|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
16-404 |
1.00e-126 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 371.63 E-value: 1.00e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 16 FWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFL 95
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 96 CAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMPAALAWRVMF 175
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 176 GVGLLPALLIVYVRRGIVEPSTDAPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVGAHGGYYALMTWLPTYLKVER 255
Cdd:cd17371 161 LLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 256 HLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGIPASM 335
Cdd:cd17371 241 GLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGM 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 772975805 336 GALFNELYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIGIDAAIAYSIVVAAVLMLPET 404
Cdd:cd17371 321 GAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
16-399 |
4.21e-55 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 186.27 E-value: 4.21e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 16 FWACFGGWALDALDVQMFSLVIPAIIAE--WSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGT 93
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 94 FLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMPAALAWRV 173
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 174 MFGVGLLPALLIVYVRrgivepstdapktpaasqaaaaaplvgifaretlRMTLIGALLGVGAHGGYYALMTWLPTYLKV 253
Cdd:cd17316 161 LFLIGALPALLALLLR----------------------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQT 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 254 ERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAM-LVLGFPLGFFAAGIP 332
Cdd:cd17316 207 VLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLlLLLLFILSFFVGGVW 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 772975805 333 ASMGALFNELYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIGIDAAIAYSIVVAAVL 399
Cdd:cd17316 287 GALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-405 |
3.01e-47 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 165.81 E-value: 3.01e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 7 AISARERRTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTI 86
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 87 AFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSawavGWAAAVLLYALAFSLMP 166
Cdd:COG2271 83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNA----GGPLGGALAPPLLGWLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 167 AALAWRVMFGVGLLPALLIVYVRrgivepstdapktpaasqaaaaaplvgifaretlrmTLIGALLGVGAHGGYYALMTW 246
Cdd:COG2271 159 AAFGWRAAFLILGLPGLLLALLR------------------------------------FWLLALAYFLVYFALYGFLTW 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 247 LPTYLKVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAML-VLGFPLG 325
Cdd:COG2271 203 LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAiALLFLAG 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 326 FFAAGIPASMGALFNELYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIGIDAAIAYSIVVAAVLMLPETR 405
Cdd:COG2271 283 FGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
14-373 |
3.49e-46 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 164.07 E-value: 3.49e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 14 RTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGT 93
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 94 FLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYalafSLMPAALAWRV 173
Cdd:TIGR00895 97 LLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLA----GWLIPVFGWRS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 174 MFGVG-LLPALLIVYVRRGIVEP--------------------------STDAPKTPAASQAAAAAPLVGIFARETLRMT 226
Cdd:TIGR00895 173 LFYVGgIAPLLLLLLLMRFLPESidflvskrpetvrrivnaiapqmqaeAQSALPEQKSTQGTKRSVFKALFQGKTARIT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 227 LIGALLGVGAHGGYYALMTWLPtYLKVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIA 306
Cdd:TIGR00895 253 VLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLV 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 772975805 307 YLFLpLGNAAMLVLGFPLGFFAAGIPASMGALFNELYPRGTRGTGVGFCYNFGRVASAGFPVLVGHM 373
Cdd:TIGR00895 332 GSTL-FSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-364 |
9.84e-38 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 140.11 E-value: 9.84e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 7 AISARERRTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTI 86
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 87 AFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYalafSLMP 166
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG----GLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 167 AALAWRVMFGVGLLPALLIVYVRRGIVEPSTDAPKTPAASQAAAAAplvgifareTLRMTLIGALLGVGAHGGYYALMTW 246
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELL---------RRPRLLLLLLLAFLLGFGFFALFTY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 247 LPTYLKVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPlGNAAMLVLGFPLGF 326
Cdd:COG2814 230 LPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG-SLWLLLLALFLLGF 308
|
330 340 350
....*....|....*....|....*....|....*...
gi 772975805 327 FAAGIPASMGALFNELYPRGTRGTGVGFCYNFGRVASA 364
Cdd:COG2814 309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| 2A0112 |
TIGR00891 |
putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic ... |
4-369 |
3.43e-33 |
|
putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273324 [Multi-domain] Cd Length: 405 Bit Score: 128.85 E-value: 3.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 4 WFGAISARERRTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQ 83
Cdd:TIGR00891 2 WYRHLTRAQWNAFSAAWLGWLLDAFDFFLVALVLAEVAGEFGLTTVDAASLISAALISRWFGALMFGLWGDRYGRRLPMV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 84 WTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFS 163
Cdd:TIGR00891 82 TSIVLFSAGTLACGFAPGYITMFIARLVIGIGMGGEYGSSAAYVIESWPKHLRNKASGLLISGYAVGAVVAAQVYSLVVP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 164 LMpaALAWRVMFGVGLLPALLIVYVRRGIVEPS-------------TDAPKTPA--ASQAAAAAPLVGIFARETLRMTLI 228
Cdd:TIGR00891 162 VW--GDGWRALFFISILPIIFALWLRKNIPEAEdwkekhagkalvrTMVDILYGgeHRIANIVMTLAAAMVQSAGKRWPT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 229 GALLGVGAHGGYYalMTW-----LPTYLKVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTIlVFSACCVAT 303
Cdd:TIGR00891 240 FVYLVVLVLFANL--YSHpiqdlLPTYLKADLGLSPHTVANIVVFSNIGAIVGGCVFGFLGDWLGRRKAY-VCSLLAGQL 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 772975805 304 VIAYLFLPLGNAAMLVLG-FPLGFFAAGIPASMGALFNELYPRGTRGTGVGFCYNFGRVASAGFPVL 369
Cdd:TIGR00891 317 LIIPVFAIGANVAVLGLGlFFQQMLVQGIWGILPKHLGEYFPTDQRAAGLGFTYQLGNLGGALAPII 383
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
19-401 |
1.64e-32 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 125.78 E-value: 1.64e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 19 CFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAF 98
Cdd:cd17365 4 CFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 99 ATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYalafSLMPAALAWRVMFGVG 178
Cdd:cd17365 84 AQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLA----AALIPAFGWRSVFLLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 179 LLPALLIVyvrrgivepstdapktpaasqaaaaaPLVGIfaretlrmTLIGALLGVGAHGGYYALMTWLPTyLKVERHLS 258
Cdd:cd17365 160 GVPPLILL--------------------------PLLRG--------TLLLWVTFFMGLLLVYLLNSWLPK-LMVEAGYS 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 259 VLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGIPASMGAL 338
Cdd:cd17365 205 LSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYAL 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 772975805 339 FNELYPRGTRGTGVGFCYNFGRVASAGFPVLVGH-MSAGMPLGTAIGIDAAIAysiVVAAVLML 401
Cdd:cd17365 285 AARFYPTEVRATGVGWALGVGRLGAILGPLLGGLlLAAGLGPESVFLALAIPA---ALGALAVL 345
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
4-385 |
3.56e-31 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 124.81 E-value: 3.56e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 4 WFGAISARERRTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQ 83
Cdd:PRK03893 10 WYRHLNRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 84 WTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLyalaFS 163
Cdd:PRK03893 90 ISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQV----YS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 164 LMPAALAWRVMFGVGLLPALLIVYVRRGIVEPS----TDAPKTPA-----------------ASQAAAAAPLVGIFARET 222
Cdd:PRK03893 166 LVVPVWGWRALFFIGILPIIFALWLRKNLPEAEdwkeKHAGKAPVrtmvdilyrgehriiniLLTLAAAAALWFCFAGNL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 223 LRmTLIGALLGVGAHGGYYALM------------------------TW-----LPTYLKVERHLSVLGTGGYLAVIIVAF 273
Cdd:PRK03893 246 QN-AAIVAVLGLLCAAIFISFMvqssgkrwptgvmlmvvvlfaflySWpiqalLPTYLKTDLGYDPHTVANVLFFSGFGA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 274 FCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAML-VLGFPLGFFAAGIPASMGALFNELYPRGTRGTGV 352
Cdd:PRK03893 325 AVGCCVGGFLGDWLGTRKAYVCSLLISQLLIIPVFAIGGANVWVLgLLLFFQQMLGQGISGLLPKLIGGYFDTEQRAAGL 404
|
410 420 430
....*....|....*....|....*....|...
gi 772975805 353 GFCYNFGRVASAGFPVLVGHMSAGMPLGTAIGI 385
Cdd:PRK03893 405 GFTYNVGALGGALAPILGALIAQRLDLGTALAS 437
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-373 |
2.87e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 117.67 E-value: 2.87e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 13 RRTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVG 92
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 93 TFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYalafSLMPAALAWR 172
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLA----PLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 173 VMFGV-GLLPALLIVYVRRGIVEPSTDAPKTPAASQAAAAAPLvgifareTLRMTLIGALLGVGAHGGYYALMTWLPTYL 251
Cdd:COG2223 160 NAFLIlGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEAL-------RDPRFWLLSLLYFGTFGSFIGFSSWLPPYL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 252 KVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGI 331
Cdd:COG2223 233 VDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGG 312
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 772975805 332 PASMGALFNELYPRGTRGTGVGFCYNFGRVASAGFPVLVGHM 373
Cdd:COG2223 313 NGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
2-385 |
1.02e-26 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 111.17 E-value: 1.02e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 2 FKWFGAISARERRTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRT 81
Cdd:PRK12307 6 FPWYSEITRPQKNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 82 LQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVllyala 161
Cdd:PRK12307 86 MMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAA------ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 162 fSLMPA---ALAWRVMFGVGLLPALLIVYVRRGIVEPS-------TDAPKTPAASQAAAAAPLVGIFARETLRMTLIGAL 231
Cdd:PRK12307 160 -YFMPSfaeAYGWRAAFFVGLLPVLLVIYIRARAPESKeweeaklSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTLCVFI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 232 LGVGAHGGYYALMTWLPTYLKVERH----LSVLGTGGYLAVIIVAFFCGCVAsahllDRIGRRSTILVFSACCVATVIAY 307
Cdd:PRK12307 239 VLFSIFGANWPIFGLLPTYLAGEGFdtgvVSNLMTAAAFGTVLGNIVWGLCA-----DRIGLKKTFSIGLLMSFLFIFPL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 772975805 308 LFLPLGNAAMLVLG-FPLGFFAAGIPASMGALFNELYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIGI 385
Cdd:PRK12307 314 FRIPQDNYLLLGAClFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMGLGAALTF 392
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-377 |
1.53e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 107.13 E-value: 1.53e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 20 FGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFA 99
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 100 TSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLmpAALAWRVMFGVGL 179
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS--LGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 180 LPALLIVYVRRgIVEPSTDAPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVGAHGGYYALMTWLPTYLKVERHLSV 259
Cdd:cd06174 160 ALALLAAILLL-LVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 260 LGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGIPASMGALF 339
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350
....*....|....*....|....*....|....*...
gi 772975805 340 NELYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGM 377
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT 356
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
25-401 |
2.58e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 103.42 E-value: 2.58e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 25 LDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQ 104
Cdd:cd17325 7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 105 FVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYalafSLMPAALAWRVMFGVGLLPALL 184
Cdd:cd17325 87 LLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLG----GLLADALGYRAPFLVCAALALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 185 IVYVRRGIVEPSTDAPKTPAASQAAAAAPLVGIFARETLrmtLIGALLGVGAHGGYYALMTWLPTYLKVERHLSVLGTGG 264
Cdd:cd17325 163 ALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRL---LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 265 YLAVIIVAFFCGCVASAHLLDRIGRRSTILvfsACCVATVIAYLFLPL-GNAAMLVLGFPL-GFFAAGIPASMGALFNEL 342
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLIL---IGLLLSAVALLLLPLaTSFWLLLLLLALlGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 772975805 343 YPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIGIDAAIAYSIVVAAVLML 401
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-367 |
4.34e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.50 E-value: 4.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 24 ALDALDVQMFSLVIPAIIAE-WSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSY 102
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEdLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 103 PQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYalafSLMPAALAWRVMFGVGLLPA 182
Cdd:pfam07690 86 WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLG----GLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 183 LLIVYVRRGIVEPSTDAPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVGAhggYYALMTWLPTYLKVeRHLSVLGT 262
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFA---FFGLLTYLPLYQEV-LGLSALLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 263 GGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPL--GNAAMLVLGFPLGFFAAGIPASMGALFN 340
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtlSSLWLLLALLLLGFGFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*..
gi 772975805 341 ELYPRGTRGTGVGFCYNFGRVASAGFP 367
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-298 |
3.88e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 95.65 E-value: 3.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 9 SARERRTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAF 88
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 89 FSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSawavGWAAAVLLYALAFSLMPAA 168
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGA----AIGLGLALGPLLGGLLVAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 169 LAWRVMFGVGLLPALLIVYVRRGIVEpSTDAPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVGAHGGYYALMTWLP 248
Cdd:COG0477 165 LGWRWIFLINAPLGLLALVLRLRLPE-SRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLL 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 772975805 249 TYLKVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSA 298
Cdd:COG0477 244 ALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
56-399 |
4.58e-22 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 97.21 E-value: 4.58e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 56 GATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQ--------FVILKTLQGLGFGGEWAAGAVLM 127
Cdd:cd17369 51 GVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilapilLVLLRLLQGLALGGEWGGAVLMA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 128 AETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMP----AALAWRVMFgvgLLPALLI---VYVRRGIVEpsTDAP 200
Cdd:cd17369 131 VEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLSdeafLSWGWRIPF---LLSAVLVavgLYIRLRLEE--TPVF 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 201 KTPAASQAAAAAPLVGIFaRETLRMTLIGALLGVGAHGGYYALMTWLPTYLKveRHLSVLGTGGYLAVII--VAFFCGCV 278
Cdd:cd17369 206 RRAKEAGQVVRAPLVEVL-RRHWRALLLAIGLRLAENVLFYLFTTFALSYAT--QTLGVDRSTVLLAVLIasVVAAITIP 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 279 ASAHLLDRIGRRSTILVFSACCVatVIAYLFLPL---GNAAMLVLGFPLGFFA--AGIPASMGALFNELYPRGTRGTGVG 353
Cdd:cd17369 283 LFGWLSDRVGRRPVYLAGALLAA--LFAFPFFWLldtGSTWLIVLAAVVVLGVlhGMMYGPQAAFLAELFPTRVRYTGAS 360
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 772975805 354 FCYNFGRVASAGFPVLVghmsaGMPLGTAIGIDAAIAYSIVVAAVL 399
Cdd:cd17369 361 LGYQLGAILGGGFAPLI-----ATALVAATGSWWPVALYLAALAVI 401
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
36-359 |
8.77e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 96.08 E-value: 8.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 36 VIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLG 115
Cdd:cd17324 21 LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 116 FGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYalafSLMPAALAWRVMF-GVGLLPALLIVYVRRGIve 194
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLG----GLLGQLLGWRAAFlAIAVLALLAALLLWRLL-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 195 PSTDAPKTPAASQAAAaapLVGIFARETLRMTLIGALLGVGAHggyYALMTWLPTYLKVERHLSVLGTGGYLAVIIVAFF 274
Cdd:cd17324 175 PSLPPKKPGSLGLLSS---LLLLLRNPRLRLAYLITFLLFGGF---FALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 275 CGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGnAAMLVLGFPLGFFAAGIPASMGALFNELYPRGtRGTGVG- 353
Cdd:cd17324 249 VGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSP-LLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSl 326
|
....*...
gi 772975805 354 --FCYNFG 359
Cdd:cd17324 327 ylAAYNLG 334
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
20-373 |
1.73e-21 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 94.94 E-value: 1.73e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 20 FGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFA 99
Cdd:cd17319 9 FLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 100 TSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSawavGWAAAVLLYALAFSLMPAALAWRVMFGVGL 179
Cdd:cd17319 89 TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNS----GAPLGAAIGPPLSGWLLLLFGWRWAFIIEG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 180 LPALLIvyvrrgivepstdapktpaasqaaaaaplvGIFARETLRMTLIGALLGVGAHGGYYALMTWLPTYLKVERHLSV 259
Cdd:cd17319 165 LLGLLL------------------------------AVLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 260 LGTGGYLAVIIVAFFCGCVASAHLLDR-IGRRSTILVFSACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGIPASMG-A 337
Cdd:cd17319 215 KQVGLLAAIPFLAGAIGMILGGRLSDRlLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFwS 294
|
330 340 350
....*....|....*....|....*....|....*.
gi 772975805 338 LFNELYPRGTRGTGVGFCYNFGRVASAGFPVLVGHM 373
Cdd:cd17319 295 LPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYL 330
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
19-401 |
2.22e-21 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 95.41 E-value: 2.22e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 19 CFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGA----TLVASAIGGWaagmLSDRFGRVRTLQWTIAFFSVGTF 94
Cdd:PRK11551 20 CFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAgilgLLPGALLGGR----LADRIGRKRILIVSVALFGLFSL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 95 LCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYAlafsLMPAALAWRVM 174
Cdd:PRK11551 96 ATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGV----LAAGDAAWRHI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 175 FGVGLLPALLIVYVrRGIVEPSTDAPKTPAASQAAAAAPLVGIFARETLRMTLigaLLGVGAHGG---YYALMTWLPTyL 251
Cdd:PRK11551 172 FYVGGVGPLLLVPL-LMRWLPESRAFAQAAGAGKQRAPVLRALFGEGRATATL---LLWISYFFTlivLYFLLNWLPS-L 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 252 KVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPlGNAAMLVLGFPLGFFAAGI 331
Cdd:PRK11551 247 LVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILASLAALAAAP-SFAGMLLAGFAAGLFVVGG 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 772975805 332 PASMGALFNELYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAgmpLGT-AIGIDAAIAYSIVVAAVLML 401
Cdd:PRK11551 326 QSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLA---LGRsTVGVIGASIPVILVAALAAL 393
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
13-408 |
5.46e-21 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 94.15 E-value: 5.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 13 RRTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVG 92
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 93 TFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAEtIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMPAALAWR 172
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 173 VMFGVGLLPALLIVYVRRGivepSTDAPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVGAHGgyyALMTWLPTYLK 252
Cdd:COG0738 166 PYLILAVLLLLLALLFLRS----KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEG---AIGDWLPLYLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 253 VERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIayLFLPLGNAAMLVLGFPL-GFFAAGI 331
Cdd:COG0738 239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL--LALLAPGPWLALIGLALvGLGLSLM 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 772975805 332 -PASMGALFNELYPRGTRGTGVGFCynFGRVASAGFPVLVGHMSAGMPLGTAIGIdAAIAYSIVVAAVLMLPETRGRA 408
Cdd:COG0738 317 fPTIFSLALDGLGKRTAAAVSAVLI--MGIVGGAIGPPLIGFLADAFGLRAAFLV-PLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
45-355 |
1.34e-18 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 86.86 E-value: 1.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 45 SLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGA 124
Cdd:cd17315 30 GLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVP 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 125 VLMAETIRAEHRGkAMGTVQSAWAVGWAAAVLLYALAFSLMPAALaWRVMFGVGLLPALLIVyvrrgivepstdapktpa 204
Cdd:cd17315 110 LYISEIAPAKIRG-ALGTLNQLMITFGILLAYLLGLALSLSPPGW-WRLMFALAAVPALLQL------------------ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 205 asqaaaaapLVGIFARETLRMTLIGALLGVGAHGGYYALMTWLPTYLK--VERHLSVLGTggylAVIIVAFFCGCVASAH 282
Cdd:cd17315 170 ---------LLMFFLPESRALLVGVGLQLLQQLTGINAVMYYAPTIFKsaGGGTASILAS----IIVGVVNLLATLVAIR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 283 LLDRIGRRS----TILVFSACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGIPASMGALFN----ELYPRGTRGTGVGF 354
Cdd:cd17315 237 LVDKVGRRPllliGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWlllsEIFPLRIRGKGMAI 316
|
.
gi 772975805 355 C 355
Cdd:cd17315 317 A 317
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
57-405 |
1.75e-18 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 86.96 E-value: 1.75e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 57 ATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQ--------FVILKTLQGLGFGGEWAAGAVLMA 128
Cdd:cd17367 48 VGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLSVGGEYGTSATYLS 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 129 ETIRAEHRGKAMGTVQ-SAWAVGWAAAVLLYALAFSLMPAAL---AWRVMFGVGLLPALLIVYVRRGIVEPSTDAPKTPA 204
Cdd:cd17367 128 EVAPPGRRGFYSSFQYvTLIGGQLLALGVLLVLQHTLGEDQMaawGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAES 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 205 ASQAAAAAPLVGIFARETLRMTLIGAllgvGAHGGYYALMTWLPTYLKVERHLSVLGTGGYLAVIIVAFFCGCVASAHLL 284
Cdd:cd17367 208 NEASAGTLRELRRHPRELLLVVGLTA----GGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLS 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 285 DRIGRRSTILVFS-ACCVATVIAYLFLPLGNAAMLVLGFPL--GFFAAGIPASMGALFNELYPRGTRGTGVGFCYN---- 357
Cdd:cd17367 284 DRIGRRPLLLFFGiGGTLATVPLLSALDHTDSPYTAFALVLvgLVFLSGYTSINAVVKAELFPTHVRALGVGLPYAlava 363
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 772975805 358 -FGRVASAgfpVLVGHMSAGMPLGTAIGIDAAIAYSIVVaaVLMLPETR 405
Cdd:cd17367 364 iFGGTAPY---VALWLKSIGHEWVFFWYVAGLIAISLVV--YLRMPETR 407
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
30-400 |
3.14e-17 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 82.62 E-value: 3.14e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 30 VQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILK 109
Cdd:cd17474 15 VSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 110 TLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAfslmpAALAWRVMFGVGLLPALLIVYVR 189
Cdd:cd17474 95 ALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-----AAISWRYPFFLLAALIPVAFLAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 190 RGIVEPStdaPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVgahGGYYALMTWLPTYLKVERHLSVLGTGGYLAVI 269
Cdd:cd17474 170 LFLLPEP---KEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYF---FLYFAFLTYLPFLLELLYGISPIIIGLLFAGW 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 270 IVAFFCGCVASAHLLDRIGRRSTILVFSACCVAtVIAYLFLPLGNAAMLVLGFPLGFFAAGI-PASMGALFNELYPRGTR 348
Cdd:cd17474 244 SVLLALGSLFVGRLLKKRFGARRILVIGLLLYA-LSLLLLGFVPSLALLLIAIVLFGLGLGLnLPLLTTLVTELAPEEER 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 772975805 349 GTGVGFcYNFGRVASAGF-PVLVGHMSAGMPLGTAIGIDAAIAYSIVVAAVLM 400
Cdd:cd17474 323 GTASSL-YNFVRFLGQAVgPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
15-403 |
9.85e-17 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 81.46 E-value: 9.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 15 TFWACFGGwALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTF 94
Cdd:cd17359 3 SLVAALGG-LLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 95 LCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMPAAL----A 170
Cdd:cd17359 82 GSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWlgaeG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 171 WRVMFGVGLLPA---LLIVYVrrgivepstdAPKTPAAsqaaaaaplvgiFARETLRMTLIGALLGV-GAHGGYYALMTW 246
Cdd:cd17359 162 WRWMLGLEAIPAilfLLGMLF----------IPESPRW------------LVSKGKPILIIGIGLAIfQQFVGINVIFYY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 247 LPTYLKverHLSVLGTGGYLAVIIVAFF--CGCVASAHLLDRIGRRSTILVFSACCVAT----VIAYLFLPLGNAAMLVL 320
Cdd:cd17359 220 GPEIFQ---NAGFSENAALLQTIGIGVVnvIFTIIAILLVDKVGRKPLLLIGSIGMAISllliGTAFYFAPGSQASGIVA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 321 GFPLGFFAAGIPASMGA----LFNELYPRGTRGTGVGFCYNFGRVA----SAGFPVLVGHMSagmpLGTAIGIDAAIAYS 392
Cdd:cd17359 297 LVLILLFVAFFAMSWGPvtwvLLSEIFPNRIRGLAMGIAVFFLWIAnflvSLTFPILLAAFG----LAFTFLIFAVICVL 372
|
410
....*....|.
gi 772975805 393 IVVAAVLMLPE 403
Cdd:cd17359 373 AFLFVWKFVPE 383
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
36-371 |
4.27e-16 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 79.53 E-value: 4.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 36 VIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLG 115
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 116 FggewAAGAVLMAETIR---AEHRGKAMGTVQSAWAVGWAAAVLLYALAFslmpAALAWRVMFGVGLLPALLIVYVRRGI 192
Cdd:COG2807 120 I----AVGNVLLPGLIKrwfPDRVGLMTGLYTAAMGLGAALAAGLTVPLA----AALGWRGALAVWALLALLALLLWLPL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 193 VePSTDAPKTPAASQAAAAAPLvgiFARETLRMTLIGALLGvgahGGYYALMTWLPTYLkVERHLSVLGTGGYLAVIIVA 272
Cdd:COG2807 192 L-RRRPAAAAAAPAAASLRSLW---RSPLAWLLTLFFGLQS----LLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLA 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 273 FFCGCVASAHLLDRIG-RRSTILVFSACCVATVIAYLFLPLgnAAMLVLGFPLGFFAAGIPASMGALFNELYPRGTR-GT 350
Cdd:COG2807 263 GIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPG--SLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAA 340
|
330 340
....*....|....*....|.
gi 772975805 351 GVGFCYNFGRVASAGFPVLVG 371
Cdd:COG2807 341 LSGMAQSVGYLLAALGPLLVG 361
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
22-381 |
6.39e-16 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 78.73 E-value: 6.39e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 22 GWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATS 101
Cdd:cd17372 7 GWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 102 YPQFVILKTLQGLGFGGEwAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALafsLMPaALAWRVMFGVGLLP 181
Cdd:cd17372 87 YMWLIILRCLVGLGLGGG-PQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWL---VMP-RLGWRWLLAFSSVP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 182 ALLIVYVRRGIvepstdaPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVGAHGGYYALMTwlptylKVERHLSVLG 261
Cdd:cd17372 162 SSLLLVFYRWT-------PKTTLLLWVIWFGNAFAYYGVVLLTTELNNSHNVCGSKSDSDSGES------PTEKQCRNSN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 262 TGGYLAVIIVAF--FCGCVASAHLLDRIGRRSTILVFSACCvatviAYLFLPL----GNAAMLVLGFPLGFFAAGIPASM 335
Cdd:cd17372 229 DVDYRDVFIATFaeFPGLLISAAMIDRLGRKASMASMLFTC-----CIFLLLLlicqSPFILTVLLFGGRACISAAFTVV 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 772975805 336 GALFNELYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGT 381
Cdd:cd17372 304 YIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLVHGSQTIA 349
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
25-401 |
1.20e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 77.98 E-value: 1.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 25 LDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQ 104
Cdd:cd17321 7 LAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 105 FVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYalafSLMPAALAWRVMFGVGLLPALL 184
Cdd:cd17321 87 LIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLG----GLLLELFGWRWIFLINVPIGLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 185 IVYVRRGIVepstdapktpaasqaaaaaplvgifaretlrmtlIGALLGVGAHGGYYALMTWLPTYLKVERHLSVLGTGG 264
Cdd:cd17321 163 ALLLARTFS----------------------------------GAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 265 YLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGN------AAMLVLGFPLGFFAAGIP-ASMGA 337
Cdd:cd17321 209 ALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSsvwlllPGLVLLGLGLGLFATPLTnAALSS 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 338 LfnelyPRGTRGTGVGFcYNFGRVASAGF------PVLVGHMSAGMPLGTAIGIDAAIAYSIVVAAVLML 401
Cdd:cd17321 289 V-----PKEKAGAASGI-LNTARQLGGALgvallgALLTAGLSANLGDSGVAALLSAAAAAFAAGFHLAF 352
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
17-411 |
1.89e-15 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 78.13 E-value: 1.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 17 WACFGGWALDALDVQMFSLVI--PAIIAEWSLSRTQAGFVGGAT---LVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSV 91
Cdd:TIGR00898 90 SDLGLAATEPCLDGWEYSYDTfsSTIVTEWDLVCEDAWKVDLTQscfFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAV 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 92 GTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSawavgwaaAVLLYALAFSLMPAAL-A 170
Cdd:TIGR00898 170 SGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQV--------FFSLGLVLLPLVAYFIpD 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 171 WRVMFGVGLLPALL------------------------IVYVRR-----GIVEPST--DAPKTPAASQAAAAAPLVGIFA 219
Cdd:TIGR00898 242 WRWLQLAVSLPTFLffllswfvpesprwlisqgrieeaLKILQRiakinGKKLPAEvlSLSLEKDLSSSKKQYSFLDLFR 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 220 RETLR-MTLIGALLGVGAHGGYYALMTwlptylkverHLSVLGTGGYLAVIIVAF--FCGCVASAHLLDRIGRRSTI--- 293
Cdd:TIGR00898 322 TPNLRkTTLCLMMLWFTTAFSYYGLVL----------DLGNLGGNIYLDLFISGLveLPAKLITLLLIDRLGRRYTMaas 391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 294 -LVFSACCVATviayLFLPLGNAAMLVLGFPLGFFAAGIPASMGALFN-ELYPRGTRGTGVGFCYNFGRVAS--AGFPVL 369
Cdd:TIGR00898 392 lLLAGVALLLL----LFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTaELYPTVVRNLGVGVCSTMARVGSiiSPFLVY 467
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 772975805 370 VGHMSAGMPLG--TAIGIDAAIaysivvaAVLMLPETRGRALDE 411
Cdd:TIGR00898 468 LGEKWLFLPLVlfGGLALLAGI-------LTLFLPETKGVPLPE 504
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
56-366 |
1.98e-15 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 77.41 E-value: 1.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 56 GATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSY-------PQFVIL-KTLQGLGFGGEWAAGAVLM 127
Cdd:cd17368 47 GVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYatigiaaPLLVLLaRLLQGFAAGGEVGGVTAYL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 128 AETIRAEHRGKAmGTVQSAWAVGWAAAVLLYALAFSL-MP----AALAWRVMFGVGLLPALLIVYVRRGIVE--PSTDAP 200
Cdd:cd17368 127 VEAAPPGRRGFY-TSWQSASQQVAIVAGALVGYLLSLtLTaealAEWGWRIPFFIGLLIIPLGLWLRRSLEEteAFLERK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 201 KTPAASqaaaaapLVGIFARETLRMTLIGALLGVGAHGGYYALMTWLPTYLKVERHLSVLGTGGYLAVIIVAFFCGCVAS 280
Cdd:cd17368 206 ARPTRR-------ELFALLANNRRIILLGMLLVAGSTVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 281 AHLLDRIGRRSTILVfSACCVATVIAYLFLPLGNA----AMLVLGFPLGFFAAGIPASMGALFNELYPRGTRGTGVGFCY 356
Cdd:cd17368 279 GALSDRIGRRPVLLV-ITLAALVTLYPVFAWLTAApsfgRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVY 357
|
330
....*....|
gi 772975805 357 NFGRVASAGF 366
Cdd:cd17368 358 ALAVAIFGGF 367
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
40-379 |
1.84e-14 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 74.15 E-value: 1.84e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 40 IIAEWSLSRTQAGFVGGAT---LVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGF 116
Cdd:cd17317 13 IVTEWDLVCDRDWLVALVQtifFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 117 GGEWAAGAVLMAETIRAEHRgKAMGTVQSAWAVGWAAAVLLYALAFSlmpaalAWRV-MFGVGLLPALLIVYVRRgivep 195
Cdd:cd17317 93 AGIFTVGFVLGMEIVGPKYR-SFVGILFGLFWALGYMLLALLAYLIR------DWRWlQLAISLPGLLFLLLLWW----- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 196 stdapktpaasqaaaaaplvgifareTLRMTLIGALLGVGAHGGYYALMtwlptylkveRHLSVLGTGGYLAVIIVAF-- 273
Cdd:cd17317 161 --------------------------LPRRTIIVGLIWFVTSLVYYGLS----------LNSSNLGGNLYLNFFLSGLve 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 274 FCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGIPASMGALF-NELYPRGTRGTGV 352
Cdd:cd17317 205 IPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYtAELYPTVVRNTGV 284
|
330 340
....*....|....*....|....*..
gi 772975805 353 GFCYNFGRVASAGFPVLVGHMSAGMPL 379
Cdd:cd17317 285 GLCSTVARVGAILAPFIVLLGKIGPLL 311
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
20-381 |
7.43e-14 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 72.41 E-value: 7.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 20 FGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFA 99
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 100 TSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMpaaLAWRVMF---- 175
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAEL---YSWHWVFivpg 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 176 GVGLLPALLIVYVRRG--------------IVEPSTDAPKTPAASQAAAaaplvgIFARETLRMTLIG--ALLGVGAHGG 239
Cdd:TIGR00881 158 IIAIIVSLICFLLLRDspqscglppaeempNEEPDGDAEKKEEELTKKQ------IFLQYVLLNKVLWyiSLGYVFVYVV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 240 YYALMTWLPTYLKVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRI--GRRSTILVFSACCV-ATVIAYLFLPLGNAA 316
Cdd:TIGR00881 232 RTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIiVSLLVYWLNPAANPL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 772975805 317 M-LVLGFPLGFFAAGIPASMGALFNELYPRGTRGTGVGFcynfgrvasAGFPVLVGHMSAGMPLGT 381
Cdd:TIGR00881 312 MdLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGF---------VGFFAYLGGILAGLPLGY 368
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
46-411 |
9.33e-14 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 72.69 E-value: 9.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 46 LSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFAT---SYPQFVILKTLQGLGFGGEWAA 122
Cdd:pfam00083 43 ALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 123 GAVLMAETIRAEHRGkAMGTVQSAWAVGWAAAVLLYALAFSLMPAALAWRVMFGVGLLPALLIVYVR------------R 190
Cdd:pfam00083 123 APMYISEIAPKKLRG-ALGSLYQLAITFGILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLlflpesprwlveK 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 191 GIVEPST----------------DAPKTPAASQAAAAAPLVGIFARETLRM--TLIGALLGVGAHGGYYALMTWLPTYLK 252
Cdd:pfam00083 202 GRLEEARevlaklrgvpdvdrelDEIKDSLEAGQEAEKASWKELFSTKTRRqrLLIGVMLQIFQQLTGINAIFYYSTTIF 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 253 VERHLS--VLGTGGYLAVIIVAFFCgcvaSAHLLDRIGRRSTILV--FSACCVATVIAYLFLPL-------GNAAMLVLG 321
Cdd:pfam00083 282 ENLGLSdsFLVTIIVGVVNFVFTFI----AIFLVDRFGRRPLLLLgaAGMAICFVILGIVALLGvsksdwaGIVAIVFIA 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 322 FPLGFFAAGIPASMGALFNELYPRGTRGTGVGFCYN----FGRVASAGFPVLVGHMSAGMplgtaIG-IDAAIAYSIVVA 396
Cdd:pfam00083 358 LFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAanwlANFLIGFLFPIITDAIGLGY-----TFfIFAGLLVLFIIF 432
|
410
....*....|....*
gi 772975805 397 AVLMLPETRGRALDE 411
Cdd:pfam00083 433 VFFFVPETKGRTLEE 447
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
23-331 |
1.57e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 71.45 E-value: 1.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 23 WALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSY 102
Cdd:cd17320 8 VALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 103 PQFVILKTLQGLGFggewAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMPAALAWR----VMFGVG 178
Cdd:cd17320 88 EQLLIARFLQGLGA----AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRaifvFLALLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 179 LLPALLIVYVRrgivePSTDAPKTPAASQAAAAAPLVGIFARetlRMTLIGALLGVGAHGGYYALMTWLPTYLKVERHLS 258
Cdd:cd17320 164 LLLLLLVLLFL-----PETLPEEKRKPLLSSLLRAYKRVLKN---RRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLS 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 772975805 259 VLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTI---LVFSACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGI 331
Cdd:cd17320 236 PAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLrlgLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGL 311
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
28-399 |
2.36e-13 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 71.23 E-value: 2.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 28 LDVQMFSLVIPAIIAEWSLSRTQAGFvgGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQ--- 104
Cdd:cd17366 21 LAVTIGKVFFPGGDPTAQLLATFATF--AVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTYATigv 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 105 -----FVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGK-----AMGTVQSAWAVGWAAAVLLYALAFSLMpAALAWRVM 174
Cdd:cd17366 99 wapilLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFlgswlEFGTLAGFILGAGLVTLLTLLLTEAQM-LDWGWRIP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 175 FGVGLLPALLIVYVRRGIvepstdapktpaasqaaaaaplvgifaretlrmtLIGALLGVGAHGGYYALMTWLPTYLKVE 254
Cdd:cd17366 178 FLIAAPLGLVGLYLRRPL----------------------------------LICIGLVLVFNVTNYMLLSYMPSYLEET 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 255 RHLS-----VLGTGGYLAVIIVAFFCGcvasaHLLDRIGRRSTILVFSACC-VATVIAYLFLPLGN-----AAMLVLGFP 323
Cdd:cd17366 224 LGYSethglLVIIIIMVTMLVLQPFLG-----RLSDRVGRKPVYAAGLAGLlVLAVPAFLLMNSGSiaaifIGLLVLGLL 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 772975805 324 LGFFAAGIPASMGALFnelyPRGTRGTGVGFCYNFGRVASAGFPVLVGHMsagmpLGTAIGIDAAIAYSIVVAAVL 399
Cdd:cd17366 299 LSCYTATMASTLPALF----PTHVRYSALAIAFNISVSLFGGTTPLVASW-----LVSATGNPLMPAYYLMVAAVV 365
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
37-372 |
3.35e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 70.73 E-value: 3.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 37 IPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGF 116
Cdd:cd17475 19 APFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 117 GGEWAAGAVLMAETIRAEHRGKAMGTVQSawavGWAAAVLLYALAFSLMPAALAWRVMFGV-GLLPALLIVYVRRGIVEP 195
Cdd:cd17475 99 GSVQPGGGRAIMRWFPPRERGLAMGIRQT----GVPLGGALAAALLPPLALHYGWRAAFVVaGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 196 STDAPKTPAASQAAAAAPLVgIFARETLRMTLIGALLGvgahGGYYALMTWLPTYLKVERHLSVLGTGGYLAVIIVAFFC 275
Cdd:cd17475 175 PAASAATESASTLLRSLKEV-LRNRDVWLIAIAGALLV----APQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 276 GCVASAHLLDRI--GRRSTILVFSAC-CVATVIAYLFLPLGNAAMLV--LGFPLGFFAAGIPASMGALFNELYPRGTRGT 350
Cdd:cd17475 250 GRIGLGRVSDRVfgGRRRPVLVITAAiAAAALLVLSLLSPGTPLWLLvlLLILLGLFAIGWNGLYLTLVAESAGPEQAGT 329
|
330 340
....*....|....*....|..
gi 772975805 351 GVGFCYNFGRVASAGFPVLVGH 372
Cdd:cd17475 330 ALGLANTINFIGIAIGPPLFGL 351
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
46-411 |
4.75e-13 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 70.12 E-value: 4.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 46 LSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAV 125
Cdd:cd17437 29 ISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 126 LMAETIRAEHRGkAMGTVQSAWAVGWAAAVLLYALAFSLMPAALAWRVMFGVGLLPALLIVYvrrGIvepsTDAPKTPAA 205
Cdd:cd17437 109 YTAEVAPASSRG-FLTSFPEIFINIGILLGYVSNYAFSGLPLHVGWRLMLGVGAVPSLFLAI---GV----LAMPESPRW 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 206 sqaaaaaplvgifaRETLRMTLIGALlgvGAH-----GGYYALMTWLPTYLK---VERHLSVLGTGGYLAVIIVAFFcgc 277
Cdd:cd17437 181 --------------TPAVRRMLIAAL---GIHffqqaSGIDAVVLYSPRIFKkagIKSKDKLLLATVAVGVTKTLFI--- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 278 VASAHLLDRIGRRSTIL------VFSACCVATVIAY-------LFLPLGNAAMLVLGFpLGFFAAGIPASMGALFNELYP 344
Cdd:cd17437 241 LVATFLLDKVGRRPLLLtstggmTLSLTALATSLTFidrngggLTWALVLAITAVCSF-VAFFSIGAGPITWVYSSEIFP 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 772975805 345 RGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIGIDAAIAYSIVVAAVLMLPETRGRALDE 411
Cdd:cd17437 320 LRLRAQGASLGVVVNRLMSGTVSMTFLSMSKAITTGGTFFLFAGVAAAAWVFFYFFLPETKGKSLEE 386
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
25-347 |
7.28e-13 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 69.53 E-value: 7.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 25 LDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQ 104
Cdd:cd17503 7 MAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 105 FVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWavgwaaavllyalafSLMPA-----------ALAWRV 173
Cdd:cd17503 87 LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVI---------------LLAPAigptlggwltdNLSWRW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 174 MFGVGLLPALLIVYvrrgivepstdapktpaasqaaaAAPLV--GIFARETLRmtlIGALLGVGAHGGYYALMTWLPTYL 251
Cdd:cd17503 152 IFYINLPIGILALL-----------------------LAPLLdlRLFKDRNFT---LGLLLSFLLGLGLFGAMFLLPLYL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 252 KVERHLSVLGTG-----GYLAVIIVAFFCGcvasaHLLDRIGRRSTILVfSACCVATVIAYLFLPLGNAAMLVLGFPLGF 326
Cdd:cd17503 206 QNVLGYSAFESGlvlapGGLASAILSPLVG-----RLLDKFGPRLLLLA-GLLLLALGTLLLAFLTPDTSLWLIILPLFI 279
|
330 340
....*....|....*....|....*....
gi 772975805 327 FAAGIP--------ASMGALFNELYPRGT 347
Cdd:cd17503 280 RGLGMGlvfmplntLALNSLPPEQIGDAT 308
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
32-390 |
1.25e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 68.74 E-value: 1.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 32 MFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTL 111
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 112 QGLGFGGEWAAGAVLMAETIRAEhRGKAMGTVQSawavgwaaavlLYALAFSLMPAALAW-------RVMFGVGLLPALL 184
Cdd:cd17478 94 AGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSV-----------GGNLGFALGPLIAAAlvalfggLGLLILLIIPGLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 185 IVYVRRGIVEPStdAPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVgahgGYYALMTWLPTYLkVERHLSVLGTGG 264
Cdd:cd17478 162 VALLLLRLRPLK--KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSW----VLSSLTTFLPFYL-VQRGYSLVFAGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 265 YLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLgnAAMLVLGFPLGFFAAGIPASMGALFNELYP 344
Cdd:cd17478 235 LLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPG--IWSYILLVLAGFLLFASFPVTVVLAQELLP 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 772975805 345 RGtRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIGIDAAIA 390
Cdd:cd17478 313 GN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLP 357
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
25-354 |
9.04e-12 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 66.05 E-value: 9.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 25 LDALDVQMFSLVIPAIIAEWSlSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQ 104
Cdd:cd17502 7 LAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTM 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 105 FVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGtVQSAWAVGWAAAVLLYALAFSlmpAALAWRVMFGVGlLPall 184
Cdd:cd17502 86 LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQG-YIGAVFGIASVAGPLIGGAFT---DHLSWRWCFYIN-LP--- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 185 ivyvrrgivepstdapktpaasqaaaaaplVGIFARETLRMTLIGALLGVGAHGGYYALMTWLPTYLKVERHLSVLGTGG 264
Cdd:cd17502 158 ------------------------------IGGLALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGV 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 265 YLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACC--VATVIAYLFLPLGNAAMLV-LGFPLGF-FAAGIPASMGALFN 340
Cdd:cd17502 208 RLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILmsVGAGLLTTLTLDTSKWLLIgYLILLGLgLGIGFQQPLVAVQN 287
|
330
....*....|....
gi 772975805 341 ELyPRGTRGTGVGF 354
Cdd:cd17502 288 AV-PPADVGVATAT 300
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
37-399 |
3.78e-11 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 64.26 E-value: 3.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 37 IPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGF 116
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 117 GGEWAAGAVLMAeTIRAEHRGKAMGTVQSAWAVGWAAAVLLYAlafSLMPAALAWRVMFGVGLLPALLIVYVRRGIVEPS 196
Cdd:cd17333 99 GILDTGANTFVG-ALFEESSATRLNVLHGFFGLGALIGPLIAT---SLLTSELSWSWAYLIIGLIYLLLAILILLTLFPE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 197 TDAPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVGAHGGYYalmTWLPTYLKVERHLSVLGTGGYLAVIIVAFFCG 276
Cdd:cd17333 175 LPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFS---SWVPSYLVEKKHVSDGLAGYLLSGFWVGITIG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 277 CVASAHLLDRIGrrSTILVFSACCVATVIAYLFLPLGN-AAMLVLGFPLGFFAAGIPASMGALFNELYPRGTrGTGVGFC 355
Cdd:cd17333 252 RLLGGPISRRIK--PHTLLVLSGSGALLGLLILLLAPTlVVGLVATALLGLFMAALFPTILSLGISNLPYAK-GKGTSVL 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 772975805 356 YNFGRVASAGFPVLVGHMSAGMPLGTAIGIDAAIAYSIVVAAVL 399
Cdd:cd17333 329 LAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
14-376 |
6.64e-11 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 63.45 E-value: 6.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 14 RTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRtlqwtiaFFSVGT 93
Cdd:cd17312 3 RIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRR-------FMSAGL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 94 FLCA-------FATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRgkamGTVQSAWAVGWAAAVLLYALAFSLMP 166
Cdd:cd17312 76 LLSAlanifmgFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKER----GTVYGIWSTSHNFGGILAPILAASLA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 167 AALAWRVMF----GVGLLPALLIVYVRRgivepstDAPktpaasqaaaaaPLVGIFARETLRMTLIgallgvgahggYYA 242
Cdd:cd17312 152 SYYGWRAAFlvpgIVGLVVAIILFFFLR-------DSP------------PYVWVLSLAYAFVYIV-----------RYA 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 243 LMTWLPTYLKVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRI--GRRSTILVFSAcCVATVIAYLFLPLGNAAML-- 318
Cdd:cd17312 202 CLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYM-LLMTLSLALFWFFPHNKLLsi 280
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 772975805 319 VLGFPLGFFAAGIPASMGALFNE-LYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAG 376
Cdd:cd17312 281 VLLFLIGFFVGGPINLIGGAAAQdIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDH 339
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
70-401 |
1.12e-10 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 62.62 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 70 GMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGfggewAAGAV---LMAETIRAEHRGKAMGTVqsa 146
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG-----AISSVvmaLLADLTREENRTKAMALI--- 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 147 wavgWAAAVLLYALAFSLMP---AALAWRVMF-GVGLLPALLIVYVrrGIVEPstDAPKTPAASQAAAAAPLVGIFARET 222
Cdd:cd17472 125 ----GASIGIAFAISMVLGPllaAHLGVSGLFlITAILSLVSLLIL--LFFVP--DPPKIVQISEKEKKKLKKLLKNKRL 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 223 LRMTLIGALLgvgaHGGYYALMTWLPTYLKVerhlSVLGTGG----YLAVIIVAFFCGcVASAHLLDRIGRRStiLVFSA 298
Cdd:cd17472 197 LRLDFSIFIL----HFVLMAFFYILPLLLTQ----LGGGKGQlwkvYLPAILIGFILM-VPFVIYAEKKGKMK--QVFVS 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 299 CCVATVIAYLFLPLGNAAMLVLGFPLGFFAAG---IPASMGALFNELYPRGTRGTGVGFCYNFGRVASAgfpvlVGHMSA 375
Cdd:cd17472 266 SILLIAVGFLLLLFAATSLWLLIIGLIIFFIGfnlLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSF-----LGGALG 340
|
330 340
....*....|....*....|....*.
gi 772975805 376 GMpLGTAIGIDAAIAYSIVVAAVLML 401
Cdd:cd17472 341 GL-LWGLLGYSSVFLTILILALLWLL 365
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
33-371 |
1.54e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 62.29 E-value: 1.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 33 FSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQ 112
Cdd:cd17355 22 FGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 113 GLGFGGEWAAGAVLMAETIR-AEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMPAALAWRVMFGVGLLPALLIVYVRRG 191
Cdd:cd17355 102 GGGGAGTLAAVAFATVAAWWfERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 192 IVEPSTDAPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVGAhggyYALMTWLPTYLkVERHLSVLGTGGYLAVIIV 271
Cdd:cd17355 182 RPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAV----VGLIVHLVPYL-ADRGISPAAAAVALALIGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 272 AFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGIPASMGALFNELYPRGTRGTG 351
Cdd:cd17355 257 FNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTL 336
|
330 340
....*....|....*....|
gi 772975805 352 VGFCYNFGRVASAGFPVLVG 371
Cdd:cd17355 337 FGLVFAPHQLGSALGPWLGG 356
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-145 |
3.49e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.44 E-value: 3.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 13 RRTFWACFGGWALDALDVQMFSLVIPAIIAE-WSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSV 91
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 772975805 92 GTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQS 145
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNT 331
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
31-401 |
5.00e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 60.69 E-value: 5.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 31 QMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKT 110
Cdd:cd17489 13 YLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 111 LQGLGFGGEWAAGAVLMAETIRAEHRGKAMGtvqsAWAVGWAAAVLLYALAFSLMPAALAWRVMFGVGLLPALLIVYVRR 190
Cdd:cd17489 93 IHGIGWGAFTTAAATLVADIIPPSRRGEGIG----YYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 191 GIvepsTDAPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVgahgGYYALMTWLPTYLkveRHLSVLGTGGYLAVII 270
Cdd:cd17489 169 LV----KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASI----AYGAISTFLPLYA---AERGISNAGLFFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 271 VAFFCGCVASAHLLDRIGRRsTILVFSACCVATVIAYLFLPLGNAAMLVLGFPLGF-FAAGIPAsMGALFNELYPRGTRG 349
Cdd:cd17489 238 IALLLSRPFSGKLSDRKGPK-TVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLgFGLLFPA-LQALAVDLVPPHRRG 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 772975805 350 TGVGFCYNFGRVASAGFPVLVGHMSAGMplgtaiGIDAAIAYSIVVAAVLML 401
Cdd:cd17489 316 AANGTFFIFFDLGIGLGGLLLGLVAELF------GYRAMFLLAAVVVLLALV 361
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
22-190 |
5.32e-10 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 60.75 E-value: 5.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 22 GWALDALDVQMFSLVIPAI-----IAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLC 96
Cdd:cd17364 7 GFFTDAYDLFSISLVTKILgrlyyGGKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 97 AFATSYPQFVILKTL------QGLGFGGEWAAGAVLMAETIRAEHRGK---------AMGTVQSAWAVGWAAAVLLYALA 161
Cdd:cd17364 87 ALSPGSTPLGVMGWLiffrflLGIGIGGDYPLSATIMSEYANKKRRGAliaavfamqGFGILAGAIVTLILSAIFEHPLP 166
|
170 180 190
....*....|....*....|....*....|
gi 772975805 162 FSLMPAA-LAWRVMFGVGLLPALLIVYVRR 190
Cdd:cd17364 167 AGTYHHAdLVWRIVLGLGAIPALSVLYFRK 196
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
32-401 |
1.39e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 59.51 E-value: 1.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 32 MFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTL 111
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 112 QGLGfGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYalafSLMPAALAWRVMFGVGLLPALLIVYVrrg 191
Cdd:cd17504 94 QGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLG----GWIVQHLGWRWIFWTAAPVAVLLAAL--- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 192 ivepstdapktpaasqaaaaAPLV--GIFARETLRMTLIGALL-GVGAHGGYYALMTWLPTYLKVERHLSVLGTGGYLAV 268
Cdd:cd17504 166 --------------------VPLIdlRLLRRRNVLLANITALLaGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 269 IIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGIPASMGALFNELYPRGTR 348
Cdd:cd17504 226 GALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRT 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 772975805 349 GTGVGFCYNFGRVASA-GFPVLVGHMSAGMPLGTAIGIDAAIAYS--IVVAAVLML 401
Cdd:cd17504 306 GIATGMNTVLRTIGSAiGPAIAGAILTTYTVSITSGGVPTEGAYVlaFLIGAALAL 361
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
15-368 |
1.64e-09 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 59.27 E-value: 1.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 15 TFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFgRVRTLqwtiafFSVGTF 94
Cdd:cd17343 4 IFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQI-SARWL------FSSGLV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 95 LCAFAT-------SYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHrgkaMGTVQSAWAVGWAAAVLLYALAFSLMPA 167
Cdd:cd17343 77 LSGLTTvafsgssSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQ----FGTWWSVLSTSMNLAGSLGPILATLLAL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 168 ALAWRVMF--------GVGLLPALLI------VYVRRGIVEPSTDAPKTPAASQAAAAAPLVGIFaretLRMTLIGALLG 233
Cdd:cd17343 153 SYGWRSTLsisgtvavVMSVVCLLFIknepsdVGLNNIEEEESKGKKKKSPRGESTLKELLLSPF----LWLLSLGYLVV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 234 VGAHggyYALMTWLPTYLKVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRST-----------ILVFSAccVA 302
Cdd:cd17343 229 FGVK---TAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGsssrgnprmplALVFMA--GL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 772975805 303 TVIAYLFLPL-----GNAAMLVLGFPLGFFAAGIPASMGALFNELYPRGTRGTG---VGFCYNFGRVAsAGFPV 368
Cdd:cd17343 304 TVSLHLFRVHitsdsSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTShaiVALAANVGGVL-AGLPF 376
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
57-354 |
2.17e-09 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 58.82 E-value: 2.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 57 ATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHR 136
Cdd:cd17360 43 STVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIR 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 137 GkAMGTVQSAWAVGWAAAVLLYALAFSLMPAalAWRVMFGVGLLPALLIVYVRRGIVEPstdaPKTPaasqaaaaaplvg 216
Cdd:cd17360 123 G-RLVTINVLFITGGQFVAYVINGAFSYLPG--GWRWMLGLAAVPAVLQFIGLLFLPES----PRWP------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 217 ifarETLRMTLIGALLGVGAH-GGYYALMTWLPTYLK---VERHLSVLGTGgylavIIVAF--FCGCVASAHLLDRIGRR 290
Cdd:cd17360 183 ----STRRALIVGCGLQAFQQfSGINTVMYYSATILQmagFKDNQNAIWLS-----LIVAGtnFIFTIVGMYLIDKFGRR 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 772975805 291 sTILVFSACCVATVIAYLFLPLgnaAMLVLGFPLGFFAAGIPASMGALFNELYPRGTRGTGVGF 354
Cdd:cd17360 254 -KLLLISLFGVIVALVVLAVWL---ALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGC 313
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
32-401 |
2.33e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 58.72 E-value: 2.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 32 MFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTL 111
Cdd:cd17477 14 LLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 112 QGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMPAALAwrVMFGVGLLPALLIVYVRRG 191
Cdd:cd17477 94 MGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFL--IAAVLLLLALVPLLLTRRA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 192 IVEPSTDAPKTPAASQAAAAAPLVGIFAretlrmtlIGALLGvgahggyyALMTWLPTYLkVERHLSVLGTGGYLAVIIV 271
Cdd:cd17477 172 APEIEEAESISLRRLLRIAPLALLGAFV--------AGFLEG--------AFYSLLPLYG-LRLGLSVAQAALLLAAFVL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 272 AFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGIPASMGALFNELYPRGTRGTG 351
Cdd:cd17477 235 GGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAA 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 772975805 352 ---VGFCYNFGRVASagfPVLVGhmsagmPLGTAIGIDAAIAYSIVVAAVLML 401
Cdd:cd17477 315 naaLLLLYGLGSVIG---PLLAG------ALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
46-411 |
1.74e-08 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 56.21 E-value: 1.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 46 LSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAV 125
Cdd:cd17362 36 LSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 126 LMAETIRAEHRGKamgTVQSAWAVGWAAAVLLYALAFSLMPAALAWRVMFGVGLLPALLIvyvrrgivepstdapktpaa 205
Cdd:cd17362 116 YIAETSPSHIRGL---LVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLL-------------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 206 SQAAAAAPLVGIFARETLRMTLIGALLGVGAH-GGYYALMTWLPTYLK-VERHLSVLGTGGYLAVIIVAFFCGCVASAhL 283
Cdd:cd17362 173 GIGMWFLPPSPRWQGNYRKPLIIGLGLVLFQQiTGQPSVLYYAATIFKsAGFSAASDATLVSVGLGVFKLLMTIVAVL-L 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 284 LDRIGRRSTIL----VFSACCVATVIAYLFLPLGNA-----AMLVLGFPLGFFAAGIPASMGALFNELYPRGTRGTGVGF 354
Cdd:cd17362 252 VDKLGRRPLLLggvsGMVVSLFLLAAYNLFVQMGPAglawlSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIAL 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 772975805 355 CYNFGRVASAGFPVLVGHMSAGMPLGTAIGIDAAIAYSIVVAAVLMLPETRGRALDE 411
Cdd:cd17362 332 AVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSLEE 388
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
26-137 |
4.38e-08 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 54.81 E-value: 4.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 26 DALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQF 105
Cdd:cd17442 13 EAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWF 92
|
90 100 110
....*....|....*....|....*....|..
gi 772975805 106 VILKTLQGLGFGGEwAAGAVLMAETIRAEHRG 137
Cdd:cd17442 93 VFLRCMVGCGVSGH-SQGLIIKTEFLPTKYRG 123
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
18-136 |
4.48e-08 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 54.66 E-value: 4.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 18 ACFGGWALDALD---VQMFSLVIPAiiaEWSLSRTQAGFVGGATlvasaIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTF 94
Cdd:cd17379 7 PCQDGWVYNTPRssiVTEFNLVCED---AWKLDLFQSSLNLGFL-----IGSIVIGYLADRFGRKVCFLISILGNGVSGV 78
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 772975805 95 LCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHR 136
Cdd:cd17379 79 LMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYR 120
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
46-411 |
5.28e-08 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 54.89 E-value: 5.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 46 LSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAV 125
Cdd:cd17358 38 LTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 126 LMAETIRAEHRGKAMGTVQsawavgwaAAVLLYALAFSLMPAALAWRVMFGVGLLPALLIV------------YVRRG-- 191
Cdd:cd17358 118 YIAEIAPKNVRGALGSLNQ--------LLVNIGILLGYVLGSFLPWRTLALIGAIPPVVFLillffipesprwLAKKGre 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 192 -----------------IVEPSTDAPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVGAH-GGYYALMTWLPTYLKv 253
Cdd:cd17358 190 eeaekslqflrgkdadiSKEAAEIQEELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQQlSGINAVIFYASSIFD- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 254 erhLSVLGTGGYLAVIIVAF--FCGCVASAHLLDRIGRRStILVFSA-----CCVATVIAYLFLPLGNAAMLVLGFPLG- 325
Cdd:cd17358 269 ---EAGSGLDPNTATIIIGVvqVVGTLVATLLVDRLGRRP-LLLVSAigmgiGLLALGLYFYLQEHGALLSSVSWLPLVg 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 326 --FFAAGIPASMGALF----NELYPRGTRGTGVG----FCYNFGRVASAGFPVLVGHMSAGmplGTAIgIDAAIAYSIVV 395
Cdd:cd17358 345 lvIYIISFSIGLGPLPwvimSEIFPAKIKGLAGSlvtlVNWLFAFIVTKTFPFLTLAWGAS---GTFW-IFAGICGLALV 420
|
410
....*....|....*.
