NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|830197261|ref|XP_012588406|]
View 

PREDICTED: phosphatidylinositol-glycan-specific phospholipase D isoform X1 [Condylura cristata]

Protein Classification

integrin alpha( domain architecture ID 10467975)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Zn_dep_PLPC pfam00882
Zinc dependent phospholipase C;
28-220 5.91e-18

Zinc dependent phospholipase C;


:

Pssm-ID: 425927  Cd Length: 173  Bit Score: 82.38  E-value: 5.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830197261   28 THIEIGHRALEFLHLQVGSVnykELLLAHQDAYQAGTVFPDsfYPSICERGKFHDVSESTHWT---PFLNASIHYIREny 104
Cdd:pfam00882   1 THLTIASHALAVLPLLKKAR---KLLKLNKAALLLGSVAPD--IPYLFGFLPYSYLTHTHHWWetgDFILLLIKALRK-- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830197261  105 plpWKEDTEKLVAFLFGITSHMVADISWHSLGiqqgflRTMGAIDFHGSYSDAHSAGDFGGDVLSQSEfnfnylaRRWYV 184
Cdd:pfam00882  74 ---RKKGNLKLAAFLLGVLSHYLADVFTHSYG------VPLAGNGTFSGSLLQHVSYELGLDFLLLNY-------YRLEK 137

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 830197261  185 PVKDLLEIYKRLYGREVISKHVITDCSYLQFLEMHG 220
Cdd:pfam00882 138 EVDLLLLSVGDKDSNEALDELIKETLAAYLKEAFSG 173
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 378-435 2.05e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 57.00  E-value: 2.05e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 830197261   378 PYARLGWAMASA-DLNQDGYGDLVVGAPGYSHPGHiqVGRVYLIYGNDLGLPPVDLDLD 435
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 447-503 2.15e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 53.92  E-value: 2.15e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 830197261   447 PSGRFGSALA-VLDFNQDGLPDLAVGAPSVGSEKLTykGKVYIYFGCKQG-RMSSSPNI 503
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGET--GAVYVYFGSSGGgNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 515-551 3.20e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 41.34  E-value: 3.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 830197261  515 GWTLLAADMNGDSKPDLVIGSPFapGGGKQKGIVAAF 551
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPG--EGGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 719-762 1.65e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 36.72  E-value: 1.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 830197261  719 FGGVLHLSDLDNDGLDEIIMAAPLRTadmtsgliGGEDGRVYVY 762
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEG--------GAGAGAVYVL 36
 
Name Accession Description Interval E-value
Zn_dep_PLPC pfam00882
Zinc dependent phospholipase C;
28-220 5.91e-18

Zinc dependent phospholipase C;


Pssm-ID: 425927  Cd Length: 173  Bit Score: 82.38  E-value: 5.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830197261   28 THIEIGHRALEFLHLQVGSVnykELLLAHQDAYQAGTVFPDsfYPSICERGKFHDVSESTHWT---PFLNASIHYIREny 104
Cdd:pfam00882   1 THLTIASHALAVLPLLKKAR---KLLKLNKAALLLGSVAPD--IPYLFGFLPYSYLTHTHHWWetgDFILLLIKALRK-- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830197261  105 plpWKEDTEKLVAFLFGITSHMVADISWHSLGiqqgflRTMGAIDFHGSYSDAHSAGDFGGDVLSQSEfnfnylaRRWYV 184
Cdd:pfam00882  74 ---RKKGNLKLAAFLLGVLSHYLADVFTHSYG------VPLAGNGTFSGSLLQHVSYELGLDFLLLNY-------YRLEK 137

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 830197261  185 PVKDLLEIYKRLYGREVISKHVITDCSYLQFLEMHG 220
Cdd:pfam00882 138 EVDLLLLSVGDKDSNEALDELIKETLAAYLKEAFSG 173
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 378-435 2.05e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 57.00  E-value: 2.05e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 830197261   378 PYARLGWAMASA-DLNQDGYGDLVVGAPGYSHPGHiqVGRVYLIYGNDLGLPPVDLDLD 435
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 447-503 2.15e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 53.92  E-value: 2.15e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 830197261   447 PSGRFGSALA-VLDFNQDGLPDLAVGAPSVGSEKLTykGKVYIYFGCKQG-RMSSSPNI 503
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGET--GAVYVYFGSSGGgNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 451-489 9.04e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.74  E-value: 9.04e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 830197261  451 FGSALAVLDFNQDGLPDLAVGAPsvgSEKLTYKGKVYIY 489
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAP---GEGGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 383-420 3.13e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.12  E-value: 3.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 830197261  383 GWAMASADLNQDGYGDLVVGAPGYSHPGhiqVGRVYLI 420
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 515-551 3.20e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 41.34  E-value: 3.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 830197261  515 GWTLLAADMNGDSKPDLVIGSPFapGGGKQKGIVAAF 551
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPG--EGGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 719-762 1.65e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 36.72  E-value: 1.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 830197261  719 FGGVLHLSDLDNDGLDEIIMAAPLRTadmtsgliGGEDGRVYVY 762
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEG--------GAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 511-565 6.51e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 35.81  E-value: 6.51e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 830197261   511 YCNLGWTL-LAADMNGDSKPDLVIGSPFApGGGKQKGIVAAFYSDPSWSDKEQLNV 565
Cdd:smart00191   2 GSYFGYSVaGVGDVNGDGYPDLLVGAPRA-NDAGETGAVYVYFGSSGGGNSIPLQN 56
 
Name Accession Description Interval E-value
Zn_dep_PLPC pfam00882
Zinc dependent phospholipase C;
28-220 5.91e-18

Zinc dependent phospholipase C;


Pssm-ID: 425927  Cd Length: 173  Bit Score: 82.38  E-value: 5.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830197261   28 THIEIGHRALEFLHLQVGSVnykELLLAHQDAYQAGTVFPDsfYPSICERGKFHDVSESTHWT---PFLNASIHYIREny 104
Cdd:pfam00882   1 THLTIASHALAVLPLLKKAR---KLLKLNKAALLLGSVAPD--IPYLFGFLPYSYLTHTHHWWetgDFILLLIKALRK-- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830197261  105 plpWKEDTEKLVAFLFGITSHMVADISWHSLGiqqgflRTMGAIDFHGSYSDAHSAGDFGGDVLSQSEfnfnylaRRWYV 184
Cdd:pfam00882  74 ---RKKGNLKLAAFLLGVLSHYLADVFTHSYG------VPLAGNGTFSGSLLQHVSYELGLDFLLLNY-------YRLEK 137

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 830197261  185 PVKDLLEIYKRLYGREVISKHVITDCSYLQFLEMHG 220
Cdd:pfam00882 138 EVDLLLLSVGDKDSNEALDELIKETLAAYLKEAFSG 173
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 378-435 2.05e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 57.00  E-value: 2.05e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 830197261   378 PYARLGWAMASA-DLNQDGYGDLVVGAPGYSHPGHiqVGRVYLIYGNDLGLPPVDLDLD 435
Cdd:smart00191   1 PGSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 447-503 2.15e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 53.92  E-value: 2.15e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 830197261   447 PSGRFGSALA-VLDFNQDGLPDLAVGAPSVGSEKLTykGKVYIYFGCKQG-RMSSSPNI 503
Cdd:smart00191   1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGET--GAVYVYFGSSGGgNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 451-489 9.04e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.74  E-value: 9.04e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 830197261  451 FGSALAVLDFNQDGLPDLAVGAPsvgSEKLTYKGKVYIY 489
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAP---GEGGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 383-420 3.13e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.12  E-value: 3.13e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 830197261  383 GWAMASADLNQDGYGDLVVGAPGYSHPGhiqVGRVYLI 420
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 459-533 1.45e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 46.06  E-value: 1.45e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 830197261  459 DFNQDGLPDLAVGAPsvgsekltykGKVYIYFGCKQGRMSSSPNITISCQDvycnLGWTLLAADMNGDSKPDLVI 533
Cdd:pfam13517   1 DLDGDGKLDLVVAND----------GGLRLYLNNGDGTFTFITSVSLGGGG----GGLSVAVGDLDGDGRLDLLV 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 515-551 3.20e-05

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 41.34  E-value: 3.20e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 830197261  515 GWTLLAADMNGDSKPDLVIGSPFapGGGKQKGIVAAF 551
Cdd:pfam01839   2 GYSVAVGDLNGDGYADLAVGAPG--EGGAGAGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 390-470 1.38e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 40.67  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830197261  390 DLNQDGYGDLVVGAPGYShpghiqvgRVYLIYGNDLGLPPVDLDLdkeahgilegfqPSGRFGSALAVLDFNQDGLPDLA 469
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL--------RLYLNNGDGTFTFITSVSL------------GGGGGGLSVAVGDLDGDGRLDLL 60


                  .
gi 830197261  470 V 470
Cdd:pfam13517  61 V 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 719-762 1.65e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 36.72  E-value: 1.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 830197261  719 FGGVLHLSDLDNDGLDEIIMAAPLRTadmtsgliGGEDGRVYVY 762
Cdd:pfam01839   1 FGYSVAVGDLNGDGYADLAVGAPGEG--------GAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 511-565 6.51e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 35.81  E-value: 6.51e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 830197261   511 YCNLGWTL-LAADMNGDSKPDLVIGSPFApGGGKQKGIVAAFYSDPSWSDKEQLNV 565
Cdd:smart00191   2 GSYFGYSVaGVGDVNGDGYPDLLVGAPRA-NDAGETGAVYVYFGSSGGGNSIPLQN 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH