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Conserved domains on  [gi|82524373|ref|YP_406555|]
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large T antigen [Simian virus 12]

Protein Classification

PHA02624 family protein( domain architecture ID 11476056)

PHA02624 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02624 PHA02624
large T antigen; Provisional
 1-637 0e+00

large T antigen; Provisional


:

Pssm-ID: 222912 [Multi-domain]  Cd Length: 647  Bit Score: 1175.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373    1 MDKVLNREESMELMDLLGLERAAWGNLPLMRKAYLRKCKEFHPDKGGDEDKMKRMNTLYKKMEQDVKVAHQPdFGAWHSS 80
Cdd:PHA02624   1 MDKTLSREESKELMDLLGLPMAAWGNLPLMRKAYLRKCKEYHPDKGGDEEKMKRLNSLYKKLQEGVKSARQS-FGTQDSS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   81 EVPTYGTEEWEAWWSSFNEKWDEDLFCHEDMFQSDEE--------------GTADSQHSTPPKKKRKVEDPKDFPPDLHA 146
Cdd:PHA02624  80 EIPTYGTPEWEQWWEEFNEKWDEDLFCDEELSSSDDEdeppppspppsqeeESQSSSQATPPKKKKKNPAPNDFPSCLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  147 FLSQAVFSNRTLACFAVYTTKEKGQILYKKLMEKYSVTFISRHSSHGHNILFFLTPHRHRVSAINNFCQKLCTFSFLICK 226
Cdd:PHA02624 160 FLSHAIFSNKTLTCFLIYTTKEKAELLYKKLLEKFNPTFISRHSYDGGALLFIITPGKHRVSAVNNFCKKHCTVSFLICK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  227 GVNKEYLLYSTLSRDPYSIVEESIQGGLKEHDFNPEEPEEtKQVSWKLITEYALETKCEDVFLLLGMYLEFQHNPEECRK 306
Cdd:PHA02624 240 GVKKEYELYSALCRDPFKLLEESIPGGLKEYEFNPEEEEE-KQVNWKLITDFALETNCDDVLLLLGLYLEFAVPPEECKK 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  307 CQKKEQPYHFKFHEKHFANATIFADSKNQKSICQQAVDTVLAKKRVDTLHMTREEMLTERFNHILDKMDIMFGatGSAVL 386
Cdd:PHA02624 319 CQKKKLKTHFKYHEKHHENAKLFLDSKNQKTICQQAVDGVLAKRRVKLLTMTREELLAERFKKLLDKMDEIFK--GSVDI 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  387 EHYMAGVAWLHCLLPKMDTLIYDFLNCIVFNIPKRRYWLFKGPIDSGKTTLAAGLLDLCGGKALNVNLPMERLTFELGVA 466
Cdd:PHA02624 397 LQYMAGVAWLHCLLPNFDDVIYDILKLIVENVPKRRYWLFKGPVNSGKTTLAAALLDLCGGKSLNVNCPPDKLNFELGCA 476

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  467 IDQFMVVFEDVKGSGAESKDLPSGHGINNLDSLRDYLDGSVKVNLEKKHLNKRTQIFPPGLVTMNEYPLPKTLQARFVKQ 546
Cdd:PHA02624 477 IDQFMVVFEDVKGQPADNKDLPSGQGMNNLDNLRDYLDGSVPVNLEKKHLNKRSQIFPPGIVTMNEYLIPQTVKARFAKV 556

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  547 IDFKPKIYLRKALNNSEFLLEKRILQSGMTLLLLLIWFRPVADFASDIQHRIVQWKERLDSEISMYTFSRMKYNICMGKC 626
Cdd:PHA02624 557 LDFKPKPYLKKSLKKNEYLLEKRILQSGETLLLLLIWYRPVEDFAEEIQEKVVTWKERLDKEVSDTTFATMKENIHEGKD 636

                        650
                 ....*....|.
gi 82524373  627 ILDWAREEESE 637
Cdd:PHA02624 637 PLEKIVEEDSD 647
 
Name Accession Description Interval E-value
PHA02624 PHA02624
large T antigen; Provisional
 1-637 0e+00

large T antigen; Provisional


Pssm-ID: 222912 [Multi-domain]  Cd Length: 647  Bit Score: 1175.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373    1 MDKVLNREESMELMDLLGLERAAWGNLPLMRKAYLRKCKEFHPDKGGDEDKMKRMNTLYKKMEQDVKVAHQPdFGAWHSS 80
Cdd:PHA02624   1 MDKTLSREESKELMDLLGLPMAAWGNLPLMRKAYLRKCKEYHPDKGGDEEKMKRLNSLYKKLQEGVKSARQS-FGTQDSS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   81 EVPTYGTEEWEAWWSSFNEKWDEDLFCHEDMFQSDEE--------------GTADSQHSTPPKKKRKVEDPKDFPPDLHA 146
Cdd:PHA02624  80 EIPTYGTPEWEQWWEEFNEKWDEDLFCDEELSSSDDEdeppppspppsqeeESQSSSQATPPKKKKKNPAPNDFPSCLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  147 FLSQAVFSNRTLACFAVYTTKEKGQILYKKLMEKYSVTFISRHSSHGHNILFFLTPHRHRVSAINNFCQKLCTFSFLICK 226
Cdd:PHA02624 160 FLSHAIFSNKTLTCFLIYTTKEKAELLYKKLLEKFNPTFISRHSYDGGALLFIITPGKHRVSAVNNFCKKHCTVSFLICK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  227 GVNKEYLLYSTLSRDPYSIVEESIQGGLKEHDFNPEEPEEtKQVSWKLITEYALETKCEDVFLLLGMYLEFQHNPEECRK 306
Cdd:PHA02624 240 GVKKEYELYSALCRDPFKLLEESIPGGLKEYEFNPEEEEE-KQVNWKLITDFALETNCDDVLLLLGLYLEFAVPPEECKK 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  307 CQKKEQPYHFKFHEKHFANATIFADSKNQKSICQQAVDTVLAKKRVDTLHMTREEMLTERFNHILDKMDIMFGatGSAVL 386
Cdd:PHA02624 319 CQKKKLKTHFKYHEKHHENAKLFLDSKNQKTICQQAVDGVLAKRRVKLLTMTREELLAERFKKLLDKMDEIFK--GSVDI 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  387 EHYMAGVAWLHCLLPKMDTLIYDFLNCIVFNIPKRRYWLFKGPIDSGKTTLAAGLLDLCGGKALNVNLPMERLTFELGVA 466
Cdd:PHA02624 397 LQYMAGVAWLHCLLPNFDDVIYDILKLIVENVPKRRYWLFKGPVNSGKTTLAAALLDLCGGKSLNVNCPPDKLNFELGCA 476

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  467 IDQFMVVFEDVKGSGAESKDLPSGHGINNLDSLRDYLDGSVKVNLEKKHLNKRTQIFPPGLVTMNEYPLPKTLQARFVKQ 546
Cdd:PHA02624 477 IDQFMVVFEDVKGQPADNKDLPSGQGMNNLDNLRDYLDGSVPVNLEKKHLNKRSQIFPPGIVTMNEYLIPQTVKARFAKV 556

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  547 IDFKPKIYLRKALNNSEFLLEKRILQSGMTLLLLLIWFRPVADFASDIQHRIVQWKERLDSEISMYTFSRMKYNICMGKC 626
Cdd:PHA02624 557 LDFKPKPYLKKSLKKNEYLLEKRILQSGETLLLLLIWYRPVEDFAEEIQEKVVTWKERLDKEVSDTTFATMKENIHEGKD 636

                        650
                 ....*....|.
gi 82524373  627 ILDWAREEESE 637
Cdd:PHA02624 637 PLEKIVEEDSD 647
Polyoma_lg_T_C pfam06431
Polyomavirus large T antigen C-terminus;
267-693 0e+00

Polyomavirus large T antigen C-terminus;


Pssm-ID: 283968  Cd Length: 417  Bit Score: 859.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   267 TKQVSWKLITEYALETKCEDVFLLLGMYLEFQHNPEECRKCQKKEQPYHFKFHEKHFANATIFADSKNQKSICQQAVDTV 346
Cdd:pfam06431   1 TKQVSWKLVTEYAMETKCEDVFLLLGMYLEFQYNFEMCKKCIKKDQPSHFKYHEKHYANAAIFADSKNQKSICQQAVDTV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   347 LAKKRVDTLHMTREEMLTERFNHILDKMDIMFGATGSAVLEHYMAGVAWLHCLLPKMDTLIYDFLNCIVFNIPKRRYWLF 426
Cdd:pfam06431  81 LAKKRVDSLHMTREEMLTERFNDLLDKMDLIFGAHGNAVLEQYMAGVAWLHCLLPKMDSVIYDFLKCIVYNIPKKRYWLF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   427 KGPIDSGKTTLAAGLLDLCGGKALNVNLPMERLTFELGVAIDQFMVVFEDVKGSGAESKDLPSGHGINNLDSLRDYLDGS 506
Cdd:pfam06431 161 KGPIDSGKTTLAAALLDLCGGKALNVNLPLERLNFELGVAIDQFMVVFEDVKGTGAESRDLPSGHGINNLDNLRDYLDGS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   507 VKVNLEKKHLNKRTQIFPPGLVTMNEYPLPKTLQARFVKQIDFKPKIYLRKALNNSEFLLEKRILQSGMTLLLLLIWFRP 586
Cdd:pfam06431 241 VKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVRQIDFRPKDYLRKSLERSEFLLEKRILQSGMTLLLLLIWFRP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   587 VADFASDIQHRIVQWKERLDSEISMYTFSRMKYNICMGKCILDWAREEESETEDSGHGSSTESQSQCFSQASDTSGsada 666
Cdd:pfam06431 321 VADFAQSIQSRIVEWKERLDKEISMYTFSKMKFNVAMGIGILDWLREEDSEDEDSGHGSSTESQSQCKSQVSHESG---- 396

                         410       420
                  ....*....|....*....|....*..
gi 82524373   667 PASQTpdpydhDNPYHICKGFVCFKRP 693
Cdd:pfam06431 397 IDSQS------QGSFHACKGFQCFEVP 417
DnaJ smart00271
DnaJ molecular chaperone homology domain;
11-67 1.35e-09

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 54.55  E-value: 1.35e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 82524373     11 MELMDLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGGD-----EDKMKRMNTLYKKMEQDVK 67
Cdd:smart00271   1 TDYYEILGVPRDA--SLDEIKKAYRKLALKYHPDKNPGdkeeaEEKFKEINEAYEVLSDPEK 60
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
15-59 2.40e-04

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 40.47  E-value: 2.40e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 82524373  15 DLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGG-----DEDKMKRMNTLY 59
Cdd:COG2214   9 AVLGVPPDA--SLEEIRQAYRRLAKLLHPDRGGelkalAEELFQRLNEAY 56
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 12-60 4.04e-04

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 38.68  E-value: 4.04e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 82524373  12 ELMDLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGGD----EDKMKRMNTLYK 60
Cdd:cd06257   1 DYYDILGVPPDA--SDEEIKKAYRKLALKYHPDKNPDdpeaEEKFKEINEAYE 51
 
Name Accession Description Interval E-value
PHA02624 PHA02624
large T antigen; Provisional
 1-637 0e+00

large T antigen; Provisional


Pssm-ID: 222912 [Multi-domain]  Cd Length: 647  Bit Score: 1175.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373    1 MDKVLNREESMELMDLLGLERAAWGNLPLMRKAYLRKCKEFHPDKGGDEDKMKRMNTLYKKMEQDVKVAHQPdFGAWHSS 80
Cdd:PHA02624   1 MDKTLSREESKELMDLLGLPMAAWGNLPLMRKAYLRKCKEYHPDKGGDEEKMKRLNSLYKKLQEGVKSARQS-FGTQDSS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   81 EVPTYGTEEWEAWWSSFNEKWDEDLFCHEDMFQSDEE--------------GTADSQHSTPPKKKRKVEDPKDFPPDLHA 146
Cdd:PHA02624  80 EIPTYGTPEWEQWWEEFNEKWDEDLFCDEELSSSDDEdeppppspppsqeeESQSSSQATPPKKKKKNPAPNDFPSCLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  147 FLSQAVFSNRTLACFAVYTTKEKGQILYKKLMEKYSVTFISRHSSHGHNILFFLTPHRHRVSAINNFCQKLCTFSFLICK 226
Cdd:PHA02624 160 FLSHAIFSNKTLTCFLIYTTKEKAELLYKKLLEKFNPTFISRHSYDGGALLFIITPGKHRVSAVNNFCKKHCTVSFLICK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  227 GVNKEYLLYSTLSRDPYSIVEESIQGGLKEHDFNPEEPEEtKQVSWKLITEYALETKCEDVFLLLGMYLEFQHNPEECRK 306
Cdd:PHA02624 240 GVKKEYELYSALCRDPFKLLEESIPGGLKEYEFNPEEEEE-KQVNWKLITDFALETNCDDVLLLLGLYLEFAVPPEECKK 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  307 CQKKEQPYHFKFHEKHFANATIFADSKNQKSICQQAVDTVLAKKRVDTLHMTREEMLTERFNHILDKMDIMFGatGSAVL 386
Cdd:PHA02624 319 CQKKKLKTHFKYHEKHHENAKLFLDSKNQKTICQQAVDGVLAKRRVKLLTMTREELLAERFKKLLDKMDEIFK--GSVDI 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  387 EHYMAGVAWLHCLLPKMDTLIYDFLNCIVFNIPKRRYWLFKGPIDSGKTTLAAGLLDLCGGKALNVNLPMERLTFELGVA 466
Cdd:PHA02624 397 LQYMAGVAWLHCLLPNFDDVIYDILKLIVENVPKRRYWLFKGPVNSGKTTLAAALLDLCGGKSLNVNCPPDKLNFELGCA 476

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  467 IDQFMVVFEDVKGSGAESKDLPSGHGINNLDSLRDYLDGSVKVNLEKKHLNKRTQIFPPGLVTMNEYPLPKTLQARFVKQ 546
Cdd:PHA02624 477 IDQFMVVFEDVKGQPADNKDLPSGQGMNNLDNLRDYLDGSVPVNLEKKHLNKRSQIFPPGIVTMNEYLIPQTVKARFAKV 556

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373  547 IDFKPKIYLRKALNNSEFLLEKRILQSGMTLLLLLIWFRPVADFASDIQHRIVQWKERLDSEISMYTFSRMKYNICMGKC 626
Cdd:PHA02624 557 LDFKPKPYLKKSLKKNEYLLEKRILQSGETLLLLLIWYRPVEDFAEEIQEKVVTWKERLDKEVSDTTFATMKENIHEGKD 636

                        650
                 ....*....|.
gi 82524373  627 ILDWAREEESE 637
Cdd:PHA02624 637 PLEKIVEEDSD 647
Polyoma_lg_T_C pfam06431
Polyomavirus large T antigen C-terminus;
267-693 0e+00

Polyomavirus large T antigen C-terminus;


Pssm-ID: 283968  Cd Length: 417  Bit Score: 859.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   267 TKQVSWKLITEYALETKCEDVFLLLGMYLEFQHNPEECRKCQKKEQPYHFKFHEKHFANATIFADSKNQKSICQQAVDTV 346
Cdd:pfam06431   1 TKQVSWKLVTEYAMETKCEDVFLLLGMYLEFQYNFEMCKKCIKKDQPSHFKYHEKHYANAAIFADSKNQKSICQQAVDTV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   347 LAKKRVDTLHMTREEMLTERFNHILDKMDIMFGATGSAVLEHYMAGVAWLHCLLPKMDTLIYDFLNCIVFNIPKRRYWLF 426
Cdd:pfam06431  81 LAKKRVDSLHMTREEMLTERFNDLLDKMDLIFGAHGNAVLEQYMAGVAWLHCLLPKMDSVIYDFLKCIVYNIPKKRYWLF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   427 KGPIDSGKTTLAAGLLDLCGGKALNVNLPMERLTFELGVAIDQFMVVFEDVKGSGAESKDLPSGHGINNLDSLRDYLDGS 506
Cdd:pfam06431 161 KGPIDSGKTTLAAALLDLCGGKALNVNLPLERLNFELGVAIDQFMVVFEDVKGTGAESRDLPSGHGINNLDNLRDYLDGS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   507 VKVNLEKKHLNKRTQIFPPGLVTMNEYPLPKTLQARFVKQIDFKPKIYLRKALNNSEFLLEKRILQSGMTLLLLLIWFRP 586
Cdd:pfam06431 241 VKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVRQIDFRPKDYLRKSLERSEFLLEKRILQSGMTLLLLLIWFRP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   587 VADFASDIQHRIVQWKERLDSEISMYTFSRMKYNICMGKCILDWAREEESETEDSGHGSSTESQSQCFSQASDTSGsada 666
Cdd:pfam06431 321 VADFAQSIQSRIVEWKERLDKEISMYTFSKMKFNVAMGIGILDWLREEDSEDEDSGHGSSTESQSQCKSQVSHESG---- 396

                         410       420
                  ....*....|....*....|....*..
gi 82524373   667 PASQTpdpydhDNPYHICKGFVCFKRP 693
Cdd:pfam06431 397 IDSQS------QGSFHACKGFQCFEVP 417
T_Ag_DNA_bind pfam02217
Origin of replication binding protein; This domain of large T antigen binds to the SV40 origin ...
 138-231 8.75e-51

Origin of replication binding protein; This domain of large T antigen binds to the SV40 origin of DNA replication.


Pssm-ID: 280395  Cd Length: 94  Bit Score: 171.34  E-value: 8.75e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373   138 KDFPPDLHAFLSQAVFSNRTLACFAVYTTKEKGQILYKKLMEKYSVTFISRHSSHGHNILFFLTPHRHRVSAINNFCQKL 217
Cdd:pfam02217   1 IDFPADLEAYLSHAISSNKTPNCFLIYTTKEKLQQLYPKLMEKFSPTFHSLAHWGGGYALFIITPTKHRVSAVKNFCKKH 80

                          90
                  ....*....|....
gi 82524373   218 CTFSFLICKGVNKE 231
Cdd:pfam02217  81 CTVSFLIVKGVKKP 94
PHA03102 PHA03102
Small T antigen; Reviewed
 7-81 9.73e-40

Small T antigen; Reviewed


Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 143.27  E-value: 9.73e-40
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 82524373    7 REESMELMDLLGLERAAWGNLPLMRKAYLRKCKEFHPDKGGDEDKMKRMNTLYKKMEQDVKVAHQPDFGAWHSSE 81
Cdd:PHA03102   1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDLDGEEDSSSE 75
DnaJ smart00271
DnaJ molecular chaperone homology domain;
11-67 1.35e-09

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 54.55  E-value: 1.35e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 82524373     11 MELMDLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGGD-----EDKMKRMNTLYKKMEQDVK 67
Cdd:smart00271   1 TDYYEILGVPRDA--SLDEIKKAYRKLALKYHPDKNPGdkeeaEEKFKEINEAYEVLSDPEK 60
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
15-59 2.40e-04

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 40.47  E-value: 2.40e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 82524373  15 DLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGG-----DEDKMKRMNTLY 59
Cdd:COG2214   9 AVLGVPPDA--SLEEIRQAYRRLAKLLHPDRGGelkalAEELFQRLNEAY 56
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 12-60 4.04e-04

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 38.68  E-value: 4.04e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 82524373  12 ELMDLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGGD----EDKMKRMNTLYK 60
Cdd:cd06257   1 DYYDILGVPPDA--SDEEIKKAYRKLALKYHPDKNPDdpeaEEKFKEINEAYE 51
DjlA COG1076
DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];
11-55 7.80e-04

DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440694 [Multi-domain]  Cd Length: 75  Bit Score: 38.62  E-value: 7.80e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 82524373  11 MELMD---LLGLERAAwgNLPLMRKAYLRKCKEFHPDK--GGDEDKMKRM 55
Cdd:COG1076   1 MQLDDafeLLGLPPDA--DDAELKRAYRKLQREHHPDRlaAGLPEEEQRL 48
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 407-505 3.09e-03

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 38.87  E-value: 3.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82524373 407 IYDFLNCIVF----NIPKRRYWLFKGPIDSGKTTLAAGL-----LDLCGGKALNVNLPMERLTFELGVAIDQFMVVFEDV 477
Cdd:cd19510   5 LKDFIKNEDWyndrGIPYRRGYLLYGPPGTGKSSFIAALageldYDICDLNLSEVVLTDDRLNHLLNTAPKQSIILLEDI 84

                        90       100       110
                ....*....|....*....|....*....|....
gi 82524373 478 KGS------GAESKDLPSGHGINNLDSLRDYLDG 505
Cdd:cd19510  85 DAAfesrehNKKNPSAYGGLSRVTFSGLLNALDG 118
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 15-59 3.42e-03

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 38.53  E-value: 3.42e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 82524373  15 DLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGGD----EDKMKRMNTLY 59
Cdd:COG0484   4 EILGVSRDA--SAEEIKKAYRKLAKKYHPDRNPGdpeaEEKFKEINEAY 50
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 15-59 6.15e-03

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 35.53  E-value: 6.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 82524373    15 DLLGLERAAwgNLPLMRKAYLRKCKEFHPDKG----GDEDKMKRMNTLY 59
Cdd:pfam00226   4 EILGVSPDA--SDEEIKKAYRKLALKYHPDKNpgdpEAEEKFKEINEAY 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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