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Conserved domains on  [gi|806954813|gb|AKC08122|]
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chemotaxis protein [Agrobacterium tumefaciens]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 11435591)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
161-595 5.14e-68

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 231.45  E-value: 5.14e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 161 AKLTQIATDISNRSAQQSDDLSDISQRTALITVAAVVLGFITVVVIGYFAISSWLVTPIRGLVGTMQTLAEGNLSVKVEG 240
Cdd:COG0840   71 ALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLAL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 241 TDRRDEVGTMAKAVEVFKDNELKARRLEADAAQVRNQSEAERQRTAEIDRRRAAEMAEATSGLAEGLKHMANGDLSYQLK 320
Cdd:COG0840  151 ALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRID 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 321 TPFSAEFESLRADFNIAVNQLSKTLLSVADVTATIDNGSRELSSSASDLSQRTETQAASLEETAAALDQITSNVSNSTRR 400
Cdd:COG0840  231 VDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAEN 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 401 TEEARIVAVEANRSAQTSGQVVATAVDAMKRIESSSSQISNI--------------IGVIDEIAFQTNLLALNAGVEAAR 466
Cdd:COG0840  311 AQQAAELAEEASELAEEGGEVVEEAVEGIEEIRESVEETAETieelgessqeigeiVDVIDDIAEQTNLLALNAAIEAAR 390

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 467 AGEAGKGFAVVAQEVRELAQRSAQAAKEIKELIRNSADEVQNGVKL--------------VTATGDALKIIESHVIAINT 532
Cdd:COG0840  391 AGEAGRGFAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAmeegseeveegvelVEEAGEALEEIVEAVEEVSD 470

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 806954813 533 QLDAIATSAREQSVGLAEVNSAVNQMDQVTQHNAAMVERATASSASLAGDAEKLRQIVGQFKL 595
Cdd:COG0840  471 LIQEIAAASEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
161-595 5.14e-68

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 231.45  E-value: 5.14e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 161 AKLTQIATDISNRSAQQSDDLSDISQRTALITVAAVVLGFITVVVIGYFAISSWLVTPIRGLVGTMQTLAEGNLSVKVEG 240
Cdd:COG0840   71 ALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLAL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 241 TDRRDEVGTMAKAVEVFKDNELKARRLEADAAQVRNQSEAERQRTAEIDRRRAAEMAEATSGLAEGLKHMANGDLSYQLK 320
Cdd:COG0840  151 ALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRID 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 321 TPFSAEFESLRADFNIAVNQLSKTLLSVADVTATIDNGSRELSSSASDLSQRTETQAASLEETAAALDQITSNVSNSTRR 400
Cdd:COG0840  231 VDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAEN 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 401 TEEARIVAVEANRSAQTSGQVVATAVDAMKRIESSSSQISNI--------------IGVIDEIAFQTNLLALNAGVEAAR 466
Cdd:COG0840  311 AQQAAELAEEASELAEEGGEVVEEAVEGIEEIRESVEETAETieelgessqeigeiVDVIDDIAEQTNLLALNAAIEAAR 390

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 467 AGEAGKGFAVVAQEVRELAQRSAQAAKEIKELIRNSADEVQNGVKL--------------VTATGDALKIIESHVIAINT 532
Cdd:COG0840  391 AGEAGRGFAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAmeegseeveegvelVEEAGEALEEIVEAVEEVSD 470

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 806954813 533 QLDAIATSAREQSVGLAEVNSAVNQMDQVTQHNAAMVERATASSASLAGDAEKLRQIVGQFKL 595
Cdd:COG0840  471 LIQEIAAASEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 348-594 8.90e-65

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 214.46  E-value: 8.90e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813   348 VADVTATIDNGSRELSSSASDLSQRTETQAASLEETAAALDQITSNVSNSTRRTEEARIVAVEANRSAQTSGQVVATAVD 427
Cdd:smart00283   2 VSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813   428 AMKRIESSSSQISNIIGVIDEIAFQTNLLALNAGVEAARAGEAGKGFAVVAQEVRELAQRSAQAAKEIKELIRN------ 501
Cdd:smart00283  82 AVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEiqeetn 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813   502 --------SADEVQNGVKLVTATGDALKIIESHVIAINTQLDAIATSAREQSVGLAEVNSAVNQMDQVTQHNAAMVERAT 573
Cdd:smart00283 162 eavaameeSSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEIS 241

                          250       260
                   ....*....|....*....|.
gi 806954813   574 ASSASLAGDAEKLRQIVGQFK 594
Cdd:smart00283 242 AAAEELSGLAEELDELVERFK 262
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
303-615 3.79e-63

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 219.06  E-value: 3.79e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 303 LAEGLKHMANGDLSYQLKTPFSAEFESLRADFNIAVNQLSKTLLSVADVTATIDNGSRELSSSASDLSQRTETQAASLEE 382
Cdd:PRK15041 225 LIDSIRHIAGGDLVKPIEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEE 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 383 TAAALDQITSNVSNSTRRTEEARIVAVEANRSAQTSGQVVATAVDAMKRIESSSSQISNIIGVIDEIAFQTNLLALNAGV 462
Cdd:PRK15041 305 TAASMEQLTATVKQNAENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAV 384

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 463 EAARAGEAGKGFAVVAQEVRELAQRSAQAAKEIKELIRNSADEVQNGVKLVTATGDALKIIESHVIAINTQLDAIATSAR 542
Cdd:PRK15041 385 EAARAGEQGRGFAVVAGEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASD 464

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 806954813 543 EQSVGLAEVNSAVNQMDQVTQHNAAMVERATASSASLAGDAEKLRQIVGQFKLDGAMASTSTARTAYKPSAPV 615
Cdd:PRK15041 465 EQSRGIDQVGLAVAEMDRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQQQQQQQRETSAVVKTVTPA 537
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 374-573 2.80e-48

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 167.80  E-value: 2.80e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 374 ETQAASLEETAAALDQITSNVSNSTRRTEEARIVAVEANRSAQTSGQVVATAVDAMKRIESSSSQISNIIGVIDEIAFQT 453
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 454 NLLALNAGVEAARAGEAGKGFAVVAQEVRELAQRSAQAAKEIKELIRNSADEVQNGVKLVTATGDALKIIESHVIAINTQ 533
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 806954813 534 LDAIATSAREQSVGLAEVNSAVNQMDQVTQHNAAMVERAT 573
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 407-562 1.14e-37

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 137.95  E-value: 1.14e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813  407 VAVEANRSAQTSGQVVATAVDAMKRIESSSSQISNIIGVIDEIAFQTNLLALNAGVEAARAGEAGKGFAVVAQEVRELAQ 486
Cdd:pfam00015   3 LAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813  487 RSAQAAKEIKELIR--------------NSADEVQNGVKLVTATGDALKIIESHVIAINTQLDAIATSAREQSVGLAEVN 552
Cdd:pfam00015  83 RSAQAAKEIEALIIeiqkqtndstasieSTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVN 162

                         170
                  ....*....|
gi 806954813  553 SAVNQMDQVT 562
Cdd:pfam00015 163 QAVARMDQVT 172
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
161-595 5.14e-68

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 231.45  E-value: 5.14e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 161 AKLTQIATDISNRSAQQSDDLSDISQRTALITVAAVVLGFITVVVIGYFAISSWLVTPIRGLVGTMQTLAEGNLSVKVEG 240
Cdd:COG0840   71 ALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLAL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 241 TDRRDEVGTMAKAVEVFKDNELKARRLEADAAQVRNQSEAERQRTAEIDRRRAAEMAEATSGLAEGLKHMANGDLSYQLK 320
Cdd:COG0840  151 ALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRID 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 321 TPFSAEFESLRADFNIAVNQLSKTLLSVADVTATIDNGSRELSSSASDLSQRTETQAASLEETAAALDQITSNVSNSTRR 400
Cdd:COG0840  231 VDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAEN 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 401 TEEARIVAVEANRSAQTSGQVVATAVDAMKRIESSSSQISNI--------------IGVIDEIAFQTNLLALNAGVEAAR 466
Cdd:COG0840  311 AQQAAELAEEASELAEEGGEVVEEAVEGIEEIRESVEETAETieelgessqeigeiVDVIDDIAEQTNLLALNAAIEAAR 390

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 467 AGEAGKGFAVVAQEVRELAQRSAQAAKEIKELIRNSADEVQNGVKL--------------VTATGDALKIIESHVIAINT 532
Cdd:COG0840  391 AGEAGRGFAVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAmeegseeveegvelVEEAGEALEEIVEAVEEVSD 470

