NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|782909580|gb|AJZ72667|]
View 

VP2 [Thetapolyomavirus trepennellii]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Lebercilin super family cl25726
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 277-363 8.58e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


The actual alignment was detected with superfamily member pfam15619:

Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 37.57  E-value: 8.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782909580  277 QDKWLKDIEKEEGKAKERERRLENQLRHLTEEHRRKSRAHRLLDERewenddrlAKKLEKDLQKVKDDNDKREQFLEDAV 356
Cdd:pfam15619  44 QEKALGKYEGTESELPQLIARHNEEVRVLRERLRRLQEKERDLERK--------LKEKEAELLRLRDQLKRLEKLSEDKN 115


                  ....*..
gi 782909580  357 HYRREDL 363
Cdd:pfam15619 116 LAEREEL 122
 
Name Accession Description Interval E-value
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 277-363 8.58e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 37.57  E-value: 8.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782909580  277 QDKWLKDIEKEEGKAKERERRLENQLRHLTEEHRRKSRAHRLLDERewenddrlAKKLEKDLQKVKDDNDKREQFLEDAV 356
Cdd:pfam15619  44 QEKALGKYEGTESELPQLIARHNEEVRVLRERLRRLQEKERDLERK--------LKEKEAELLRLRDQLKRLEKLSEDKN 115


                  ....*..
gi 782909580  357 HYRREDL 363
Cdd:pfam15619 116 LAEREEL 122
 
Name Accession Description Interval E-value
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 277-363 8.58e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 37.57  E-value: 8.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 782909580  277 QDKWLKDIEKEEGKAKERERRLENQLRHLTEEHRRKSRAHRLLDERewenddrlAKKLEKDLQKVKDDNDKREQFLEDAV 356
Cdd:pfam15619  44 QEKALGKYEGTESELPQLIARHNEEVRVLRERLRRLQEKERDLERK--------LKEKEAELLRLRDQLKRLEKLSEDKN 115


                  ....*..
gi 782909580  357 HYRREDL 363
Cdd:pfam15619 116 LAEREEL 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH