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Conserved domains on  [gi|7706663|ref|NP_057228|]
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COMM domain-containing protein 10 isoform a [Homo sapiens]

Protein Classification

COMM domain-containing protein 10( domain architecture ID 10140838)

COMM domain-containing protein 10 (COMMD10) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and may also down-regulate activation of NF-kappa-B

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd10 cd04758
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of ...
 15-201 2.75e-84

COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240106 [Multi-domain]  Cd Length: 186  Bit Score: 247.29  E-value: 2.75e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706663   15 MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQ 94
Cdd:cd04758   1 IKEAVSLINSIDTEKFPRLLSRLFQKLHLKAERSFSEEEEEKLQEAFKLLSQDLKLLLETISFILEQAAYHNLKPSNLQQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706663   95 QLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSkSLEK 174
Cdd:cd04758  81 QLRNILLLEDKASAFVNAWEAEGEDVLEKLRSRILAPNQLEDVSWRLNLQMSSSTQAKLKSPLAVLELGVTSEDG-NLEK 159

                       170       180
                ....*....|....*....|....*..
gi 7706663  175 VLVEFSHKELFDFYNKLETIQAQLDSL 201
Cdd:cd04758 160 INLEFNHEELLEFYNQLESIQEQLDSL 186
 
Name Accession Description Interval E-value
Commd10 cd04758
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of ...
 15-201 2.75e-84

COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240106 [Multi-domain]  Cd Length: 186  Bit Score: 247.29  E-value: 2.75e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706663   15 MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQ 94
Cdd:cd04758   1 IKEAVSLINSIDTEKFPRLLSRLFQKLHLKAERSFSEEEEEKLQEAFKLLSQDLKLLLETISFILEQAAYHNLKPSNLQQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706663   95 QLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSkSLEK 174
Cdd:cd04758  81 QLRNILLLEDKASAFVNAWEAEGEDVLEKLRSRILAPNQLEDVSWRLNLQMSSSTQAKLKSPLAVLELGVTSEDG-NLEK 159

                       170       180
                ....*....|....*....|....*..
gi 7706663  175 VLVEFSHKELFDFYNKLETIQAQLDSL 201
Cdd:cd04758 160 INLEFNHEELLEFYNQLESIQEQLDSL 186
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 133-194 1.53e-11

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 57.56  E-value: 1.53e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7706663    133 KLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKSlEKVLVEFSHKELFDFYNKLETI 194
Cdd:pfam07258   4 QLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGSS-EEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd10 cd04758
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of ...
 15-201 2.75e-84

COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240106 [Multi-domain]  Cd Length: 186  Bit Score: 247.29  E-value: 2.75e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706663   15 MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQ 94
Cdd:cd04758   1 IKEAVSLINSIDTEKFPRLLSRLFQKLHLKAERSFSEEEEEKLQEAFKLLSQDLKLLLETISFILEQAAYHNLKPSNLQQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706663   95 QLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSkSLEK 174
Cdd:cd04758  81 QLRNILLLEDKASAFVNAWEAEGEDVLEKLRSRILAPNQLEDVSWRLNLQMSSSTQAKLKSPLAVLELGVTSEDG-NLEK 159

                       170       180
                ....*....|....*....|....*..
gi 7706663  175 VLVEFSHKELFDFYNKLETIQAQLDSL 201
Cdd:cd04758 160 INLEFNHEELLEFYNQLESIQEQLDSL 186
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 117-198 1.01e-13

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 63.87  E-value: 1.01e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706663  117 GQETVEKFRQRILA-PCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKSLEKVLVEFSHKELFDFYNKLETIQ 195
Cdd:cd04748   5 NKAEIEELLSKQSLsLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGDNNSSEKICFEMTKEELQNFLNKLKKIK 84


                ...
gi 7706663  196 AQL 198
Cdd:cd04748  85 AQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 133-194 1.53e-11

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 57.56  E-value: 1.53e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7706663    133 KLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKSlEKVLVEFSHKELFDFYNKLETI 194
Cdd:pfam07258   4 QLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGSS-EEVTFELSKEQLQDLLNELEEA 64
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 56-201 1.12e-06

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 46.65  E-value: 1.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706663   56 KLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKLE 135
Cdd:cd04752  29 KLTADAKFESGDVKASIAVLSFILSSAAKYNVDGESLSSELQQLGLPKEHATSLCRSYEEKQSKLQESLRANSLRLSRLE 108

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7706663  136 TVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKSLEKVLVEFSHKELFDFYNKLETIQAQLDSL 201
Cdd:cd04752 109 SVDWRVDYILSSSELQEVNEPLVQLRLKVRNADTGEITPHPFSVSADKFRVLLAELKQAQTLMETL 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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