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Conserved domains on  [gi|808055248|ref|WP_046216666|]
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helix-turn-helix domain-containing protein [Paenibacillus wulumuqiensis]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
2-101 3.34e-44

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 139.23  E-value: 3.34e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055248   2 KQYHMGIEATLEVIGGKWKALIICLLMTGTKRTSELQRNIQGISQKVLIQQLRELERDGLVTRYVYQQMPPKVEYSLTEY 81
Cdd:COG1733    6 KEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEK 85

                         90       100
                 ....*....|....*....|
gi 808055248  82 GVTANRIVEVMCSWGTENIR 101
Cdd:COG1733   86 GRSLLPVLDALAEWGEEHLP 105
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
2-101 3.34e-44

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 139.23  E-value: 3.34e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055248   2 KQYHMGIEATLEVIGGKWKALIICLLMTGTKRTSELQRNIQGISQKVLIQQLRELERDGLVTRYVYQQMPPKVEYSLTEY 81
Cdd:COG1733    6 KEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEK 85

                         90       100
                 ....*....|....*....|
gi 808055248  82 GVTANRIVEVMCSWGTENIR 101
Cdd:COG1733   86 GRSLLPVLDALAEWGEEHLP 105
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 14-100 4.44e-36

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 118.17  E-value: 4.44e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055248   14 VIGGKWKALIICLLMTGTKRTSELQRNIQGISQKVLIQQLRELERDGLVTRYVYQQMPPKVEYSLTEYGVTANRIVEVMC 93
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*..
gi 808055248   94 SWGTENI 100
Cdd:pfam01638  81 DWGEEYL 87
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-92 1.43e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 42.67  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055248  12 LEVIGGKWKALIICLLMTGTKRTSELQRNIqGISQKVLIQQLRELERDGLVTRYvyqQMPPKVEYSLTEYGVTANRIVEV 91
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTDAERLLALLESL 76


                 .
gi 808055248  92 M 92
Cdd:cd00090   77 L 77
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
23-80 1.32e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.49  E-value: 1.32e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 808055248    23 IICLLMTGTKRTSELQRNIqGISQKVLIQQLRELERDGLVTRYVYqqmPPKVEYSLTE 80
Cdd:smart00418   2 ILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVESRRE---GKRVYYSLTD 55
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
2-101 3.34e-44

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 139.23  E-value: 3.34e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055248   2 KQYHMGIEATLEVIGGKWKALIICLLMTGTKRTSELQRNIQGISQKVLIQQLRELERDGLVTRYVYQQMPPKVEYSLTEY 81
Cdd:COG1733    6 KEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEK 85

                         90       100
                 ....*....|....*....|
gi 808055248  82 GVTANRIVEVMCSWGTENIR 101
Cdd:COG1733   86 GRSLLPVLDALAEWGEEHLP 105
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 14-100 4.44e-36

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 118.17  E-value: 4.44e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055248   14 VIGGKWKALIICLLMTGTKRTSELQRNIQGISQKVLIQQLRELERDGLVTRYVYQQMPPKVEYSLTEYGVTANRIVEVMC 93
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*..
gi 808055248   94 SWGTENI 100
Cdd:pfam01638  81 DWGEEYL 87
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-92 1.43e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 42.67  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055248  12 LEVIGGKWKALIICLLMTGTKRTSELQRNIqGISQKVLIQQLRELERDGLVTRYvyqQMPPKVEYSLTEYGVTANRIVEV 91
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTDAERLLALLESL 76


                 .
gi 808055248  92 M 92
Cdd:cd00090   77 L 77
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-67 3.87e-04

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 36.79  E-value: 3.87e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 808055248   6 MGIEATLEVIGGKWKAL-------IICLLMTGTKRTSELQRNIqGISQKVLIQQLRELERDGLVT-----RYVY 67
Cdd:COG0640    1 MSETKELEELAELFKALadptrlrILRLLAEGELCVGELAEAL-GLSQSTVSHHLKVLREAGLVTsrregRWVY 73
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
6-83 1.11e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 35.78  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055248   6 MGIEATLEVIGGKWKALIICLLMTGTKRTSELQRNIqGISQKVLIQQLRELERDGLVTRY--VYQQMPPKVEYSLTEYGV 83
Cdd:COG1777    5 EDLDRLLDALGNPTRRRILALLSEEPAYVSELAREL-GVSRQAVYKHLRKLEEAGLVESYreGREDGRARKYYRLSAFRL 83
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
23-80 1.32e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.49  E-value: 1.32e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 808055248    23 IICLLMTGTKRTSELQRNIqGISQKVLIQQLRELERDGLVTRYVYqqmPPKVEYSLTE 80
Cdd:smart00418   2 ILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVESRRE---GKRVYYSLTD 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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