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Conserved domains on  [gi|8392875|ref|NP_037374|]
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cilia- and flagella-associated protein 20 [Homo sapiens]

Protein Classification

CFAP20 family protein( domain architecture ID 10523413)

CFAP20 family protein is a DUF667 domain-containing protein; similar to Homo sapiens Cilia- and flagella-associated protein 20 that plays a role in axonemal structure organization and motility

Gene Ontology:  GO:0060271|GO:0018095|GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CFA20_dom pfam05018
CFA20 domain; This domain is characteriztic of cilia- and flagella-associated protein 20 ...
 1-185 4.08e-130

CFA20 domain; This domain is characteriztic of cilia- and flagella-associated protein 20 (CFA20). CFA20 is a cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. In Chlamydomonas reinhardtii, it stabilizes outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1. Other proteins contain a domain with homology to CFA20. WDR90/POC16 contains such a domain in its N terminus, followed by a large C-terminal domain with multiple WD40 repeats. This domain is also present in the N terminus of uncharacterized protein C3orf67.


:

Pssm-ID: 461521  Cd Length: 185  Bit Score: 362.68  E-value: 4.08e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392875      1 MFKNTFQSGFLSILYSIGSKPLQIWDKKVRNGHIKRITDNDIQSLVLEIEGTNVSTTYITCPADPKKTLGIKLPFLVMII 80
Cdd:pfam05018   1 MFRNTFQSGFLSIFYSIGSKPLQIWSKKVKNGHIKRVTDDDIKSNVLEIVGTNVATTYITCPADPKQSLGIKLPFLVLLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392875     81 KNLKKYFTFEVQVLDDKNVRRRFRASNYQSTTRVKPFICTMPMRLDDGWNQIQFNLLDFTRRAYGTNYIETLRVQIHANC 160
Cdd:pfam05018  81 KNLGKYFSFEIQILDDKNVRRRFRFSNFQKVTKVKPFITTMPLRLNEGWNQIQFNLADFTRRAYGTNYVETVRVQIHANC 160

                         170       180
                  ....*....|....*....|....*
gi 8392875    161 RIRRVYFSDRLYSEDELPAEFKLYL 185
Cdd:pfam05018 161 RLRRIYFSDRLYSEDELPAEFRLFL 185
 
Name Accession Description Interval E-value
CFA20_dom pfam05018
CFA20 domain; This domain is characteriztic of cilia- and flagella-associated protein 20 ...
 1-185 4.08e-130

CFA20 domain; This domain is characteriztic of cilia- and flagella-associated protein 20 (CFA20). CFA20 is a cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. In Chlamydomonas reinhardtii, it stabilizes outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1. Other proteins contain a domain with homology to CFA20. WDR90/POC16 contains such a domain in its N terminus, followed by a large C-terminal domain with multiple WD40 repeats. This domain is also present in the N terminus of uncharacterized protein C3orf67.


Pssm-ID: 461521  Cd Length: 185  Bit Score: 362.68  E-value: 4.08e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392875      1 MFKNTFQSGFLSILYSIGSKPLQIWDKKVRNGHIKRITDNDIQSLVLEIEGTNVSTTYITCPADPKKTLGIKLPFLVMII 80
Cdd:pfam05018   1 MFRNTFQSGFLSIFYSIGSKPLQIWSKKVKNGHIKRVTDDDIKSNVLEIVGTNVATTYITCPADPKQSLGIKLPFLVLLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392875     81 KNLKKYFTFEVQVLDDKNVRRRFRASNYQSTTRVKPFICTMPMRLDDGWNQIQFNLLDFTRRAYGTNYIETLRVQIHANC 160
Cdd:pfam05018  81 KNLGKYFSFEIQILDDKNVRRRFRFSNFQKVTKVKPFITTMPLRLNEGWNQIQFNLADFTRRAYGTNYVETVRVQIHANC 160

                         170       180
                  ....*....|....*....|....*
gi 8392875    161 RIRRVYFSDRLYSEDELPAEFKLYL 185
Cdd:pfam05018 161 RLRRIYFSDRLYSEDELPAEFRLFL 185
 
Name Accession Description Interval E-value
CFA20_dom pfam05018
CFA20 domain; This domain is characteriztic of cilia- and flagella-associated protein 20 ...
 1-185 4.08e-130

CFA20 domain; This domain is characteriztic of cilia- and flagella-associated protein 20 (CFA20). CFA20 is a cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. In Chlamydomonas reinhardtii, it stabilizes outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1. Other proteins contain a domain with homology to CFA20. WDR90/POC16 contains such a domain in its N terminus, followed by a large C-terminal domain with multiple WD40 repeats. This domain is also present in the N terminus of uncharacterized protein C3orf67.


Pssm-ID: 461521  Cd Length: 185  Bit Score: 362.68  E-value: 4.08e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392875      1 MFKNTFQSGFLSILYSIGSKPLQIWDKKVRNGHIKRITDNDIQSLVLEIEGTNVSTTYITCPADPKKTLGIKLPFLVMII 80
Cdd:pfam05018   1 MFRNTFQSGFLSIFYSIGSKPLQIWSKKVKNGHIKRVTDDDIKSNVLEIVGTNVATTYITCPADPKQSLGIKLPFLVLLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392875     81 KNLKKYFTFEVQVLDDKNVRRRFRASNYQSTTRVKPFICTMPMRLDDGWNQIQFNLLDFTRRAYGTNYIETLRVQIHANC 160
Cdd:pfam05018  81 KNLGKYFSFEIQILDDKNVRRRFRFSNFQKVTKVKPFITTMPLRLNEGWNQIQFNLADFTRRAYGTNYVETVRVQIHANC 160

                         170       180
                  ....*....|....*....|....*
gi 8392875    161 RIRRVYFSDRLYSEDELPAEFKLYL 185
Cdd:pfam05018 161 RLRRIYFSDRLYSEDELPAEFRLFL 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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