NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|874269245|gb|AKP69145|]
View 

putative glycosyltransferase [Riemerella anatipestifer]

Protein Classification

glycosyltransferase( domain architecture ID 12935224)

glycosyltransferase catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
210-349 2.32e-26

Glycosyl transferases group 1;


:

Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 102.59  E-value: 2.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245  210 PIRLISVGSLDQMYKSPEIALQVVHKLVNKGINVHLTWLGKGvfMEDMLKlSQELNIQDKVYFLGAVSamEVKRQLDQSD 289
Cdd:pfam13692   1 RPVILFVGRLHPNVKGVDYLLEAVPLLRKRDNDVRLVIVGDG--PEEELE-ELAAGLEDRVIFTGFVE--DLAELLAAAD 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 874269245  290 IFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELIS--TECLVEVGAIDEVCDIIETMIE 349
Cdd:pfam13692  76 VFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPELVDgeNGLLVPPGDPEALAEAILRLLE 137
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 67-349 5.52e-25

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 104.54  E-value: 5.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245  67 KEIQPFDNPFSFYRHKGKIKKQLIQYLQNQKEAVVIIRGGGALCYLAsqiCHKMAIPYGMEVIGDPYEVFAPGVLKHPLR 146
Cdd:cd03801   52 GVIVPLLPSLAALLRARRLLRELRPLLRLRKFDVVHAHGLLAALLAA---LLALLLGAPLVVTLHGAEPGRLLLLLAAER 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 147 PVLRHLFtkyqkEMVYQASSVIYVT---KEALQKRYPVRESVFTT--YASDVFVSEVSGKERTLISSHPIRLISVGSLDQ 221
Cdd:cd03801  129 RLLARAE-----ALLRRADAVIAVSealRDELRALGGIPPEKIVVipNGVDLERFSPPLRRKLGIPPDRPVLLFVGRLSP 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 222 MyKSPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKlSQELNIQDKVYFLGAVSAMEVKRQLDQSDIFILLSKTEGLP 301
Cdd:cd03801  204 R-KGVDLLLEALAKLLRRGPDVRLVIVGGDGPLRAELE-ELELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFG 281

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 874269245 302 RAMVEAMSRGLPCIGTKVGGIPELISTE---CLVEVGAIDEVCDIIETMIE 349
Cdd:cd03801  282 LVVLEAMAAGLPVVATDVGGLPEVVEDGeggLVVPPDDVEALADALLRLLA 332
 
Name Accession Description Interval E-value
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
210-349 2.32e-26

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 102.59  E-value: 2.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245  210 PIRLISVGSLDQMYKSPEIALQVVHKLVNKGINVHLTWLGKGvfMEDMLKlSQELNIQDKVYFLGAVSamEVKRQLDQSD 289
Cdd:pfam13692   1 RPVILFVGRLHPNVKGVDYLLEAVPLLRKRDNDVRLVIVGDG--PEEELE-ELAAGLEDRVIFTGFVE--DLAELLAAAD 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 874269245  290 IFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELIS--TECLVEVGAIDEVCDIIETMIE 349
Cdd:pfam13692  76 VFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPELVDgeNGLLVPPGDPEALAEAILRLLE 137
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 151-350 5.43e-26

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 107.06  E-value: 5.43e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 151 HLFTKYQKEMVYQASSVIYVT---KEALQKRYPVRESVFTTYASDVFVSEV---SGKERTLISSHPIRLISVGSLDqMYK 224
Cdd:cd03811  123 KKKLLLKLKLYKKADKIVCVSkgiKEDLIRLGPSPPEKIEVIYNPIDIDRIralAKEPILNEPEDGPVILAVGRLD-PQK 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 225 SPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSAmeVKRQLDQSDIFILLSKTEGLPRAM 304
Cdd:cd03811  202 GHDLLIEAFAKLRKKYPDVKLVILGDGPLREELEKLAKELGLAERVIFLGFQSN--PYPYLKKADLFVLSSRYEGFPNVL 279

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 874269245 305 VEAMSRGLPCIGTKVGGIPELI---STECLVEVGAIDEVCDIIETMIEK 350
Cdd:cd03811  280 LEAMALGTPVVSTDCPGPREILddgENGLLVPDGDAAALAGILAALLQK 328
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 67-349 5.52e-25

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 104.54  E-value: 5.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245  67 KEIQPFDNPFSFYRHKGKIKKQLIQYLQNQKEAVVIIRGGGALCYLAsqiCHKMAIPYGMEVIGDPYEVFAPGVLKHPLR 146
Cdd:cd03801   52 GVIVPLLPSLAALLRARRLLRELRPLLRLRKFDVVHAHGLLAALLAA---LLALLLGAPLVVTLHGAEPGRLLLLLAAER 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 147 PVLRHLFtkyqkEMVYQASSVIYVT---KEALQKRYPVRESVFTT--YASDVFVSEVSGKERTLISSHPIRLISVGSLDQ 221
Cdd:cd03801  129 RLLARAE-----ALLRRADAVIAVSealRDELRALGGIPPEKIVVipNGVDLERFSPPLRRKLGIPPDRPVLLFVGRLSP 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 222 MyKSPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKlSQELNIQDKVYFLGAVSAMEVKRQLDQSDIFILLSKTEGLP 301
Cdd:cd03801  204 R-KGVDLLLEALAKLLRRGPDVRLVIVGGDGPLRAELE-ELELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFG 281

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 874269245 302 RAMVEAMSRGLPCIGTKVGGIPELISTE---CLVEVGAIDEVCDIIETMIE 349
Cdd:cd03801  282 LVVLEAMAAGLPVVATDVGGLPEVVEDGeggLVVPPDDVEALADALLRLLA 332
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 285-386 1.40e-13

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 66.94  E-value: 1.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 285 LDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELIS---TECLVEVGAIDEVCDIIETMIEKTSFYQDKSKEN 361
Cdd:COG0438   18 LAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEdgeTGLLVPPGDPEALAEAILRLLEDPELRRRLGEAA 97

                         90       100
                 ....*....|....*....|....*
gi 874269245 362 LDRSKEYLNdfLERKREQFFEYLKK 386
Cdd:COG0438   98 RERAEERFS--WEAIAERLLALYEE 120
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
242-375 1.02e-09

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 59.72  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 242 NVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSAM--EVKRQLDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKV 319
Cdd:PRK09922 210 EWQLHIIGDGSDFEKCKAYSRELGIEQRIIWHGWQSQPweVVQQKIKNVSALLLTSKFEGFPMTLLEAMSYGIPCISSDC 289

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 320 GGIPELISTEC----LVEVGAIDEVCDIIETMIEKTSFYQDKSKENlDRSKEYLNDFLER 375
Cdd:PRK09922 290 MSGPRDIIKPGlngeLYTPGNIDEFVGKLNKVISGEVKYQHDAIPN-SIERFYEVLYFKN 348
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 215-326 2.43e-08

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 55.50  E-value: 2.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245  215 SVGSLdQMYKSPEIALQVVHKLVNKG----INVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGavSAMEVKRQLDQSDI 290
Cdd:TIGR03088 199 TVGRL-QAVKDQPTLVRAFALLVRQLpegaERLRLVIVGDGPARGACEQMVRAAGLAHLVWLPG--ERDDVPALMQALDL 275

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 874269245  291 FILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELI 326
Cdd:TIGR03088 276 FVLPSLAEGISNTILEAMASGLPVIATAVGGNPELV 311
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 260-326 1.15e-04

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 44.15  E-value: 1.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 874269245 260 LSQELNIQDKVYFLGAVSAMEVkrqLDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELI 326
Cdd:NF038011 359 LVASLGLQDKVKFLGFQKIDDL---LPQVGLMVLSSISEALPLVVLEAFAAGVPVVTTDVGSCRQLI 422
 
Name Accession Description Interval E-value
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
210-349 2.32e-26

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 102.59  E-value: 2.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245  210 PIRLISVGSLDQMYKSPEIALQVVHKLVNKGINVHLTWLGKGvfMEDMLKlSQELNIQDKVYFLGAVSamEVKRQLDQSD 289
Cdd:pfam13692   1 RPVILFVGRLHPNVKGVDYLLEAVPLLRKRDNDVRLVIVGDG--PEEELE-ELAAGLEDRVIFTGFVE--DLAELLAAAD 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 874269245  290 IFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELIS--TECLVEVGAIDEVCDIIETMIE 349
Cdd:pfam13692  76 VFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPELVDgeNGLLVPPGDPEALAEAILRLLE 137
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 151-350 5.43e-26

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 107.06  E-value: 5.43e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 151 HLFTKYQKEMVYQASSVIYVT---KEALQKRYPVRESVFTTYASDVFVSEV---SGKERTLISSHPIRLISVGSLDqMYK 224
Cdd:cd03811  123 KKKLLLKLKLYKKADKIVCVSkgiKEDLIRLGPSPPEKIEVIYNPIDIDRIralAKEPILNEPEDGPVILAVGRLD-PQK 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 225 SPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSAmeVKRQLDQSDIFILLSKTEGLPRAM 304
Cdd:cd03811  202 GHDLLIEAFAKLRKKYPDVKLVILGDGPLREELEKLAKELGLAERVIFLGFQSN--PYPYLKKADLFVLSSRYEGFPNVL 279

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 874269245 305 VEAMSRGLPCIGTKVGGIPELI---STECLVEVGAIDEVCDIIETMIEK 350
Cdd:cd03811  280 LEAMALGTPVVSTDCPGPREILddgENGLLVPDGDAAALAGILAALLQK 328
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 67-349 5.52e-25

