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Conserved domains on  [gi|772242060|gb|AJW77602|]
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poly(R)-hydroxyalkanoic acid synthase, partial [Halobacterium jilantaiense]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PhaC super family cl43819
Poly-beta-hydroxybutyrate synthase [Lipid transport and metabolism];
2-100 8.02e-44

Poly-beta-hydroxybutyrate synthase [Lipid transport and metabolism];


The actual alignment was detected with superfamily member COG3243:

Pssm-ID: 442475 [Multi-domain]  Cd Length: 545  Bit Score: 148.56  E-value: 8.02e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772242060   2 DVVYKENKLELLHYDAEAagieapdEEKEDVPILIVYALINRPYILDLQEERSVVRRLLEAGHDVYLIDWNEPSRLDQHL 81
Cdd:COG3243  181 KVVYRNDLMELIQYAPTT-------EKVHKTPLLIVPPWINKYYILDLQPGNSLVRYLVDQGFTVFLISWGNPDAEDRDL 253

                         90
                 ....*....|....*....
gi 772242060  82 TLDDYVNRYMDNCVDVVRD 100
Cdd:COG3243  254 GLDDYVEDGILAAVDAVRE 272
 
Name Accession Description Interval E-value
PhaC COG3243
Poly-beta-hydroxybutyrate synthase [Lipid transport and metabolism];
2-100 8.02e-44

Poly-beta-hydroxybutyrate synthase [Lipid transport and metabolism];


Pssm-ID: 442475 [Multi-domain]  Cd Length: 545  Bit Score: 148.56  E-value: 8.02e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772242060   2 DVVYKENKLELLHYDAEAagieapdEEKEDVPILIVYALINRPYILDLQEERSVVRRLLEAGHDVYLIDWNEPSRLDQHL 81
Cdd:COG3243  181 KVVYRNDLMELIQYAPTT-------EKVHKTPLLIVPPWINKYYILDLQPGNSLVRYLVDQGFTVFLISWGNPDAEDRDL 253

                         90
                 ....*....|....*....
gi 772242060  82 TLDDYVNRYMDNCVDVVRD 100
Cdd:COG3243  254 GLDDYVEDGILAAVDAVRE 272
PHA_synth_III_C TIGR01836
poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; This model represents the PhaC ...
 2-99 2.52e-36

poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; This model represents the PhaC subunit of a heterodimeric form of polyhydroxyalkanoic acid (PHA) synthase. Excepting the PhaC of Bacillus megaterium (which needs PhaR), all members require PhaE (TIGR01834) for activity and are designated class III. This enzyme builds ester polymers for carbon and energy storage that accumulate in inclusions, and both this enzyme and the depolymerase associate with the inclusions. Class III enzymes polymerize short-chain-length hydroxyalkanoates. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 130895  Cd Length: 350  Bit Score: 125.62  E-value: 2.52e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772242060    2 DVVYKENKLELLHYDAEAAGIEApdeekedVPILIVYALINRPYILDLQEERSVVRRLLEAGHDVYLIDWNEPSRLDQHL 81
Cdd:TIGR01836  40 EVVYREDKVVLYRYTPVKDNTHK-------TPLLIVYALVNRPYMLDLQEDRSLVRGLLERGQDVYLIDWGYPDRADRYL 112

                          90
                  ....*....|....*...
gi 772242060   82 TLDDYVNRYMDNCVDVVR 99
Cdd:TIGR01836 113 TLDDYINGYIDKCVDYIC 130
PhaC_N pfam07167
Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; This family represents the N-terminal ...
 3-57 2.62e-06

Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; This family represents the N-terminal region of the bacterial poly-beta-hydroxybutyrate polymerase (PhaC). Polyhydroxyalkanoic acids (PHAs) are carbon and energy reserve polymers produced in some bacteria when carbon sources are plentiful and another nutrient, such as nitrogen, phosphate, oxygen, or sulfur, becomes limiting. PHAs composed of monomeric units ranging from 3 to 14 carbons exist in nature. When the carbon source is exhausted, PHA is utilized by the bacterium. PhaC links D-(-)-3-hydroxybutyrl-CoA to an existing PHA molecule by the formation of an ester bond. This family appears to be a partial segment of an alpha/beta hydrolase domain.


Pssm-ID: 462110 [Multi-domain]  Cd Length: 173  Bit Score: 43.40  E-value: 2.62e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 772242060    3 VVYKENKLELLHYdaeaagieAPDEEK-EDVPILIVYALINRPYILDLQEERSVVR 57
Cdd:pfam07167 124 VVFRNELMELIQY--------KPTTEKvHKRPLLIVPPWINKFYILDLSPQNSLVR 171
 
Name Accession Description Interval E-value
PhaC COG3243
Poly-beta-hydroxybutyrate synthase [Lipid transport and metabolism];
2-100 8.02e-44

Poly-beta-hydroxybutyrate synthase [Lipid transport and metabolism];


Pssm-ID: 442475 [Multi-domain]  Cd Length: 545  Bit Score: 148.56  E-value: 8.02e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772242060   2 DVVYKENKLELLHYDAEAagieapdEEKEDVPILIVYALINRPYILDLQEERSVVRRLLEAGHDVYLIDWNEPSRLDQHL 81
Cdd:COG3243  181 KVVYRNDLMELIQYAPTT-------EKVHKTPLLIVPPWINKYYILDLQPGNSLVRYLVDQGFTVFLISWGNPDAEDRDL 253

                         90
                 ....*....|....*....
gi 772242060  82 TLDDYVNRYMDNCVDVVRD 100
Cdd:COG3243  254 GLDDYVEDGILAAVDAVRE 272
PHA_synth_III_C TIGR01836
poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; This model represents the PhaC ...
 2-99 2.52e-36

poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; This model represents the PhaC subunit of a heterodimeric form of polyhydroxyalkanoic acid (PHA) synthase. Excepting the PhaC of Bacillus megaterium (which needs PhaR), all members require PhaE (TIGR01834) for activity and are designated class III. This enzyme builds ester polymers for carbon and energy storage that accumulate in inclusions, and both this enzyme and the depolymerase associate with the inclusions. Class III enzymes polymerize short-chain-length hydroxyalkanoates. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 130895  Cd Length: 350  Bit Score: 125.62  E-value: 2.52e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 772242060    2 DVVYKENKLELLHYDAEAAGIEApdeekedVPILIVYALINRPYILDLQEERSVVRRLLEAGHDVYLIDWNEPSRLDQHL 81
Cdd:TIGR01836  40 EVVYREDKVVLYRYTPVKDNTHK-------TPLLIVYALVNRPYMLDLQEDRSLVRGLLERGQDVYLIDWGYPDRADRYL 112

                          90
                  ....*....|....*...
gi 772242060   82 TLDDYVNRYMDNCVDVVR 99
Cdd:TIGR01836 113 TLDDYINGYIDKCVDYIC 130
PhaC_N pfam07167
Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; This family represents the N-terminal ...
 3-57 2.62e-06

Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; This family represents the N-terminal region of the bacterial poly-beta-hydroxybutyrate polymerase (PhaC). Polyhydroxyalkanoic acids (PHAs) are carbon and energy reserve polymers produced in some bacteria when carbon sources are plentiful and another nutrient, such as nitrogen, phosphate, oxygen, or sulfur, becomes limiting. PHAs composed of monomeric units ranging from 3 to 14 carbons exist in nature. When the carbon source is exhausted, PHA is utilized by the bacterium. PhaC links D-(-)-3-hydroxybutyrl-CoA to an existing PHA molecule by the formation of an ester bond. This family appears to be a partial segment of an alpha/beta hydrolase domain.


Pssm-ID: 462110 [Multi-domain]  Cd Length: 173  Bit Score: 43.40  E-value: 2.62e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 772242060    3 VVYKENKLELLHYdaeaagieAPDEEK-EDVPILIVYALINRPYILDLQEERSVVR 57
Cdd:pfam07167 124 VVFRNELMELIQY--------KPTTEKvHKRPLLIVPPWINKFYILDLSPQNSLVR 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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