NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|808055238|ref|WP_046216656|]
View 

magnesium/cobalt transporter CorA [Paenibacillus wulumuqiensis]

Protein Classification

CorA metal ion transporter family protein( domain architecture ID 10191303)

CorA metal ion transporter family protein is involved in transporting divalent cations (uptake or efflux) across membranes, similar to Bacillus subtilis putative metal ion transporter YfjQ

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TmCorA-like_u2 cd12831
Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This ...
 29-319 6.22e-147

Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


:

Pssm-ID: 213365 [Multi-domain]  Cd Length: 287  Bit Score: 414.64  E-value: 6.22e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  29 WCWVDFDRPTEKESELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAVKRDTLNVEEVDLFISENLLVSFHHQK 108
Cdd:cd12831    2 WYWVDFNNPTEEEIKLLTSFFHFHPLAIEDCLHLLQRPKLDYYDDYQFLVLHAIDQEDLEAEEVNLFVGENYIVTFHKEP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 109 QPEVDSAWERVLSYRTgkrpkWMRGPIAAAYIIIDKIVDEYFPCVFDIEDELNELESLGPDEAVDELLAQVFALRSRLLK 188
Cdd:cd12831   82 IREINEVWEKLKEKKD-----KKLGTLYIAYMIIDKIVDDYFPIVYEIEDRLNEIEDNNVDSSNKKLMDEVFDIRSDLLK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 189 LRRTVVPMRDLMYRVVNSQHIQKVDDHHSYFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLTVITTI 268
Cdd:cd12831  157 LRRTILPMRDLLYRILNSERLEGDKEQRAYFQDIYDHLLKLSEMLESNREMTADIRDNYESYNSNRMNSIMMTLTIISTI 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 808055238 269 FMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGWF 319
Cdd:cd12831  237 FMPLTFIAGIYGMNFEYMPELKWHYGYFVVLGIMLLIAIGMILWFKKKGWF 287
 
Name Accession Description Interval E-value
TmCorA-like_u2 cd12831
Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This ...
 29-319 6.22e-147

Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213365 [Multi-domain]  Cd Length: 287  Bit Score: 414.64  E-value: 6.22e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  29 WCWVDFDRPTEKESELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAVKRDTLNVEEVDLFISENLLVSFHHQK 108
Cdd:cd12831    2 WYWVDFNNPTEEEIKLLTSFFHFHPLAIEDCLHLLQRPKLDYYDDYQFLVLHAIDQEDLEAEEVNLFVGENYIVTFHKEP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 109 QPEVDSAWERVLSYRTgkrpkWMRGPIAAAYIIIDKIVDEYFPCVFDIEDELNELESLGPDEAVDELLAQVFALRSRLLK 188
Cdd:cd12831   82 IREINEVWEKLKEKKD-----KKLGTLYIAYMIIDKIVDDYFPIVYEIEDRLNEIEDNNVDSSNKKLMDEVFDIRSDLLK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 189 LRRTVVPMRDLMYRVVNSQHIQKVDDHHSYFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLTVITTI 268
Cdd:cd12831  157 LRRTILPMRDLLYRILNSERLEGDKEQRAYFQDIYDHLLKLSEMLESNREMTADIRDNYESYNSNRMNSIMMTLTIISTI 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 808055238 269 FMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGWF 319
Cdd:cd12831  237 FMPLTFIAGIYGMNFEYMPELKWHYGYFVVLGIMLLIAIGMILWFKKKGWF 287
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
29-319 1.27e-96

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 287.88  E-value: 1.27e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  29 WCWVDFDRPTEKESELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAV----KRDTLNVEEVDLFISENLLVSF 104
Cdd:COG0598   15 FVWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEQRPKLEEYDDYLFIVLRTLnyneEEEELETGPLSIFLGPNFLITV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 105 HHQKQPEVDSAWERVLSyRTGKRPkwmRGPIAAAYIIIDKIVDEYFPCVFDIEDELNELESLGPDEAVDELLAQVFALRS 184
Cdd:COG0598   95 RERPLDAFDDVRERLER-GPGLLP---RGPDYLLYALLDAIVDRYFPVLEELEDELDELEDELFESPDNELLRRLYRLRR 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 185 RLLKLRRTVVPMRDLMYRVVNSQHIQKVDDHHSYFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLTV 264
Cdd:COG0598  171 ELVRLRRALAPLREVLSRLLRGESPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLISNRQNEIMKVLTI 250

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 808055238 265 ITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGWF 319
Cdd:COG0598  251 IAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 9-319 2.68e-84

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 256.93  E-value: 2.68e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238    9 HEHMIVEDVpLEKVKSGDYIWCWVDFDRPTEKES-ELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAVKRD-- 85
Cdd:TIGR00383   8 KSRLIKIPF-FEEFSQELNTVLWIDLIEPTDEERlAKLGQFFAIHPLALEDILNSPQRPKVEEDEDHLFIISFFLNEDed 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238   86 -TLNVEEVDLFISENLLVSFHHQKQPEVDSAWERVlsyRTGKRpKWMRGPIAAAYIIIDKIVDEYFPCVFDIEDELNELE 164
Cdd:TIGR00383  87 dTFETEQVSFILGKNLLFTIHERELPAFDSIRERI---RTSQK-VFEKGADYLLYDIFDAIIDSYFPLLENIEDELEELE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  165 SLGPDEAVDELLAQVFALRSRLLKLRRTVVPMRDLMYRVVNSQHIQKV-DDHHSYFGDIYDHLLKLSDMIEADREMTSDL 243
Cdd:TIGR00383 163 DEIISGPTSTLMDEILSLRTELLALRRSLWPLRDVLNFLLRKTHLPIQtEEVREYLRDIYDHILSLLEMIETYRELLSSL 242

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 808055238  244 RDSYISLNSNRMNTIMKTLTVITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGWF 319
Cdd:TIGR00383 243 MDLYLSLVNNKMNEIMKILTVVSTIFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRRKGWL 318
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 29-320 1.93e-65

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 207.55  E-value: 1.93e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238   29 WCWVDFDRPTEKESELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAVKRDTLNVE----EVDLFISENLLVSF 104
Cdd:pfam01544   4 FVWLDLDSPTEAELEWLARTLGLDPLALEDLLDPEERPRVEDYDDYFLLVLPGVNLDDSEEAdelvTVSILLGDNFLITV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  105 HHQKQPEVDSAWERVLSYRTGKRpkwmrGPIAAAYIIIDKIVDEYFPCVFDIEDELNELESLGPDEAVDELLAQVFALRS 184
Cdd:pfam01544  84 RHEPLPALDEVRKRLTLLGGGPL-----DPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELEDETNNELLRELAALRR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  185 RLLKLRRTVVPMRDLMYRVVNSQHIQKVDDHHS-YFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLT 263
Cdd:pfam01544 159 SLVYLRRSLLPQRDVLNRLLRREDDPLLDDEQKeYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKVLT 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 808055238  264 VITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFqrrgWFK 320
Cdd:pfam01544 239 VVTAIFLPLTLITGIYGMNFGGLPELEWSYGYPFVLILGLMILLAILLLF----YFR 291
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
247-318 1.08e-19

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 87.47  E-value: 1.08e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 808055238 247 YISLNSNRmntIMKTLTVITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGW 318
Cdd:PRK11085 247 FINIEQNR---IIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIILMILAGLAPYLYFKRKNW 315
 
Name Accession Description Interval E-value
TmCorA-like_u2 cd12831
Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This ...
 29-319 6.22e-147

Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213365 [Multi-domain]  Cd Length: 287  Bit Score: 414.64  E-value: 6.22e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  29 WCWVDFDRPTEKESELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAVKRDTLNVEEVDLFISENLLVSFHHQK 108
Cdd:cd12831    2 WYWVDFNNPTEEEIKLLTSFFHFHPLAIEDCLHLLQRPKLDYYDDYQFLVLHAIDQEDLEAEEVNLFVGENYIVTFHKEP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 109 QPEVDSAWERVLSYRTgkrpkWMRGPIAAAYIIIDKIVDEYFPCVFDIEDELNELESLGPDEAVDELLAQVFALRSRLLK 188
Cdd:cd12831   82 IREINEVWEKLKEKKD-----KKLGTLYIAYMIIDKIVDDYFPIVYEIEDRLNEIEDNNVDSSNKKLMDEVFDIRSDLLK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 189 LRRTVVPMRDLMYRVVNSQHIQKVDDHHSYFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLTVITTI 268
Cdd:cd12831  157 LRRTILPMRDLLYRILNSERLEGDKEQRAYFQDIYDHLLKLSEMLESNREMTADIRDNYESYNSNRMNSIMMTLTIISTI 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 808055238 269 FMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGWF 319
Cdd:cd12831  237 FMPLTFIAGIYGMNFEYMPELKWHYGYFVVLGIMLLIAIGMILWFKKKGWF 287
TmCorA-like cd12822
Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential ...
 31-319 1.63e-99

Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the Thermotoga maritima CorA_like family are found in all three kingdoms of life. It is a functionally diverse family, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213356 [Multi-domain]  Cd Length: 289  Bit Score: 294.48  E-value: 1.63e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  31 WVDFDRPTEKESELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAVKRDT----LNVEEVDLFISENLLVSFHH 106
Cdd:cd12822    1 WIDLEGPTEEELQLLAEEFGFHPLAIEDALNERQRPKIEEYDDYLFLVLRALRYDEeeleLETSELSIFLGKNFLVTVHE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 107 QKQPEVDSAWERVLSYRTGKRpkwmRGPIAAAYIIIDKIVDEYFPCVFDIEDELNELESLGPDEAVDELLAQVFALRSRL 186
Cdd:cd12822   81 GPLRLIDEVIERLLSDPKLLP----KGPDFLLYAILDAIVDSYFPILDELEDRLDELEDEILEEPRREVLRELFALRREL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 187 LKLRRTVVPMRDLMYRVVN--SQHIQKVDDHhsYFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLTV 264
Cdd:cd12822  157 LRLRRILSPQREVLNRLLRreNELISEELRP--YFRDVYDHLERLAELLDSYRDLLSSLLDAYLSLQSNRTNEVMKVLTI 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 808055238 265 ITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGWF 319
Cdd:cd12822  235 ITTIFLPLTFITGIYGMNFEYMPELHWPYGYFIVLGIMLLIAGGLLWWFRRKKWL 289
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
29-319 1.27e-96

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 287.88  E-value: 1.27e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  29 WCWVDFDRPTEKESELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAV----KRDTLNVEEVDLFISENLLVSF 104
Cdd:COG0598   15 FVWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEQRPKLEEYDDYLFIVLRTLnyneEEEELETGPLSIFLGPNFLITV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 105 HHQKQPEVDSAWERVLSyRTGKRPkwmRGPIAAAYIIIDKIVDEYFPCVFDIEDELNELESLGPDEAVDELLAQVFALRS 184
Cdd:COG0598   95 RERPLDAFDDVRERLER-GPGLLP---RGPDYLLYALLDAIVDRYFPVLEELEDELDELEDELFESPDNELLRRLYRLRR 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 185 RLLKLRRTVVPMRDLMYRVVNSQHIQKVDDHHSYFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLTV 264
Cdd:COG0598  171 ELVRLRRALAPLREVLSRLLRGESPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLISNRQNEIMKVLTI 250

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 808055238 265 ITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGWF 319
Cdd:COG0598  251 IAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 9-319 2.68e-84

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 256.93  E-value: 2.68e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238    9 HEHMIVEDVpLEKVKSGDYIWCWVDFDRPTEKES-ELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAVKRD-- 85
Cdd:TIGR00383   8 KSRLIKIPF-FEEFSQELNTVLWIDLIEPTDEERlAKLGQFFAIHPLALEDILNSPQRPKVEEDEDHLFIISFFLNEDed 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238   86 -TLNVEEVDLFISENLLVSFHHQKQPEVDSAWERVlsyRTGKRpKWMRGPIAAAYIIIDKIVDEYFPCVFDIEDELNELE 164
Cdd:TIGR00383  87 dTFETEQVSFILGKNLLFTIHERELPAFDSIRERI---RTSQK-VFEKGADYLLYDIFDAIIDSYFPLLENIEDELEELE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  165 SLGPDEAVDELLAQVFALRSRLLKLRRTVVPMRDLMYRVVNSQHIQKV-DDHHSYFGDIYDHLLKLSDMIEADREMTSDL 243
Cdd:TIGR00383 163 DEIISGPTSTLMDEILSLRTELLALRRSLWPLRDVLNFLLRKTHLPIQtEEVREYLRDIYDHILSLLEMIETYRELLSSL 242

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 808055238  244 RDSYISLNSNRMNTIMKTLTVITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGWF 319
Cdd:TIGR00383 243 MDLYLSLVNNKMNEIMKILTVVSTIFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRRKGWL 318
TmCorA-like_1 cd12828
Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima ...
 30-319 3.67e-84

Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213362 [Multi-domain]  Cd Length: 294  Bit Score: 255.43  E-value: 3.67e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  30 CWVDFDRPTEKES-ELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAV----KRDTLNVEEVDLFISENLLVSF 104
Cdd:cd12828    3 TWINVDGLHDIELiEKLGERFGLHPLVLEDILNTGQRPKVEEYDDYLFIVLKMLyydeDTGELESEQVSLILGKNYVISF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 105 HHQKQPEVDSAWERVlsyRTGKRPKWMRGPIAAAYIIIDKIVDEYFPCVFDIEDELNELESLGPDEAVDELLAQVFALRS 184
Cdd:cd12828   83 QERPGDVFDPVRERL---RNGKGRIRKKGADYLAYALLDAIVDNYFPVLEKLGDRIEDLEEELLENPTPETLERIHKLKR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 185 RLLKLRRTVVPMRDLMYRVVNSQHIQKVDDHHSYFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLTV 264
Cdd:cd12828  160 ELLFLRRSIWPLREVINRLLRGESPLISEETRPYLRDVYDHTIQVIDTIETYRDMLSGLLDLYLSSVSNRMNEVMKVLTI 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 808055238 265 ITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGWF 319
Cdd:cd12828  240 ISTIFIPLTFIAGIYGMNFEYMPELEWKYGYPAVLGVMLLIALGMLLYFKRKKWL 294
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 29-320 1.93e-65

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 207.55  E-value: 1.93e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238   29 WCWVDFDRPTEKESELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAVKRDTLNVE----EVDLFISENLLVSF 104
Cdd:pfam01544   4 FVWLDLDSPTEAELEWLARTLGLDPLALEDLLDPEERPRVEDYDDYFLLVLPGVNLDDSEEAdelvTVSILLGDNFLITV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  105 HHQKQPEVDSAWERVLSYRTGKRpkwmrGPIAAAYIIIDKIVDEYFPCVFDIEDELNELESLGPDEAVDELLAQVFALRS 184
Cdd:pfam01544  84 RHEPLPALDEVRKRLTLLGGGPL-----DPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELEDETNNELLRELAALRR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  185 RLLKLRRTVVPMRDLMYRVVNSQHIQKVDDHHS-YFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLT 263
Cdd:pfam01544 159 SLVYLRRSLLPQRDVLNRLLRREDDPLLDDEQKeYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKVLT 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 808055238  264 VITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFqrrgWFK 320
Cdd:pfam01544 239 VVTAIFLPLTLITGIYGMNFGGLPELEWSYGYPFVLILGLMILLAILLLF----YFR 291
MtCorA-like cd12830
Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the ...
 30-319 3.57e-64

Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213364 [Multi-domain]  Cd Length: 292  Bit Score: 204.29  E-value: 3.57e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  30 CWVDFDRPTEKESELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAV----KRDTLNVEEVDLFISENLLVSFH 105
Cdd:cd12830    3 VWVGLHEPDAEELAAVAEEFGLHELAVEDAVHAHQRPKLERYGDSLFLVLRTAryvdHTEEVETGETHVFVGPDFVVTVR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 106 HQKQPEVDSAWERVLSyrtgkRPKWMR-GPIAAAYIIIDKIVDEYFPCVFDIEDELNELES--LGPDEAVDelLAQVFAL 182
Cdd:cd12830   83 HGAAGPLARVRARLEA-----DPELLAlGPDAVLYAILDFIVDGYLPVAEELEDDVDELEEevFSPDRRDD--IERIYRL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 183 RSRLLKLRRTVVPMRDLMYRVVNsQHIQKVDDH-HSYFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKT 261
Cdd:cd12830  156 KREVLEFRRAVDPLVEVLRRLAR-GHEPLIPKElRPYFRDVADHLLRVADRVDSLRELLSSALQANLALVSVQQNEDMRK 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 808055238 262 LTVITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGWF 319
Cdd:cd12830  235 ISAWAAILAVPTAIAGIYGMNFDHMPELHWTYGYPLVLGLMVAVCLGLYRRFRRNGWL 292
TmCorA-like_u3 cd12832
Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs ...
 31-318 1.01e-44

Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213366 [Multi-domain]  Cd Length: 287  Bit Score: 153.91  E-value: 1.01e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  31 WVDFDRPTEKESELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHA---VKRDTLN--VEEVD---LFISENLLV 102
Cdd:cd12832    1 WIDVVAPTEEDLEDLARRYNLHETSLKDCLDPDHLPKYEEVDGVTFIILRVytdKKRENADtiQELTTkiaIFVVDKFVI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 103 SFHHQKQPEVDSAWERVLSyrtgkRPKWMRGPIAAAYIIIDKIVDEYfpcvfdiedelnELESLGPDEAVDELLAQVFAL 182
Cdd:cd12832   81 TIHRTDLEFIANLKEKWLS-----GMHKCESPTELLLRIVKDALKTY------------EAPLEKLSEELDKYEEEVFLK 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 183 RSrllklrrTVVPMRDLMY--RVVNSQH---------IQKVDDH---HSYFGDIYDHLLKLSDMIEADREMTSDLRDSYI 248
Cdd:cd12832  144 KR-------KGSLLKRLYHlkRKASVIKrvlnltqdvIDKIDTPlksDPYTQDLRDLLIKLLSLYDELHENATNLLSLYI 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 249 SLNSNRMNTIMKTLTVITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGW 318
Cdd:cd12832  217 SLSSQRTNEVMRVLTIFSVFFLPLTFIAGVYGMNFKYMPELHWKYGYPATLLVMIVIVVGIYFWFKRKGW 286
MIT_CorA-like cd11744
metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of ...
 31-318 6.49e-38

metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. They are found in most bacteria and archaea, and in some eukaryotes. It is a functionally diverse group which includes the Mg2+ transporters of Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and the Zn2+ transporter Salmonella typhimurium ZntB, which mediates the efflux of Zn2+ (and Cd2+). It includes five Saccharomyces cerevisiae members: i) two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, ii) two mitochondrial inner membrane Mg2+ transporters: Mfm1p/Lpe10p, and Mrs2p, and iii) and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. It also includes a family of Arabidopsis thaliana members (AtMGTs), some of which are localized to distinct tissues, and not all of which can transport Mg2+. Thermotoga maritima CorA and Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, Mrs2p, and Alr1p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213354 [Multi-domain]  Cd Length: 286  Bit Score: 136.18  E-value: 6.49e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  31 WVDFDRPTEKESELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAVKRDT----LNVEEVDLFISENLLVSFHH 106
Cdd:cd11744    1 WIHCERLHDDDIRRVLEDNLHVPRALEDILLAESRPSFHPLDDNFMIILRGFNMDEnaspEDMLSVRILYFQGALISTRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 107 QKQPEVDSAWERVLSYRTGKRpkwmrgpiAAAYI---IIDKIVDEYFPCVFDIEDELNELESLGPDEAVDELLAQVFALR 183
Cdd:cd11744   81 IPSRAFMEIRQRLREHSKGPK--------SAASLlnqLIEGLNGKIDLYLETIEETLNELDVNDEEGHYDESTYNHIALQ 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 184 SRLLKLRRTVVPMRDLMYRVVNSQHIQKVDDHHsYFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLT 263
Cdd:cd11744  153 KALISIRRFIRPQQYALRDLIRSESELVTSRPH-QYRFAHNNITRINETIEFYLGEVALLQDEIKHNRDEKTNKNSKLFT 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 808055238 264 VITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGW 318
Cdd:cd11744  232 LVATIFLPTTFLAGLYGMNFEGMPGVESSMAFTWFCIALIVAFGLEWLLFKRKGF 286
EcCorA_ZntB-like cd12821
Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily ...
 31-318 8.98e-37

Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213355 [Multi-domain]  Cd Length: 285  Bit Score: 133.21  E-value: 8.98e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  31 WVDFDRPTEKESELLSTFFEFH-PLAVEDCMHLLQRPKMDYYTDVEFLVLHAVKRDTLNVEEVDLFISENLLVSFHhQKQ 109
Cdd:cd12821    1 WYDIDEPDDEIRRLLEELESSHlPNDLRDILLGVSFPRFEEVSGSGIYIQLRKPQKDADTASFHFLITRDRLITVR-LDE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 110 PEVDSAWERvlsYRTGKRPKWMRGPIAAAYIIIDKIVDEYFPCVFDIEDELNELESLGPDEAVDELLAQVFALRSRLLKL 189
Cdd:cd12821   80 LPALDELRQ---DLRSGQMKSAKSAAELLFVLLGAIIKALLTGIDQFEEKLEELEWDLLEGNNAIKLDRILELRRELLRL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 190 RRTVVPMRDLMYRVVNSQHIQKVDDHHSYFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLTVITTIF 269
Cdd:cd12821  157 TNLIEPQQEVLMALQEAFAELLFSEDEEELRRTLDRIERLLQLIEEYEQELDTLQDIEEVVSSHRGNEIMKTLTVVTTVF 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 808055238 270 MPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGW 318
Cdd:cd12821  237 LPLTLIGGLWGMNFKNMPELEWKYGYLFVLGLIILSTAGLYLYLRRKGW 285
EcCorA_ZntB-like_u1 cd12826
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 218-319 7.32e-31

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA-ZntB_like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB_like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213360  Cd Length: 281  Bit Score: 117.28  E-value: 7.32e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 218 YFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLTVITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFG 297
Cdd:cd12826  180 LFRLFSDRVERLHDNVQMLREYSLQIRELYQSQIDIRQNRIMKILTVVTTIFLPLTLITGWYGMNFTNMPELHWKYGYPV 259

                         90       100
                 ....*....|....*....|..
gi 808055238 298 VLLLMFLLGGCMMLLFQRRGWF 319
Cdd:cd12826  260 VIILSILIVVIEIIYFKKKKWL 281
Alr1p-like cd12829
Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the ...
 31-315 6.94e-30

Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213363 [Multi-domain]  Cd Length: 305  Bit Score: 115.44  E-value: 6.94e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  31 WVDFDRPTEKESELLSTFFEFHPLAVEDCMHLLQRPKMDYYTDVEFLVLHAVKRDTLNVEEVD------LFISENLLVSF 104
Cdd:cd12829    1 WLDVQSPTDDDMRAIGKLFPIHPLTLEDILSQDTREKVELFPNYYFISFRAIESDSELDENVLepvnvyIVVFREGILTF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 105 HHQKQPEVDSAWER--VLSYRTGKRPKWMrgpiaaAYIIIDKIVDEYFPCVFDIEDE---LNELESLGPDEAVDELLAQV 179
Cdd:cd12829   81 HFKPLDHIERVRKRirLLSDSHLLSSDWV------LYALLDSIVDSFFPLVDSIEKEvdsIDELVLLISSSDQSDLLRRI 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 180 FALRSRLLKLRRTVVP----MRDLMYRVVNSQHIQKVDDHHSYFGDIYDHLLKLSDMIEADREMTSDLRDSYISL----- 250
Cdd:cd12829  155 GDLRRRVTSLLRLLFAksdvLKQLLKRLMKKTFVSPDSEVAIYLGDVQDHILTLLQKLNHYEDLLSRSHSNYLAQlslem 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808055238 251 --NSNRMNTIMKTLTVITTIFMPLTLIAGIYGMN----FEFMPELHWKYGYFGVlLLMFLLGGCMMLLFQR 315
Cdd:cd12829  235 sqESNGTDKAMLRLTVIATIFLPLQLITGLFGMNvkvpGQDIESLYWFFGIVIV-AIMVLVAIVVVFLVRR 304
EcCorA-like cd12825
Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the ...
 222-319 1.25e-25

Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB_like(EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporters Escherichia coli, Salmonella typhimurium, and Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213359 [Multi-domain]  Cd Length: 287  Bit Score: 103.55  E-value: 1.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 222 IYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLTVITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLL 301
Cdd:cd12825  190 ELRDLSSLLDHTTFNFDKLDDLKNNILGKIELEQNKIIKIFTVVTVCFLPPTLIASIYGMNFKNMPELKWSYGYPFALIL 269

                         90
                 ....*....|....*...
gi 808055238 302 MFLLGGCMMLLFQRRGWF 319
Cdd:cd12825  270 MILSTILPLLYFKRKGWL 287
EcCorA-like_u1 cd12837
uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A ...
 256-319 2.74e-25

uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A uncharacterized subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA_ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA_ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213371 [Multi-domain]  Cd Length: 298  Bit Score: 102.61  E-value: 2.74e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 808055238 256 NTIMKTLTVITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGWF 319
Cdd:cd12837  235 NNIIKIFSVASVVFLPPTLIASIYGMNFKHMPELDWPFGYPLALGLMVLSAVLPLLWFKRRGWL 298
HpCorA-like cd12836
Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the ...
 243-318 1.31e-23

Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporter Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+); CorA plays an important role in the viability of this pathogen. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB (members of the EcCorA_ZntB-like family) form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213370 [Multi-domain]  Cd Length: 288  Bit Score: 98.10  E-value: 1.31e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 808055238 243 LRDSYISLNSNRMNTIMKTLTVITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGW 318
Cdd:cd12836  212 LQNTFLGLINIEQNKIIKIFTVATVIFMPPTLIASIYGMNFKFMPELDWKYGYPFALLLMVISSILPLLYFKKKKW 287
EcCorA-like_1 cd12835
Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia ...
 247-318 2.44e-22

Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporters Escherichia coli CorA and Salmonella typhimurium CorA (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213369  Cd Length: 287  Bit Score: 94.63  E-value: 2.44e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 808055238 247 YISLNSNRmntIMKTLTVITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGW 318
Cdd:cd12835  218 FINIEQNK---IIKIFSVAAVVFLPPTLIASIYGMNFDFMPELDWKFGYPMAIGLMILSAIAPYLYFKRKGW 286
ZntB-like_1 cd12833
Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to ...
 29-319 3.34e-22

Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213367 [Multi-domain]  Cd Length: 290  Bit Score: 94.10  E-value: 3.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  29 WCWVDFDRPTEKESELLSTFFEFHPLAVEdcmHLLQ---RPKMDYYTDVEFLVLHAVkrdtlNVEE---------VDLFI 96
Cdd:cd12833    2 FLWLHLDYSDPEAQDWLEQSSGLPELVID---ALLAeetRPRATRLGDGLLLNLRGV-----NLNPgadpedmvsIRLWI 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  97 SENLLVSFHHQKqpeVDSAWERVLSYRTGKRPKWMRGPIAAayiIIDKIVDEYFPCVFDIEDELNELESLGPDEAVDELL 176
Cdd:cd12833   74 TPGRIISTRRRR---LLAVDDIREALEAGKGPKSPGDFLAA---LAERLTDRMEDVIDELEDRLDELEERVLEEEDEELR 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 177 AQVFALRSRLLKLRRTVVPMRDLMYRVVNSQHIQKVDDHHSYFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMN 256
Cdd:cd12833  148 GELAELRRQAIALRRYLAPQRDALERLAREDLPWLSDDDRLRLREAADRLTRYIEDLDAIRERAAVLQEELTNRRAEQMN 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 808055238 257 TIMKTLTVITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGWF 319
Cdd:cd12833  228 RRMYVLSIVAAIFLPLGFLTGLLGINVGGIPGAENPWAFWIFCGLLVVLAVGLLLLFRRKKWL 290
EcCorA_ZntB-like_u2 cd12827
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 229-319 4.37e-21

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213361 [Multi-domain]  Cd Length: 289  Bit Score: 91.03  E-value: 4.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 229 LSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLTVITTIFMPLTLIAGIYGMNfEFMPELHWKYGYFGVLLLMFLLGGC 308
Cdd:cd12827  200 AIEMAEIYSDILSGLMDAFASVISNNLNNVMKFLTSITIVLTIPTIITGFYGMN-VPLPFADSPYAFWIILLISLLLSVI 278

                         90
                 ....*....|.
gi 808055238 309 MMLLFQRRGWF 319
Cdd:cd12827  279 VALILRRKKYF 289
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
247-318 1.08e-19

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 87.47  E-value: 1.08e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 808055238 247 YISLNSNRmntIMKTLTVITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGW 318
Cdd:PRK11085 247 FINIEQNR---IIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIILMILAGLAPYLYFKRKNW 315
ZntB_u1 cd12834
Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like ...
 78-317 1.99e-09

Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; The MIT superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. The ZntB-like subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213368 [Multi-domain]  Cd Length: 290  Bit Score: 57.60  E-value: 1.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238  78 VLHAVKRD----TLNVEEVDLFISENLLVSFHHQKQPEVDSAWERVLSyrtGKRPkwmRGPIAAAYIIIDKIVDEYFPCV 153
Cdd:cd12834   51 VLNDLERDfaeaSTDVGTLRFAVTPRLLITARRQPLRSVDRLRQAVER---GLRF---RSPADLLEHLLREQADTLSRIV 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 154 FDIEDELNELESLGPDEAVDELLAQVFALRSRLLKLRRTVVPMRDLMYRVVNSQHIQKVDDHHSYFGDIYDHLLKLSDMI 233
Cdd:cd12834  125 RELTDELDRIEDRLLSGRLRRERRELGALRRRLVRLHRLLAPEPAALFRLLRRPPDWLPDADLETLRRLTERLDALDRDL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 234 EADREMTSDLRDSYISLNSNRMNTIMKTLTVITTIFMPLTLIAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLF 313
Cdd:cd12834  205 VALQERARLLQEEIAARLAEQTNRSLYILSVVTALLLPPTLVTGLFGMNTGGLPLAEGPHGFWIAVALALLAAGLAYLLL 284


                 ....
gi 808055238 314 QRRG 317
Cdd:cd12834  285 RRLG 288
ZntB-like cd12824
Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging ...
 213-317 1.45e-07

Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213358 [Multi-domain]  Cd Length: 290  Bit Score: 52.14  E-value: 1.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 213 DDHHSYfGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLTVITTIFMPLTLIAGIYGMNFEFMPELHWK 292
Cdd:cd12824  185 SDRETL-RRASNNVTRYLETLDFCRTRVALLQDEIKAQRDEKTTRSSLLLTVVATVFLPLTFITGLLGMNVGGIPDVESP 263

                         90       100
                 ....*....|....*....|....*...
gi 808055238 293 YGYF---GVLLLMFLLGGcmmLLFQRRG 317
Cdd:cd12824  264 MGFWwvtGLSILVALLAW---LLLRRLG 288
zntB PRK09546
zinc transporter ZntB;
195-318 9.41e-07

zinc transporter ZntB;


Pssm-ID: 181941  Cd Length: 324  Bit Score: 49.62  E-value: 9.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 195 PMRDLMYRVVNSQHIQKVDDHHSYFGDIYDHLLKLSDMIEADREMTSDLRDSYISLNSNRMNTIMKTLTVITTIFMPLTL 274
Cdd:PRK09546 200 PQRDVFARLASERLPWMSDDDRRRMQDIADRLGRGLDDLDACIARTAVLADEIASVMAEAMNRRTYTMSLMAMVFLPTTF 279

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 808055238 275 IAGIYGMNFEFMPELHWKYGYFGVLLLMFLLGGCMMLLFQRRGW 318
Cdd:PRK09546 280 LTGLFGVNLGGIPGGGWPFGFSIFCLLLVVLIGGVAWWLKRSKW 323
Mrs2_Mfm1p-like cd12823
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like ...
 237-317 1.71e-04

Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; A eukaryotic subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This functionally diverse subfamily includes the inner mitochondrial membrane Mg2+ transporters Saccharomyces cerevisiae Mfm1p/Lpe10p, Mrs2p, and human MRS2/ MRS2L. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of two EcCorA_ZntB-like family transporters: Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213357  Cd Length: 323  Bit Score: 42.62  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808055238 237 REMTSDLRD--SYISLN--SNRmNTIMK---TLTVITTIFMPLTLIAGIYGMNFEFMPElHWKYGYFGVLLLMFLLGG-- 307
Cdd:cd12823  233 EELREYIDDteELINLIldSRR-NQLMRlelKLSIGTLSLAVGTLVAGLFGMNLPSGLE-ESPYAFWIVTGGSVVGSIli 310

                         90
                 ....*....|.
gi 808055238 308 -CMMLLFQRRG 317
Cdd:cd12823  311 fIVVLRYLRRK 321
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH