|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
25-417 |
4.04e-90 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 277.14 E-value: 4.04e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 25 WRLMPLLLFCYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAV 104
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 105 SALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILkafdglnGWH 184
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL-------LLF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 185 GWQWLYLLEGLPSIAAGVLVYTLLddriahakwlsdderallernvnaeeavkshlslgavlanPRVWLMCAIYFSFVIG 264
Cdd:cd17319 155 GWRWAFIIEGLLGLLLAVLWWFYL----------------------------------------RQVWGLALGYFGINYA 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 265 LYGVGFWLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDR--TRERRWHLAVPAAMGTVGLvLAVGWAHQTGL 342
Cdd:cd17319 195 LYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGL-LLAYLTTSPVV 273
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 848355002 343 AIAALTLATMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFKQVTASNDAGLYMMAGCM 417
Cdd:cd17319 274 AVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVA 348
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
34-415 |
7.17e-79 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 249.56 E-value: 7.17e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 34 CYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAVSALTMFVTT 113
Cdd:TIGR00893 2 VTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 114 PTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAFdglngwhGWQWLYLLE 193
Cdd:TIGR00893 82 YVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHF-------SWQWAFIIE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 194 GLPSIAAGVLVYTLLDDRIAHAKWLSDDERALLERNVNAEEAVKSHL-----SLGAVLANPRVWLMCAIYFSFVIGLYGV 268
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPStpkkyQIKELLKDRRVWGLALGQFLVNIGLGFF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 269 GFWLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRWHLAVPAAMGTVGLVLAVGWAHQTGL---AIA 345
Cdd:TIGR00893 235 LTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYvniPYA 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 848355002 346 ALTLATMGI--LTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFKQVTASNDAGLYMMAG 415
Cdd:TIGR00893 315 ALALVALGFfgLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAA 386
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-417 |
1.01e-56 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 190.85 E-value: 1.01e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 17 EAAYRKVAWRLMPLLLFCYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIAR 96
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 97 IMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKA 176
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 177 FdglngwhGWQWLYLLEGLPSIAAGVLvytllddriahakwlsdderallernvnaeeavkshlslgavlanpRVWLMCA 256
Cdd:COG2271 161 F-------GWRAAFLILGLPGLLLALL----------------------------------------------RFWLLAL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 257 IYFSFVIGLYGVGFWLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRWHLAVPAAMGTVGLVLAVGW 336
Cdd:COG2271 188 AYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLAL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 337 AHQTGLAIAALTLATMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFKQVTaSNDAGLYMMAGC 416
Cdd:COG2271 268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAAL 346
|
.
gi 848355002 417 M 417
Cdd:COG2271 347 A 347
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
22-363 |
2.70e-51 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 177.83 E-value: 2.70e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 22 KVAWRLMPLLLFCYLVSYLDRVNVGFAKLQ-MAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVT 100
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 101 WGAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAfDGL 180
Cdd:cd17327 81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKI-LGV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 181 NGWHGWQWLYLLEGLPSIAAGVLVYTLLDDRIAHAKWLSDDERAL----LERNVNAEEAVKSHLSLGA-VLANPRVWLMC 255
Cdd:cd17327 160 GGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELaverLRANQTGKGDQKFKWKQIKeAFKDPRTWLLF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 256 AIYFSFVIGLYGVGFWLPTLIRATGVaDPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRWHLAVPAAMGTVGLVLAVG 335
Cdd:cd17327 240 LFFFCSQITNNGISNFLPLILKSLGF-YSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLA 318
|
330 340
....*....|....*....|....*...
gi 848355002 336 WAHQTGLAIAALTLaTMGILTAIPLFWS 363
Cdd:cd17327 319 APNPPGAYFAAYIL-GGGSYAGFPILLS 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-417 |
4.68e-41 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 150.03 E-value: 4.68e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 22 KVAWRLMPLLLFCYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTW 101
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 102 GAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAFdgln 181
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 182 gwhGWQWLYLLEGLPSIAAGVLVYTLLDDRIAHAkwlsdderallernvnAEEAVKSHLSLGAVLANPRVWLMCAIYFSF 261
Cdd:COG2223 157 ---GWRNAFLILGILLLVVAVLAWLFLRDPPAGA----------------AAAAKASLRDQLEALRDPRFWLLSLLYFGT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 262 VIGLYGVGFWLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRWHLAVPAAMGtVGLVLAVGWAHQTG 341
Cdd:COG2223 218 FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA-LGLLLLALALGSLW 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 848355002 342 LAIAALTLATMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFKQVTASNDAGLYMMAGCM 417
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLA 372
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-417 |
1.12e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 104.43 E-value: 1.12e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 31 LLFCYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAVSALTMF 110
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 111 VTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAFdglngWHGWQWLY 190
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-----GFGWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 191 LLEGLPSIAAGVLVYtllddriahakWLSDDERALLERNVNAEEAVKSHLSLGAVLANPRVWLMCAIYFSFVIGLYGVGF 270
Cdd:cd06174 156 LIAAALALLAAILLL-----------LVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFST 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 271 WLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRWHLAVPAAMGTVGLVLAVGWAHQTGLAIAALTLA 350
Cdd:cd06174 225 LLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 848355002 351 tMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFKQVTASNDAGLYMMAGCM 417
Cdd:cd06174 305 -FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLL 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-393 |
3.38e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.50 E-value: 3.38e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 31 LLFCYLVSYLDRVNVGFA-KLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAVSALTM 109
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 110 FVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAFdglngwhGWQWL 189
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-------GWRAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 190 YLLEGLPSIAAGVLVytllddriahakWLSDDERALLERNVNAEEAVKSHLSLGAVLANPRVWLMCAIyFSFVIGLYGVG 269
Cdd:pfam07690 154 FLILAILSLLAAVLL------------LLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 270 FWLPTLIRATGVaDPLTIGLLSTVPYALAVLAMIAIARSSDRT-RERRWHLAVPAAMGTVGLVLAVGWAHQTGLAIAALT 348
Cdd:pfam07690 221 TYLPLYQEVLGL-SALLAGLLLGLGGLLGAIGRLLLGRLSDRLgRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 848355002 349 LATMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGP 393
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-364 |
1.32e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 95.43 E-value: 1.32e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 21 RKVAWRLMPLLLFCYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVT 100
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 101 WGAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAFdgl 180
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF--- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 181 ngwhGWQWLYLLEGLPSIAAGVLVYTLLddriahakwlsdderalleRNVNAEEAVKSHLSLGAVLANPRVWLMCAIYFS 260
Cdd:COG2814 162 ----GWRWVFLVNAVLALLALLLLLRLL-------------------PESRPAARARLRGSLRELLRRPRLLLLLLLAFL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 261 FVIGLYGVGFWLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRwhLAVPAAMGTVGLVLAVGWAHQT 340
Cdd:COG2814 219 LGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR--LLLIGLLLLALGLLLLALAGSL 296
|
330 340
....*....|....*....|....
gi 848355002 341 GLAIAALTLATMGILTAIPLFWSL 364
Cdd:COG2814 297 WLLLLALFLLGFGFGLLFPLLQAL 320
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
51-417 |
6.73e-20 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 91.09 E-value: 6.73e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 51 QMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAG 130
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 131 FFPGVILYLTYWYPaHRRGRMTTVFMTAVALSGVVGGPISGYILKAFdglngwhGWQWLYLLEGLPSIAAGVLvytlldd 210
Cdd:COG2807 123 GNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL-------GWRGALAVWALLALLALLL------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 211 riahakWLsdderALLERNVNAEEAVKSHLSLGAVLANPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATGVaDPLTIGLL 290
Cdd:COG2807 188 ------WL-----PLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGL-SAATAGLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 291 STVPYALAVLAMIAIARSSDRTRERRWHLAVPAAMGTVGLVLAvgWAHQTGLAIAALTLATMGILTAIPLFWSLPTAFLG 370
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGL--LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRAR 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 848355002 371 GTAAAAGIA-MINSIGNLAGFLGPYLMGLFKQVTASNDAGLYMMAGCM 417
Cdd:COG2807 334 TPAEAAALSgMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALA 381
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-398 |
5.39e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 82.24 E-value: 5.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 53 AGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAGFF 132
Cdd:cd17325 23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 133 PGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILkafdglnGWHGWQWLYLLEGLPSIAAGVLVYTLLDDRI 212
Cdd:cd17325 103 PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA-------DALGYRAPFLVCAALALLALVLALLLLPEPR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 213 AhakwlsdderallERNVNAEEAVKSHLSLGAVLANPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATGVADPLTIGLLST 292
Cdd:cd17325 176 P-------------PPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 293 VPYALAVLAMIAIARSSDRTRERRwhlavPAAMGTVGLVLAVG-WAHQTGLAIAALTLATMGILTAI--PLFWSLPTAFL 369
Cdd:cd17325 243 AQGLASALSQPPAGKLSDRIGRKP-----LILIGLLLSAVALLlLPLATSFWLLLLLLALLGLGLGLvfPATLALLADIV 317
|
330 340
....*....|....*....|....*....
gi 848355002 370 GGTAAAAGIAMINSIGNLAGFLGPYLMGL 398
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGF 346
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
35-403 |
1.38e-15 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 77.80 E-value: 1.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 35 YLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAVSALTMFVTTP 114
Cdd:TIGR00881 4 YAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 115 TAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAFdglngwHGWQWLYLLEG 194
Cdd:TIGR00881 84 WVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAEL------YSWHWVFIVPG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 195 LPSIAAGVLVYTLLDDRIAHAKWLSDDERALLERNVNAEEAVKSHLSLGA----VLANPRVWLMCAIYFSFVIGLYGVGF 270
Cdd:TIGR00881 158 IIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIflqyVLLNKVLWYISLGYVFVYVVRTGILD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 271 WLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRWHLAVPAAMGTVGLVLAVGWAHQTG---LAIAAL 347
Cdd:TIGR00881 238 WSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAAnplMDLICL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 848355002 348 TLATMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFKQVT 403
Cdd:TIGR00881 318 FALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGF 373
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
51-399 |
4.12e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 67.19 E-value: 4.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 51 QMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAG 130
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 131 FFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAFdglngwhGWQWLYLLEGLPSIAAGVLVYTLLDD 210
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-------GWRAAFLAIAVLALLAALLLWRLLPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 211 RIAHAKWLSDDERALLernvnaeeavkshlslgAVLANPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATGVADPLTIGLL 290
Cdd:cd17324 177 LPPKKPGSLGLLSSLL-----------------LLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 291 STVPYALAVLAMIAIARSSDRTRERRwhLAVPAAMGTVGLVLAVGWAHQTGLAIAALTLATMGILTAIPLFWSLpTAFLG 370
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRGGRRA--LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR-VLRLA 316
|
330 340
....*....|....*....|....*....
gi 848355002 371 GTAAAAGIAMINSIGNLAGFLGPYLMGLF 399
Cdd:cd17324 317 PEARGLASSLYLAAYNLGGALGAALGGLV 345
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
28-416 |
8.68e-12 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 66.04 E-value: 8.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 28 MPLLLFCYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAVSAL 107
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 108 TMFVTTPT--AFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKafdglngWHG 185
Cdd:cd17380 81 TPLLAYSSlpLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE-------YYG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 186 WQWLYLLEGLPSIAAGVLVYTLLddriahakwlsdderallernvnaeeavkshlslgavlanPRVWLMCAIYFSFVIGL 265
Cdd:cd17380 154 WPSVFYFFGLLGLLWALVWLIYL----------------------------------------PPVWAIIVAHFCMNWGF 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 266 YGVGFWLPTLIRATGVADPlTIGLLSTVPYALAVLAMIAIARSSDRTRERRWHLA-VPAAMGTVGLV------LAVGWAH 338
Cdd:cd17380 194 YILLSWLPTYFHEVLVPLA-KGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTsVRKLMQSIGFLgpalflLLLSHTD 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 848355002 339 QTGLAIAALTLAtMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFKQVTASNDAGLYMMAGC 416
Cdd:cd17380 273 SFSLALLCMSVA-LGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVV 349
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
87-416 |
1.04e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 65.70 E-value: 1.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 87 RIGARVWIARIMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALsGVVG 166
Cdd:cd17316 62 RIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAL-GALL 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 167 GPISGYILKAFdgLNGWHGWQWLYLLEGLPSiaagvlvytllddriahakwlsdderallernvnaeeavkshlsLGAVL 246
Cdd:cd17316 141 AALVASLLIPL--LSGDWGWRILFLIGALPA--------------------------------------------LLALL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 247 ANPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRWHLAVPAAMG 326
Cdd:cd17316 175 LRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 327 TVGLVLAVGWAHQTGLAIAALTLATMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFKQVTASN 406
Cdd:cd17316 255 ILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGT 334
|
330
....*....|
gi 848355002 407 DAGLYMMAGC 416
Cdd:cd17316 335 GVPALILALL 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
51-417 |
1.07e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.95 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 51 QMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAG 130
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 131 FFPGVILYLTYWYPAHRRGRMtTVFMTAVALSGVVGGPISGYILKAFDGLngwhGWQWLYLLEGLPSIAAGVLVYTlldd 210
Cdd:COG0738 113 LDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLILLGLSL----SWHLPYLILAVLLLLLALLFLR---- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 211 riahakwlsddeRALLERNVNAEEAVKSHLSLGAVLANPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATGVADPLTIGLL 290
Cdd:COG0738 184 ------------SKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 291 STVPYALAVLAMIAIARSSDRTRERRWhLAVPAAMGTVGLVLAVgWAHQTGLAIAALTLATMGILTAIPLFWSLpTAFLG 370
Cdd:COG0738 252 LSLFWGGMTIGRFLGGFLLKRFGPVRL-LRLSALLAAVGLLLAL-LAPGPWLALIGLALVGLGLSLMFPTIFSL-ALDGL 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 848355002 371 GTAAAAGIAMINSIGNLAGFLGPYLMGLFKQVTASNdAGLYMMAGCM 417
Cdd:COG0738 329 GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLR-AAFLVPLVCY 374
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
52-417 |
2.41e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 61.87 E-value: 2.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 52 MAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAGF 131
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 132 FPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAFdglngwhGWQWLYLLEGLPSIAAGVLVYTLLDDR 211
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHY-------GWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 212 iahakwlsdderalLERNVNAEEAVKSHLSLGAVLANPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATGVADPLTIGLLS 291
Cdd:cd17475 175 --------------PAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 292 TVPYALAVLAMIAIARSSDR----TRERRWHLAVPAAMGTVGLVLAVGWAHQTGLAIAALTLATMGILTAIPLFWSLPTA 367
Cdd:cd17475 241 AVAQLGGALGRIGLGRVSDRvfggRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 848355002 368 FLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFKQVTASNDAGLYMMAGCM 417
Cdd:cd17475 321 SAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLL 370
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
50-417 |
4.15e-10 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 61.11 E-value: 4.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 50 LQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVW-IARIMVTWGAVSALTMFVTTPTAFYAMRFLLGAAE 128
Cdd:cd17341 23 PVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVfIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 129 AGFFPGvILYLTYWYPAHRRGrmtTVFMTAVALsGVVGGPISGYIL----KAFDGLNGWHGWQWLYLLEGLPSIAAGVLV 204
Cdd:cd17341 103 ANFASG-QPWASFWFPKEKIG---GAAGGIAGA-GNMGVAVSQLLApliaGAIVFDGGFVGWRNAFFVPGILLAIAAVLV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 205 YTLLDDRIAHAKWLSDDERALLernvnaeeavkshlslgAVLANPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATGVADP 284
Cdd:cd17341 178 LLFGDDLPTGKASALEFLKVQL-----------------AVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 285 LTIGLLSTVPYALAVLAMIAIARSSDRTRERRWHLAVPAAMGTVGLVLAVGWAHQTGLAIAALTLATMGILTAIPLFWSL 364
Cdd:cd17341 241 VTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSV 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 848355002 365 P--TAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFKQVTASNDAGLYMMAGCM 417
Cdd:cd17341 321 FrmVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLA 375
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
25-306 |
1.49e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 58.67 E-value: 1.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 25 WRLMPLLLFCYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAV 104
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 105 SALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAFdglngwh 184
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 185 GWQWLYLLEGLPSIAAGVLVYTLLDDRIAHAKWLSDDERALLERNVNAEEAVKSHLSLGAVLANPRVWLMCAIYFSFVIG 264
Cdd:COG0477 166 GWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLAL 245
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 848355002 265 LYGVGFWLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIA 306
Cdd:COG0477 246 LLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLL 287
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
29-284 |
3.08e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 58.40 E-value: 3.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 29 PLLLFCYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGaRVWIARI-MVTWGAVSAL 107
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN-RKWILAVgILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 108 TMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAFDglngwhGWQ 187
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG------GWR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 188 WLYLLEGLPSIAAGVLVYTLLDDRiahakwlsddERALLERNVNAEEAVKSHL-SLGAVLANPRVWLMCAIYFSFVIGLY 266
Cdd:cd17328 155 WAFRVTGVLGVLLAILLLLFVREP----------PRGAAEGGVMAKSTATSFLaDLKALAKNPSFILSTLGFTAVSFVTG 224
|
250
....*....|....*....
