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Conserved domains on  [gi|77415462|gb|AAI06112|]
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Igfals protein, partial [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-300 1.14e-20

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 1.14e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  93 AFQNLSSLDFLNLQGSWLRSLePQALLGLQNLYHLHLERNLLRSLAAGLFRHTpSLASLSLGNNLLGRLEEGLFrGLSHL 172
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTDLPEELG-NLTNL 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 173 WDLNLGWNSLVVLPDTvFQGLGNLHELVLAGNKLTYLqPALLCGLGELRELDLSRNALRSVKAnvFIHLPRLQKLYLDRN 252
Cdd:COG4886 185 KELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 77415462 253 LITAVAPRAFLgmKALRWLDLSHNRVAGLLEDTFPGLLGLHVLRLAHN 300
Cdd:COG4886 261 QLTDLPPLANL--TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRRNT smart00013
Leucine rich repeat N-terminal domain;
40-78 1.14e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.23  E-value: 1.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 77415462     40 QCPVTCTCSyddytdELSVFCSSRNLTQLPDGIPVSTRA 78
Cdd:smart00013   1 ACPAPCNCS------GTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-300 1.14e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 1.14e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  93 AFQNLSSLDFLNLQGSWLRSLePQALLGLQNLYHLHLERNLLRSLAAGLFRHTpSLASLSLGNNLLGRLEEGLFrGLSHL 172
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTDLPEELG-NLTNL 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 173 WDLNLGWNSLVVLPDTvFQGLGNLHELVLAGNKLTYLqPALLCGLGELRELDLSRNALRSVKAnvFIHLPRLQKLYLDRN 252
Cdd:COG4886 185 KELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 77415462 253 LITAVAPRAFLgmKALRWLDLSHNRVAGLLEDTFPGLLGLHVLRLAHN 300
Cdd:COG4886 261 QLTDLPPLANL--TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
55-291 1.88e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.41  E-value: 1.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462   55 ELSVfcSSRNLTQLPDGIPVSTRALWLDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQallGLQnlyHLHLERNLL 134
Cdd:PRK15370 224 TLYA--NSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPE---ELR---YLSVYDNSI 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  135 RSLAAglfrHTPSlaslslgnnllgrleeglfrGLSHLWDLNlgwNSLVVLPDTVFQGLgnlhELVLAG-NKLTYLQPAL 213
Cdd:PRK15370 296 RTLPA----HLPS--------------------GITHLNVQS---NSLTALPETLPPGL----KTLEAGeNALTSLPASL 344

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 77415462  214 lcgLGELRELDLSRNALRSVKANVfihLPRLQKLYLDRNLITAVaPRAFLGmkALRWLDLSHNRVAGLLEdTFPGLLG 291
Cdd:PRK15370 345 ---PPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNL-PENLPA--ALQIMQASRNNLVRLPE-SLPHFRG 412
LRR_8 pfam13855
Leucine rich repeat;
219-278 6.27e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 6.27e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462   219 ELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRV 278
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-256 2.02e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 2.02e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  79 LWLDGNNLSSIPS-AAFQNLSSLDflnLQGSWLRSLEpqALLGLQNLYHLHLERNLLRSLAaGLfRHTPSLASLSLGNNL 157
Cdd:cd21340   7 LYLNDKNITKIDNlSLCKNLKVLY---LYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIE-NL-ENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 158 LGRLEeGLfRGLSHLWDLNLGW------NSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPalLCGLGELRELDLSRNALR 231
Cdd:cd21340  80 ISVVE-GL-ENLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                       170       180
                ....*....|....*....|....*..
gi 77415462 232 SVK--ANVFIHLPRLQKLYLDRNLITA 256
Cdd:cd21340 156 DLEelLDLLSSWPSLRELDLTGNPVCK 182
LRRNT smart00013
Leucine rich repeat N-terminal domain;
40-78 1.14e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.23  E-value: 1.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 77415462     40 QCPVTCTCSyddytdELSVFCSSRNLTQLPDGIPVSTRA 78
Cdd:smart00013   1 ACPAPCNCS------GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 40-73 1.20e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 44.16  E-value: 1.20e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 77415462    40 QCPVTCTCSyddytdELSVFCSSRNLTQLPDGIP 73
Cdd:pfam01462   1 ACPVPCHCS------ATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-300 1.14e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 1.14e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  93 AFQNLSSLDFLNLQGSWLRSLePQALLGLQNLYHLHLERNLLRSLAAGLFRHTpSLASLSLGNNLLGRLEEGLFrGLSHL 172
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTDLPEELG-NLTNL 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 173 WDLNLGWNSLVVLPDTvFQGLGNLHELVLAGNKLTYLqPALLCGLGELRELDLSRNALRSVKAnvFIHLPRLQKLYLDRN 252
Cdd:COG4886 185 KELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 77415462 253 LITAVAPRAFLgmKALRWLDLSHNRVAGLLEDTFPGLLGLHVLRLAHN 300
Cdd:COG4886 261 QLTDLPPLANL--TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-300 1.44e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.44e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  53 TDELSVFCSSRNLTQLPDGIPVSTRALWLDGNNLSSIPSAAFQNLSSLDFLNLQGswlrslePQALLGLQNLYHLHLERN 132
Cdd:COG4886  51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGN 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 133 LLRSLAAGLFRHTpSLASLSLGNNLLGRLEEGLFrGLSHLWDLNLGWNSLVVLPDtVFQGLGNLHELVLAGNKLTYLqPA 212
Cdd:COG4886 124 QLTDLPEELANLT-NLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PE 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 213 LLCGLGELRELDLSRNALRSVKANvFIHLPRLQKLYLDRNLITAVAprAFLGMKALRWLDLSHNRVAGLleDTFPGLLGL 292
Cdd:COG4886 200 PLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLTNL 274


                ....*...
gi 77415462 293 HVLRLAHN 300
Cdd:COG4886 275 KTLDLSNN 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-300 7.21e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 7.21e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  79 LWLDGNNLSSIPsAAFQNLSSLDFLNLQGSWLRSLePQALLGLQNLYHLHLERNLLRSLAAGLFRHTpSLASLSLGNNLL 158
Cdd:COG4886 118 LDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLSNNQI 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 159 GRLEEGLFrGLSHLWDLNLGWNSLVVLPDTvFQGLGNLHELVLAGNKLTYLqpALLCGLGELRELDLSRNALRSVKANVf 238
Cdd:COG4886 195 TDLPEPLG-NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA- 269

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 77415462 239 iHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDTFPGLLGLHVLRLAHN 300
Cdd:COG4886 270 -NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-259 1.73e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 1.73e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  61 SSRNLTQLPDGIPVST--RALWLDGNNLSSIPSAaFQNLSSLDFLNLQGSWLRSLePQALLGLQNLYHLHLERNLLRSLA 138
Cdd:COG4886 121 SGNQLTDLPEELANLTnlKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 139 AGLFRHTpSLASLSLGNNLLGRLEEGLfRGLSHLWDLNLGWNSLVVLPDtvFQGLGNLHELVLAGNKLTYLQPalLCGLG 218
Cdd:COG4886 199 EPLGNLT-NLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLT 272

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 77415462 219 ELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAP 259
Cdd:COG4886 273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-300 1.65e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 1.65e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  56 LSVFCSSRNLTQLPDGIPVSTRALWLDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLERNLLr 135
Cdd:COG4886  30 LLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE- 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 136 slaaglFRHTPSLASLSLGNNLLGRLEEGLFRgLSHLWDLNLGWNSLVVLPDtVFQGLGNLHELVLAGNKLTYLqPALLC 215
Cdd:COG4886 109 ------LSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELG 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 216 GLGELRELDLSRNALRSVKAnVFIHLPRLQKLYLDRNLITAVaPRAFLGMKALRWLDLSHNRVAGLLEdtFPGLLGLHVL 295
Cdd:COG4886 180 NLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEEL 255


                ....*
gi 77415462 296 RLAHN 300
Cdd:COG4886 256 DLSNN 260
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
55-291 1.88e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.41  E-value: 1.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462   55 ELSVfcSSRNLTQLPDGIPVSTRALWLDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQallGLQnlyHLHLERNLL 134
Cdd:PRK15370 224 TLYA--NSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPE---ELR---YLSVYDNSI 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  135 RSLAAglfrHTPSlaslslgnnllgrleeglfrGLSHLWDLNlgwNSLVVLPDTVFQGLgnlhELVLAG-NKLTYLQPAL 213
Cdd:PRK15370 296 RTLPA----HLPS--------------------GITHLNVQS---NSLTALPETLPPGL----KTLEAGeNALTSLPASL 344

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 77415462  214 lcgLGELRELDLSRNALRSVKANVfihLPRLQKLYLDRNLITAVaPRAFLGmkALRWLDLSHNRVAGLLEdTFPGLLG 291
Cdd:PRK15370 345 ---PPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNL-PENLPA--ALQIMQASRNNLVRLPE-SLPHFRG 412
LRR_8 pfam13855
Leucine rich repeat;
219-278 6.27e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 6.27e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462   219 ELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRV 278
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
85-300 6.61e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 6.61e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  85 NLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLERNLLRSLAAGLFRHTPSLASLSLGNNLLGRLEEg 164
Cdd:COG4886  13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD- 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 165 lFRGLSHLWDLNLGWNSLvvlpdtvFQGLGNLHELVLAGNKLTYLqPALLCGLGELRELDLSRNALRSVKANVFiHLPRL 244
Cdd:COG4886  92 -LGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNL 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 77415462 245 QKLYLDRNLITAVaPRAFLGMKALRWLDLSHNRVAGlLEDTFPGLLGLHVLRLAHN 300
Cdd:COG4886 162 KSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITD-LPEPLGNLTNLEELDLSGN 215
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-300 1.10e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462   61 SSRNLT-QLPDGI---PVSTRALWLDGNNLS-SIPSAAFQNL---------------------SSLDFLNLQGSWLRSLE 114
Cdd:PLN00113 101 SNNQLSgPIPDDIfttSSSLRYLNLSNNNFTgSIPRGSIPNLetldlsnnmlsgeipndigsfSSLKVLDLGGNVLVGKI 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  115 PQALLGLQNLYHLHLERNLLRSLAAGLFRHTPSLASLSLG-NNLLGRLEEGLfRGLSHLWDLNLGWNSLVVLPDTVFQGL 193
Cdd:PLN00113 181 PNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGyNNLSGEIPYEI-GGLTSLNHLDLVYNNLTGPIPSSLGNL 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  194 GNLHELVLAGNKLTYLQPALLCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDL 273
Cdd:PLN00113 260 KNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQL 339

                        250       260       270
                 ....*....|....*....|....*....|.
gi 77415462  274 SHNRVAGlledTFPGLLGLH----VLRLAHN 300
Cdd:PLN00113 340 WSNKFSG----EIPKNLGKHnnltVLDLSTN 366
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-256 2.02e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.50  E-value: 2.02e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  79 LWLDGNNLSSIPS-AAFQNLSSLDflnLQGSWLRSLEpqALLGLQNLYHLHLERNLLRSLAaGLfRHTPSLASLSLGNNL 157
Cdd:cd21340   7 LYLNDKNITKIDNlSLCKNLKVLY---LYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIE-NL-ENLVNLKKLYLGGNR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 158 LGRLEeGLfRGLSHLWDLNLGW------NSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPalLCGLGELRELDLSRNALR 231
Cdd:cd21340  80 ISVVE-GL-ENLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS 155

                       170       180
                ....*....|....*....|....*..
gi 77415462 232 SVK--ANVFIHLPRLQKLYLDRNLITA 256
Cdd:cd21340 156 DLEelLDLLSSWPSLRELDLTGNPVCK 182
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-285 6.92e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 6.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462   61 SSRNLT-QLPDGIPVSTR--ALWLDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLERNLLRSL 137
Cdd:PLN00113 364 STNNLTgEIPEGLCSSGNlfKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGR 443

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  138 AAGLFRHTPSLASLSLG-NNLLGRLEEglFRGLSHLWDLNLGWNSLvvlPDTVFQGLGNLHELV---LAGNKLTYLQPAL 213
Cdd:PLN00113 444 INSRKWDMPSLQMLSLArNKFFGGLPD--SFGSKRLENLDLSRNQF---SGAVPRKLGSLSELMqlkLSENKLSGEIPDE 518

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 77415462  214 LCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDT 285
Cdd:PLN00113 519 LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPST 590
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-300 1.28e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462   62 SRNLT-QLPDGIPVSTR--ALWLDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLERNLLRSLA 138
Cdd:PLN00113 317 SNNFTgKIPVALTSLPRlqVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEI 396

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  139 AGLFRHTPSLASLSL-GNNLLGRLEEGlFRGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALLcGL 217
Cdd:PLN00113 397 PKSLGACRSLRRVRLqDNSFSGELPSE-FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSF-GS 474

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  218 GELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDTFPGLLGLHVLRL 297
Cdd:PLN00113 475 KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDL 554


                 ...
gi 77415462  298 AHN 300
Cdd:PLN00113 555 SQN 557
LRR_8 pfam13855
Leucine rich repeat;
122-182 1.79e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 1.79e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77415462   122 QNLYHLHLERNLLRSLAAGLFRHTPSLASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSL 182
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
195-254 3.89e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 3.89e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462   195 NLHELVLAGNKLTYLQPALLCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLI 254
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
242-300 6.98e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 6.98e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 77415462   242 PRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDTFPGLLGLHVLRLAHN 300
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
146-206 1.20e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.20e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77415462   146 PSLASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKL 206
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
170-230 8.67e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 8.67e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77415462   170 SHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALLCGLGELRELDLSRNAL 230
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 131-300 3.11e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 3.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  131 RNLLRSLAAGLFrHTPSLASLSLGNNLL-GRLEEGLFRGLSHLWDLNLGWNSLVvlpDTVFQG-LGNLHELVLAGNKLTY 208
Cdd:PLN00113  79 KNISGKISSAIF-RLPYIQTINLSNNQLsGPIPDDIFTTSSSLRYLNLSNNNFT---GSIPRGsIPNLETLDLSNNMLSG 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  209 LQPALLCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDTFPG 288
Cdd:PLN00113 155 EIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGG 234

                        170
                 ....*....|..
gi 77415462  289 LLGLHVLRLAHN 300
Cdd:PLN00113 235 LTSLNHLDLVYN 246
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 116-278 3.63e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.82  E-value: 3.63e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 116 QALLGLQNLYHLHLERNLL-----RSLAAGLFRHTPSLASLSLGNNLL-GRLEE---GLFRGLSHLWDLNLGWNSLVV-L 185
Cdd:cd00116 102 ESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLeGASCEalaKALRANRDLKELNLANNGIGDaG 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 186 PDTVFQGL---GNLHELVLAGNKLTYLQPALLCG----LGELRELDLSRNALRSVKANVF-----IHLPRLQKLYLDRNL 253
Cdd:cd00116 182 IRALAEGLkanCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCND 261

                       170       180
                ....*....|....*....|....*....
gi 77415462 254 ITAVAPRAFLG----MKALRWLDLSHNRV 278
Cdd:cd00116 262 ITDDGAKDLAEvlaeKESLLELDLRGNKF 290
LRRNT smart00013
Leucine rich repeat N-terminal domain;
40-78 1.14e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.23  E-value: 1.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 77415462     40 QCPVTCTCSyddytdELSVFCSSRNLTQLPDGIPVSTRA 78
Cdd:smart00013   1 ACPAPCNCS------GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 40-73 1.20e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 44.16  E-value: 1.20e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 77415462    40 QCPVTCTCSyddytdELSVFCSSRNLTQLPDGIP 73
Cdd:pfam01462   1 ACPVPCHCS------ATVVNCSDRGLTAVPRDLP 28
LRR_8 pfam13855
Leucine rich repeat;
81-134 1.91e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 1.91e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 77415462    81 LDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLERNLL 134
Cdd:pfam13855   8 LSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
98-158 3.66e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 3.66e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77415462    98 SSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLERNLLRSLAAGLFRHTPSLASLSLGNNLL 158
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 121-300 2.93e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 2.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 121 LQNLYHLHLERNLLRSLaaGLFRHTPSLASLSLGNNLLGRLEEglFRGLSHLWDLNLGWNSLVVLPDtvFQGLGNLHELV 200
Cdd:cd21340   1 LKRITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 201 LAGNKLTylqpaLLCGLG---ELRELDLSRNalrsvkanvfiHLPRLQKLYLDRNLITAVAPRaflgmkaLRWLDLSHNR 277
Cdd:cd21340  75 LGGNRIS-----VVEGLEnltNLEELHIENQ-----------RLPPGEKLTFDPRSLAALSNS-------LRVLNISGNN 131

                       170       180
                ....*....|....*....|...
gi 77415462 278 VAGLleDTFPGLLGLHVLRLAHN 300
Cdd:cd21340 132 IDSL--EPLAPLRNLEQLDASNN 152
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
65-296 5.84e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.38  E-value: 5.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462   65 LTQLPDGIPVSTRALWLDGNNLSSIPSAAfqnlSSLDFLNLQGSWLRSLePQALLGLQNLYHLHLERNLLRSLAAGLFR- 143
Cdd:PRK15387 213 LTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTSL-PVLPPGLLELSIFSNPLTHLPALPSGLCKl 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  144 ------------HTPSLASLSLGNNLLGRLeEGLFRGLSHLWDLNLGWNSLVVLPDtvfqglgNLHELVLAGNKLTYLqP 211
Cdd:PRK15387 288 wifgnqltslpvLPPGLQELSVSDNQLASL-PALPSELCKLWAYNNQLTSLPTLPS-------GLQELSVSDNQLASL-P 358

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  212 ALlcgLGELRELDLSRNALRSVKAnvfihLPR-LQKLYLDRNLITA--VAPraflgmKALRWLDLSHNRVAGLleDTFP- 287
Cdd:PRK15387 359 TL---PSELYKLWAYNNRLTSLPA-----LPSgLKELIVSGNRLTSlpVLP------SELKELMVSGNRLTSL--PMLPs 422


                 ....*....
gi 77415462  288 GLLGLHVLR 296
Cdd:PRK15387 423 GLLSLSVYR 431
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 143-300 8.01e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 8.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 143 RHTPSLASLSLGNNLLGRLEEGL------FRGLSHLWDLNLGWNSLVVLPDTVFQGL---GNLHELVLAGNKLTYLQPAL 213
Cdd:cd00116  48 RPQPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRL 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 214 LC-GLGE----LRELDLSRNALRSVK----ANVFIHLPRLQKLYLDRNLITAVAPRA-FLGMKA---LRWLDLSHNRV-- 278
Cdd:cd00116 128 LAkGLKDlppaLEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRAlAEGLKAncnLEVLDLNNNGLtd 207

                       170       180
                ....*....|....*....|....
gi 77415462 279 --AGLLEDTFPGLLGLHVLRLAHN 300
Cdd:cd00116 208 egASALAETLASLKSLEVLNLGDN 231
PLN03150 PLN03150
hypothetical protein; Provisional
 223-300 1.35e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 1.35e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 77415462  223 LDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDTFPGLLGLHVLRLAHN 300
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGN 500
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 123-261 1.59e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 1.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 123 NLYHLHLERNLLRSLAAGLFRHTpSLASLSLGNNLLG-----RLEEGLfRGLSHLWDLNLGWNSL----VVLPDTVFQGL 193
Cdd:COG5238 270 YLSGNQIGAEGAIALAKALQGNT-TLTSLDLSVNRIGdegaiALAEGL-QGNKTLHTLNLAYNGIgaqgAIALAKALQEN 347

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 77415462 194 GNLHELVLAGNKLTYLQPALLC----GLGELRELDLSRNALRSVKANVFIHL---PRLQKLYLDRNLITAVAPRA 261
Cdd:COG5238 348 TTLHSLDLSDNQIGDEGAIALAkyleGNTTLRELNLGKNNIGKQGAEALIDAlqtNRLHTLILDGNLIGAEAQQR 422
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 58-300 2.64e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.00  E-value: 2.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  58 VFCSSRNLTQLPDGIPVstralwldgNNLSSIPSAAFQNLSSLDFLNLQGSwlRSLEPQALLGLQNLYHLHLERNLLRSL 137
Cdd:COG5238  79 EKAAEAFPTQLLVVDWE---------GAEEVSPVALAETATAVATPPPDLR--RIMAKTLEDSLILYLALPRRINLIQVL 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 138 --AAGLFRHTPSLASLSLGNNLLGRLEEGLFRGLSHLWDL---NLGWNSLVVLPDTVFQGlGNLHELVLAGNKLTYLQP- 211
Cdd:COG5238 148 kdPLGGNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLgcnQIGDEGIEELAEALTQN-TTVTTLWLKRNPIGDEGAe 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 212 ---ALLCGLGELRELDLSRNALR----SVKANVFIHLPRLQKLYLDRNLITAVAPRAFL----GMKALRWLDLSHNRV-- 278
Cdd:COG5238 227 ilaEALKGNKSLTTLDLSNNQIGdegvIALAEALKNNTTVETLYLSGNQIGAEGAIALAkalqGNTTLTSLDLSVNRIgd 306

                       250       260
                ....*....|....*....|....
gi 77415462 279 --AGLLEDTFPGLLGLHVLRLAHN 300
Cdd:COG5238 307 egAIALAEGLQGNKTLHTLNLAYN 330
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-258 2.74e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.15  E-value: 2.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462  60 CSSRNLTQLPDGIPVST--RALWLDGNNLSSIPS-AAFQNLSSLDflnLQGSWLRSLEPqaLLGLQNLYHLHLERNLLRS 136
Cdd:COG4886 212 LSGNQLTDLPEPLANLTnlETLDLSNNQLTDLPElGNLTNLEELD---LSNNQLTDLPP--LANLTNLKTLDLSNNQLTD 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77415462 137 LAagLFRHTPSLASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALLCG 216
Cdd:COG4886 287 LK--LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 77415462 217 LGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVA 258
Cdd:COG4886 365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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