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Conserved domains on  [gi|810061547|gb|AKE13788|]
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kelch repeat and BTB (POZ) domain containing 4, partial [Pseudomugil novaeguineae]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 1015026)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
5-154 6.45e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 71.34  E-value: 6.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 810061547   5 TAACKHGGDLYVVGG----SIPRRMWKCNMHTMDWERCAPLLRDRLHHTmVSVSTEDAIYSLGGKTLQD---TLSNAVIY 77
Cdd:COG3055   16 AAAALLDGKVYVAGGlsggSASNSFEVYDPATNTWSELAPLPGPPRHHA-AAVAQDGKLYVFGGFTGANpssTPLNDVYV 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 810061547  78 YTVKDNKWTETSQLDTAVSGAAGVNLGGTIYLLGGEENDMdfftkPSRLIQCFDTSSQKCQIKPYMlPFAGCMHAAV 154
Cdd:COG3055   95 YDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-----NVAWVEVYDPATGTWTQLAPL-PTPRDHLAAA 165
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
5-154 6.45e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 71.34  E-value: 6.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 810061547   5 TAACKHGGDLYVVGG----SIPRRMWKCNMHTMDWERCAPLLRDRLHHTmVSVSTEDAIYSLGGKTLQD---TLSNAVIY 77
Cdd:COG3055   16 AAAALLDGKVYVAGGlsggSASNSFEVYDPATNTWSELAPLPGPPRHHA-AAVAQDGKLYVFGGFTGANpssTPLNDVYV 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 810061547  78 YTVKDNKWTETSQLDTAVSGAAGVNLGGTIYLLGGEENDMdfftkPSRLIQCFDTSSQKCQIKPYMlPFAGCMHAAV 154
Cdd:COG3055   95 YDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-----NVAWVEVYDPATGTWTQLAPL-PTPRDHLAAA 165
PHA03098 PHA03098
kelch-like protein; Provisional
 35-112 3.33e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.99  E-value: 3.33e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 810061547  35 WERCAPLLRDRlhHTMVSVSTEDAIYSLGGKTLQDTLSNAVIYYTVKDNKWTETSQLDTAVSGAAGVNLGGTIYLLGG 112
Cdd:PHA03098 370 WREEPPLIFPR--YNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGG 445
Kelch_4 pfam13418
Galactose oxidase, central domain;
45-91 1.79e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 1.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 810061547   45 RLHHTMVSVStEDAIYSLGGKTLQDTLSNAVIYYTVKDNKWTETSQL 91
Cdd:pfam13418   2 RAYHTSTSIP-DDTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSL 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
5-154 6.45e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 71.34  E-value: 6.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 810061547   5 TAACKHGGDLYVVGG----SIPRRMWKCNMHTMDWERCAPLLRDRLHHTmVSVSTEDAIYSLGGKTLQD---TLSNAVIY 77
Cdd:COG3055   16 AAAALLDGKVYVAGGlsggSASNSFEVYDPATNTWSELAPLPGPPRHHA-AAVAQDGKLYVFGGFTGANpssTPLNDVYV 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 810061547  78 YTVKDNKWTETSQLDTAVSGAAGVNLGGTIYLLGGEENDMdfftkPSRLIQCFDTSSQKCQIKPYMlPFAGCMHAAV 154
Cdd:COG3055   95 YDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-----NVAWVEVYDPATGTWTQLAPL-PTPRDHLAAA 165
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
2-112 4.92e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 57.86  E-value: 4.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 810061547   2 HQITAAckHGGDLYVVGG--------SIPRRMWKCNMHTMDWERCAPLLRDRLHHTMVSVSTEdaIYSLGGKTLQDTLSN 73
Cdd:COG3055   63 HAAAVA--QDGKLYVFGGftganpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGK--IYVVGGWDDGGNVAW 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 810061547  74 AVIYyTVKDNKWTETSQLDTAVSGAAGVNL-GGTIYLLGG 112
Cdd:COG3055  139 VEVY-DPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGG 177
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
5-115 1.80e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 56.32  E-value: 1.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 810061547   5 TAACKHGGDLYVVGGsipRRMwkcNMHTMDWERCAPLLRDRLHHTMVSVSteDAIYSLGGKTlqdTLSNAVIYYTVKDNK 84
Cdd:COG3055  163 AAAVLPDGKILVIGG---RNG---SGFSNTWTTLAPLPTARAGHAAAVLG--GKILVFGGES---GFSDEVEAYDPATNT 231

                         90       100       110
                 ....*....|....*....|....*....|.
gi 810061547  85 WTETSQLDTAVSGAAGVNLGGTIYLLGGEEN 115
Cdd:COG3055  232 WTALGELPTPRHGHAAVLTDGKVYVIGGETK 262
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
34-193 6.34e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 48.61  E-value: 6.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 810061547  34 DWERCAPLLRDRLHHTMVSVSteDAIYSLGGKTLQDTlSNAVIYYTVKDNKWTETSQLDT-AVSGAAGVNLGGTIYLLGG 112
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLD--GKVYVAGGLSGGSA-SNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 810061547 113 EENDMDFFTkPSRLIQCFDTSSQKCQIKPYMlPFAGCMHAAVHMDVIFIVAEGDSLVCYNPLLESFTrlRFPEVWSCIPS 192
Cdd:COG3055   79 FTGANPSST-PLNDVYVYDPATNTWTKLAPM-PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYD--PATGTWTQLAP 154


                 .
gi 810061547 193 L 193
Cdd:COG3055  155 L 155
PHA03098 PHA03098
kelch-like protein; Provisional
 35-112 3.33e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.99  E-value: 3.33e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 810061547  35 WERCAPLLRDRlhHTMVSVSTEDAIYSLGGKTLQDTLSNAVIYYTVKDNKWTETSQLDTAVSGAAGVNLGGTIYLLGG 112
Cdd:PHA03098 370 WREEPPLIFPR--YNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGG 445
PHA03098 PHA03098
kelch-like protein; Provisional
 12-160 7.55e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 42.83  E-value: 7.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 810061547  12 GDLYVVGG-----SIPRRMWKCNMHTMDWERCAPLLRDrlHHTMVSVSTEDAIYSLGGKTLQDTLS--NAVIYYTVKDNK 84
Cdd:PHA03098 390 NLIYVIGGiskndELLKTVECFSLNTNKWSKGSPLPIS--HYGGCAIYHDGKIYVIGGISYIDNIKvyNIVESYNPVTNK 467

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 810061547  85 WTETSQLDTAVSGAAGVNLGGTIYLLGGeendmDFFTKPSRLIQCFDTSSQKCQIKPYMLPFAGcmhaAVHMDVIF 160
Cdd:PHA03098 468 WTELSSLNFPRINASLCIFNNKIYVVGG-----DKYEYYINEIEVYDDKTNTWTLFCKFPKVIG----SLEKNIFT 534
Kelch_4 pfam13418
Galactose oxidase, central domain;
45-91 1.79e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 1.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 810061547   45 RLHHTMVSVStEDAIYSLGGKTLQDTLSNAVIYYTVKDNKWTETSQL 91
Cdd:pfam13418   2 RAYHTSTSIP-DDTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSL 47
PHA03098 PHA03098
kelch-like protein; Provisional
 52-116 2.08e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 38.60  E-value: 2.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 810061547  52 SVSTEDAIYSLGGKTLQDTLSNAVIYYTVKDNKWTETSQLDTAVSGAAGVNLGGTIYLLGGEEND 116
Cdd:PHA03098 290 SVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNS 354
PHA02713 PHA02713
hypothetical protein; Provisional
 24-119 2.40e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 38.45  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 810061547  24 RMWKCNMHTMDWERCAPLLRDRLHHTMVSVstEDAIYSLGGKTlQDTLSNAVIYYTVKDNKWTETSQLDTAVSGAAGVNL 103
Cdd:PHA02713 321 KVYKINIENKIHVELPPMIKNRCRFSLAVI--DDTIYAIGGQN-GTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVL 397

                         90
                 ....*....|....*.
gi 810061547 104 GGTIYLLGGEENDMDF 119
Cdd:PHA02713 398 DQYIYIIGGRTEHIDY 413
Kelch_6 pfam13964
Kelch motif;
45-94 5.26e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 33.85  E-value: 5.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 810061547   45 RLHHTMVSVstEDAIYSLGGKTLQDTLSNAVIYYTVKDNKWTETSQLDTA 94
Cdd:pfam13964   2 RTFHSVVSV--GGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTP 49
Kelch_6 pfam13964
Kelch motif;
10-45 8.06e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 33.46  E-value: 8.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 810061547   10 HGGDLYVVGGSIP-----RRMWKCNMHTMDWERCAPLLRDR 45
Cdd:pfam13964  10 VGGYIYVFGGYTNaspalNKLEVYNPLTKSWEELPPLPTPR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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