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Conserved domains on  [gi|827623882|gb|AKJ93934|]
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histidine kinase [Thioalkalivibrio versutus]

Protein Classification

3',5'-cyclic nucleotide phosphodiesterase; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; GAF domain-containing hybrid sensor histidine kinase/response regulator; GAF domain-containing protein; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing sensor histidine kinase; hybrid sensor histidine kinase/response regulator; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing protein; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing hybrid sensor histidine kinase/response regulator; GAF domain-containing protein; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing sensor histidine kinase; hybrid sensor histidine kinase/response regulator; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing protein; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing sensor histidine kinase; hybrid sensor histidine kinase/response regulator; hybrid sensor histidine kinase/response regulator; sensor histidine kinase; GAF domain-containing protein; GAF domain-containing sensor histidine kinase; GGDEF domain-containing protein; GGDEF domain-containing protein; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; GGDEF domain-containing protein; sensor domain-containing diguanylate cyclase; sensor domain-containing diguanylate cyclase; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; ATP-binding protein; sensor histidine kinase; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; ATP-binding protein; sensor histidine kinase; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; sensor histidine kinase; sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; GAF domain-containing protein; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; sensor histidine kinase; GAF domain-containing sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; ATP-binding protein; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing protein; PAS domain-containing sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; sensor histidine kinase; ATP-binding prote( domain architecture ID 11466476)

3',5'-cyclic nucleotide phosphodiesterase with one or more N-terminal GAF domains, may show activity towards 3',5'-cyclic GMP and/or 3',5'-cyclic AMP; GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; ATPase similar to histidine kinase domains; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; ATPase similar to histidine kinase domains; GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase similar to Staphylococcus aureus VraS and Bacillus subtilis DesK; uncharacterized GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; two-component sensor histidine kinase similar to Staphylococcus aureus VraS and Bacillus subtilis DesK; ATPase similar to histidine kinase domains; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; two-component sensor histidine kinase similar to Staphylococcus aureus VraS and Bacillus subtilis DesK; GAF domain-containing sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to external signals; contains one or more GAF sensor domain(s); ATPase similar to histidine kinase domains; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; uncharacterized GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; two-component sensor histidine kinase containing a GAF sensor domain; may also contain a PAS sensor and/or ligand-binding domain; ATPase similar to histidine kinase domains; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; uncharacterized GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; two-component sensor histidine kinase containing a GAF sensor domain; may also contain a PAS sensor and/or ligand-binding domain; two-component sensor histidine kinase with GAF and/or PAS sensor domain(s), functions as a protein kinase that phosphorylates a target protein in response to various signals; ATPase similar to histidine kinase domains; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; uncharacterized GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; two-component sensor histidine kinase containing a GAF sensor domain; may also contain a PAS sensor and/or ligand-binding domain; ATPase similar to histidine kinase domains; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; uncharacterized GAF domain-containing protein; the GAF domain is a small-molecule-binding domain found in phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; two-component sensor histidine kinase containing a GAF sensor domain; may also contain a PAS sensor and/or ligand-binding domain; two-component sensor histidine kinase with GAF and/or PAS sensor domain(s), functions as a protein kinase that phosphorylates a target protein in response to various signals; GAF domain-containing protein similar to Mycobacterium phage L5 Gene 84 protein; the GAF domain is a small-molecule-binding domain found in proteins including phytochromes, adenylyl and guanylyl cyclases, and cGMP-specific phosphodiesterases; sensor histidine kinase containing a GAF domain; two-component sensor histidine kinase; two-component sensor histidine kinase with a PAS sensor and-or ligand binding domain, similar to Escherichia coli nitrogen regulator II, Azorhizobium caulinodans FixL and Streptococcus mutans CovS, having a variety of functions; GAF domain-containing protein similar to Mycobact

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PtsP COG3605
Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];
10-186 1.01e-22

Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];


:

Pssm-ID: 442824 [Multi-domain]  Cd Length: 188  Bit Score: 91.11  E-value: 1.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827623882  10 ERLMELAHFVEEAESLEKGLAGLAALVSHAMECERCSIMLLkpDPDGGaaRLRVQAHHGYLPDHAYDVRQPLGSGISGRV 89
Cdd:COG3605    4 KALRRISEAVASALDLDEALDRIVRRIAEALGVDVCSIYLL--DPDGG--RLELRATEGLNPEAVGKVRLPLGEGLVGLV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827623882  90 ASARKGLLIRDLHASDLAAEARRAEGAGPVDVIAVPVILEGDLLGVINIDSPEGRgRLTQEDLRRALILALVVAKSVLVH 169
Cdd:COG3605   80 AERGEPLNLADAASHPRFKYFPETGEEGFRSFLGVPIIRRGRVLGVLVVQSREPR-EFTEEEVEFLVTLAAQLAEAIANA 158

                        170
                 ....*....|....*..
gi 827623882 170 RLKGLLRTSFTQMALAR 186
Cdd:COG3605  159 ELLGELRAALAELSLAR 175
 
Name Accession Description Interval E-value
PtsP COG3605
Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];
10-186 1.01e-22

Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];


Pssm-ID: 442824 [Multi-domain]  Cd Length: 188  Bit Score: 91.11  E-value: 1.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827623882  10 ERLMELAHFVEEAESLEKGLAGLAALVSHAMECERCSIMLLkpDPDGGaaRLRVQAHHGYLPDHAYDVRQPLGSGISGRV 89
Cdd:COG3605    4 KALRRISEAVASALDLDEALDRIVRRIAEALGVDVCSIYLL--DPDGG--RLELRATEGLNPEAVGKVRLPLGEGLVGLV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827623882  90 ASARKGLLIRDLHASDLAAEARRAEGAGPVDVIAVPVILEGDLLGVINIDSPEGRgRLTQEDLRRALILALVVAKSVLVH 169
Cdd:COG3605   80 AERGEPLNLADAASHPRFKYFPETGEEGFRSFLGVPIIRRGRVLGVLVVQSREPR-EFTEEEVEFLVTLAAQLAEAIANA 158

                        170
                 ....*....|....*..
gi 827623882 170 RLKGLLRTSFTQMALAR 186
Cdd:COG3605  159 ELLGELRAALAELSLAR 175
GAF smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ...
 32-176 7.51e-13

Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.


Pssm-ID: 214500 [Multi-domain]  Cd Length: 149  Bit Score: 63.94  E-value: 7.51e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827623882    32 LAALVSHAMECERCSIMLLkpDPDGGAARLRVQAHHGYLPDHAydVRQPLGSGISGRVASARKGLLIRDLHASDLAAEAR 111
Cdd:smart00065   9 ILEELRQLLGADRVLIYLV--DENDRGELVLVAADGLTLPTLG--IRFPLDEGLAGRVAETGRPLNIPDVEADPLFAEDL 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 827623882   112 RAEGAGPVDVIAVPVILEGDLLGVINIDSPEGRGRLTQEDLRRALILALVVAKSVLVHRLKGLLR 176
Cdd:smart00065  85 LGRYQGVRSFLAVPLVADGELVGVLALHNKKSPRPFTEEDEELLQALANQLAIALANAQLYEELR 149
GAF pfam01590
GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl ...
 24-166 3.18e-05

GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54. This domain can bind biliverdine and phycocyanobilin (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460259 [Multi-domain]  Cd Length: 133  Bit Score: 42.47  E-value: 3.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827623882   24 SLEKGLAGLAALVSHAMECERCSIMLLKPDpdgGAARLRVQAHHGYLPDHAYDVrqplgsGISGRVASARKGLLIRDLHA 103
Cdd:pfam01590   1 DLEEILQTILEELRELLGADRCALYLPDAD---GLEYLPPGARWLKAAGLEIPP------GTGVTVLRTGRPLVVPDAAG 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 827623882  104 SD-LAAEARRAEGAGPVDVIAVPVILEGDLLGVINIDSPegRGRLTQEDLRRALILALVVAKSV 166
Cdd:pfam01590  72 DPrFLDPLLLLRNFGIRSLLAVPIIDDGELLGVLVLHHP--RPPFTEEELELLEVLADQVAIAL 133
 
Name Accession Description Interval E-value
PtsP COG3605
Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];
10-186 1.01e-22

Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms];


Pssm-ID: 442824 [Multi-domain]  Cd Length: 188  Bit Score: 91.11  E-value: 1.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827623882  10 ERLMELAHFVEEAESLEKGLAGLAALVSHAMECERCSIMLLkpDPDGGaaRLRVQAHHGYLPDHAYDVRQPLGSGISGRV 89
Cdd:COG3605    4 KALRRISEAVASALDLDEALDRIVRRIAEALGVDVCSIYLL--DPDGG--RLELRATEGLNPEAVGKVRLPLGEGLVGLV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827623882  90 ASARKGLLIRDLHASDLAAEARRAEGAGPVDVIAVPVILEGDLLGVINIDSPEGRgRLTQEDLRRALILALVVAKSVLVH 169
Cdd:COG3605   80 AERGEPLNLADAASHPRFKYFPETGEEGFRSFLGVPIIRRGRVLGVLVVQSREPR-EFTEEEVEFLVTLAAQLAEAIANA 158

                        170
                 ....*....|....*..
gi 827623882 170 RLKGLLRTSFTQMALAR 186
Cdd:COG3605  159 ELLGELRAALAELSLAR 175
GAF smart00065
Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these ...
 32-176 7.51e-13

Domain present in phytochromes and cGMP-specific phosphodiesterases; Mutations within these domains in PDE6B result in autosomal recessive inheritance of retinitis pigmentosa.


Pssm-ID: 214500 [Multi-domain]  Cd Length: 149  Bit Score: 63.94  E-value: 7.51e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827623882    32 LAALVSHAMECERCSIMLLkpDPDGGAARLRVQAHHGYLPDHAydVRQPLGSGISGRVASARKGLLIRDLHASDLAAEAR 111
Cdd:smart00065   9 ILEELRQLLGADRVLIYLV--DENDRGELVLVAADGLTLPTLG--IRFPLDEGLAGRVAETGRPLNIPDVEADPLFAEDL 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 827623882   112 RAEGAGPVDVIAVPVILEGDLLGVINIDSPEGRGRLTQEDLRRALILALVVAKSVLVHRLKGLLR 176
Cdd:smart00065  85 LGRYQGVRSFLAVPLVADGELVGVLALHNKKSPRPFTEEDEELLQALANQLAIALANAQLYEELR 149
MsrC COG1956
GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, ...
 8-153 8.99e-11

GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, Signal transduction mechanisms];


Pssm-ID: 441559 [Multi-domain]  Cd Length: 156  Bit Score: 58.30  E-value: 8.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827623882   8 FDERLMELAHFVEEAESLEKGLAGLAALVSHAME-CERCSIMLLKPDPDggaarLRVQAHHGyLPDHaydVRQPLGSGIS 86
Cdd:COG1956    9 YDELLAQLSALLAGETDLIANLANISALLFEALPdYNWVGFYLVDGGGE-----LVLGPFQG-PPAC---TRIPFGKGVC 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 827623882  87 GRVASARKGLLIRDLH------ASDlaaearraegAGPVDVIAVPVILEGDLLGVINIDSPEgRGRLTQEDLR 153
Cdd:COG1956   80 GTAAAEGETQLVPDVHafpghiACD----------SASRSEIVVPIFKDGEVIGVLDIDSPT-PGRFDEEDQA 141
GAF pfam01590
GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl ...
 24-166 3.18e-05

GAF domain; This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54. This domain can bind biliverdine and phycocyanobilin (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460259 [Multi-domain]  Cd Length: 133  Bit Score: 42.47  E-value: 3.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827623882   24 SLEKGLAGLAALVSHAMECERCSIMLLKPDpdgGAARLRVQAHHGYLPDHAYDVrqplgsGISGRVASARKGLLIRDLHA 103
Cdd:pfam01590   1 DLEEILQTILEELRELLGADRCALYLPDAD---GLEYLPPGARWLKAAGLEIPP------GTGVTVLRTGRPLVVPDAAG 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 827623882  104 SD-LAAEARRAEGAGPVDVIAVPVILEGDLLGVINIDSPegRGRLTQEDLRRALILALVVAKSV 166
Cdd:pfam01590  72 DPrFLDPLLLLRNFGIRSLLAVPIIDDGELLGVLVLHHP--RPPFTEEELELLEVLADQVAIAL 133
FhlA COG3604
FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis ...
 55-167 6.44e-05

FhlA-type transcriptional regulator, contains GAF, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 442823 [Multi-domain]  Cd Length: 338  Bit Score: 43.30  E-value: 6.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827623882  55 DGGAARLRVQAHHGYLPDHAYDVRQPLGSGISGRVASARKGLLIRDLHASDLAAEARRAEGAGPVDVIAVPVILEGDLLG 134
Cdd:COG3604   10 LPLLLLLALALLLLVLLLLALLLRGDLLASALVLEESLELLALALSEALLAAQARQAALAARERQLFLGVPLRVGGEVLG 89

                         90       100       110
                 ....*....|....*....|....*....|...
gi 827623882 135 VINIDSPEgRGRLTQEDLRRALILALVVAKSVL 167
Cdd:COG3604   90 VLTLDSRR-PGAFSEEDLRLLETLASLAAVAIL 121
GAF_2 pfam13185
GAF domain; The GAF domain is named after some of the proteins it is found in, including ...
 62-163 7.36e-05

GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 433019 [Multi-domain]  Cd Length: 137  Bit Score: 41.68  E-value: 7.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827623882   62 RVQAHHGYLPDHAYDVRQPLGSGISGRVASARKGLLIRDLhASDLAAEARRAEGAGPVDVIAVPVILEGDLLGVINIDSP 141
Cdd:pfam13185  34 RLAAWGGAADELSAALDDPPGEGLVGEALRTGRPVIVNDL-AADPAKKGLPAGHAGLRSFLSVPLVSGGRVVGVLALGSN 112

                          90       100
                  ....*....|....*....|..
gi 827623882  142 EgRGRLTQEDLRRALILALVVA 163
Cdd:pfam13185 113 R-PGAFDEEDLELLELLAEQAA 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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