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 806954813 533 QLDAIATSAREQSVGLAEVNSAVNQMDQVTQHNAAMVERATASSASLAGDAEKLRQIVGQFKL 595
Cdd:COG0840  471 LIQEIAAASEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 348-594 8.90e-65

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 214.46  E-value: 8.90e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813   348 VADVTATIDNGSRELSSSASDLSQRTETQAASLEETAAALDQITSNVSNSTRRTEEARIVAVEANRSAQTSGQVVATAVD 427
Cdd:smart00283   2 VSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813   428 AMKRIESSSSQISNIIGVIDEIAFQTNLLALNAGVEAARAGEAGKGFAVVAQEVRELAQRSAQAAKEIKELIRN------ 501
Cdd:smart00283  82 AVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEiqeetn 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813   502 --------SADEVQNGVKLVTATGDALKIIESHVIAINTQLDAIATSAREQSVGLAEVNSAVNQMDQVTQHNAAMVERAT 573
Cdd:smart00283 162 eavaameeSSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEIS 241

                          250       260
                   ....*....|....*....|.
gi 806954813   574 ASSASLAGDAEKLRQIVGQFK 594
Cdd:smart00283 242 AAAEELSGLAEELDELVERFK 262
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
303-615 3.79e-63

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 219.06  E-value: 3.79e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 303 LAEGLKHMANGDLSYQLKTPFSAEFESLRADFNIAVNQLSKTLLSVADVTATIDNGSRELSSSASDLSQRTETQAASLEE 382
Cdd:PRK15041 225 LIDSIRHIAGGDLVKPIEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEE 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 383 TAAALDQITSNVSNSTRRTEEARIVAVEANRSAQTSGQVVATAVDAMKRIESSSSQISNIIGVIDEIAFQTNLLALNAGV 462
Cdd:PRK15041 305 TAASMEQLTATVKQNAENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAV 384

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 463 EAARAGEAGKGFAVVAQEVRELAQRSAQAAKEIKELIRNSADEVQNGVKLVTATGDALKIIESHVIAINTQLDAIATSAR 542
Cdd:PRK15041 385 EAARAGEQGRGFAVVAGEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASD 464

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 806954813 543 EQSVGLAEVNSAVNQMDQVTQHNAAMVERATASSASLAGDAEKLRQIVGQFKLDGAMASTSTARTAYKPSAPV 615
Cdd:PRK15041 465 EQSRGIDQVGLAVAEMDRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQQQQQQQRETSAVVKTVTPA 537
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 307-625 5.33e-59

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 207.55  E-value: 5.33e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 307 LKHMANGDLSYQLKTPFSAEFESLRADFNIAVNQLSKTLLSVADVTATIDNGSRELSSSASDLSQRTETQAASLEETAAA 386
Cdd:PRK15048 227 IREIAGGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAAS 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 387 LDQITSNVSNSTRRTEEARIVAVEANRSAQTSGQVVATAVDAMKRIESSSSQISNIIGVIDEIAFQTNLLALNAGVEAAR 466
Cdd:PRK15048 307 MEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAAR 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 467 AGEAGKGFAVVAQEVRELAQRSAQAAKEIKELIRNSADEVQNGVKLVTATGDALKIIESHVIAINTQLDAIATSAREQSV 546
Cdd:PRK15048 387 AGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSR 466

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 806954813 547 GLAEVNSAVNQMDQVTQHNAAMVERATASSASLAGDAEKLRQIVGQFKLdgamASTSTARTAYKPSAPVRVADNAQPRP 625
Cdd:PRK15048 467 GIDQVALAVSEMDRVTQQNASLVQESAAAAAALEEQASRLTQAVSAFRL----AASPLTNKPQTPSRPASEQPPAQPRL 541
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
310-596 2.02e-54

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 194.52  E-value: 2.02e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 310 MANGDLSYQLKTPFSAEFESLRADFNIAVNQLSKTLLSVADVTATIDNGSRELSSSASDLSQRTETQAASLEETAAALDQ 389
Cdd:PRK09793 228 IAAGNLARPIAVYGRNEITAIFASLKTMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQ 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 390 ITSNVSNSTRRTEEARIVAVEANRSAQTSGQVVATAVDAMKRIESSSSQISNIIGVIDEIAFQTNLLALNAGVEAARAGE 469
Cdd:PRK09793 308 LTATVGQNADNARQASELAKNAATTAQAGGVQVSTMTHTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGE 387

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 470 AGKGFAVVAQEVRELAQRSAQAAKEIKELIRNSADEVQNGVKLVTATGDALKIIESHVIAINTQLDAIATSAREQSVGLA 549
Cdd:PRK09793 388 QGRGFAVVAGEVRNLASRSAQAAKEIKGLIEESVNRVQQGSKLVNNAAATMTDIVSSVTRVNDIMGEIASASEEQRRGIE 467

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 806954813 550 EVNSAVNQMDQVTQHNAAMVERATASSASLAGDAEKLRQIVGQFKLD 596
Cdd:PRK09793 468 QVAQAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAVFTLE 514
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 374-573 2.80e-48

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 167.80  E-value: 2.80e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 374 ETQAASLEETAAALDQITSNVSNSTRRTEEARIVAVEANRSAQTSGQVVATAVDAMKRIESSSSQISNIIGVIDEIAFQT 453
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 454 NLLALNAGVEAARAGEAGKGFAVVAQEVRELAQRSAQAAKEIKELIRNSADEVQNGVKLVTATGDALKIIESHVIAINTQ 533
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 806954813 534 LDAIATSAREQSVGLAEVNSAVNQMDQVTQHNAAMVERAT 573
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 407-562 1.14e-37

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 137.95  E-value: 1.14e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813  407 VAVEANRSAQTSGQVVATAVDAMKRIESSSSQISNIIGVIDEIAFQTNLLALNAGVEAARAGEAGKGFAVVAQEVRELAQ 486
Cdd:pfam00015   3 LAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813  487 RSAQAAKEIKELIR--------------NSADEVQNGVKLVTATGDALKIIESHVIAINTQLDAIATSAREQSVGLAEVN 552
Cdd:pfam00015  83 RSAQAAKEIEALIIeiqkqtndstasieSTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVN 162

                         170
                  ....*....|
gi 806954813  553 SAVNQMDQVT 562
Cdd:pfam00015 163 QAVARMDQVT 172
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 131-297 2.43e-10

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 63.55  E-value: 2.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 131 LGRTASTVDEALASQKAFGTECQPVFAKIGAKLTQIATDISNRSAQQSDDLSDISQRTA-------LITVAAVVLGFITV 203
Cdd:COG4192  260 IGSGEGGLPSLRRDELAAQATLEALAEENNSILEQLRTQISGLVGNSREQLVALNQETAqlvqqsgILLLAIALLSLLLA 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 204 VVIGYFAISSWLVTPIRGLVGTMQTLAEGNLSVKVeGTDRRDEVGTMAKAVEVFKDNELKARRLEADAAQVRNQSEAERq 283
Cdd:COG4192  340 VLINYFYVRRRLVKRLNALSDAMAAIAAGDLDVPI-PVDGNDEIGRIARLLRVFRDQAIEKTQELETEIEERKRIEKNL- 417

                        170
                 ....*....|....
gi 806954813 284 RTAEIDRRRAAEMA 297
Cdd:COG4192  418 RQTQDELIQAAKMA 431
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 186-278 8.03e-08

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 54.97  E-value: 8.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 186 QRTALITVAAVVLGFITVVVIGYFAISSWLVTPIRGLVGTMQTLAEGNLSVKVEgTDRRDEVGTMAKAVEVFKDnELKAR 265
Cdd:COG5000    4 QILFLLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLP-VTGDDEIGELARAFNRMTD-QLKEQ 81

                         90
                 ....*....|...
gi 806954813 266 RLEADAAQVRNQS 278
Cdd:COG5000   82 REELEERRRYLET 94
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
181-608 1.00e-06

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 52.04  E-value: 1.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 181 LSDISQRTALITVAAVVLGFITVVVIGYFAISSWLVTPIRGLVGTMQTLAEGNLSVKVEgTDRRDEVGTMAKAVEVFKDN 260
Cdd:COG2770  202 VLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIP-VSRKDEIGELARAFNRMADS 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 261 ---ELKARRLEADAAQVRNQSEAERQRTAEIDRRRAAEMAEATSGLAEGLKHMANGDLSYQLKTPFSAEFESLRADFNIA 337
Cdd:COG2770  281 lreSIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALL 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 338 VNQLSKTLLSVADVTATIDNGSRELSSSASDLSQRTETQAASLEETAAALDQITSNVSNSTRRTEEARIVAVEANRSAQT 417
Cdd:COG2770  361 LLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALEL 440

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 418 SGQVVATAVDAMKRIESSSSQISNIIGVIDEIAFQTNLLALNAGVEAARAGEAGKGFAVVAQEVRELAQRSAQAAKEIKE 497
Cdd:COG2770  441 AAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLLLLL 520

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 498 LIRNSADEVQNGVKLVTATGDALKIIESHVIAINTQLDAIATSAREQSVGLAEVNSAVNQMDQVTQHNAAMVERATASSA 577
Cdd:COG2770  521 LEAEALEVAEELLELEEAALLLAAAAELAALLALLLALAAVEAAALLLAALLLAAVAALLELAALLLLLLAAAEALAALE 600

                        410       420       430
                 ....*....|....*....|....*....|.
gi 806954813 578 SLAGDAEKLRQIVGQFKLDGAMASTSTARTA 608
Cdd:COG2770  601 LELAAAAEAALAEAELLEVAAAAEAGAALLA 631
HAMP pfam00672
HAMP domain;
211-260 1.22e-05

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 43.00  E-value: 1.22e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 806954813  211 ISSWLVTPIRGLVGTMQTLAEGNLSVKVEgTDRRDEVGTMAKAVEVFKDN 260
Cdd:pfam00672   2 LARRILRPLRRLAEAARRIASGDLDVRLP-VSGRDEIGELARAFNQMAER 50
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 216-260 1.29e-05

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 42.43  E-value: 1.29e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 806954813 216 VTPIRGLVGTMQTLAEGNLSVKVEgTDRRDEVGTMAKAVEVFKDN 260
Cdd:cd06225    1 TRPLRRLTEAARRIAEGDLDVRVP-VRSKDEIGELARAFNQMAER 44
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
214-260 9.13e-05

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 40.31  E-value: 9.13e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 806954813   214 WLVTPIRGLVGTMQTLAEGNLSVKVEgTDRRDEVGTMAKAVEVFKDN 260
Cdd:smart00304   2 RLLRPLRRLAEAAQRIADGDLTVRLP-VDGRDEIGELARAFNEMADR 47
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 261-554 3.53e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 3.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 261 ELKARRLEADAAQVRNQSEAERQRTAEIDrRRAAEMAEATSGLAEGLKHMANGDLSYQLKTpfsAEFESLRADFNIAVNQ 340
Cdd:COG1196  221 ELKELEAELLLLKLRELEAELEELEAELE-ELEAELEELEAELAELEAELEELRLELEELE---LELEEAQAEEYELLAE 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 341 LSKTLLSVADVTATIDNGS----------RELSSSASDLSQRTETQAASLEETAAALDQITSNVSNSTRRTEEARIVAVE 410
Cdd:COG1196  297 LARLEQDIARLEERRRELEerleeleeelAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAE 376

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 411 ANRSAQtsgQVVATAVDAMKRIESSSSQISNIIGVIDEIAFQTNLLALNAGVEAARAGEAGKGFAVVAQEVRELAQRSAQ 490
Cdd:COG1196  377 AEEELE---ELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAE 453

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 806954813 491 AAKEIKELIRNSADEVQNGVKLVTATGDALKIIESHVIAINTQLDAIA-TSAREQSVGLAEVNSA 554
Cdd:COG1196  454 LEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEAdYEGFLEGVKAALLLAG 518
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
181-281 3.83e-03

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 40.00  E-value: 3.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 806954813 181 LSDISQRTALITVAAVVLGFITVVVIgyFAISSWLVTPIRGLVGTMQTLAEGNLsVKVEgTDRRDEVGTMAKAVE--VFK 258
Cdd:COG2972  149 FRGLFSLRRLILLIILLLLLLALLLS--YLLSRSITRPIKRLKKAMKKVEKGDL-VRLE-VSGNDEIGILARSFNemVER 224

                         90       100
                 ....*....|....*....|...
gi 806954813 259 DNELKARRLEadaaQVRNQSEAE 281
Cdd:COG2972  225 IKELIEEVYE----LELEKKEAE 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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