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Conserved domains on  [gi|872154015|emb|CRN61936|]
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putative ester cyclase [Pseudomonas aeruginosa]

Protein Classification

nuclear transport factor 2 family protein( domain architecture ID 10020202)

nuclear transport factor 2 (NTF2) family protein with a SnoaL-like polyketide cyclase domain

CATH:  3.10.450.50
SCOP:  3000472|4001306

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIGR02096 TIGR02096
conserved hypothetical protein, steroid delta-isomerase-related; This family of proteins about ...
 7-135 4.52e-52

conserved hypothetical protein, steroid delta-isomerase-related; This family of proteins about 135 amino acids in length largely restricted to the Proteobacteria. This family and a delta5-3-ketosteroid isomerase from Pseudomonas testosteroni appear homologous, especially toward their respective N-termini. Members, therefore, probably are enzymes.


:

Pssm-ID: 273970  Cd Length: 129  Bit Score: 161.39  E-value: 4.52e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872154015    7 KRLARHHIELsWNKGRMALVEQLHSKDFLYKSSFIGRPLDT-AGYIRLLQDIRTAMPDLEVVVEDCIGEER-KVFTWSTL 84
Cdd:TIGR02096   1 TELAQHWIEA-FNRGDMDAVLALLAEDVLYDDNQGGRVLGGkAQLARFLAPYRTAFPDLLVDVVVCRNDEGvRVAAEWTV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 872154015   85 IGTIVRPTLGYPASDKVLSISAMGFWVFNpQGQLQELCTMFDMESFRAQLG 135
Cdd:TIGR02096  80 HGTYRTAFLGLPASGKTYSIRGVTFFVFD-DGKIKRETTYYNLATFLRQLG 129
 
Name Accession Description Interval E-value
TIGR02096 TIGR02096
conserved hypothetical protein, steroid delta-isomerase-related; This family of proteins about ...
 7-135 4.52e-52

conserved hypothetical protein, steroid delta-isomerase-related; This family of proteins about 135 amino acids in length largely restricted to the Proteobacteria. This family and a delta5-3-ketosteroid isomerase from Pseudomonas testosteroni appear homologous, especially toward their respective N-termini. Members, therefore, probably are enzymes.


Pssm-ID: 273970  Cd Length: 129  Bit Score: 161.39  E-value: 4.52e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872154015    7 KRLARHHIELsWNKGRMALVEQLHSKDFLYKSSFIGRPLDT-AGYIRLLQDIRTAMPDLEVVVEDCIGEER-KVFTWSTL 84
Cdd:TIGR02096   1 TELAQHWIEA-FNRGDMDAVLALLAEDVLYDDNQGGRVLGGkAQLARFLAPYRTAFPDLLVDVVVCRNDEGvRVAAEWTV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 872154015   85 IGTIVRPTLGYPASDKVLSISAMGFWVFNpQGQLQELCTMFDMESFRAQLG 135
Cdd:TIGR02096  80 HGTYRTAFLGLPASGKTYSIRGVTFFVFD-DGKIKRETTYYNLATFLRQLG 129
COG5485 COG5485
Predicted ester cyclase [General function prediction only];
9-136 4.46e-31

Predicted ester cyclase [General function prediction only];


Pssm-ID: 444236 [Multi-domain]  Cd Length: 130  Bit Score: 108.02  E-value: 4.46e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872154015   9 LARHHIELSWNKGRMALVEQLHSKDFLYKSSFIGRPLDTAGYIRLLQDIRTAMPDLEVVVEDCIGEERKVFTWSTLIGTI 88
Cdd:COG5485    1 LVRRFFEEAWNEGDLDALDELVAPDFVYHGPLPGEPRGPEGFRAFLRGLRAAFPDLRFEIEDLIAEGDRVAVRWTFTGTH 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 872154015  89 VRPTLGYPASDKVLSISAMGFWVFNpQGQLQELCTMFDMESFRAQLGL 136
Cdd:COG5485   81 TGEFLGIPPTGKRVEFRGIDIYRFE-DGKIVEEWVVEDLLGLLQQLGA 127
SnoaL pfam07366
SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in ...
 7-121 9.41e-12

SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation.


Pssm-ID: 399975  Cd Length: 126  Bit Score: 58.47  E-value: 9.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872154015    7 KRLARHHIELsWNKGRMALVEQLHSKDFLYKSSFIGRPLDTAGYIRLLQDIRTAMPDLEVVVEDCIGEERKVFTWSTLIG 86
Cdd:pfam07366   1 ALVLRFYDEV-WNTGDLDALDEFVAEDVVDHNPPPGVARGLDGFRAFAEMLFRAFPDLRFEVEDLVAEGDKVAARLTFTG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 872154015   87 TIVRPTLGYPASDKVLSISAMGF------------WVFNPQGQLQEL 121
Cdd:pfam07366  80 THTGEFLGIPPTGRKVRFRGIDLyrfedgkivehwDVIDLLGLLRQL 126
 
Name Accession Description Interval E-value
TIGR02096 TIGR02096
conserved hypothetical protein, steroid delta-isomerase-related; This family of proteins about ...
 7-135 4.52e-52

conserved hypothetical protein, steroid delta-isomerase-related; This family of proteins about 135 amino acids in length largely restricted to the Proteobacteria. This family and a delta5-3-ketosteroid isomerase from Pseudomonas testosteroni appear homologous, especially toward their respective N-termini. Members, therefore, probably are enzymes.


Pssm-ID: 273970  Cd Length: 129  Bit Score: 161.39  E-value: 4.52e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872154015    7 KRLARHHIELsWNKGRMALVEQLHSKDFLYKSSFIGRPLDT-AGYIRLLQDIRTAMPDLEVVVEDCIGEER-KVFTWSTL 84
Cdd:TIGR02096   1 TELAQHWIEA-FNRGDMDAVLALLAEDVLYDDNQGGRVLGGkAQLARFLAPYRTAFPDLLVDVVVCRNDEGvRVAAEWTV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 872154015   85 IGTIVRPTLGYPASDKVLSISAMGFWVFNpQGQLQELCTMFDMESFRAQLG 135
Cdd:TIGR02096  80 HGTYRTAFLGLPASGKTYSIRGVTFFVFD-DGKIKRETTYYNLATFLRQLG 129
COG5485 COG5485
Predicted ester cyclase [General function prediction only];
9-136 4.46e-31

Predicted ester cyclase [General function prediction only];


Pssm-ID: 444236 [Multi-domain]  Cd Length: 130  Bit Score: 108.02  E-value: 4.46e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872154015   9 LARHHIELSWNKGRMALVEQLHSKDFLYKSSFIGRPLDTAGYIRLLQDIRTAMPDLEVVVEDCIGEERKVFTWSTLIGTI 88
Cdd:COG5485    1 LVRRFFEEAWNEGDLDALDELVAPDFVYHGPLPGEPRGPEGFRAFLRGLRAAFPDLRFEIEDLIAEGDRVAVRWTFTGTH 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 872154015  89 VRPTLGYPASDKVLSISAMGFWVFNpQGQLQELCTMFDMESFRAQLGL 136
Cdd:COG5485   81 TGEFLGIPPTGKRVEFRGIDIYRFE-DGKIVEEWVVEDLLGLLQQLGA 127
SnoaL pfam07366
SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in ...
 7-121 9.41e-12

SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation.


Pssm-ID: 399975  Cd Length: 126  Bit Score: 58.47  E-value: 9.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872154015    7 KRLARHHIELsWNKGRMALVEQLHSKDFLYKSSFIGRPLDTAGYIRLLQDIRTAMPDLEVVVEDCIGEERKVFTWSTLIG 86
Cdd:pfam07366   1 ALVLRFYDEV-WNTGDLDALDEFVAEDVVDHNPPPGVARGLDGFRAFAEMLFRAFPDLRFEVEDLVAEGDKVAARLTFTG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 872154015   87 TIVRPTLGYPASDKVLSISAMGF------------WVFNPQGQLQEL 121
Cdd:pfam07366  80 THTGEFLGIPPTGRKVRFRGIDLyrfedgkivehwDVIDLLGLLRQL 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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