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 104.54  E-value: 5.52e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245  67 KEIQPFDNPFSFYRHKGKIKKQLIQYLQNQKEAVVIIRGGGALCYLAsqiCHKMAIPYGMEVIGDPYEVFAPGVLKHPLR 146
Cdd:cd03801   52 GVIVPLLPSLAALLRARRLLRELRPLLRLRKFDVVHAHGLLAALLAA---LLALLLGAPLVVTLHGAEPGRLLLLLAAER 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 147 PVLRHLFtkyqkEMVYQASSVIYVT---KEALQKRYPVRESVFTT--YASDVFVSEVSGKERTLISSHPIRLISVGSLDQ 221
Cdd:cd03801  129 RLLARAE-----ALLRRADAVIAVSealRDELRALGGIPPEKIVVipNGVDLERFSPPLRRKLGIPPDRPVLLFVGRLSP 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 222 MyKSPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKlSQELNIQDKVYFLGAVSAMEVKRQLDQSDIFILLSKTEGLP 301
Cdd:cd03801  204 R-KGVDLLLEALAKLLRRGPDVRLVIVGGDGPLRAELE-ELELGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFG 281

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 874269245 302 RAMVEAMSRGLPCIGTKVGGIPELISTE---CLVEVGAIDEVCDIIETMIE 349
Cdd:cd03801  282 LVVLEAMAAGLPVVATDVGGLPEVVEDGeggLVVPPDDVEALADALLRLLA 332
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 210-349 1.33e-22

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 93.11  E-value: 1.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245  210 PIRLISVGSLDQMyKSPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSAMEVKRQLDQSD 289
Cdd:pfam00534   2 KKIILFVGRLEPE-KGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 874269245  290 IFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELIS---TECLVEVGAIDEVCDIIETMIE 349
Cdd:pfam00534  81 VFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKdgeTGFLVKPNNAEALAEAIDKLLE 143
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 201-326 1.78e-22

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 97.14  E-value: 1.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 201 KERTLISSHPIRLISVGSLDQMyKSPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSAME 280
Cdd:cd03799  165 KPRYLPLDGKIRILTVGRLTEK-KGLEYAIEAVAKLAQKYPNIEYQIIGDGDLKEQLQQLIQELNIGDCVKLLGWKPQEE 243

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 874269245 281 VKRQLDQSDIFILLSKT------EGLPRAMVEAMSRGLPCIGTKVGGIPELI 326
Cdd:cd03799  244 IIEILDEADIFIAPSVTaadgdqDGPPNTLKEAMAMGLPVISTEHGGIPELV 295
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 206-349 1.01e-21

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 95.35  E-value: 1.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 206 ISSHPIRLISVGSLDQMyKSPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSamEVKRQL 285
Cdd:cd03808  185 LPSEKVVFLFVARLLKD-KGIDELIEAAKILKKKGPNVRFLLVGDGELENPSEILIEKLGLEGRIEFLGFRS--DVPELL 261

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 874269245 286 DQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELIS---TECLVEVGAIDEVCDIIETMIE 349
Cdd:cd03808  262 AESDVFVLPSYREGLPRSLLEAMAAGRPVITTDVPGCRELVIdgvNGFLVPPGDVEALADAIEKLIE 328
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 71-371 2.80e-21

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 93.92  E-value: 2.80e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245  71 PFDNPFSFYRhkgkikkqLIQYLQNQKEAVVIIRGGGALCY--LASQICHKMAIPYGMEVIGDPYEvfapgvlKHPLRPV 148
Cdd:cd03807   61 SGKDPGVLLR--------LAKLIRKRNPDVVHTWMYHADLIggLAAKLAGGVKVIWSVRSSNIPQR-------LTRLVRK 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 149 LRHLFTKYQKEMVYQASSVIYVTKEALQKRYPVReSVFTTYASDVF----VSEVSGKERTLISSHPIRLISVGSLDQMyK 224
Cdd:cd03807  126 LCLLLSKFSPATVANSSAVAEFHQEQGYAKNKIV-VIYNGIDLFKLspddASRARARRRLGLAEDRRVIGIVGRLHPV-K 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 225 SPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSamEVKRQLDQSDIFILLSKTEGLPRAM 304
Cdd:cd03807  204 DHSDLLRAAALLVETHPDLRLLLVGRGPERPNLERLLLELGLEDRVHLLGERS--DVPALLPAMDIFVLSSRTEGFPNAL 281

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 874269245 305 VEAMSRGLPCIGTKVGGIPELI--STECLVEVGAIDEVCDIIETMIEKtsfyQDKSKENLDRSKEYLND 371
Cdd:cd03807  282 LEAMACGLPVVATDVGGAAELVddGTGFLVPAGDPQALADAIRALLED----PEKRARLGRAARERIAN 346
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 185-326 4.64e-20

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 88.23  E-value: 4.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 185 VFTTYASDVFVSEVSGKERTLISSHPIRL---ISVGSLDQmYKSPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKLS 261
Cdd:cd01635   82 VVTVHGPDSLESTRSELLALARLLVSLPLadkVSVGRLVP-EKGIDLLLEALALLKARLPDLVLVLVGGGGEREEEEALA 160

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 874269245 262 QELNIQDKVYFLGAVSAMEVKR-QLDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELI 326
Cdd:cd01635  161 AALGLLERVVIIGGLVDDEVLElLLAAADVFVLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFV 226
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 112-343 8.08e-20

