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Conserved domains on  [gi|85386547|ref|NP_570856|]
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V-type proton ATPase 116 kDa subunit a 4 [Homo sapiens]

Protein Classification

V-type ATPase subunit a family protein( domain architecture ID 11119844)

V-type ATPase 116kDa subunit a family protein such as vertebrate V-type proton ATPase 116 kDa subunit a and plant/yeast V-type proton ATPase subunit a, an essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes

Gene Ontology:  GO:0042625|GO:0033176|GO:1902600
PubMed:  9210392|10224039
SCOP:  4001703

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
V_ATPase_I pfam01496
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
27-830 0e+00

V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.


:

Pssm-ID: 460232 [Multi-domain]  Cd Length: 748  Bit Score: 1255.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547    27 AELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERILRFLEDEMQNE----IVVQLLEKSPLTPLPREMITLETVLEK 102
Cdd:pfam01496   1 SELGELGLVQFRDLNPDVNAFQRTFVNEIRRCDEMERKLRFFEEEIEKLdiipIKDTLDLETPEAPSPREIDELEEKLEK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   103 LEGELQEANQNQQALKQSFLELTELKYLLKKTQDFFETetNLADDFFTEDTSGLLELKAVPAYMTGKLGFIAGVINRERM 182
Cdd:pfam01496  81 LENELRELNENYETLKRNYNELTELRHVLRKAQEFFDR--ASGEQEEIRAASSDQEEDNALLLDDVELGFVAGVIPREKV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   183 ASFERLLWRICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEPAVERREMLES 262
Cdd:pfam01496 159 PAFERILWRATRGNLFLRQAEIEEPLEDPVTGEEVEKNVFIIFFHGEQLLQKIKKICESFGATLYPCPEDAEERREMLQE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   263 VNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVTQQCVIAEIWFPVADATRIKRALEQG 342
Cdd:pfam01496 239 VNTRIEDLKTVLDQTEDHRRRELQAIASNLEEWKIFVRKEKAIYHTLNLFNYDVTRKCLIAEGWCPTSDLEEIQQALRRA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   343 MELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAA 422
Cdd:pfam01496 319 TEESGSSVPSILNVIQTNKTPPTYFRTNKFTEGFQNIVDAYGIARYREVNPGLFTIITFPFLFAVMFGDIGHGLILFLFA 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   423 LWMILNERRLLSQKtDNEIWNTFFHGRYLILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESLy 502
Cdd:pfam01496 399 LYLILNEKKLKKKK-LNEIFDMFFGGRYIILLMGLFSIYTGFIYNDFFSKSLNLFGSGWKWPEMKEGESIAKKNGYLTL- 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   503 lqldpaipgvyFGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIPEMIF 582
Cdd:pfam01496 477 -----------FGCPYPFGLDPAWHGAENELLFLNSYKMKLSIILGVIHMTFGICLSLFNHIYFKSKLDIFFEFIPQLLF 545
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   583 ILCLFGYLVFMIIFKWCCFDVHVSQhAPSILIHFINMFLFNYSDSSNAPLYKHQQEVQSFFVVMALISVPWMLLIKPFIL 662
Cdd:pfam01496 546 LQSIFGYLVFLIIYKWCTDWADGSP-APSLLNMLINMFLSPGTVPPEEPLYPGQATVQVILLLIALICVPWMLLPKPLYL 624
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   663 RASHRKsqlqasriqedateniegdssspssrsgqrtsadthgalddhgeeFNFGDVFVHQAIHTIEYCLGCISNTASYL 742
Cdd:pfam01496 625 KRQHKK---------------------------------------------FDFGEIFIHQVIHTIEFVLGCISNTASYL 659
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   743 RLWALSLAHAQLSEVLWTMVM-NSGLQTRGWGGIVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGD 821
Cdd:pfam01496 660 RLWALSLAHAQLSEVLWEMTLrNAGLGMGGILGVIMLFIGFAVWAVLTVAILLVMEGLSAFLHALRLHWVEFQSKFYKGD 739

                  ....*....
gi 85386547   822 GYKFSPFSF 830
Cdd:pfam01496 740 GYKFEPFSF 748
 
Name Accession Description Interval E-value
V_ATPase_I pfam01496
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
27-830 0e+00

V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.


Pssm-ID: 460232 [Multi-domain]  Cd Length: 748  Bit Score: 1255.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547    27 AELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERILRFLEDEMQNE----IVVQLLEKSPLTPLPREMITLETVLEK 102
Cdd:pfam01496   1 SELGELGLVQFRDLNPDVNAFQRTFVNEIRRCDEMERKLRFFEEEIEKLdiipIKDTLDLETPEAPSPREIDELEEKLEK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   103 LEGELQEANQNQQALKQSFLELTELKYLLKKTQDFFETetNLADDFFTEDTSGLLELKAVPAYMTGKLGFIAGVINRERM 182
Cdd:pfam01496  81 LENELRELNENYETLKRNYNELTELRHVLRKAQEFFDR--ASGEQEEIRAASSDQEEDNALLLDDVELGFVAGVIPREKV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   183 ASFERLLWRICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEPAVERREMLES 262
Cdd:pfam01496 159 PAFERILWRATRGNLFLRQAEIEEPLEDPVTGEEVEKNVFIIFFHGEQLLQKIKKICESFGATLYPCPEDAEERREMLQE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   263 VNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVTQQCVIAEIWFPVADATRIKRALEQG 342
Cdd:pfam01496 239 VNTRIEDLKTVLDQTEDHRRRELQAIASNLEEWKIFVRKEKAIYHTLNLFNYDVTRKCLIAEGWCPTSDLEEIQQALRRA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   343 MELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAA 422
Cdd:pfam01496 319 TEESGSSVPSILNVIQTNKTPPTYFRTNKFTEGFQNIVDAYGIARYREVNPGLFTIITFPFLFAVMFGDIGHGLILFLFA 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   423 LWMILNERRLLSQKtDNEIWNTFFHGRYLILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESLy 502
Cdd:pfam01496 399 LYLILNEKKLKKKK-LNEIFDMFFGGRYIILLMGLFSIYTGFIYNDFFSKSLNLFGSGWKWPEMKEGESIAKKNGYLTL- 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   503 lqldpaipgvyFGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIPEMIF 582
Cdd:pfam01496 477 -----------FGCPYPFGLDPAWHGAENELLFLNSYKMKLSIILGVIHMTFGICLSLFNHIYFKSKLDIFFEFIPQLLF 545
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   583 ILCLFGYLVFMIIFKWCCFDVHVSQhAPSILIHFINMFLFNYSDSSNAPLYKHQQEVQSFFVVMALISVPWMLLIKPFIL 662
Cdd:pfam01496 546 LQSIFGYLVFLIIYKWCTDWADGSP-APSLLNMLINMFLSPGTVPPEEPLYPGQATVQVILLLIALICVPWMLLPKPLYL 624
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   663 RASHRKsqlqasriqedateniegdssspssrsgqrtsadthgalddhgeeFNFGDVFVHQAIHTIEYCLGCISNTASYL 742
Cdd:pfam01496 625 KRQHKK---------------------------------------------FDFGEIFIHQVIHTIEFVLGCISNTASYL 659
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   743 RLWALSLAHAQLSEVLWTMVM-NSGLQTRGWGGIVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGD 821
Cdd:pfam01496 660 RLWALSLAHAQLSEVLWEMTLrNAGLGMGGILGVIMLFIGFAVWAVLTVAILLVMEGLSAFLHALRLHWVEFQSKFYKGD 739

                  ....*....
gi 85386547   822 GYKFSPFSF 830
Cdd:pfam01496 740 GYKFEPFSF 748
NtpI COG1269
Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal ...
26-831 6.34e-49

Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 is part of the Pathway/BioSystem: A/V-type ATP synthase


Pssm-ID: 440880 [Multi-domain]  Cd Length: 645  Bit Score: 183.95  E-value: 6.34e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  26 VAELGELGLVQFKDLNMNVNSFQ----RKFVNEVRRCES----LERILRFLEDEMQNEIVVQLLEKSPLTPLPREmitLE 97
Cdd:COG1269  22 LEALQELGVVHIEDLDEELEEEEglkpGEPDEELEELSEllsrLRSALSILGPYLEEKGGLKPKKEVTLEELEEE---LE 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  98 TVLEKLEGELQEANQNQQALKQSFLELTELKYLLKKTQDFfetetnladdffTEDTSGLLELKavpaymtgKLGFIAGVI 177
Cdd:COG1269  99 EELEEIEEEVNELEERLEELEEELEELEELIEALEPWGDL------------DIDLEELRGTK--------YLSVRVGTV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 178 NRERMASFERLLwricrgnvylkfSEMDAPLEdPVTKEEIQKNIFIIFYQGEQlRQKIKKICDGFRATVYPCPEPAVERR 257
Cdd:COG1269 159 PKENLEKLKKAL------------EILADYVE-VVSSDKEDEVYVVVIVPKED-EEEVEEVLRSLGFERLEIPELEGTPS 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 258 EMLESVNVRLEDLITVITQTESHRQRLLQEAAAN---WHSWL-IKVQKMKAvyhILNMCNidvTQQCVIAEIWFPVADAT 333
Cdd:COG1269 225 EALEELEEEIEELEKEIEELEKELEELAEKYREDllaLYEYLeIEKEKAEA---PLKLAT---TENLFVLEGWVPEEEVE 298
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 334 RIKRALEqgmELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCG 413
Cdd:COG1269 299 ELEKALE---KATGGRVYVEEEDPEEDDEPPTLLKNPKFVKPFELLVEMYGLPKYGEIDPTPFFALFFPLFFGMMFGDAG 375
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 414 HGTVMLLAALWMIlneRRLLSQKtdneiWNTFFhgrYLILLMGIFSIYTGLIYndcfskslnifGSswsvqpmfrngtwn 493
Cdd:COG1269 376 YGLLLLLAGLLLL---KKFLSKG-----LKKLG---KLLLYLGISTIIFGLLY-----------GS-------------- 419
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 494 thvmeeslylqldpaipgvYFGN-PYPFGIDPIWNLASNKLTFLnsykMKMSVILGIVQMVFGVILSLFNHIYFRRTLNI 572
Cdd:COG1269 420 -------------------FFGFeLLAGLLPALWLDPLEDPNTM----LVLSLAIGVIHLLLGLILGIYNLLKRGDYKDA 476
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 573 ILQFIPEMIFILclfgylvfmiifkwccfdvhvsqhapSILIhfinmFLFNYSDSSNAPLYkhqqevqSFFVVMALISVP 652
Cdd:COG1269 477 LLDQGGWLLLLL--------------------------GLLL-----LVLGLVLGGPLPLT-------TIGLVLLIIGLV 518
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 653 WMLLikpfilrashrKSQLQASRIQEDATENIEGdssspssrsgqrtsadthgalddhgeefnfgdvfvhqaihTIEYcL 732
Cdd:COG1269 519 LLLL-----------FGGRSGKNIGGRLGEGLFG----------------------------------------LYEI-T 546
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 733 GCISNTASYLRLWALSLAHAQLSEVLWTMVMNSglqtrGWGGIVGvFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVE 812
Cdd:COG1269 547 GYLSDVLSYIRLFALGLASAGLAMVVNTLAGMV-----GGGPIVG-IIGGILILILGHLLNIALEGLGAFVHSLRLQYVE 620
                       810
                ....*....|....*....
gi 85386547 813 FQNKFYVGDGYKFSPFSFK 831
Cdd:COG1269 621 FFGKFYEGGGKPFKPFKLK 639
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
26-828 2.91e-39

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 155.09  E-value: 2.91e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   26 VAELGELGLVQFKDLNMNVNSFQrkfVNEVRR-CESLERILRFLEDEMQ---------NEIVVQLLEKSpLTPLPREMIT 95
Cdd:PRK05771  22 LEALHELGVVHIEDLKEELSNER---LRKLRSlLTKLSEALDKLRSYLPklnplreekKKVSVKSLEEL-IKDVEEELEK 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   96 LETVLEKLEGELQEANQNQQALKQsflELTELKYLLKktqdffetetnladdfFTEDTSGLLELKAVpaymtgklGFIAG 175
Cdd:PRK05771  98 IEKEIKELEEEISELENEIKELEQ---EIERLEPWGN----------------FDLDLSLLLGFKYV--------SVFVG 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  176 VINRErmaSFERLLWRICRGNVYlkfsemdapledpVTKEEIQKNIFIIFY---QGEQLRQKIKKIcdGFRATVYPCPEP 252
Cdd:PRK05771 151 TVPED---KLEELKLESDVENVE-------------YISTDKGYVYVVVVVlkeLSDEVEEELKKL--GFERLELEEEGT 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  253 AVERREMLESvnvRLEDLITVITQTESH----RQRLLQEAAANWHSWLIKVQKMKAvyhilnMCNIDVTQQCVIAEIWFP 328
Cdd:PRK05771 213 PSELIREIKE---ELEEIEKERESLLEElkelAKKYLEELLALYEYLEIELERAEA------LSKFLKTDKTFAIEGWVP 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  329 VADATRIKRALEQgmELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVM 408
Cdd:PRK05771 284 EDRVKKLKELIDK--ATGGSAYVEFVEPDEEEEEVPTKLKNPKFIKPFESLTEMYSLPKYNEIDPTPFLAIFFPLFFGMM 361
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  409 FGDCGHGTVMLLAALWMILNERRLlsqktdNEIWNTFFhgrYLILLMGIFSIYTGLIYNDCfskslniFGSSWSVQPMFR 488
Cdd:PRK05771 362 LGDAGYGLLLLLIGLLLSFKLKKK------SEGLKRLL---KILIYLGISTIIWGLLTGSF-------FGFSLPIFLPGG 425
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  489 ngtwnthvmeeslyLQLDPAIPGVYFGNPYPFGIdpiwnlasnkltflnsykMKMSVILGIVQMVFGVILSLFNHIYFRR 568
Cdd:PRK05771 426 --------------YLELPEGYPSLSTENDVMTI------------------LIISLLIGVIHLFLGLLLGFINNVRKGD 473
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  569 TLNIILQFIPEMIFILclfgylvfmiifkwccfdvhvsqhapSILIHFINMFLFNysdSSNAPLYkhqqevqsfFVVMAL 648
Cdd:PRK05771 474 YKDAFLAQLGWLLILL--------------------------GILLIVLGGFGLV---VGLGPLG---------LIGKYL 515
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  649 ISVpWMLLIkpFILRASHRKSQLQASRIQEdATENIegdssspssrsgqrtsadthgalddhgeefnfgdvfvhqaihti 728
Cdd:PRK05771 516 IIG-GVVLI--ILGEGIDGKSLGGALGGLG-LYEIT-------------------------------------------- 547
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  729 eyclGCISNTASYLRLWALSLAHAQLSEVLWTMVMnSGLQTRGWGGIVGVFIIFAVFAVLTvailLIMEGLSAFLHALRL 808
Cdd:PRK05771 548 ----GYLGDVLSYARLMALGLAGAGIAMAFNLMAG-LLPPSIGVIGIIVGIIIFIFGHLLN----IALSILGAFVHGLRL 618
                        810       820
                 ....*....|....*....|
gi 85386547  809 HWVEFQNKFYVGDGYKFSPF 828
Cdd:PRK05771 619 HYVEFFGKFYEGGGKKFNPF 638
 
Name Accession Description Interval E-value
V_ATPase_I pfam01496
V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase ...
27-830 0e+00

V-type ATPase 116kDa subunit family; This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1.


Pssm-ID: 460232 [Multi-domain]  Cd Length: 748  Bit Score: 1255.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547    27 AELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERILRFLEDEMQNE----IVVQLLEKSPLTPLPREMITLETVLEK 102
Cdd:pfam01496   1 SELGELGLVQFRDLNPDVNAFQRTFVNEIRRCDEMERKLRFFEEEIEKLdiipIKDTLDLETPEAPSPREIDELEEKLEK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   103 LEGELQEANQNQQALKQSFLELTELKYLLKKTQDFFETetNLADDFFTEDTSGLLELKAVPAYMTGKLGFIAGVINRERM 182
Cdd:pfam01496  81 LENELRELNENYETLKRNYNELTELRHVLRKAQEFFDR--ASGEQEEIRAASSDQEEDNALLLDDVELGFVAGVIPREKV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   183 ASFERLLWRICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEPAVERREMLES 262
Cdd:pfam01496 159 PAFERILWRATRGNLFLRQAEIEEPLEDPVTGEEVEKNVFIIFFHGEQLLQKIKKICESFGATLYPCPEDAEERREMLQE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   263 VNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVTQQCVIAEIWFPVADATRIKRALEQG 342
Cdd:pfam01496 239 VNTRIEDLKTVLDQTEDHRRRELQAIASNLEEWKIFVRKEKAIYHTLNLFNYDVTRKCLIAEGWCPTSDLEEIQQALRRA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   343 MELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAA 422
Cdd:pfam01496 319 TEESGSSVPSILNVIQTNKTPPTYFRTNKFTEGFQNIVDAYGIARYREVNPGLFTIITFPFLFAVMFGDIGHGLILFLFA 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   423 LWMILNERRLLSQKtDNEIWNTFFHGRYLILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESLy 502
Cdd:pfam01496 399 LYLILNEKKLKKKK-LNEIFDMFFGGRYIILLMGLFSIYTGFIYNDFFSKSLNLFGSGWKWPEMKEGESIAKKNGYLTL- 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   503 lqldpaipgvyFGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIPEMIF 582
Cdd:pfam01496 477 -----------FGCPYPFGLDPAWHGAENELLFLNSYKMKLSIILGVIHMTFGICLSLFNHIYFKSKLDIFFEFIPQLLF 545
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   583 ILCLFGYLVFMIIFKWCCFDVHVSQhAPSILIHFINMFLFNYSDSSNAPLYKHQQEVQSFFVVMALISVPWMLLIKPFIL 662
Cdd:pfam01496 546 LQSIFGYLVFLIIYKWCTDWADGSP-APSLLNMLINMFLSPGTVPPEEPLYPGQATVQVILLLIALICVPWMLLPKPLYL 624
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   663 RASHRKsqlqasriqedateniegdssspssrsgqrtsadthgalddhgeeFNFGDVFVHQAIHTIEYCLGCISNTASYL 742
Cdd:pfam01496 625 KRQHKK---------------------------------------------FDFGEIFIHQVIHTIEFVLGCISNTASYL 659
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   743 RLWALSLAHAQLSEVLWTMVM-NSGLQTRGWGGIVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGD 821
Cdd:pfam01496 660 RLWALSLAHAQLSEVLWEMTLrNAGLGMGGILGVIMLFIGFAVWAVLTVAILLVMEGLSAFLHALRLHWVEFQSKFYKGD 739

                  ....*....
gi 85386547   822 GYKFSPFSF 830
Cdd:pfam01496 740 GYKFEPFSF 748
NtpI COG1269
Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal ...
26-831 6.34e-49

Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 is part of the Pathway/BioSystem: A/V-type ATP synthase