gi 848355002 267 GVGFWLPTLI-RATGVADP 284
Cdd:cd17328 225 ALAFWAPTFFlRAFGVGDL 243
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
102-398 |
1.41e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.42 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 102 GAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALsGVVGGPISGyilkafdGLN 181
Cdd:cd17474 75 GIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGL-GIAVGPLLG-------GLL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 182 GWHGWQWLYLLEGLPSIAAGVLVYTLLDDRIAHAKWLSdderallernvnaeeaVKSHLSLGAVLANPRVWLMCAIYFSF 261
Cdd:cd17474 147 AAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSS----------------ATKLRDLKKALRGRGLLTFLVSAFLY 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 262 VIGLYGVGFWLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRWHLAVpAAMGTVGLVLAVGWAHQTG 341
Cdd:cd17474 211 FFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVI-GLLLYALSLLLLGFVPSLA 289
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 848355002 342 LAIAALTLATMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGL 398
Cdd:cd17474 290 LLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGL 346
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
98-417 |
1.51e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 56.04 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 98 MVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYIlkaf 177
Cdd:cd17473 72 LLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL---- 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 178 dGLNGWHGWQWLYLLeglpSIAAGVLVYtllddriahakwlsddeRALLERNVNAEEAVKSHLSLGAVLANPRVWLMCAI 257
Cdd:cd17473 148 -AEIGWRAPFLVYLL----ALPVLILVL-----------------LFLPEPARKSKSAASPGAATAAALPWKRVLPIYFL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 258 YFSFVIGLYGVGFWLPTLIRATGVADPLTIGLLStvpyALAVLAMIAIARSSDRTRER---RWHLAVPAAMGTVGLVLaV 334
Cdd:cd17473 206 AFLAMLLFYVIPIQLPFLLQERGGGSAALIGLAL----AIASLAGAIGALLFGRLKRRlgkRRLLAIGFALMALGFLL-L 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 335 GWAHQTGLAIAALTLATMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFKQVTASNDAGLYMMA 414
Cdd:cd17473 281 ALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILG 360
|
...
gi 848355002 415 GCM 417
Cdd:cd17473 361 VLA 363
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
102-354 |
7.64e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 54.10 E-value: 7.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 102 GAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILkafdgln 181
Cdd:cd17321 72 GLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLL------- 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 182 GWHGWQWLYLLeglpSIAAGVLvytllddriahakwlsdderallernvnaeeavkshlslgAVLANPRVWLMCAIYFSF 261
Cdd:cd17321 145 ELFGWRWIFLI----NVPIGLV----------------------------------------ALLLARTFSGAVLAAFLL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 262 VIGLYGVGFWLPTLIRATGVADPLTIGLLsTVPYALAVLAMIAIA-RSSDRTRERRWhLAVPAAMGTVGLVLAVGWAHQT 340
Cdd:cd17321 181 GAALGGLLFLLPLYLQGVLGYSPLQAGLA-LLPLALAMLVAAPLAgRLADRFGPRLV-LVAGLLLTAVGLLLLALLGADS 258
|
250
....*....|....
gi 848355002 341 GLAIAALTLATMGI 354
Cdd:cd17321 259 SVWLLLPGLVLLGL 272
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
25-397 |
3.36e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 51.97 E-value: 3.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 25 WRLMPLLLFCYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAV 104
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 105 SALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAFdglngwh 184
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 185 GWQWLYLLEGLPSIAAGVLVYTLLDDRIAHAKwLSDDERALLERNVNAEEAVKSHLSLGAVL-ANPRVW----------- 252
Cdd:TIGR00895 169 GWRSLFYVGGIAPLLLLLLLMRFLPESIDFLV-SKRPETVRRIVNAIAPQMQAEAQSALPEQkSTQGTKrsvfkalfqgk 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 253 ------LMCAIYFSFVIGLYGVGFWLPTLIRATGVADPLTIGLLSTVpYALAVLAMIAIARSSDRTRERrwHLAVPAAMG 326
Cdd:TIGR00895 248 taritvLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALF-NFGGVIGSIIFGWLADRLGPR--VTALLLLLG 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 848355002 327 TVGLVLAVGWAHQTGLAIAALTLATMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMG 397
Cdd:TIGR00895 325 AVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAG 395
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
146-364 |
4.32e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.83 E-value: 4.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 146 HRRGRMTTVFMTAVALSGVVGGPISGYILKAFDGlNGWHGWQWLYLLEGLPSIAAGVLVYTLLDdriahakwlsdderal 225
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGG-DAALGYRLTALIFAVLGLLAFLLTFFGTK---------------- 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 226 lERNVNAEEAVKSHLSLGAVLANPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAI 305
Cdd:COG2211 206 -ERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLW 284
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 848355002 306 ARSSDRTRERRWHLAVPAAMGTVGLVLAVGWAHQTGLAIAALTLATMGILTAIPLFWSL 364
Cdd:COG2211 285 PRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAM 343
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
84-417 |
5.79e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 51.50 E-value: 5.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 84 ILHRIGARVWIARIMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVI-LYLTYWYPAHRRGRMTTVFMTAVALS 162
Cdd:cd17355 61 LLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 163 GVVGGPISGyilkafdGLNGWHGWQWLYLLEGLPSIAAGVLVYTLLDDRIAHAKwlsdderalLERNVNAEEAVKSHlSL 242
Cdd:cd17355 141 SLVFLPLGA-------ALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLA---------LRAYDDASPASPGS-TL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 243 GAVLANPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATGVADPLTIGLLSTVpYALAVLAMIAIARSSDRTrERRWHLAVP 322
Cdd:cd17355 204 KEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALI-GLFNIVGRLLSGWLGDRY-SPRRLLAAS 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 323 AAMGTVGLVLAVGWAHQTGLAIAALTLATMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFKQV 402
Cdd:cd17355 282 YALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDR 361
|
330
....*....|....*
gi 848355002 403 TASNDAGLYMMAGCM 417
Cdd:cd17355 362 TGSYTAAWALAVALG 376
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
25-416 |
1.65e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.96 E-value: 1.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 25 WRLMPLLLFCYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAV 104
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 105 SALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILkafdglnGWH 184
Cdd:cd17312 82 NIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLA-------SYY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 185 GWQWLYLLEGLPSIAAGVLVYTLLDDRiahakwlsdderallernvnaeeavkshlslgavlaNPRVWLMCAIYFSFVIG 264
Cdd:cd17312 155 GWRAAFLVPGIVGLVVAIILFFFLRDS------------------------------------PPYVWVLSLAYAFVYIV 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 265 LYGVGFWLPTLIRATGVADPLTIGLLSTVpYALAVLA-MIAIARSSDRTRERRWHLAVPAAMGTVGLVLAVGWAHQTGLA 343
Cdd:cd17312 199 RYACLDWGPLYLYEVKGYSLIDAGWFSSL-YEVGGIAgTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKL 277
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 848355002 344 IAALTLATMGILTAIP--LFWSL-PTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFKQVTASNDAGLYMMAGC 416
Cdd:cd17312 278 LSIVLLFLIGFFVGGPinLIGGAaAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAA 353
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
30-399 |
4.57e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 48.38 E-value: 4.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 30 LLLFCYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIF----------------------EVPSNLILHR 87
Cdd:cd17318 3 LLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDTLPVEAPEfdwsektqgiilssffygyiltQIPGGYLAEK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 88 IGARvwiarIMVTWGAVSA--LTMFvtTP-------TAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTA 158
Cdd:cd17318 83 YGAK-----RVLGYSILITalLTLL--TPlaarggyGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 159 VALSGVVGGPISGYILKafdglngWHGWQWLYLLEGLPSIAAGVLVYTLLddriahakwlsdderallernvnaeeavks 238
Cdd:cd17318 156 SQFGTVIAMPLSGFLCE-------SLGWPSIFYIFGGLGLLWCLLWFFLV------------------------------ 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 239 hlslgavlanPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRW- 317
Cdd:cd17318 199 ----------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIl 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 318 -HLAVPAAMGTVGLV------LAVGW-AHQTGLAIAALTLAtMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAG 389
Cdd:cd17318 269 sTTTVRKLFTSIGFLgpgvflIALGYlGSNATLAVVFLTLS-VGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAG 347
|
410
....*....|
gi 848355002 390 FLGPYLMGLF 399
Cdd:cd17318 348 IISPLIVGAI 357
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
26-209 |
3.11e-05 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 45.86 E-value: 3.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 26 RLMPLLLFCYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAVS 105
Cdd:cd17488 3 HILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIIN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 106 ALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKafdglngWHG 185
Cdd:cd17488 83 ILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAAL-------TYG 155
|
170 180
....*....|....*....|....*
gi 848355002 186 WQWLYLLEGLPSIAAG-VLVYTLLD 209
Cdd:cd17488 156 WRAGMYVPGIIAILMGiVLCWRLRD 180
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
87-356 |
4.07e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 45.27 E-value: 4.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 87 RIGARVWIARIMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVG 166
Cdd:cd17365 60 RFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 167 GPISGYILKAFdglngwhGWQWLYLLEGLPSIAAGVLVYTLLddriahakwlsdderallernvnaeeavkshlslgavl 246
Cdd:cd17365 140 GFLAAALIPAF-------GWRSVFLLGGVPPLILLPLLRGTL-------------------------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 247 anprvwLMCAIYFSFVIGLYGVGFWLPTLIRATGvADPLTIGLLSTVPYALAVLAMIAIARSSDRtreRRWHLAVPAAMG 326
Cdd:cd17365 175 ------LLWVTFFMGLLLVYLLNSWLPKLMVEAG-YSLSQALTITLLLNIGGVIGSLLLGWLADR---FGPKRVLALFFA 244
|
250 260 270
....*....|....*....|....*....|
gi 848355002 327 TVGLVLAVGWAHQTGLAIAALTLATMGILT 356
Cdd:cd17365 245 LGAVSLALLGVSPASLVLLYVLVFLAGACV 274
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
119-398 |
6.40e-05 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 45.12 E-value: 6.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 119 AMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAfdglngWHGWQWLYLLEGLPSI 198
Cdd:TIGR00894 136 FCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCES------WGGWPMIFYVFGIVGC 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 199 AAGVLVYTLLDDRIAHAKWLSDDERALLERNVNAEEAVKS-HLSLGAVLANPRVWLMCAIYFSFVIGLYGVGFWLPTLIR 277
Cdd:TIGR00894 210 AWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQKGSTRqSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFIS 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 278 ATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRWHLAVPA-----AMGTVGLVLAVGWAHQTG----LAIAALT 348
Cdd:TIGR00894 290 WVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSLTAArkifnGIGGLGPGIFAYALPYLSaafyLTIIILT 369
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 848355002 349 LA-------TMGILTAIPlfwslptaflggTAAAAGIAMINSIGNLAGFLGPYLMGL 398
Cdd:TIGR00894 370 LAnavssgpLAGVLINSL------------DLAPRFLGFIKGITGLPGFIGGLIAST 414
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
87-417 |
7.18e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.91 E-value: 7.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 87 RIGARVWIARIMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVG 166
Cdd:cd17329 61 RFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 167 GPISGYILKafdglngwHGWQWLYLLEGLPSIAAGVLVYTLLDDRIAHAKwlsdderallernvnAEEAVKSHLSLGAVL 246
Cdd:cd17329 141 PLLGGLLLL--------YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRR---------------AAEKTEILRGYKIVL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 247 ANPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRWhLAVPAAMG 326
Cdd:cd17329 198 RDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKI-LMIGILLF 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 327 TVGLVlAVGWAHQTGLAIAALTLATMGILTAIPLFWSLPTAFLGGTAAAAGIAMINSIGNLAGFLGPYLMGLFkqVTASN 406
Cdd:cd17329 277 AIGFA-VLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLL--LDLLG 353
|
330
....*....|.
gi 848355002 407 DAGLYMMAGCM 417
Cdd:cd17329 354 PGLPWLILAAL 364
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
121-354 |
2.21e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 43.33 E-value: 2.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 121 RFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAFdglngwhGWQWLYLLEgLPSIAA 200
Cdd:cd17503 91 RILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNL-------SWRWIFYIN-LPIGIL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 201 GVLVYTLLDDRiahakwlsdderallernvnaeeavkshlslgaVLANPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATG 280
Cdd:cd17503 163 ALLLAPLLDLR---------------------------------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVL 209
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 848355002 281 VADPLTIGLLsTVPYALAVLAMIAIARSSDRTRERRWHLAVPAAMGTVGLVLAVGWAHQTGLAIAALTLATMGI 354
Cdd:cd17503 210 GYSAFESGLV-LAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGL 282
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
146-417 |
2.43e-04 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 42.95 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 146 HRRGRMTTVFMTAVALSGVVGGPISGYILKAFDGlngwhGWQWLYLLEGLPSIAAGVLvytllddriahakWLsdderaL 225
Cdd:cd17339 117 RRVGLMTGLYTTSMNLGAALASGLSVPLAQALGG-----GWRGALAIWALPALLALLI-------------WL------P 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 226 LERNVNAEEAVKSHLSLGAVLANPRVWLMcAIYFSFVIGLYGVGF-WLPTLIRATGVaDPLTIGLLSTVPYALAVLAMIA 304
Cdd:cd17339 173 QLRRRKRAAAAAAPLTKISVWRSPLAWQV-TLFMGLQSLLFYTLMaWLPTILIDAGL-SAATAGWLLSLFQLVGIPASLL 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 305 IARSSDRTRERRWHLAVPAAMGTVGLVLAVGWAHQTGLAIAALTLATMGILTAIPL-FWSLPTAFLGGTAAAAGiaMINS 383
Cdd:cd17339 251 VPILATRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVLLGLGGGAAFSLALtLISLRSSDPAEAAALSG--MAQS 328
|
250 260 270
....*....|....*....|....*....|....
gi 848355002 384 IGNLAGFLGPYLMGLFKQVTASNDAGLYMMAGCM 417
Cdd:cd17339 329 VGYLLAALGPLLFGVLHDLTGSWTAPLVLLLALT 362
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
103-207 |
3.66e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.55 E-value: 3.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 103 AVSAL-TMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVaLSGVVGGPISGYILKAF--DG 179
Cdd:cd17359 77 FISALgSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMI-VFGQLLAYIVNYLIANAggAD 155
|
90 100
....*....|....*....|....*...
gi 848355002 180 LNGWHGWQWLYLLEGLPSIAAGVLVYTL 207
Cdd:cd17359 156 WLGAEGWRWMLGLEAIPAILFLLGMLFI 183
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
97-366 |
3.78e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 42.64 E-value: 3.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 97 IMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALsGVVGGPISGYILKA 176
Cdd:pfam00083 85 LFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITF-GILLAYIFGLGLNK 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 177 FDGLNGWHGWQWLYLLEGLPSIAAGVLV-----YTLLDDRIAHAK----WLS---------DDERALLERNVNAEEAvkS 238
Cdd:pfam00083 164 TSNSDGWRIPLGLQLVPALLLIIGLLFLpesprWLVEKGRLEEARevlaKLRgvpdvdrelDEIKDSLEAGQEAEKA--S 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 239 HLSLGAVLANPRVWLMCAIYFSF--VIGLYGVGFWLPTLIRATGVADPLTIgllSTVPYALAVLAMIAIARSSDRTRERR 316
Cdd:pfam00083 242 WKELFSTKTRRQRLLIGVMLQIFqqLTGINAIFYYSTTIFENLGLSDSFLV---TIIVGVVNFVFTFIAIFLVDRFGRRP 318
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 848355002 317 WHLAVPAAM-------GTVGLVLAVGWAHQTGLAIAALTLATMGILTAI-PLFWSLPT 366
Cdd:pfam00083 319 LLLLGAAGMaicfvilGIVALLGVSKSDWAGIVAIVFIALFIAFFAMGWgPVPWVIVS 376
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
33-361 |
4.45e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 42.23 E-value: 4.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 33 FCYLVSYLDRVNVGFAKLQMAGDLGLSDA-----------AYGLgagifffgyfifevpSNLILHRIGARVWIARIMVTW 101
Cdd:cd17345 10 IGYAGYYLVRNNFSLAQPYLIEQYGLSKTeigligsalsiAYGL---------------SKFVMGNLSDRSNPKRFLAIG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 102 GAVSALTMFV--------TTPTAFYAMRFLLGAAE-AGFFPGVILyLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGY 172
Cdd:cd17345 75 LILSAIINILigfvpsatSSVGLMFILLFLNGWFQgMGWPPSGRT-MVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 173 ILKAFdglnGWHGWQWLYLLEGLPSIAAGVLVYTLLDDRIAHAKWLSDDERALLERNVNAEEAVKSHLSLGA-----VLA 247
Cdd:cd17345 154 GLAIF----GDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQELSAWEifvkyVLK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 248 NPRVWLmCAIYFSFVIGL-YGVGFWLPT-LIRATGVADPLTIGLLSTVPYAlAVLAMIAIARSSDRTRERRWHLAVPAAM 325
Cdd:cd17345 230 NKLLWY-IAIANVFVYLVrYGILDWAPTyLSEVKGFSKAQAMWAFSLFEWA-AIPGTLLAGWLSDKLFKGRRAPTGIIFM 307
|
330 340 350
....*....|....*....|....*....|....*.
gi 848355002 326 GTVGLVLAVGWaHQTGLAIAALTLATMGILTAIPLF 361
Cdd:cd17345 308 ILVIVALIVYW-LAPNVLVDLIALIALGFLIYGPVM 342
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
55-359 |
5.47e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.81 E-value: 5.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 55 DLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPG 134
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 135 VILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYILKAFdglngwhGWQWLYLLEGLPSIAAGVLVYTLLDdriah 214
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL-------GFAVLFIVAAVLALLALLLVFLVKD----- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 215 akwlsdderalleRNVNAEEAVKSHLSLGAVLANPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATGVADpltIGLLSTVp 294
Cdd:cd17489 173 -------------PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN---AGLFFTV- 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 848355002 295 YALAVLAMIAIA-RSSDRTRERRwhLAVPAAMGTVGLVLAVGWAHQTGLAIAALTLATMGILTAIP 359
Cdd:cd17489 236 YAIALLLSRPFSgKLSDRKGPKT--VIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFP 299
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
81-238 |
9.91e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 41.09 E-value: 9.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 81 SNLILHRIGaRVWIARIMVTWGAVSALTMFVTTPTAFYAM----RFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFM 156
Cdd:cd17357 69 SAFLANRFG-RKNGLLISNALLVVSSLLMFLSKSAKSPELlifgRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQ 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 157 TAVALSGVVGGPISgyiLKAFDGlnGWHGWQWLYLLEGLPSIAAGVLVYtllddriahakWLSDDERALLERNVNAEEAV 236
Cdd:cd17357 148 IGVTLGILLGQVFG---LPSVLG--TETLWPYLLFFPGIPALLQLAALP-----------FFPESPKFLLISKGDEEEAE 211
|
..
gi 848355002 237 KS 238
Cdd:cd17357 212 KS 213
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
87-205 |
1.58e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 40.64 E-value: 1.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 87 RIGARVWIARIMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVG 166
Cdd:cd17325 261 RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
|
90 100 110
....*....|....*....|....*....|....*....
gi 848355002 167 GPISGYILKAFdglngwhGWQWLYLLEGLPSIAAGVLVY 205
Cdd:cd17325 341 PLLGGFLYDAF-------GFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
257-354 |
1.95e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 40.30 E-value: 1.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 257 IYFSFVIglygvgFWlPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRWHLAVPAAMGTVGLV-LAVG 335
Cdd:cd06179 277 IFYSLNI------FW-PQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKWQLVAGFVLFTAFLAlLALI 349
|
90
....*....|....*....
