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Conserved domains on  [gi|786014178|ref|WP_045724947|]
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MULTISPECIES: penicillin-binding protein 2 [Clostridium]

Protein Classification

peptidoglycan D,D-transpeptidase FtsI family protein( domain architecture ID 11433609)

peptidoglycan D,D-transpeptidase FtsI (penicillin-binding protein (PBP) 2) family protein is a membrane-associated enzyme that is most likely involved in the synthesis of cross-linked peptidoglycan

EC:  3.4.16.4
Gene Ontology:  GO:0009002|GO:0071555|GO:0016787|GO:0009252|GO:0008658|GO:0016020|GO:0051301|GO:0005886|GO:0008955
PubMed:  32762868|32442851|18266856|18248419

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 1-489 2.22e-111

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 341.03  E-value: 2.22e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178   1 MKDDIKKSVTK-----VMMVFLFCLIALITYIAYFQAFKAPDIAAKPGNQRawaVRNRVL---RGTIYDRNNNVIAKSV- 71
Cdd:COG0768    1 MKRKKEKRLFRrrlllLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENR---IRTVPIpapRGLIYDRNGNVLATNVp 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  72 ------------------------------------REKNN-----------------------------VQKRVYPDGA 86
Cdd:COG0768   78 vyslyadpeevkdpeetaeklakllgldpeelrkklKKKSRfpvylkrnlspeeaariralklpgvyveaEYKRYYPYGE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  87 VFAAPIGFMDS-----RFGGSGLEAAYDKQLTTTsnmtASFKKLIDDPS---IANLKEaffdrkDDKDRQGNSVVTTLDS 158
Cdd:COG0768  158 LAAHVLGYVGEinggdGIGKSGLEKAYEDLLRGT----PGKRRVEVDARgrvIRDLGE------EKPPVPGKDLVLTIDS 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 159 KLQKVAYNALGN-------DRGAVVALDPKTGNVLAMVSKPTYNPNNLAeemkkansgDLEHSILLNRAIQGQYPPGSTF 231
Cdd:COG0768  228 DLQKIAEEALKKaveeykaKSGAVVVMDPKTGEILAMASYPSFDPNLFV---------GGPDEPLRNRAVQGTYEPGSTF 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 232 KVVTTASALDNipGV--QNKTFTDNGVLKFegGGKELHNSGDASYGSLDLKKAFVVSSNVVYGTLAMDLGNDKLMKTAER 309
Cdd:COG0768  299 KPFTAAAALEE--GVitPDTTFDCPGYYRV--GGRTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLYDYLKK 374

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 310 FGFNEQ----IP--ANGFTIGKSTFpkltYSGDIARSGIGQStIIVNPMQMALVASAVANNGVIMQPNLVSKVVDKDGTT 383
Cdd:COG0768  375 FGLGQKtgidLPgeASGLLPSPKRW----YPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEV 449

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 384 IEvEKPKEYQRAMSEDDAATIKSYMKALVDKNIQSGTWSYL------------QGTGTAGKTGTADHNLpngqpapphSW 451
Cdd:COG0768  450 VK-EEPEVLRRVISPETAETVREGMEGVVNEPGGTARRAAIpgyrvagktgtaQVVDIGNGGYYKGRHI---------AS 519

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|.
gi 786014178 452 FICFAPADNPKIAVAVVVEDGG---YGAKKAASVAGKVINA 489
Cdd:COG0768  520 FVGFAPADNPRYAVAVVVENPGggaYGGTVAAPVFREIMEA 560
 
Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 1-489 2.22e-111

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 341.03  E-value: 2.22e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178   1 MKDDIKKSVTK-----VMMVFLFCLIALITYIAYFQAFKAPDIAAKPGNQRawaVRNRVL---RGTIYDRNNNVIAKSV- 71
Cdd:COG0768    1 MKRKKEKRLFRrrlllLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENR---IRTVPIpapRGLIYDRNGNVLATNVp 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  72 ------------------------------------REKNN-----------------------------VQKRVYPDGA 86
Cdd:COG0768   78 vyslyadpeevkdpeetaeklakllgldpeelrkklKKKSRfpvylkrnlspeeaariralklpgvyveaEYKRYYPYGE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  87 VFAAPIGFMDS-----RFGGSGLEAAYDKQLTTTsnmtASFKKLIDDPS---IANLKEaffdrkDDKDRQGNSVVTTLDS 158
Cdd:COG0768  158 LAAHVLGYVGEinggdGIGKSGLEKAYEDLLRGT----PGKRRVEVDARgrvIRDLGE------EKPPVPGKDLVLTIDS 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 159 KLQKVAYNALGN-------DRGAVVALDPKTGNVLAMVSKPTYNPNNLAeemkkansgDLEHSILLNRAIQGQYPPGSTF 231
Cdd:COG0768  228 DLQKIAEEALKKaveeykaKSGAVVVMDPKTGEILAMASYPSFDPNLFV---------GGPDEPLRNRAVQGTYEPGSTF 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 232 KVVTTASALDNipGV--QNKTFTDNGVLKFegGGKELHNSGDASYGSLDLKKAFVVSSNVVYGTLAMDLGNDKLMKTAER 309
Cdd:COG0768  299 KPFTAAAALEE--GVitPDTTFDCPGYYRV--GGRTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLYDYLKK 374

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 310 FGFNEQ----IP--ANGFTIGKSTFpkltYSGDIARSGIGQStIIVNPMQMALVASAVANNGVIMQPNLVSKVVDKDGTT 383
Cdd:COG0768  375 FGLGQKtgidLPgeASGLLPSPKRW----YPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEV 449

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 384 IEvEKPKEYQRAMSEDDAATIKSYMKALVDKNIQSGTWSYL------------QGTGTAGKTGTADHNLpngqpapphSW 451
Cdd:COG0768  450 VK-EEPEVLRRVISPETAETVREGMEGVVNEPGGTARRAAIpgyrvagktgtaQVVDIGNGGYYKGRHI---------AS 519

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|.
gi 786014178 452 FICFAPADNPKIAVAVVVEDGG---YGAKKAASVAGKVINA 489
Cdd:COG0768  520 FVGFAPADNPRYAVAVVVENPGggaYGGTVAAPVFREIMEA 560
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 12-493 5.47e-93

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 294.05  E-value: 5.47e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178   12 VMMVFLFCLIALITYiaYFQAFKAPDIAAKPGNQRawaVRNRVL---RGTIYDRNNNVIA-------------------- 68
Cdd:TIGR03423   8 GLVLALFGVLAARLF--YLQVIRGEEYATLSEDNR---IRLVPIpppRGLILDRNGVLLAdnrpsfsleivpekvddlda 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178   69 -----------------------------KSVREKNNV-----------------------QKRVYPDGAVFAAPIGFM- 95
Cdd:TIGR03423  83 tldrlaklldldpediarflkelkrsrrfEPIPLKSDLteeevarfavnqyrlpgveiearLKRYYPYGELAAHVLGYVg 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178   96 -----------------DSRFGGSGLEAAYDKQL--------TTTSNMTASFKKLIDDPSIAnlkeaffdrkddkdrqGN 150
Cdd:TIGR03423 163 eineedlerlepanyagGDYIGKSGIEKYYEDELrgkpgyreVEVNARGRVIRTLSRVPPVP----------------GK 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  151 SVVTTLDSKLQKVAYNALGNDRGAVVALDPKTGNVLAMVSKPTYNPNNLAEEMKKANSGDL---EHSILLNRAIQGQYPP 227
Cdd:TIGR03423 227 DLVLTIDARLQQAAEKALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALlndPDRPLLNRAIQGVYPP 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  228 GSTFKVVTTASALDNipGV--QNKTFTDNGVLKFegGGKELHNSGDASYGSLDLKKAFVVSSNVVYGTLAMDLGNDKLMK 305
Cdd:TIGR03423 307 GSTFKPVVALAALEE--GVitPETRIYCPGYFQL--GGRRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAE 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  306 TAERFGFNEQ--IPANGFTIG--------KSTFPKLTYSGDIARSGIGQSTIIVNPMQMALVASAVANNGVIMQPNLVSK 375
Cdd:TIGR03423 383 YAKRFGFGQKtgIDLPGEKSGlvpsrewkRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVKS 462

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  376 VVDKDGTTIEVEKPKEYQRA-MSEDDAATIKSYMKALVdkNIQSGTWSYL---------------QGTGTAGKTGTADHN 439
Cdd:TIGR03423 463 IEDPDGGVVRRTEPEVLRPLpISPENLDVVREGMRDVV--NGPGGTARRArlglpykmagktgtaQVVSLKQGEKYDAEQ 540

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 786014178  440 LP-NGQpapPHSWFICFAPADNPKIAVAVVVEDGGYGAKKAASVAGKVINAELNK 493
Cdd:TIGR03423 541 IPeRLR---DHALFVAFAPYDNPKIAVAVIVEHGGGGSSAAAPIARKIMDAYLLG 592
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 173-487 3.33e-48

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 167.98  E-value: 3.33e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  173 GAVVALDPKTGNVLAMVSKPTYNPNNLAeemkkansgdlehSILLNRAIQGQYPPGSTFKVVTTASALDNipGV--QNKT 250
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFI-------------GPLRNRAVTSRYEPGSTFKPFTALAALDN--GVlkPDET 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  251 FTDNGVLKFEGGGKELHNSGDASYGslDLKKAFVVSSNVVYGTLAMDLGNDKLMKTAERFGFNEQIPAN--GFTIGKSTF 328
Cdd:pfam00905  66 IFDWPGKQQGGKSIGDWNQDQVGIG--TLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGlpGENAGYLTP 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  329 PKLtySGDIARSGIGqstIIVNPMQMALVASAVANNGVIMQPNLVSKVVDKDGTTIEVEKPkeyqraMSEDDAATIKSYM 408
Cdd:pfam00905 144 YWL--EGATASFGIG---LTITPLQQAQAYAAIANGGKLVPPHLVKSIEDKVDPKVLNKLP------ISKSTAEKVKDML 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  409 KALVDKNIQSGTWSYL-----------QGTGTAGKTGTADHNlpngqpappHSWFICFAPADNPKIAVAVVVEDGG--YG 475
Cdd:pfam00905 213 RLVVNDGTGTGTAAVPgykvagktgtaQVAGPKGGGYYDGAQ---------IGWFVGYAPADNPKYAFAVLIDDPKryYG 283

                         330
                  ....*....|..
gi 786014178  476 AKKAASVAGKVI 487
Cdd:pfam00905 284 GKVAAPIFKDIL 295
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 149-475 1.92e-34

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 136.82  E-value: 1.92e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 149 GNSVVTTLDSKLQKVAYNALGNDRGAVVALDPKTGNVLAMVSKPTYNPNNLAEEMKKANSGDL---EHSILLNRAIQGQY 225
Cdd:PRK10795 248 GHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGILALVSTPSYDPNLFVDGISSKDYSGLlndPNRPLINRATQGVY 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 226 PPGSTFKVVTTASALDniPGVQNKTFT--DNGVLKFEGGGKELHNSGDASYGSLDLKKAFVVSSNVVYGTLAMDLGNDKL 303
Cdd:PRK10795 328 PPASTVKPYVAVSALS--AGVITRNTSlfDPGWWQLPGSEKRYRDWKKWGHGRLNVTKSLEESADTFFYQVAYDMGIDRL 405

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 304 MKTAERFGFNEQ------------IPANGFTIGKstFPKLTYSGDIARSGIGQSTIIVNPMQMALVASAVANNGVIMQPN 371
Cdd:PRK10795 406 SEWMGKFGYGHYtgidlaeersgnMPTREWKQKR--FKKPWYQGDTIPVGIGQGYWTATPIQMSKALMTLINDGIVKVPH 483

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 372 LVSKVVDkDGTTIEVEKPKEYQRAmseddaatiksymkalvdkNIQSGTWSYLQGTGTAGKtgtadhNLPNGQP------ 445
Cdd:PRK10795 484 LLMSTAE-DGKQVPWVQPHEPPVG-------------------DIHSGYWEIAKDGMYGVA------NRPNGTAhkyfas 537

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 786014178 446 AP-------------------------------PHSWFICFAPADNPKIAVAVVVEDGGYG 475
Cdd:PRK10795 538 APykiaaksgtaqvfglkanetynahkiaerlrDHKLMTAFAPYNNPQVAVAIILENGGAG 598
 
Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 1-489 2.22e-111

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 341.03  E-value: 2.22e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178   1 MKDDIKKSVTK-----VMMVFLFCLIALITYIAYFQAFKAPDIAAKPGNQRawaVRNRVL---RGTIYDRNNNVIAKSV- 71
Cdd:COG0768    1 MKRKKEKRLFRrrlllLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENR---IRTVPIpapRGLIYDRNGNVLATNVp 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  72 ------------------------------------REKNN-----------------------------VQKRVYPDGA 86
Cdd:COG0768   78 vyslyadpeevkdpeetaeklakllgldpeelrkklKKKSRfpvylkrnlspeeaariralklpgvyveaEYKRYYPYGE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  87 VFAAPIGFMDS-----RFGGSGLEAAYDKQLTTTsnmtASFKKLIDDPS---IANLKEaffdrkDDKDRQGNSVVTTLDS 158
Cdd:COG0768  158 LAAHVLGYVGEinggdGIGKSGLEKAYEDLLRGT----PGKRRVEVDARgrvIRDLGE------EKPPVPGKDLVLTIDS 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 159 KLQKVAYNALGN-------DRGAVVALDPKTGNVLAMVSKPTYNPNNLAeemkkansgDLEHSILLNRAIQGQYPPGSTF 231
Cdd:COG0768  228 DLQKIAEEALKKaveeykaKSGAVVVMDPKTGEILAMASYPSFDPNLFV---------GGPDEPLRNRAVQGTYEPGSTF 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 232 KVVTTASALDNipGV--QNKTFTDNGVLKFegGGKELHNSGDASYGSLDLKKAFVVSSNVVYGTLAMDLGNDKLMKTAER 309
Cdd:COG0768  299 KPFTAAAALEE--GVitPDTTFDCPGYYRV--GGRTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLYDYLKK 374

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 310 FGFNEQ----IP--ANGFTIGKSTFpkltYSGDIARSGIGQStIIVNPMQMALVASAVANNGVIMQPNLVSKVVDKDGTT 383
Cdd:COG0768  375 FGLGQKtgidLPgeASGLLPSPKRW----YPGETATMSIGQG-LSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEV 449

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 384 IEvEKPKEYQRAMSEDDAATIKSYMKALVDKNIQSGTWSYL------------QGTGTAGKTGTADHNLpngqpapphSW 451
Cdd:COG0768  450 VK-EEPEVLRRVISPETAETVREGMEGVVNEPGGTARRAAIpgyrvagktgtaQVVDIGNGGYYKGRHI---------AS 519

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|.
gi 786014178 452 FICFAPADNPKIAVAVVVEDGG---YGAKKAASVAGKVINA 489
Cdd:COG0768  520 FVGFAPADNPRYAVAVVVENPGggaYGGTVAAPVFREIMEA 560
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 12-493 5.47e-93

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 294.05  E-value: 5.47e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178   12 VMMVFLFCLIALITYiaYFQAFKAPDIAAKPGNQRawaVRNRVL---RGTIYDRNNNVIA-------------------- 68
Cdd:TIGR03423   8 GLVLALFGVLAARLF--YLQVIRGEEYATLSEDNR---IRLVPIpppRGLILDRNGVLLAdnrpsfsleivpekvddlda 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178   69 -----------------------------KSVREKNNV-----------------------QKRVYPDGAVFAAPIGFM- 95
Cdd:TIGR03423  83 tldrlaklldldpediarflkelkrsrrfEPIPLKSDLteeevarfavnqyrlpgveiearLKRYYPYGELAAHVLGYVg 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178   96 -----------------DSRFGGSGLEAAYDKQL--------TTTSNMTASFKKLIDDPSIAnlkeaffdrkddkdrqGN 150
Cdd:TIGR03423 163 eineedlerlepanyagGDYIGKSGIEKYYEDELrgkpgyreVEVNARGRVIRTLSRVPPVP----------------GK 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  151 SVVTTLDSKLQKVAYNALGNDRGAVVALDPKTGNVLAMVSKPTYNPNNLAEEMKKANSGDL---EHSILLNRAIQGQYPP 227
Cdd:TIGR03423 227 DLVLTIDARLQQAAEKALGGRRGAVVVMDPRTGEILAMVSTPSFDPNLFVDGISSKDYKALlndPDRPLLNRAIQGVYPP 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  228 GSTFKVVTTASALDNipGV--QNKTFTDNGVLKFegGGKELHNSGDASYGSLDLKKAFVVSSNVVYGTLAMDLGNDKLMK 305
Cdd:TIGR03423 307 GSTFKPVVALAALEE--GVitPETRIYCPGYFQL--GGRRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAE 382

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  306 TAERFGFNEQ--IPANGFTIG--------KSTFPKLTYSGDIARSGIGQSTIIVNPMQMALVASAVANNGVIMQPNLVSK 375
Cdd:TIGR03423 383 YAKRFGFGQKtgIDLPGEKSGlvpsrewkRKRFGQPWYPGDTLNVSIGQGYVLVTPLQLAVATAALANGGKLYKPHLVKS 462

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  376 VVDKDGTTIEVEKPKEYQRA-MSEDDAATIKSYMKALVdkNIQSGTWSYL---------------QGTGTAGKTGTADHN 439
Cdd:TIGR03423 463 IEDPDGGVVRRTEPEVLRPLpISPENLDVVREGMRDVV--NGPGGTARRArlglpykmagktgtaQVVSLKQGEKYDAEQ 540

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 786014178  440 LP-NGQpapPHSWFICFAPADNPKIAVAVVVEDGGYGAKKAASVAGKVINAELNK 493
Cdd:TIGR03423 541 IPeRLR---DHALFVAFAPYDNPKIAVAVIVEHGGGGSSAAAPIARKIMDAYLLG 592
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 173-487 3.33e-48

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 167.98  E-value: 3.33e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  173 GAVVALDPKTGNVLAMVSKPTYNPNNLAeemkkansgdlehSILLNRAIQGQYPPGSTFKVVTTASALDNipGV--QNKT 250
Cdd:pfam00905   1 GSAVVLDPKTGEVLAMVGKPSYDPNGFI-------------GPLRNRAVTSRYEPGSTFKPFTALAALDN--GVlkPDET 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  251 FTDNGVLKFEGGGKELHNSGDASYGslDLKKAFVVSSNVVYGTLAMDLGNDKLMKTAERFGFNEQIPAN--GFTIGKSTF 328
Cdd:pfam00905  66 IFDWPGKQQGGKSIGDWNQDQVGIG--TLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGlpGENAGYLTP 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  329 PKLtySGDIARSGIGqstIIVNPMQMALVASAVANNGVIMQPNLVSKVVDKDGTTIEVEKPkeyqraMSEDDAATIKSYM 408
Cdd:pfam00905 144 YWL--EGATASFGIG---LTITPLQQAQAYAAIANGGKLVPPHLVKSIEDKVDPKVLNKLP------ISKSTAEKVKDML 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  409 KALVDKNIQSGTWSYL-----------QGTGTAGKTGTADHNlpngqpappHSWFICFAPADNPKIAVAVVVEDGG--YG 475
Cdd:pfam00905 213 RLVVNDGTGTGTAAVPgykvagktgtaQVAGPKGGGYYDGAQ---------IGWFVGYAPADNPKYAFAVLIDDPKryYG 283

                         330
                  ....*....|..
gi 786014178  476 AKKAASVAGKVI 487
Cdd:pfam00905 284 GKVAAPIFKDIL 295
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 134-420 1.42e-46

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 171.26  E-value: 1.42e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 134 LKEAFfdRKDDKDRQGNSVVTTLDSKLQKVAYNAL---------GNDRGAVVALDPKTGNVLAMVSKPTYNPNNLaeemk 204
Cdd:COG0744  281 LEELL--GEDDLYRGGLKIYTTLDPKLQKAAEKAVknvlpegkpGGLQAALVVVDPKTGEVLAMVGGRDYGKSQF----- 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 205 kansgdlehsillNRAIQGQYPPGSTFKVVTTASALDNipGVQNKTFTDNGVLKFEGGGKELHNSGDASYGSLDLKKAFV 284
Cdd:COG0744  354 -------------NRATQAKRQPGSTFKPFVYAAALEQ--GYTPATTVDDEPVTFPGGGWSPKNYDGRYRGPVTLREALA 418

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 285 VSSNVVYGTLAMDLGNDKLMKTAERFGFNEQIPAN-GFTIGKSTfpkltysgdiarsgigqstiiVNPMQMALVASAVAN 363
Cdd:COG0744  419 NSLNTPAVRLAQEVGLDKVVDTARRLGITSPLDPNpSLALGTSE---------------------VSPLEMASAYATFAN 477

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 786014178 364 NGVIMQPNLVSKVVDKDGTTIEVEKPKEyQRAMSEDDAATIKSYMKalvdKNIQSGT 420
Cdd:COG0744  478 GGVYVEPHAITKVTDADGKVLYEAKPKC-EQVISPEVAYLMTDMLQ----DVVTSGT 529
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 149-475 1.92e-34

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 136.82  E-value: 1.92e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 149 GNSVVTTLDSKLQKVAYNALGNDRGAVVALDPKTGNVLAMVSKPTYNPNNLAEEMKKANSGDL---EHSILLNRAIQGQY 225
Cdd:PRK10795 248 GHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGILALVSTPSYDPNLFVDGISSKDYSGLlndPNRPLINRATQGVY 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 226 PPGSTFKVVTTASALDniPGVQNKTFT--DNGVLKFEGGGKELHNSGDASYGSLDLKKAFVVSSNVVYGTLAMDLGNDKL 303
Cdd:PRK10795 328 PPASTVKPYVAVSALS--AGVITRNTSlfDPGWWQLPGSEKRYRDWKKWGHGRLNVTKSLEESADTFFYQVAYDMGIDRL 405

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 304 MKTAERFGFNEQ------------IPANGFTIGKstFPKLTYSGDIARSGIGQSTIIVNPMQMALVASAVANNGVIMQPN 371
Cdd:PRK10795 406 SEWMGKFGYGHYtgidlaeersgnMPTREWKQKR--FKKPWYQGDTIPVGIGQGYWTATPIQMSKALMTLINDGIVKVPH 483

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 372 LVSKVVDkDGTTIEVEKPKEYQRAmseddaatiksymkalvdkNIQSGTWSYLQGTGTAGKtgtadhNLPNGQP------ 445
Cdd:PRK10795 484 LLMSTAE-DGKQVPWVQPHEPPVG-------------------DIHSGYWEIAKDGMYGVA------NRPNGTAhkyfas 537

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 786014178 446 AP-------------------------------PHSWFICFAPADNPKIAVAVVVEDGGYG 475
Cdd:PRK10795 538 APykiaaksgtaqvfglkanetynahkiaerlrDHKLMTAFAPYNNPQVAVAIILENGGAG 598
PBP_1a_fam TIGR02074
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
 147-420 2.44e-30

penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273955 [Multi-domain]  Cd Length: 531  Bit Score: 123.91  E-value: 2.44e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  147 RQGNSVVTTLDSKLQKVAYNALGND------------RGAVVALDPKTGNVLAMVSKPTYNPNNLaeemkkansgdlehs 214
Cdd:TIGR02074 219 TGGLKIYTTLDLDAQKAAEKVLNTGlrvagrrdgddlQAALVAIDPDTGAVRALVGGRDYGKSQF--------------- 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  215 illNRAIQGQYPPGSTFKVVTTASALDNipGV-QNKTFTDNGVlKFEGGGK-ELHNSGDASYGSLDLKKAFVVSSNVVYG 292
Cdd:TIGR02074 284 ---NRATQAKRQPGSTFKPFVYAAALEK--GLtPATIVNDEPI-TYNGNGPwSPKNYGGGYRGNVTLRQALAQSRNIPAV 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  293 TLAMDLGNDKLMKTAERFGFNEQIPangftigkstfpkLTYSgdiarsgIGQSTIIVNPMQMALVASAVANNGVIMQPNL 372
Cdd:TIGR02074 358 RLLQEVGLDKVVALAKRFGITSPLD-------------PVLS-------LALGTVEVSPLEMASAYAVFANGGKYVEPHG 417

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 786014178  373 VSKVVDKDGTTIEVEKPKEYQrAMSEDDAATIKSYMKALVdkniQSGT 420
Cdd:TIGR02074 418 IRKIVDRDGKVIYENKPKTTQ-VISPATAYIMTDMLKGVV----ESGT 460
PRK15105 PRK15105
peptidoglycan synthase FtsI; Provisional
 79-491 8.66e-28

peptidoglycan synthase FtsI; Provisional


Pssm-ID: 185060 [Multi-domain]  Cd Length: 578  Bit Score: 116.84  E-value: 8.66e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178  79 KRVYPDGAVFAAPIGF--MDSRfGGSGLEAAYDKQLTTTSNMTA----SFKKLIDDPSIANLKEAffdrkddkdrqgNSV 152
Cdd:PRK15105 165 RRYYPSGEVTAHLIGFtnVDSQ-GIEGVEKSFDKWLTGQPGERIvrkdRYGRVIEDISSTDSQAA------------HNL 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 153 VTTLDSKLQKVAYNALGN-------DRGAVVALDPKTGNVLAMVSKPTYNPNNLAEEMKKAnsgdlehsiLLNRAIQGQY 225
Cdd:PRK15105 232 ALSIDERLQALVYRELNNavafnkaESGSAVLVDVNTGEVLAMANSPSYNPNNLSGTPKDA---------MRNRAITDVF 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 226 PPGSTFKVVTTASALdnipgvQNKTFTDNGVLK---FEGGGKELHNSgdASYGSLDLKKAFVVSSNVVYGTLAMDLGNDK 302
Cdd:PRK15105 303 EPGSTVKPMVVMTAL------QRGVVKENSVLNtvpYRINGHEIKDV--ARYSELTLTGVLQKSSNVGVSKLALAMPSSA 374

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 303 LMKTAERFGFNEqiPANGFTIGKST--FPKLTYSGDIARS----GIGqstIIVNPMQMALVASAVANNGvIMQPNLVSKv 376
Cdd:PRK15105 375 LVDTYSRFGLGK--ATNLGLVGERSglYPQKQRWSDIERAtfsfGYG---LMVTPLQLARVYATIGSYG-IYRPLSITK- 447

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 377 VDKD--GTTIEVEKPKEYQRAMSEDDA--------ATIKSYMKAlvdknIQSGTWSYLQgtgtagktgtadhnlPNGQPA 446
Cdd:PRK15105 448 VDPPvpGERVFPESIVRTVVHMMESVAlpggggvkAAIKGYRIA-----IKTGTAKKVG---------------PDGRYI 507

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 786014178 447 PPH-SWFICFAPADNPKIAVAVVVED--GG--YGAKKAASVAGKVINAEL 491
Cdd:PRK15105 508 NKYiAYTAGVAPASQPRFALVVVINDpqAGkyYGGAVSAPVFGAIMGGVL 557
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
173-480 5.34e-17

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 84.06  E-value: 5.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 173 GAVVALDPKTGNVLAMVskptynpnnlaeemkkansG--DLEHSILlNRAIQGQYPPGSTFKVVTTASALDNipGvqnkt 250
Cdd:COG5009  423 GALVALDPHTGAVLALV-------------------GgfDFEQSKF-NRATQAKRQPGSSFKPFVYAAALDN--G----- 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 251 FT------DNGVLKFEGGGKEL---HNSGDASYGSLDLKKAFVVSSNVVYGTLAMDLGNDKLMKTAERFGFNEQIPANgf 321
Cdd:COG5009  476 YTpatiinDAPIVFDDGGGGGVwrpKNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYVIDYAERFGIYSKLPPN-- 553

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 322 tigkstfpkLTYSgdiarsgIGQSTiiVNPMQMALVASAVANNGVIMQPNLVSKVVDKDGTTIEVEKPK----------- 390
Cdd:COG5009  554 ---------LSLA-------LGSGE--VTPLEMARAYAVFANGGYRVEPYLIDRIEDRNGKVIYRADPAracedcdaaew 615

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 391 ---------EYQRAMSEDDAATIKSYMKAlvdkNIQSGTWSYLQGTGTAGK--T----GTADhnlpngqpapphSWFICF 455
Cdd:COG5009  616 dgaeprlpdPAEQVIDPRTAYQMTSMLRG----VVQRGTGRRARALGRDIAgkTgttnDSKD------------AWFVGF 679

                        330       340       350
                 ....*....|....*....|....*....|...
gi 786014178 456 apadNPKIAVAVVV--------EDGGYGAKKAA 480
Cdd:COG5009  680 ----TPDLVAGVWVgfddprslGRGETGGRAAL 708
mrcA PRK11636
penicillin-binding protein 1a; Provisional
 174-390 2.12e-05

penicillin-binding protein 1a; Provisional


Pssm-ID: 183248 [Multi-domain]  Cd Length: 850  Bit Score: 47.05  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 174 AVVALDPKTGNVLAMVSKPTYNPNNLaeemkkansgdlehsillNRAIQGQYPPGSTFKVVTTASALDNipGVQNKT-FT 252
Cdd:PRK11636 428 ALVSINPQNGAVMALVGGFDFNQSKF------------------NRATQALRQVGSNIKPFLYTAAMDK--GLTLASmLN 487

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 786014178 253 DNGVLKFE-GGGKELH--NSGDASYGSLDLKKAFVVSSNVVYGTLAMDLGNDKLMKTAERFGFNEQ--IPANGFTIGKST 327
Cdd:PRK11636 488 DVPISRWDaGAGSDWRpkNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDYAAEYLQRFGFPAQniVHTESLALGSAS 567

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 786014178 328 FpkltysgdiarsgigqstiivNPMQMALVASAVANNGVIMQPNLVSKVVDKDGTTIEVEKPK 390
Cdd:PRK11636 568 F---------------------TPMQVARGYAVMANGGFLVDPYFISKIENDQGGVIFEAKPK 609
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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