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 90.13  E-value: 8.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 112 LASQICHKMA-IPYGMEVIGDPYEVFAPGVLKHPL-RPVLRHlftkyqkemvyqASSVIYVTK---EALQKRYPVRESVF 186
Cdd:cd03798  109 FAAALLARLYgVPYVVTEHGSDINVFPPRSLLRKLlRWALRR------------AARVIAVSKalaEELVALGVPRDRVD 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 187 TTYASdVFVSEVSGKERTLISSHPIRLI-SVGSLDQMyKSPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKLSQELN 265
Cdd:cd03798  177 VIPNG-VDPARFQPEDRGLGLPLDAFVIlFVGRLIPR-KGIDLLLEAFARLAKARPDVVLLIVGDGPLREALRALAEDLG 254

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 874269245 266 IQDKVYFLGAVSAMEVKRQLDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELISTEclvEVGAIDEVCDI 343
Cdd:cd03798  255 LGDRVTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDP---ETGLLVPPGDA 329
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 205-370 3.74e-19

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 87.73  E-value: 3.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 205 LISSHPIRLISVGSLDQMyKSPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSamEVKRQ 284
Cdd:cd03812  186 LILEDKLVLGHVGRFNEQ-KNHSFLIDIFEELKKKNPNVKLVLVGEGELKEKIKEKVKELGLEDKVIFLGFRN--DVSEI 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 285 LDQSDIFILLSKTEGLPRAMVEAMSRGLPC-----------IGTKVGGIPelISTECLVEVGAIDEVCDIIETMIEKTSF 353
Cdd:cd03812  263 LSAMDVFLFPSLYEGLPLVAVEAQASGLPCllsdtitkecdITNNVEFLP--LNETPSTWAEKILKLIKRKRRINKEINK 340

                        170
                 ....*....|....*..
gi 874269245 354 YQDKSKENLDRSKEYLN 370
Cdd:cd03812  341 EKKELGYDDESLELTLL 357
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 224-386 6.06e-17

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 81.63  E-value: 6.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 224 KSPEIALQVVHKLVNKgINVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSamEVKRQLDQSDIFILLSKTEGLPRA 303
Cdd:cd04962  209 KRIDDVVRVFARVRRK-IPAKLLLVGDGPERVPAEELARELGVEDRVLFLGKQD--DVEELLSIADLFLLPSEKESFGLA 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 304 MVEAMSRGLPCIGTKVGGIPELIS---TECLVEVGAIDEVCDIIETMIEKTSFYQDKSKENLDRSKEYLNdfLERKREQF 380
Cdd:cd04962  286 ALEAMACGVPVVSSNAGGIPEVVKhgeTGFLSDVGDVDAMAKSALSILEDDELYNRMGRAARKRAAERFD--PERIVPQY 363


                 ....*.
gi 874269245 381 FEYLKK 386
Cdd:cd04962  364 EAYYRR 369
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 111-378 4.71e-16

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 78.86  E-value: 4.71e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 111 YLASQICHKMAIPYgMEVIGDPYEVFAPGVLKHPL--RPVLRHLFtkyqKEMVYQASSVIYVTK--EALQKRYPVR---E 183
Cdd:cd03817   98 KLGLRIARKLKIPI-VHTYHTMYEDYLHYIPKGKLlvKAVVRKLV----RRFYNHTDAVIAPSEkiKDTLREYGVKgpiE 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 184 SVFTTYASDVFVSEVSGKERT--LISSHPIRLISVGSLDQMyKSPEIALQVVHKLvNKGINVHLTWLGKGVFMEDMLKLS 261
Cdd:cd03817  173 VIPNGIDLDKFEKPLNTEERRklGLPPDEPILLYVGRLAKE-KNIDFLLRAFAEL-KKEPNIKLVIVGDGPEREELKELA 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 262 QELNIQDKVYFLGAVSAMEVKRQLDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELI---STECLVEVGAid 338
Cdd:cd03817  251 RELGLADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASELVedgENGFLFEPND-- 328

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 874269245 339 evcdiietmiEKTSFYQDKSKENLDRSKEYLNDFLERKRE 378
Cdd:cd03817  329 ----------ETLAEKLLHLRENLELLRKLSKNAEISARE 358
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 172-370 2.70e-14

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 73.65  E-value: 2.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 172 KEALQKRYPvresvftTYASDVFVSEVSGKERTLISSHP----IRLISVGSLdqmykspeIALQVVHKLVN--------- 238
Cdd:cd04946  189 KDYLQKCYP-------AYKEKIFVSRLGVSDKEQYSKVKkegdLRLVSCSSI--------VPVKRIDLIIEtlnslcvah 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 239 KGINVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSAMEVKRQLDQS--DIFILLSKTEGLPRAMVEAMSRGLPCIG 316
Cdd:cd04946  254 PSICISWTHIGGGPLKERLEKLAENKLENVKVNFTGEVSNKEVKQLYKENdvDVFVNVSESEGIPVSIMEAISFGIPVIA 333

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 874269245 317 TKVGGIPELISTEC----LVEVGAIDEVCDIIETMIEKTSFYQDKSKENLDRSKEYLN 370
Cdd:cd04946  334 TNVGGTREIVENETngllLDKDPTPNEIVSSIMKFYLDGGDYKTMKISARECWEERFN 391
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 285-386 1.40e-13

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 66.94  E-value: 1.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 285 LDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELIS---TECLVEVGAIDEVCDIIETMIEKTSFYQDKSKEN 361
Cdd:COG0438   18 LAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEdgeTGLLVPPGDPEALAEAILRLLEDPELRRRLGEAA 97

                         90       100
                 ....*....|....*....|....*
gi 874269245 362 LDRSKEYLNdfLERKREQFFEYLKK 386
Cdd:COG0438   98 RERAEERFS--WEAIAERLLALYEE 120
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 113-376 8.98e-13

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 68.93  E-value: 8.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 113 ASQICHKMAIPYGMEVIG--DPYEVfapgVLKHPLRPVLRHLFtkyQKEMVYQASSVIYVTKEALQKRYPVresvftTYA 190
Cdd:cd03821  107 ACKLARRRGIPYVVSPHGmlDPWAL----QQKHWKKRIALHLI---ERRNLNNAALVHFTSEQEADELRRF------GLE 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 191 SDVFVSE--VSGKER----TLISSHPIR-----LISVGSLDQMyKSPEIALQVVHKLVNKGINVHLTWLGKG-----VFM 254
Cdd:cd03821  174 PPIAVIPngVDIPEFdpglRDRRKHNGLedrriILFLGRIHPK-KGLDLLIRAARKLAEQGRDWHLVIAGPDdgaypAFL 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 255 EDMlklsQELNIQDKVYFLGAVSAMEVKRQLDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELISTECLVEV 334
Cdd:cd03821  253 QLQ----SSLGLGDRVTFTGPLYGEAKWALYASADLFVLPSYSENFGNVVAEALACGLPVVITDKCGLSELVEAGCGVVV 328

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 874269245 335 gaIDEVCDIIETMIEKTSFYQDKSK--ENLDRSKEYLNDFLERK 376
Cdd:cd03821  329 --DPNVSSLAEALAEALRDPADRKRlgEMARRARQVEENFSWEA 370
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 66-368 3.04e-12

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 67.26  E-value: 3.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245  66 IKEIQPFDNPFSFYRHKGKIKKQ---LIQYLQNQKEAVVIIRGGGALCYLASqicHKMAIPYGMEVIGDPYEVFAPGVLK 142
Cdd:cd03820   53 IKIKNLGDRKYSHFKLLLKYFKKvrrLRKYLKNNKPDVVISFRTSLLTFLAL---IGLKSKLIVWEHNNYEAYNKGLRRL 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 143 hplrpVLRHLFTKYqkemvyqASSVIYVTKEALQKRYPV-RESVFTTYAsdvFVSEVSGKERTLISSHpiRLISVGSLDQ 221
Cdd:cd03820  130 -----LLRRLLYKR-------ADKIVVLTEADKLKKYKQpNSNVVVIPN---PLSFPSEEPSTNLKSK--RILAVGRLTY 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 222 mYKSPEIALQVVHKLVNKginvHLTW----LGKGVFMEDMLKLSQELNIQDKVYFLGAVSAMEVKrqLDQSDIFILLSKT 297
Cdd:cd03820  193 -QKGFDLLIEAWALIAKK----HPDWklriYGDGPEREELEKLIDKLGLEDRVKLLGPTKNIAEE--YANSSIFVLSSRY 265

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 874269245 298 EGLPRAMVEAMSRGLPCIGTK-VGGIPELISTEC---LVEVGAIDEVCDIIETMIEKTSFYQDKSKENLDRSKEY 368
Cdd:cd03820  266 EGFPMVLLEAMAYGLPIISFDcPTGPSEIIEDGEnglLVPNGDVDALAEALLRLMEDEELRKKMGKNARKNAERF 340
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 65-368 6.13e-12

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 66.23  E-value: 6.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245  65 VIKEIQPFDNPFSF--YRHKGKIKKQLIQYLQNQKEAVVIIRGGGALCYLA-----SQICHKMAIPYGMEVIGDPYEVFA 137
Cdd:cd03809   23 LLKALAKNDPDESVlaVPPLPGELLRLLREYPELSLGVIKIKLWRELALLRwlqilLPKKDKPDLLHSPHNTAPLLLKGC 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 138 PGV--------LKHPL--RPVLRHLFTKYQKEMVYQASSVIYV---TKEALQKRYPVRESVFTTY--ASDVFVSEVSGKE 202
Cdd:cd03809  103 PQVvtihdlipLRYPEffPKRFRLYYRLLLPISLRRADAIITVseaTRDDIIKFYGVPPEKIVVIplGVDPSFFPPESAA 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 203 RtLISSHPIR---LISVGSLDqMYKSPEIALQVVHKLVNKGINVHLTWLG-KGVFMEDMLKLSQELNIQDKVYFLGAVSA 278
Cdd:cd03809  183 V-LIAKYLLPepyFLYVGTLE-PRKNHERLLKAFALLKKQGGDLKLVIVGgKGWEDEELLDLVKKLGLGGRVRFLGYVSD 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 279 MEVKRQLDQSDIFILLSKTE--GLPraMVEAMSRGLPCIGTKVGGIPELIS-TECLVEVGAIDEVCDIIETMIEKTSFYQ 355
Cdd:cd03809  261 EDLPALYRGARAFVFPSLYEgfGLP--VLEAMACGTPVIASNISVLPEVAGdAALYFDPLDPESIADAILRLLEDPSLRE 338

                        330
                 ....*....|...
gi 874269245 356 DKSKENLDRSKEY 368
Cdd:cd03809  339 ELIRKGLERAKKF 351
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 224-349 1.25e-11

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 65.45  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 224 KSPEIALQVVHKLvNKGINVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSamEVKRQLDQSDIFILLSKTEGLPRA 303
Cdd:cd03819  195 KGWLLLVDAAAEL-KDEPDFRLLVAGDGPERDEIRRLVERLGLRDRVTFTGFRE--DVPAALAASDVVVLPSLHEEFGRV 271

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 874269245 304 MVEAMSRGLPCIGTKVGGIPELISTEC---LVEVGAIDEVCDIIETMIE 349
Cdd:cd03819  272 ALEAMACGTPVVATDVGGAREIVVHGRtglLVPPGDAEALADAIRAAKL 320
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 260-326 2.16e-11

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 65.05  E-value: 2.16e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 874269245 260 LSQELNIQDKVYFLGAVSAMEVKRQLDqsdIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELI 326
Cdd:cd03813  346 LVASLGLENKVKFLGFQNIKEYYPKLG---LLVLTSISEGQPLVILEAMASGVPVVATDVGSCRELI 409
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 224-348 2.36e-11

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 64.78  E-value: 2.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 224 KSPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKLSQELniqDKVYFLGAVSAMEVKRQLDQSDIFILLSKT------ 297
Cdd:cd05844  202 KGCDVLIEAFRRLAARHPTARLVIAGDGPLRPALQALAAAL---GRVRFLGALPHAEVQDWMRRAEIFCLPSVTaasgds 278

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 874269245 298 EGLPRAMVEAMSRGLPCIGTKVGGIPELI---STECLVEVGAIDEVCDIIETMI 348
Cdd:cd05844  279 EGLGIVLLEAAACGVPVVSSRHGGIPEAIldgETGFLVPEGDVDALADALQALL 332
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 220-325 7.89e-11

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 63.03  E-value: 7.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 220 DQMYKSPEIALQVVHKLV-NKGI---------------NVHLTWLGKG---VFMEDMLklsQELNIQDKVYFLGAVSAME 280
Cdd:cd03796  186 PSKPDPNKITIVVISRLVyRKGIdllvgiiprickkhpNVRFIIGGDGpkrIELEEMR---EKYQLQDRVELLGAVPHEE 262

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 874269245 281 VKRQLDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPEL 325
Cdd:cd03796  263 VRDVLVQGHIFLNTSLTEAFCIAIVEAASCGLLVVSTRVGGIPEV 307
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 153-368 3.33e-10

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 60.78  E-value: 3.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 153 FTKYQKEMVYQASSVIYVT---KEALQKRYPVRESVFTTyasDVFVSEVSGKERTLISSHPIRLISVGSLDQMyKSPEIA 229
Cdd:cd04949  103 FYKYVFENLNKYDAIIVSTeqqKQDLSERFNKYPPIFTI---PVGYVDQLDTAESNHERKSNKIITISRLAPE-KQLDHL 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 230 LQVVHKLVNKGINVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSamEVKRQLDQSDIFILLSKTEGLPRAMVEAMS 309
Cdd:cd04949  179 IEAVAKAVKKVPEITLDIYGYGEEREKLKKLIEELHLEDNVFLKGYHS--NLDQEYQDAYLSLLTSQMEGFGLTLMEAIG 256

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 874269245 310 RGLPCIGTKVG-GIPELIS---TECLVEVGAIDEVCDIIETMIEKTSFYQDKSKENLDRSKEY 368
Cdd:cd04949  257 HGLPVVSYDVKyGPSELIEdgeNGYLIEKNNIDALADKIIELLNDPEKLQQFSEESYKIAEKY 319
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
242-375 1.02e-09

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 59.72  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 242 NVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSAM--EVKRQLDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKV 319
Cdd:PRK09922 210 EWQLHIIGDGSDFEKCKAYSRELGIEQRIIWHGWQSQPweVVQQKIKNVSALLLTSKFEGFPMTLLEAMSYGIPCISSDC 289

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 320 GGIPELISTEC----LVEVGAIDEVCDIIETMIEKTSFYQDKSKENlDRSKEYLNDFLER 375
Cdd:PRK09922 290 MSGPRDIIKPGlngeLYTPGNIDEFVGKLNKVISGEVKYQHDAIPN-SIERFYEVLYFKN 348
PRK15179 PRK15179
Vi polysaccharide biosynthesis protein TviE; Provisional
 224-333 2.75e-09

