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Conserved domains on  [gi|829625085|gb|AKL80892|]
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wingless, partial [Erebia theano]

Protein Classification

wnt family protein( domain architecture ID 1562737)

wnt family protein may function in development and differentiation

Gene Ontology:  GO:0016055|GO:0005102|GO:0005576
PubMed:  22952392|20477987|8167409
SCOP:  4005649|4007801

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wnt super family cl38924
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 1-126 1.15e-59

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


The actual alignment was detected with superfamily member cd19333:

Pssm-ID: 393294  Cd Length: 311  Bit Score: 185.63  E-value: 1.15e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   1 MRLPTFRSVGDALKDGFDGASRVMMPNTEleapaqrndaapHRVPRRDRYRFQLRPHNPDHKTPGVKDLVYLESSPGFCE 80
Cdd:cd19333  174 MRLPTFRTVGDRLKDRFDGASRVAYGNNG------------NNRGSRRAKKFLLEPENPNHKPPTSKDLVYFEESPNFCE 241

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 829625085  81 KNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19333  242 KNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCN 287
 
Name Accession Description Interval E-value
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 1-126 1.15e-59

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 185.63  E-value: 1.15e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   1 MRLPTFRSVGDALKDGFDGASRVMMPNTEleapaqrndaapHRVPRRDRYRFQLRPHNPDHKTPGVKDLVYLESSPGFCE 80
Cdd:cd19333  174 MRLPTFRTVGDRLKDRFDGASRVAYGNNG------------NNRGSRRAKKFLLEPENPNHKPPTSKDLVYFEESPNFCE 241

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 829625085  81 KNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19333  242 KNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCN 287
WNT1 smart00097
found in Wnt-1;
1-126 5.35e-51

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 163.26  E-value: 5.35e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085     1 MRLPTFRSVGDALKDGFDGASRVMMpnteleapaqrndaaphrvpRRDRYRFQLRPHNPDHKTPGVKDLVYLESSPGFCE 80
Cdd:smart00097 176 LQLPDFRKVGDYLKEKYDGASEVEV--------------------DKRGTNKAPVPKNSTFKPPTETDLVYLESSPDFCE 235

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 829625085    81 KNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:smart00097 236 KNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCN 281
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-126 5.16e-50

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 160.80  E-value: 5.16e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085    1 MRLPTFRSVGDALKDGFDGASRVMMPNTEleapaqrndaaphrvprrdryRFQLRPHNPDHKTPGVKDLVYLESSPGFCE 80
Cdd:pfam00110 179 KALPPFREVGDRLKEKYDGAVKVNRRRNK---------------------RGRLVPRNSRFKPPTKNDLVYLEKSPDYCE 237

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 829625085   81 KNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:pfam00110 238 RNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCN 283
 
Name Accession Description Interval E-value
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 1-126 1.15e-59

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 185.63  E-value: 1.15e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   1 MRLPTFRSVGDALKDGFDGASRVMMPNTEleapaqrndaapHRVPRRDRYRFQLRPHNPDHKTPGVKDLVYLESSPGFCE 80
Cdd:cd19333  174 MRLPTFRTVGDRLKDRFDGASRVAYGNNG------------NNRGSRRAKKFLLEPENPNHKPPTSKDLVYFEESPNFCE 241

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 829625085  81 KNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19333  242 KNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCN 287
WNT1 smart00097
found in Wnt-1;
1-126 5.35e-51

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 163.26  E-value: 5.35e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085     1 MRLPTFRSVGDALKDGFDGASRVMMpnteleapaqrndaaphrvpRRDRYRFQLRPHNPDHKTPGVKDLVYLESSPGFCE 80
Cdd:smart00097 176 LQLPDFRKVGDYLKEKYDGASEVEV--------------------DKRGTNKAPVPKNSTFKPPTETDLVYLESSPDFCE 235

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 829625085    81 KNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:smart00097 236 KNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCN 281
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-126 5.16e-50

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 160.80  E-value: 5.16e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085    1 MRLPTFRSVGDALKDGFDGASRVMMPNTEleapaqrndaaphrvprrdryRFQLRPHNPDHKTPGVKDLVYLESSPGFCE 80
Cdd:pfam00110 179 KALPPFREVGDRLKEKYDGAVKVNRRRNK---------------------RGRLVPRNSRFKPPTKNDLVYLEKSPDYCE 237

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 829625085   81 KNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:pfam00110 238 RNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCN 283
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 2-126 9.43e-46

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 150.07  E-value: 9.43e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   2 RLPTFRSVGDALKDGFDGASRVMMPNTeleapaqrndaaphrvprrdryRFQLRPHNPDHKTPGVKDLVYLESSPGFCEK 81
Cdd:cd19338  184 KMPPFREVGDRLKERFDGAIKVKGSND----------------------GKSLIPEGKTIKPPTKEDLVYLEESPDFCEP 241

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 829625085  82 NPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19338  242 NKKTGSLGTRGRECNRTSMGVDGCDLLCCGRGYQTEVRVVEENCN 286
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 3-126 3.39e-41

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 138.22  E-value: 3.39e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   3 LPTFRSVGDALKDGFDGAsrvmmpnTELEapaqrndaaphrvPRRDRYRFQLRPHNPDHKTPGVKDLVYLESSPGFCEKN 82
Cdd:cd19336  183 MPTFREVGNILKEKFDGA-------TEVQ-------------QKRIGSRPVLVPKNPQFKPHTDADLVYLDSSPDFCEPD 242

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 829625085  83 PRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19336  243 PKTGSLGTHGRVCNKTSKAIDGCDLLCCGRGYVTRTEEVVERCS 286
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 1-126 7.89e-39

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 131.65  E-value: 7.89e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   1 MRLPTFRSVGDALKDGFDGASRVMMPNteleapaqrndaaphrvprrDRYRFQLRPHNPDHKTPGVKDLVYLESSPGFCE 80
Cdd:cd13113  160 RQLPSFREIGDYLKEKYDNAVKVKLNN--------------------NGSGLRLVPKRSRFRSPTETDLVYLEESPDYCE 219

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 829625085  81 KNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd13113  220 PNPTLGSLGTAGRECNPTSPGPDSCELLCCGRGYRTETEIVTEKCN 265
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 3-126 3.66e-37

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 128.18  E-value: 3.66e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   3 LPTFRSVGDALKDGFDGASRVMmpnteleapaqrndaaPHRVPRRDRYRFQLRPHNPDHKTPGVKDLVYLESSPGFCEKN 82
Cdd:cd19339  182 LPSFREIGDYLKKKYERARRVE----------------PVRGRRRRRPTFLKLKISRKYKKPRPRDLVYLEKSPNYCEKD 245

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 829625085  83 PRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19339  246 PLTGSLGTVGRRCNRTSTGTDGCDLMCCGRGYNTHQYTKTWQCN 289
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 3-126 3.94e-35

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 122.88  E-value: 3.94e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   3 LPTFRSVGDALKDGFDGAS--RVMMpnteleapaqrndaapHRVPRRdRYRFqLRPHNPDHKTPGVKDLVYLESSPGFCE 80
Cdd:cd19335  183 QPDFRKIGDYLKDKYDSASemVVER----------------HRESRG-WVET-LRPKYKLFKPPTERDLIYYEESPNFCE 244

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 829625085  81 KNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19335  245 PNPETGSFGTRGRECNVTSHGIDGCDLLCCGRGYNTRTEKRTEKCH 290
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 4-126 7.32e-35

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 121.99  E-value: 7.32e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   4 PTFRSVGDALKDGFDGASRVMMPNteleapaqRNDAAPHRVPRRDRyrfqlrphnpDHKTPGVKDLVYLESSPGFCEKNP 83
Cdd:cd19342  188 PDFREVGDILKEKYDHATLVDQSN--------LNNGARRRRLTRRK----------RRRRPPKTDLVYYERSPNFCEADP 249

