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Conserved domains on  [gi|874269396|gb|AKP69296|]
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urease accessory protein ureg [Riemerella anatipestifer]

Protein Classification

urease accessory protein UreG( domain architecture ID 12943093)

urease accessory protein UreG facilitates the functional incorporation of the urease nickel metallocenter

Gene Ontology:  GO:0005525|GO:0003924|GO:0016151|GO:0006807
PubMed:  29203664|15542602
SCOP:  4003988

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UreG cd05540
urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is ...
 7-170 1.95e-116

urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is an enzyme which catalyzes the decomposition of urea to form ammonia and carbon dioxide. Bacterial urease is a trimer of three subunits which are encoded by genes ureA, ureB, and ureC. Up to four accessory proteins (ureD, ureE, ureF, and ureG) are required for urease catalytical function. UreG may play an important role in nickel incorporation of the urease metallocenter. UreG is a member of the Fer4_NifH superfamily which contains an ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


:

Pssm-ID: 349776  Cd Length: 191  Bit Score: 327.30  E-value: 1.95e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396   7 KIGVAGPVGSGKTALIEALTRKMSEDYSICVVTNDVYTREDAEFMIKNSKLPAERIRGVETGGCPHTAIREDASMNLEAV 86
Cdd:cd05540    2 TVGIGGPVGSGKTALVEALCRALRDKYSIAVVTNDIYTKEDAEFLIRNGALPEERIRGVETGGCPHTAIREDASMNLAAI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396  87 EDLVKNHPDTQIVFIESGGDNLASTFSPDLADVTIFVIDVAEGEKIPRKGGPGITRSDLLLINKVDLAPYVGASIEVMER 166
Cdd:cd05540   82 EELTAKFPDLDLLLVESGGDNLAATFSPELADYIIYVIDVAGGDKIPRKGGPGITQSDLLVINKTDLAPYVGADLDVMER 161


                 ....
gi 874269396 167 DTKK 170
Cdd:cd05540  162 DAKK 165
 
Name Accession Description Interval E-value
UreG cd05540
urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is ...
 7-170 1.95e-116

urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is an enzyme which catalyzes the decomposition of urea to form ammonia and carbon dioxide. Bacterial urease is a trimer of three subunits which are encoded by genes ureA, ureB, and ureC. Up to four accessory proteins (ureD, ureE, ureF, and ureG) are required for urease catalytical function. UreG may play an important role in nickel incorporation of the urease metallocenter. UreG is a member of the Fer4_NifH superfamily which contains an ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


Pssm-ID: 349776  Cd Length: 191  Bit Score: 327.30  E-value: 1.95e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396   7 KIGVAGPVGSGKTALIEALTRKMSEDYSICVVTNDVYTREDAEFMIKNSKLPAERIRGVETGGCPHTAIREDASMNLEAV 86
Cdd:cd05540    2 TVGIGGPVGSGKTALVEALCRALRDKYSIAVVTNDIYTKEDAEFLIRNGALPEERIRGVETGGCPHTAIREDASMNLAAI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396  87 EDLVKNHPDTQIVFIESGGDNLASTFSPDLADVTIFVIDVAEGEKIPRKGGPGITRSDLLLINKVDLAPYVGASIEVMER 166
Cdd:cd05540   82 EELTAKFPDLDLLLVESGGDNLAATFSPELADYIIYVIDVAGGDKIPRKGGPGITQSDLLVINKTDLAPYVGADLDVMER 161


                 ....
gi 874269396 167 DTKK 170
Cdd:cd05540  162 DAKK 165
ureG TIGR00101
urease accessory protein UreG; This model represents UreG, a GTP hydrolase that acts in the ...
 5-170 1.73e-101

urease accessory protein UreG; This model represents UreG, a GTP hydrolase that acts in the assembly of the nickel metallocenter of urease. It is found only in urease-positive species, although some urease-positive species (e.g. Bacillus subtilis) lack this protein. A similar protein, hypB, is an accessory protein for expression of hydrogenase, which also uses nickel. [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 129208  Cd Length: 199  Bit Score: 289.84  E-value: 1.73e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396    5 YVKIGVAGPVGSGKTALIEALTRKMSEDYSICVVTNDVYTREDAEFMIKNSKLPAERIRGVETGGCPHTAIREDASMNLE 84
Cdd:TIGR00101   1 MVKIGVAGPVGSGKTALIEALTRHMSKKYDMAVITNDIYTQEDAEFLCKNSVLPPERIIGVETGGCPHTAIREDASMNLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396   85 AVEDLVKNHPDTQIVFIESGGDNLASTFSPDLADVTIFVIDVAEGEKIPRKGGPGITRSDLLLINKVDLAPYVGASIEVM 164
Cdd:TIGR00101  81 AVEEMHGRFPNLELVFIESGGDNLSATFSPELADFTIFVIDVAEGDKIPRKGGPGITRSDLLVINKIDLAPYVGADLKVM 160


                  ....*.
gi 874269396  165 ERDTKK 170
Cdd:TIGR00101 161 ERDAKK 166
HypB COG0378
Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, ...
 8-170 6.35e-79

Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440147 [Multi-domain]  Cd Length: 200  Bit Score: 232.64  E-value: 6.35e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396   8 IGVAGPVGSGKTALIEALTRKMSEDYSICVVTNDVYTREDAEFMIKNSklpaERIRGVETGGCPHTaireDASMNLEAVE 87
Cdd:COG0378   16 VNLMGSPGSGKTTLLEKTIRALKDRLRIAVIEGDIYTTEDAERLRAAG----VPVVQINTGGCCHL----DASMVLEALE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396  88 DLvkNHPDTQIVFIESGGDNLASTFSPDLADVTIFVIDVAEGEKIPRKGGPGITRSDLLLINKVDLAPYVGASIEVMERD 167
Cdd:COG0378   88 EL--DLPDLDLLFIENVGNLVCPAFFPLGEDLKVVVLSVTEGDDKPRKYPPMFTAADLLVINKIDLAPYVGFDLEVMEED 165


                 ...
gi 874269396 168 TKK 170
Cdd:COG0378  166 ARR 168
cobW pfam02492
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ...
 8-170 6.35e-46

CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.


Pssm-ID: 396860  Cd Length: 179  Bit Score: 148.56  E-value: 6.35e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396    8 IGVAGPVGSGKTALIEALTRKMSEDYSICVVTNDVY-TREDAEFMIKNSKLpaerIRGVETGGCPHTaIREDASMNLEAV 86
Cdd:pfam02492   3 TVITGFLGSGKTTLLNHLLKQNRAGLRIAVIVNEFGeTGIDAELLSETGVL----IVELSNGCICCT-IREDLSMALEAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396   87 EDLVKNhPDtqIVFIESGGdNLASTFS-----------PDLADVTIFVIDV---AEGEKIPRKGGPGITRSDLLLINKVD 152
Cdd:pfam02492  78 LEREGR-LD--VIFIETTG-LAEPAPVaqtflspelrsPVLLDGVITVVDAaneADGEKIPRKAGDQIAFADLIVLNKTD 153

                         170
                  ....*....|....*...
gi 874269396  153 LAPYVgASIEVMERDTKK 170
Cdd:pfam02492 154 LAPEV-ALLEVLEEDLRR 170
PRK10463 PRK10463
hydrogenase nickel incorporation protein HypB; Provisional
 10-162 1.28e-12

hydrogenase nickel incorporation protein HypB; Provisional


Pssm-ID: 182479  Cd Length: 290  Bit Score: 64.06  E-value: 1.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396  10 VAGPvGSGKTALIEALTRKMSEDYSICVVTNDVYTREDAEfMIKNSKLPAERirgVETG-GCpHTaireDASMNLEAVED 88
Cdd:PRK10463 110 VSSP-GSGKTTLLTETLMRLKDSVPCAVIEGDQQTVNDAA-RIRATGTPAIQ---VNTGkGC-HL----DAQMIADAAPR 179

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 874269396  89 LVKNhpDTQIVFIESGGdNLASTFSPDLAD-VTIFVIDVAEGEKIPRKGGPGITRSDLLLINKVDLAPYVGASIE 162
Cdd:PRK10463 180 LPLD--DNGILFIENVG-NLVCPASFDLGEkHKVAVLSVTEGEDKPLKYPHMFAAASLMLLNKVDLLPYLNFDVE 251
 
Name Accession Description Interval E-value
UreG cd05540
urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is ...
 7-170 1.95e-116

urease accessory protein UreG; UreG is one of the four accessory proteins of urease. Urease is an enzyme which catalyzes the decomposition of urea to form ammonia and carbon dioxide. Bacterial urease is a trimer of three subunits which are encoded by genes ureA, ureB, and ureC. Up to four accessory proteins (ureD, ureE, ureF, and ureG) are required for urease catalytical function. UreG may play an important role in nickel incorporation of the urease metallocenter. UreG is a member of the Fer4_NifH superfamily which contains an ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.