gi 848355002 336 WAHQTGLAIAALTLATMGI 354
Cdd:cd06179 350 TPDNKALAIAFSVLAGIGI 368
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
84-360 |
2.60e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.85 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 84 ILHRIGARVWIARIMVTWGAVSALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSG 163
Cdd:cd17477 54 LIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGF 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 164 VVGGPISGYIlkafdglnGWHGWQWLYLLEGLPSIAAGVLvytllddriahakwlsdderaLLERNVNAEEAVKSHLSLG 243
Cdd:cd17477 134 ALGPLLLALV--------GTAGALPFLIAAVLLLLALVPL---------------------LLTRRAAPEIEEAESISLR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 244 AVLANPRVWLMCAIYFSFVIG-------LYGVGFWLPTLIratgvadpltIGLLSTVPYALAVLAMIAIARSSDRTrERR 316
Cdd:cd17477 185 RLLRIAPLALLGAFVAGFLEGafysllpLYGLRLGLSVAQ----------AALLLAAFVLGGLLLQWPLGWLADRF-DRR 253
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 848355002 317 WHLAVPAAMGTVGLVLAVGWAHQTGLAIAALTLATMGILTAIPL 360
Cdd:cd17477 254 RVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTL 297
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
17-259 |
2.64e-03 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 40.08 E-value: 2.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 17 EAAYRKvaWR--LMPLLLFCYLVSYLDRVNVGFAKLQMAGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWI 94
Cdd:PRK11663 14 DARYRY--WRrhILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFM 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 95 ARIMVTWGAVSALTMFVTTPTAFyAMRFLLGAAEAGF-FPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVGGPISGYI 173
Cdd:PRK11663 92 GIGLIATGIINILFGFSSSLWAF-ALLWVLNAFFQGWgWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 174 LKAFdglngwhGWQWLYLLEGLPSIAAGVLVYTLLDDR------IAHAKWLSDDERALLE---RNVNAEEAVKSHlslga 244
Cdd:PRK11663 171 ALHY-------GWRYGMMIAGIIAIVVGLFLCWRLRDKpqamglPSVGEWRHDALELAQQqegAGLSRKEILTKY----- 238
|
250
....*....|....*
gi 848355002 245 VLANPRVWLMCAIYF 259
Cdd:PRK11663 239 VLLNPYIWLLSFSYV 253
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
88-358 |
4.55e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.21 E-value: 4.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 88 IGARVWIARIMVTWGAVS-----ALTMFVTTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALS 162
Cdd:cd06180 56 FLRRRGRARRLIRGGLLLtvlllAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 163 GVVGGPISGYILKAfdGLNGWHGWQWLYLLEGLPSIAAGVLVYTLLDDriahakwlsdderallernvnaeeAVKSHLSL 242
Cdd:cd06180 136 IALSGLLVPAGLGG--GLSWRAGWLALALLSAVLLLLSFLLLRRGPSA------------------------PTEASAAE 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 243 GAVLANPRVWLMCAIYFSFVIGLYGVGFWLPTLIRATGvADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRWhLAVP 322
Cdd:cd06180 190 SAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETG-AGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRA-LAAN 267
|
250 260 270
....*....|....*....|....*....|....*...
gi 848355002 323 AAMGTVGLVLAVGWAHQTGLAIAALT--LATMGILTAI 358
Cdd:cd06180 268 LLVQAVGVLLPLLSPGPAGLVLSAVLfgGTFMAITALV 305
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
96-361 |
4.59e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.14 E-value: 4.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 96 RIMVTWGAVSALTMFV---------TTPTAFYAMRFLLGAAEAGFFPGVILYLTYWYPAHRRGRMTTVFMTAVALSGVVG 166
Cdd:cd06173 65 RLLILADLLRALLAAVlallallgsLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 167 GPISGYILkafdglnGWHGWQWLYLLEGLPSIAAGVLVYTLlddRIAHAKWLSDDERALLERNVNAEEAVKSHLSLgavl 246
Cdd:cd06173 145 PALGGLLV-------ALLGPGGAFAINALSFLLSALLLLFI---RRPPPAAPGESSSLLLRDLREGLRYLRRSPLL---- 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 247 anpRVWLMCAIYFSFVIGLYGVGfwLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERRwhLAVPAAMG 326
Cdd:cd06173 211 ---RLLLLALALFALLGGALTVL--LPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR--LLLIGALL 283
|
250 260 270
....*....|....*....|....*....|....*
gi 848355002 327 TVGLVLAVGWAHQTGLAIAALTLATMGILTAIPLF 361
Cdd:cd06173 284 LGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
33-354 |
6.64e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.44 E-value: 6.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 33 FCYLVSYLDRVNVGFAKLQM-AGDLGLSDAAYGLGAGIFFFGYFIFEVPSNLILHRIGARVWIARIMVTWGAVSALTMFV 111
Cdd:TIGR00886 8 FGFFLSFLVWFAFSPLAVFLiKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 112 TTP-TAFYAMRFLLGAAEAGFFPGvILYLTYWYPAHRRGrmttvfmTAVALSG-----------VVGGPISGYILKAfDG 179
Cdd:TIGR00886 88 VQSySVLLLIRLFIGIAGGSFASC-MPWISFFFPKKIQG-------TALGLAAgwgnmgggvaqFVMPPIIGSLIFG-GG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 180 LNGWHGWQW-LYLLEGLPSIAAGVLVYTLLDDriahakWLSDDeraLLERNVNAEEAVKshlslgaVLANPRVWLMCAIY 258
Cdd:TIGR00886 159 QPAHLAWGWaFVIVPAGILLLPALLIFFVGAD------TPPGK---PATGKLSFKEALK-------VFGNRHTWILALLY 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 848355002 259 FSFVIGLYGVGFWLPTLIRATGVADPLTIGLLSTVPYALAVLAMIAIARSSDRTRERR--WHLAVPAAMGtvglVLAVGW 336
Cdd:TIGR00886 223 SVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARklLMNFLGVAMG----AFLVVL 298
|
330
....*....|....*...
gi 848355002 337 AHQTGLAIAALTLATMGI 354
Cdd:TIGR00886 299 GLVSDGSLAAFIVLFVAL 316
|
|
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