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 829625085  84 RLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19342  250 SLDSPGTRGRVCNKTSTGPDSCDSLCCGRGYNTVRQTRTERCN 292
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 1-126 6.20e-34

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 119.66  E-value: 6.20e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   1 MRLPTFRSVGDALKDGFDGASRVmmpnteleapaqrndaaphRVPRRDRYRFQLrphNPDHKTPGVKDLVYLESSPGFCE 80
Cdd:cd19337  186 RQLAPFREVGDRLKDKYDGAVKV-------------------KLNRRGTLLRRR---NSRFNKPTKDDLVYLDDSPDYCE 243

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 829625085  81 KNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19337  244 RNPKTGSLGTKGRECNKTSSGTDGCELLCCGRGYNTKKVEVVERCH 289
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 2-126 8.81e-33

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 116.59  E-value: 8.81e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   2 RLPTFRSVGDALKDGFDGASRVmmpnteleapaqrndaaphrVPRRDRYRFQLRPHNPDHKTPGVKDLVYLESSPGFCEK 81
Cdd:cd19343  177 ALPDLSEVASRLKRKYARAVEV--------------------VSRKVGSRRKLVPKSLKVRPYTKDDLIYLTKSPDYCLP 236

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 829625085  82 NPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19343  237 DEKLGSLGTRGRECNKTSVGSDSCDSMCCGRGYRTYTVEVVERCH 281
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 1-126 3.46e-31

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 112.33  E-value: 3.46e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   1 MRLPTFRSVGDALKDGFDGASRVMmpnteleapaqrNDAAPHRVPRRDRYRfqlrphnpdHKTP-GVKDLVYLESSPGFC 79
Cdd:cd19344  177 KTMPSFEEVGDFLKQKYENSIQIA------------TKKSKRRLRRRERRK---------RKVPiSKDELVYIHKSPNYC 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 829625085  80 EKNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19344  236 VRDPKKGILGTSGRECNRTSTGPDSCDLLCCGRGYNTQVVRHVERCN 282
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 3-126 6.49e-31

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 111.66  E-value: 6.49e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   3 LPTFRSVGDALKDGFDGASRVMM-PNTELEAPAQRNdaapHRVPRRDryrfqlrphnpdhktpgvkDLVYLESSPGFCEK 81
Cdd:cd19334  189 LAEFREVGDYLREKYDGAVQVTMnQSGTNLLAANKG----HKKPTRS-------------------DLVYFESSPDYCVP 245

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 829625085  82 NPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19334  246 NPETGSLGTAGRVCNKTSTGTDGCDIMCCGRGYDTTRVRRTTKCN 290
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 3-126 5.88e-24

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 93.58  E-value: 5.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   3 LPTFRSVGDALKDGFDGASRVmmpnteleapaqrndaAPHRVPRRDRYRFqLRPHNP-DHKTPGVKDLVYLESSPGFCEK 81
Cdd:cd19349  187 LPKFRELGYILKDKYNEAVHV----------------EPVRASRNKRPTF-LKIKKPlSYRKPMDTDLVYIEKSPNYCEE 249

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 829625085  82 NPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19349  250 DPVTGSVGTQGRMCNKTAQQNNGCDLMCCGRGYNTHQYSRVWQCN 294
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 1-126 1.98e-23

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 92.05  E-value: 1.98e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   1 MRLPTFRSVGDALKDGFDGASrVMMPNTeleapaqrndaaphrvprrdryRFQLRPHNPDHKTPGVKDLVYLESSPGFCE 80
Cdd:cd19347  186 LQLADFRKVGDALKEKYDSAA-AMKLNS----------------------RGKLVQVNSRFNPPTTLDLVYIDPSPDYCV 242

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 829625085  81 KNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19347  243 RNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCH 288
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 1-126 2.23e-23

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 91.97  E-value: 2.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   1 MRLPTFRSVGDALKDGFDgasrvmmpnteleapaqrnDAAPHRVPRRDRYRFQLRPHNPdhktPGVKDLVYLESSPGFCE 80
Cdd:cd19348  186 LQLADFRKVGDLLKEKYD-------------------SAAAMRINRKGKLELVNSRFNP----PTAEDLVYIDPSPDYCL 242

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 829625085  81 KNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19348  243 RNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQVERCH 288
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 4-126 1.21e-22

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 89.66  E-value: 1.21e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   4 PTFRSVGDALKDGFDGASrvmmpnteLEAPAQRNDAAPHRVPRRDRYRfqlrphnpdhktPGVKDLVYLESSPGFCEKNP 83
Cdd:cd19355  176 PEFRTVGSLLKDRFYVAT--------LIKPHNRNTGQLEPGHAPHRRR------------ASINDLVYFEKSPDFCEREP 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 829625085  84 RLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19355  236 RLDSAGTQGRICNKTSPGMDNCESLCCGRGHNILRQTRSERCN 278
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 3-126 1.95e-22

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 89.68  E-value: 1.95e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   3 LPTFRSVGDALKDGFdgasrvmmpnteleapaqrNDAAPHRVPRRDRYR---FQLRPHNPDHKTPGVKDLVYLESSPGFC 79
Cdd:cd19350  187 LPKFREIGYVLKEKY-------------------NAAVQVEVVRASRLRqptFLKIKKRRSYQKPMETDLVYIERSPNYC 247

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 829625085  80 EKNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19350  248 EEDAATGSVGTQGRLCNRTSPHTDGCDLMCCGRGYNTHQYTKVWQCN 294
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 4-126 1.05e-20

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 84.55  E-value: 1.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   4 PTFRSVGDALKDGFDGASRVMMPNteleapaqRNDAAPHrvPRRDRYRFQlrphnpdhktpgvKDLVYLESSPGFCEKNP 83
Cdd:cd19356  176 PEFRLVGALLREKFQRAIFINSHN--------KNSGVFL--PRLRPRRLA-------------RELVYFEKSPDFCERDP 232

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 829625085  84 RLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19356  233 AVDSPGTQGRICNKTSPGMDGCGSLCCGRGHNILKQTRSERCH 275
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 2-126 1.89e-19

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 81.18  E-value: 1.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   2 RLPTFRSVGDALKDGFDGASRVMMPNTEleapaqrndaaphrVPRRDRYRFQLRPHNPDHKTPGVKDLVYLESSPGFCEK 81
Cdd:cd19341  171 QLAPFNEIGKILKRKYEKAVKVVSENNA--------------ATGGSQLRKGKSGSVKKKSRPRRKDLVYLEKSPSFCRS 236

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 829625085  82 NPRlgIPGTHGRACNDTsigvDGCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19341  237 TRY--SPGTKGRRCLKG----DNCDTLCCGRGYNTQSEVVVKPCK 275
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 1-125 7.78e-19

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 79.59  E-value: 7.78e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   1 MRLPTFRSVGDALKDGFDGASRVMMpnteleapaqrndaaphrvprrDRYRFQLRPHNPDHKTPGVKDLVYLESSPGFCE 80
Cdd:cd19345  187 LAMADFRKTGDYLRKKYNGAIQVVM----------------------NQDGTGFTVANKHFKKPTKNDLVYFENSPDYCV 244

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 829625085  81 KNPRLGIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERC 125
Cdd:cd19345  245 RDRDAGSLGTAGRVCNRTSRGMDGCEVMCCGRGYDTSRVGRMTKC 289
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 6-125 4.75e-17

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 74.96  E-value: 4.75e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   6 FRSVGDALKDGFDGASRVMMpnteleapaqRNDAAPHRVPRRDryrfqlrphnpdHKTPGVKDLVYLESSPGFCEKNPRL 85
Cdd:cd19346  192 FRKTGDYLRKRYNGAVQVTM----------NQDGTGFTVANKN------------FRKATKTDLVYFENSPDYCVMDKSA 249

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 829625085  86 GIPGTHGRACNDTSIGVDGCDLMCCGRGYRTETMFVVERC 125
Cdd:cd19346  250 GSLGTAGRVCNKSSRGTDGCEVMCCGRGYDTTRVTRVTKC 289
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 2-126 1.70e-14

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 67.62  E-value: 1.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   2 RLPTFRSVGDALKDGFDGASRVM------MPNTELEAPAQRNDAAPHRVPRrdryrfqlrphnpdhktpgVKDLVYLESS 75
Cdd:cd19354  168 QLSPFHETGRLLKLKYENAVKVHsvtndaTGETELWSPERHGHTLKGHSPR-------------------STDLVYLEDS 228

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 829625085  76 PGFCEknPRLGIPGTHGRACN-DTSigvdgCDLMCCGRGYRTETMFVVERCN 126
Cdd:cd19354  229 PSFCR--PSKYSPGTAGRTCSrETN-----CDSLCCGRGYNTQSRLVTFSCH 273
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 1-126 7.47e-12

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 60.38  E-value: 7.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   1 MRLPTFRSVGDALKDGFDGASRVMMPNTELEapaqrndaaphrvPRRDRYRFQLRPHNPDhktpgvkDLVYLESSPGFCE 80
Cdd:cd19340  164 MQLAPFREIGTDLKRKYDRAVRVDYENGGLR-------------ETNGSRAIKLLNIKKN-------DLVYLEKSPNYCR 223

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 829625085  81 KNPRLGIPGTHGRACN-DTSIGVDGCDLMCCGR-----GY--RTETMFVVERCN 126
Cdd:cd19340  224 ANVTLGWPGTLGRQCSrDKKESVSRWERKSCRRlcracGLkvRKKVVEVTSSCN 277
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 2-125 3.12e-09

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 53.12  E-value: 3.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   2 RLPTFRSVGDALKDGFDGASRVMMPNTELEAPAqrnDAAPHRVPRrdryrfqlrPHNPDhKTPGVKDLVYLESSPGFCEK 81
Cdd:cd19353  169 QLSPFHEIGKQLKQKYETSLKVGSTTNEATGEG---DISPPKKSG---------AGHSD-QIPRTTDLVYIDDSPSFCLM 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 829625085  82 NpRLGiPGTHGRACNDTSigvdGCDLMCCGRGYRTETMFVVERC 125
Cdd:cd19353  236 S-RFS-PGTSGRRCYKDK----NCESICCGRGHNTQSRVVTRPC 273
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 1-126 5.38e-09

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 52.60  E-value: 5.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   1 MRLPTFRSVGDALKDGFDGASRVMMPNTELEApaqrNDAAPHRVPRRDRYrfqlrphNPDHKTpgvkDLVYLESSPGFCE 80
Cdd:cd19351  166 LQLADFREIGNYLKVKHDQALKLEMDKRRMRA----GNSADNRGAIAEAF-------GSVAET----ELIYLEDSPDYCT 230

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 829625085  81 KNPRLGIPGTHGRACNDTSIGVD-----GCDLMCCGRGYRTET--MFVVERCN 126
Cdd:cd19351  231 KNASLGLQGTEGRECLQSGKNLSqwerrSCRRLCTECGLRVEErrTEVVSSCN 283
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 1-126 1.06e-07

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 48.87  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 829625085   1 MRLPTFRSVGDALKDGFDGASRVMMPNTELEAPAQRNDAAphrvprrDRYRfqlrphnpdhkTPGVKDLVYLESSPGFCE 80
Cdd:cd19352  167 LQLPEFREVGNYLKEKYHRALKVDLLQGAGNSAASRGAIA-------ETFR-----------SISKKELVHLEDSPDYCL 228

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 829625085  81 KNPRLGIPGTHGRACNDTSIGVD-----GCDLMC--CGRGYRTETMFVVERCN 126
Cdd:cd19352  229 ENKTLGLLGTEGRECLKRGKALSkwekrSCRRLCgdCGLAVEERRAEMVSSCN 281
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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