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Conserved domains on  [gi|837909242|ref|WP_047894914|]
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F0F1 ATP synthase subunit A [Caballeronia mineralivorans]

Protein Classification

FoF1 ATP synthase subunit a; ATP synthase F0 subunit 6( domain architecture ID 10014231)

FoF1 ATP synthase subunit a is part of the membrane proton channel (Fo complex) of the F-type ATPase that produces ATP from ADP in the presence of a proton gradient across the membrane; it plays a direct role in the translocation of protons across the membrane; ATP synthase F0 subunit 6 is part of the mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V), which produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13421 PRK13421
F0F1 ATP synthase subunit A; Provisional
 1-219 8.60e-134

F0F1 ATP synthase subunit A; Provisional


:

Pssm-ID: 237383  Cd Length: 223  Bit Score: 375.19  E-value: 8.60e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   1 MIASPLATATLFHIGPIGVSAPVVATWAIMALLAGGSAWTTRRLSLTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRAL 80
Cdd:PRK13421   1 MTASPLSTVPLFSLGPVPISAPVVVTWAIMAVLAAGSALATRRLSLAPGRLQSVLELVVTTIDAQIRDTMQTDPAPYRAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  81 VGTLFLFILVSNWSSLLPGVEPPTAHVETDAALALIVFCATIFYGIRTRGLGRYLATFAEPTWIMIPLNVVEQITRTFSL 160
Cdd:PRK13421  81 IGTLFLFVLVANWSSLVPGVEPPTAHLETDAALALIVFLATIYYGVRARGVRGYLATFAEPTWVMIPLNLVEQLTRTFSL 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 837909242 161 VVRLFGNVMSGVFVVGIVLSLAGLLVPIPLMALDLLTGAVQAYIFTVLAMVFIGAALAE 219
Cdd:PRK13421 161 IVRLFGNVMSGVFVIGIVLSLAGLLVPIPLMALDLLTGAVQAYIFAVLAMVFIGAAVSD 219
 
Name Accession Description Interval E-value
PRK13421 PRK13421
F0F1 ATP synthase subunit A; Provisional
 1-219 8.60e-134

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237383  Cd Length: 223  Bit Score: 375.19  E-value: 8.60e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   1 MIASPLATATLFHIGPIGVSAPVVATWAIMALLAGGSAWTTRRLSLTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRAL 80
Cdd:PRK13421   1 MTASPLSTVPLFSLGPVPISAPVVVTWAIMAVLAAGSALATRRLSLAPGRLQSVLELVVTTIDAQIRDTMQTDPAPYRAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  81 VGTLFLFILVSNWSSLLPGVEPPTAHVETDAALALIVFCATIFYGIRTRGLGRYLATFAEPTWIMIPLNVVEQITRTFSL 160
Cdd:PRK13421  81 IGTLFLFVLVANWSSLVPGVEPPTAHLETDAALALIVFLATIYYGVRARGVRGYLATFAEPTWVMIPLNLVEQLTRTFSL 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 837909242 161 VVRLFGNVMSGVFVVGIVLSLAGLLVPIPLMALDLLTGAVQAYIFTVLAMVFIGAALAE 219
Cdd:PRK13421 161 IVRLFGNVMSGVFVIGIVLSLAGLLVPIPLMALDLLTGAVQAYIFAVLAMVFIGAAVSD 219
AtpB COG0356
FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP ...
 22-219 2.11e-68

FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit a is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440125 [Multi-domain]  Cd Length: 212  Bit Score: 209.16  E-value: 2.11e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  22 PVVATWAIMALLAGGSAWTTRRLSLTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFLFILVSNWSSLLPGVE 101
Cdd:COG0356    2 TVLMSWLAMLLLLLLFLLATRKLKLVPGGLQNFVEMLVEFVRNQVKDTIGKKGRKFAPLLLTLFLFILVSNLLGLIPGLF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242 102 PPTAHVETDAALALIVFCATIFYGIRTRGLGRYLAT-FAEPTW----IMIPLNVVEQITRTFSLVVRLFGNVMSGVFVVG 176
Cdd:COG0356   82 PPTADINVTLALALIVFVLVHYYGIKKKGLGGYLKHlFFPPFPwlapLMLPIEIISELARPLSLSLRLFGNMFAGHIILL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 837909242 177 IVLSLAG--------LLVPIPLMALDLLTGAVQAYIFTVLAMVFIGAALAE 219
Cdd:COG0356  162 LLAGLAPflllgvlsLLLPVAWTAFELLVGFLQAYIFTMLTAVYISLAVEE 212
altF1_A TIGR03306
alternate F1F0 ATPase, F0 subunit A; A small number of taxonomically diverse prokaryotic ...
 15-216 2.63e-64

alternate F1F0 ATPase, F0 subunit A; A small number of taxonomically diverse prokaryotic species have what appears to be a second ATP synthase, in addition to the normal F1F0 ATPase in bacteria and A1A0 ATPase in archaea. These enzymes use ion gradients to synthesize ATP, and in principle may run in either direction. This model represents the F0 subunit A of this apparent second ATP synthase.


Pssm-ID: 132349  Cd Length: 217  Bit Score: 198.81  E-value: 2.63e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   15 GPIGVSAPVVATWAIMALLAGGSAWTTRRLS--LTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFLFILVSN 92
Cdd:TIGR03306  12 GFVKINATIAFTWLLMLLLVIGSWLITRRLStgLERSRWQNLLEVLVTGIQEQISDVGLAKPRKYLPFLGTLFLFIAVAN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   93 WSSLLPGVEPPTAHVETDAALALIVFCATIFYGIRTRGLGRYLATFAEPTWIMIPLNVVEQITRTFSLVVRLFGNVMSGV 172
Cdd:TIGR03306  92 LLSVIPGYEPPTGSLSTTAALALCVFVAVPLFGIAERGLSGYLKSYLKPTPFMLPFNIIGELSRTLALAVRLFGNMMSGS 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 837909242  173 FVVGIVLSLAGLLVPIPLMALDLLTGAVQAYIFTVLAMVFIGAA 216
Cdd:TIGR03306 172 MILAILLSISPLIFPVLMQVLGLLTGMVQAYIFSVLATVYIAAA 215
ATP-synt_A pfam00119
ATP synthase A chain;
23-214 7.59e-45

ATP synthase A chain;


Pssm-ID: 459679 [Multi-domain]  Cd Length: 216  Bit Score: 149.18  E-value: 7.59e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   23 VVATWAIMALLAGGSAWTTRRLS-LTPSRMQTVLELVVSTIDDQIRDTM-QAEPERYRALVGTLFLFILVSNWSSLL--- 97
Cdd:pfam00119   1 LLMSLIVALILLLFLLLATRKTKkLVPGRLQNFVEMLVEFVDNIVKDNIgKKKGRKFFPLLLTLFFFILVSNLLGLIpks 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   98 PGVEPPTAHVETDAALALIVFCATIFYGIRTRGLGRYLATFAEP------TWIMIPLNVVEQITRTFSLVVRLFGNVMSG 171
Cdd:pfam00119  81 PGGFTVTADINVTLALALIVFLLVHYYGIKKHGLGGYFKKLFVPpvplplVPLLLPIEIISEFARPVSLSLRLFGNMLAG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 837909242  172 VFVVGIVLSLAG-------------LLVPIPLMALDLLTGAVQAYIFTVLAMVFIG 214
Cdd:pfam00119 161 HLLLLLLAGLIFallsagfllgvipPLLGVAWTLFELLVAFIQAYVFTMLTAVYIS 216
ATP-synt_Fo_a_6 cd00310
ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms ...
 75-214 1.78e-40

ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms are designated as ATP synthase, Fo complex, subunit a; eukaryotic (chloroplast and mitochondrial) forms are designated as ATP synthase, Fo complex, subunit 6. The F-ATP synthases (also called FoF1-ATPases) consist of two structural domains: F1 (factor one) complex containing the soluble catalytic core, and Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. F-ATP synthase has also been found in the archaea Methanosarcina acetivorans. F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis.


Pssm-ID: 349411 [Multi-domain]  Cd Length: 156  Bit Score: 135.99  E-value: 1.78e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  75 ERYRALVGTLFLFILVSNWSSLLPGVEPPTAHVETDAALALIVFCATIFYGIRTRGLGRYLA-----TFAEPTWIMIPLN 149
Cdd:cd00310    2 KKYLPLLGTLFLFILFSNLLGLIPYSFTPTSHLNVTLALALIVFLGVHILGIKKHGLGFFLHflppgTPLPLAPLMVPIE 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 837909242 150 VVEQITRTFSLVVRLFGNVMSGVFVVGIVLSLA----------GLLVPIPLMALDLLTGAVQAYIFTVLAMVFIG 214
Cdd:cd00310   82 LISELIRPLSLSVRLFANMFAGHLLLALLSGLVpsllssvgllPLLLPVALTLLELFVAFIQAYVFTLLTAVYIS 156
 
Name Accession Description Interval E-value
PRK13421 PRK13421
F0F1 ATP synthase subunit A; Provisional
 1-219 8.60e-134

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237383  Cd Length: 223  Bit Score: 375.19  E-value: 8.60e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   1 MIASPLATATLFHIGPIGVSAPVVATWAIMALLAGGSAWTTRRLSLTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRAL 80
Cdd:PRK13421   1 MTASPLSTVPLFSLGPVPISAPVVVTWAIMAVLAAGSALATRRLSLAPGRLQSVLELVVTTIDAQIRDTMQTDPAPYRAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  81 VGTLFLFILVSNWSSLLPGVEPPTAHVETDAALALIVFCATIFYGIRTRGLGRYLATFAEPTWIMIPLNVVEQITRTFSL 160
Cdd:PRK13421  81 IGTLFLFVLVANWSSLVPGVEPPTAHLETDAALALIVFLATIYYGVRARGVRGYLATFAEPTWVMIPLNLVEQLTRTFSL 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 837909242 161 VVRLFGNVMSGVFVVGIVLSLAGLLVPIPLMALDLLTGAVQAYIFTVLAMVFIGAALAE 219
Cdd:PRK13421 161 IVRLFGNVMSGVFVIGIVLSLAGLLVPIPLMALDLLTGAVQAYIFAVLAMVFIGAAVSD 219
AtpB COG0356
FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP ...
 22-219 2.11e-68

FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit a is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440125 [Multi-domain]  Cd Length: 212  Bit Score: 209.16  E-value: 2.11e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  22 PVVATWAIMALLAGGSAWTTRRLSLTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFLFILVSNWSSLLPGVE 101
Cdd:COG0356    2 TVLMSWLAMLLLLLLFLLATRKLKLVPGGLQNFVEMLVEFVRNQVKDTIGKKGRKFAPLLLTLFLFILVSNLLGLIPGLF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242 102 PPTAHVETDAALALIVFCATIFYGIRTRGLGRYLAT-FAEPTW----IMIPLNVVEQITRTFSLVVRLFGNVMSGVFVVG 176
Cdd:COG0356   82 PPTADINVTLALALIVFVLVHYYGIKKKGLGGYLKHlFFPPFPwlapLMLPIEIISELARPLSLSLRLFGNMFAGHIILL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 837909242 177 IVLSLAG--------LLVPIPLMALDLLTGAVQAYIFTVLAMVFIGAALAE 219
Cdd:COG0356  162 LLAGLAPflllgvlsLLLPVAWTAFELLVGFLQAYIFTMLTAVYISLAVEE 212
altF1_A TIGR03306
alternate F1F0 ATPase, F0 subunit A; A small number of taxonomically diverse prokaryotic ...
 15-216 2.63e-64

alternate F1F0 ATPase, F0 subunit A; A small number of taxonomically diverse prokaryotic species have what appears to be a second ATP synthase, in addition to the normal F1F0 ATPase in bacteria and A1A0 ATPase in archaea. These enzymes use ion gradients to synthesize ATP, and in principle may run in either direction. This model represents the F0 subunit A of this apparent second ATP synthase.


Pssm-ID: 132349  Cd Length: 217  Bit Score: 198.81  E-value: 2.63e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   15 GPIGVSAPVVATWAIMALLAGGSAWTTRRLS--LTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFLFILVSN 92
Cdd:TIGR03306  12 GFVKINATIAFTWLLMLLLVIGSWLITRRLStgLERSRWQNLLEVLVTGIQEQISDVGLAKPRKYLPFLGTLFLFIAVAN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   93 WSSLLPGVEPPTAHVETDAALALIVFCATIFYGIRTRGLGRYLATFAEPTWIMIPLNVVEQITRTFSLVVRLFGNVMSGV 172
Cdd:TIGR03306  92 LLSVIPGYEPPTGSLSTTAALALCVFVAVPLFGIAERGLSGYLKSYLKPTPFMLPFNIIGELSRTLALAVRLFGNMMSGS 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 837909242  173 FVVGIVLSLAGLLVPIPLMALDLLTGAVQAYIFTVLAMVFIGAA 216
Cdd:TIGR03306 172 MILAILLSISPLIFPVLMQVLGLLTGMVQAYIFSVLATVYIAAA 215
PRK05815 PRK05815
F0F1 ATP synthase subunit A; Validated
 12-219 1.93e-62

F0F1 ATP synthase subunit A; Validated


Pssm-ID: 235617  Cd Length: 227  Bit Score: 194.63  E-value: 1.93e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  12 FHIGPIGVSAPVVATWAIMALLAGGSAWTTRRLSLTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFLFILVS 91
Cdd:PRK05815   7 IGFGGFNFDSLLLSVLLGVLILLLFALVATRKLSGVPGGLQNFVEMIVEFVRGQVKDNIGGKGKKFAPLAFTLFLFILLM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  92 NWSSLLP-GVEPPTAHVETDAALALIVFCATIFYGIRTRGLGRYLA-TFAEPTWIMIPLNVVEQITRTFSLVVRLFGNVM 169
Cdd:PRK05815  87 NLLGLIPyLLFPPTADINVTLALALIVFVLVIYYGIKKKGLGGYLKeFYLQPHPLLLPIEIISEFSRPISLSLRLFGNML 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 837909242 170 SG---------VFVVGIVLSLAGLLVPIPLMALDLLTGAVQAYIFTVLAMVFIGAALAE 219
Cdd:PRK05815 167 AGelilalialLGGAGLLLALAPLILPVAWTIFEIFVGTLQAYIFMMLTIVYISMAVEE 225
PRK13420 PRK13420
F0F1 ATP synthase subunit A; Provisional
 7-227 1.24e-56

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237382 [Multi-domain]  Cd Length: 226  Bit Score: 179.55  E-value: 1.24e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   7 ATATLFHIGPIGVSAPVVATWAIMALLAGGSAWTTRRLSLTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFL 86
Cdd:PRK13420   4 LAHVLFHIGPLPITESVLTTWGIMIVLVLASWLTTRRLSLDPGRFQVALEGVVSTIEDAIKEVLPRHARLVLPFVGTLWI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  87 FILVSNWSSLLPGVEPPTAHVETDAALALIVFCATIFYGIRTRGLGRYLATFAEPTWIMIPLNVVEQITRTFSLVVRLFG 166
Cdd:PRK13420  84 FILVANLIGLIPGFHSPTADLSVTAALALLVFFSVHWFGIRAEGLREYLKHYLSPSPFLLPFHLISEITRTLALAVRLFG 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 837909242 167 NVMSGVFVVGIVLSLAGLLVPIPLMALDLLTGAVQAYIFTVLAMVFIGAALAENSANTSSK 227
Cdd:PRK13420 164 NIMSLELAALLVLLVAGFLVPVPILMLHIIEALVQAYIFGMLALIYIAGGIQAHELKSQGE 224
ATP-synt_A pfam00119
ATP synthase A chain;
23-214 7.59e-45

ATP synthase A chain;


Pssm-ID: 459679 [Multi-domain]  Cd Length: 216  Bit Score: 149.18  E-value: 7.59e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   23 VVATWAIMALLAGGSAWTTRRLS-LTPSRMQTVLELVVSTIDDQIRDTM-QAEPERYRALVGTLFLFILVSNWSSLL--- 97
Cdd:pfam00119   1 LLMSLIVALILLLFLLLATRKTKkLVPGRLQNFVEMLVEFVDNIVKDNIgKKKGRKFFPLLLTLFFFILVSNLLGLIpks 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   98 PGVEPPTAHVETDAALALIVFCATIFYGIRTRGLGRYLATFAEP------TWIMIPLNVVEQITRTFSLVVRLFGNVMSG 171
Cdd:pfam00119  81 PGGFTVTADINVTLALALIVFLLVHYYGIKKHGLGGYFKKLFVPpvplplVPLLLPIEIISEFARPVSLSLRLFGNMLAG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 837909242  172 VFVVGIVLSLAG-------------LLVPIPLMALDLLTGAVQAYIFTVLAMVFIG 214
Cdd:pfam00119 161 HLLLLLLAGLIFallsagfllgvipPLLGVAWTLFELLVAFIQAYVFTMLTAVYIS 216
atpI CHL00046
ATP synthase CF0 A subunit
 14-214 1.30e-40

ATP synthase CF0 A subunit


Pssm-ID: 176987  Cd Length: 228  Bit Score: 138.53  E-value: 1.30e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  14 IGPIGVSAPVVAT-WAIMALLAGGSAWTTRRLSLTPSRMQTVLELVVSTIDDQIRDTM-QAEPERYRALVGTLFLFILVS 91
Cdd:CHL00046  16 IGGFQVHGQVLITsWVVIAILLGSALLATRNLQTIPTGGQNFFEYVLEFIRDLAKTQIgEEEYRPWVPFIGTMFLFIFVS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  92 NWS--------SLLPGVE--PPTAHVETDAALALIVFCATIFYGIRTRGLGrYLATFAEPTWIMIPLNVVEQITRTFSLV 161
Cdd:CHL00046  96 NWSgallpwklIELPHGElaAPTNDINTTVALALLTSVAYFYAGLSKKGLG-YFGKYIQPTPILLPINILEDFTKPLSLS 174

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 837909242 162 VRLFGNVMSGVFVVGIVLSLAGLLVPIPLMALDLLTGAVQAYIFTVLAMVFIG 214
Cdd:CHL00046 175 FRLFGNILADELVVAVLVSLVPLVVPIPVMFLGLFTSGIQALIFATLAAAYIG 227
ATP-synt_Fo_a_6 cd00310
ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms ...
 75-214 1.78e-40

ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms are designated as ATP synthase, Fo complex, subunit a; eukaryotic (chloroplast and mitochondrial) forms are designated as ATP synthase, Fo complex, subunit 6. The F-ATP synthases (also called FoF1-ATPases) consist of two structural domains: F1 (factor one) complex containing the soluble catalytic core, and Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. F-ATP synthase has also been found in the archaea Methanosarcina acetivorans. F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis.


Pssm-ID: 349411 [Multi-domain]  Cd Length: 156  Bit Score: 135.99  E-value: 1.78e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  75 ERYRALVGTLFLFILVSNWSSLLPGVEPPTAHVETDAALALIVFCATIFYGIRTRGLGRYLA-----TFAEPTWIMIPLN 149
Cdd:cd00310    2 KKYLPLLGTLFLFILFSNLLGLIPYSFTPTSHLNVTLALALIVFLGVHILGIKKHGLGFFLHflppgTPLPLAPLMVPIE 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 837909242 150 VVEQITRTFSLVVRLFGNVMSGVFVVGIVLSLA----------GLLVPIPLMALDLLTGAVQAYIFTVLAMVFIG 214
Cdd:cd00310   82 LISELIRPLSLSVRLFANMFAGHLLLALLSGLVpsllssvgllPLLLPVALTLLELFVAFIQAYVFTLLTAVYIS 156
ATP_synt_6_or_A TIGR01131
ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be ...
 12-217 2.53e-28

ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be designated ATP synthase, F0 subunit A; eukaryotic (chloroplast and mitochondrial) forms should be designated ATP synthase, F0 subunit 6. The F1/F0 ATP synthase is a multisubunit, membrane associated enzyme found in bacteria and mitochondria and chloroplast. This enzyme is principally involved in the synthesis of ATP from ADP and inorganic phosphate by coupling the energy derived from the proton electrochemical gradient across the biological membrane. A brief description of this multisubunit enzyme complex: F1 and F0 represent two major clusters of subunits. Individual subunits in each of these clusters are named differently in prokaryotes and in organelles e.g., mitochondria and chloroplast. The bacterial equivalent of subunit 6 is named subunit 'A'. It has been shown that proton is conducted though this subunit. Typically, deprotonation and reprotonation of the acidic amino acid side-chains are implicated in the process. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273458  Cd Length: 226  Bit Score: 106.91  E-value: 2.53e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   12 FHIGPIGVSAPVVATWAIMALLAGGSAWTTRRLSLTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFLFILVS 91
Cdd:TIGR01131   5 FDISPITLFSLTLLSLILLLSLLIFLISSSLSRWLIPSRWQNLMESIYEFVLSIVKSQIGGKKGKFFPLIFTLFLFILIS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242   92 NWSSLLPGVEPPTAHVETDAALALIVFCATIFYGIRTRGLGR--YLATFAEPTWI---MIPLNVVEQITRTFSLVVRLFG 166
Cdd:TIGR01131  85 NLLGLIPYSFTPTSHLSFTLGLALPLWLGLTISGFRKHPKGFlaHLVPSGTPLPLipfLVIIETISYLARPISLSVRLFA 164

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 837909242  167 NVMSGVFVVGIVLSLA-----------GLLVPIPLMALDLLTGAVQAYIFTVLAMVFIGAAL 217
Cdd:TIGR01131 165 NISAGHLLLTLLSGLLfslmssaifalLLLILVALIILEIFVAFIQAYVFTLLTCLYLNDAL 226
PRK13419 PRK13419
F0F1 ATP synthase subunit A; Provisional
 23-218 9.97e-21

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237381  Cd Length: 342  Bit Score: 88.65  E-value: 9.97e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  23 VVATWAIMALL-----AGGSAWTTRRLSLTPSRMQTVLELVVSTIDDQI-RDTMQAEPERYRALVGTLFLFILVSNWSSL 96
Cdd:PRK13419 110 VVMMWIASAILlvvflAAGRKYKKMTKSQAPKGLANAMEALVEFIRLDVaKSNIGHGYEKFLPYLLTVFFFILVCNLLGL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  97 LPGVEPPTAHVETDAALALIVFCATIFYGIRTRGLGRYLATFAEPT----W-IMIPLNVVEQITRTFSLVVRLFGNVMSG 171
Cdd:PRK13419 190 VPYGATATGNINVTLTLAVFTFFITQYAAIKAHGIKGYLAHLTGGThwslWiIMIPIEFIGLFTKPFALTVRLFANMTAG 269

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 837909242 172 VFVvgiVLSLAGLL-------------VP--IPLMALDLLTGAVQAYIFTVLAMVFIGAALA 218
Cdd:PRK13419 270 HIV---ILSLIFISfilksyivavavsVPfaIFIYLLELFVAFLQAYIFTMLSALFIGLATA 328
ATP6 MTH00175
ATP synthase F0 subunit 6; Provisional
 46-218 3.10e-10

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177228  Cd Length: 244  Bit Score: 58.48  E-value: 3.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  46 LTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFLFILVSNWSSLLPGVEPPTAHVETDAALALIVFCATIFYG 125
Cdd:MTH00175  51 LIPNRWQSIMELIYLNIRSVVHDNLGKSGQKYFPFILSLFLFIAILNILGLFPYVFTPTAHIIITFGLSLSIIIAVTLLG 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242 126 IRTRGLG--RYLATFAEPTWIMIPLNVVEQI---TRTFSLVVRLFGNVMSGVFVVGI--------------VLSLAGLLV 186
Cdd:MTH00175 131 FLTFKWNflSILMPGGAPLVLAPFLVLIETLsylIRAISLGVRLAANISAGHLLFAIlsgfafnmlsngliILSLFPMLI 210

                        170       180       190
                 ....*....|....*....|....*....|..
gi 837909242 187 PIPLMALDLLTGAVQAYIFTVLAMVFIGAALA 218
Cdd:MTH00175 211 MIFITLLEMAVAVIQAYVFCLLTTIYLGDTIA 242
ATP6 MTH00176
ATP synthase F0 subunit 6; Provisional
 39-209 1.36e-08

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214449  Cd Length: 229  Bit Score: 53.50  E-value: 1.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  39 WTTRRLSLTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFLFILVSNWSSLLPGVEPPTAHVETDAALALIVF 118
Cdd:MTH00176  33 LMPSSVWFCPSKLQVFMLMFSTFLPEMILRSNGSYILGSASIIISLFILVMSLNLSGLIPYVFTSTSHLVITLSLALPLW 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242 119 CATIFYGIRtRGLGRYLATF---AEPTWIMIPLNVVEQIT---RTFSLVVR-------------LFGNVMSGVFVVGIVL 179
Cdd:MTH00176 113 LGVILSGFI-NNFYSRLSHLvpqGTPPLLNPFLVLIELVSlliRPLTLAVRlaanlsaghlllgLLGAAMWGLLPVSPLI 191

                        170       180       190
                 ....*....|....*....|....*....|
gi 837909242 180 SLAGLLVPIPLMALDLLTGAVQAYIFTVLA 209
Cdd:MTH00176 192 GFLLLIVQILYFMFEIAVCMIQAYVFTLLL 221
ATP6 MTH00174
ATP synthase F0 subunit 6; Provisional
 45-213 1.87e-08

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 133799  Cd Length: 252  Bit Score: 53.40  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  45 SLTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFLFILVSNWSSLLPGVEPPTAHVETDAALALIVFCATIFY 124
Cdd:MTH00174  58 TLVPNRILVGLELIYSHFYTVLKDNLGNKGGNYLAFVLSLFILILFGNGLGLFPYVFTPTVHMVITLGLSFAIIVGTTLA 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242 125 GIRTRGLGRY--LATFAEPTWIMIPLNVVEQ---ITRTFSLVVRLFGNVMSGVFVVGIVLSLA----------GLLVPIP 189
Cdd:MTH00174 138 GLITFRFNFFsiLMPQGAPLALAPLLTIIETlsyISRAISLGVRLAANISSGHLLFSIIASFAwkmintgiliGSFVPFA 217

                        170       180
                 ....*....|....*....|....*...
gi 837909242 190 LMA----LDLLTGAVQAYIFTVLAMVFI 213
Cdd:MTH00174 218 ILIfvtiLEMAVAIIQAYVFTLLTIVYL 245
ATP6 MTH00172
ATP synthase F0 subunit 6; Provisional
 46-218 3.56e-08

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214447  Cd Length: 232  Bit Score: 52.35  E-value: 3.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  46 LTPSRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFLFILVSNWSSLLPGVEPPTAHVETDAALALIVFCATIFYG 125
Cdd:MTH00172  40 LIPKRWQSIIEIIYNHFHGVVKDNLGNEGLKYFPFIISLFFFIVFLNLLGLFPYVFTPTTHIVVTLGLSFSIIIGVTLAG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242 126 IrTRGLGRYLATF--AEPTWIMIPLNV----VEQITRTFSLVVRLFGNVMSG-------------VFVVGIVLSLAGLLV 186
Cdd:MTH00172 120 F-WRFKWDFFSILmpSGAPLGLAPLLVlietVSYISRAISLGVRLAANLSAGhllfailagfgfnMLCASGFLSLFPLLI 198

                        170       180       190
                 ....*....|....*....|....*....|..
gi 837909242 187 PIPLMALDLLTGAVQAYIFTVLAMVFIGAALA 218
Cdd:MTH00172 199 MVFITLLEIAVAVIQAYVFCLLTTIYLADTIV 230
ATP6 MTH00179
ATP synthase F0 subunit 6; Provisional
 49-208 2.15e-05

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177230  Cd Length: 227  Bit Score: 44.17  E-value: 2.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  49 SRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFLFILVSNWSSLLPGVEPPTAHVETDAALALIVFCATIFYGIR- 127
Cdd:MTH00179  41 NRLSTLQSWFFGSFTFQLMQPINKKGHKWAVLFLSLMLFLLTLNLLGLLPYTFTPTTQLSLNLGLALPLWLGTVLYGLFn 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242 128 --TRGLGRYLATFAePTWIMIPLNVVEQIT---RTFSLVVRLFGNVM----------SGVFVVGIVLSLAGLLVPIPLMA 192
Cdd:MTH00179 121 qpTIALAHLLPEGT-PTPLIPMLVWIETISlliRPLALGVRLTANITaghllmhlisSAVFVLMNFMGMVALLTLLVLFL 199

                        170
                 ....*....|....*....
gi 837909242 193 LDLLTGAV---QAYIFTVL 208
Cdd:MTH00179 200 LTLLEVAVamiQAYVFVLL 218
ATP6 MTH00173
ATP synthase F0 subunit 6; Provisional
 80-208 1.30e-04

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214448  Cd Length: 231  Bit Score: 41.77  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  80 LVGTLFLFILVSNWSSLLPGVEPPTAHVETDAALALIVFCATIFYGIrTRGLGRYLAtFAEPT---WIMIP-LNVVEQIT 155
Cdd:MTH00173  74 LLSSLFLFLISLNLSGLLPFVFSVTSHLAFTFSLALPLWLSLILSGL-FYNPSKSLA-GLVPAgapAGLNPfLVLIETVS 151

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242 156 ---RTFSLVVRLFGNV--------------MSGVFVVGIVLSLAGLLVPIPLMALDLLTGAVQAYIFTVL 208
Cdd:MTH00173 152 iliRPLTLTVRLLANIsaghivltlignylSSSLFSSSVVSLLLVLLIQVGYFIFEVAVMLIQAYIFTLL 221
ATP6 MTH00005
ATP synthase F0 subunit 6; Provisional
 29-208 1.42e-04

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 164583  Cd Length: 231  Bit Score: 41.64  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  29 IMALLAGGSAWTTrrlsltPSRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFLFILVSNWSSLLPGVEPPTAHVE 108
Cdd:MTH00005  31 SIILLLSSSFWIT------PNRLSSIMSPPKSTMHTQLSRTFGKHLKGFSSLISALFTMIILMNLSGLLPYVFSTSSHLI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242 109 TDAALALIVFCATIFYGIrTRGLGRYLATF---AEPTWIMIPLNVVEQIT---RTFSLVVRLFGNVMSGvfvvGIVLSLA 182
Cdd:MTH00005 105 FTLTLGLPLWLSLIMSSV-TFSPKKFAAHLlpgGAPDWLNPFLVLIETISilvRPITLSFRLAANMSAG----HIVLSLI 179

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 837909242 183 G------LLVPIPLMALDLLTGA-----------VQAYIFTVL 208
Cdd:MTH00005 180 GiyaasaLFSSISSTILLILTQMgyilfevgiclIQAYIFCLL 222
PRK13417 PRK13417
F0F1 ATP synthase subunit A; Provisional
 49-217 3.80e-04

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237380  Cd Length: 352  Bit Score: 41.03  E-value: 3.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  49 SRMQTVLELVVSTIDDQIRD-TMQAEPERYRALVGTLFLFILVSNWSSLLPGV-EPPTAHVETDAALALIV--------- 117
Cdd:PRK13417 128 SRFANTVEVFVNFLRKDIVDeSMHGHGHSYYHYIFTLFFFILFCNLMGLVPSVgELTVVASDYGGLVALGVmdhtphalp 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242 118 FCATIFYGIRTRG-------------LGRYLATFAE----------------PTW-IMIPLN-VVEQITRTFSLVVRLFG 166
Cdd:PRK13417 208 TFAKVWSGITVTGdisvtmtlalltmFLIYGAGFSYqgpkfiwhsvpngvplLLYpIMWPLEfIVSPMAKTFALTVRLLA 287

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 837909242 167 NVMSGVFVV-----GIVLSLAGLLVPIPLMA------LDLLTGAVQAYIFTVLAMVFIGAAL 217
Cdd:PRK13417 288 NMTAGHVIIlalmgFIFQFQSWGIVPVSVIGsgliyvLEIFVAFLQAYIFVLLTSLFVGLSM 349
ATP6 MTH00157
ATP synthase F0 subunit 6; Provisional
 83-208 1.92e-03

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214441  Cd Length: 223  Bit Score: 38.23  E-value: 1.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  83 TLFLFILVSNWSSLLPGVEPPTAHVETDAALALIVFCATIFYGIrtrgLGRYLATFAEptwiMIPLN----------VVE 152
Cdd:MTH00157  74 SLFSFILFNNFLGLFPYIFTSTSHLSLTLSLALPLWLSFMLFGW----INNTNHMFAH----LVPQGtppilmpfmvLIE 145

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 837909242 153 QIT---RTFSLVVRLFGNVMSGVFVVG----IVLSLAGLLVPI---PLMALDLLTGAV---QAYIFTVL 208
Cdd:MTH00157 146 TISnliRPGTLAVRLAANMIAGHLLLTllgnTGPSLSSMILSIlilIQILLLILESAVaiiQSYVFSVL 214
ATP6 MTH00073
ATP synthase F0 subunit 6; Provisional
 47-208 2.49e-03

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177144  Cd Length: 227  Bit Score: 38.02  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242  47 TPSRMQTVLELVVSTIDDQIRDTMQAEPERYRALVGTLFLFILVSNWSSLLPGVEPPTAHVETDAALALIVFCATIFYGI 126
Cdd:MTH00073  39 LNNRLSTLQIWFLQNFTKQLMLPLNTPGHKWALILTSLMVFLITMNLLGLLPYTFTPTTQLSLNLGLAVPLWLATVLIGL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 837909242 127 R---TRGLGRYLATfAEPTWIMIPLNVVEQIT---RTFSLVVRLFGNVMSG----------VFVVGIVLSLAGLLVPIPL 190
Cdd:MTH00073 119 RnqpTASLGHLLPE-GTPTLLIPILIIIETISlfiRPLALGVRLTANLTAGhlliqlistaTLVLLPLMPTVSILTMIVL 197

                        170       180
                 ....*....|....*....|.
gi 837909242 191 MALDLLTGAV---QAYIFTVL 208
Cdd:MTH00073 198 FLLTLLEIAVamiQAYVFVLL 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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