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Conserved domains on  [gi|84781762|ref|NP_001033928|]
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P2X purinoceptor 7 isoform c [Mus musculus]

Protein Classification

P2X purinoceptor( domain architecture ID 10467639)

P2X purinoceptor consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P2X_receptor pfam00864
ATP P2X receptor;
11-390 0e+00

ATP P2X receptor;


:

Pssm-ID: 459968  Cd Length: 362  Bit Score: 543.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762    11 LQYETNKVTRIQSTNYGTVKWVLHMIVFSY-ISFALVSDKLYQRKEPVISSVHTKVKGIAEVTenvteggVTKLGHSIFD 89
Cdd:pfam00864   1 FDYETPKVVVIRSKKVGLIYRLVQLLILGYiIGWVFVYEKGYQEKDTVVSSVTTKVKGVAVTN-------VSDYGIRVWD 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762    90 TADYTFPLQG-NSFFVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWC 168
Cdd:pfam00864  74 VADYVIPPQGeNVFFVMTNLIVTPNQTQGTCPESPDGKPNCTSDQDCGAGEGKPVGNGIQTGRCVPFNWTTKTCEIFGWC 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762   169 PTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGS----CTFHKTWDPQCSIFRLGDIFQEAGENFTE 244
Cdd:pfam00864 154 PVELDTAPPFPPLLKNAENFTVFIKNSIRFPKFNFSRRNILPQYDKTylktCTYHPLTDPYCPIFRLGDIVAEAGENFSE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762   245 VAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYKE-NNVEKRTLIKAFGIRFDILVFG 323
Cdd:pfam00864 234 LANKGGVIGIKINWDCDLDSDRSHCNPKYSFRRLDGKNFNNAVSPGYNFRFAKYYKEkNGVERRTLIKAYGIRFDIIVFG 313
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84781762   324 TGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSSAfcrsgvypyckccepctvNEYYYRKKCES 390
Cdd:pfam00864 314 KAGKFSIIPTIINIGSGLALLGVATVLCDLILLYFLKK------------------REFYYDKKFEE 362
P2RX7_C super family cl48632
P2X purinoreceptor 7 intracellular domain; This entry represents the intracellular domain ...
400-430 7.40e-12

P2X purinoreceptor 7 intracellular domain; This entry represents the intracellular domain found at the the C-terminus of P2X purinoreceptor 7 protein.


The actual alignment was detected with superfamily member pfam20478:

Pssm-ID: 466627  Cd Length: 185  Bit Score: 63.75  E-value: 7.40e-12
                          10        20        30
                  ....*....|....*....|....*....|.
gi 84781762   400 YVSFVDEPHIRMVDQQlLGKSLQVVKGQEVP 430
Cdd:pfam20478   1 YVSFVDEPHIRLVKKS-LKKSLQDVKGESVP 30
 
Name Accession Description Interval E-value
P2X_receptor pfam00864
ATP P2X receptor;
11-390 0e+00

ATP P2X receptor;


Pssm-ID: 459968  Cd Length: 362  Bit Score: 543.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762    11 LQYETNKVTRIQSTNYGTVKWVLHMIVFSY-ISFALVSDKLYQRKEPVISSVHTKVKGIAEVTenvteggVTKLGHSIFD 89
Cdd:pfam00864   1 FDYETPKVVVIRSKKVGLIYRLVQLLILGYiIGWVFVYEKGYQEKDTVVSSVTTKVKGVAVTN-------VSDYGIRVWD 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762    90 TADYTFPLQG-NSFFVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWC 168
Cdd:pfam00864  74 VADYVIPPQGeNVFFVMTNLIVTPNQTQGTCPESPDGKPNCTSDQDCGAGEGKPVGNGIQTGRCVPFNWTTKTCEIFGWC 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762   169 PTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGS----CTFHKTWDPQCSIFRLGDIFQEAGENFTE 244
Cdd:pfam00864 154 PVELDTAPPFPPLLKNAENFTVFIKNSIRFPKFNFSRRNILPQYDKTylktCTYHPLTDPYCPIFRLGDIVAEAGENFSE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762   245 VAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYKE-NNVEKRTLIKAFGIRFDILVFG 323
Cdd:pfam00864 234 LANKGGVIGIKINWDCDLDSDRSHCNPKYSFRRLDGKNFNNAVSPGYNFRFAKYYKEkNGVERRTLIKAYGIRFDIIVFG 313
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84781762   324 TGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSSAfcrsgvypyckccepctvNEYYYRKKCES 390
Cdd:pfam00864 314 KAGKFSIIPTIINIGSGLALLGVATVLCDLILLYFLKK------------------REFYYDKKFEE 362
P2X TIGR00863
cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC ...
3-355 1.55e-135

cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273307  Cd Length: 372  Bit Score: 393.71  E-value: 1.55e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762     3 ACCS--WNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSY-ISFALVSDKLYQRKEP-VISSVHTKVKGIAevtenVTEg 78
Cdd:TIGR00863   4 RLAAglSSFFFDYKTPKYVLVRNKKVGVIYRLVQLLILVYvIGWVFLAEKGYQESDTsPQSSVITKVKGVA-----VTQ- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762    79 gVTKLGHSIFDTADYTFPLQG-NSFFVMTNYVKSEGQVQTLCPEYPRRG-AQCSSDRRCKKGWMDPQSKGIQTGRCVPYD 156
Cdd:TIGR00863  78 -TSELGNRVWDVADYVKPPQGeNVFFVMTNFIVTPNQTQGRCPEHPSVPlAICWSDSDCTAGEAGTHGNGIKTGRCVPFN 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762   157 KTRKTCEVSAWCPTEEeKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNG----SCTFHKTWDPQCSIFRLG 232
Cdd:TIGR00863 157 GTVKTCEIFAWCPVEV-DTVPSPPLLKEAENFTLFIKNSIRFPKFNFSKRNILETWDAtylkTCLFDPDSDPYCPIFRLG 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762   233 DIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESfvPGYNFRYAKYYKENN-VEKRTLIK 311
Cdd:TIGR00863 236 DIVEEAGQDFQDLALKGGVVGITINWDCDLDKAASHCNPKYSFRRLDNKEKNVS--PGYNFRFAKYYRDNAgVETRTLLK 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 84781762   312 AFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLI 355
Cdd:TIGR00863 314 AYGIRFDILVTGKAGKFDIIPTMITIGSGLASLGVGTFLCDLIL 357
P2RX7_C pfam20478
P2X purinoreceptor 7 intracellular domain; This entry represents the intracellular domain ...
400-430 7.40e-12

P2X purinoreceptor 7 intracellular domain; This entry represents the intracellular domain found at the the C-terminus of P2X purinoreceptor 7 protein.


Pssm-ID: 466627  Cd Length: 185  Bit Score: 63.75  E-value: 7.40e-12
                          10        20        30
                  ....*....|....*....|....*....|.
gi 84781762   400 YVSFVDEPHIRMVDQQlLGKSLQVVKGQEVP 430
Cdd:pfam20478   1 YVSFVDEPHIRLVKKS-LKKSLQDVKGESVP 30
 
Name Accession Description Interval E-value
P2X_receptor pfam00864
ATP P2X receptor;
11-390 0e+00

ATP P2X receptor;


Pssm-ID: 459968  Cd Length: 362  Bit Score: 543.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762    11 LQYETNKVTRIQSTNYGTVKWVLHMIVFSY-ISFALVSDKLYQRKEPVISSVHTKVKGIAEVTenvteggVTKLGHSIFD 89
Cdd:pfam00864   1 FDYETPKVVVIRSKKVGLIYRLVQLLILGYiIGWVFVYEKGYQEKDTVVSSVTTKVKGVAVTN-------VSDYGIRVWD 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762    90 TADYTFPLQG-NSFFVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWC 168
Cdd:pfam00864  74 VADYVIPPQGeNVFFVMTNLIVTPNQTQGTCPESPDGKPNCTSDQDCGAGEGKPVGNGIQTGRCVPFNWTTKTCEIFGWC 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762   169 PTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGS----CTFHKTWDPQCSIFRLGDIFQEAGENFTE 244
Cdd:pfam00864 154 PVELDTAPPFPPLLKNAENFTVFIKNSIRFPKFNFSRRNILPQYDKTylktCTYHPLTDPYCPIFRLGDIVAEAGENFSE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762   245 VAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYKE-NNVEKRTLIKAFGIRFDILVFG 323
Cdd:pfam00864 234 LANKGGVIGIKINWDCDLDSDRSHCNPKYSFRRLDGKNFNNAVSPGYNFRFAKYYKEkNGVERRTLIKAYGIRFDIIVFG 313
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 84781762   324 TGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSSAfcrsgvypyckccepctvNEYYYRKKCES 390
Cdd:pfam00864 314 KAGKFSIIPTIINIGSGLALLGVATVLCDLILLYFLKK------------------REFYYDKKFEE 362
P2X TIGR00863
cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC ...
3-355 1.55e-135

cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273307  Cd Length: 372  Bit Score: 393.71  E-value: 1.55e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762     3 ACCS--WNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSY-ISFALVSDKLYQRKEP-VISSVHTKVKGIAevtenVTEg 78
Cdd:TIGR00863   4 RLAAglSSFFFDYKTPKYVLVRNKKVGVIYRLVQLLILVYvIGWVFLAEKGYQESDTsPQSSVITKVKGVA-----VTQ- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762    79 gVTKLGHSIFDTADYTFPLQG-NSFFVMTNYVKSEGQVQTLCPEYPRRG-AQCSSDRRCKKGWMDPQSKGIQTGRCVPYD 156
Cdd:TIGR00863  78 -TSELGNRVWDVADYVKPPQGeNVFFVMTNFIVTPNQTQGRCPEHPSVPlAICWSDSDCTAGEAGTHGNGIKTGRCVPFN 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762   157 KTRKTCEVSAWCPTEEeKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNG----SCTFHKTWDPQCSIFRLG 232
Cdd:TIGR00863 157 GTVKTCEIFAWCPVEV-DTVPSPPLLKEAENFTLFIKNSIRFPKFNFSKRNILETWDAtylkTCLFDPDSDPYCPIFRLG 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84781762   233 DIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESfvPGYNFRYAKYYKENN-VEKRTLIK 311
Cdd:TIGR00863 236 DIVEEAGQDFQDLALKGGVVGITINWDCDLDKAASHCNPKYSFRRLDNKEKNVS--PGYNFRFAKYYRDNAgVETRTLLK 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 84781762   312 AFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLI 355
Cdd:TIGR00863 314 AYGIRFDILVTGKAGKFDIIPTMITIGSGLASLGVGTFLCDLIL 357
P2RX7_C pfam20478
P2X purinoreceptor 7 intracellular domain; This entry represents the intracellular domain ...
400-430 7.40e-12

P2X purinoreceptor 7 intracellular domain; This entry represents the intracellular domain found at the the C-terminus of P2X purinoreceptor 7 protein.


Pssm-ID: 466627  Cd Length: 185  Bit Score: 63.75  E-value: 7.40e-12
                          10        20        30
                  ....*....|....*....|....*....|.
gi 84781762   400 YVSFVDEPHIRMVDQQlLGKSLQVVKGQEVP 430
Cdd:pfam20478   1 YVSFVDEPHIRLVKKS-LKKSLQDVKGESVP 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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