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Conserved domains on  [gi|86277544|gb|ABC88271|]
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envelope glycoprotein [Human immunodeficiency virus 1]

Protein Classification

envelope glycoprotein gp160( domain architecture ID 10255485)

envelope glycoprotein gp160 oligomerizes in the host endoplasmic reticulum into predominantly trimers, transits in the host Golgi, where glycosylation is completed, and then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41

Gene Ontology:  GO:0016020|GO:0019031
PubMed:  9641677

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GP120 super family cl02884
Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss: ...
 32-497 0e+00

Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss:P01730 and a chemokine receptor on the cell surface.


The actual alignment was detected with superfamily member pfam00516:

Pssm-ID: 278917  Cd Length: 525  Bit Score: 637.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544    32 LWVTVYYGVPVWKEATTTLFCASDAKSYEKEVHNVWATHACVPTDPDPQEVVLGNVTENFNMWKNDMVEQMHTDIISVWD 111
Cdd:pfam00516   1 LWVTVFYGIPAWKEASIPLFCASDAKAYDTENHDTWATHACLPDDDDPQEIILVNVTEAFDAWKNDMTEQAHEDIIHLFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   112 QSLKPCVKLTPLCVTLHCINV--NTTTNSTQRSSTLKE-----------ETGA--------------IQNCSFNMTTEVR 164
Cdd:pfam00516  81 QSIKPCVKLTPLCVALKCSDLkgDTNTPNPRTSSSTTSrpnssaariimEKGNcienntcaglgyeeIKNCEFNIKTGIE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   165 DKRLQVHALFYKLDIVAINDSKNE--YRLINCNTSTIKQACPKVSWDPIPIHYCAPAGYAILKCRDKKFNGTGP-CNNVS 241
Cdd:pfam00516 161 GDKKKEYADFWKLDDIPCDNDTAGtcYKLRHCNTSIIKEACDKHSFDAIPFHYCAPAGFAILKCNDKNFNGFEPkCTKVS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   242 TVQCTHGIKPVVSTQLLLNGSLAKGDIVI----RSQNITDNAKTIIVHLNE--SVWINCTRPNNNTRKSIHI--GPGQAF 313
Cdd:pfam00516 241 AAQCTHGIEPQTSTQFGFNGSLAEEETVIywhgRSVNFTDNAKTIIVQLNKyyNLEINCKRPGNKTRKPIRImrGPGRAF 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   314 YATGEIIG-DIRKAHCNVSGTQWNTTLGRVKEKL------KVYFQNKTINFNS-SSGGDLEITMHSFNCRGEFFYCNTSG 385
Cdd:pfam00516 321 VFHGKIGNmRPRQAHCNFGRAKWNEALKEIAQKLrehpryKGFGDNGKIIFTKpGAGGDPEIAFHSFNCGGEFFYCNMTQ 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   386 LFQF------------NDTDSNDTIILPCRIKQIVNMWQEVGRAMYAAPIAGNITCNSNITGLLLTRDGGQDNGTNDIeT 453
Cdd:pfam00516 401 FFNStwfnstwstedkNNTEGNDTITLPCHIKQIINMWHKVGKAMYAPPIEGEIACESNITGIIANIDGDKNNNESEI-T 479

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 86277544   454 FRPGGGNMKDNWRSELYKYKVVEINPLGIAPSRAKR--QVVQREKR 497
Cdd:pfam00516 480 FRPGGADMADLWRLELGDYKLIEIEPIGFAPTDAKRysRTPQREKR 525
HIV-1-like_HR1-HR2 cd09909
heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human ...
 525-651 1.33e-47

heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human immunodeficiency virus (HIV-1), and related domains; This domain family spans both heptad repeats of the glycoprotein (gp)/transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including human, simian, and feline immunodeficiency viruses (HIV, SIV, and FIV), bovine immunodeficiency-like virus (BIV), equine infectious anaemia virus (EIAV), and Jaagsiekte sheep retrovirus (JSRV), mouse mammary tumour virus (MMTV) and various ERVs including sheep enJSRV-26, and human ERVs (HERVs): HERV-K_c1q23.3 and HERV-K_c12q14.1. This domain belongs to a larger superfamily containing the HR1-HR2 domain of ERVs and infectious retroviruses, including Ebola virus, and Rous sarcoma virus. Proteins in this family lack the canonical CSK17-like immunosuppressive sequence, and the intrasubunit disulfide bond-forming CX6C motif found in linker region between HR1 and HR2 in the Ebola_RSV-like_HR1-HR2 family. N-terminal to the HR1-HR2 region is a fusion peptide (FP), and C-terminal is a membrane-spanning region (MSR). Viral infection involves the formation of a trimer-of-hairpins structure (three HR1 helices, buttressed by three HR2 helices lying in antiparallel orientation). In this structure, the FP (inserted in the host cell membrane) and MSR (inserted in the viral membrane) are in close proximity. ERVs are likely to originate from ancient germ-line infections by active retroviruses. Some modern ERVs, those that integrated into the host genome post-speciation, have a currently active exogenous counterpart, such as JSRV. Some ERVs play specific roles in the host, including placental development, protection of the host from infection by related pathogenic and exogenous retroviruses, and genome plasticity. Included in this subgroup are ERVs from domestic sheep that are related to JSRV, the agent of transmissible lung cancer in sheep, for example enJSRV-26 that retains an intact genome. These endogenous JSRVs protect the sheep against JSRV infection and are required for sheep placental development. HERV-K_c12q14.1 is potentially a complete envelope protein; however, it does not appear to be fusogenic.


:

Pssm-ID: 197369  Cd Length: 128  Bit Score: 165.26  E-value: 1.33e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544 525 VQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLRDQQLLGLWGCSGKL-ICTTNVPWNSSWSNK 603
Cdd:cd09909   1 VQARQLLVTRVQQQQSLIDAIEKLEHLLNLLYWVVKQLGARVQALEFRLKIQCHLNLWGCVTKQpYCHTDVPWNRSWNHL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 86277544 604 SHNEIWGNMTWMEWEKEIDNYSDVIYRLIEESQNQQEKNEKDLLALDS 651
Cdd:cd09909  81 QGNDNWISLTWQEWENKIDDLEEKILNLLEEAQNQLEKLADGLLSLDP 128
 
Name Accession Description Interval E-value
GP120 pfam00516
Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss: ...
 32-497 0e+00

Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss:P01730 and a chemokine receptor on the cell surface.


Pssm-ID: 278917  Cd Length: 525  Bit Score: 637.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544    32 LWVTVYYGVPVWKEATTTLFCASDAKSYEKEVHNVWATHACVPTDPDPQEVVLGNVTENFNMWKNDMVEQMHTDIISVWD 111
Cdd:pfam00516   1 LWVTVFYGIPAWKEASIPLFCASDAKAYDTENHDTWATHACLPDDDDPQEIILVNVTEAFDAWKNDMTEQAHEDIIHLFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   112 QSLKPCVKLTPLCVTLHCINV--NTTTNSTQRSSTLKE-----------ETGA--------------IQNCSFNMTTEVR 164
Cdd:pfam00516  81 QSIKPCVKLTPLCVALKCSDLkgDTNTPNPRTSSSTTSrpnssaariimEKGNcienntcaglgyeeIKNCEFNIKTGIE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   165 DKRLQVHALFYKLDIVAINDSKNE--YRLINCNTSTIKQACPKVSWDPIPIHYCAPAGYAILKCRDKKFNGTGP-CNNVS 241
Cdd:pfam00516 161 GDKKKEYADFWKLDDIPCDNDTAGtcYKLRHCNTSIIKEACDKHSFDAIPFHYCAPAGFAILKCNDKNFNGFEPkCTKVS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   242 TVQCTHGIKPVVSTQLLLNGSLAKGDIVI----RSQNITDNAKTIIVHLNE--SVWINCTRPNNNTRKSIHI--GPGQAF 313
Cdd:pfam00516 241 AAQCTHGIEPQTSTQFGFNGSLAEEETVIywhgRSVNFTDNAKTIIVQLNKyyNLEINCKRPGNKTRKPIRImrGPGRAF 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   314 YATGEIIG-DIRKAHCNVSGTQWNTTLGRVKEKL------KVYFQNKTINFNS-SSGGDLEITMHSFNCRGEFFYCNTSG 385
Cdd:pfam00516 321 VFHGKIGNmRPRQAHCNFGRAKWNEALKEIAQKLrehpryKGFGDNGKIIFTKpGAGGDPEIAFHSFNCGGEFFYCNMTQ 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   386 LFQF------------NDTDSNDTIILPCRIKQIVNMWQEVGRAMYAAPIAGNITCNSNITGLLLTRDGGQDNGTNDIeT 453
Cdd:pfam00516 401 FFNStwfnstwstedkNNTEGNDTITLPCHIKQIINMWHKVGKAMYAPPIEGEIACESNITGIIANIDGDKNNNESEI-T 479

