|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
52-497 |
0e+00 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 698.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 52 DLPPFEKNFYVESPSIAAMTEGEVEEYRRRREITI-EGRDVPKPIKSFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMA 130
Cdd:PTZ00110 85 NLVPFEKNFYKEHPEVSALSSKEVDEIRKEKEITIiAGENVPKPVVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIA 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 131 LKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPILDHGDGPIVLVLAPTRELAVQIQQEATKFGASSRIKNTCIYGGVPKG 210
Cdd:PTZ00110 165 LSGRDMIGIAETGSGKTLAFLLPAIVHINAQPLLRYGDGPIVLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKR 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 211 PQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQ 290
Cdd:PTZ00110 245 GQIYALRRGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQS 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 291 LARQFLFN-AYKVIIGSADLKANHAIRQHVEIVSESQKYNKLVKLLEDIM-DGSRILIFMDTKKGCDQVTRQLRMDGWPA 368
Cdd:PTZ00110 325 LARDLCKEePVHVNVGSLDLTACHNIKQEVFVVEEHEKRGKLKMLLQRIMrDGDKILIFVETKKGADFLTKELRLDGWPA 404
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 369 LSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFVINYDFPGSLEDYVHRIGRTGRAGASGTAYTFFTAA 448
Cdd:PTZ00110 405 LCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPD 484
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 807045801 449 NARFAKDLVNILEEAGQKVSPELAKMGRGAPPPPGHGGFRDRGRGYGGN 497
Cdd:PTZ00110 485 KYRLARDLVKVLREAKQPVPPELEKLSNERSNGTERRRWGGYGRFSNNV 533
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
95-470 |
6.60e-167 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 478.10 E-value: 6.60e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 95 IKSFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAqpilDHGDGPIVLV 174
Cdd:COG0513 1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDP----SRPRAPQALI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 175 LAPTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADR 254
Cdd:COG0513 77 LAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 255 MLDMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKVIIGSADLKANhAIRQHVEIVSESQKYNKLVKL 334
Cdd:COG0513 157 MLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAE-TIEQRYYLVDKRDKLELLRRL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 335 LEDImDGSRILIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFVI 414
Cdd:COG0513 236 LRDE-DPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVI 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 807045801 415 NYDFPGSLEDYVHRIGRTGRAGASGTAYTFFTAANARFAKDlvnILEEAGQKVSPE 470
Cdd:COG0513 315 NYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRA---IEKLIGQKIEEE 367
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
107-302 |
8.11e-144 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 410.61 E-value: 8.11e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPILDHGDGPIVLVLAPTRELAVQIQ 186
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLERGDGPIVLVLAPTRELAQQIQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 187 QEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIRK 266
Cdd:cd17966 81 QEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQIRK 160
|
170 180 190
....*....|....*....|....*....|....*.
gi 807045801 267 IVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKV 302
Cdd:cd17966 161 IVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
46-305 |
1.17e-134 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 390.14 E-value: 1.17e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 46 RKVNLDDLPPFEKNFYVESPSIAAMTEGEVEEYRRRREITIEGRDVPKPIKSFHDVGFPDYVLQEIEKAGFTEPTPIQAQ 125
Cdd:cd18050 12 KKWDLSELPKFEKNFYVEHPEVARMTQYDVEELRRKKEITIRGVGCPKPVFAFHQANFPQYVMDVLLDQNFKEPTPIQCQ 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 126 GWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPILDHGDGPIVLVLAPTRELAVQIQQEATKFGASSRIKNTCIYG 205
Cdd:cd18050 92 GFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQQVADDYGKSSRLKSTCIYG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 206 GVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLYWSATWP 285
Cdd:cd18050 172 GAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWP 251
|
250 260
....*....|....*....|
gi 807045801 286 KEVEQLARQFLFNAYKVIIG 305
Cdd:cd18050 252 KEVRQLAEDFLRDYVQINIG 271
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
84-306 |
9.19e-131 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 378.97 E-value: 9.19e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 84 ITIEGRDVPKPIKSFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPI 163
Cdd:cd18049 12 ITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 164 LDHGDGPIVLVLAPTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRR 243
Cdd:cd18049 92 LERGDGPICLVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRR 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 807045801 244 VTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKVIIGS 306
Cdd:cd18049 172 CTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGA 234
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
96-470 |
1.52e-112 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 340.63 E-value: 1.52e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 96 KSFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPIldhgdGPIVLVL 175
Cdd:PRK11776 4 TAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRF-----RVQALVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 176 APTRELAVQIQQEATKFG-ASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADR 254
Cdd:PRK11776 79 CPTRELADQVAKEIRRLArFIPNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 255 MLDMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKVIIGSADlkANHAIRQHVEIVSESQKYNKLVKL 334
Cdd:PRK11776 159 MLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVESTH--DLPAIEQRFYEVSPDERLPALQRL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 335 LEDIMDGSrILIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFVI 414
Cdd:PRK11776 237 LLHHQPES-CVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVI 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 807045801 415 NYDFPGSLEDYVHRIGRTGRAGASGTAYTFFTAANARfakdLVNILEEA-GQKVSPE 470
Cdd:PRK11776 316 NYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQ----RANAIEDYlGRKLNWE 368
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
107-302 |
2.16e-105 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 312.45 E-value: 2.16e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPIlDHGDGPIVLVLAPTRELAVQIQ 186
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPK-KKGRGPQALVLAPTRELAMQIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 187 QEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIRK 266
Cdd:cd00268 80 EVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDVEK 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 807045801 267 IVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKV 302
Cdd:cd00268 160 ILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
85-303 |
4.29e-104 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 310.46 E-value: 4.29e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 85 TIEGRDVPKPIKSFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPIL 164
Cdd:cd17953 1 KVRGKDCPKPIQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 165 DHGDGPIVLVLAPTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNH---TNL 241
Cdd:cd17953 81 KPGEGPIGLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANNgrvTNL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 807045801 242 RRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKVI 303
Cdd:cd17953 161 RRVTYVVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEIT 222
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
107-302 |
1.10e-95 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 287.77 E-value: 1.10e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPILDHGDGPIVLVLAPTRELAVQIQ 186
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRELEKGEGPIAVIVAPTRELAQQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 187 QEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIRK 266
Cdd:cd17952 81 LEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQVRS 160
|
170 180 190
....*....|....*....|....*....|....*.
gi 807045801 267 IVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKV 302
Cdd:cd17952 161 IVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
97-441 |
5.77e-94 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 292.87 E-value: 5.77e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 97 SFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPILDHGDGPI-VLVL 175
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRPVrALIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 176 APTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRM 255
Cdd:PRK10590 82 TPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 256 LDMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKVIIGSADlKANHAIRQHVEIVSESQKYNKLVKLl 335
Cdd:PRK10590 162 LDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRN-TASEQVTQHVHFVDKKRKRELLSQM- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 336 edIMDGS--RILIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFV 413
Cdd:PRK10590 240 --IGKGNwqQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHV 317
|
330 340
....*....|....*....|....*...
gi 807045801 414 INYDFPGSLEDYVHRIGRTGRAGASGTA 441
Cdd:PRK10590 318 VNYELPNVPEDYVHRIGRTGRAAATGEA 345
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
53-472 |
2.69e-91 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 287.84 E-value: 2.69e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 53 LPPFEKNFYVESPSI-AAMTEGEVEEYRRRREITIEGRDVPKPIKSFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMAL 131
Cdd:PLN00206 77 LPATDECFYVRDPGStSGLSSSQAELLRRKLEIHVKGEAVPPPILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAAL 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 132 KGRDLIGIAETGSGKTIAYLLPAIVHVnAQPILDHGD---GPIVLVLAPTRELAVQIQQEATKFGASSRIKNTCIYGGVP 208
Cdd:PLN00206 157 SGRSLLVSADTGSGKTASFLVPIISRC-CTIRSGHPSeqrNPLAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDA 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 209 KGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIRKIVsQIRPDRQTLYWSATWPKEV 288
Cdd:PLN00206 236 MPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDCMLERGFRDQVMQIF-QALSQPQVLLFSATVSPEV 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 289 EQLARQFLFNAYKVIIGSADlKANHAIRQHVEIVSESQKYNKLVklleDIMDGSR-----ILIFMDTKKGCDQVTRQLRM 363
Cdd:PLN00206 315 EKFASSLAKDIILISIGNPN-RPNKAVKQLAIWVETKQKKQKLF----DILKSKQhfkppAVVFVSSRLGADLLANAITV 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 364 -DGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFVINYDFPGSLEDYVHRIGRTGRAGASGTAY 442
Cdd:PLN00206 390 vTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAI 469
|
410 420 430
....*....|....*....|....*....|
gi 807045801 443 TFFTAANARFAKDLVNILEEAGQKVSPELA 472
Cdd:PLN00206 470 VFVNEEDRNLFPELVALLKSSGAAIPRELA 499
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
96-470 |
6.51e-87 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 277.99 E-value: 6.51e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 96 KSFHDVGFPDYVLQE-----IEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPIL--DHGD 168
Cdd:PRK04537 4 KPLTDLTFSSFDLHPallagLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALadRKPE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 169 GPIVLVLAPTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHT-NLRRVTYL 247
Cdd:PRK04537 84 DPRALILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVvSLHACEIC 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 248 VLDEADRMLDMGFEPQIRKIVSQI--RPDRQTLYWSATWPKEVEQLARQFLFNAYKVIIGSADLKANHaIRQHVEIVSES 325
Cdd:PRK04537 164 VLDEADRMFDLGFIKDIRFLLRRMpeRGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAAR-VRQRIYFPADE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 326 QKYNKLVKLLEDiMDGSRILIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGL 405
Cdd:PRK04537 243 EKQTLLLGLLSR-SEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGL 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 807045801 406 DVKDVKFVINYDFPGSLEDYVHRIGRTGRAGASGTAYTFftaANARFAKDLVNILEEAGQKVSPE 470
Cdd:PRK04537 322 HIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISF---ACERYAMSLPDIEAYIEQKIPVE 383
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
108-447 |
2.30e-86 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 272.20 E-value: 2.30e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 108 LQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHvnaqpILD----HGDGPIVLVLAPTRELAV 183
Cdd:PRK11192 13 LEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQH-----LLDfprrKSGPPRILILTPTRELAM 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 184 QIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQ 263
Cdd:PRK11192 88 QVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVETLILDEADRMLDMGFAQD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 264 IRKIVSQIRPDRQTLYWSATWPKE-VEQLARQFLFNAYKViigSAD--LKANHAIRQHVEIV-SESQKYNKLVKLLEDiM 339
Cdd:PRK11192 168 IETIAAETRWRKQTLLFSATLEGDaVQDFAERLLNDPVEV---EAEpsRRERKKIHQWYYRAdDLEHKTALLCHLLKQ-P 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 340 DGSRILIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFVINYDFP 419
Cdd:PRK11192 244 EVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMP 323
|
330 340
....*....|....*....|....*...
gi 807045801 420 GSLEDYVHRIGRTGRAGASGTAYTFFTA 447
Cdd:PRK11192 324 RSADTYLHRIGRTGRAGRKGTAISLVEA 351
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
92-471 |
2.70e-85 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 271.02 E-value: 2.70e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 92 PKPIKS-FHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPILDH---G 167
Cdd:PRK01297 82 PQEGKTrFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKErymG 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 168 DgPIVLVLAPTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQ-KGVEIVIATPGRLIDMLESNHTNLRRVTY 246
Cdd:PRK01297 162 E-PRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFNQRGEVHLDMVEV 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 247 LVLDEADRMLDMGFEPQIRKIVSQIRP--DRQTLYWSATWPKEVEQLARQFLFNAYKVIIgSADLKANHAIRQHVEIVSE 324
Cdd:PRK01297 241 MVLDEADRMLDMGFIPQVRQIIRQTPRkeERQTLLFSATFTDDVMNLAKQWTTDPAIVEI-EPENVASDTVEQHVYAVAG 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 325 SQKYNKLVKLLEDiMDGSRILIFMDTKkgcDQVTR---QLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVA 401
Cdd:PRK01297 320 SDKYKLLYNLVTQ-NPWERVMVFANRK---DEVRRieeRLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVA 395
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 402 ARGLDVKDVKFVINYDFPGSLEDYVHRIGRTGRAGASGTAYTFFTAANARFakdLVNILEEAGQKVSPEL 471
Cdd:PRK01297 396 GRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDDAFQ---LPEIEELLGRKISCEM 462
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
97-298 |
2.88e-85 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 262.04 E-value: 2.88e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 97 SFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPILDHGDG-----PI 171
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVGRGrrkayPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 172 VLVLAPTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDE 251
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVLDE 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 807045801 252 ADRMLDMGFEPQIRKIVSQ----IRPDRQTLYWSATWPKEVEQLARQFLFN 298
Cdd:cd17967 161 ADRMLDMGFEPQIRKIVEHpdmpPKGERQTLMFSATFPREIQRLAADFLKN 211
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
107-302 |
2.97e-85 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 261.24 E-value: 2.97e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPIL-DHGDGPIVLVLAPTRELAVQI 185
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPrEQRNGPGVLVLTPTRELALQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 186 QQEATKFGASSrIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIR 265
Cdd:cd17958 81 EAECSKYSYKG-LKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQIR 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 807045801 266 KIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKV 302
Cdd:cd17958 160 KILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
96-444 |
7.51e-85 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 267.99 E-value: 7.51e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 96 KSFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPILD--HGDGPIVL 173
Cdd:PRK04837 8 QKFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPEdrKVNQPRAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 174 VLAPTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEAD 253
Cdd:PRK04837 88 IMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEAD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 254 RMLDMGFEPQIRKIVSQIRP--DRQTLYWSATWPKEVEQLARQFLFNAYKVIIgSADLKANHAIRQHVEIVSESQKYNKL 331
Cdd:PRK04837 168 RMFDLGFIKDIRWLFRRMPPanQRLNMLFSATLSYRVRELAFEHMNNPEYVEV-EPEQKTGHRIKEELFYPSNEEKMRLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 332 VKLLE-DIMDgsRILIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDV 410
Cdd:PRK04837 247 QTLIEeEWPD--RAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAV 324
|
330 340 350
....*....|....*....|....*....|....
gi 807045801 411 KFVINYDFPGSLEDYVHRIGRTGRAGASGTAYTF 444
Cdd:PRK04837 325 THVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
88-300 |
1.07e-81 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 254.51 E-value: 1.07e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 88 GRDVPKPIKSFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQ----PI 163
Cdd:cd18052 35 GRNPPPAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEgltaSS 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 164 LDHGDGPIVLVLAPTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRR 243
Cdd:cd18052 115 FSEVQEPQALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISLSK 194
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 807045801 244 VTYLVLDEADRMLDMGFEPQIRKIVSQI----RPDRQTLYWSATWPKEVEQLARQFLFNAY 300
Cdd:cd18052 195 LKYLILDEADRMLDMGFGPEIRKLVSEPgmpsKEDRQTLMFSATFPEEIQRLAAEFLKEDY 255
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
97-444 |
2.28e-80 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 262.48 E-value: 2.28e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 97 SFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPildhgDGPIVLVLA 176
Cdd:PRK11634 7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPEL-----KAPQILVLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 177 PTRELAVQIQQEATKFGASSRIKNT-CIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRM 255
Cdd:PRK11634 82 PTRELAVQVAEAMTDFSKHMRGVNVvALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 256 LDMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKVIIGSAdLKANHAIRQHVEIVSESQKYNKLVKLL 335
Cdd:PRK11634 162 LRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSS-VTTRPDISQSYWTVWGMRKNEALVRFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 336 EdIMDGSRILIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFVIN 415
Cdd:PRK11634 241 E-AEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVN 319
|
330 340
....*....|....*....|....*....
gi 807045801 416 YDFPGSLEDYVHRIGRTGRAGASGTAYTF 444
Cdd:PRK11634 320 YDIPMDSESYVHRIGRTGRAGRAGRALLF 348
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
107-296 |
7.21e-78 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 243.00 E-value: 7.21e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPILDH---GDGPIVLVLAPTRELAV 183
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEetkDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 184 QIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQ 263
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEPQ 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 807045801 264 IRKI-----VSQIRPD---------------RQTLYWSATWPKEVEQLARQFL 296
Cdd:cd17945 161 VTKIldampVSNKKPDteeaeklaasgkhryRQTMMFTATMPPAVEKIAKGYL 213
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
88-298 |
4.97e-77 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 241.87 E-value: 4.97e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 88 GRDVPKPIKSFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIV------HVNAQ 161
Cdd:cd18051 13 GENCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSqiyeqgPGESL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 162 PILDHGDG-----PIVLVLAPTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLES 236
Cdd:cd18051 93 PSESGYYGrrkqyPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLER 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 807045801 237 NHTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQI----RPDRQTLYWSATWPKEVEQLARQFLFN 298
Cdd:cd18051 173 GKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDtmppTGERQTLMFSATFPKEIQMLARDFLDN 238
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
95-458 |
4.02e-72 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 234.34 E-value: 4.02e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 95 IKSFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPILDHgdgpiVLV 174
Cdd:PTZ00424 27 VDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQ-----ALI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 175 LAPTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADR 254
Cdd:PTZ00424 102 LAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 255 MLDMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKVIIGSADLKAnHAIRQ-HVEIVSESQKYNKLVK 333
Cdd:PTZ00424 182 MLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTL-EGIRQfYVAVEKEEWKFDTLCD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 334 LLEDIMDGSRIlIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFV 413
Cdd:PTZ00424 261 LYETLTITQAI-IYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLV 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 807045801 414 INYDFPGSLEDYVHRIGRTGRAGASGTAYTFFTAANARFAKDLVN 458
Cdd:PTZ00424 340 INYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIER 384
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
120-291 |
7.45e-65 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 207.48 E-value: 7.45e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 120 TPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNaqpilDHGDGPIVLVLAPTRELAVQIQQEATKFGASSRIK 199
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALD-----KLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 200 NTCIYGGVPKGPQVRDLqKGVEIVIATPGRLIDMLESNHTnLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLY 279
Cdd:pfam00270 76 VASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQERKL-LKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILL 153
|
170
....*....|..
gi 807045801 280 WSATWPKEVEQL 291
Cdd:pfam00270 154 LSATLPRNLEDL 165
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
97-302 |
7.30e-64 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 206.01 E-value: 7.30e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 97 SFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIvhvnaQPILDHGDGPIVLVLA 176
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPIL-----QALLENPQRFFALVLA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 177 PTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLE-SNHTNLRRVTYLVLDEADRM 255
Cdd:cd17954 76 PTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLEnTKGFSLKSLKFLVMDEADRL 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 807045801 256 LDMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKV 302
Cdd:cd17954 156 LNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKI 202
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
111-310 |
4.95e-62 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 201.18 E-value: 4.95e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 111 IEKAGFTEPTPIQAQGWPMALKG-RDLIGIAETGSGKTIAYLLPAIVHvnaqpiLDHGDGPIVLVLAPTRELAVQIQQEA 189
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEA------LKRGKGGRVLVLVPTRELAEQWAEEL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 190 TKFGASSRIKNTCIYGGVPKGPQVRDLQKGV-EIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIRKIV 268
Cdd:smart00487 75 KKLGPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLL 154
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 807045801 269 SQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKVIIGSADLK 310
Cdd:smart00487 155 KLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLE 196
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
107-296 |
9.24e-61 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 198.33 E-value: 9.24e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQ----PILdHGDGPIVLVLAPTRELA 182
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQekklPFI-KGEGPYGLIVCPSRELA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 183 VQIQQEATKF------GASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRML 256
Cdd:cd17951 80 RQTHEVIEYYckalqeGGYPQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMI 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 807045801 257 DMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFL 296
Cdd:cd17951 160 DMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSAL 199
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
315-445 |
1.86e-60 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 194.65 E-value: 1.86e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 315 IRQHVEIVSESQKYNKLVKLLEDIMDGSRILIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPI 394
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 807045801 395 MTATDVAARGLDVKDVKFVINYDFPGSLEDYVHRIGRTGRAGASGTAYTFF 445
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
107-305 |
4.47e-59 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 193.57 E-value: 4.47e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQpilDHGDGPIVLVLAPTRELAVQIQ 186
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKP---RKKKGLRALILAPTRELASQIY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 187 QEATKFGASSRIKNTCIYGG-VPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIR 265
Cdd:cd17957 78 RELLKLSKGTGLRIVLLSKSlEAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQTD 157
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 807045801 266 KIVSQIR-PDRQTLYWSATWPKEVEQLARQFLFNAYKVIIG 305
Cdd:cd17957 158 EILAACTnPNLQRSLFSATIPSEVEELARSVMKDPIRIIVG 198
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
98-300 |
2.43e-58 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 191.67 E-value: 2.43e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 98 FHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPaIVHVNAQpildHGDGPIVLVLAP 177
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALP-ILQRLSE----DPYGIFALVLTP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 178 TRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHT---NLRRVTYLVLDEADR 254
Cdd:cd17955 76 TRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSDDttkVLSRVKFLVLDEADR 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 807045801 255 MLDMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAY 300
Cdd:cd17955 156 LLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
107-303 |
4.38e-57 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 188.56 E-value: 4.38e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMAL-KGRDLIGIAETGSGKTIAYLLPAIVHVNAQPILDHGDGPIVLVLAPTRELAVQI 185
Cdd:cd17964 5 LLKALTRMGFETMTPVQQKTLKPILsTGDDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGRRSGVSALIISPTRELALQI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 186 QQEATKF-GASSRIKNTCIYGGVPKGPQVRDLQK-GVEIVIATPGRLIDMLESNHT--NLRRVTYLVLDEADRMLDMGFE 261
Cdd:cd17964 85 AAEAKKLlQGLRKLRVQSAVGGTSRRAELNRLRRgRPDILVATPGRLIDHLENPGVakAFTDLDYLVLDEADRLLDMGFR 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 807045801 262 PQIRKIVSQIRP----DRQTLYWSATWPKEVEQLARQFLFNAYKVI 303
Cdd:cd17964 165 PDLEQILRHLPEknadPRQTLLFSATVPDEVQQIARLTLKKDYKFI 210
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
107-302 |
6.68e-57 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 187.85 E-value: 6.68e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPildhGDGPI--VLVLAPTRELAVQ 184
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRP----KKKAAtrVLVLVPTRELAMQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 185 IQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHT-NLRRVTYLVLDEADRMLDMGFEPQ 263
Cdd:cd17947 77 CFSVLQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSfDLDSIEILVLDEADRMLEEGFADE 156
|
170 180 190
....*....|....*....|....*....|....*....
gi 807045801 264 IRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKV 302
Cdd:cd17947 157 LKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
107-303 |
3.62e-55 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 183.13 E-value: 3.62e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVnaqpiLDHGDGPIVLVLAPTRELAVQIQ 186
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRC-----LTEHRNPSALILTPTRELAVQIE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 187 QEATKFGASS-RIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIR 265
Cdd:cd17962 76 DQAKELMKGLpPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVL 155
|
170 180 190
....*....|....*....|....*....|....*...
gi 807045801 266 KIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKVI 303
Cdd:cd17962 156 DILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRIT 193
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
107-293 |
1.62e-53 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 179.32 E-value: 1.62e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHV-NAQPILDHGDGPIVLVLAPTRELAVQI 185
Cdd:cd17949 2 VSHLKSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLlSLEPRVDRSDGTLALVLVPTRELALQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 186 QQEATKFGASSR-IKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLES----NHTNLRrvtYLVLDEADRMLDMGF 260
Cdd:cd17949 82 YEVLEKLLKPFHwIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNtqsfDVSNLR---WLVLDEADRLLDMGF 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 807045801 261 EPQIRKIVSQIR-------------PDRQTLYWSATWPKEVEQLAR 293
Cdd:cd17949 159 EKDITKILELLDdkrskaggekskpSRRQTVLVSATLTDGVKRLAG 204
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
107-283 |
5.86e-53 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 178.59 E-value: 5.86e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALK-GRDLIGIAETGSGKTIAYLLPAIVHvnaqpILDHGD---------GPIVLVLA 176
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILER-----LLSQKSsngvggkqkPLRALILT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 177 PTRELAVQIQQEATKFGASSRIKNTCIYGG--VPKgpQVRDLQKGVEIVIATPGRLIDMLESNHT---NLRRVTYLVLDE 251
Cdd:cd17946 76 PTRELAVQVKDHLKAIAKYTNIKIASIVGGlaVQK--QERLLKKRPEIVVATPGRLWELIQEGNEhlaNLKSLRFLVLDE 153
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 807045801 252 ADRMLDMG-FEpQIRKIVSQI-------RPDRQTLYWSAT 283
Cdd:cd17946 154 ADRMLEKGhFA-ELEKILELLnkdragkKRKRQTFVFSAT 192
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
97-293 |
1.49e-51 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 174.03 E-value: 1.49e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 97 SFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNA-QPILdhgdGPIVLVL 175
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAhSPTV----GARALIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 176 APTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRM 255
Cdd:cd17959 78 SPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRL 157
|
170 180 190
....*....|....*....|....*....|....*...
gi 807045801 256 LDMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLAR 293
Cdd:cd17959 158 FEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAK 195
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
108-293 |
2.06e-50 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 171.00 E-value: 2.06e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 108 LQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAI---VHVNAQPildhGDGPIVLVLAPTRELAVQ 184
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIellYKLKFKP----RNGTGVIIISPTRELALQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 185 IQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESN----HTNLRrvtYLVLDEADRMLDMGF 260
Cdd:cd17942 78 IYGVAKELLKYHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTkgflYKNLQ---CLIIDEADRILEIGF 154
|
170 180 190
....*....|....*....|....*....|...
gi 807045801 261 EPQIRKIVSQIRPDRQTLYWSATWPKEVEQLAR 293
Cdd:cd17942 155 EEEMRQIIKLLPKRRQTMLFSATQTRKVEDLAR 187
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
107-302 |
1.22e-48 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 166.21 E-value: 1.22e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPILDHGDGPIVLVLAPTRELAVQIQ 186
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANLKKGQVGALIISPTRELATQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 187 QEATKF--GASSRIKNTCIYGGVPKGPQVRDL-QKGVEIVIATPGRLIDMLESNHT--NLRRVTYLVLDEADRMLDMGFE 261
Cdd:cd17960 81 EVLQSFleHHLPKLKCQLLIGGTNVEEDVKKFkRNGPNILVGTPGRLEELLSRKADkvKVKSLEVLVLDEADRLLDLGFE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 807045801 262 PQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKV 302
Cdd:cd17960 161 ADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRV 201
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
111-298 |
6.85e-47 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 161.69 E-value: 6.85e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 111 IEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPiLDHGDGPIVLVLAPTRELAVQIQQEAT 190
Cdd:cd17941 5 LKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRER-WTPEDGLGALIISPTRELAMQIFEVLR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 191 KFGASSRIKNTCIYGGvpkgpqvRDLQK------GVEIVIATPGRLIDMLESNH----TNLRrvtYLVLDEADRMLDMGF 260
Cdd:cd17941 84 KVGKYHSFSAGLIIGG-------KDVKEekerinRMNILVCTPGRLLQHMDETPgfdtSNLQ---MLVLDEADRILDMGF 153
|
170 180 190
....*....|....*....|....*....|....*...
gi 807045801 261 EPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFN 298
Cdd:cd17941 154 KETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKN 191
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
98-302 |
7.44e-46 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 159.00 E-value: 7.44e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 98 FHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNaqPILDHgdgpI-VLVLA 176
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKID--PKKDV----IqALILV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 177 PTRELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRML 256
Cdd:cd17940 75 PTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLL 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 807045801 257 DMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKV 302
Cdd:cd17940 155 SQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
107-302 |
8.38e-41 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 145.10 E-value: 8.38e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAqpildHGDGPIVLVLAPTRELAVQIQ 186
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDL-----ERRHPQVLILAPTREIAVQIH 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 187 QEATKFGASSRIKNTCIY-GGVPKGPQVRDLqKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIR 265
Cdd:cd17943 76 DVFKKIGKKLEGLKCEVFiGGTPVKEDKKKL-KGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDVN 154
|
170 180 190
....*....|....*....|....*....|....*..
gi 807045801 266 KIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKV 302
Cdd:cd17943 155 WIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
100-303 |
1.05e-40 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 145.16 E-value: 1.05e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 100 DVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPildhgDGPIVLVLAPTR 179
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTV-----RETQALVLAPTR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 180 ELAVQIQQEATKFGASSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMG 259
Cdd:cd17939 76 ELAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRG 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 807045801 260 FEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKVI 303
Cdd:cd17939 156 FKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRIL 199
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
107-299 |
3.78e-40 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 143.88 E-value: 3.78e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIvhvnaQPILDH------GDGPIVLVLAPTRE 180
Cdd:cd17961 5 LLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPII-----QKILKAkaesgeEQGTRALILVPTRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 181 LAVQIQQEATKFGA--SSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHT-NLRRVTYLVLDEADRMLD 257
Cdd:cd17961 80 LAQQVSKVLEQLTAycRKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLlLLSTLKYLVIDEADLVLS 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 807045801 258 MGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNA 299
Cdd:cd17961 160 YGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNP 201
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
98-299 |
3.42e-39 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 141.30 E-value: 3.42e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 98 FHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAqpildhgdgpivLVLAP 177
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVVA------------LILEP 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 178 TRELAVQIQQEATKFGA---SSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADR 254
Cdd:cd17938 69 SRELAEQTYNCIENFKKyldNPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADR 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 807045801 255 MLDMGFEPQIRKIVSQI-----RPDR-QTLYWSATWPK-EVEQLARQFLFNA 299
Cdd:cd17938 149 LLSQGNLETINRIYNRIpkitsDGKRlQVIVCSATLHSfEVKKLADKIMHFP 200
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
108-303 |
4.51e-39 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 140.75 E-value: 4.51e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 108 LQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAI--VHVNAQPIlDHGDGPIVLVLAPTRELAVQI 185
Cdd:cd17944 2 IKLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIekLQEDQQPR-KRGRAPKVLVLAPTRELANQV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 186 QQEATKFgaSSRIKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIR 265
Cdd:cd17944 81 TKDFKDI--TRKLSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVE 158
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 807045801 266 KIVS-QIRPDR----QTLYWSATWPKEVEQLARQFLFNAYKVI 303
Cdd:cd17944 159 EILSvSYKKDSednpQTLLFSATCPDWVYNVAKKYMKSQYEQV 201
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
107-302 |
8.56e-38 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 137.32 E-value: 8.56e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKG--RDLIGIAETGSGKTIAYLLPAIVHVNaqPILDHgdgPIVLVLAPTRELAVQ 184
Cdd:cd17963 5 LLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVD--PTLKS---PQALCLAPTRELARQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 185 IQQEATKFGASSRIKNTCIYggvpKGPQVRDLQKGVE-IVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDM-GFEP 262
Cdd:cd17963 80 IGEVVEKMGKFTGVKVALAV----PGNDVPRGKKITAqIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTqGHGD 155
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 807045801 263 QIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKV 302
Cdd:cd17963 156 QSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
107-291 |
1.76e-37 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 137.50 E-value: 1.76e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPILDHG--DGPIVLVLAPTRELAVQ 184
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGpfNAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 185 IQQEATKFGASSRIKNTCIYGGVPKGpQVRDLQKG-VEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQ 263
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITGGRTKR-QIRNPHFEeVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNEK 159
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 807045801 264 IRKIVSQI----RPDRQTLYW---------SATWPKEVEQL 291
Cdd:cd17948 160 LSHFLRRFplasRRSENTDGLdpgtqlvlvSATMPSGVGEV 200
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
98-303 |
7.00e-35 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 129.49 E-value: 7.00e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 98 FHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIvhvnaQPILDHGDGPIVLVLAP 177
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISIL-----QQIDTSLKATQALVLAP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 178 TRELAVQIQQEATKFGASSRIK-NTCIyGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRML 256
Cdd:cd18046 76 TRELAQQIQKVVMALGDYMGIKcHACI-GGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEML 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 807045801 257 DMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKVI 303
Cdd:cd18046 155 SRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRIL 201
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
102-298 |
4.24e-34 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 127.46 E-value: 4.24e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 102 GFPDYVLQ-EIEKA----GFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLpAIVHVnaqpiLDHGDGPI-VLVL 175
Cdd:cd17950 3 GFRDFLLKpELLRAivdcGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVL-STLQQ-----LEPVDGQVsVLVI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 176 APTRELAVQIQQEATKFGAS-SRIKNTCIYGGVPKGPQVRDLQKGV-EIVIATPGRLIDMLESNHTNLRRVTYLVLDEAD 253
Cdd:cd17950 77 CHTRELAFQISNEYERFSKYmPNVKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSHVKHFVLDECD 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 807045801 254 RML-DMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFN 298
Cdd:cd17950 157 KMLeQLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQD 202
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
326-436 |
7.53e-34 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 123.47 E-value: 7.53e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 326 QKYNKLVKLLEDiMDGSRILIFMDTKKGCDqvTRQL-RMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARG 404
Cdd:pfam00271 1 EKLEALLELLKK-ERGGKVLIFSQTKKTLE--AELLlEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERG 77
|
90 100 110
....*....|....*....|....*....|..
gi 807045801 405 LDVKDVKFVINYDFPGSLEDYVHRIGRTGRAG 436
Cdd:pfam00271 78 LDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
98-303 |
6.08e-33 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 124.12 E-value: 6.08e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 98 FHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIvhvnaQPILDHGDGPIVLVLAP 177
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVL-----QCLDIQVRETQALILSP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 178 TRELAVQIQQEATKFGASSRIK-NTCIyGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRML 256
Cdd:cd18045 76 TRELAVQIQKVLLALGDYMNVQcHACI-GGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEML 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 807045801 257 DMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFLFNAYKVI 303
Cdd:cd18045 155 NKGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRIL 201
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
355-436 |
9.56e-29 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 108.45 E-value: 9.56e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 355 DQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFVINYDFPGSLEDYVHRIGRTGR 434
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 807045801 435 AG 436
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
107-298 |
2.02e-26 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 106.95 E-value: 2.02e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIEKAGFTEPTPIQAQGWPMALKG---------RDLIGIAETGSGKTIAYLLPaIVHvnaqpILDHGDGPIV--LVL 175
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLP-IVQ-----ALSKRVVPRLraLIV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 176 APTRELAVQIQQEATKFGASSRIKnTCIYGG----------VPKGPqVRDLQKGVEIVIATPGRLIDMLESNHT-NLRRV 244
Cdd:cd17956 75 VPTKELVQQVYKVFESLCKGTGLK-VVSLSGqksfkkeqklLLVDT-SGRYLSRVDILVATPGRLVDHLNSTPGfTLKHL 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 807045801 245 TYLVLDEADRMLD----------------------MGFEPQIRKIVSQIRPdrQTLYWSATWPKEVEQLARQFLFN 298
Cdd:cd17956 153 RFLVIDEADRLLNqsfqdwletvmkalgrptapdlGSFGDANLLERSVRPL--QKLLFSATLTRDPEKLSSLKLHR 226
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
140-295 |
8.05e-25 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 103.23 E-value: 8.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 140 AETGSGKTIAYLLPAI-------------VHVNAQPILDHGDgPIVLVLAPTRELAVQIQQEATKFGASSRIKNTCIYGG 206
Cdd:cd17965 68 AETGSGKTLAYLAPLLdylkrqeqepfeeAEEEYESAKDTGR-PRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSG 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 207 vpKGPQVRDLQ----KGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLYWSA 282
Cdd:cd17965 147 --FGPSYQRLQlafkGRIDILVTTPGKLASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSA 224
|
170
....*....|....
gi 807045801 283 TWPKEVEQ-LARQF 295
Cdd:cd17965 225 TIPKEFDKtLRKLF 238
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
130-445 |
7.60e-23 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 101.37 E-value: 7.60e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 130 ALKGRDLIGIAETGSGKTIAYLLPAIVhvnaqpildhGDGPIVLV--LaptreLAV---QIQQeATKFGassrIKNTCIY 204
Cdd:COG0514 29 VLAGRDALVVMPTGGGKSLCYQLPALL----------LPGLTLVVspL-----IALmkdQVDA-LRAAG----IRAAFLN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 205 GGVPKGPQ---VRDLQKG-VEIVIATPGRL-----IDMLESnhtnlRRVTYLVLDEA--------DrmldmgFEP---QI 264
Cdd:COG0514 89 SSLSAEERrevLRALRAGeLKLLYVAPERLlnprfLELLRR-----LKISLFAIDEAhcisqwghD------FRPdyrRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 265 RKIVSQIrPDRQTLYWSATWPKEVEQ-LARQFLFNAYKVIIGSADlKANhaIRQHVEIVSESQKYNKLVKLLEDIMDGSR 343
Cdd:COG0514 158 GELRERL-PNVPVLALTATATPRVRAdIAEQLGLEDPRVFVGSFD-RPN--LRLEVVPKPPDDKLAQLLDFLKEHPGGSG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 344 IlIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATdVA-ARGLDVKDVKFVINYDFPGSL 422
Cdd:COG0514 234 I-VYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT-IAfGMGIDKPDVRFVIHYDLPKSI 311
|
330 340
....*....|....*....|...
gi 807045801 423 EDYVHRIGRTGRAGASGTAYTFF 445
Cdd:COG0514 312 EAYYQEIGRAGRDGLPAEALLLY 334
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
89-296 |
6.26e-21 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 91.62 E-value: 6.26e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 89 RDVPKP---IKSFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKG--RDLIGIAETGSGKTIAYLLPAIVHVNAQPI 163
Cdd:cd18048 8 RDPTSPlfsVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 164 LdhgdgPIVLVLAPTRELAVQ---IQQEATKFGASSRIKNTCIYGGVPKGPQVRdlqkgVEIVIATPGRLID-MLESNHT 239
Cdd:cd18048 88 Y-----PQCLCLSPTFELALQtgkVVEEMGKFCVGIQVIYAIRGNRPGKGTDIE-----AQIVIGTPGTVLDwCFKLRLI 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 807045801 240 NLRRVTYLVLDEADRMLDM-GFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQFL 296
Cdd:cd18048 158 DVTNISVFVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIV 215
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
132-431 |
3.59e-19 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 90.47 E-value: 3.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 132 KGRDLIGIAETGSGKTIayllpaivhVNAQPILDHGDGPIVLVLAPTRELAVQIQQEATKFgassrikntciYGGVPKGP 211
Cdd:COG1061 99 GGGRGLVVAPTGTGKTV---------LALALAAELLRGKRVLVLVPRRELLEQWAEELRRF-----------LGDPLAGG 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 212 QVRDLQKgvEIVIATPGRLIDMLESNHTNlRRVTYLVLDEADRmldmGFEPQIRKIVSQI-------------RPDRQTL 278
Cdd:COG1061 159 GKKDSDA--PITVATYQSLARRAHLDELG-DRFGLVIIDEAHH----AGAPSYRRILEAFpaayrlgltatpfRSDGREI 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 279 YW--------SATWPkevEQLARQFLFNAYKVIIG---SADLKANHAIRQHVE---IVSESQKYNKLVKLLEDIMDGSRI 344
Cdd:COG1061 232 LLflfdgivyEYSLK---EAIEDGYLAPPEYYGIRvdlTDERAEYDALSERLRealAADAERKDKILRELLREHPDDRKT 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 345 LIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFVINYDFPGSLED 424
Cdd:COG1061 309 LVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPRE 388
|
....*..
gi 807045801 425 YVHRIGR 431
Cdd:COG1061 389 FIQRLGR 395
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
133-283 |
1.61e-16 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 76.29 E-value: 1.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 133 GRDLIGIAETGSGKTIAYLLPAIVHVNAQpildhgdGPIVLVLAPTRELAVQIQQEatkFGASSRIKNTC--IYGGVPKG 210
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLKK-------GKKVLVLVPTKALALQTAER---LRELFGPGIRVavLVGGSSAE 70
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 807045801 211 PQVRDLQKGVEIVIATPGRLIDMLESNHTN-LRRVTYLVLDEADRMLDMGFEPQIRK--IVSQIRPDRQTLYWSAT 283
Cdd:cd00046 71 EREKNKLGDADIIIATPDMLLNLLLREDRLfLKDLKLIIVDEAHALLIDSRGALILDlaVRKAGLKNAQVILLSAT 146
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
305-437 |
4.82e-14 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 74.77 E-value: 4.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 305 GSADLKANHAIRQHVEIVSESQ----KYNKLVKLLEDIMD---GSRILIFMDTKKGCDQVTRQLRMDGWPAL------SI 371
Cdd:COG1111 310 ASKRLVSDPRFRKAMRLAEEADiehpKLSKLREILKEQLGtnpDSRIIVFTQYRDTAEMIVEFLSEPGIKAGrfvgqaSK 389
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 807045801 372 HGDK--SQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFVINYDfPGSLE-DYVHRIGRTGRAGA 437
Cdd:COG1111 390 EGDKglTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYE-PVPSEiRSIQRKGRTGRKRE 457
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
96-294 |
5.86e-14 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 70.90 E-value: 5.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 96 KSFHDVGFPDYVLQEIEKAGFTEPTPIQAQGWPMALKG--RDLIGIAETGSGKTIAYLLPAIVHVNAQPILDHgdgpiVL 173
Cdd:cd18047 1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQ-----CL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 174 VLAPTRELAVQ---IQQEATKFGASSRIKNTCIYGGVPKGPQVRDlqkgvEIVIATPGRLID-MLESNHTNLRRVTYLVL 249
Cdd:cd18047 76 CLSPTYELALQtgkVIEQMGKFYPELKLAYAVRGNKLERGQKISE-----QIVIGTPGTVLDwCSKLKFIDPKKIKVFVL 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 807045801 250 DEADRML-DMGFEPQIRKIVSQIRPDRQTLYWSATWPKEVEQLARQ 294
Cdd:cd18047 151 DEADVMIaTQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQK 196
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
103-443 |
1.22e-13 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 73.33 E-value: 1.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 103 FPDYVLQEI----EKAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIvhvnaQPILDHGdGPIVLVLAPT 178
Cdd:COG1205 37 WPDWLPPELraalKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVL-----EALLEDP-GATALYLYPT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 179 RELAV-Q---IQQEATKFGAssRIKNTCIYGGVPkgPQVRD-LQKGVEIVIATPgrliDMLES----NHTN----LRRVT 245
Cdd:COG1205 111 KALARdQlrrLRELAEALGL--GVRVATYDGDTP--PEERRwIREHPDIVLTNP----DMLHYgllpHHTRwarfFRNLR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 246 YLVLDEA---------------DRML----DMGFEPQIrkIVSqirpdrqtlywSATW--PKEveqLARQFLFNAYKVII 304
Cdd:COG1205 183 YVVIDEAhtyrgvfgshvanvlRRLRricrHYGSDPQF--ILA-----------SATIgnPAE---HAERLTGRPVTVVD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 305 GSAdlkANHAIRQHV----EIVSESQKYNKL---VKLLEDIM-DGSRILIFMDTKKGCDQVTRQLR---MDGWPALSIHG 373
Cdd:COG1205 247 EDG---SPRGERTFVlwnpPLVDDGIRRSALaeaARLLADLVrEGLRTLVFTRSRRGAELLARYARralREPDLADRVAA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 374 --------DKSQAERDwvlseFKAGKSPIMTAT-------DVAarGLDVkdvkfVINYDFPGSLEDYVHRIGRTGRAGAS 438
Cdd:COG1205 324 yragylpeERREIERG-----LRSGELLGVVSTnalelgiDIG--GLDA-----VVLAGYPGTRASFWQQAGRAGRRGQD 391
|
....*
gi 807045801 439 GTAYT 443
Cdd:COG1205 392 SLVVL 396
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
343-436 |
1.71e-13 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 67.23 E-value: 1.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 343 RILIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFVINYDFPGSL 422
Cdd:cd18794 32 SGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSM 111
|
90
....*....|....
gi 807045801 423 EDYVHRIGRTGRAG 436
Cdd:cd18794 112 ESYYQESGRAGRDG 125
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
104-436 |
4.13e-11 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 65.30 E-value: 4.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 104 PDYVLQEIEKAGFTEPTPIQAQGWPMAL-KGRDLIGIAETGSGKT-IAYLlpAIVHVNAQpildhgdGPIVLVLAPTREL 181
Cdd:COG1204 8 LEKVIEFLKERGIEELYPPQAEALEAGLlEGKNLVVSAPTASGKTlIAEL--AILKALLN-------GGKALYIVPLRAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 182 AVQIQQEATKFGASSRIKNTCIYGGVPKGPqvRDLQKgVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEA------DRm 255
Cdd:COG1204 79 ASEKYREFKRDFEELGIKVGVSTGDYDSDD--EWLGR-YDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAhliddeSR- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 256 ldmGfePQIRKIVSQIR---PDRQTLYWSATWPkEVEQLARqfLFNAykVIIGSA----DLKANHAIRQHVEIVSESQKY 328
Cdd:COG1204 155 ---G--PTLEVLLARLRrlnPEAQIVALSATIG-NAEEIAE--WLDA--ELVKSDwrpvPLNEGVLYDGVLRFDDGSRRS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 329 -NKLVKLLED-IMDGSRILIFMDTKKGC----------------DQVTRQLRMDGWPALSI------------------- 371
Cdd:COG1204 225 kDPTLALALDlLEEGGQVLVFVSSRRDAeslakkladelkrrltPEEREELEELAEELLEVseethtnekladclekgva 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 807045801 372 --HGDKSQAERDWVLSEFKAGKSPIMTATD-------VAARGLDVKDVKFVINYDFPGSleDYVHRIGRTGRAG 436
Cdd:COG1204 305 fhHAGLPSELRRLVEDAFREGLIKVLVATPtlaagvnLPARRVIIRDTKRGGMVPIPVL--EFKQMAGRAGRPG 376
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
104-449 |
1.89e-10 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 63.19 E-value: 1.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 104 PDYVLQEIekAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHvnaqpildhgDGpIVLVLAPTRELAV 183
Cdd:PRK11057 13 AKQVLQET--FGYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVL----------DG-LTLVVSPLISLMK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 184 -QIQQ-EATKFGAS------SRIKNTCIYGGVPKGpQVRdlqkgveIVIATPGRLI--DMLES-NHTNLrrvTYLVLDEA 252
Cdd:PRK11057 80 dQVDQlLANGVAAAclnstqTREQQLEVMAGCRTG-QIK-------LLYIAPERLMmdNFLEHlAHWNP---ALLAVDEA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 253 DRMLDMG--FEPQIRKIvSQIR---PDRQTLYWSATWPKEVEQ-LARQFLFNAYKVIIGSADlKANhaIRqhVEIVSESQ 326
Cdd:PRK11057 149 HCISQWGhdFRPEYAAL-GQLRqrfPTLPFMALTATADDTTRQdIVRLLGLNDPLIQISSFD-RPN--IR--YTLVEKFK 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 327 KYNKLVKLLEDIMDGSRIlIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLD 406
Cdd:PRK11057 223 PLDQLMRYVQEQRGKSGI-IYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGIN 301
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 807045801 407 VKDVKFVINYDFPGSLEDYVHRIGRTGRAGASGTAYTFFTAAN 449
Cdd:PRK11057 302 KPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDPAD 344
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
307-437 |
1.69e-09 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 60.27 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 307 ADLKANHAIRQHVEIVSESQKYNKLVKLLEDIM---DGSRILIFMDTKKGCDQVTRQLRMDGWPAL------SIHGDK-- 375
Cdd:PRK13766 328 EDPRFRKAVRKAKELDIEHPKLEKLREIVKEQLgknPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVrfvgqaSKDGDKgm 407
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 807045801 376 SQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFVINYDFPGSLEDYVHRIGRTGRAGA 437
Cdd:PRK13766 408 SQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYEPVPSEIRSIQRKGRTGRQEE 469
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
311-432 |
3.90e-09 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 59.08 E-value: 3.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 311 ANH---AIRQHVEIVSESQKYNKLVKLLEDIMD-GSRILIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSE 386
Cdd:COG0553 515 CSHpalLLEEGAELSGRSAKLEALLELLEELLAeGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDR 594
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 807045801 387 FKAGKSP--IMTATDVAARGLDVKDVKFVINYDF---PGSLE---DYVHRIGRT 432
Cdd:COG0553 595 FQEGPEApvFLISLKAGGEGLNLTAADHVIHYDLwwnPAVEEqaiDRAHRIGQT 648
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
394-446 |
4.50e-09 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 53.09 E-value: 4.50e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 807045801 394 IMTATDVAARGLDVKDVKFVINYDFPGSLEDYVHRIGRTGRAGASGTAYTFFT 446
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVILFV 77
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
318-430 |
1.02e-08 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 53.63 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 318 HVEIVSesQKYNKLVKLLEDI-MDGSRILIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSP--I 394
Cdd:cd18793 5 IEEVVS--GKLEALLELLEELrEPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIrvF 82
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 807045801 395 MTATDVAARGLDVKDVKFVINYDF---PGSLE---DYVHRIG 430
Cdd:cd18793 83 LLSTKAGGVGLNLTAANRVILYDPwwnPAVEEqaiDRAHRIG 124
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
123-252 |
1.59e-08 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 54.13 E-value: 1.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 123 QAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPildhgdGPIVLVLAPTRELAvQIQQEA-TKFGAS--SRIK 199
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDP------GSRALYLYPTKALA-QDQLRSlRELLEQlgLGIR 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 807045801 200 NTCIYGGVPKGPQVRDLQKGVEIVIATPgrliDMLES----NHTN----LRRVTYLVLDEA 252
Cdd:cd17923 78 VATYDGDTPREERRAIIRNPPRILLTNP----DMLHYallpHHDRwarfLRNLRYVVLDEA 134
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
120-252 |
4.09e-08 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 53.03 E-value: 4.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 120 TPIQAQGWPMALKGRD--LIGiAETGSGKT-IAYLlpAIVHVNAQpildhgDGPIVLVLAPTRELAVQIQQEATKFGASS 196
Cdd:cd17921 3 NPIQREALRALYLSGDsvLVS-APTSSGKTlIAEL--AILRALAT------SGGKAVYIAPTRALVNQKEADLRERFGPL 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 807045801 197 RIKNTCIYG-GVPKGPQVRDLQkgveIVIATPGRLIDMLESNHT-NLRRVTYLVLDEA 252
Cdd:cd17921 74 GKNVGLLTGdPSVNKLLLAEAD----ILVATPEKLDLLLRNGGErLIQDVRLVVVDEA 127
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
131-436 |
5.48e-08 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 55.67 E-value: 5.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 131 LKGRDLIGIAETGSGKTIAYLLPAIVHvnaqpildhgdGPIVLVLAPTRELavqIQQEATKFgASSRIKNTCIYGGVPKG 210
Cdd:PLN03137 473 MSGYDVFVLMPTGGGKSLTYQLPALIC-----------PGITLVISPLVSL---IQDQIMNL-LQANIPAASLSAGMEWA 537
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 211 PQVRDLQK------GVEIVIATPGRLI--DMLESNHTNLRRVTYL---VLDEADRMLDMG--FEPQIRK--IVSQIRPDR 275
Cdd:PLN03137 538 EQLEILQElsseysKYKLLYVTPEKVAksDSLLRHLENLNSRGLLarfVIDEAHCVSQWGhdFRPDYQGlgILKQKFPNI 617
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 276 QTLYWSATWPKEVEQLARQFLfnaykviigsadlkanhairQHVEIVSESQKYN----------KLVKLLEDI------- 338
Cdd:PLN03137 618 PVLALTATATASVKEDVVQAL--------------------GLVNCVVFRQSFNrpnlwysvvpKTKKCLEDIdkfiken 677
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 339 -MDGSRIlIFMDTKKGCDQVTRQLRMDGWPALSIHGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDVKDVKFVINYD 417
Cdd:PLN03137 678 hFDECGI-IYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHS 756
|
330
....*....|....*....
gi 807045801 418 FPGSLEDYVHRIGRTGRAG 436
Cdd:PLN03137 757 LPKSIEGYHQECGRAGRDG 775
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
116-187 |
6.61e-08 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 55.11 E-value: 6.61e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 807045801 116 FTEPTPIQAQGWPMALKGRD-LIgIAETGSGKTIAYLLPAIVH-VNAQPILDHGDGPIVLVLAPTRELAVQIQQ 187
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGEStLL-IAPTGSGKTLAAFLPALDElARRPRPGELPDGLRVLYISPLKALANDIER 94
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
334-434 |
1.14e-07 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 51.11 E-value: 1.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 334 LLEDIMDGSRILIFMDTKKGCDQVTRQLRM---DGWPALSI---HGDKSQAERDWVLSEFKAGKSPIMTATDVAARGLDV 407
Cdd:cd18796 31 VIFLLERHKSTLVFTNTRSQAERLAQRLRElcpDRVPPDFIalhHGSLSRELREEVEAALKRGDLKVVVATSSLELGIDI 110
|
90 100
....*....|....*....|....*..
gi 807045801 408 KDVKFVINYDFPGSLEDYVHRIGRTGR 434
Cdd:cd18796 111 GDVDLVIQIGSPKSVARLLQRLGRSGH 137
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
330-446 |
1.20e-07 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 50.67 E-value: 1.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 330 KLVKLLEDIM------DGSRILIFMDTKKGCDQVTRQLR-----MDGWPALSI--HGDKSQAERDW--------VLSEFK 388
Cdd:cd18802 8 KLQKLIEILReyfpktPDFRGIIFVERRATAVVLSRLLKehpstLAFIRCGFLigRGNSSQRKRSLmtqrkqkeTLDKFR 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 807045801 389 AGKSPIMTATDVAARGLDVKDVKFVINYDFPGSLEDYVHRigRtGRAGASGTAYTFFT 446
Cdd:cd18802 88 DGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQS--R-GRARAPNSKYILMV 142
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
327-434 |
3.29e-07 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 49.66 E-value: 3.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 327 KYNKLVKLL------EDIMDGSRILIFMDTKKGCDQVTRQLRMDGW---PALSI-HGDK------SQAERDWVLSEFKAG 390
Cdd:cd18801 10 KLEKLEEIVkehfkkKQEGSDTRVIIFSEFRDSAEEIVNFLSKIRPgirATRFIgQASGksskgmSQKEQKEVIEQFRKG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 807045801 391 KSPIMTATDVAARGLDVKDVKFVINYDFPGSLEDYVHRIGRTGR 434
Cdd:cd18801 90 GYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR 133
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
118-251 |
5.02e-07 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 50.17 E-value: 5.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 118 EPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPilDHGDGPIVLVLAPTRELavqIQQEATKFGASSR 197
Cdd:cd18036 2 ELRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEKRR--SAGEKGRVVVLVNKVPL---VEQQLEKFFKYFR 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 198 --IKNTCIYGGVPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTNLR----RVTYLVLDE 251
Cdd:cd18036 77 kgYKVTGLSGDSSHKVSFGQIVKASDVIICTPQILINNLLSGREEERvylsDFSLLIFDE 136
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
115-295 |
6.48e-07 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 49.95 E-value: 6.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 115 GFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIvhvnaqpILDHGDGPIVLVLAPTreLAVQIQQEAtkfGA 194
Cdd:cd18018 9 GHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPAL-------LLRRRGPGLTLVVSPL--IALMKDQVD---AL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 195 SSRIKNTCIYGGVPKGPQVRDLQK----GVEIVIATPGRLID-MLESNHTNLRRVTYLVLDEADRMLDMG--FEP---QI 264
Cdd:cd18018 77 PRAIKAAALNSSLTREERRRILEKlragEVKILYVSPERLVNeSFRELLRQTPPISLLVVDEAHCISEWShnFRPdylRL 156
|
170 180 190
....*....|....*....|....*....|..
gi 807045801 265 RKIVSQIRPDRQTLYWSATWPKEV-EQLARQF 295
Cdd:cd18018 157 CRVLRELLGAPPVLALTATATKRVvEDIASHL 188
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
314-445 |
6.57e-07 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 48.78 E-value: 6.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 314 AIRQHVEIVSESQ-KYNKLVKLLEDIMDGSRILIFMDTKkgcDQVTRQLRMDGWPAlsIHGDKSQAERDWVLSEFKAGKS 392
Cdd:cd18789 21 AHRKRRLLAAMNPnKLRALEELLKRHEQGDKIIVFTDNV---EALYRYAKRLLKPF--ITGETPQSEREEILQNFREGEY 95
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 807045801 393 PIMTATDVAARGLDVKD--VKFVINYDFpGSLEDYVHRIGRTGRAGASGTAYTFF 445
Cdd:cd18789 96 NTLVVSKVGDEGIDLPEanVAIQISGHG-GSRRQEAQRLGRILRPKKGGGKNAFF 149
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
107-290 |
1.62e-05 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 45.60 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 107 VLQEIekAGFTEPTPIQAQGWPMALKGRDLIGIAETGSGKTIAYLLPAIVhvnaqpildhgDGPIVLVLAPTRELaVQIQ 186
Cdd:cd17920 3 ILKEV--FGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALL-----------LDGVTLVVSPLISL-MQDQ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 187 QEATKfgaSSRIKNTCIYGGVPKGPQVRDLQK----GVEIVIATPGRL-----IDMLESNHtNLRRVTYLVLDEADRMLD 257
Cdd:cd17920 69 VDRLQ---QLGIRAAALNSTLSPEEKREVLLRikngQYKLLYVTPERLlspdfLELLQRLP-ERKRLALIVVDEAHCVSQ 144
|
170 180 190
....*....|....*....|....*....|....*...
gi 807045801 258 MG--FEPQIRKIvSQIR---PDRQTLYWSATWPKEVEQ 290
Cdd:cd17920 145 WGhdFRPDYLRL-GRLRralPGVPILALTATATPEVRE 181
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
130-252 |
2.38e-05 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 45.34 E-value: 2.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 130 ALKgRDLIGIAETGSGKT-IAYLLpaIVHVNAQPILDHGDGPIVLVLAPTRELAvqiQQEATKFGASSRIKNTCIYG--G 206
Cdd:cd18034 14 ALK-RNTIVVLPTGSGKTlIAVML--IKEMGELNRKEKNPKKRAVFLVPTVPLV---AQQAEAIRSHTDLKVGEYSGemG 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 807045801 207 VPKGPQVRDLQ--KGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEA 252
Cdd:cd18034 88 VDKWTKERWKEelEKYDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
130-254 |
2.47e-05 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 44.81 E-value: 2.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 130 ALKGRDLIgIAETGSGKTIAYLLPAivhvnaQPILDHGDGPiVLVLAPTRELAVQiQQEATKFGASSRIKNTCIYGGVPk 209
Cdd:cd18035 14 ALNGNTLI-VLPTGLGKTIIAILVA------ADRLTKKGGK-VLILAPSRPLVEQ-HAENLKRVLNIPDKITSLTGEVK- 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 807045801 210 gPQVR-DLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADR 254
Cdd:cd18035 84 -PEERaERWDASKIIVATPQVIENDLLAGRITLDDVSLLIFDEAHH 128
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
130-254 |
3.71e-05 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 44.73 E-value: 3.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 130 ALKGRDLIGIAETGSGKTIAYLLPAIVHVNAQPildHGDGPIVLVLAPTRELavqIQQEATKFGASSRI---KNTCIYGG 206
Cdd:cd17927 14 ALKGKNTIICLPTGSGKTFVAVLICEHHLKKFP---AGRKGKVVFLANKVPL---VEQQKEVFRKHFERpgyKVTGLSGD 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 807045801 207 VPKGPQVRDLQKGVEIVIATPGRLIDMLES-NHTNLRRVTYLVLDEADR 254
Cdd:cd17927 88 TSENVSVEQIVESSDVIIVTPQILVNDLKSgTIVSLSDFSLLVFDECHN 136
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
133-251 |
3.86e-05 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 44.11 E-value: 3.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 133 GRDLIGIAETGSGKTIAYLLPAIVHVNAQPildhGDGPIVLVLAPTRELAVQIQQ------EATKFGASSRIKNtciyGG 206
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEP----EKGVQVLYISPLKALINDQERrleeplDEIDLEIPVAVRH----GD 72
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 807045801 207 VPKGPQVRDLQKGVEIVIATPGRLIDMLESNHTN--LRRVTYLVLDE 251
Cdd:cd17922 73 TSQSEKAKQLKNPPGILITTPESLELLLVNKKLRelFAGLRYVVVDE 119
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
142-283 |
3.90e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 43.83 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 142 TGSGKTIAYLLpAIVHVNAQPildhgdgpiVLVLAPTRELAVQIQQEATKFGASSRIKNtcIYGGvpkgpqVRDLQKGVE 221
Cdd:cd17926 27 TGSGKTLTALA-LIAYLKELR---------TLIVVPTDALLDQWKERFEDFLGDSSIGL--IGGG------KKKDFDDAN 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 807045801 222 IVIATPGRLIDMLESNHTNLRRVTYLVLDEADRmldmGFEPQIRKIVSQIRPDRQtLYWSAT 283
Cdd:cd17926 89 VVVATYQSLSNLAEEEKDLFDQFGLLIVDEAHH----LPAKTFSEILKELNAKYR-LGLTAT 145
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
100-450 |
7.14e-05 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 45.64 E-value: 7.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 100 DVGFPDYVLQEIEKAGFtEPTPIQAQGWPMALKGRDLIGIAETGSGKT-IAYllPAIVHVnaqpiLDHGDGPIVLVlaPT 178
Cdd:PRK01172 5 DLGYDDEFLNLFTGNDF-ELYDHQRMAIEQLRKGENVIVSVPTAAGKTlIAY--SAIYET-----FLAGLKSIYIV--PL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 179 RELAVQIQQEATKFgASSRIKNTCIYGGVPKGPqvrDLQKGVEIVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDM 258
Cdd:PRK01172 75 RSLAMEKYEELSRL-RSLGMRVKISIGDYDDPP---DFIKRYDVVILTSEKADSLIHHDPYIINDVGLIVADEIHIIGDE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 259 GFEPQIRKIVSQIR---PDRQTLYWSATwPKEVEQLARQFLFNAYKVIIGSADLKANHAIRQHVEIVSESQ---KYNKLV 332
Cdd:PRK01172 151 DRGPTLETVLSSARyvnPDARILALSAT-VSNANELAQWLNASLIKSNFRPVPLKLGILYRKRLILDGYERsqvDINSLI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 333 KllEDIMDGSRILIFMDTKKGCDQVTRQL---------------RMDGWPALSI----------HGDKSQAERDWVLSEF 387
Cdd:PRK01172 230 K--ETVNDGGQVLVFVSSRKNAEDYAEMLiqhfpefndfkvsseNNNVYDDSLNemlphgvafhHAGLSNEQRRFIEEMF 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 807045801 388 KAGKSPIMTATDVAARGLD-------VKDV-KFVINYDFPGSLEDYVHRIGRTGRAGASGTAYTFFTAANA 450
Cdd:PRK01172 308 RNRYIKVIVATPTLAAGVNlparlviVRDItRYGNGGIRYLSNMEIKQMIGRAGRPGYDQYGIGYIYAASP 378
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
323-436 |
8.83e-05 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 42.63 E-value: 8.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 323 SESQKYNKLVKLLedIMDGSRILIFMDTKKGCDQVTRQL--RMDGWPAL-----SIHGDKSQAERDWVLSEFKAGKSPIM 395
Cdd:cd18797 19 SARREAARLFADL--VRAGVKTIVFCRSRKLAELLLRYLkaRLVEEGPLaskvaSYRAGYLAEDRREIEAELFNGELLGV 96
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 807045801 396 TATDVAARGLDVKDVKFVINYDFPGSLEDYVHRIGRTGRAG 436
Cdd:cd18797 97 VATNALELGIDIGGLDAVVLAGYPGSLASLWQQAGRAGRRG 137
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
118-192 |
5.19e-04 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 40.86 E-value: 5.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 118 EPTPIQAQ-----------GWPMalkgrDLIGIAETGSGKTIAYLLPAIVHVNAqpildhgdGPIVLVLAPTRELAVQIQ 186
Cdd:cd17918 15 SLTKDQAQaikdiekdlhsPEPM-----DRLLSGDVGSGKTLVALGAALLAYKN--------GKQVAILVPTEILAHQHY 81
|
....*.
gi 807045801 187 QEATKF 192
Cdd:cd17918 82 EEARKF 87
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
131-292 |
7.03e-04 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 40.40 E-value: 7.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 131 LKGRDLIGIAETGSGKTiayLLPAIVHVNAqpILDHGDGpivLVLAPTRELAVQIQQEatkFGASSRIkntciygGVPKG 210
Cdd:cd18028 15 LKGENLLISIPTASGKT---LIAEMAMVNT--LLEGGKA---LYLVPLRALASEKYEE---FKKLEEI-------GLKVG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 211 PQVRDLQKGVE------IVIATPGRLIDMLESNHTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIR---PDRQTLYWS 281
Cdd:cd18028 77 ISTGDYDEDDEwlgdydIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTLESIVARLRrlnPNTQIIGLS 156
|
170
....*....|.
gi 807045801 282 ATWPKeVEQLA 292
Cdd:cd18028 157 ATIGN-PDELA 166
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
132-161 |
1.62e-03 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 41.06 E-value: 1.62e-03
10 20 30
....*....|....*....|....*....|
gi 807045801 132 KGRDLIGIAETGSGKTIAYLLPAIVHVNAQ 161
Cdd:COG1199 32 EGRHLLIEAGTGTGKTLAYLVPALLAARET 61
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
142-283 |
3.57e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 38.42 E-value: 3.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 142 TGSGKT-IAYLLPAIVHvnaqpilDHGDGPIVLVLAPTRELAVQIQQEATKFGassriKNTCIYGGVPKGPQVRDLQKGV 220
Cdd:pfam04851 32 TGSGKTlTAAKLIARLF-------KKGPIKKVLFLVPRKDLLEQALEEFKKFL-----PNYVEIGEIISGDKKDESVDDN 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 807045801 221 EIVIATPGRL--IDMLESNHTNLRRVTYLVLDEADRmldmGFEPQIRKIVSQIRPDRQtLYWSAT 283
Cdd:pfam04851 100 KIVVTTIQSLykALELASLELLPDFFDVIIIDEAHR----SGASSYRNILEYFKPAFL-LGLTAT 159
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
121-252 |
6.11e-03 |
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DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 38.32 E-value: 6.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 121 PIQAQG--WPMALKGRDLIGI-A-ETGSGKT---IAYLLpaivhVNAQpilDHGDGPiVLVLAPTrELAVQIQQEATKFG 193
Cdd:cd18012 7 PYQKEGfnWLSFLRHYGLGGIlAdDMGLGKTlqtLALLL-----SRKE---EGRKGP-SLVVAPT-SLIYNWEEEAAKFA 76
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 807045801 194 ASSRIKntcIYGGVPKGPQVRDLQKGVEIVIATPG---RLIDMLESNHTNlrrvtYLVLDEA 252
Cdd:cd18012 77 PELKVL---VIHGTKRKREKLRALEDYDLVITSYGllrRDIELLKEVKFH-----YLVLDEA 130
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| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
281-436 |
7.60e-03 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 38.56 E-value: 7.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 281 SATWPKEVEQLARQflfNAYKVIIGSADLKANHAIRQHVEIVSESQKYNKLVKLLEDIMDGSRILIFMDTKKGCDQVTRQ 360
Cdd:cd09639 161 SATLPKFLKEYAEK---IGYVEENEPLDLKPNERAPFIKIESDKVGEISSLERLLEFIKKGGSVAIIVNTVDRAQEFYQQ 237
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 807045801 361 LRMDG--WPALSIHG-----DKSQAERDwVLSEFKAGKSPIMTATDVAARGLDVkDVKFVINYDFPGSLedYVHRIGRTG 433
Cdd:cd09639 238 LKEKGpeEEIMLIHSrftekDRAKKEAE-LLLEFKKSEKFVIVATQVIEASLDI-SVDVMITELAPIDS--LIQRLGRLH 313
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...
gi 807045801 434 RAG 436
Cdd:cd09639 314 RYG 316
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