Pssm-ID: 440880 [Multi-domain]  Cd Length: 645  Bit Score: 183.95  E-value: 6.34e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  26 VAELGELGLVQFKDLNMNVNSFQ----RKFVNEVRRCES----LERILRFLEDEMQNEIVVQLLEKSPLTPLPREmitLE 97
Cdd:COG1269  22 LEALQELGVVHIEDLDEELEEEEglkpGEPDEELEELSEllsrLRSALSILGPYLEEKGGLKPKKEVTLEELEEE---LE 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  98 TVLEKLEGELQEANQNQQALKQSFLELTELKYLLKKTQDFfetetnladdffTEDTSGLLELKavpaymtgKLGFIAGVI 177
Cdd:COG1269  99 EELEEIEEEVNELEERLEELEEELEELEELIEALEPWGDL------------DIDLEELRGTK--------YLSVRVGTV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 178 NRERMASFERLLwricrgnvylkfSEMDAPLEdPVTKEEIQKNIFIIFYQGEQlRQKIKKICDGFRATVYPCPEPAVERR 257
Cdd:COG1269 159 PKENLEKLKKAL------------EILADYVE-VVSSDKEDEVYVVVIVPKED-EEEVEEVLRSLGFERLEIPELEGTPS 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 258 EMLESVNVRLEDLITVITQTESHRQRLLQEAAAN---WHSWL-IKVQKMKAvyhILNMCNidvTQQCVIAEIWFPVADAT 333
Cdd:COG1269 225 EALEELEEEIEELEKEIEELEKELEELAEKYREDllaLYEYLeIEKEKAEA---PLKLAT---TENLFVLEGWVPEEEVE 298
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 334 RIKRALEqgmELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCG 413
Cdd:COG1269 299 ELEKALE---KATGGRVYVEEEDPEEDDEPPTLLKNPKFVKPFELLVEMYGLPKYGEIDPTPFFALFFPLFFGMMFGDAG 375
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 414 HGTVMLLAALWMIlneRRLLSQKtdneiWNTFFhgrYLILLMGIFSIYTGLIYndcfskslnifGSswsvqpmfrngtwn 493
Cdd:COG1269 376 YGLLLLLAGLLLL---KKFLSKG-----LKKLG---KLLLYLGISTIIFGLLY-----------GS-------------- 419
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 494 thvmeeslylqldpaipgvYFGN-PYPFGIDPIWNLASNKLTFLnsykMKMSVILGIVQMVFGVILSLFNHIYFRRTLNI 572
Cdd:COG1269 420 -------------------FFGFeLLAGLLPALWLDPLEDPNTM----LVLSLAIGVIHLLLGLILGIYNLLKRGDYKDA 476
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 573 ILQFIPEMIFILclfgylvfmiifkwccfdvhvsqhapSILIhfinmFLFNYSDSSNAPLYkhqqevqSFFVVMALISVP 652
Cdd:COG1269 477 LLDQGGWLLLLL--------------------------GLLL-----LVLGLVLGGPLPLT-------TIGLVLLIIGLV 518
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 653 WMLLikpfilrashrKSQLQASRIQEDATENIEGdssspssrsgqrtsadthgalddhgeefnfgdvfvhqaihTIEYcL 732
Cdd:COG1269 519 LLLL-----------FGGRSGKNIGGRLGEGLFG----------------------------------------LYEI-T 546
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547 733 GCISNTASYLRLWALSLAHAQLSEVLWTMVMNSglqtrGWGGIVGvFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVE 812
Cdd:COG1269 547 GYLSDVLSYIRLFALGLASAGLAMVVNTLAGMV-----GGGPIVG-IIGGILILILGHLLNIALEGLGAFVHSLRLQYVE 620
                       810
                ....*....|....*....
gi 85386547 813 FQNKFYVGDGYKFSPFSFK 831
Cdd:COG1269 621 FFGKFYEGGGKPFKPFKLK 639
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
26-828 2.91e-39

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 155.09  E-value: 2.91e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   26 VAELGELGLVQFKDLNMNVNSFQrkfVNEVRR-CESLERILRFLEDEMQ---------NEIVVQLLEKSpLTPLPREMIT 95
Cdd:PRK05771  22 LEALHELGVVHIEDLKEELSNER---LRKLRSlLTKLSEALDKLRSYLPklnplreekKKVSVKSLEEL-IKDVEEELEK 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547   96 LETVLEKLEGELQEANQNQQALKQsflELTELKYLLKktqdffetetnladdfFTEDTSGLLELKAVpaymtgklGFIAG 175
Cdd:PRK05771  98 IEKEIKELEEEISELENEIKELEQ---EIERLEPWGN----------------FDLDLSLLLGFKYV--------SVFVG 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  176 VINRErmaSFERLLWRICRGNVYlkfsemdapledpVTKEEIQKNIFIIFY---QGEQLRQKIKKIcdGFRATVYPCPEP 252
Cdd:PRK05771 151 TVPED---KLEELKLESDVENVE-------------YISTDKGYVYVVVVVlkeLSDEVEEELKKL--GFERLELEEEGT 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  253 AVERREMLESvnvRLEDLITVITQTESH----RQRLLQEAAANWHSWLIKVQKMKAvyhilnMCNIDVTQQCVIAEIWFP 328
Cdd:PRK05771 213 PSELIREIKE---ELEEIEKERESLLEElkelAKKYLEELLALYEYLEIELERAEA------LSKFLKTDKTFAIEGWVP 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  329 VADATRIKRALEQgmELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVM 408
Cdd:PRK05771 284 EDRVKKLKELIDK--ATGGSAYVEFVEPDEEEEEVPTKLKNPKFIKPFESLTEMYSLPKYNEIDPTPFLAIFFPLFFGMM 361
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  409 FGDCGHGTVMLLAALWMILNERRLlsqktdNEIWNTFFhgrYLILLMGIFSIYTGLIYNDCfskslniFGSSWSVQPMFR 488
Cdd:PRK05771 362 LGDAGYGLLLLLIGLLLSFKLKKK------SEGLKRLL---KILIYLGISTIIWGLLTGSF-------FGFSLPIFLPGG 425
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  489 ngtwnthvmeeslyLQLDPAIPGVYFGNPYPFGIdpiwnlasnkltflnsykMKMSVILGIVQMVFGVILSLFNHIYFRR 568
Cdd:PRK05771 426 --------------YLELPEGYPSLSTENDVMTI------------------LIISLLIGVIHLFLGLLLGFINNVRKGD 473
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  569 TLNIILQFIPEMIFILclfgylvfmiifkwccfdvhvsqhapSILIHFINMFLFNysdSSNAPLYkhqqevqsfFVVMAL 648
Cdd:PRK05771 474 YKDAFLAQLGWLLILL--------------------------GILLIVLGGFGLV---VGLGPLG---------LIGKYL 515
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  649 ISVpWMLLIkpFILRASHRKSQLQASRIQEdATENIegdssspssrsgqrtsadthgalddhgeefnfgdvfvhqaihti 728
Cdd:PRK05771 516 IIG-GVVLI--ILGEGIDGKSLGGALGGLG-LYEIT-------------------------------------------- 547
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85386547  729 eyclGCISNTASYLRLWALSLAHAQLSEVLWTMVMnSGLQTRGWGGIVGVFIIFAVFAVLTvailLIMEGLSAFLHALRL 808
Cdd:PRK05771 548 ----GYLGDVLSYARLMALGLAGAGIAMAFNLMAG-LLPPSIGVIGIIVGIIIFIFGHLLN----IALSILGAFVHGLRL 618
                        810       820
                 ....*....|....*....|
gi 85386547  809 HWVEFQNKFYVGDGYKFSPF 828
Cdd:PRK05771 619 HYVEFFGKFYEGGGKKFNPF 638
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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