Pssm-ID: 349776  Cd Length: 191  Bit Score: 327.30  E-value: 1.95e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396   7 KIGVAGPVGSGKTALIEALTRKMSEDYSICVVTNDVYTREDAEFMIKNSKLPAERIRGVETGGCPHTAIREDASMNLEAV 86
Cdd:cd05540    2 TVGIGGPVGSGKTALVEALCRALRDKYSIAVVTNDIYTKEDAEFLIRNGALPEERIRGVETGGCPHTAIREDASMNLAAI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396  87 EDLVKNHPDTQIVFIESGGDNLASTFSPDLADVTIFVIDVAEGEKIPRKGGPGITRSDLLLINKVDLAPYVGASIEVMER 166
Cdd:cd05540   82 EELTAKFPDLDLLLVESGGDNLAATFSPELADYIIYVIDVAGGDKIPRKGGPGITQSDLLVINKTDLAPYVGADLDVMER 161


                 ....
gi 874269396 167 DTKK 170
Cdd:cd05540  162 DAKK 165
ureG TIGR00101
urease accessory protein UreG; This model represents UreG, a GTP hydrolase that acts in the ...
 5-170 1.73e-101

urease accessory protein UreG; This model represents UreG, a GTP hydrolase that acts in the assembly of the nickel metallocenter of urease. It is found only in urease-positive species, although some urease-positive species (e.g. Bacillus subtilis) lack this protein. A similar protein, hypB, is an accessory protein for expression of hydrogenase, which also uses nickel. [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 129208  Cd Length: 199  Bit Score: 289.84  E-value: 1.73e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396    5 YVKIGVAGPVGSGKTALIEALTRKMSEDYSICVVTNDVYTREDAEFMIKNSKLPAERIRGVETGGCPHTAIREDASMNLE 84
Cdd:TIGR00101   1 MVKIGVAGPVGSGKTALIEALTRHMSKKYDMAVITNDIYTQEDAEFLCKNSVLPPERIIGVETGGCPHTAIREDASMNLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396   85 AVEDLVKNHPDTQIVFIESGGDNLASTFSPDLADVTIFVIDVAEGEKIPRKGGPGITRSDLLLINKVDLAPYVGASIEVM 164
Cdd:TIGR00101  81 AVEEMHGRFPNLELVFIESGGDNLSATFSPELADFTIFVIDVAEGDKIPRKGGPGITRSDLLVINKIDLAPYVGADLKVM 160


                  ....*.
gi 874269396  165 ERDTKK 170
Cdd:TIGR00101 161 ERDAKK 166
HypB COG0378
Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, ...
 8-170 6.35e-79

Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440147 [Multi-domain]  Cd Length: 200  Bit Score: 232.64  E-value: 6.35e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396   8 IGVAGPVGSGKTALIEALTRKMSEDYSICVVTNDVYTREDAEFMIKNSklpaERIRGVETGGCPHTaireDASMNLEAVE 87
Cdd:COG0378   16 VNLMGSPGSGKTTLLEKTIRALKDRLRIAVIEGDIYTTEDAERLRAAG----VPVVQINTGGCCHL----DASMVLEALE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396  88 DLvkNHPDTQIVFIESGGDNLASTFSPDLADVTIFVIDVAEGEKIPRKGGPGITRSDLLLINKVDLAPYVGASIEVMERD 167
Cdd:COG0378   88 EL--DLPDLDLLFIENVGNLVCPAFFPLGEDLKVVVLSVTEGDDKPRKYPPMFTAADLLVINKIDLAPYVGFDLEVMEED 165


                 ...
gi 874269396 168 TKK 170
Cdd:COG0378  166 ARR 168
cobW pfam02492
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ...
 8-170 6.35e-46

CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.


Pssm-ID: 396860  Cd Length: 179  Bit Score: 148.56  E-value: 6.35e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396    8 IGVAGPVGSGKTALIEALTRKMSEDYSICVVTNDVY-TREDAEFMIKNSKLpaerIRGVETGGCPHTaIREDASMNLEAV 86
Cdd:pfam02492   3 TVITGFLGSGKTTLLNHLLKQNRAGLRIAVIVNEFGeTGIDAELLSETGVL----IVELSNGCICCT-IREDLSMALEAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396   87 EDLVKNhPDtqIVFIESGGdNLASTFS-----------PDLADVTIFVIDV---AEGEKIPRKGGPGITRSDLLLINKVD 152
Cdd:pfam02492  78 LEREGR-LD--VIFIETTG-LAEPAPVaqtflspelrsPVLLDGVITVVDAaneADGEKIPRKAGDQIAFADLIVLNKTD 153

                         170
                  ....*....|....*...
gi 874269396  153 LAPYVgASIEVMERDTKK 170
Cdd:pfam02492 154 LAPEV-ALLEVLEEDLRR 170
HypB cd05390
nickel incorporation protein HypB; HypB is one of numerous accessory proteins required for the ...
 15-170 1.14e-21

nickel incorporation protein HypB; HypB is one of numerous accessory proteins required for the maturation of nickel-dependent hydrogenases, like carbon monoxide dehydrogenase or urease. HypB is a GTP-binding protein and has GTP hyrolase activity. It forms homodimer and is capable of binding two nickel ions and two zinc ions. The active site is located on the dimer interface. Energy from hydrolysis of GTP is used to insert nickels into hydrogenases.


