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Conserved domains on  [gi|85544350]
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Chain A, LENS FIBER MAJOR INTRINSIC PROTEIN

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
3-219 7.69e-99

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 288.06  E-value: 7.69e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350     3 ELRSASFWRAICAEFFASLFYVFFGLGASLRWAP-----GPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLV 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKlvsslAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350    78 GSQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRL 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 85544350   158 GSVA-LAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:pfam00230 161 GTVApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
3-219 7.69e-99

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 288.06  E-value: 7.69e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350     3 ELRSASFWRAICAEFFASLFYVFFGLGASLRWAP-----GPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLV 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKlvsslAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350    78 GSQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRL 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 85544350   158 GSVA-LAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:pfam00230 161 GTVApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
11-222 3.00e-75

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 228.29  E-value: 3.00e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350  11 RAICAEFFASLFYVFFGLGASLRWAPG---PLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAI 87
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAggaSGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350  88 CYMVAQLLGAVAGAAVLYSVTPPAVRGNLALN---------TLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLG 158
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANnivagifgtYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPPG 160
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 85544350 159 SVA-LAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFT---NHWVYWVGPVIGAGLGSLLYDFL 222
Cdd:cd00333 161 GLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwhYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
15-219 1.74e-74

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 226.03  E-value: 1.74e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350    15 AEFFASLFYVFFGLGASL-------RWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAI 87
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350    88 CYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLH-PGVSVGQATIVEIFLTLQFVLCIFATYDERRNG-RLGSVALAVG 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSAsAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVpRGGFAPLAIG 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 85544350   166 FSLTLGHLFGMYYTGAGMNPARSFAPAILTR--NFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
8-223 6.13e-53

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 171.46  E-value: 6.13e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   8 SFWRAICAEFFASLFYVFFGLG--ASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLR 85
Cdd:COG0580   1 SLMKRLLAEFLGTFILVLLGCGvvAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350  86 AICYMVAQLLGAVAGAAVLYSVTPPAVRG-NLALNTLH-------PGVSVGQATIVEIFLTLQFVLCIFATYDERR-NGR 156
Cdd:COG0580  81 VLPYIIAQLLGAFLGAALVYLIYGGHFDAtEDGGAKLGvfatspaIGYSLGAAFLTEIIGTFVLVFVILGITDKRAaPGG 160
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 85544350 157 LGsvALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAIL------TRNFTNHWVYWVGPVIGAGLGSLLYDFLL 223
Cdd:COG0580 161 LA--PLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00027 PLN00027
aquaporin TIP; Provisional
11-222 2.77e-44

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 149.94  E-value: 2.77e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   11 RAICAEFFASLFYVFFGLGASLRW-------APGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSL 83
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFnkltdngSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNITL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   84 LRAICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNtlhPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLGSVA-L 162
Cdd:PLN00027 101 LRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLS---SGVGVWNAFVFEIVMTFGLVYTVYATAVDPKKGDLGIIApI 177
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350  163 AVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFL 222
Cdd:PLN00027 178 AIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
3-219 7.69e-99

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 288.06  E-value: 7.69e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350     3 ELRSASFWRAICAEFFASLFYVFFGLGASLRWAP-----GPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLV 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKlvsslAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350    78 GSQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRL 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 85544350   158 GSVA-LAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:pfam00230 161 GTVApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
11-222 3.00e-75

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 228.29  E-value: 3.00e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350  11 RAICAEFFASLFYVFFGLGASLRWAPG---PLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAI 87
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVKLAggaSGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350  88 CYMVAQLLGAVAGAAVLYSVTPPAVRGNLALN---------TLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLG 158
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANnivagifgtYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPPG 160
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 85544350 159 SVA-LAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFT---NHWVYWVGPVIGAGLGSLLYDFL 222
Cdd:cd00333 161 GLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwhYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
15-219 1.74e-74

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 226.03  E-value: 1.74e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350    15 AEFFASLFYVFFGLGASL-------RWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAI 87
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350    88 CYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLH-PGVSVGQATIVEIFLTLQFVLCIFATYDERRNG-RLGSVALAVG 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSAsAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVpRGGFAPLAIG 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 85544350   166 FSLTLGHLFGMYYTGAGMNPARSFAPAILTR--NFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGlaGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
8-223 6.13e-53

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 171.46  E-value: 6.13e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   8 SFWRAICAEFFASLFYVFFGLG--ASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLR 85
Cdd:COG0580   1 SLMKRLLAEFLGTFILVLLGCGvvAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350  86 AICYMVAQLLGAVAGAAVLYSVTPPAVRG-NLALNTLH-------PGVSVGQATIVEIFLTLQFVLCIFATYDERR-NGR 156
Cdd:COG0580  81 VLPYIIAQLLGAFLGAALVYLIYGGHFDAtEDGGAKLGvfatspaIGYSLGAAFLTEIIGTFVLVFVILGITDKRAaPGG 160
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 85544350 157 LGsvALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAIL------TRNFTNHWVYWVGPVIGAGLGSLLYDFLL 223
Cdd:COG0580 161 LA--PLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFhalgkgGSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00027 PLN00027
aquaporin TIP; Provisional
11-222 2.77e-44

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 149.94  E-value: 2.77e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   11 RAICAEFFASLFYVFFGLGASLRW-------APGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSL 83
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFnkltdngSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNITL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   84 LRAICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNtlhPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLGSVA-L 162
Cdd:PLN00027 101 LRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLS---SGVGVWNAFVFEIVMTFGLVYTVYATAVDPKKGDLGIIApI 177
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350  163 AVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFL 222
Cdd:PLN00027 178 AIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELI 237
PLN00166 PLN00166
aquaporin TIP2; Provisional
6-219 3.54e-36

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 128.90  E-value: 3.54e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350    6 SASFWRAICAEFFASLFYVFFGLGASLRWAP-------GPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVG 78
Cdd:PLN00166  14 SVASLKAYLSEFIATLLFVFAGVGSAIAFAKltsdaalDPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIG 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   79 SQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAvrgNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLG 158
Cdd:PLN00166  94 GNITIITGFFYWIAQCLGSIVACLLLVFVTNGE---SVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLG 170
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 85544350  159 SVA-LAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:PLN00166 171 TIApIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIY 232
PRK05420 PRK05420
aquaporin Z; Provisional
11-223 2.16e-34

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 123.54  E-value: 2.16e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   11 RAICAEFFASLFYVFFGLGASLRWAPGP---LHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAI 87
Cdd:PRK05420   3 KKLAAEFFGTFWLVFGGCGSAVLAAAFPelgIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKELV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   88 CYMVAQLLGAVAGAAVLYSVTP-----PAVRGNLALN--TLHP--GVSVGQATIVEIFLTLQFVLCIFATYDERRNGrlG 158
Cdd:PRK05420  83 PYIIAQVVGGIAAAAVLYLIASgkagfDLAGSGFASNgyGEHSpgGYSLLAALVCEVVLTAFFLLVILGATDKRAPA--G 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 85544350  159 SVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNF--TNHWVYWVGPVIGAGLGSLLYDFLL 223
Cdd:PRK05420 161 FAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWalEQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00167 PLN00167
aquaporin TIP5; Provisional
11-225 1.21e-32

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 120.01  E-value: 1.21e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   11 RAICAEFFASLFYVFFGLGASLR-------WAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSL 83
Cdd:PLN00167  23 RSYLAEFISTFFFVFAAVGSAMSsrklmpdAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   84 LRAICYMVAQLLGAVAgAAVLYSVTppAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRnGRLGSVA-L 162
Cdd:PLN00167 103 PTAMFYWISQMLASVM-ACLFLKVT--TVGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRR-GLLGAIGpL 178
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 85544350  163 AVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFLLFP 225
Cdd:PLN00167 179 AIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVFP 241
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
15-245 6.28e-28

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 108.07  E-value: 6.28e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   15 AEFFASLFYVFFGLGASL--RWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAICYMVA 92
Cdd:PLN00182  47 AEMIGTYFIIFSGCGVVVvnVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVPLYIGA 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   93 QLLGAVAGA---AVLYSVTPPAVRGNLalntlhPGVSVGQATIVEIFLT--LQFVLCIFATyDERRNGRLGSVAlaVGFS 167
Cdd:PLN00182 127 QLTGSLLASltlRLMFNVTPEAFFGTT------PTDSSGQALVAEIIISflLMFVISGVAT-DSRAVGELAGIA--VGMT 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350  168 LTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFLLFPR--LKSVSERLSILKGSRPSES 245
Cdd:PLN00182 198 IILNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVYIVGPFVGIIAGGFVYNLIRFTDkpLRELTKSASFLRSVSQKHN 277
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
2-225 2.05e-27

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 107.13  E-value: 2.05e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350    2 WELRS-ASFWRAICAEFFASLFYVFFGLG--ASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVG 78
Cdd:PTZ00016  41 WAPREyRPNVREYVAEFLGTFVLLFFGEGvvATTHTVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVF 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   79 SQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAVR--------------GNLALNTLHPGVSVGQATIVEIFLTLQFVLC 144
Cdd:PTZ00016 121 GKFPWKKLPGYFVAQLLGAFVGAACVYGLYYGFFKdhgipelpwetmanGFAGVFATYPREGNFYAIFSELILTAILLLV 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350  145 IFATYDERRNGRLGSVALAVGFS-LTLGHLFGmYYTGAGMNPARSFAPAILT------RNFTNH----WVYWVGPVIGAG 213
Cdd:PTZ00016 201 ILAITDPNNCPAFNYLPVAVGLLvFVIGISFG-GNTGYALNPARDLGPRLFSailwgsEVFTKDnyyfWVPLVAPFVGAV 279
                        250
                 ....*....|..
gi 85544350  214 LGSLLYDFLLFP 225
Cdd:PTZ00016 280 LGMFLYDKFIPP 291
PLN00026 PLN00026
aquaporin NIP; Provisional
8-219 4.48e-26

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 103.40  E-value: 4.48e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350    8 SFWRAICAEFFASLFYVFFGLGASL--RWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLR 85
Cdd:PLN00026  69 SLTRKLGAEFVGTFILIFAATAGPIvnQKYDGAETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKH 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   86 AICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALntlhPGVSVGQATIVEIFLT--LQFVLCIFATyDERRNGRLGSVAla 163
Cdd:PLN00026 149 VPAYIAAQVSASICASFALKGVFHPFMSGGVTV----PSVSTGQAFALEFIITfnLLFVVTAVAT-DTRAVGELAGIA-- 221
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 85544350  164 VGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLY 219
Cdd:PLN00026 222 VGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTY 277
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
11-222 2.69e-25

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 100.70  E-value: 2.69e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   11 RAICAEFFASLFYVF--FGLGASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAIC 88
Cdd:PLN00183  46 RMVLAEMVGTFILMFcvCGIIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPL 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   89 YMVAQLLGAVAGAAVLYSVTPPavrgNLALNTLHPGVSVGQATIVEIFLTLQFV-LCIFATYDERRNGRLGsvALAVGFS 167
Cdd:PLN00183 126 YITAQTVGSVLATYVGVSVYGV----KADLMTTKPAQGCSSAFWVEFIATFIVMfLAASLTSQPQSLGHLS--GFVIGIA 199
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 85544350  168 LTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFL 222
Cdd:PLN00183 200 IGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFHLL 254
PLN00184 PLN00184
aquaporin NIP1; Provisional
6-241 3.68e-25

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 100.87  E-value: 3.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350    6 SASFWRAICAEFFASLFYVFFGLGA--------SLRWAPGplhvlqVALAFGLALATLVQAVGHISGAHVNPAVTFAFLV 77
Cdd:PLN00184  50 SVPFLQKLIAEVLGTYFLVFTGCASvvvnmqndNVVTLPG------IAIVWGLTIMVLIYSLGHISGAHINPAVTIAFAS 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350   78 GSQMSLLRAICYMVAQLLGAVAGAA---VLYSVTPPAVRG--NLALNTLHPGVSVgQATIVEIFLT--LQFVLCIFATyD 150
Cdd:PLN00184 124 CGRFPLKQVPAYVISQVIGSTLAAAtlrLLFGLDHDVCSGkhDVFIGSSPVGSDL-QAFVMEFIVTfyLMFIISGVAT-D 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85544350  151 ERRNGRLGsvALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFLLFPR--LK 228
Cdd:PLN00184 202 NRAIGELA--GLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTVRYTDkpLR 279
                        250
                 ....*....|...
gi 85544350  229 SVSERLSILKGSR 241
Cdd:PLN00184 280 EITKSGSFLKTVR 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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