gi 772975805 396 AAVLMLPETRGRALDE 411
Cdd:cd17358 421 FVLLFVPETKGKSLEE 436
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
45-411 |
7.59e-08 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 54.18 E-value: 7.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 45 SLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFL-CAFATSYPQFVILKTLQGLGFGGEWAAG 123
Cdd:cd17356 41 YPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIqVAAIGKWYQLIVGRIIAGLGVGFASVLV 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 124 AVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMPAAlAWRVMFGVGLLPALLIvyvrrgivepstdapktp 203
Cdd:cd17356 121 PVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDGSA-QWRIPLGLQIVWGLLL------------------ 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 204 aasqaaaaapLVGIFA-----RETLRMTLIGALLGVGAHGGYYALMTWLPTYLKVerhLSVLGTGGYLAVIIVAF--FCG 276
Cdd:cd17356 182 ----------LIGMFFlpespRWLYRTILGIMLQLFQQLTGINYFFYYGTTIFQS---TGLTGSSPLLTSIILYIvnFVS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 277 CVASAHLLDRIGRRSTIL---VFSACCVATVIAYLFLPL------------GNAAMLVLGFPLGFFAAGIPASMGALFN- 340
Cdd:cd17356 249 TIPGLFFVDKFGRRTCLLigaAGMSICLFIYAAVGVRYLipnpqsgtsnksAGNGMIVFICLFIFSFATTWGPIAWVYVa 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 772975805 341 ELYPRGTRGTGVGFCYNFGRVA----SAGFPVLVGHMSAGMPLgtaigIDAAIAYSIVVAAVLMLPETRGRALDE 411
Cdd:cd17356 329 EVFPLRVRSKGMALATAFNWLWnfliSFFTPFIIGSIGFKYYY-----IFAGCNLLAFIVVFFFVPETKGLTLEE 398
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
14-141 |
9.07e-08 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 53.92 E-value: 9.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 14 RTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGT 93
Cdd:TIGR00711 2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 772975805 94 FLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMG 141
Cdd:TIGR00711 82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMA 129
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
63-354 |
1.47e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.96 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 63 AIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGT 142
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 143 VQSawavgWAAAVLLYALAFSLMPAALAWRVMFGVGLLPALLIVYVRRGIVEPSTDAPKTPAASQAAAAAPLVGifaret 222
Cdd:cd17473 129 QSA-----AMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWK------ 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 223 lRMTLIGALLGVGAHgGYYALMTWLPTYLKVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACcva 302
Cdd:cd17473 198 -RVLPIYFLAFLAML-LFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFAL--- 272
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 772975805 303 TVIAYLFLPL-GNAAMLVLGFPLGFFAAGI--PASMGALFnELYPRGTRGTGVGF 354
Cdd:cd17473 273 MALGFLLLALaSGLWVVLLGAILAGLGFGLllPTLNSWAM-SLVPPELRGRAMGI 326
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
40-364 |
3.07e-07 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 51.91 E-value: 3.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 40 IIAEWSL--------SRTQAGFVGGATlvasaIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTL 111
Cdd:cd17374 23 IVTEWDLvcesqslkSVAQSIFMAGLL-----VGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 112 QGLGFGGEWAAGAVLMAETIRAEHRGKAMgtvqsawavgwaaavLLYALAFSLMPAALA--------WRVMFGVGLLPAL 183
Cdd:cd17374 98 AGFAVSGISINTLILGTEWTTPRHRALAI---------------TLTSCFFSIGQMLLAglayairdWRLLQLVVSVPFF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 184 LIVyvrrgivepstdapktpaasqaaaaaplvgIFARETLRMTLIGALLGVGAHGGYYALMTwlptylkverHLSVLGTG 263
Cdd:cd17374 163 LFF------------------------------LYSWWLPKRTLILSFVWFANSFSYYGLSL----------DLQHLGLN 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 264 GYL------AVIIVAFFCGCVasahLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGIPASMGA 337
Cdd:cd17374 203 VFLlqflfgAVEVPARCLALF----LLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTVLAVLGKGSSAAAFTISY 278
|
330 340
....*....|....*....|....*...
gi 772975805 338 LF-NELYPRGTRGTGVGFCYNFGRVASA 364
Cdd:cd17374 279 VYtAELFPTVLRQTGMGLNSMFARIGGI 306
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
46-401 |
3.35e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.21 E-value: 3.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 46 LSRTQAGFVGGATLVASAIGGWAAGMLSD----RFGRVRT-LQWTIAFFSVGTFLCAFATSYPQ------FVILKTLQGL 114
Cdd:COG2211 43 LSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPwILIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 115 GFGGEWAAGAVLMAE-TIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMP--AALAWRVMFGVGLLPALL-IVYVRR 190
Cdd:COG2211 123 AYTLVNIPYSALGAElTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGLLaFLLTFF 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 191 GIVEPSTDAPKTPAASQAaaaapLVGIFARETLRMTLIGALLGVGAhggYYALMTWLPTYLKVERHLSVLGTGGYLAVII 270
Cdd:COG2211 203 GTKERPVPEEEKVSLKES-----LKALLKNRPFLLLLLAYLLFFLA---LALVAALLLYYFKYVLGLSAALVGLLLALYF 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 271 VAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAMLVLGFPL-GFFAAGIPASMGALFNELYPR---- 345
Cdd:COG2211 275 LAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALaGIGLGAILVLPWAMLADVVDYdewk 354
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 772975805 346 -GTRGTGVGF-CYNFGRVASAGF-PVLVGHM--SAGMPLGTAIGIDAAIAYS---IVVAAVLML 401
Cdd:COG2211 355 tGRRREGLYFgIFTFAIKLGQALaGALAGLLlaLFGYVAGAAQSPSALTGIRllfFLLPAVLLL 418
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
14-138 |
3.61e-07 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 52.67 E-value: 3.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 14 RTFWACFG--GWALDALDVQMF--SLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFF 89
Cdd:TIGR01299 163 RFQWALFFvlGLALMADGVEVFvvGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVN 242
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 772975805 90 SVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGK 138
Cdd:TIGR01299 243 GFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGE 291
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
25-374 |
3.69e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.85 E-value: 3.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 25 LDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQ 104
Cdd:cd17328 10 LNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 105 FVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQsawAVGWAAAVLLYALAFSLMPAALAWRVMF-GVGLLPAL 183
Cdd:cd17328 90 LLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFY---FAIPLGSGLGYVVGGLVAQATGGWRWAFrVTGVLGVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 184 LIVYVRRGIVEPSTDAPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVGAHGGYYALMTWLPTYLKVERHLSVLGTG 263
Cdd:cd17328 167 LAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 264 ----GYLAVIIVAFFCGCVASAHLLDRIGRRS-----TILVFS--ACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGIP 332
Cdd:cd17328 247 dvglIFGAITCIAGVLGVLLGGILADRLRRKTpradpLVCAVGllAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNW 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 772975805 333 ASMGALFNELYPRGTRGTGVG----FCYNFGrvaSAGFPVLVGHMS 374
Cdd:cd17328 327 APVFAILLYVVIPTRRSTASAiqilLSHLLG---DAGSPYLIGLIS 369
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
16-400 |
4.75e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.46 E-value: 4.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 16 FWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFL 95
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 96 CAFAT-----SYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMPAALA 170
Cdd:cd06173 81 LALLAllgslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 171 WRVMFGVGLLPALLIVYVRRGIVEPSTDAPKTPAASQAAAaapLVGIFARETLRMTLIGALLGVGAHGGYYALmtwLPTY 250
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREG---LRYLRRSPLLRLLLLALALFALLGGALTVL---LPLL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 251 LKVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGnAAMLVLGFPLGFFAAG 330
Cdd:cd06173 235 AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL-WLLLAALFLLGLAGGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 331 IPASMGALFNELYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIGIDAAIAYSIVVAAVLM 400
Cdd:cd06173 314 FNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
26-138 |
5.21e-07 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 51.85 E-value: 5.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 26 DALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQF 105
Cdd:cd17438 11 DGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAF 90
|
90 100 110
....*....|....*....|....*....|...
gi 772975805 106 VILKTLQGLGFGGEWAAGAVLMAETIRAEHRGK 138
Cdd:cd17438 91 LFCRLISGFGIGGSLPIVFAYFSEFLAREKRGE 123
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
32-141 |
9.74e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 50.65 E-value: 9.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 32 MFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTL 111
Cdd:cd17323 17 IYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFL 96
|
90 100 110
....*....|....*....|....*....|
gi 772975805 112 QGLGFGGEWAAGAVLMAETIRAEHRGKAMG 141
Cdd:cd17323 97 QGFFGSSPLAIGAGTIADLFTPEERGKAMG 126
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
40-381 |
1.08e-06 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 50.44 E-value: 1.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 40 IIAEWSL---SRTQAGFVGGATLVASAIGGWAAGMLSD-RFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLG 115
Cdd:cd17378 21 IVSEWGLicaGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 116 FGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSlmpaalAWRVMFGVGLLPALLIVYvrrgivep 195
Cdd:cd17378 101 RSGIGTCALVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAYLNGS------SWRVLYFWTSIPALIYCI-------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 196 stdapktpaasqaaaaapLVGIFARETLRMTLIGALLGVgahggyyalmtwlpTYLKVERHLSVLGTGGYLAVIIVAF-- 273
Cdd:cd17378 167 ------------------LVYLFARRLLAVMVIGFGIGM--------------VYYGIPLAVGNLKFNIYLSVALNALse 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 274 FCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPLGNAAMLVLGFPL-GFFAAGIPASMGALF-NELYPRGTRGTG 351
Cdd:cd17378 215 LPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTSLQIALELvGFFGAAGAFNLLYIYtVELFPTCVRNAA 294
|
330 340 350
....*....|....*....|....*....|..
gi 772975805 352 VGFCYNFGRVASAGFPVLV--GHMSAGMPLGT 381
Cdd:cd17378 295 LGMLRQALVVGGIFAPFIVslGRKNAALSFGV 326
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
23-363 |
1.59e-06 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 49.81 E-value: 1.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 23 WALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSY 102
Cdd:cd17441 8 WMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 103 PQFVILKTLQGLGFGGEwAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALafsLMPaALAWRVMFGVGLLPA 182
Cdd:cd17441 88 SWILVLRGLVGFGIGGV-PQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVF---VMP-TLGWRWLLILSALPL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 183 LLIVYVRRGIVEPstdapktpaasqaaaaaplvgifARetLRMTLIGALLGVGAHGGYYALMTwLPTYLKVERHLSVLGT 262
Cdd:cd17441 163 LIFAVLCFWLPES-----------------------AR--YWTTILLWFIWFSNAFSYYGLVL-LTTELFQAGDVCSGSS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 263 GGY-------------------LAVIIVAFFCGCVASAHLLDRIGRRSTI----LVFSACCVAtviayLFLPLGNAAMLV 319
Cdd:cd17441 217 GKKvegkcsleceylttsdymdLLWTTLSEFPGLLVTLWIIDRFGRKKTMalcfFVFSFCTLL-----LFSCVGRFSLTV 291
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 772975805 320 LGFPLGFFAAGIPASMGALFNELYPRGTRGTGVGFCYNFGRVAS 363
Cdd:cd17441 292 LLFIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGA 335
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
22-140 |
2.54e-06 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 49.64 E-value: 2.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 22 GWALDALDVQMF--SLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFA 99
Cdd:cd17439 5 GLALMADGVEVFvvGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFV 84
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 772975805 100 TSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAM 140
Cdd:cd17439 85 QGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHL 125
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
22-138 |
3.25e-06 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 49.02 E-value: 3.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 22 GWALDALDVQMF--SLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFA 99
Cdd:cd17363 5 GLALMADGVEVFvvGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFV 84
|
90 100 110
....*....|....*....|....*....|....*....
gi 772975805 100 TSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGK 138
Cdd:cd17363 85 QGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGE 123
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
64-339 |
5.03e-06 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 48.55 E-value: 5.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 64 IGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQ--------FVILKTLQGLGFGGEWAAGAVLMAETIRAEH 135
Cdd:PRK10642 72 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYATigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 136 RGkAMGtvqSAWAVGWAAAVLLYALAFSLMPAAL--------AWRVMFGVGLLPALLIVYVRRGIVEPST---------- 197
Cdd:PRK10642 152 RG-FMG---SWLDFGSIAGFVLGAGVVVLISTIVgeanfldwGWRIPFFIALPLGIIGLYLRHALEETPAfqqhvdkleq 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 198 -------DAPKTPAASqaaaaaplvgiFARETLRMTLIGALLGVGAHGGYYALMTWLPTYLKVERHLSvlgtGGYLAVII 270
Cdd:PRK10642 228 gdreglqDGPKVSFKE-----------IATKHWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYS----EDHGVLII 292
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 772975805 271 VAFFCGCV----ASAHLLDRIGRRSTILVFSACCVATVI-AYLFLPLGN-----AAMLVLGFPLGFFAAGIPASMGALF 339
Cdd:PRK10642 293 IAIMIGMLfvqpVMGLLSDRFGRRPFVILGSVALFVLAIpAFILINSNViglifAGLLMLAVILNCFTGVMASTLPAMF 371
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
45-139 |
7.20e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 47.99 E-value: 7.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 45 SLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGA 124
Cdd:cd17329 31 GLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASE 110
|
90
....*....|....*
gi 772975805 125 VLMAETIRAEHRGKA 139
Cdd:cd17329 111 AMIADVTTPENRTRA 125
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
32-400 |
8.45e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 47.63 E-value: 8.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 32 MFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFA-TSYPQFVILKT 110
Cdd:cd17341 17 LFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLGF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 111 LQGLGfGGEWAAGAVLMAETIRAEHRGKAMGTVQSAW---AVGWAAAVLLYALAFSLMPAALAWRVMFGVGLLPALL--I 185
Cdd:cd17341 97 LLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGnmgVAVSQLLAPLIAGAIVFDGGFVGWRNAFFVPGILLAIaaV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 186 VYVRRGIvepstDAPKTPAASQAAAAAPLVGIFARETLRMtligALLGVGAHGGYYALMTWLPTYLKVERHLSVLGTGGY 265
Cdd:cd17341 176 LVLLFGD-----DLPTGKASALEFLKVQLAVLKNYRTWIL----SLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGIL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 266 LAVIIVAFFCGCVASAHLLDRIG-RRSTILVFSACCVATVIAYLFLPLGNAAM---LVLGFPLGFFAAGIPASMGALFNE 341
Cdd:cd17341 247 AALFPLAGALARPAGGWLSDRFGgRRRLWWLFIVMTIGAALLSLSLPTSGTNLvlfLALFVALGLGAGAGNGSVFRMVPF 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 772975805 342 LYPRGTrGTGVGFCYNFGRVASAGFPVLVGhMSAGMPLGTAIGIdAAIAYSIVVAAVLM 400
Cdd:cd17341 327 IFRREL-GAVTGLVGAIGGLGGFFLPLLFG-SSALMTGSGVGAF-SLFGVLAVACTLLV 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
230-419 |
1.08e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.03 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 230 ALLGVGAHGGYYALMTWLPTYLKVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRsTILVFSACCVATVIAYLF 309
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRR-RVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 310 LPLGNAAMLVLGFPLGFFAAGIPASMGALFNELYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIGIDAAI 389
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190
....*....|....*....|....*....|
gi 772975805 390 AYSIVVAAVLMLPETRGRALDEGADADART 419
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSL 190
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
47-145 |
1.09e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 47 SRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVL 126
Cdd:cd17473 231 SAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSW 310
|
90
....*....|....*....
gi 772975805 127 MAETIRAEHRGKAMGTVQS 145
Cdd:cd17473 311 AMSLVPPELRGRAMGIVTS 329
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
50-366 |
1.12e-05 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 47.50 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 50 QAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSY-------PQFVILKTL-QGLGFGGEWA 121
Cdd:PRK10406 64 QTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYetigtwaPALLLLARLfQGLSVGGEYG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 122 AGAVLMAEtIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFS--LMPAAL---AWRVMFGVGLLPALLIVYVRRGIVEPS 196
Cdd:PRK10406 144 TSATYMSE-VAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQqtLEDAELrewGWRIPFALGAVLAVVALWLRRQLDETS 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 197 TDAPKtpaasQAAAAAPLVGIFA-RETLRMtligaLLGVGAHGG--YYALMTWLPTYLKVERHLSVLGTGGYLAVIIVAF 273
Cdd:PRK10406 223 QQETR-----ALKEAGSLKGLWRnRRAFIM-----VLGFTAAGSlcFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVF 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 274 FCGCVASAHLLDRIGRRSTILVFSACC------VATVIAYLFLPLGNAAMLVLGFPLGFFAAGIPasmGALFNELYPRGT 347
Cdd:PRK10406 293 MLIQPLIGALSDKIGRRTSMLCFGSLAalftvpILSALQNVSSPYAAFGLVMCALLIVSFYTSIS---GILKAEMFPAQV 369
|
330
....*....|....*....
gi 772975805 348 RGTGVGFCYnfgRVASAGF 366
Cdd:PRK10406 370 RALGVGLSY---AVANALF 385
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
25-389 |
1.77e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 46.61 E-value: 1.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 25 LDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQ 104
Cdd:TIGR00710 16 LGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIET 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 105 FVILKTLQGLGFggewAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMPAALAWRVMFGV----GLL 180
Cdd:TIGR00710 96 LLVLRFVQAFGA----SAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFlslaGIL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 181 PALLIVYVRrgivepstdaPKTPAASQAAAAAPLVGIFARETLRMTLIGALLGVGA-HGGYYALMTWLPTYLKVERHLSV 259
Cdd:TIGR00710 172 LSALIFFIL----------PETLPYEARIQISTYFETFLLLLKSKMFWGYALIYGAsFGGFFAFFSGAPFVYIDIMGVSP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 260 LGTGGYLAVIIVAFFCGCVASAHLLDRIG----RRSTILVFSACCVATVIAyLFLPLGNAAMLVLgfPLGFFAAGIPASM 335
Cdd:TIGR00710 242 SVFGLLFALNIIAMIFGGFLNGRFIKKWGakslLRMGLILFAVSAVLLEIT-AILGLGSWAMIIG--PMMFVGIGNSMIS 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 772975805 336 GALFN---ELYPRGT-RGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIGIDAAI 389
Cdd:TIGR00710 319 SIAMAyalEDFPHVAgTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVV 376
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
46-141 |
1.99e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 46.68 E-value: 1.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 46 LSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAV 125
Cdd:COG2270 271 FSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRS 350
|
90
....*....|....*.
gi 772975805 126 LMAETIRAEHRGKAMG 141
Cdd:COG2270 351 LLARLIPPGREAEFFG 366
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
271-409 |
2.10e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 46.89 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 271 VAFFCGCVASAHLLDRIGRrstILVFSACCVATVIAYLFLPLGNAAMLVLGFPLGFFAAGIPA--SMGALFNELYPRGTR 348
Cdd:TIGR01299 606 LAVLPGNIVSALLMDKIGR---LRMLAGSMVLSCISCFFLSFGNSESAMIALLCLFGGLSIAAwnALDVLTVELYPSDKR 682
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 772975805 349 GTGVGFCYNFGRVAS----AGFPVLVGhMSAGMPLGTAigiDAAIAYSIVVAavLMLPETRGRAL 409
Cdd:TIGR01299 683 ATAFGFLNALCKAAAvlgiLIFGSFVG-ITKAAPILFA---SAALACGGLLA--LKLPDTRGQVL 741
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
51-144 |
2.50e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.10 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 51 AGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLgFGGEWAAGAVLMAET 130
Cdd:cd17391 38 SGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FSGYVPNATALIASQ 116
|
90
....*....|....
gi 772975805 131 IRAEHRGKAMGTVQ 144
Cdd:cd17391 117 TPKEKSGWALGTLS 130
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
19-294 |
2.54e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 46.01 E-value: 2.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 19 CFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLC-- 96
Cdd:cd17380 4 LFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTpl 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 97 AFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYalafSLMPAALAWRVMFG 176
Cdd:cd17380 84 LAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIG----PLLLEYYGWPSVFY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 177 VGLLPALLIVYVRRgIVEPSTDApktpaasqaaaaaPLVGIFAretlrmtligallgvgAHGGYYALMTWLPTYLKveRH 256
Cdd:cd17380 160 FFGLLGLLWALVWL-IYLPPVWA-------------IIVAHFC----------------MNWGFYILLSWLPTYFH--EV 207
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 772975805 257 LSVLGTGGYLAVI--IVAFFCGcVASAHLLDR-IGRRSTIL 294
Cdd:cd17380 208 LVPLAKGWVFNVVpwLVMFPSS-NVAGWLADHlISRGWTVT 247
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
32-131 |
8.21e-05 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 44.51 E-value: 8.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 32 MFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTL 111
Cdd:PRK11652 26 IYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAI 105
|
90 100
....*....|....*....|
gi 772975805 112 QGLGFGgewAAGAvlMAETI 131
Cdd:PRK11652 106 QGLGTG---VGGV--MARTL 120
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
24-143 |
1.02e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.11 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 24 ALDALDVQMFSLVIPAIIAEW---SLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFAT 100
Cdd:cd17330 6 FLDALGFGIVFPVLPFYVREFnklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR 85
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 772975805 101 SYPQFVILKTLQGLGFGGEWAAGAVLmAETIRAEHRGKAMGTV 143
Cdd:cd17330 86 NLWLLFLARFLDGLTGGNVSVAQAYI-ADITDEEERAKAFGII 127
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
33-400 |
1.99e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 43.38 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 33 FSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRtlqwtiaFFSVGTFLCAFA-----------TS 101
Cdd:cd17345 22 FSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKR-------FLAIGLILSAIIniligfvpsatSS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 102 YPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMG---TVQSAWAVGWAAAVLLYALAFslmpAALAWRVMFG-- 176
Cdd:cd17345 95 VGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSiwnISHNVGGGLVGPLAGLGLAIF----GDGWWRGAFIfp 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 177 --VGLLPALLIVYVRRG---------IVEPSTDAPKTPAASQAAAAAPLVGIFARETLRMTLIG--ALLGVGAHGGYYAL 243
Cdd:cd17345 171 aiIAIIVAVIVLFLGKDtpeseglppIEEYKGDYPEEADGEEEEQELSAWEIFVKYVLKNKLLWyiAIANVFVYLVRYGI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 244 MTWLPTYLKVERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRI--GRRS-TILVFSACCVATVIAYLFLPLGNAAMLVL 320
Cdd:cd17345 251 LDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLfkGRRApTGIIFMILVIVALIVYWLAPNVLVDLIAL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 321 GFpLGFFAAGIPASMGALFNELYPRGTRGTGVGFC----YNFGRV-ASAGFPVLVGHMSAGmplGTAIGIDAAIAYSIVV 395
Cdd:cd17345 331 IA-LGFLIYGPVMLIGLQALELVPKKAAGTAAGLTglfgYLGGSVlATALIGIIVDHFGWN---GGFIVLLASCILAIIF 406
|
....*
gi 772975805 396 AAVLM 400
Cdd:cd17345 407 LALVA 411
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
22-138 |
2.09e-04 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 43.36 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 22 GWALDALDVQMF--SLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFA 99
Cdd:cd17440 5 GMALMADGVEVFvvGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFV 84
|
90 100 110
....*....|....*....|....*....|....*....
gi 772975805 100 TSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGK 138
Cdd:cd17440 85 QGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGE 123
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
271-405 |
2.30e-04 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 43.36 E-value: 2.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 271 VAFFCGCVASAHLLDRIGRRsTILVFSAccVATVIAYLFLPLGNAAMLVLGFPLGFFAAGIPA--SMGALFNELYPRGTR 348
Cdd:cd17440 348 LAVLPGNIVSALLMDRIGRL-TMLGGSM--VLSGISCFFLWFGTSESMMIGMLCLYNGLTISAwnSLDVVTVELYPTDRR 424
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 349 GTGVGFCYNFGRVASagfpvLVGHMSAGMPLGTAIGIDAAIAYSIVVAAVLM---LPETR 405
Cdd:cd17440 425 ATGFGFLNALCKAAA-----VLGNLIFGSLVGITKAIPILLASTVLVCGGLVglrLPDTR 479
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
31-401 |
2.59e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 31 QMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQW---TIAFFSVGTFlcAFATSYPQFVI 107
Cdd:cd17370 16 EMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVIlgyGLSALAKPLL--ALAGSWQLVLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 108 LKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLmpAALAWRVMFGVGLLPALLIVY 187
Cdd:cd17370 94 LRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYL--LGGNYRTIFLLAAIPALLALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 188 VRRGIVEPSTDAPKTPAASQAAAAAPLVGIFaretLRMTLIGALLGVG-AHGGYYALMTwlptylkVERHLSVLGTGGYL 266
Cdd:cd17370 172 ILLFVVKEYPRPPKLRKKSKKTSLKKLPKAF----WLYLLAVALFALGnFSFAFLILRA-------QELGLSAALIPLLY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 267 AVIIVAFFCGCVASAHLLDRIGRRSTILVFsacCVATVIAYL-FLPLGNAAMLVLGFPL-GFFAAGIPASMGALFNELYP 344
Cdd:cd17370 241 ALFNLVYALAAYPAGRLSDRIGRKKLLILG---YLSLALAYLgFALGSSLWLLLLGFILwGLYMGAQESIERAAVADLVP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 772975805 345 RGTRGTGVGFcYNFGRvasaGFPVLVGHMSAGMpLGTAIGIDAAIAYSIVVAAVLML 401
Cdd:cd17370 318 AELRGTAYGL-FNTVV----GIGWLLASLIAGY-LWDLISPSAAFLFSAVLALIALL 368
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
33-403 |
2.72e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 43.06 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 33 FSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQ 112
Cdd:cd06180 18 YTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 113 GLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSL-MPAALAWRVMFGVGLLPALLIVYVRRG 191
Cdd:cd06180 98 GAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGgLSWRAGWLALALLSAVLLLLSFLLLRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 192 IVEPSTDAPktpaasqaaaaaplvGIFARETLRMTLIGALLGVGAHG-GYYALMTWLPTYLKvERHLSVLGTGGYLAVII 270
Cdd:cd06180 178 GPSAPTEAS---------------AAESAPGLNRPLWRLALAYGLFGfGYIITATFLPLIAR-ETGAGSLLAGLLWSLFG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 271 VAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPlGNAAMLVLGFPLGFFAAGIPASMGALFNELYPRGTRGT 350
Cdd:cd06180 242 LAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSP-GPAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 772975805 351 --GVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIGidaaiAYSIVVAAVLMLPE 403
Cdd:cd06180 321 laLMTASFGVGQILGPLLAGWLADATGGFAPALILA-----AAALVVAALLALLV 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
219-408 |
3.01e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.65 E-value: 3.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 219 ARETLRMTLIGALLGVGAHGGYYALMTWLPTYLKvERHLSVLGTGGYLAVIIVAFFCGCVASAHLLDRIGRRSTILVFSA 298
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 299 CCVATVIAYLFLPlgNAAMLVLG-FPLGFFAAGIPASMGALFNELYPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGM 377
Cdd:COG2814 84 LFALGSLLCALAP--SLWLLLAArFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190
....*....|....*....|....*....|.
gi 772975805 378 PLGTAIGIDAAIAYSIVVAAVLMLPETRGRA 408
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAA 192
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-131 |
3.20e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.97 E-value: 3.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 14 RTFWACFGGWALDALDVQMF-SLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVG 92
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVaALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 772975805 93 TFLCAFA--TSYPQFVILKTLQGLGFGGEWAAGAVLMAETI 131
Cdd:COG2211 308 LLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVV 348
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
42-117 |
4.01e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 42.23 E-value: 4.01e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 772975805 42 AEWSLSRTQAGFVGGATLvasaigGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFG 117
Cdd:PRK15402 47 AEWVPTSMTAYLAGGMFL------QWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLC 116
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
18-143 |
4.46e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 42.61 E-value: 4.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 18 ACFGGWALDALDVQMFSLVIPAIIAEWsLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCA 97
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADL-GPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 772975805 98 FATSYPQFVILKTLQGLGFGGEWAAGAVlMAETIRAEHRGKAMGTV 143
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAGTQGLGAAV-ASELVPNKYRGLVQGVV 125
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
19-136 |
5.95e-04 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 41.64 E-value: 5.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 19 CFGGWALDAldvqmfSLVIPAIIAEWSLSRTQAGFVGGAT---LVASAIGGWAAGMLSDRFGRVRTLQwtIAFFSVGTF- 94
Cdd:cd17447 8 CQNGWVYDH------STFSSTIATEWDLVCDRKGLNQATAtffFAGVTMGAVAFGYLSDRFGRKRMLL--VAYVLSLVFg 79
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 772975805 95 -LCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHR 136
Cdd:cd17447 80 lASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHR 122
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
40-118 |
2.05e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 40.09 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 40 IIAEWSL---SRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGF 116
Cdd:cd17446 21 IITEWDLvcnHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMAL 100
|
..
gi 772975805 117 GG 118
Cdd:cd17446 101 SG 102
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
14-331 |
2.63e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 39.59 E-value: 2.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 14 RTFWACFGGWALDALDVQMFSLVIPAIIAE-WSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVG 92
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSPLAVFLIKDdLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 93 TFLCAFAT-SYPQFVILKTLQGLGfGGEWAAGAVLMAETIRAEHRGKAM------GTVQSAWAVGWAAAVLLYALAFSLM 165
Cdd:TIGR00886 81 CLWAGLAVqSYSVLLLIRLFIGIA-GGSFASCMPWISFFFPKKIQGTALglaagwGNMGGGVAQFVMPPIIGSLIFGGGQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 166 PAALAWRVMFGVG-----LLPALLIVYVRrgivepSTDAPKTPAASQAAAAAPLVGIFARETLRMtligALLGVGAHGGY 240
Cdd:TIGR00886 160 PAHLAWGWAFVIVpagilLLPALLIFFVG------ADTPPGKPATGKLSFKEALKVFGNRHTWIL----ALLYSVTFGSF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 241 YALMTWLPTYLKVERHLSVLGTGGYlaviivAFFCGCV------ASAHLLDRIGRRsTILVFSACCVATVIAYLFL---P 311
Cdd:TIGR00886 230 LGVSSIFAMLFKDQFGLSKVQAGAY------ASLGGFLgslarpAGGAISDRLGGA-RKLLMNFLGVAMGAFLVVLglvS 302
|
330 340
....*....|....*....|
gi 772975805 312 LGNAAMLVLGFPLGFFAAGI 331
Cdd:TIGR00886 303 DGSLAAFIVLFVALFFFAGA 322
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
13-185 |
2.88e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.51 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 13 RRTFWACFGGWALDALDVQMFSLVIPAIIAEW-SLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSV 91
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 92 GTFLCAFATSYPQFVILKTLQGLGF--GGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMPAAL 169
Cdd:cd17316 256 LALPLFYLLSGSPTLLLLLLFILSFfvGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335
|
170
....*....|....*.
gi 772975805 170 AWRVMFGVGLLPALLI 185
Cdd:cd17316 336 VPALILALLAIVALIV 351
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-145 |
2.91e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.72 E-value: 2.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 11 RERRTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWT-IAFF 89
Cdd:cd06174 201 KNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIgLLLM 280
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 772975805 90 SVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQS 145
Cdd:cd06174 281 ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNT 336
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
5-145 |
2.96e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 5 FGAISARERRTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQW 84
Cdd:pfam07690 191 IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 772975805 85 TIAFFSVGT---FLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTVQS 145
Cdd:pfam07690 271 ALLLLILAAlglLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNT 334
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
17-400 |
3.51e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.55 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 17 WACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLC 96
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 97 AFATSYPQFVILKTLqglgFGGEWAAGAVLM-AETIRAEhrgKAMG-TVQSAWAVGWAAAVLLYALAFSLMPAAL--AWR 172
Cdd:cd17393 82 GLAPSVPALALALFL----FGAANGALDVAMnAQGVAVE---RAYGrPIMSSLHAMWSLGGLAGALLGAAAIGAGvsPGV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 173 VMFGVGLLPALLIVYVRRGIVEPSTDAPKTPAASQAAAAAplvgifaRETLRMTLIGALLGVGAHGGYYALMTWLPTYLK 252
Cdd:cd17393 155 HLLAAAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPGF-------LLPNRLLLLLGLLALAAALAEGAAADWSALYLR 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 253 VERHLSV-LGTGGYlAVIIVAFFCGCVASAHLLDRIGRRSTILVFSACCVATVIAYLFLPlgNAAMLVLGFPL-GF-FAA 329
Cdd:cd17393 228 DVLGASAaLAALGY-AVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAP--SVWVALAGFALmGLgLSV 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 772975805 330 GIPASMGALFNElyPRGTRGTGVGFCYNFGRVASAGFPVLVGHMSAGMPLGTAIGIDAAIAYSIVVAAVLM 400
Cdd:cd17393 305 VVPLAFSAAGAL--PGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLARAV 373
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-143 |
4.54e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.18 E-value: 4.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 13 RRTFWACFGGWALDALDVQMFSLVIPAIIAEWSLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVG 92
Cdd:cd17355 209 SASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALG 288
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 772975805 93 TFLCAFATSYPQFVIlktLQGLGFGGEWAAGAVLMAETIRAEHRGKAMGTV 143
Cdd:cd17355 289 LALLLLLPFPPLALL---LFAALFGLGWGATVPLTAALAARYFGARSYGTL 336
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
51-145 |
5.25e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.78 E-value: 5.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 51 AGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGAVLMAET 130
Cdd:cd17391 242 SGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKI 321
|
90
....*....|....*
gi 772975805 131 IRAEHRGKAMGTVQS 145
Cdd:cd17391 322 TPKEVAGRIFGYNQS 336
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
59-115 |
7.87e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 38.33 E-value: 7.87e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 772975805 59 LVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLG 115
Cdd:PRK11043 51 LAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVG 107
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
52-184 |
9.07e-03 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 38.14 E-value: 9.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 52 GFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFsvgtFLCAFATSYP----------------QFVILKTLQGLG 115
Cdd:PRK10077 58 GFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLF----FISALGSAWPefgftsigpdntgyvpEFVIYRIIGGIG 133
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 772975805 116 FGGEWAAGAVLMAETIRAEHRGKAMGTVQSAWAVGWAAAVLLYALAFSLMPAA----LAWRVMFGVGLLPALL 184
Cdd:PRK10077 134 VGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFIARSGDASwlntDGWRYMFASEAIPALL 206
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
45-411 |
9.07e-03 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 38.24 E-value: 9.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 45 SLSRTQAGFVGGATLVASAIGGWAAGMLSDRFGRVRTLQWTIAFFSVGTFLCAFATSYPQFVILKTLQGLGFGGEWAAGA 124
Cdd:cd17435 32 ALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATC 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 125 VLMAETIRAEHRGKAMgTVQSAWAVGWAAAVLLYALAFSLMPAalAWRVMFGVGLLPALLivyvrRGIVEPSTdaPKTPA 204
Cdd:cd17435 112 VYIAEIAPQHRRGLLV-SLNELMIVIGILLAYISNYAFANVSN--GWKYMFGLVIPLAAL-----QAIAMYFL--PPSPR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 205 AsqaaaaaplvgIFARETLRM-TLIGALLGVGAH-GGYYALMTWLPTYLKV----ERHLSVLGTGGYLAVIIVaffcGCV 278
Cdd:cd17435 182 F-----------LVMKDNMRArLLIGLTLVFFVQiTGQPNILFYASTVLKSvgfqSNEAASLASTGVGVVKVV----STI 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772975805 279 ASAHLLDRIGRRSTILVFSAC-CVATVIAYLFLPLGNAAMLVLGFPLGFfaagipASMGAL-FNELYPRGTRGTGVGF-- 354
Cdd:cd17435 247 PAIFLVDKVGSKTFLCIGSSVmAVSLVTMGLWLSLASLLVYVAAFSIGL------GPMPWLvLSEIFPGGIRGRAMALts 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 772975805 355 CYNFGRVASAGFPVLVGHMSAGMPlgTAIGIDAAIAYSIVVAAVLMLPETRGRALDE 411
Cdd:cd17435 321 SMNWGINLLISLTFLTVTELIGLP--WVCFIYTAMSLASLVFVIMFVPETKGCSLEQ 375
|
|
| |
