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Conserved domains on  [gi|768893812|gb|AJW21886|]
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Dpm1p [Saccharomyces cerevisiae YJM470]

Protein Classification

polyprenol monophosphomannose synthase( domain architecture ID 10157756)

polyprenol monophosphomannose synthase transfers mannose from GDP-mannose to lipid acceptors, such as dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 7-234 4.99e-96

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


:

Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 280.96  E-value: 4.99e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   7 VIVPAYHEKLNIKPLTTRLFAGMSPEmakKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYEA 86
Cdd:cd06442    1 IIIPTYNERENIPELIERLDAALKGI---DYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIVRPGKRGLGSAYIEGFKAA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812  87 KGQYLVCMDADLQHPPETVSKLFESLH--DHAFTLGTRYAPGVGIdKDWPMYRRVISSTARMMARPL--TIASDPMSGFF 162
Cdd:cd06442   78 RGDVIVVMDADLSHPPEYIPELLEAQLegGADLVIGSRYVEGGGV-EGWGLKRKLISRGANLLARLLlgRKVSDPTSGFR 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768893812 163 GLQKKYLENCNPrDINSQGFKIALELLAKLplpRDPRVAIGEVPFTFGVRTEGESKLSGKVIIQYLQQLKEL 234
Cdd:cd06442  157 AYRREVLEKLID-SLVSKGYKFQLELLVRA---RRLGYRIVEVPITFVDREHGESKLGGKEIVEYLKGLLRL 224
 
Name Accession Description Interval E-value
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 7-234 4.99e-96

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 280.96  E-value: 4.99e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   7 VIVPAYHEKLNIKPLTTRLFAGMSPEmakKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYEA 86
Cdd:cd06442    1 IIIPTYNERENIPELIERLDAALKGI---DYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIVRPGKRGLGSAYIEGFKAA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812  87 KGQYLVCMDADLQHPPETVSKLFESLH--DHAFTLGTRYAPGVGIdKDWPMYRRVISSTARMMARPL--TIASDPMSGFF 162
Cdd:cd06442   78 RGDVIVVMDADLSHPPEYIPELLEAQLegGADLVIGSRYVEGGGV-EGWGLKRKLISRGANLLARLLlgRKVSDPTSGFR 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768893812 163 GLQKKYLENCNPrDINSQGFKIALELLAKLplpRDPRVAIGEVPFTFGVRTEGESKLSGKVIIQYLQQLKEL 234
Cdd:cd06442  157 AYRREVLEKLID-SLVSKGYKFQLELLVRA---RRLGYRIVEVPITFVDREHGESKLGGKEIVEYLKGLLRL 224
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 3-236 1.48e-35

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 127.12  E-value: 1.48e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   3 IEYSVIVPAYHEKLNIKPLTTRLFAGMspEMAKKTELIFVDDNSQDGSVEEVDAL--AHQGYNVRIIVRTNERGLSSAVL 80
Cdd:PLN02726   9 MKYSIIVPTYNERLNIALIVYLIFKAL--QDVKDFEIIVVDDGSPDGTQDVVKQLqkVYGEDRILLRPRPGKLGLGTAYI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812  81 KGFYEAKGQYLVCMDADLQHPPETVSKLFESLHDHAFTL--GTRYAPGVGIdKDWPMYRRVISSTARMMARPL--TIASD 156
Cdd:PLN02726  87 HGLKHASGDFVVIMDADLSHHPKYLPSFIKKQRETGADIvtGTRYVKGGGV-HGWDLRRKLTSRGANVLAQTLlwPGVSD 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812 157 pMSGFFGLQKK-YLENCNPRdINSQGFKIALELLAKlplPRDPRVAIGEVPFTFGVRTEGESKLSGKVIIQYLQQLKELY 235
Cdd:PLN02726 166 -LTGSFRLYKRsALEDLVSS-VVSKGYVFQMEIIVR---ASRKGYRIEEVPITFVDRVYGESKLGGSEIVQYLKGLLYLL 240


                 .
gi 768893812 236 V 236
Cdd:PLN02726 241 L 241
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 6-170 2.28e-34

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 121.73  E-value: 2.28e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812    6 SVIVPAYHEKLNIKPLTTRLFAgmspEMAKKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYE 85
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLN----QTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   86 AKGQYLVCMDADLQHPPETVSKLFESL--HDHAFTLGTRYAPGVGIDKDWPMYRRVIS--STARMMARPLTIASDPMSGF 161
Cdd:pfam00535  77 ATGDYIAFLDADDEVPPDWLEKLVEALeeDGADVVVGSRYVIFGETGEYRRASRITLSrlPFFLGLRLLGLNLPFLIGGF 156


                  ....*....
gi 768893812  162 FGLQKKYLE 170
Cdd:pfam00535 157 ALYRREALE 165
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 6-228 9.66e-32

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 116.34  E-value: 9.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   6 SVIVPAYHEKLNIKPLTTRLFAGMSPEMakktELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYE 85
Cdd:COG0463    5 SVVIPTYNEEEYLEEALESLLAQTYPDF----EIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812  86 AKGQYLVCMDADLQHPPETVSKLFESL--HDHAFTLGTRYapgvgIDKDWPMYRRVISSTARMMARpLTIASDPMSGFFG 163
Cdd:COG0463   81 ARGDYIAFLDADDQLDPEKLEELVAALeeGPADLVYGSRL-----IREGESDLRRLGSRLFNLVRL-LTNLPDSTSGFRL 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768893812 164 LQKKYLENCNPRDinsqGFKIALELLAKLPLprdpRVAIGEVPFTFgvrTEGESKLSGKVIIQYL 228
Cdd:COG0463  155 FRREVLEELGFDE----GFLEDTELLRALRH----GFRIAEVPVRY---RAGESKLNLRDLLRLL 208
 
Name Accession Description Interval E-value
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 7-234 4.99e-96

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 280.96  E-value: 4.99e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   7 VIVPAYHEKLNIKPLTTRLFAGMSPEmakKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYEA 86
Cdd:cd06442    1 IIIPTYNERENIPELIERLDAALKGI---DYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIVRPGKRGLGSAYIEGFKAA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812  87 KGQYLVCMDADLQHPPETVSKLFESLH--DHAFTLGTRYAPGVGIdKDWPMYRRVISSTARMMARPL--TIASDPMSGFF 162
Cdd:cd06442   78 RGDVIVVMDADLSHPPEYIPELLEAQLegGADLVIGSRYVEGGGV-EGWGLKRKLISRGANLLARLLlgRKVSDPTSGFR 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768893812 163 GLQKKYLENCNPrDINSQGFKIALELLAKLplpRDPRVAIGEVPFTFGVRTEGESKLSGKVIIQYLQQLKEL 234
Cdd:cd06442  157 AYRREVLEKLID-SLVSKGYKFQLELLVRA---RRLGYRIVEVPITFVDREHGESKLGGKEIVEYLKGLLRL 224
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 7-192 1.36e-47

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 156.58  E-value: 1.36e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   7 VIVPAYHEKLNIKPLTTRLFAGMSPEmaKKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYEA 86
Cdd:cd04179    1 VVIPAYNEEENIPELVERLLAVLEEG--YDYEIIVVDDGSTDGTAEIARELAARVPRVRVIRLSRNFGKGAAVRAGFKAA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812  87 KGQYLVCMDADLQHPPETVSKLFESL--HDHAFTLGTRYAPgvGIDKDWPMYRRVISSTARMMARPLTIA--SDPMSGFF 162
Cdd:cd04179   79 RGDIVVTMDADLQHPPEDIPKLLEKLleGGADVVIGSRFVR--GGGAGMPLLRRLGSRLFNFLIRLLLGVriSDTQSGFR 156

                        170       180       190
                 ....*....|....*....|....*....|
gi 768893812 163 GLQKKYLENCNPRdINSQGFKIALELLAKL 192
Cdd:cd04179  157 LFRREVLEALLSL-LESNGFEFGLELLVGA 185
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 3-236 1.48e-35

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 127.12  E-value: 1.48e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   3 IEYSVIVPAYHEKLNIKPLTTRLFAGMspEMAKKTELIFVDDNSQDGSVEEVDAL--AHQGYNVRIIVRTNERGLSSAVL 80
Cdd:PLN02726   9 MKYSIIVPTYNERLNIALIVYLIFKAL--QDVKDFEIIVVDDGSPDGTQDVVKQLqkVYGEDRILLRPRPGKLGLGTAYI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812  81 KGFYEAKGQYLVCMDADLQHPPETVSKLFESLHDHAFTL--GTRYAPGVGIdKDWPMYRRVISSTARMMARPL--TIASD 156
Cdd:PLN02726  87 HGLKHASGDFVVIMDADLSHHPKYLPSFIKKQRETGADIvtGTRYVKGGGV-HGWDLRRKLTSRGANVLAQTLlwPGVSD 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812 157 pMSGFFGLQKK-YLENCNPRdINSQGFKIALELLAKlplPRDPRVAIGEVPFTFGVRTEGESKLSGKVIIQYLQQLKELY 235
Cdd:PLN02726 166 -LTGSFRLYKRsALEDLVSS-VVSKGYVFQMEIIVR---ASRKGYRIEEVPITFVDRVYGESKLGGSEIVQYLKGLLYLL 240


                 .
gi 768893812 236 V 236
Cdd:PLN02726 241 L 241
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 6-170 2.28e-34

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 121.73  E-value: 2.28e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812    6 SVIVPAYHEKLNIKPLTTRLFAgmspEMAKKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYE 85
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLN----QTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   86 AKGQYLVCMDADLQHPPETVSKLFESL--HDHAFTLGTRYAPGVGIDKDWPMYRRVIS--STARMMARPLTIASDPMSGF 161
Cdd:pfam00535  77 ATGDYIAFLDADDEVPPDWLEKLVEALeeDGADVVVGSRYVIFGETGEYRRASRITLSrlPFFLGLRLLGLNLPFLIGGF 156


                  ....*....
gi 768893812  162 FGLQKKYLE 170
Cdd:pfam00535 157 ALYRREALE 165
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 6-228 9.66e-32

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 116.34  E-value: 9.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   6 SVIVPAYHEKLNIKPLTTRLFAGMSPEMakktELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYE 85
Cdd:COG0463    5 SVVIPTYNEEEYLEEALESLLAQTYPDF----EIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812  86 AKGQYLVCMDADLQHPPETVSKLFESL--HDHAFTLGTRYapgvgIDKDWPMYRRVISSTARMMARpLTIASDPMSGFFG 163
Cdd:COG0463   81 ARGDYIAFLDADDQLDPEKLEELVAALeeGPADLVYGSRL-----IREGESDLRRLGSRLFNLVRL-LTNLPDSTSGFRL 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768893812 164 LQKKYLENCNPRDinsqGFKIALELLAKLPLprdpRVAIGEVPFTFgvrTEGESKLSGKVIIQYL 228
Cdd:COG0463  155 FRREVLEELGFDE----GFLEDTELLRALRH----GFRIAEVPVRY---RAGESKLNLRDLLRLL 208
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 7-110 2.24e-22

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 91.00  E-value: 2.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   7 VIVPAYHEKLNIKPLTTRL---FAGMSPEMakktELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGF 83
Cdd:cd04187    1 IVVPVYNEEENLPELYERLkavLESLGYDY----EIIFVDDGSTDRTLEILRELAARDPRVKVIRLSRNFGQQAALLAGL 76

                         90       100
                 ....*....|....*....|....*..
gi 768893812  84 YEAKGQYLVCMDADLQHPPETVSKLFE 110
Cdd:cd04187   77 DHARGDAVITMDADLQDPPELIPEMLA 103
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 5-114 3.29e-18

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 82.10  E-value: 3.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   5 YSVIVPAYHEKLNIKPLTTRLFAGMSPemAKKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFY 84
Cdd:COG1215   31 VSVIIPAYNEEAVIEETLRSLLAQDYP--KEKLEVIVVDDGSTDETAEIARELAAEYPRVRVIERPENGGKAAALNAGLK 108

                         90       100       110
                 ....*....|....*....|....*....|
gi 768893812  85 EAKGQYLVCMDADLQHPPETVSKLFESLHD 114
Cdd:COG1215  109 AARGDIVVFLDADTVLDPDWLRRLVAAFAD 138
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 7-141 4.51e-17

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 77.22  E-value: 4.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   7 VIVPAYHEKLNIKPLTTRLFAGMSPEMAKKTELIFVDDNSQDGSVEEVDALAHQ-GYNVRIIVRTNERGLSSAVLKGFYE 85
Cdd:cd04188    1 VVIPAYNEEKRLPPTLEEAVEYLEERPSFSYEIIVVDDGSKDGTAEVARKLARKnPALIRVLTLPKNRGKGGAVRAGMLA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 768893812  86 AKGQYLVCMDADLQHPPETVSKLFESLH--DHAFTLGTRYAPGVGIDKDWPMYRRVIS 141
Cdd:cd04188   81 ARGDYILFADADLATPFEELEKLEEALKtsGYDIAIGSRAHLASAAVVKRSWLRNLLG 138
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 7-115 1.20e-15

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 72.15  E-value: 1.20e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   7 VIVPAYHEKLNIKplttRLFAGMSPEMAKKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLKGFYEA 86
Cdd:cd00761    1 VIIPAYNEEPYLE----RCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRVINEENQGLAAARNAGLKAA 76

                         90       100
                 ....*....|....*....|....*....
gi 768893812  87 KGQYLVCMDADLQHPPETVSKLFESLHDH 115
Cdd:cd00761   77 RGEYILFLDADDLLLPDWLERLVAELLAD 105
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 7-115 1.18e-12

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 64.56  E-value: 1.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   7 VIVPAYHEKLNIKPLTTRLFAGMSPEMakktELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNERGLSSAVLK-GFYE 85
Cdd:cd06423    1 IIVPAYNEEAVIERTIESLLALDYPKL----EVIVVDDGSTDDTLEILEELAALYIRRVLVVRDKENGGKAGALNaGLRH 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 768893812  86 AKGQYLVCMDADLQHPPETVSKLFESLHDH 115
Cdd:cd06423   77 AKGDIVVVLDADTILEPDALKRLVVPFFAD 106
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-110 1.76e-12

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 64.63  E-value: 1.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   1 MSIEYSVIVPAYHEKlnikPLTTRLFAGMSPEMAKKTELIFVDDNSQDGSVEEVDALAHQgyNVRIIVRTNERGLSSAVL 80
Cdd:COG1216    1 MRPKVSVVIPTYNRP----ELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELLAALAFP--RVRVIRNPENLGFAAARN 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 768893812  81 KGFYEAKGQYLVCMDADLQHPPETVSKLFE 110
Cdd:COG1216   75 LGLRAAGGDYLLFLDDDTVVEPDWLERLLA 104
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 6-124 6.03e-12

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 64.76  E-value: 6.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   6 SVIVPAYHEKLNIKPLTTRLFAGMSpEMAKKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNER-GLSSAVLKGFY 84
Cdd:PRK10714   9 SVVIPVYNEQESLPELIRRTTAACE-SLGKEYEILLIDDGSSDNSAEMLVEAAQAPDSHIVAILLNRNyGQHSAIMAGFS 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768893812  85 EAKGQYLVCMDADLQHPPETVSKLFESLHDHAFTLGTRYA 124
Cdd:PRK10714  88 HVTGDLIITLDADLQNPPEEIPRLVAKADEGYDVVGTVRQ 127
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 7-103 8.56e-10

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 57.30  E-value: 8.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   7 VIVPAYHEKLNIKPLTTRLFAGMSPemAKKTELIFVDDNSQDGSVEEVD-ALAHQGYNVRIIvRTNERGLS---SAVLKG 82
Cdd:cd04192    1 VVIAARNEAENLPRLLQSLSALDYP--KEKFEVILVDDHSTDGTVQILEfAAAKPNFQLKIL-NNSRVSISgkkNALTTA 77

                         90       100
                 ....*....|....*....|.
gi 768893812  83 FYEAKGQYLVCMDADLQHPPE 103
Cdd:cd04192   78 IKAAKGDWIVTTDADCVVPSN 98
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 6-112 9.54e-09

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 54.55  E-value: 9.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   6 SVIVPAYHEKLNIKPLTTRLFAGMSPEmaKKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVrtNERGLSSAVL-KGFY 84
Cdd:cd02525    3 SIIIPVRNEEKYIEELLESLLNQSYPK--DLIEIIVVDGGSTDGTREIVQEYAAKDPRIRLID--NPKRIQSAGLnIGIR 78

                         90       100
                 ....*....|....*....|....*...
gi 768893812  85 EAKGQYLVCMDADLQHPPETVSKLFESL 112
Cdd:cd02525   79 NSRGDIIIRVDAHAVYPKDYILELVEAL 106
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 5-140 1.37e-07

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 51.03  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   5 YSVIVPAYHEKLNIKPLTTRLFAGMSPEmakkTELIFVDDNSQDGSVEEVDALAHQgynvriiVRTNERGLSSAVLKGFY 84
Cdd:cd02522    1 LSIIIPTLNEAENLPRLLASLRRLNPLP----LEIIVVDGGSTDGTVAIARSAGVV-------VISSPKGRARQMNAGAA 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768893812  85 EAKGQYLVCMDADLQHPPETVSKLFESLHDHAFTLGT-RYApgvgIDKDWPMYRRVI 140
Cdd:cd02522   70 AARGDWLLFLHADTRLPPDWDAAIIETLRADGAVAGAfRLR----FDDPGPRLRLLE 122
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 6-110 2.59e-07

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 50.81  E-value: 2.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   6 SVIVPAYheklNIKPLTTRLFAGMSPEMAKKTELIFVDDNSQDGSVEEVDALAHQGYNVRIIVRTNErGLSSAVLKGFYE 85
Cdd:PRK10073   9 SIIIPLY----NAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLHQANA-GVSVARNTGLAV 83

                         90       100
                 ....*....|....*....|....*
gi 768893812  86 AKGQYLVCMDADLQHPPETVSKLFE 110
Cdd:PRK10073  84 ATGKYVAFPDADDVVYPTMYETLMT 108
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 2-122 4.15e-06

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 47.07  E-value: 4.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   2 SIEYSVIVPAYHEKLNIKPL---TTRLFAGMSPEMAK-KTELIFVDDNSQDGSVEEVDALAHQ----GYNVRIIVRTNER 73
Cdd:PTZ00260  69 DVDLSIVIPAYNEEDRLPKMlkeTIKYLESRSRKDPKfKYEIIIVNDGSKDKTLKVAKDFWRQninpNIDIRLLSLLRNK 148

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768893812  74 GLSSAVLKGFYEAKGQYLVCMDADLQHPPETVSKLFESLH-----DHAFTLGTR 122
Cdd:PTZ00260 149 GKGGAVRIGMLASRGKYILMVDADGATDIDDFDKLEDIMLkieqnGLGIVFGSR 202
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 6-108 5.19e-06

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 46.42  E-value: 5.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   6 SVIVPAYHEKLNIKpltTRL--FAGMSPEmAKKTELIFVDDNSQDGSVEEVDALAHQgyNVRIIVRTNERGLSSAVLKGF 83
Cdd:cd06439   32 TIIIPAYNEEAVIE---AKLenLLALDYP-RDRLEIIVVSDGSTDGTAEIAREYADK--GVKLLRFPERRGKAAALNRAL 105

                         90       100
                 ....*....|....*....|....*
gi 768893812  84 YEAKGQYLVCMDADLQHPPETVSKL 108
Cdd:cd06439  106 ALATGEIVVFTDANALLDPDALRLL 130
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 6-96 1.65e-05

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 45.27  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   6 SVIVPAYHEKLNIKPLT-TRLFAGMSPEMAKktELIFVDDNSQDGSVEEVDALAHQGYN--VRIIvRTNER-GLSSAVLK 81
Cdd:cd02510    1 SVIIIFHNEALSTLLRTvHSVINRTPPELLK--EIILVDDFSDKPELKLLLEEYYKKYLpkVKVL-RLKKReGLIRARIA 77

                         90
                 ....*....|....*
gi 768893812  82 GFYEAKGQYLVCMDA 96
Cdd:cd02510   78 GARAATGDVLVFLDS 92
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 5-172 1.83e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 44.67  E-value: 1.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812    5 YSVIVPAYHEKLNIKPLTTRLFAGMSPemakKTELIFVDDNSQDGSVEEVDALA--HQGYNVRIIVRTNERGLSSAVLK- 81
Cdd:pfam13641   4 VSVVVPAFNEDSVLGRVLEAILAQPYP----PVEVVVVVNPSDAETLDVAEEIAarFPDVRLRVIRNARLLGPTGKSRGl 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   82 --GFYEAKGQYLVCMDADLQHPPETVSK---LFESLHDHAFT------LGTRYAPGVGIDKdwpMYRRvissTARMMARP 150
Cdd:pfam13641  80 nhGFRAVKSDLVVLHDDDSVLHPGTLKKyvqYFDSPKVGAVGtpvfslNRSTMLSALGALE---FALR----HLRMMSLR 152

                         170       180
                  ....*....|....*....|...
gi 768893812  151 LTIASDPMSG-FFGLQKKYLENC 172
Cdd:pfam13641 153 LALGVLPLSGaGSAIRREVLKEL 175
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 7-129 6.83e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 42.16  E-value: 6.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768893812   7 VIVPAYheklNIKPLTTRLFAGMSPEMAKKTELIFVDDNSQDGSVEEvdaLAHQGYNVRIIVRTNERGLSSAVLKGFYEA 86
Cdd:cd04186    1 IIIVNY----NSLEYLKACLDSLLAQTYPDFEVIVVDNASTDGSVEL---LRELFPEVRLIRNGENLGFGAGNNQGIREA 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 768893812  87 KGQYLVCMDADLQHPPETVSKLFESLHDHaftlgtryaPGVGI 129
Cdd:cd04186   74 KGDYVLLLNPDTVVEPGALLELLDAAEQD---------PDVGI 107
CESA_CaSu_A2 cd06437
Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit ...
 39-107 2.74e-04

Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Cellulose synthase (CESA) catalyzes the polymerization reaction of cellulose using UDP-glucose as the substrate. Cellulose is an aggregate of unbranched polymers of beta-1,4-linked glucose residues, which is an abundant polysaccharide produced by plants and in varying degrees by several other organisms including algae, bacteria, fungi, and even some animals. Genomes from higher plants harbor multiple CESA genes. There are ten in Arabidopsis. At least three different CESA proteins are required to form a functional complex. In Arabidopsis, CESA1, 3 and 6 and CESA4, 7 and 8, are required for cellulose biosynthesis during primary and secondary cell wall formation. CESA2 is very closely related to CESA6 and is viewed as a prime substitute for CESA6. They functionally compensate each other. The cesa2 and cesa6 double mutant plants were significantly smaller, while the single mutant plants were almost normal.


Pssm-ID: 133059 [Multi-domain]  Cd Length: 232  Bit Score: 41.14  E-value: 2.74e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768893812  39 LIFVDDNSQDGSVEE----VDALAHQGYNVRIIVRTNERGLSSAVLK-GFYEAKGQYLVCMDADLQHPPETVSK 107
Cdd:cd06437   34 EIQVLDDSTDETVRLareiVEEYAAQGVNIKHVRRADRTGYKAGALAeGMKVAKGEYVAIFDADFVPPPDFLQK 107
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 38-97 3.81e-04

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 40.65  E-value: 3.81e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768893812  38 ELIFVDDNSQDGSVEEV-DALAHQGYNVRIIVRTNERGLSSAVLKGFYEAKGQYLVCMDAD 97
Cdd:cd04184   33 ELCIADDASTDPEVKRVlKKYAAQDPRIKVVFREENGGISAATNSALELATGEFVALLDHD 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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