 GYCMTRHINGKLFLPkyALSQDVCTYRDFIYRTVEIPGCPHHVAPYFSYPVALSCKCGKCNTDYSDCTHEAVKTNYCT 78
Cdd:smart00068  32 GYCYTRDPVYKSPLP--PLPQRVCTYRELRYETVRLPGCPPGVDPVVTYPVALSCHCGKCNTDTTDCTVESLGPDSCS 107
GHB_like cd00069
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 1-70 4.01e-27

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


Pssm-ID: 200450  Cd Length: 96  Bit Score: 94.66  E-value: 4.01e-27
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8815560   1 GYCMTRHINGKLFLPKyALSQDVCTYRDFIYRTVEIPGCPHHVAPYFSYPVALSCKCGKCNTDYSDCTHE 70
Cdd:cd00069 28 GRCDTRDPVYKSPPYK-PSHQPVCTYDEWRYETVRLPGCPPGVDPTYTYPVALSCRCGLCNTDTTDCTRL 96
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 1-77 1.22e-25

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 90.93  E-value: 1.22e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8815560      1 GYCMTRhiNGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPHHVAPYFSYPVALSCKCGKCNTDYSDCTHEAVKTNYC 77
Cdd:pfam00007  31 GYCYTR--DPVYKDGRRAVSQRVCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCGNCPTDNSDCTRLSLQPDSC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH