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pterin-4a-carbinolamine dehydratase [Homo sapiens]
4a-hydroxytetrahydrobiopterin dehydratase( domain architecture ID 10097041)
4a-hydroxytetrahydrobiopterin dehydratase catalyzes the conversion from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin to (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin in tetrahydrobiopterin biosynthesis
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
PCD_DCoH_subfamily_b | cd00914 | PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known ... |
24-99 | 1.52e-50 | ||
PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating with specific DNA binding proteins such as HNF-1alpha (hepatocyte nuclear factor-1) and Xenopus enhancer of rudimentary homologue (XERH). DCoH also catalyzes the dehydration of 4alpha- hydroxy- tetrahydrobiopterin (4alpha-OH-BH4) to quinoiddihydrobiopterin, a percursor of the phenylalanine hydroxylase cofactor BH4 (tetrahydrobiopterin). The DCoH homodimer has a saddle-shaped structure similar to that of TBP (TATA binding protein). Two DCoH proteins have been identifed in humans: DCoH1 and DCoH2. Mutations in human DCoH1 cause hyperphenylalaninemia. Loss of enzymic activity of DCoH in humans is associated with the depigmentation disorder vitiligo. DCoH1 has been reported to be overexpessed in colon cancer carcinomas and in malignant melanomas. : Pssm-ID: 238456 Cd Length: 76 Bit Score: 153.92 E-value: 1.52e-50
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Name | Accession | Description | Interval | E-value | |||
PCD_DCoH_subfamily_b | cd00914 | PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known ... |
24-99 | 1.52e-50 | |||
PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating with specific DNA binding proteins such as HNF-1alpha (hepatocyte nuclear factor-1) and Xenopus enhancer of rudimentary homologue (XERH). DCoH also catalyzes the dehydration of 4alpha- hydroxy- tetrahydrobiopterin (4alpha-OH-BH4) to quinoiddihydrobiopterin, a percursor of the phenylalanine hydroxylase cofactor BH4 (tetrahydrobiopterin). The DCoH homodimer has a saddle-shaped structure similar to that of TBP (TATA binding protein). Two DCoH proteins have been identifed in humans: DCoH1 and DCoH2. Mutations in human DCoH1 cause hyperphenylalaninemia. Loss of enzymic activity of DCoH in humans is associated with the depigmentation disorder vitiligo. DCoH1 has been reported to be overexpessed in colon cancer carcinomas and in malignant melanomas. Pssm-ID: 238456 Cd Length: 76 Bit Score: 153.92 E-value: 1.52e-50
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phhB | PRK00823 | pterin-4-alpha-carbinolamine dehydratase; Validated |
3-100 | 4.95e-44 | |||
pterin-4-alpha-carbinolamine dehydratase; Validated Pssm-ID: 234845 Cd Length: 97 Bit Score: 138.05 E-value: 4.95e-44
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Pterin_4a | pfam01329 | Pterin 4 alpha carbinolamine dehydratase; Pterin 4 alpha carbinolamine dehydratase is also ... |
8-98 | 1.27e-38 | |||
Pterin 4 alpha carbinolamine dehydratase; Pterin 4 alpha carbinolamine dehydratase is also known as DCoH (dimerization cofactor of hepatocyte nuclear factor 1-alpha). Pssm-ID: 460161 Cd Length: 88 Bit Score: 124.12 E-value: 1.27e-38
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PhhB | COG2154 | Pterin-4a-carbinolamine dehydratase [Coenzyme transport and metabolism]; |
4-100 | 1.09e-36 | |||
Pterin-4a-carbinolamine dehydratase [Coenzyme transport and metabolism]; Pssm-ID: 441757 Cd Length: 99 Bit Score: 119.54 E-value: 1.09e-36
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Name | Accession | Description | Interval | E-value | |||
PCD_DCoH_subfamily_b | cd00914 | PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known ... |
24-99 | 1.52e-50 | |||
PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating with specific DNA binding proteins such as HNF-1alpha (hepatocyte nuclear factor-1) and Xenopus enhancer of rudimentary homologue (XERH). DCoH also catalyzes the dehydration of 4alpha- hydroxy- tetrahydrobiopterin (4alpha-OH-BH4) to quinoiddihydrobiopterin, a percursor of the phenylalanine hydroxylase cofactor BH4 (tetrahydrobiopterin). The DCoH homodimer has a saddle-shaped structure similar to that of TBP (TATA binding protein). Two DCoH proteins have been identifed in humans: DCoH1 and DCoH2. Mutations in human DCoH1 cause hyperphenylalaninemia. Loss of enzymic activity of DCoH in humans is associated with the depigmentation disorder vitiligo. DCoH1 has been reported to be overexpessed in colon cancer carcinomas and in malignant melanomas. Pssm-ID: 238456 Cd Length: 76 Bit Score: 153.92 E-value: 1.52e-50
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phhB | PRK00823 | pterin-4-alpha-carbinolamine dehydratase; Validated |
3-100 | 4.95e-44 | |||
pterin-4-alpha-carbinolamine dehydratase; Validated Pssm-ID: 234845 Cd Length: 97 Bit Score: 138.05 E-value: 4.95e-44
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Pterin_4a | pfam01329 | Pterin 4 alpha carbinolamine dehydratase; Pterin 4 alpha carbinolamine dehydratase is also ... |
8-98 | 1.27e-38 | |||
Pterin 4 alpha carbinolamine dehydratase; Pterin 4 alpha carbinolamine dehydratase is also known as DCoH (dimerization cofactor of hepatocyte nuclear factor 1-alpha). Pssm-ID: 460161 Cd Length: 88 Bit Score: 124.12 E-value: 1.27e-38
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PhhB | COG2154 | Pterin-4a-carbinolamine dehydratase [Coenzyme transport and metabolism]; |
4-100 | 1.09e-36 | |||
Pterin-4a-carbinolamine dehydratase [Coenzyme transport and metabolism]; Pssm-ID: 441757 Cd Length: 99 Bit Score: 119.54 E-value: 1.09e-36
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PCD_DCoH | cd00488 | PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known ... |
24-99 | 5.18e-36 | |||
PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating with specific DNA binding proteins such as HNF-1alpha (hepatocyte nuclear factor-1) and Xenopus enhancer of rudimentary homologue (XERH). DCoH also catalyzes the dehydration of 4alpha- hydroxy- tetrahydrobiopterin (4alpha-OH-BH4) to quinoiddihydrobiopterin, a percursor of the phenylalanine hydroxylase cofactor BH4 (tetrahydrobiopterin). The DCoH homodimer has a saddle-shaped structure similar to that of TBP (TATA binding protein). Two DCoH proteins have been identifed in humans: DCoH1 and DCoH2. Mutations in human DCoH1 cause hyperphenylalaninemia. Loss of enzymic activity of DCoH in humans is associated with the depigmentation disorder vitiligo. DCoH1 has been reported to be overexpessed in colon cancer carcinomas and in malignant melanomas. Pssm-ID: 238272 Cd Length: 75 Bit Score: 117.24 E-value: 5.18e-36
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PCD_DCoH_subfamily_a | cd00913 | PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known ... |
24-99 | 5.42e-13 | |||
PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by associating with specific DNA binding proteins such as HNF-1alpha (hepatocyte nuclear factor-1) and Xenopus enhancer of rudimentary homologue (XERH). DCoH also catalyzes the dehydration of 4alpha- hydroxy- tetrahydrobiopterin (4alpha-OH-BH4) to quinoiddihydrobiopterin, a percursor of the phenylalanine hydroxylase cofactor BH4 (tetrahydrobiopterin). The DCoH homodimer has a saddle-shaped structure similar to that of TBP (TATA binding protein). Pssm-ID: 238455 Cd Length: 76 Bit Score: 58.78 E-value: 5.42e-13
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