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Conserved domains on  [gi|835226354|ref|WP_047405272|]
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MULTISPECIES: ANTAR domain-containing response regulator [unclassified Caulobacter]

Protein Classification

ANTAR domain-containing response regulator( domain architecture ID 11467116)

response regulator with a signal receiver (REC) domain and RNA binding antiterminator (ANTAR) domain involved in transcriptional antitermination, similar to Mycobacterium tuberculosis transcriptional regulatory protein pdtaR that is a member of the two-component regulatory system pdtaR/pdtaS

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-187 1.77e-52

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 166.29  E-value: 1.77e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835226354   1 MRVLVIDPDTARAALVAQGLE--GVQPLEVRRSAVYDEAEVMAFAPDVVVIAAESPDRDTLDSLQESSQGH--PVVMFVD 76
Cdd:COG3707    4 LRVLVVDDEPLRRADLREGLReaGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERpaPVILLTA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835226354  77 RSEPGLAEQAVRAGVAAYVVDGLAPNRVRSILDVAMSRFALTQQLRGDLAKAKADLESRKTVERAKGLLMKERGLDEDGA 156
Cdd:COG3707   84 YSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSEDEA 163

                        170       180       190
                 ....*....|....*....|....*....|.
gi 835226354 157 YRLLRKLAMDRGKPIGAVAADLLAFAGVLKG 187
Cdd:COG3707  164 YRLLRKQAMDRRVKLAEVAEAILAAAELLKG 194
 
Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-187 1.77e-52

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 166.29  E-value: 1.77e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835226354   1 MRVLVIDPDTARAALVAQGLE--GVQPLEVRRSAVYDEAEVMAFAPDVVVIAAESPDRDTLDSLQESSQGH--PVVMFVD 76
Cdd:COG3707    4 LRVLVVDDEPLRRADLREGLReaGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERpaPVILLTA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835226354  77 RSEPGLAEQAVRAGVAAYVVDGLAPNRVRSILDVAMSRFALTQQLRGDLAKAKADLESRKTVERAKGLLMKERGLDEDGA 156
Cdd:COG3707   84 YSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSEDEA 163

                        170       180       190
                 ....*....|....*....|....*....|.
gi 835226354 157 YRLLRKLAMDRGKPIGAVAADLLAFAGVLKG 187
Cdd:COG3707  164 YRLLRKQAMDRRVKLAEVAEAILAAAELLKG 194
ANTAR smart01012
ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found ...
 125-179 4.53e-15

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; The majority of the domain consists of a coiled-coil.


Pssm-ID: 198080 [Multi-domain]  Cd Length: 55  Bit Score: 65.96  E-value: 4.53e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 835226354   125 LAKAKADLESRKTVERAKGLLMKERGLDEDGAYRLLRKLAMDRGKPIGAVAADLL 179
Cdd:smart01012   1 LEQLREALESRKVIEQAKGILMERRGLSEEEAFELLRKLAMDRNVKLRDVAEAIV 55
ANTAR pfam03861
ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding ...
 132-176 4.95e-15

ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.


Pssm-ID: 427550 [Multi-domain]  Cd Length: 46  Bit Score: 65.82  E-value: 4.95e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 835226354  132 LESRKTVERAKGLLMKERGLDEDGAYRLLRKLAMDRGKPIGAVAA 176
Cdd:pfam03861   2 LESRKVIEQAKGILMERLGLSEDEAFRLLRKLSMDRNVKLREVAE 46
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 4-96 9.80e-04

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 37.21  E-value: 9.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835226354   4 LVIDPDTARAALVAQGLEGvQPLEVRRSAVYDEAEVMA--FAPDVVVIAAESPDRD---TLDSLQESSQGHPVVMFVDRS 78
Cdd:cd00156    1 LIVDDDPAIRELLKSLLER-EGYEVDTAADGEEALELLreERPDLVLLDLMMPGMDgleLLRKLRELPPDIPVIVLTAKA 79

                         90
                 ....*....|....*...
gi 835226354  79 EPGLAEQAVRAGVAAYVV 96
Cdd:cd00156   80 DEEDAVRALELGADDYLV 97
 
Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-187 1.77e-52

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 166.29  E-value: 1.77e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835226354   1 MRVLVIDPDTARAALVAQGLE--GVQPLEVRRSAVYDEAEVMAFAPDVVVIAAESPDRDTLDSLQESSQGH--PVVMFVD 76
Cdd:COG3707    4 LRVLVVDDEPLRRADLREGLReaGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERpaPVILLTA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835226354  77 RSEPGLAEQAVRAGVAAYVVDGLAPNRVRSILDVAMSRFALTQQLRGDLAKAKADLESRKTVERAKGLLMKERGLDEDGA 156
Cdd:COG3707   84 YSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSEDEA 163

                        170       180       190
                 ....*....|....*....|....*....|.
gi 835226354 157 YRLLRKLAMDRGKPIGAVAADLLAFAGVLKG 187
Cdd:COG3707  164 YRLLRKQAMDRRVKLAEVAEAILAAAELLKG 194
ANTAR smart01012
ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found ...
 125-179 4.53e-15

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; The majority of the domain consists of a coiled-coil.


Pssm-ID: 198080 [Multi-domain]  Cd Length: 55  Bit Score: 65.96  E-value: 4.53e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 835226354   125 LAKAKADLESRKTVERAKGLLMKERGLDEDGAYRLLRKLAMDRGKPIGAVAADLL 179
Cdd:smart01012   1 LEQLREALESRKVIEQAKGILMERRGLSEEEAFELLRKLAMDRNVKLRDVAEAIV 55
ANTAR pfam03861
ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding ...
 132-176 4.95e-15

ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.


Pssm-ID: 427550 [Multi-domain]  Cd Length: 46  Bit Score: 65.82  E-value: 4.95e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 835226354  132 LESRKTVERAKGLLMKERGLDEDGAYRLLRKLAMDRGKPIGAVAA 176
Cdd:pfam03861   2 LESRKVIEQAKGILMERLGLSEDEAFRLLRKLSMDRNVKLREVAE 46
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-141 3.20e-07

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 49.19  E-value: 3.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835226354   1 MRVLVIDPDTARAALVAQGLEGvQPLEVRRSAVYDEAE--VMAFAPDVVVIAAESPDRD---TLDSLQESSQGHPVVMFV 75
Cdd:COG2204    3 ARILVVDDDPDIRRLLKELLER-AGYEVETAASGEEALalLREEPPDLVLLDLRMPGMDgleLLRELRALDPDLPVILLT 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 835226354  76 DRSEPGLAEQAVRAGVAAYVVDGLAPNRVRSILDVAMSRFALTQQLRGD---LAKAKADLESRKTVERA 141
Cdd:COG2204   82 GYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRRENAEDsglIGRSPAMQEVRRLIEKV 150
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-128 5.08e-04

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 38.41  E-value: 5.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835226354   1 MRVLVIDPDTARAALVAQGLEGVQPLEVRRSAvYDEAEVMAFA----PDVVVIAAESPDR---DTLDSLQESSQGHPVVM 73
Cdd:COG4565    4 IRVLIVEDDPMVAELLRRYLERLPGFEVVGVA-SSGEEALALLaehrPDLILLDIYLPDGdglELLRELRARGPDVDVIV 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 835226354  74 FVDRSEPGLAEQAVRAGVAAYVVDGLAPNRVRSILD-VAMSRFALTQQLRGDLAKA 128
Cdd:COG4565   83 ITAARDPETVREALRAGVVDYLIKPFTFERLREALErYLEYRRLLREDQEEDLPEA 138
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 4-96 9.80e-04

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 37.21  E-value: 9.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835226354   4 LVIDPDTARAALVAQGLEGvQPLEVRRSAVYDEAEVMA--FAPDVVVIAAESPDRD---TLDSLQESSQGHPVVMFVDRS 78
Cdd:cd00156    1 LIVDDDPAIRELLKSLLER-EGYEVDTAADGEEALELLreERPDLVLLDLMMPGMDgleLLRKLRELPPDIPVIVLTAKA 79

                         90
                 ....*....|....*...
gi 835226354  79 EPGLAEQAVRAGVAAYVV 96
Cdd:cd00156   80 DEEDAVRALELGADDYLV 97
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-111 3.62e-03

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 36.43  E-value: 3.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835226354   1 MRVLVIDPDTARAALVAQGLEGVQpLEVRrsAVYDEAEVMA----FAPDVVVIAAESPDRD---TLDSLQESSQGH--PV 71
Cdd:COG3706    2 ARILVVDDDPTNRKLLRRLLEAAG-YEVV--EAADGEEALEllqeHRPDLILLDLEMPDMDgleLCRRLRADPRTAdiPI 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 835226354  72 VMFVDRSEPGLAEQAVRAGVAAYVVDGLAPNRVRSILDVA 111
Cdd:COG3706   79 IFLTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLV 118
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-171 4.98e-03

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 36.47  E-value: 4.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835226354   1 MRVLVIDPDTARAALVAQGLEGvQPLEVRrsAVYDEAEVMAFA----PDVVVIAAESPDRD---TLDSLQESSQGHPVVM 73
Cdd:COG0745    2 PRILVVEDDPDIRELLADALER-EGYEVD--TAADGEEALELLeeerPDLILLDLMLPGMDgleVCRRLRARPSDIPIIM 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835226354  74 FVDRSEPGLAEQAVRAGVAAYVVDGLAPNRVRSILDVAMSRFALTQQLRGDLAKAKADLESRKtvERAKGLLMKErglde 153
Cdd:COG0745   79 LTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAEVLRVGDLLDLAAREVTRD--GEPVELTPKE----- 151

                        170
                 ....*....|....*...
gi 835226354 154 dgaYRLLRKLAMDRGKPI 171
Cdd:COG0745  152 ---FRLLELLMRNPGRVV 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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