Pssm-ID: 349775  Cd Length: 203  Bit Score: 86.88  E-value: 1.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396  15 GSGKTALIEALTRKMSEDYSICVVTNDVYTREDAEfMIKNSKLPAERIRgveTGGCPHTaireDASMNLEAVEDLvkNHP 94
Cdd:cd05390   31 GSGKTTLLERTIDALKDELKIAVIEGDLETDNDAE-RIRATGVPAIQIN---TGGACHL----DADMVARALHDL--DLD 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 874269396  95 DTQIVFIESGGdNLASTFSPDL-ADVTIFVIDVAEGEKIPRKGGPGITRSDLLLINKVDLAPYVGASIEVMERDTKK 170
Cdd:cd05390  101 ELDLLFIENVG-NLVCPAEFDLgEHKNVVLLSVTEGDDKPLKYPLMFQVADVVLINKIDLLPYFDFDVEKAKEDIKK 176
PRK10463 PRK10463
hydrogenase nickel incorporation protein HypB; Provisional
 10-162 1.28e-12

hydrogenase nickel incorporation protein HypB; Provisional


Pssm-ID: 182479  Cd Length: 290  Bit Score: 64.06  E-value: 1.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396  10 VAGPvGSGKTALIEALTRKMSEDYSICVVTNDVYTREDAEfMIKNSKLPAERirgVETG-GCpHTaireDASMNLEAVED 88
Cdd:PRK10463 110 VSSP-GSGKTTLLTETLMRLKDSVPCAVIEGDQQTVNDAA-RIRATGTPAIQ---VNTGkGC-HL----DAQMIADAAPR 179

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 874269396  89 LVKNhpDTQIVFIESGGdNLASTFSPDLAD-VTIFVIDVAEGEKIPRKGGPGITRSDLLLINKVDLAPYVGASIE 162
Cdd:PRK10463 180 LPLD--DNGILFIENVG-NLVCPASFDLGEkHKVAVLSVTEGEDKPLKYPHMFAAASLMLLNKVDLLPYLNFDVE 251
CobW-like cd03112
cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino ...
 15-155 7.66e-05

cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage caused by mitomycin. YijA gene is a homologue of the CobW gene which encodes the cobalamin synthesis protein/P47K.


Pssm-ID: 349766  Cd Length: 198  Bit Score: 41.35  E-value: 7.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396  15 GSGKTALI-EALTRKmsEDYSICVVTNDVytredAEFMIkNSKLPAERIRGVE----TGGCPHTAIREDAsmnLEAVEDL 89
Cdd:cd03112   10 GAGKTTLLnHILSEQ--HGKRIAVIVNEF-----GEVGI-DAALLADSGGGEEvvelSNGCICCTLKGDL---VKALEQL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396  90 VKNHPDTQIVFIESGG--D--NLASTFSPDLA-------DVTIFVIDVAEGEKIPRKGGPG------ITRSDLLLINKVD 152
Cdd:cd03112   79 LERRGKFDYILIETTGlaDpgPIAQTLWSDEElesrlrlDGVVTVVDAKNFLKQLDEEDVSdlavdqIAFADVIVLNKTD 158


                 ...
gi 874269396 153 LAP 155
Cdd:cd03112  159 LVD 161
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 8-40 1.04e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 38.23  E-value: 1.04e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 874269396   8 IGVAGPVGSGKTALIEALTRKMSEDYSICVVTN 40
Cdd:COG3267   46 VVLTGEVGTGKTTLLRRLLERLPDDVKVAYIPN 78
GTP_EFTU pfam00009
Elongation factor Tu GTP binding domain; This domain contains a P-loop motif, also found in ...
 4-156 2.60e-03

Elongation factor Tu GTP binding domain; This domain contains a P-loop motif, also found in several other families such as pfam00071, pfam00025 and pfam00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.


Pssm-ID: 425418 [Multi-domain]  Cd Length: 187  Bit Score: 36.73  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396    4 PYVKIGVAGPVGSGKTALIEALTRKMSEDYSICVVTNDVYTREDaefmiknsKLPAERIRGVetggcphtairedaSMNL 83
Cdd:pfam00009   2 RHRNIGIIGHVDHGKTTLTDRLLYYTGAISKRGEVKGEGEAGLD--------NLPEERERGI--------------TIKS 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396   84 EAVEDLVKNHpdtQIVFIESGG--DnlastFSPD------LADVTIFVIDVAEG--------------EKIPRkggpgit 141
Cdd:pfam00009  60 AAVSFETKDY---LINLIDTPGhvD-----FVKEvirglaQADGAILVVDAVEGvmpqtrehlrlarqLGVPI------- 124

                         170
                  ....*....|....*
gi 874269396  142 rsdLLLINKVDLAPY 156
Cdd:pfam00009 125 ---IVFINKMDRVDG 136
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 9-155 4.94e-03

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 35.90  E-value: 4.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396   9 GVAGPVGSGKTALIEALTRKMSEDYSICVVTndvyTReDAEFMIKNSKLPAERIRGVETGGcphtAIREDASMNLEAVED 88
Cdd:cd00882    1 VVVGRGGVGKSSLLNALLGGEVGEVSDVPGT----TR-DPDVYVKELDKGKVKLVLVDTPG----LDEFGGLGREELARL 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 874269396  89 LVKnhpDTQIVFIesggdNLASTFSPDLADVTIFVIDVAEGEKIPRkggpgitrsdLLLINKVDLAP 155
Cdd:cd00882   72 LLR---GADLILL-----VVDSTDRESEEDAKLLILRRLRKEGIPI----------ILVGNKIDLLE 120
PRK07429 PRK07429
phosphoribulokinase; Provisional
 1-47 5.43e-03

phosphoribulokinase; Provisional


Pssm-ID: 180975  Cd Length: 327  Bit Score: 36.14  E-value: 5.43e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 874269396   1 MSRPyVKIGVAGPVGSGKTALIEALTRKMSEDY--SICVvtnDVYTRED 47
Cdd:PRK07429   5 PDRP-VLLGVAGDSGCGKTTFLRGLADLLGEELvtVICT---DDYHSYD 49
YejR COG0523
Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction ...
 15-155 5.60e-03

Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction only];


Pssm-ID: 440289 [Multi-domain]  Cd Length: 318  Bit Score: 36.30  E-value: 5.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396  15 GSGKTALIEALtRKMSEDYSICVVTNDVytRE---DAEFMIKnsklPAERIrgVE-TGGCPHTAIREDAsmnLEAVEDLV 90
Cdd:COG0523   14 GAGKTTLLNHL-LANPEGRRIAVIVNEF--GEvgiDAALVRD----TDEEI--VElSNGCICCTLREDL---LPALRRLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269396  91 KNHPDTQIVfIE-SG-GD--NLASTFS--PDLADV-----TIFVIDVAEGEKiPRKGGPG-------ITRSDLLLINKVD 152
Cdd:COG0523   82 RRGRFDRLL-IEtTGlADpaPVAQTFTfdPELRDRlrldgVVTVVDARNLLD-DLADRTLhellvdqIAFADVIVLNKTD 159


                 ...
gi 874269396 153 LAP 155
Cdd:COG0523  160 LVD 162
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 3-76 6.42e-03

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 35.63  E-value: 6.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 874269396    3 RPYVKIGVAGPVGSGKTALIEALTRKMSedysicvVTNDVYTREDA-EFMIKN--SKL--PAERIRGVETGGCPHTAIR 76
Cdd:pfam07724   1 RPIGSFLFLGPTGVGKTELAKALAELLF-------GDERALIRIDMsEYMEEHsvSRLigAPPGYVGYEEGGQLTEAVR 72
CoaA COG1072
Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the ...
 3-41 6.82e-03

Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440690  Cd Length: 309  Bit Score: 36.04  E-value: 6.82e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 874269396   3 RPYVkIGVAGPVGSGKT---ALIEALTRKMSEDYSICVVTND 41
Cdd:COG1072   85 TPFI-IGIAGSVAVGKSttaRLLQALLSRWPEHPKVELVTTD 125
MobB COG1763
Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; ...
 8-38 6.94e-03

Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 441369 [Multi-domain]  Cd Length: 162  Bit Score: 35.16  E-value: 6.94e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 874269396   8 IGVAGPVGSGKTALIEALTRKMSED-YSICVV 38
Cdd:COG1763    4 LGIVGYSGSGKTTLLEKLIPELKARgLRVGTI 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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