Vi polysaccharide biosynthesis protein TviE; Provisional


Pssm-ID: 185101 [Multi-domain]  Cd Length: 694  Bit Score: 58.89  E-value: 2.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 224 KSPEIALQVVHKLVNKGINVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAvsAMEVKRQLDQSDIFILLSKTEGLPRA 303
Cdd:PRK15179 530 KRPFLWVEAAQRFAASHPKVRFIMVGGGPLLESVREFAQRLGMGERILFTGL--SRRVGYWLTQFNAFLLLSRFEGLPNV 607

                         90       100       110
                 ....*....|....*....|....*....|
gi 874269245 304 MVEAMSRGLPCIGTKVGGipeliSTECLVE 333
Cdd:PRK15179 608 LIEAQFSGVPVVTTLAGG-----AGEAVQE 632
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 201-385 1.11e-08

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 56.18  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 201 KERTLISSHPIRLISVGSLDQmYKSPEIALQVVHKLVNKGInvHLTWLGKGvfmedmlKLSQELNIQ--DKVYFLGAVSA 278
Cdd:cd03823  182 PPRRRPGTERLRFGYIGRLTE-EKGIDLLVEAFKRLPREDI--ELVIAGHG-------PLSDERQIEggRRIAFLGRVPT 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 279 MEVKRQLDQSDIFILLSK-TEGLPRAMVEAMSRGLPCIGTKVGGIPELISTEC---LVEVGAIDEVCDIIETMIEktsfy 354
Cdd:cd03823  252 DDIKDFYEKIDVLVVPSIwPEPFGLVVREAIAAGLPVIASDLGGIAELIQPGVnglLFAPGDAEDLAAAMRRLLT----- 326

                        170       180       190
                 ....*....|....*....|....*....|.
gi 874269245 355 qdksKENLDRSKEYLNDFLERKREQFFEYLK 385
Cdd:cd03823  327 ----DPALLERLRAGAEPPRSTESQAEEYLK 353
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 213-327 1.79e-08

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 55.53  E-value: 1.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 213 LISVGSLDQMYKSPEIaLQVVHKLVNKGINVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGAVSamEVKRQLDQSDIFI 292
Cdd:cd04951  191 ILNVGRLTEAKDYPNL-LLAISELILSKNDFKLLIAGDGPLRNELERLICNLNLVDRVILLGQIS--NISEYYNAADLFV 267

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 874269245 293 LLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELIS 327
Cdd:cd04951  268 LSSEWEGFGLVVAEAMACERPVVATDAGGVAEVVG 302
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 215-326 2.43e-08

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 55.50  E-value: 2.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245  215 SVGSLdQMYKSPEIALQVVHKLVNKG----INVHLTWLGKGVFMEDMLKLSQELNIQDKVYFLGavSAMEVKRQLDQSDI 290
Cdd:TIGR03088 199 TVGRL-QAVKDQPTLVRAFALLVRQLpegaERLRLVIVGDGPARGACEQMVRAAGLAHLVWLPG--ERDDVPALMQALDL 275

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 874269245  291 FILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELI 326
Cdd:TIGR03088 276 FVLPSLAEGISNTILEAMASGLPVIATAVGGNPELV 311
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 242-355 5.19e-08

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 54.72  E-value: 5.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 242 NVHLTWLGKGVFMEDMLKLSQELNiqdkVYFLGAVSAMEVKRQLDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGG 321
Cdd:PLN02871 290 GARLAFVGDGPYREELEKMFAGTP----TVFTGMLQGDELSQAYASGDVFVMPSESETLGFVVLEAMASGVPVVAARAGG 365

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 874269245 322 IPELIS------TECLVEVGAIDEVCDIIETMIEKTSFYQ 355
Cdd:PLN02871 366 IPDIIPpdqegkTGFLYTPGDVDDCVEKLETLLADPELRE 405
PRK15490 PRK15490
Vi polysaccharide biosynthesis glycosyltransferase TviE;
248-333 1.00e-07

Vi polysaccharide biosynthesis glycosyltransferase TviE;


Pssm-ID: 185387 [Multi-domain]  Cd Length: 578  Bit Score: 53.94  E-value: 1.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 248 LGKGVFMEDMLKLSQELNIQDKVYFLGAvsAMEVKRQLDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGipeliS 327
Cdd:PRK15490 435 VGDGDLRAEAQKRAEQLGILERILFVGA--SRDVGYWLQKMNVFILFSRYEGLPNVLIEAQMVGVPVISTPAGG-----S 507


                 ....*.
gi 874269245 328 TECLVE 333
Cdd:PRK15490 508 AECFIE 513
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 239-321 6.36e-07

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 50.74  E-value: 6.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 239 KGINVHLTWLGKGVFMEDMLKLSqELNIQDKVYFLGAVSAMEVKRQLDQSDIFILLS--KTEGLPRAMVEAMSRGLPCIG 316
Cdd:cd03795  214 QYLNYPIVIGGEGPLKPDLEAQI-ELNLLDNVKFLGRVDDEEKVIYLHLCDVFVFPSvlRSEAFGIVLLEAMMCGKPVIS 292


                 ....*
gi 874269245 317 TKVGG 321
Cdd:cd03795  293 TNIGT 297
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 289-354 2.60e-06

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 48.87  E-value: 2.60e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 874269245 289 DIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELI---STECLVEVGAIDEVCDIIETMIEKTSFY 354
Cdd:cd03825  265 DLFVHPSLADNLPNTLLEAMACGTPVVAFDTGGSPEIVqhgVTGYLVPPGDVQALAEAIEWLLANPKER 333
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 203-368 3.94e-06

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 48.39  E-value: 3.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 203 RTLISSHPIRLISVGSLDQMyKSPEIALQVVHKLVNKGINVHLTWLGKGVFMED------MLKLSQELNIQDKVYFLGAV 276
Cdd:cd03800  213 RLLLPPDKPVVLALGRLDPR-KGIDTLVRAFAQLPELRELANLVLVGGPSDDPLsmdreeLAELAEELGLIDRVRFPGRV 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 277 SAMEVKRQLDQSDIFILLSKTE--GLprAMVEAMSRGLPCIGTKVGGIPELIS---TECLVEVGAIDEVCDIIETMIEKT 351
Cdd:cd03800  292 SRDDLPELYRAADVFVVPSLYEpfGL--TAIEAMACGTPVVATAVGGLQDIVRdgrTGLLVDPHDPEALAAALRRLLDDP 369

                        170
                 ....*....|....*..
gi 874269245 352 SFYQDKSKENLDRSKEY 368
Cdd:cd03800  370 ALWQRLSRAGLERARAH 386
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 270-349 6.75e-06

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 47.67  E-value: 6.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 270 VYFLGAVSAMEVKRQLDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELIS---TECLVEVGAIDEVCDIIET 346
Cdd:cd03814  250 VIFTGFLTGEELARAYASADVFVFPSRTETFGLVVLEAMASGLPVVAADAGGPRDIVRpggTGALVEPGDAAAFAAALRA 329


                 ...
gi 874269245 347 MIE 349
Cdd:cd03814  330 LLE 332
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 224-326 8.29e-05

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 44.20  E-value: 8.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 224 KSPEIALQVVHKLvnkgiNVHLTWLGKgVFMEDMLKLSQELNIQDKVYFLGAVSAMEVKRQLDQSD---IFILLSKTEGL 300
Cdd:cd03802  182 KGLEDAIRVARRA-----GLPLKIAGK-VRDEDYFYYLQEPLPGPRIEFIGEVGHDEKQELLGGARallFPINWDEPFGL 255

                         90       100
                 ....*....|....*....|....*.
gi 874269245 301 prAMVEAMSRGLPCIGTKVGGIPELI 326
Cdd:cd03802  256 --VMIEAMACGTPVIAYRRGGLPEVI 279
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 260-326 1.15e-04

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 44.15  E-value: 1.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 874269245 260 LSQELNIQDKVYFLGAVSAMEVkrqLDQSDIFILLSKTEGLPRAMVEAMSRGLPCIGTKVGGIPELI 326
Cdd:NF038011 359 LVASLGLQDKVKFLGFQKIDDL---LPQVGLMVLSSISEALPLVVLEAFAAGVPVVTTDVGSCRQLI 422
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 109-349 3.39e-04

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 42.33  E-value: 3.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 109 LCYLASQICHKMAIPYGMEVIgDPY--EVFAPGVLKhplRPVLRHLFTKYQKEMVYQASSVIYVT---KEALQKRYPVRE 183
Cdd:cd03794  111 LGLAALLLKKLRGAPFILDVR-DLWpeSLIALGVLK---KGSLLKLLKKLERKLYRLADAIIVLSpglKEYLLRKGVPKE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 184 --SVFTTYASDVFVSEVSGKER--TLISSHPIRLISVGSldqMYKS--PEIALQVVhKLVNKGINVHLTWLGKGVFMEDM 257
Cdd:cd03794  187 kiIVIPNWADLEEFKPPPKDELrkKLGLDDKFVVVYAGN---IGKAqgLETLLEAA-ERLKRRPDIRFLFVGDGDEKERL 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 874269245 258 LKLSQELNIQDkVYFLGAVSAMEVKRQLDQSDI-FILLSKTE----GLPRAMVEAMSRGLPCIGTKVGGIPELI---STE 329
Cdd:cd03794  263 KELAKARGLDN-VTFLGRVPKEEVPELLSAADVgLVPLKDNPanrgSSPSKLFEYMAAGKPILASDDGGSDLAVeinGCG 341

                        250       260
                 ....*....|....*....|
gi 874269245 330 CLVEVGAIDEVCDIIETMIE 349
Cdd:cd03794  342 LVVEPGDPEALADAILELLD 361
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH