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Conserved domains on  [gi|771609343|ref|WP_045220295|]
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MULTISPECIES: phosphopantetheine-binding protein [Ralstonia]

Protein Classification

acyl carrier protein( domain architecture ID 516)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

Gene Ontology:  GO:0006633
PubMed:  30543875

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PP-binding super family cl09936
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 1-84 8.11e-20

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


The actual alignment was detected with superfamily member PRK09184:

Pssm-ID: 447865  Cd Length: 89  Bit Score: 75.86  E-value: 8.11e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 771609343  1 MDSLKLEIKQLLIEALDLEDMTPADIDDDAPLFDTnGIGLDSIDALEIGIVLRKRYQLTIAANDEHTREHFRSVNTLAAL 80
Cdd:PRK09184  4 MTALERELAELIVEELNLEDVQPESIDADAPLYGE-GLGLDSIDILEIALVISKRYGFQLRSDNPDNQRIFASLRALAAY 82


                ....
gi 771609343 81 VKSQ 84
Cdd:PRK09184 83 VAAH 86
 
Name Accession Description Interval E-value
PRK09184 PRK09184
acyl carrier protein; Provisional
 1-84 8.11e-20

acyl carrier protein; Provisional


Pssm-ID: 181682  Cd Length: 89  Bit Score: 75.86  E-value: 8.11e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 771609343  1 MDSLKLEIKQLLIEALDLEDMTPADIDDDAPLFDTnGIGLDSIDALEIGIVLRKRYQLTIAANDEHTREHFRSVNTLAAL 80
Cdd:PRK09184  4 MTALERELAELIVEELNLEDVQPESIDADAPLYGE-GLGLDSIDILEIALVISKRYGFQLRSDNPDNQRIFASLRALAAY 82


                ....
gi 771609343 81 VKSQ 84
Cdd:PRK09184 83 VAAH 86
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-85 3.23e-08

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 46.00  E-value: 3.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 771609343  1 MDSLKLEIKQLLIEALDLEdmtPADIDDDAPLFDtnGIGLDSIDALEIGIVLRKRYQLTIAANDEhtrEHFRSVNTLAAL 80
Cdd:COG0236   3 REELEERLAEIIAEVLGVD---PEEITPDDSFFE--DLGLDSLDAVELIAALEEEFGIELPDTEL---FEYPTVADLADY 74


                ....*
gi 771609343 81 VKSQQ 85
Cdd:COG0236  75 LEEKL 79
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 7-64 1.02e-04

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 36.39  E-value: 1.02e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 771609343   7 EIKQLLIEALDLEdmtPADIDDDAPLFDtngIGLDSIDALEIGIVLRKRYQLTIAAND 64
Cdd:pfam00550  2 RLRELLAEVLGVP---AEEIDPDTDLFD---LGLDSLLAVELIARLEEEFGVEIPPSD 53
 
Name Accession Description Interval E-value
PRK09184 PRK09184
acyl carrier protein; Provisional
 1-84 8.11e-20

acyl carrier protein; Provisional


Pssm-ID: 181682  Cd Length: 89  Bit Score: 75.86  E-value: 8.11e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 771609343  1 MDSLKLEIKQLLIEALDLEDMTPADIDDDAPLFDTnGIGLDSIDALEIGIVLRKRYQLTIAANDEHTREHFRSVNTLAAL 80
Cdd:PRK09184  4 MTALERELAELIVEELNLEDVQPESIDADAPLYGE-GLGLDSIDILEIALVISKRYGFQLRSDNPDNQRIFASLRALAAY 82


                ....
gi 771609343 81 VKSQ 84
Cdd:PRK09184 83 VAAH 86
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-85 3.23e-08

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 46.00  E-value: 3.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 771609343  1 MDSLKLEIKQLLIEALDLEdmtPADIDDDAPLFDtnGIGLDSIDALEIGIVLRKRYQLTIAANDEhtrEHFRSVNTLAAL 80
Cdd:COG0236   3 REELEERLAEIIAEVLGVD---PEEITPDDSFFE--DLGLDSLDAVELIAALEEEFGIELPDTEL---FEYPTVADLADY 74


                ....*
gi 771609343 81 VKSQQ 85
Cdd:COG0236  75 LEEKL 79
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 7-64 1.02e-04

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 36.39  E-value: 1.02e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 771609343   7 EIKQLLIEALDLEdmtPADIDDDAPLFDtngIGLDSIDALEIGIVLRKRYQLTIAAND 64
Cdd:pfam00550  2 RLRELLAEVLGVP---AEEIDPDTDLFD---LGLDSLLAVELIARLEEEFGVEIPPSD 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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