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Conserved domains on  [gi|768883811|gb|AJW11908|]
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Sge1p [Saccharomyces cerevisiae YJM1190]

Protein Classification

MDR family MFS transporter( domain architecture ID 13024942)

MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell

CATH:  1.20.1250.20
Gene Ontology:  GO:0016020|GO:0055085|GO:0022857
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 24-531 1.18e-77

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 247.86  E-value: 1.18e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  24 DIVIVVTLYDTIGIKFHDFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGR 103
Cdd:cd17502   11 DQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGR 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 104 VVAGFGGSGIESLAFVVGTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILafcn 183
Cdd:cd17502   91 AIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL---- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 184 tsgephqkmwlpskikkimnydygellkasfwkntfevlvfkldmvgiilssagftllmlglsfggnnfpwnsgiiicff 263
Cdd:cd17502      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 264 tvgpillllfcaydfhflpllglhydnkrikplltwniasnCGIFTSSITGFLSCFAYELQSAYLVQLYQLVFKKKPTLA 343
Cdd:cd17502  167 -----------------------------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKS 205

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 344 SIHLWELSIPAMIATMAIAYLNSKYGIIKPAIVFGVLCGIVGSGLFTLINGELSQS--IGYSILPGIAFGSIFQATLLSS 421
Cdd:cd17502  206 GVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSVGAGLLTTLTLDTSKWllIGYLILLGLGLGIGFQQPLVAV 285

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 422 QAQITSDDpdfqnkFIEVTAFNSFAKSLGFAFGgnmgamiftaslknqmrssqlnipqftsvetllaystehydgpqssl 501
Cdd:cd17502  286 QNAVPPAD------VGVATATNTFFRSLGGTLG----------------------------------------------- 312

                        490       500       510
                 ....*....|....*....|....*....|
gi 768883811 502 skfinTAIHDVFYCALGCYALSFFFGIFTS 531
Cdd:cd17502  313 -----VAITDVFLVALALAALAFLLSLFLP 337
 
Name Accession Description Interval E-value
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 24-531 1.18e-77

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 247.86  E-value: 1.18e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  24 DIVIVVTLYDTIGIKFHDFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGR 103
Cdd:cd17502   11 DQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGR 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 104 VVAGFGGSGIESLAFVVGTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILafcn 183
Cdd:cd17502   91 AIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL---- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 184 tsgephqkmwlpskikkimnydygellkasfwkntfevlvfkldmvgiilssagftllmlglsfggnnfpwnsgiiicff 263
Cdd:cd17502      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 264 tvgpillllfcaydfhflpllglhydnkrikplltwniasnCGIFTSSITGFLSCFAYELQSAYLVQLYQLVFKKKPTLA 343
Cdd:cd17502  167 -----------------------------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKS 205

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 344 SIHLWELSIPAMIATMAIAYLNSKYGIIKPAIVFGVLCGIVGSGLFTLINGELSQS--IGYSILPGIAFGSIFQATLLSS 421
Cdd:cd17502  206 GVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSVGAGLLTTLTLDTSKWllIGYLILLGLGLGIGFQQPLVAV 285

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 422 QAQITSDDpdfqnkFIEVTAFNSFAKSLGFAFGgnmgamiftaslknqmrssqlnipqftsvetllaystehydgpqssl 501
Cdd:cd17502  286 QNAVPPAD------VGVATATNTFFRSLGGTLG----------------------------------------------- 312

                        490       500       510
                 ....*....|....*....|....*....|
gi 768883811 502 skfinTAIHDVFYCALGCYALSFFFGIFTS 531
Cdd:cd17502  313 -----VAITDVFLVALALAALAFLLSLFLP 337
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 41-390 6.67e-28

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 116.71  E-value: 6.67e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811   41 DFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVV 120
Cdd:TIGR00711  35 SLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFST 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  121 GTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAFcntsgephqkmwlpskikk 200
Cdd:TIGR00711 115 LLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFF------------------- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  201 imnydygellkasFWKNTFEVLVFKLDMVGIILSSAGFTLLMLGLSFGGNNFPWNSGIIICFFTVGPILLLLFCAYDfhf 280
Cdd:TIGR00711 176 -------------ILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWE--- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  281 lpllgLHYDNKRIKPLLTWNIASNCGIFTSSITGFLScfayeLQSAYLV-QLYQLVFKKKPTLASIHLWELSIPAMIATM 359
Cdd:TIGR00711 240 -----LTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGL-----YGSFYLLpLYLQQVLGYTALQAGLHILPVGLAPMLSSP 309

                         330       340       350
                  ....*....|....*....|....*....|.
gi 768883811  360 AIAYLNSKYGIIKPAIVfGVLCGIVGSGLFT 390
Cdd:TIGR00711 310 IAGRMGDKIDPRKLVTI-GLILYAVGFYWRA 339
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
24-276 1.45e-24

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 105.06  E-value: 1.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  24 DIVIVVTLYDTIGIKFH-DFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISG 102
Cdd:COG2814   25 GIGIVLPALPLIAADLGaSPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 103 RVVAGFGGSGIESLAFVVGTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAFC 182
Cdd:COG2814  105 RFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 183 NTSGEPHQKMWLPSKIKKImnydygeLLKASFWKNTFEVLVFKLDMVGIILSSAGFTLLMLGLSfggnnfPWNSGIIICF 262
Cdd:COG2814  185 LPESRPAARARLRGSLREL-------LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS------ASAAGLLLAL 251

                        250
                 ....*....|....
gi 768883811 263 FTVGPILLLLFCAY 276
Cdd:COG2814  252 FGLGGVLGALLAGR 265
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 44-528 1.23e-17

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 86.26  E-value: 1.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811   44 NIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGtS 123
Cdd:pfam06609  79 NQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAGASPLFIG-E 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  124 IVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAfcntsgephqkMWL-PSKIKKIm 202
Cdd:pfam06609 158 LMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLII-----------IWYhPPSFAQL- 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  203 nydYGEllKASFWKNtfevlVFKLDMVGIILSSAGFTLLMLGLSFGGN-NFPWNSGIIICFFTVGPILLLLFCAYDFHfl 281
Cdd:pfam06609 226 ---HGK--KARKRDE-----LAKLDWIGIFLVIAGTSLFLLGVSWGGKpNNPWNSAKIIGLISSGAGSLVIFALYEVF-- 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  282 pllglhydNKRIKPLLTWNIASN-----CGIFTSSITGFLSCFAYELQSAYLVQLYQlvfkkkptlASIHLWE----LSI 352
Cdd:pfam06609 294 --------GKPEQPIIPPALFKDtrgfvCILIISSIMGAMHLCLTIIYPQQVINIFG---------SSLKNWEetawMSA 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  353 PAMIATMA-IAYLNSKYGIIKP---AIVFGVLCGIVGSGLFTLINGELSQS-IGYSILPGIAFGSIFQATLLssQAQITS 427
Cdd:pfam06609 357 TASFGTGAgVMILGNLFHLIRHirwQILVGALWLTAFLGAMSSINRDNKNAaIALSFFSGFVVAWAQDITML--LVQFIT 434

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  428 DDPDFQNKFIEVTAFNSFAKSLGFA----FGGNMGAMIFTASLKNQMRSSqlNIPQFTSVETLLAYSTEHYD------GP 497
Cdd:pfam06609 435 TDEDLGVAFAVVAAARPFAGSIFTAafisLYSNQYPKEIASHLSSALRGT--DFPQASFPSLLEAAKSGRIDavkalpGM 512

                         490       500       510
                  ....*....|....*....|....*....|.
gi 768883811  498 QSSLSKFINTAIHDVFYCAlgcYALSFFFGI 528
Cdd:pfam06609 513 TNEIAAVVSQAMADSYTAS---YANVYYFAM 540
PRK10504 PRK10504
putative transporter; Provisional
 48-179 1.03e-10

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 63.98  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  48 LVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIV-R 126
Cdd:PRK10504  50 VIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVpR 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 768883811 127 ENHRGIMiTALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLP---IGAFAFIIL 179
Cdd:PRK10504 130 EQYMAAM-TFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPvgiIGAIATLML 184
 
Name Accession Description Interval E-value
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 24-531 1.18e-77

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 247.86  E-value: 1.18e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  24 DIVIVVTLYDTIGIKFHDFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGR 103
Cdd:cd17502   11 DQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGR 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 104 VVAGFGGSGIESLAFVVGTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILafcn 183
Cdd:cd17502   91 AIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL---- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 184 tsgephqkmwlpskikkimnydygellkasfwkntfevlvfkldmvgiilssagftllmlglsfggnnfpwnsgiiicff 263
Cdd:cd17502      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 264 tvgpillllfcaydfhflpllglhydnkrikplltwniasnCGIFTSSITGFLSCFAYELQSAYLVQLYQLVFKKKPTLA 343
Cdd:cd17502  167 -----------------------------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKS 205

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 344 SIHLWELSIPAMIATMAIAYLNSKYGIIKPAIVFGVLCGIVGSGLFTLINGELSQS--IGYSILPGIAFGSIFQATLLSS 421
Cdd:cd17502  206 GVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSVGAGLLTTLTLDTSKWllIGYLILLGLGLGIGFQQPLVAV 285

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 422 QAQITSDDpdfqnkFIEVTAFNSFAKSLGFAFGgnmgamiftaslknqmrssqlnipqftsvetllaystehydgpqssl 501
Cdd:cd17502  286 QNAVPPAD------VGVATATNTFFRSLGGTLG----------------------------------------------- 312

                        490       500       510
                 ....*....|....*....|....*....|
gi 768883811 502 skfinTAIHDVFYCALGCYALSFFFGIFTS 531
Cdd:cd17502  313 -----VAITDVFLVALALAALAFLLSLFLP 337
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 24-529 9.80e-45

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 161.96  E-value: 9.80e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  24 DIVIVVTLYDTIGIKFH-DFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISG 102
Cdd:cd17321   11 DVTIVNVALPTIARDLGaSPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 103 RVVAGFGGSGIESLAFVVGTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIilafc 182
Cdd:cd17321   91 RALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALL----- 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 183 ntsgephqkmwlpskikkimnydygellkasfwkntfevlvfkldmvgiilssagftllmLGLSFGGnnfpwnsgiiicf 262
Cdd:cd17321  166 ------------------------------------------------------------LARTFSG------------- 172

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 263 ftvgpillllfcaydfhflpllglhydnkrikplltwniasncgiftSSITGFLSCFAYELQSAYLVQLYQLVFKKKPTL 342
Cdd:cd17321  173 -----------------------------------------------AVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQ 205

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 343 ASIHLWELSIPAMIATMAIAYLNSKYGiIKPAIVFGVLCGIVGSGLFTLINGELS--QSIGYSILPGIAFGSIFQATLLS 420
Cdd:cd17321  206 AGLALLPLALAMLVAAPLAGRLADRFG-PRLVLVAGLLLTAVGLLLLALLGADSSvwLLLPGLVLLGLGLGLFATPLTNA 284

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 421 SQAQITsddpdfQNKFIEVTAFNSFAKSLGFAFGGNMGAMIFTASLKNQMRSSqlnipqftsvetllaysteHYDGPQSS 500
Cdd:cd17321  285 ALSSVP------KEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDS-------------------GVAALLSA 339

                        490       500
                 ....*....|....*....|....*....
gi 768883811 501 LSKFINTAIHDVFYCALGCYALSFFFGIF 529
Cdd:cd17321  340 AAAAFAAGFHLAFLVAAALALLAALLALL 368
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 35-422 1.17e-39

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 151.24  E-value: 1.17e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  35 IGIKFHDFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIE 114
Cdd:cd06179   24 IVADLGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 115 SLAFVVGTSIVREnHRGIMITALAISYVIAEGVGPFIGGAF--NEHLSWRWCFYINLPIGAFAFIILAFCNTSGEPHQKM 192
Cdd:cd06179  104 LGAAVASELVPNK-YRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIFNALALILLFFFYHPPPRPQLH 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 193 WLPSkikkimnydyGELLKasfwkntfevlvfKLDMVGIILSSAGFTLLMLGLSFGGNNFPWNSGIIICFFTVGPILLLL 272
Cdd:cd06179  183 GSST----------RQKLK-------------RLDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAHVIAPLVIGGVLLIA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 273 FCAYDFHFlpllglhydnkRIKPLLTWNIASNCGIFTSSIT-GFLSCFAYELQSAYLVQLYQLVFKKKPTLASIHLWELS 351
Cdd:cd06179  240 FGLYEWKG-----------TKDGLLPPRLLFRGRNFALILIvAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFG 308

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768883811 352 IPAMIATMAIAYLNSKYGIIKPAIVFGVLCGIVGSGLFTLIN-GELSQSIGYSILPGIAFGSIFQATLLSSQ 422
Cdd:cd06179  309 LGTLFGAILAGLLLTKIKHIKWQLVAGFVLFTAFLALLALITpDNKALAIAFSVLAGIGIGGPLVLAIVIVQ 380
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 56-471 1.02e-33

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 134.36  E-value: 1.02e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  56 NAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIVRENHRGIMIT 135
Cdd:cd17322   50 SAVSQPPYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGFASA 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 136 ALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAFCNTSGEphQKMWLPSKIKKIMNYDYGELLKAsfW 215
Cdd:cd17322  130 IPSLPYIITTWIGGNIAQAALPNSNWRWGYGMWAIILPLSSLPLVLCLLYMQ--RKARKDGEIKELKNQETEEQTGG--L 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 216 KNTFEVLVFKLDMVGIILSSAGFTLLMLGLSF-GGNNFPWNSGIIICFFTVGPILLLLFCAYDFHFLPllglhydnkriK 294
Cdd:cd17322  206 SQNLVKLFWKLDIFGVILLTAGLGLILVPLTLaGGAKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAK-----------Y 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 295 PLLTWNIASNCGIFTSSITGFLSCFAYELQSAYLVQLYQLVFKKKPTLASIHLWELSIPAMIATMAIAYLNSKYGIIKPA 374
Cdd:cd17322  275 PFLPFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVL 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 375 IVFGVLCGIVGSGLFTLINGE---LSQSIGYSILPGIAFGSIFQATLLSSQAQITsddpdfQNKFIEVTAFNSFAKSLGF 451
Cdd:cd17322  355 VIIGVPLYIVGMGLLIRYRGGsgsHGGIIGALILIGIGGGLFTYPVQVSVQASVS------HQEMAVVTALLLTVYSIGG 428

                        410       420
                 ....*....|....*....|
gi 768883811 452 AFGGNMGAMIFTASLKNQMR 471
Cdd:cd17322  429 AVGAAISGAIWTQTLPKKLL 448
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 24-181 2.16e-28

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 116.52  E-value: 2.16e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  24 DIVIVVTLYDTIGIKFH-DFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISG 102
Cdd:cd17503   11 DTTIVNVALPTIMGDLGaSLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIF 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768883811 103 RVVAGFGGSGIESLAFVVGTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:cd17503   91 RILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPL 169
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 41-390 6.67e-28

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 116.71  E-value: 6.67e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811   41 DFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVV 120
Cdd:TIGR00711  35 SLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFST 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  121 GTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAFcntsgephqkmwlpskikk 200
Cdd:TIGR00711 115 LLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFF------------------- 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  201 imnydygellkasFWKNTFEVLVFKLDMVGIILSSAGFTLLMLGLSFGGNNFPWNSGIIICFFTVGPILLLLFCAYDfhf 280
Cdd:TIGR00711 176 -------------ILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWE--- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  281 lpllgLHYDNKRIKPLLTWNIASNCGIFTSSITGFLScfayeLQSAYLV-QLYQLVFKKKPTLASIHLWELSIPAMIATM 359
Cdd:TIGR00711 240 -----LTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGL-----YGSFYLLpLYLQQVLGYTALQAGLHILPVGLAPMLSSP 309

                         330       340       350
                  ....*....|....*....|....*....|.
gi 768883811  360 AIAYLNSKYGIIKPAIVfGVLCGIVGSGLFT 390
Cdd:TIGR00711 310 IAGRMGDKIDPRKLVTI-GLILYAVGFYWRA 339
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
24-276 1.45e-24

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 105.06  E-value: 1.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  24 DIVIVVTLYDTIGIKFH-DFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISG 102
Cdd:COG2814   25 GIGIVLPALPLIAADLGaSPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 103 RVVAGFGGSGIESLAFVVGTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAFC 182
Cdd:COG2814  105 RFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 183 NTSGEPHQKMWLPSKIKKImnydygeLLKASFWKNTFEVLVFKLDMVGIILSSAGFTLLMLGLSfggnnfPWNSGIIICF 262
Cdd:COG2814  185 LPESRPAARARLRGSLREL-------LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS------ASAAGLLLAL 251

                        250
                 ....*....|....
gi 768883811 263 FTVGPILLLLFCAY 276
Cdd:COG2814  252 FGLGGVLGALLAGR 265
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 24-286 1.85e-24

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 103.35  E-value: 1.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  24 DIVIVVTLYDTIGIKFH-DFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISG 102
Cdd:COG0477   29 DFTIVNVALPSIAADLGaSSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAA 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 103 RVVAGFGGSGIESLAFVVGTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAFC 182
Cdd:COG0477  109 RALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 183 -NTSGEPHQKMWLPSKIKKIMNYDYGELLKASFWKNTFEVLVFKLDMVGIILSSAGFTLLMLGLSFGGNNFPWNSGIIIC 261
Cdd:COG0477  189 pESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLL 268

                        250       260
                 ....*....|....*....|....*
gi 768883811 262 FFTVGPILLLLFCAYDFHFLPLLGL 286
Cdd:COG0477  269 LLLLALLLALLLLLLLLLLLLLLAL 293
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 44-528 1.23e-17

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 86.26  E-value: 1.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811   44 NIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGtS 123
Cdd:pfam06609  79 NQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAGASPLFIG-E 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  124 IVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAfcntsgephqkMWL-PSKIKKIm 202
Cdd:pfam06609 158 LMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLII-----------IWYhPPSFAQL- 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  203 nydYGEllKASFWKNtfevlVFKLDMVGIILSSAGFTLLMLGLSFGGN-NFPWNSGIIICFFTVGPILLLLFCAYDFHfl 281
Cdd:pfam06609 226 ---HGK--KARKRDE-----LAKLDWIGIFLVIAGTSLFLLGVSWGGKpNNPWNSAKIIGLISSGAGSLVIFALYEVF-- 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  282 pllglhydNKRIKPLLTWNIASN-----CGIFTSSITGFLSCFAYELQSAYLVQLYQlvfkkkptlASIHLWE----LSI 352
Cdd:pfam06609 294 --------GKPEQPIIPPALFKDtrgfvCILIISSIMGAMHLCLTIIYPQQVINIFG---------SSLKNWEetawMSA 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  353 PAMIATMA-IAYLNSKYGIIKP---AIVFGVLCGIVGSGLFTLINGELSQS-IGYSILPGIAFGSIFQATLLssQAQITS 427
Cdd:pfam06609 357 TASFGTGAgVMILGNLFHLIRHirwQILVGALWLTAFLGAMSSINRDNKNAaIALSFFSGFVVAWAQDITML--LVQFIT 434

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  428 DDPDFQNKFIEVTAFNSFAKSLGFA----FGGNMGAMIFTASLKNQMRSSqlNIPQFTSVETLLAYSTEHYD------GP 497
Cdd:pfam06609 435 TDEDLGVAFAVVAAARPFAGSIFTAafisLYSNQYPKEIASHLSSALRGT--DFPQASFPSLLEAAKSGRIDavkalpGM 512

                         490       500       510
                  ....*....|....*....|....*....|.
gi 768883811  498 QSSLSKFINTAIHDVFYCAlgcYALSFFFGI 528
Cdd:pfam06609 513 TNEIAAVVSQAMADSYTAS---YANVYYFAM 540
MFS_1 pfam07690
Major Facilitator Superfamily;
45-181 3.10e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 83.24  E-value: 3.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811   45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSI 124
Cdd:pfam07690  34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 768883811  125 VRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:pfam07690 114 FPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLL 170
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 45-181 3.34e-17

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 83.40  E-value: 3.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGsGIESLAFVVGTSI 124
Cdd:cd17504   33 VSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGG-AVFPLAFALVREE 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768883811 125 VRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:cd17504  112 FPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPL 168
2_A_01_02 TIGR00880
Multidrug resistance protein;
46-181 9.43e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 74.22  E-value: 9.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811   46 GWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIV 125
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 768883811  126 RENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAF 136
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 49-182 2.42e-15

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 77.62  E-value: 2.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  49 VTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIVREN 128
Cdd:cd17323   40 VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPE 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768883811 129 HRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAFC 182
Cdd:cd17323  120 ERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLF 173
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 43-181 3.14e-15

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 77.20  E-value: 3.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  43 GNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGT 122
Cdd:cd17324   34 AQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 768883811 123 SIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:cd17324  114 DLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWR 172
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 47-181 1.51e-13

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 72.22  E-value: 1.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  47 WLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGieslAFVVGTSIVR 126
Cdd:cd17320   38 LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAA----GSVVARAIVR 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 768883811 127 ENHRGI----MITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:cd17320  114 DLYSGAelakIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLL 172
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
45-178 4.90e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 70.67  E-value: 4.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSI 124
Cdd:COG2271   47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEW 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768883811 125 VRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFII 178
Cdd:COG2271  127 FPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL 180
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 45-181 1.41e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 69.14  E-value: 1.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSI 124
Cdd:cd17325   33 IGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADI 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768883811 125 VRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:cd17325  113 APPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALL 169
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 26-286 2.00e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 68.99  E-value: 2.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  26 VIVVTLYDTIGIKFHDFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVV 105
Cdd:cd06174   14 LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 106 AGFGGSGIESLAFVVGTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHL--SWRWCFYINLPIGAFAFIILAFCN 183
Cdd:cd06174   94 LGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLVV 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 184 TSGEPHQKMWLPSKIKKIMNYDYGELLKAS-FWKNTFevLVFKLDMVGIILSSAGFTLLMLGLSFGGNNFPWNSGIIICF 262
Cdd:cd06174  174 PDPPESARAKNEEASSKSVLKLLKRVLKNPgLWLLLL--AIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLA 251

                        250       260
                 ....*....|....*....|....
gi 768883811 263 FTVGPILLLLFCAYDFHFLPLLGL 286
Cdd:cd06174  252 GALGSLLLGLLSDRLIGRKPLLLI 275
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 44-181 2.64e-12

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 68.37  E-value: 2.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  44 NIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTS 123
Cdd:cd17474   35 QVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGD 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 124 IVRENHRG--IMITALAISyvIAEGVGPFIGGAFNEHlSWRWCFYINLPIGAFAFIILAF 181
Cdd:cd17474  115 LFEGGERAkaMGLYEAALG--LGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAILF 171
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 50-181 5.33e-12

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 67.41  E-value: 5.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811   50 TGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGieslAFVVGTSIVRENH 129
Cdd:TIGR00710  47 TLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASA----GSVISQALVRDIY 122

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 768883811  130 RG----IMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYInLPIGAFAFIILAF 181
Cdd:TIGR00710 123 PGeelsRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF-LSLAGILLSALIF 177
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 43-178 6.96e-11

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 63.82  E-value: 6.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  43 GNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAF-VVG 121
Cdd:cd17476   33 NQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMaLLG 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768883811 122 TSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFII 178
Cdd:cd17476  113 RTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVA 169
PRK10504 PRK10504
putative transporter; Provisional
 48-179 1.03e-10

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 63.98  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  48 LVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIV-R 126
Cdd:PRK10504  50 VIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVpR 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 768883811 127 ENHRGIMiTALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLP---IGAFAFIIL 179
Cdd:PRK10504 130 EQYMAAM-TFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPvgiIGAIATLML 184
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 45-181 2.36e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 62.21  E-value: 2.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSI 124
Cdd:cd17325  237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768883811 125 VRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:cd17325  317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
45-181 8.67e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 60.66  E-value: 8.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGieslAFVVGTSI 124
Cdd:COG2223   42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGG----SFAVGIAL 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768883811 125 VRE----NHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:COG2223  118 VSKwfppDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWL 178
PRK14995 PRK14995
SmvA family efflux MFS transporter;
47-171 2.30e-09

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 59.74  E-value: 2.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  47 WLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGI--ESLAfVVGTSI 124
Cdd:PRK14995  45 WIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIvpATLA-GIRATF 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 768883811 125 VRENHRGImitALAISYVIAEG---VGPFIGGAFNEHLSWRWCFYINLPI 171
Cdd:PRK14995 124 TEEKQRNM---ALGVWAAVGSGgaaFGPLVGGILLEHFYWGSVFLINVPI 170
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 24-265 7.63e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 57.61  E-value: 7.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  24 DIVIVVTLYDTIGIKFHDFGNIGWLVTGYALSNAVFM---LLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLI 100
Cdd:cd17316   14 DFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPigaLLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 101 SGRVVAGFGGSGIESLAFVVGTSIVRENHRGIMITAL----AISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAF 176
Cdd:cd17316   94 VLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLqsgwALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLAL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 177 ---------IILAFCNTSGEPHQKMWLPSKIKKIMNYDYGELLKASFWKNTFEVLVFKL-----DMVG----IILSSAGF 238
Cdd:cd17316  174 llrrrtlllILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIagllsDRIGrkktLVIGLILS 253

                        250       260
                 ....*....|....*....|....*..
gi 768883811 239 TLLMLGLSFGGNNFPWNSGIIICFFTV 265
Cdd:cd17316  254 GILALPLFYLLSGSPTLLLLLLFILSF 280
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
45-163 1.58e-08

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 56.81  E-value: 1.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGsgieSLAFVVGTSI 124
Cdd:COG2807   55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI----AVGNVLLPGL 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 768883811 125 VRE---NHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRW 163
Cdd:COG2807  131 IKRwfpDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRG 172
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
50-177 6.05e-08

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 54.92  E-value: 6.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  50 TGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGieslAFVVGTSIVRE-- 127
Cdd:PRK11102  33 SAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAA----ASVVINALMRDmf 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 768883811 128 --NHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYInlpIGAFAFI 177
Cdd:PRK11102 109 pkEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWV---LALAAIL 157
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 45-181 1.69e-07

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 53.37  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGgsGIESLAFVVGTSI 124
Cdd:cd17472   34 IGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG--AISSVVMALLADL 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768883811 125 VRENHR----GIMITALAISYVIAEGVGPFIGGafneHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:cd17472  112 TREENRtkamALIGASIGIAFAISMVLGPLLAA----HLGVSGLFLITAILSLVSLLILLF 168
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
41-181 2.68e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.95  E-value: 2.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  41 DFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKEC--LMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAF 118
Cdd:COG2271  214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlvLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768883811 119 VVGTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:COG2271  294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 45-273 2.92e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.60  E-value: 2.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSI 124
Cdd:cd17489   33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADI 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 125 VRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAFCNTSGEPHQKmwlpskikkimny 204
Cdd:cd17489  113 IPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAE------------- 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 205 dyGELLKASFWKNTFEVLVFkLDMVGIILSSAGFTLLMLGLS-FGGNNFPWNSGIiicFFTVGPILLLLF 273
Cdd:cd17489  180 --EAEAGTRAFRRLVEKKVL-PPALILFLASIAYGAISTFLPlYAAERGISNAGL---FFTVYAIALLLS 243
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
45-181 3.45e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 52.55  E-value: 3.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSI 124
Cdd:COG0738   45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL 124

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 125 VRENHRGIMiTALAISYVIAEGVGPFIGGAF---NEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:COG0738  125 GPETAASRL-NLLHAFFSLGALLGPLLGGLLillGLSLSWHLPYLILAVLLLLLALLFLR 183
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 45-182 5.08e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 51.80  E-value: 5.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSI 124
Cdd:cd17319   40 YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEW 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 768883811 125 VRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYInlpIGAFAFIILAFC 182
Cdd:cd17319  120 FPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII---EGLLGLLLAVLW 174
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 45-181 5.11e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 51.97  E-value: 5.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811   45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSI 124
Cdd:TIGR00895  54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEY 133

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 768883811  125 VRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:TIGR00895 134 APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMR 190
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 61-180 1.57e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 50.28  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  61 LLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIVRENHRGIMITALAIS 140
Cdd:cd17365   52 LLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCG 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 768883811 141 YVIAEGVGPFIGGAFNEHLSWRWCFYinlpIGAFAFIILA 180
Cdd:cd17365  132 YPLGAALGGFLAAALIPAFGWRSVFL----LGGVPPLILL 167
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 46-181 1.76e-06

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 50.26  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  46 GWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIV 125
Cdd:cd17359   39 GLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVA 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768883811 126 RENHRGIM--------ITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLpIGAFAFIILAF 181
Cdd:cd17359  119 PAEIRGRLvslnqlmiVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEA-IPAILFLLGML 181
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 45-181 1.79e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 50.26  E-value: 1.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIeslaFVVGTSI 124
Cdd:cd17473   37 VPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGI----MTLATAL 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768883811 125 V--------RENHRGIMITALAISYVIAegvgPFIGGAFNEhLSWRWCFYINLpigaFAFIILAF 181
Cdd:cd17473  113 IgdyfegeeRAKMLGLQSAAMSLGGVVF----LLLGGALAE-IGWRAPFLVYL----LALPVLIL 168
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 51-167 2.19e-06

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 49.96  E-value: 2.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  51 GYALSNAVFMLL-----WGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFG-GSGIESLAFVVGTSi 124
Cdd:PRK11551  53 GWAFSAGILGLLpgallGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGlGGALPNLIALTSEA- 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 768883811 125 VRENHRGimiTALAISY-------VIAEGVGPFIGGafneHLSWRWCFYI 167
Cdd:PRK11551 132 VGPRLRG---TAVSLMYcgvpfggALASVIGVLAAG----DAAWRHIFYV 174
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 57-181 2.28e-06

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 49.96  E-value: 2.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  57 AVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFgGSGIESL-AFVVGTSIVRENHRGIMIT 135
Cdd:cd17360   49 AVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGL-GVGIASMtVPLYIAEAAPPRIRGRLVT 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 768883811 136 ALAISYVIAEGVGPFIGGAFNE-HLSWRWCFYINLPIGAFAFIILAF 181
Cdd:cd17360  128 INVLFITGGQFVAYVINGAFSYlPGGWRWMLGLAAVPAVLQFIGLLF 174
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 46-256 3.27e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 49.54  E-value: 3.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  46 GWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIV 125
Cdd:cd17328   37 GLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLF 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 126 RENHRGIMITALAISYVIAEGVGPFIGGAFNEH-LSWRWCFYINLPIGAFAFIILAFcnTSGEPHQKMWLPSKIKKIMNY 204
Cdd:cd17328  117 PKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLL--FVREPPRGAAEGGVMAKSTAT 194

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 768883811 205 DYGELLKASFWKNTFevlvfkldmvgiILSSAGFTllmlGLSFGGNNFPWNS 256
Cdd:cd17328  195 SFLADLKALAKNPSF------------ILSTLGFT----AVSFVTGALAFWA 230
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 46-185 3.74e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 49.11  E-value: 3.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  46 GWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIV 125
Cdd:cd17315   37 GLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIA 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768883811 126 RENHRGIMITALAISYVIAEGVGPFIGGAF--NEHLSWRWCFYINLPIGAFAFIILAFCNTS 185
Cdd:cd17315  117 PAKIRGALGTLNQLMITFGILLAYLLGLALslSPPGWWRLMFALAAVPALLQLLLMFFLPES 178
Sugar_tr pfam00083
Sugar (and other) transporter;
45-182 4.91e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 49.19  E-value: 4.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811   45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMAT---LISGRVVAGFGGSGIESLAFVVG 121
Cdd:pfam00083  48 SGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIGVGGASVLAPMYI 127

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768883811  122 TSIVRENHRGIMIT----ALAISYVIAEGVGpFIGGAFNEHLSWRWCFYINLPIGAFAFIILAFC 182
Cdd:pfam00083 128 SEIAPKKLRGALGSlyqlAITFGILLAYIFG-LGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFL 191
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 27-182 6.10e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 48.34  E-value: 6.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  27 IVVTLYDTIGIKFHDFGN----IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISG 102
Cdd:cd17330   14 IVFPVLPFYVREFNKLGAsgyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 103 RVVAGFGGSGIeSLAFVVGTSIVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYInlpIGAFAFIILAFC 182
Cdd:cd17330   94 RFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV---AAALALLNLVLV 169
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 61-182 1.76e-05

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 47.32  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811   61 LLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIVRENHRGIMIT----A 136
Cdd:TIGR00898 145 FVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTliqvF 224

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 768883811  137 LAISYVIAEGVGPFIggafnehLSWRWC-FYINLPigAFAFIILAFC 182
Cdd:TIGR00898 225 FSLGLVLLPLVAYFI-------PDWRWLqLAVSLP--TFLFFLLSWF 262
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
49-211 1.84e-05

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 47.24  E-value: 1.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  49 VTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGgsgiesLAFV--VGTSIVR 126
Cdd:PRK15402  54 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIG------LCFIgaVGYAAIQ 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 127 ENHR---GIMITAL-AISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIIL--AFCNTSGEPHQKMWLPSkikk 200
Cdd:PRK15402 128 ESFEeadAIKITALmANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLwrAMPETAGRVGEKLSLKE---- 203

                        170
                 ....*....|.
gi 768883811 201 iMNYDYGELLK 211
Cdd:PRK15402 204 -LGRDYKLVLK 213
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 44-161 2.14e-05

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 47.28  E-value: 2.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811   44 NIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTS 123
Cdd:TIGR01299 203 GKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAE 282

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 768883811  124 IVRENHRGIMITALAISYViaegvgpfIGGAFNEHLSW 161
Cdd:TIGR01299 283 FLAQEKRGEHLSWLCMFWM--------IGGIYAAAMAW 312
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 46-200 2.73e-05

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 46.56  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811   46 GWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSN---SMATLISGRVVAGFGGSGIESLAFVVGT 122
Cdd:TIGR00879  74 GLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAfalSVEMLIVGRVLLGIGVGIASALVPMYLS 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  123 SIVRENHRGIMITALAISYVIAEGVGPFIGGA---FNEHLSWRWCFYINLPIGAFAFIILAFCntsgePHQKMWLPSKIK 199
Cdd:TIGR00879 154 EIAPKALRGALTSLYQLAITFGILVAYGFGSGkvsLNNTLGWRIPLGLQLIPAGLLFLGLFFL-----PESPRWLVGKGR 228


                  .
gi 768883811  200 K 200
Cdd:TIGR00879 229 V 229
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 48-176 1.14e-04

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 44.69  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  48 LVTGYALSNAVFM------LLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSG--IESLAFV 119
Cdd:PRK03893  54 TVQAASLISAAFIsrwfggLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGeyGSSATYV 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 120 VGTSIVRENHR--GIMITALAISYVIAEGVGPFIGgafnEHLSWRWCFYIN-LPIgAFAF 176
Cdd:PRK03893 134 IESWPKHLRNKasGFLISGFSIGAVVAAQVYSLVV----PVWGWRALFFIGiLPI-IFAL 188
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
46-182 1.26e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.49  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  46 GWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLI-SALSNSMATLISGRVVAGFGGSGIESLAFVVGTSI 124
Cdd:COG2223  244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLlALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDI 323

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 768883811 125 VRENHRGIMITALAISYVIAEGVGPFIGGAFNEHL-SWRWCFYINLPIGAFAFIILAFC 182
Cdd:COG2223  324 FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLL 382
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 46-167 1.34e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 44.22  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  46 GWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFgGSGIEslaFVVGTS-- 123
Cdd:cd17371   37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGL-GFGGE---WAAGAAlm 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 768883811 124 --IVRENHR----GIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYI 167
Cdd:cd17371  113 aeYVPARHRgkalGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLL 162
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 61-181 1.47e-04

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 44.31  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  61 LLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIVRENHRGIMIT--ALA 138
Cdd:cd17437   50 LAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSfpEIF 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 768883811 139 ISYVIAEG-VGPFIGGAFNEHLSWRwcfyINLPIGAFAFIILAF 181
Cdd:cd17437  130 INIGILLGyVSNYAFSGLPLHVGWR----LMLGVGAVPSLFLAI 169
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 45-181 2.94e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 43.11  E-value: 2.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSI 124
Cdd:cd17362   41 SGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAET 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 768883811 125 VRENHRGIMITALAISYVIAEGVGPFIGGAF-NEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:cd17362  121 SPSHIRGLLVSLKELFIVLGILLGYVSGYAFaDVVGGWRYMYGLAAPPALLLGIGMWF 178
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
41-144 3.15e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.04  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  41 DFGNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVV 120
Cdd:COG2814  241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320

                         90       100
                 ....*....|....*....|....
gi 768883811 121 GTSIVRENHRGIMITALAISYVIA 144
Cdd:COG2814  321 VAELAPPEARGRASGLYNSAFFLG 344
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 53-182 4.61e-04

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 42.65  E-value: 4.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  53 ALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMAT------LISGRVVAGF--GGSGIESLAFVVGTSI 124
Cdd:cd17386   40 SIPPLFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYFTTvpsvwwFYLSAIPLALfgGFTAFLSASFAYISDI 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 768883811 125 VRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAFC 182
Cdd:cd17386  120 SSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIALLYILFF 177
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
45-154 4.79e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.58  E-value: 4.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALS--NSMATLISGRVVAGFGGSGIESLAFVVGT 122
Cdd:COG2211  266 VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLA 345

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 768883811 123 SIV-------RENHRGIMITALAISYVIAEGVGPFIGGA 154
Cdd:COG2211  346 DVVdydewktGRRREGLYFGIFTFAIKLGQALAGALAGL 384
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 45-178 5.90e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 42.15  E-value: 5.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSI 124
Cdd:cd17324  236 IIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 768883811 125 VREnHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFII 178
Cdd:cd17324  316 APE-ARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 43-158 6.87e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 42.24  E-value: 6.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  43 GNIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGF-GGSGIESLAFV-- 119
Cdd:cd17388   38 THYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGItGATGAVAAAYIad 117

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 768883811 120 VGTSIVRENHRGIMITALAISYVIaegvGPFIGGAFNEH 158
Cdd:cd17388  118 VTPPEQRARNFGLLGAAFGLGFIA----GPALGGLLGEI 152
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 45-181 6.94e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.22  E-value: 6.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSI 124
Cdd:cd06173  246 YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLR 325

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 768883811 125 VRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYinlpIGAFAFIILAF 181
Cdd:cd06173  326 VPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL----LAGALLLLAAL 378
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 61-181 7.52e-04

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 42.18  E-value: 7.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  61 LLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIVRENHRGIMITALAIS 140
Cdd:cd17358   59 LLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLL 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 768883811 141 YVIAEGVGPFIGGafneHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:cd17358  139 VNIGILLGYVLGS----FLPWRTLALIGAIPPVVFLILLFF 175
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 44-181 8.36e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 8.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  44 NIGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTS 123
Cdd:cd17489  228 NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVD 307

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 768883811 124 IVRENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:cd17489  308 LVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
312-465 1.43e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.04  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 312 ITGFLSCFAYELQSAYLVQLYQLVFKKKPTLASIHLWELSIPAMIATMAIAYLNSKYGIIKPAIVFGVLCGIVGSGLFTL 391
Cdd:COG2211  235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFL 314

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768883811 392 INGELSQSIGYSILPGIAFGsIFQATLLSSQAQITSDDPDFQNKFIE--VTAFNSFAKSLGFAFGGNMGAMIFTAS 465
Cdd:COG2211  315 GPGNLWLLLVLAALAGIGLG-AILVLPWAMLADVVDYDEWKTGRRREglYFGIFTFAIKLGQALAGALAGLLLALF 389
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
62-181 1.77e-03

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 40.97  E-value: 1.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  62 LWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGfggsgiESLAFV--VGTSIVRE---NHRGIMITA 136
Cdd:PRK15403  70 LLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQG------TSICFIatVGYVTVQEafgQTKGIKLMA 143

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 768883811 137 LAISYV-IAEGVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:PRK15403 144 IITSIVlVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLL 189
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 45-165 2.35e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 40.30  E-value: 2.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAfvvGTSI 124
Cdd:cd17475   33 VGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGG---GRAI 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 768883811 125 VR---ENHRG----IMITALAISYVIAEGVGPFIGgafnEHLSWRWCF 165
Cdd:cd17475  110 MRwfpPRERGlamgIRQTGVPLGGALAAALLPPLA----LHYGWRAAF 153
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 46-167 2.76e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 40.33  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  46 GWLVTGYALSNAVFMLLW-------GRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGieSLAF 118
Cdd:cd17355   34 GWSRAVISLAFTVGLLAFglaqpfvGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAG--TLAA 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 768883811 119 VVGTSIVR---ENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYI 167
Cdd:cd17355  112 VAFATVAAwwfERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLV 163
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 61-161 4.45e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 39.52  E-value: 4.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  61 LLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIVRENHRGIMITALAIS 140
Cdd:cd17438   52 FIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMF 131

                         90       100
                 ....*....|....*....|.
gi 768883811 141 YViaegvgpfIGGAFNEHLSW 161
Cdd:cd17438  132 WM--------IGGLYASAMAW 144
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 54-161 5.45e-03

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 39.24  E-value: 5.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  54 LSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIVRENHRGIM 133
Cdd:cd17439   45 LGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEH 124

                         90       100
                 ....*....|....*....|....*...
gi 768883811 134 ITALAISYVIAEGVGPFIGGAFNEHLSW 161
Cdd:cd17439  125 LSWLCMFWMIGGIYASAMAWAIIPHYGW 152
emrD PRK11652
multidrug transporter EmrD;
51-181 6.16e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 39.12  E-value: 6.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  51 GYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVV------GTSI 124
Cdd:PRK11652  51 AYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLprdlyeGTQL 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811 125 VREN---HRGIMITALaisyviaegVGPFIGGAFNEHLSWRWCFYINLPIGAFAFIILAF 181
Cdd:PRK11652 131 RHANsllNMGILVSPL---------LAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMAR 181
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 45-181 6.90e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 38.79  E-value: 6.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAG-FGGSGIESLAFVVGTS 123
Cdd:cd17312   40 LGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGlFQSMGWPPCVKLLGNW 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 768883811 124 IVREnHRGIMITALAISYVIAEGVGPFIGGAFNEHLSWRWCFYINlPIGAFAFIILAF 181
Cdd:cd17312  120 FSKK-ERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVP-GIVGLVVAIILF 175
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 46-161 6.92e-03

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 39.13  E-value: 6.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  46 GWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIESLAFVVGTSIV 125
Cdd:cd17440   37 GWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVL 116

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 768883811 126 RENHRGIMITALAISYVIAEGVGPFIGGAFNEHLSW 161
Cdd:cd17440  117 AREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW 152
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 45-157 7.81e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 38.69  E-value: 7.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768883811  45 IGWLVTGYALSNAVFMLLWGRLAEILGTKECLMISVIVFEIGSLISALSNSMATLISGRVVAGFGGSGIeslaFVVGTS- 123
Cdd:cd17477   33 IGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGL----FVVSESw 108

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 768883811 124 ---IVRENHRGIMITALAISYVIAEGVGPFIGGAFNE 157
Cdd:cd17477  109 lnaLATNENRGRVLGLYSTVLGLGFALGPLLLALVGT 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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