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Conserved domains on  [gi|7710121|ref|NP_001418|]
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homeobox protein engrailed-2 [Homo sapiens]

Protein Classification

homeodomain and Engrail_1_C_sig domain-containing protein( domain architecture ID 11079054)

homeodomain and Engrail_1_C_sig domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
245-301 1.21e-25

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 97.19  E-value: 1.21e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 7710121    245 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKK 301
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Engrail_1_C_sig pfam10525
Engrailed homeobox C-terminal signature domain; Engrailed homeobox proteins are characterized ...
 302-332 2.07e-14

Engrailed homeobox C-terminal signature domain; Engrailed homeobox proteins are characterized by the presence of a conserved region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain. This domain of approximately 20 residues forms a kind of a signature pattern for this subfamily of proteins.


:

Pssm-ID: 431338  Cd Length: 31  Bit Score: 66.25  E-value: 2.07e-14
                          10        20        30
                  ....*....|....*....|....*....|.
gi 7710121    302 ATGNKNTLAVHLMAQGLYNHSTTAKEGKSDS 332
Cdd:pfam10525   1 ASGQKNPLALHLMAQGLYNHSTVTKQDEEDD 31
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
245-301 1.21e-25

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 97.19  E-value: 1.21e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 7710121    245 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKK 301
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 245-300 2.95e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.77  E-value: 2.95e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 7710121     245 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIK 300
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 245-301 1.64e-22

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 88.84  E-value: 1.64e-22
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 7710121  245 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKK 301
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
Engrail_1_C_sig pfam10525
Engrailed homeobox C-terminal signature domain; Engrailed homeobox proteins are characterized ...
 302-332 2.07e-14

Engrailed homeobox C-terminal signature domain; Engrailed homeobox proteins are characterized by the presence of a conserved region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain. This domain of approximately 20 residues forms a kind of a signature pattern for this subfamily of proteins.


Pssm-ID: 431338  Cd Length: 31  Bit Score: 66.25  E-value: 2.07e-14
                          10        20        30
                  ....*....|....*....|....*....|.
gi 7710121    302 ATGNKNTLAVHLMAQGLYNHSTTAKEGKSDS 332
Cdd:pfam10525   1 ASGQKNPLALHLMAQGLYNHSTVTKQDEEDD 31
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
243-308 1.09e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.07  E-value: 1.09e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7710121  243 EDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNT 308
Cdd:COG5576  50 PPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVE 115
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
245-301 1.21e-25

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 97.19  E-value: 1.21e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 7710121    245 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKK 301
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 245-300 2.95e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.77  E-value: 2.95e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 7710121     245 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIK 300
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 245-301 1.64e-22

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 88.84  E-value: 1.64e-22
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 7710121  245 KRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKK 301
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
Engrail_1_C_sig pfam10525
Engrailed homeobox C-terminal signature domain; Engrailed homeobox proteins are characterized ...
 302-332 2.07e-14

Engrailed homeobox C-terminal signature domain; Engrailed homeobox proteins are characterized by the presence of a conserved region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain. This domain of approximately 20 residues forms a kind of a signature pattern for this subfamily of proteins.


Pssm-ID: 431338  Cd Length: 31  Bit Score: 66.25  E-value: 2.07e-14
                          10        20        30
                  ....*....|....*....|....*....|.
gi 7710121    302 ATGNKNTLAVHLMAQGLYNHSTTAKEGKSDS 332
Cdd:pfam10525   1 ASGQKNPLALHLMAQGLYNHSTVTKQDEEDD 31
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
243-308 1.09e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.07  E-value: 1.09e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7710121  243 EDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNT 308
Cdd:COG5576  50 PPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVE 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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