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Conserved domains on  [gi|805752158|ref|XP_012140623|]
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PREDICTED: pyruvate kinase-like isoform X2 [Megachile rotundata]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 222-709 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 735.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 222 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSarnglnVPVAIALDTKGPEIRTG 301
Cdd:cd00288    2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRTG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 302 LLEGGgsAEVELQKGQTFKLSTDKAhAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEV-ITTTIENGG 380
Cdd:cd00288   76 LFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 381 MLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLD 460
Cdd:cd00288  153 VLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 461 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 540
Cdd:cd00288  233 EILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 541 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLI 620
Cdd:cd00288  313 SGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLV 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 621 AKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEDAPlADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQGSGF 700
Cdd:cd00288  393 SKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPK-PGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGS 471


                 ....*....
gi 805752158 701 TNTLRVVTV 709
Cdd:cd00288  472 TNTMRILTV 480
Mito_carr pfam00153
Mitochondrial carrier protein;
41-128 3.54e-14

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 68.45  E-value: 3.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158   41 AGFSGAVGGVLGTPGDVINVRMQNDIKLAPELRRNykhALDGIVCIVQQEGFSKLFSGCTTATLRAALMTIGQLSFYDQI 120
Cdd:pfam00153  12 GGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRG---ILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGTYETL 88


                  ....*...
gi 805752158  121 KITMIESG 128
Cdd:pfam00153  89 KRLLLKKL 96
Mito_carr super family cl37969
Mitochondrial carrier protein;
130-190 3.31e-08

Mitochondrial carrier protein;


The actual alignment was detected with superfamily member pfam00153:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 51.50  E-value: 3.31e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805752158  130 FEDNPVTHVLSSVCAGAVATTLTQPLDVLKTRAMNA---KPGEFKSLMDLFLYTAKL-GPLAFFK 190
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQggsGKSKGRGILDCFKKIYKEeGIRGLYK 65
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 222-709 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 735.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 222 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSarnglnVPVAIALDTKGPEIRTG 301
Cdd:cd00288    2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRTG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 302 LLEGGgsAEVELQKGQTFKLSTDKAhAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEV-ITTTIENGG 380
Cdd:cd00288   76 LFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 381 MLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLD 460
Cdd:cd00288  153 VLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 461 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 540
Cdd:cd00288  233 EILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 541 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLI 620
Cdd:cd00288  313 SGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLV 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 621 AKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEDAPlADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQGSGF 700
Cdd:cd00288  393 SKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPK-PGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGS 471


                 ....*....
gi 805752158 701 TNTLRVVTV 709
Cdd:cd00288  472 TNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 222-706 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 659.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  222 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDTKGPEIRTG 301
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKL------GRPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  302 LLEGGgsaEVELQKGQTFKLSTDKAhAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGM 381
Cdd:TIGR01064  75 EIKGG---EVKLKKGDKVIITTDDI-KGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  382 LGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKG-KNIKIISKIENQQGMTNLD 460
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  461 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 540
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  541 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLI 620
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  621 AKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEdaplaDWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTG-WRQGSG 699
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVD-----EEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 805752158  700 FTNTLRV 706
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 226-709 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 649.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 226 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAqknlSARngLNVPVAIALDTKGPEIRTGLLEG 305
Cdd:COG0469    7 IVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREA----AKE--LGRPVAILLDLQGPKIRTGKFKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 306 GGsaeVELQKGQTFKLSTDKahaEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 385
Cdd:COG0469   81 GP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSR 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 386 KGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLDEIIEA 465
Cdd:COG0469  155 KGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 466 SDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGETA 545
Cdd:COG0469  235 SDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 546 KGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKclASAIIVITTTGRSAHLIAKYRP 625
Cdd:COG0469  315 VGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLG--AKAIVAFTESGSTARRISRYRP 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 626 RCPIIAVTRFHQVARQAHLHRGILPLYYEDapladwVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQG-SGFTNTL 704
Cdd:COG0469  393 KVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGTTNTL 466


                 ....*
gi 805752158 705 RVVTV 709
Cdd:COG0469  467 KVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 222-574 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 561.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  222 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSARnglnvpVAIALDTKGPEIRTG 301
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRTG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  302 LLEGGgSAEVELQKGQTFKLSTDKAHAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPE-VITTTIENGG 380
Cdd:pfam00224  76 NTKDG-KKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  381 MLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLD 460
Cdd:pfam00224 155 VIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  461 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 540
Cdd:pfam00224 235 EILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 314

                         330       340       350
                  ....*....|....*....|....*....|....
gi 805752158  541 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIF 574
Cdd:pfam00224 315 SGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 226-693 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 549.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 226 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAqknlSARngLNVPVAIALDTKGPEIRTGLLEG 305
Cdd:PRK05826   8 IVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREI----AAK--LGRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 306 GgsaEVELQKGQTFKLSTDKAhaEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 385
Cdd:PRK05826  82 G---KITLKTGDKFTLDTDQK--EEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 386 KGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKG-KNIKIISKIENQQGMTNLDEIIE 464
Cdd:PRK05826 157 KGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 465 ASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGET 544
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 545 AKGEYPLECVRTMANICKEAEaAIWQIQIFHDLANKALpPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAKYR 624
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAE-KEFSINLSKHRLDRQF-DRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFR 394

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 805752158 625 PRCPIIAVTRFHQVARQAHLHRGILPLYYEDApladwvKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTG 693
Cdd:PRK05826 395 PGAPIFAVTRDEKTQRRLALYRGVYPVLFDSA------ADTDDAAEEALRLLLEKGLVESGDLVVVTSG 457
Mito_carr pfam00153
Mitochondrial carrier protein;
41-128 3.54e-14

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 68.45  E-value: 3.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158   41 AGFSGAVGGVLGTPGDVINVRMQNDIKLAPELRRNykhALDGIVCIVQQEGFSKLFSGCTTATLRAALMTIGQLSFYDQI 120
Cdd:pfam00153  12 GGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRG---ILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGTYETL 88


                  ....*...
gi 805752158  121 KITMIESG 128
Cdd:pfam00153  89 KRLLLKKL 96
Mito_carr pfam00153
Mitochondrial carrier protein;
130-190 3.31e-08

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 51.50  E-value: 3.31e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805752158  130 FEDNPVTHVLSSVCAGAVATTLTQPLDVLKTRAMNA---KPGEFKSLMDLFLYTAKL-GPLAFFK 190
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQggsGKSKGRGILDCFKKIYKEeGIRGLYK 65
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 222-709 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 735.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 222 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSarnglnVPVAIALDTKGPEIRTG 301
Cdd:cd00288    2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRTG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 302 LLEGGgsAEVELQKGQTFKLSTDKAhAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEV-ITTTIENGG 380
Cdd:cd00288   76 LFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 381 MLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLD 460
Cdd:cd00288  153 VLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 461 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 540
Cdd:cd00288  233 EILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 541 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLI 620
Cdd:cd00288  313 SGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLV 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 621 AKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEDAPlADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQGSGF 700
Cdd:cd00288  393 SKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPK-PGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGS 471


                 ....*....
gi 805752158 701 TNTLRVVTV 709
Cdd:cd00288  472 TNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 222-706 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 659.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  222 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDTKGPEIRTG 301
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKL------GRPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  302 LLEGGgsaEVELQKGQTFKLSTDKAhAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGM 381
Cdd:TIGR01064  75 EIKGG---EVKLKKGDKVIITTDDI-KGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  382 LGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKG-KNIKIISKIENQQGMTNLD 460
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  461 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 540
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  541 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLI 620
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  621 AKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEdaplaDWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTG-WRQGSG 699
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVD-----EEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 805752158  700 FTNTLRV 706
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 226-709 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 649.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 226 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAqknlSARngLNVPVAIALDTKGPEIRTGLLEG 305
Cdd:COG0469    7 IVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREA----AKE--LGRPVAILLDLQGPKIRTGKFKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 306 GGsaeVELQKGQTFKLSTDKahaEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 385
Cdd:COG0469   81 GP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSR 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 386 KGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLDEIIEA 465
Cdd:COG0469  155 KGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 466 SDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGETA 545
Cdd:COG0469  235 SDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 546 KGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKclASAIIVITTTGRSAHLIAKYRP 625
Cdd:COG0469  315 VGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLG--AKAIVAFTESGSTARRISRYRP 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 626 RCPIIAVTRFHQVARQAHLHRGILPLYYEDapladwVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQG-SGFTNTL 704
Cdd:COG0469  393 KVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGTTNTL 466


                 ....*
gi 805752158 705 RVVTV 709
Cdd:COG0469  467 KVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 222-574 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 561.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  222 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSARnglnvpVAIALDTKGPEIRTG 301
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRTG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  302 LLEGGgSAEVELQKGQTFKLSTDKAHAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPE-VITTTIENGG 380
Cdd:pfam00224  76 NTKDG-KKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  381 MLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLD 460
Cdd:pfam00224 155 VIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  461 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 540
Cdd:pfam00224 235 EILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 314

                         330       340       350
                  ....*....|....*....|....*....|....
gi 805752158  541 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIF 574
Cdd:pfam00224 315 SGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 226-693 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 549.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 226 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAqknlSARngLNVPVAIALDTKGPEIRTGLLEG 305
Cdd:PRK05826   8 IVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREI----AAK--LGRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 306 GgsaEVELQKGQTFKLSTDKAhaEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 385
Cdd:PRK05826  82 G---KITLKTGDKFTLDTDQK--EEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 386 KGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKG-KNIKIISKIENQQGMTNLDEIIE 464
Cdd:PRK05826 157 KGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 465 ASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGET 544
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 545 AKGEYPLECVRTMANICKEAEaAIWQIQIFHDLANKALpPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAKYR 624
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAE-KEFSINLSKHRLDRQF-DRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFR 394

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 805752158 625 PRCPIIAVTRFHQVARQAHLHRGILPLYYEDApladwvKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTG 693
Cdd:PRK05826 395 PGAPIFAVTRDEKTQRRLALYRGVYPVLFDSA------ADTDDAAEEALRLLLEKGLVESGDLVVVTSG 457
PLN02461 PLN02461
Probable pyruvate kinase
 226-691 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 542.26  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 226 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDTKGPEIRTGLLEG 305
Cdd:PLN02461  25 IVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANT------GILCAVMLDTKGPEIRTGFLKD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 306 GGSaeVELQKGQTFKLSTDKAHaeKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPE--VITTTIENGGMLG 383
Cdd:PLN02461  99 GKP--VQLKQGQEITITTDYSI--KGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEagTVRCRCENSAMLG 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 384 SRKGVNLPGVPVDLPAVSEKDKSD-LQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLDEI 462
Cdd:PLN02461 175 ERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDI 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 463 IEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSG 542
Cdd:PLN02461 255 LAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSG 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 543 ETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAK 622
Cdd:PLN02461 335 ETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAK 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 623 YRPRCPIIAV------TRFHQ-------VARQAHLHRGILPLYYEDAPLADWVKDVDVRVQTGLNFGKSRGFVKTGDSVV 689
Cdd:PLN02461 415 YRPAVPILSVvvpeitTDSFDwscsdeaPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKPGDSVV 494


                 ..
gi 805752158 690 VV 691
Cdd:PLN02461 495 AL 496
PRK09206 PRK09206
pyruvate kinase PykF;
226-706 2.98e-178

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 516.91  E-value: 2.98e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 226 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDTKGPEIRTGLLEG 305
Cdd:PRK09206   6 IVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKT------GKKAAILLDTKGPEIRTMKLEG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 306 GgsAEVELQKGQTFKLSTDKAhaEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 385
Cdd:PRK09206  80 G--NDVSLKAGQTFTFTTDKS--VVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGEN 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 386 KGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGE-KGKNIKIISKIENQQGMTNLDEIIE 464
Cdd:PRK09206 156 KGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAhGGENIQIISKIENQEGLNNFDEILE 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 465 ASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGET 544
Cdd:PRK09206 236 ASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGES 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 545 AKGEYPLECVRTMANICKEAEAAIwQIQIFHDLANKALppvDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAKYR 624
Cdd:PRK09206 316 AKGKYPLEAVSIMATICERTDRVM-NSRLESNNDNRKL---RITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYF 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 625 PRCPIIAVTRFHQVARQAHLHRGILPLyyedapLADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQGSGFTNTL 704
Cdd:PRK09206 392 PDATILALTTNEKTARQLVLSKGVVPQ------LVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGTTNTA 465


                 ..
gi 805752158 705 RV 706
Cdd:PRK09206 466 SV 467
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 248-709 1.14e-177

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 514.60  E-value: 1.14e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 248 MNIARLNFSHGSHEYHAETISNVRQAQKNLsarnGLNVpvAIALDTKGPEIRTGLLEGGGSAeveLQKGQTFKLSTDKAH 327
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAEL----GVNI--AIALDTKGPEIRTGLFVGGEAV---MERGATCYVTTDPAF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 328 AEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPE-VITTTIENGGMLGSRKGVNLPGVPVDLPAVSEKDKS 406
Cdd:PTZ00300  72 ADKGTKDKFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEqTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 407 DLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLDEIIEASDGIMVARGDLGIEIPPEKVF 486
Cdd:PTZ00300 152 DLQFGVEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVV 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 487 LAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGETAKGEYPLECVRTMANICKEAEA 566
Cdd:PTZ00300 232 VAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQS 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 567 AIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAKYRPRCPIIAVTRFHQVARQAHLHR 646
Cdd:PTZ00300 312 AVNEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 391

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 805752158 647 GILPLYYeDAPLADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQGSGFTNTLRVVTV 709
Cdd:PTZ00300 392 GVESVFF-DAERLGHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILV 453
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 226-709 4.46e-172

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 502.76  E-value: 4.46e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 226 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSarnglNVPVAIALDTKGPEIRTGLLEG 305
Cdd:PTZ00066  42 IVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARP-----NANLGILLDTKGPEIRTGFLKN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 306 GgsAEVELQKGQTFKLSTDkaHAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 385
Cdd:PTZ00066 117 H--KPITLKEGQTLKITTD--YTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGER 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 386 KGVNLPGVPVDLPAVSEKDKSD-LQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLDEIIE 464
Cdd:PTZ00066 193 KNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILA 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 465 ASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGET 544
Cdd:PTZ00066 273 ESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGET 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 545 AKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAKYR 624
Cdd:PTZ00066 353 ANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYR 432

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 625 PRCPIIAVTRFHQVARQAHLHRGILplyyedAPLADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQG-SGFTNT 703
Cdd:PTZ00066 433 PSCTILALSASPSVVKSLSVARGVT------TYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEvAGSSNL 506


                 ....*.
gi 805752158 704 LRVVTV 709
Cdd:PTZ00066 507 MKVVKI 512
PRK06354 PRK06354
pyruvate kinase; Provisional
 216-709 8.98e-167

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 491.75  E-value: 8.98e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 216 SRASFVRLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDTKG 295
Cdd:PRK06354   2 SLRDLMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKL------GKTVGILQDLQG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 296 PEIRTGLLEGGGsaeVELQKGQTFKLSTDKAhaeKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEV--IT 373
Cdd:PRK06354  76 PKIRLGRFEDGP---IELKTGDEFILTSREV---LGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLH 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 374 TTIENGGMLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEK-GKNIKIISKIEN 452
Cdd:PRK06354 150 CKVLVGGVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEK 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 453 QQGMTNLDEIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAIL 532
Cdd:PRK06354 230 QEAIDNIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAIL 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 533 DGADCVMLSGETAKGEYPLECVRTMANICKEAEAAIWQIQIF-HDLANKALPPVDATHAVAVAAVEASvkclASAIIVIT 611
Cdd:PRK06354 310 DGTDAVMLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILsKRPEFTTTITNAISQAVSHIALQLD----AAAIVTLT 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 612 TTGRSAHLIAKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEDAPLADWVkdvdvrVQTGLNFGKSRGFVKTGDSVVVV 691
Cdd:PRK06354 386 KSGATARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDET------FDAAINVAQESGLLKQGDLVVIT 459

                        490
                 ....*....|....*....
gi 805752158 692 TGWRQG-SGFTNTLRVVTV 709
Cdd:PRK06354 460 AGTLVGeSGSTDLMKVHVV 478
PRK06247 PRK06247
pyruvate kinase; Provisional
 226-709 1.11e-142

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 425.88  E-value: 1.11e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 226 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDTKGPEIRTGLLEG 305
Cdd:PRK06247   9 ILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDET------GRPIGILADLQGPKLRLGRFAD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 306 GgsaEVELQKGQTFKLSTDKAHaekGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 385
Cdd:PRK06247  83 G---KVQLANGQTFRLDVDDAP---GDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 386 KGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKgknIKIISKIENQQGMTNLDEIIEA 465
Cdd:PRK06247 157 KGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAIDRLEAIVEA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 466 SDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGETA 545
Cdd:PRK06247 234 SDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETA 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 546 KGEYPLECVRTMANICKEAEAAiwqiQIFHDL--ANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAKY 623
Cdd:PRK06247 314 SGKYPVEAVRTMARIIRQVERD----PTYPPLihAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARE 389

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 624 RPRCPIIAVTRFHQVARQAHLHRGIlplyyeDAPLADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQG-SGFTN 702
Cdd:PRK06247 390 RPPLPILALTPNPETARRLALTWGV------HCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGtPGSTN 463


                 ....*..
gi 805752158 703 TLRVVTV 709
Cdd:PRK06247 464 MLRIAYI 470
PLN02765 PLN02765
pyruvate kinase
 215-710 1.48e-117

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 362.83  E-value: 1.48e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 215 ESRASFV-RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDT 293
Cdd:PLN02765  20 PSKPSFFpALTKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNT------KKLCAVMLDT 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 294 KGPEIrtGLLEGGGSAeVELQKGQTFKLSTDKAhaEKGNANLVYVDYDNISKVLKVGNRVFVDDGLIS--------LIVT 365
Cdd:PLN02765  94 VGPEL--QVINKTEKP-ISLKAGNTVTLTPDQS--KEASSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVD 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 366 AVSPEVITTTIENGGML-GSRKGVNLPGVPVDLPAVSEKDKSDL-QFGVEQEVDMIFASFIRNAAALTEIRSILGEKG-K 442
Cdd:PLN02765 169 EVKGDDVVCTVKNSATLaGSLFTLHVSQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlS 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 443 NIKIISKIENQQGMTNLDEIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVIcATQMLESMVKKPRATRA 522
Cdd:PLN02765 249 QTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRA 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 523 ETSDVANAILDGADCVMLSGETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKC 602
Cdd:PLN02765 328 EATDVANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEPMSHLESIASSAVRAAIKV 407

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 603 LASAIIVITTTGRSAHLIAKYRPRCPIIAVT-----------RFH--QVARQAHLHRGILPLyyedapLADWVKDVDVRV 669
Cdd:PLN02765 408 KASVIIVFTSSGRAARLIAKYRPTMPVLSVViprlktnqlkwSFTgaFQARQCLIVRGLFPM------LADPRHSAESTS 481

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 805752158 670 QTG-------LNFGKSRGFVKTGDSVVVVtgwrQGSGFTNTLRVVTVD 710
Cdd:PLN02765 482 ATNesvlkvaLDHGKAAGVIKSHDRVVVC----QKVGDSSVVKIIELD 525
PLN02623 PLN02623
pyruvate kinase
 195-698 2.57e-109

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 343.45  E-value: 2.57e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 195 PNTQALYAQSQLDHMCALDIESRASFVRLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVrqaq 274
Cdd:PLN02623  83 EDNEEVLLEIQQLGETAVGMWSKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLV---- 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 275 KNLSARNGLNVpVAIALDTKGPEIRTGLLegggSAEVELQKGQTFKLSTDKAhaeKGNANLVYVDYDNISKVLKVGNRVF 354
Cdd:PLN02623 159 KEYNAQSKDNV-IAIMLDTKGPEVRSGDL----PQPIMLEEGQEFTFTIKRG---VSTEDCVSVNYDDFVNDVEVGDMLL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 355 VDDGLISLIVTAVSPEVITTTIENGGMLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIR 434
Cdd:PLN02623 231 VDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELK 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 435 SILGEKGKNIKIISKIENQQGMTNLDEIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMV 514
Cdd:PLN02623 311 DYLKSCNADIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMI 390

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 515 KKPRATRAETSDVANAILDGADCVMLSGETAKGEYPLECVRTMANICKEAEAAiwqiqifhdLANKALPPVDATHAVAVA 594
Cdd:PLN02623 391 VHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEAT---------LPEGTTPPNLGQAFKNHM 461

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 595 A------VEASVKCLASAIIVITTTGRSAHLIAKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEdapladWVKDVDVR 668
Cdd:PLN02623 462 SemfafhATMMANTLGTSIIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQ------FSDDAEET 535

                        490       500       510
                 ....*....|....*....|....*....|....*
gi 805752158 669 VQTGLNFGKSRGFVKTGDSVVVVTG-----WRQGS 698
Cdd:PLN02623 536 FARALSLLLNKGMVKEGEEVALVQSgrqpiWRSES 570
PRK06739 PRK06739
pyruvate kinase; Validated
 227-565 2.32e-103

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 319.97  E-value: 2.32e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 227 ICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQaqknlsarngLNVPVAIALDTKGPEIRTGLLEGg 306
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKS----------LDDSIKILGDVQGPKIRLGEIKG- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 307 gsAEVELQKGQTFKLSTDKAhaeKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSRK 386
Cdd:PRK06739  75 --EQITLQAGDSFILHTQPV---TGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHK 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 387 GVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNI-KIISKIENQQGMTNLDEIIEA 465
Cdd:PRK06739 150 GVNLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKE 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 466 SDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGETA 545
Cdd:PRK06739 230 ADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESA 309

                        330       340
                 ....*....|....*....|
gi 805752158 546 KGEYPLECVRTMANICKEAE 565
Cdd:PRK06739 310 SGEHPIESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 221-692 7.36e-91

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 292.80  E-value: 7.36e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 221 VRLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQaqknLSARNGLNVpvAIALDTKGPEIRT 300
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRR----LNEEKGFAV--AVMMDTEGSEIHM 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 301 GLLEGGGSAEVELQKGQTFKL-STDKAHAEKgnanLVYVDYDNISKVLKVGNRVFVDDGLISL-IVTAVSPEVITTTIEN 378
Cdd:PLN02762  98 GDLGGASSAKAEDGEEWTFTVrKFDGSRPEF----TIQVNYDGFAEDVKVGDELVVDGGMVRFeVIEKIGPDVKCKCTDP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 379 GGMLGS------RKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKN--IKIISKI 450
Cdd:PLN02762 174 GLLLPRanltfwRDGSLVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDsdIGVIAKI 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 451 ENQQGMTNLDEIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANA 530
Cdd:PLN02762 254 ESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEA 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 531 ILDGADCVMLSGETAKGEYP---LECVRT----MANICKEA--EAAIWQIQIFHDLANKalppvdATHAVAVAAVEASVK 601
Cdd:PLN02762 334 VRQRADALMLSGESAMGLYPekaLSVLRSvslrMELWSREEkrHEALELPQLSSSLSDR------ISEEICNSAAKMANN 407

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 602 CLASAIIVITTTGRSAHLIAKYRPRCPIIAVTRFHQVARQAHLHRGILPLyyedapLADWVKDVDVRVQTGLNFGKSRGF 681
Cdd:PLN02762 408 LGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPF------RLDFSDDMESNLNKTFSLLKARGM 481

                        490
                 ....*....|.
gi 805752158 682 VKTGDSVVVVT 692
Cdd:PLN02762 482 IKSGDLVIAVS 492
PRK08187 PRK08187
pyruvate kinase; Validated
 243-560 8.29e-50

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 181.75  E-value: 8.29e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 243 MIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSARnglnvpVAIALDTKGPEIRTGLLeGGGSAEVELQKGQTFKLS 322
Cdd:PRK08187 155 LAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRR------CKILMDLAGPKIRTGAV-AGPLGKTRLYTGDRLALV 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 323 TDKAHAEKGNANL-VYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPE----VITTTIENGGMLGSRKGVNLPGVPVDL 397
Cdd:PRK08187 228 AQGPPRRIDEEHFqVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGgallEVTHARPKGLKLKPEKGLNFPDTALDL 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 398 PAVSEKDKSDLQFgVEQEVDMIFASFIRNAAALTEIRSILGEKGKN----IKIISKIENQQGMTNLDEIIEASDG----- 468
Cdd:PRK08187 308 PALTEKDRADLDF-VARHADLVGYSFVQSPGDVEALQAALAARRPDdwrkLGLVLKIETPRAVANLPELIVQAAGrqpfg 386

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 469 IMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAilDGADCVMLSgetaKGE 548
Cdd:PRK08187 387 VMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--ARAECVMLN----KGP 460

                        330
                 ....*....|..
gi 805752158 549 YPLECVRTMANI 560
Cdd:PRK08187 461 YLVEAVTFLDDL 472
PRK14725 PRK14725
pyruvate kinase; Provisional
 240-560 4.97e-40

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 155.88  E-value: 4.97e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 240 LEKMIETGMNIARLNFSHGSHEYHAETISNVRQAqknlSARNGLnvPVAIALDTKGPEIRTGLLEGGG------------ 307
Cdd:PRK14725 158 VRRLLAAGMDIARINCAHDDPEAWRAMIANVRTA----EEELGR--RCRIAMDLAGPKLRTGPIAPGPrviklrptrdal 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 308 ---------------SAEVE-----------------LQKGQTFKLsTDKAHAEK--------GNANLVYVD---Y---- 340
Cdd:PRK14725 232 grvltparlwltaseSPPPSpppgpvglpvdpewlarLEPGDELRF-TDARGKKRkltvtevdDEGVLAEGSqtaYlang 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 341 ----------------------------------------------DNISKV----------LKVGNRVFVDDGLISLIV 364
Cdd:PRK14725 311 tllrlgrhdstrvgglppveqklrlkvgdrlvltrddapgdpaqgdAPPARIsctlpeafraARVGERVWFDDGKIGAVV 390

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 365 TAVSPEVITTTIENGGMLGSR----KGVNLPGVPVDLPAVSEKDKSDLQFgVEQEVDMIFASFIRNAAALTEIRSILGE- 439
Cdd:PRK14725 391 VKVEADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLEDLAF-VAKHADIVALSFVRSPEDVRLLLDALEKl 469

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 440 KGKNIKIISKIENQQGMTNLDEII-EA----SDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMV 514
Cdd:PRK14725 470 GADDLGVVLKIETRRAFENLPRILlEAmrhpRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLA 549

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 805752158 515 KKPRATRAETSDVANAILdgADCVMLSgetaKGEYPLECVRTMANI 560
Cdd:PRK14725 550 KKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDI 589
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
495-710 4.98e-39

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 146.97  E-value: 4.98e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 495 RCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGETAKGEYPLECVRTMANICKEAEAAIwqiqif 574
Cdd:COG3848    1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDL------ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158 575 hdLANKALPPVDATHAVAVAAVEASVKC------LASAIIVITTTGRSAHLIAKYRPRCPIIAVTRFHQVARQAHLHRGI 648
Cdd:COG3848   75 --EYREQRVPRAKESSTTITDAISHAVAttaadlGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGV 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 805752158 649 LPLYYEDAPLADWVKDVDVRVQTGlnfgksRGFVKTGDSVVVVTGWRQG-SGFTNTLRVVTVD 710
Cdd:COG3848  153 YPLLVEESASTDEMFAVAVALALE------AGLVKDGDLVVITAGVPVGvSGTTNLLKVHVVG 209
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 604-707 3.07e-34

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 126.44  E-value: 3.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158  604 ASAIIVITTTGRSAHLIAKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEDApladwvKDVDVRVQTGLNFGKSRGFVK 683
Cdd:pfam02887  16 AKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEA------ETTDEMLRRAVKVAKEAGLVK 89

                          90       100
                  ....*....|....*....|....*
gi 805752158  684 TGDSVVVVTGWRQG-SGFTNTLRVV 707
Cdd:pfam02887  90 KGDLVVITAGVPFGvSGTTNTLKVI 114
Mito_carr pfam00153
Mitochondrial carrier protein;
41-128 3.54e-14

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 68.45  E-value: 3.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752158   41 AGFSGAVGGVLGTPGDVINVRMQNDIKLAPELRRNykhALDGIVCIVQQEGFSKLFSGCTTATLRAALMTIGQLSFYDQI 120
Cdd:pfam00153  12 GGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRG---ILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGTYETL 88


                  ....*...
gi 805752158  121 KITMIESG 128
Cdd:pfam00153  89 KRLLLKKL 96
Mito_carr pfam00153
Mitochondrial carrier protein;
130-190 3.31e-08

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 51.50  E-value: 3.31e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805752158  130 FEDNPVTHVLSSVCAGAVATTLTQPLDVLKTRAMNA---KPGEFKSLMDLFLYTAKL-GPLAFFK 190
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQggsGKSKGRGILDCFKKIYKEeGIRGLYK 65
PRK10558 PRK10558
alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional
 442-503 1.96e-03

alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional


Pssm-ID: 182547  Cd Length: 256  Bit Score: 40.49  E-value: 1.96e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 805752158 442 KNIKIISKIENQQGMTNLDEI--IEASDGIMVARGDL-------GIEIPPEkVFLAQKCMISRCNKVGKPV 503
Cdd:PRK10558 144 KNITVLVQIESQQGVDNVDAIaaTEGVDGIFVGPSDLaaalghlGNASHPD-VQKAIQHIFARAKAHGKPS 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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