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 86277544   454 FRPGGGNMKDNWRSELYKYKVVEINPLGIAPSRAKR--QVVQREKR 497
Cdd:pfam00516 480 FRPGGADMADLWRLELGDYKLIEIEPIGFAPTDAKRysRTPQREKR 525
HIV-1-like_HR1-HR2 cd09909
heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human ...
 525-651 1.33e-47

heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human immunodeficiency virus (HIV-1), and related domains; This domain family spans both heptad repeats of the glycoprotein (gp)/transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including human, simian, and feline immunodeficiency viruses (HIV, SIV, and FIV), bovine immunodeficiency-like virus (BIV), equine infectious anaemia virus (EIAV), and Jaagsiekte sheep retrovirus (JSRV), mouse mammary tumour virus (MMTV) and various ERVs including sheep enJSRV-26, and human ERVs (HERVs): HERV-K_c1q23.3 and HERV-K_c12q14.1. This domain belongs to a larger superfamily containing the HR1-HR2 domain of ERVs and infectious retroviruses, including Ebola virus, and Rous sarcoma virus. Proteins in this family lack the canonical CSK17-like immunosuppressive sequence, and the intrasubunit disulfide bond-forming CX6C motif found in linker region between HR1 and HR2 in the Ebola_RSV-like_HR1-HR2 family. N-terminal to the HR1-HR2 region is a fusion peptide (FP), and C-terminal is a membrane-spanning region (MSR). Viral infection involves the formation of a trimer-of-hairpins structure (three HR1 helices, buttressed by three HR2 helices lying in antiparallel orientation). In this structure, the FP (inserted in the host cell membrane) and MSR (inserted in the viral membrane) are in close proximity. ERVs are likely to originate from ancient germ-line infections by active retroviruses. Some modern ERVs, those that integrated into the host genome post-speciation, have a currently active exogenous counterpart, such as JSRV. Some ERVs play specific roles in the host, including placental development, protection of the host from infection by related pathogenic and exogenous retroviruses, and genome plasticity. Included in this subgroup are ERVs from domestic sheep that are related to JSRV, the agent of transmissible lung cancer in sheep, for example enJSRV-26 that retains an intact genome. These endogenous JSRVs protect the sheep against JSRV infection and are required for sheep placental development. HERV-K_c12q14.1 is potentially a complete envelope protein; however, it does not appear to be fusogenic.


Pssm-ID: 197369  Cd Length: 128  Bit Score: 165.26  E-value: 1.33e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544 525 VQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLRDQQLLGLWGCSGKL-ICTTNVPWNSSWSNK 603
Cdd:cd09909   1 VQARQLLVTRVQQQQSLIDAIEKLEHLLNLLYWVVKQLGARVQALEFRLKIQCHLNLWGCVTKQpYCHTDVPWNRSWNHL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 86277544 604 SHNEIWGNMTWMEWEKEIDNYSDVIYRLIEESQNQQEKNEKDLLALDS 651
Cdd:cd09909  81 QGNDNWISLTWQEWENKIDDLEEKILNLLEEAQNQLEKLADGLLSLDP 128
GP41 pfam00517
Retroviral envelope protein; This family includes envelope protein from a variety of ...
 516-691 5.49e-43

Retroviral envelope protein; This family includes envelope protein from a variety of retroviruses. It includes the GP41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) which mediate membrane fusion during viral entry. The family also includes bovine immunodeficiency virus, feline immunodeficiency virus and Equine infectious anaemia (EIAV). The family also includes the Gp36 protein from mouse mammary tumour virus (MMTV) and human endogenous retroviruses (HERVs).


Pssm-ID: 395415  Cd Length: 197  Bit Score: 154.76  E-value: 5.49e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   516 MGAASMALTVQARQLLSGIvqqQNNLLRAIEAQQHLlqltvwgIKQLQARILAVERY----------LRDQQLLGLWGcS 585
Cdd:pfam00517   1 MAAVSLTLSIQAATLVDGL---QYNVTKVMGTQQDI-------DKKLEARLSALEDVvrvlgeqvqsLKFRMKLQCHA-N 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   586 GKLICTTNVPWNSS----WSNKSHNEIWGNMtwmewekEIDNYSDVIYRLIEESQNQQEKNEKDLLALDSWA-SLWNWFD 660
Cdd:pfam00517  70 YKWICVTKVPYNASdpwdKVKKHLQGIWNNT-------EVSYDLLQLHNLIEDIQNQQEKTLNELDTLDNWAqSLFNWFP 142

                         170       180       190
                  ....*....|....*....|....*....|...
gi 86277544   661 ISN--WLWYirifimIVGGLIGLRIVFTVLSIV 691
Cdd:pfam00517 143 SLNslWRSY------IIAGGVGLRIVLIVLCLA 169
 
Name Accession Description Interval E-value
GP120 pfam00516
Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss: ...
 32-497 0e+00

Envelope glycoprotein GP120; The entry of HIV requires interaction of viral GP120 with Swiss:P01730 and a chemokine receptor on the cell surface.


Pssm-ID: 278917  Cd Length: 525  Bit Score: 637.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544    32 LWVTVYYGVPVWKEATTTLFCASDAKSYEKEVHNVWATHACVPTDPDPQEVVLGNVTENFNMWKNDMVEQMHTDIISVWD 111
Cdd:pfam00516   1 LWVTVFYGIPAWKEASIPLFCASDAKAYDTENHDTWATHACLPDDDDPQEIILVNVTEAFDAWKNDMTEQAHEDIIHLFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   112 QSLKPCVKLTPLCVTLHCINV--NTTTNSTQRSSTLKE-----------ETGA--------------IQNCSFNMTTEVR 164
Cdd:pfam00516  81 QSIKPCVKLTPLCVALKCSDLkgDTNTPNPRTSSSTTSrpnssaariimEKGNcienntcaglgyeeIKNCEFNIKTGIE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   165 DKRLQVHALFYKLDIVAINDSKNE--YRLINCNTSTIKQACPKVSWDPIPIHYCAPAGYAILKCRDKKFNGTGP-CNNVS 241
Cdd:pfam00516 161 GDKKKEYADFWKLDDIPCDNDTAGtcYKLRHCNTSIIKEACDKHSFDAIPFHYCAPAGFAILKCNDKNFNGFEPkCTKVS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   242 TVQCTHGIKPVVSTQLLLNGSLAKGDIVI----RSQNITDNAKTIIVHLNE--SVWINCTRPNNNTRKSIHI--GPGQAF 313
Cdd:pfam00516 241 AAQCTHGIEPQTSTQFGFNGSLAEEETVIywhgRSVNFTDNAKTIIVQLNKyyNLEINCKRPGNKTRKPIRImrGPGRAF 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   314 YATGEIIG-DIRKAHCNVSGTQWNTTLGRVKEKL------KVYFQNKTINFNS-SSGGDLEITMHSFNCRGEFFYCNTSG 385
Cdd:pfam00516 321 VFHGKIGNmRPRQAHCNFGRAKWNEALKEIAQKLrehpryKGFGDNGKIIFTKpGAGGDPEIAFHSFNCGGEFFYCNMTQ 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   386 LFQF------------NDTDSNDTIILPCRIKQIVNMWQEVGRAMYAAPIAGNITCNSNITGLLLTRDGGQDNGTNDIeT 453
Cdd:pfam00516 401 FFNStwfnstwstedkNNTEGNDTITLPCHIKQIINMWHKVGKAMYAPPIEGEIACESNITGIIANIDGDKNNNESEI-T 479

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 86277544   454 FRPGGGNMKDNWRSELYKYKVVEINPLGIAPSRAKR--QVVQREKR 497
Cdd:pfam00516 480 FRPGGADMADLWRLELGDYKLIEIEPIGFAPTDAKRysRTPQREKR 525
HIV-1-like_HR1-HR2 cd09909
heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human ...
 525-651 1.33e-47

heptad repeat 1-heptad repeat 2 region (ectodomain) of the gp41 subunit of human immunodeficiency virus (HIV-1), and related domains; This domain family spans both heptad repeats of the glycoprotein (gp)/transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including human, simian, and feline immunodeficiency viruses (HIV, SIV, and FIV), bovine immunodeficiency-like virus (BIV), equine infectious anaemia virus (EIAV), and Jaagsiekte sheep retrovirus (JSRV), mouse mammary tumour virus (MMTV) and various ERVs including sheep enJSRV-26, and human ERVs (HERVs): HERV-K_c1q23.3 and HERV-K_c12q14.1. This domain belongs to a larger superfamily containing the HR1-HR2 domain of ERVs and infectious retroviruses, including Ebola virus, and Rous sarcoma virus. Proteins in this family lack the canonical CSK17-like immunosuppressive sequence, and the intrasubunit disulfide bond-forming CX6C motif found in linker region between HR1 and HR2 in the Ebola_RSV-like_HR1-HR2 family. N-terminal to the HR1-HR2 region is a fusion peptide (FP), and C-terminal is a membrane-spanning region (MSR). Viral infection involves the formation of a trimer-of-hairpins structure (three HR1 helices, buttressed by three HR2 helices lying in antiparallel orientation). In this structure, the FP (inserted in the host cell membrane) and MSR (inserted in the viral membrane) are in close proximity. ERVs are likely to originate from ancient germ-line infections by active retroviruses. Some modern ERVs, those that integrated into the host genome post-speciation, have a currently active exogenous counterpart, such as JSRV. Some ERVs play specific roles in the host, including placental development, protection of the host from infection by related pathogenic and exogenous retroviruses, and genome plasticity. Included in this subgroup are ERVs from domestic sheep that are related to JSRV, the agent of transmissible lung cancer in sheep, for example enJSRV-26 that retains an intact genome. These endogenous JSRVs protect the sheep against JSRV infection and are required for sheep placental development. HERV-K_c12q14.1 is potentially a complete envelope protein; however, it does not appear to be fusogenic.


Pssm-ID: 197369  Cd Length: 128  Bit Score: 165.26  E-value: 1.33e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544 525 VQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLRDQQLLGLWGCSGKL-ICTTNVPWNSSWSNK 603
Cdd:cd09909   1 VQARQLLVTRVQQQQSLIDAIEKLEHLLNLLYWVVKQLGARVQALEFRLKIQCHLNLWGCVTKQpYCHTDVPWNRSWNHL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 86277544 604 SHNEIWGNMTWMEWEKEIDNYSDVIYRLIEESQNQQEKNEKDLLALDS 651
Cdd:cd09909  81 QGNDNWISLTWQEWENKIDDLEEKILNLLEEAQNQLEKLADGLLSLDP 128
GP41 pfam00517
Retroviral envelope protein; This family includes envelope protein from a variety of ...
 516-691 5.49e-43

Retroviral envelope protein; This family includes envelope protein from a variety of retroviruses. It includes the GP41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) which mediate membrane fusion during viral entry. The family also includes bovine immunodeficiency virus, feline immunodeficiency virus and Equine infectious anaemia (EIAV). The family also includes the Gp36 protein from mouse mammary tumour virus (MMTV) and human endogenous retroviruses (HERVs).


Pssm-ID: 395415  Cd Length: 197  Bit Score: 154.76  E-value: 5.49e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   516 MGAASMALTVQARQLLSGIvqqQNNLLRAIEAQQHLlqltvwgIKQLQARILAVERY----------LRDQQLLGLWGcS 585
Cdd:pfam00517   1 MAAVSLTLSIQAATLVDGL---QYNVTKVMGTQQDI-------DKKLEARLSALEDVvrvlgeqvqsLKFRMKLQCHA-N 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 86277544   586 GKLICTTNVPWNSS----WSNKSHNEIWGNMtwmewekEIDNYSDVIYRLIEESQNQQEKNEKDLLALDSWA-SLWNWFD 660
Cdd:pfam00517  70 YKWICVTKVPYNASdpwdKVKKHLQGIWNNT-------EVSYDLLQLHNLIEDIQNQQEKTLNELDTLDNWAqSLFNWFP 142

                         170       180       190
                  ....*....|....*....|....*....|...
gi 86277544   661 ISN--WLWYirifimIVGGLIGLRIVFTVLSIV 691
Cdd:pfam00517 143 SLNslWRSY------IIAGGVGLRIVLIVLCLA 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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