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Conserved domains on  [gi|768018525|ref|XP_011527389|]
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mRNA export factor RAE1 isoform X2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-335 3.17e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 3.17e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525  39 DDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQDsGQTIpKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSN 118
Cdd:COG2319  120 TGAVRSVAFSPD---GKTLASGSADGTVRLWDLAT-GKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 119 QAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErcycaDVIYPMA--------VVATAE 189
Cdd:COG2319  195 KLLRtLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS-----GSVRSVAfspdgrllASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 190 RGLIVYQLENqpsefRRIESPLKHQH---RCVAIFKDKQNkptgFALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtn 266
Cdd:COG2319  268 GTVRLWDLAT-----GELLRTLTGHSggvNSVAFSPDGKL----LASGSDDGTVRLWDLATGKLLR---TLTGHTG---- 331

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768018525 267 tsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319  332 --------AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-335 3.17e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 3.17e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525  39 DDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQDsGQTIpKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSN 118
Cdd:COG2319  120 TGAVRSVAFSPD---GKTLASGSADGTVRLWDLAT-GKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 119 QAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErcycaDVIYPMA--------VVATAE 189
Cdd:COG2319  195 KLLRtLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS-----GSVRSVAfspdgrllASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 190 RGLIVYQLENqpsefRRIESPLKHQH---RCVAIFKDKQNkptgFALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtn 266
Cdd:COG2319  268 GTVRLWDLAT-----GELLRTLTGHSggvNSVAFSPDGKL----LASGSDDGTVRLWDLATGKLLR---TLTGHTG---- 331

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768018525 267 tsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319  332 --------AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-335 1.92e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 1.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525  40 DSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQdsGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQ 119
Cdd:cd00200   10 GGVTCVAFSPD---GKLLATGSGDGTIKVWDLE--TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 120 AIQ-IAQHDAPVKTIHWIkaPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErCYCADVIYP----MAVVATAERGLIV 194
Cdd:cd00200   85 CVRtLTGHTSYVSSVAFS--PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHT-DWVNSVAFSpdgtFVASSSQDGTIKL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 195 YQLENqpseFRRIESPLKHQH--RCVAIFKDKQNkptgFALGSIEGRVAIHyinppnpakDNFTFKCHRSNGTNTSapqd 272
Cdd:cd00200  162 WDLRT----GKCVATLTGHTGevNSVAFSPDGEK----LLSSSSDGTIKLW---------DLSTGKCLGTLRGHEN---- 220

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768018525 273 iyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:cd00200  221 --GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-114 1.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.61e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 768018525    85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWD 114
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
85-114 8.68e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 8.68e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 768018525   85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWD 114
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
39-335 3.17e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 3.17e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525  39 DDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQDsGQTIpKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSN 118
Cdd:COG2319  120 TGAVRSVAFSPD---GKTLASGSADGTVRLWDLAT-GKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 119 QAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErcycaDVIYPMA--------VVATAE 189
Cdd:COG2319  195 KLLRtLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS-----GSVRSVAfspdgrllASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 190 RGLIVYQLENqpsefRRIESPLKHQH---RCVAIFKDKQNkptgFALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtn 266
Cdd:COG2319  268 GTVRLWDLAT-----GELLRTLTGHSggvNSVAFSPDGKL----LASGSDDGTVRLWDLATGKLLR---TLTGHTG---- 331

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768018525 267 tsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319  332 --------AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 COG2319
WD40 repeat [General function prediction only];
32-335 6.56e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 6.56e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525  32 IEVTSSPDDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVqdSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAK 111
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPD---GRLLASASADGTVRLWDL--ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 112 MWDLSSNQAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErcycaDVIYPMA------- 183
Cdd:COG2319  146 LWDLATGKLLRtLTGHSGAVTSVAF--SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT-----GAVRSVAfspdgkl 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 184 -VVATAERGLIVYQLENqpsefRRIESPLKHQH---RCVAIFKDkqnkptG--FALGSIEGRVAIHYINPPNPAKdnfTF 257
Cdd:COG2319  219 lASGSADGTVRLWDLAT-----GKLLRTLTGHSgsvRSVAFSPD------GrlLASGSADGTVRLWDLATGELLR---TL 284

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768018525 258 KCHRSngtntsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319  285 TGHSG------------GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-335 1.92e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 1.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525  40 DSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQdsGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQ 119
Cdd:cd00200   10 GGVTCVAFSPD---GKLLATGSGDGTIKVWDLE--TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 120 AIQ-IAQHDAPVKTIHWIkaPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErCYCADVIYP----MAVVATAERGLIV 194
Cdd:cd00200   85 CVRtLTGHTSYVSSVAFS--PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHT-DWVNSVAFSpdgtFVASSSQDGTIKL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 195 YQLENqpseFRRIESPLKHQH--RCVAIFKDKQNkptgFALGSIEGRVAIHyinppnpakDNFTFKCHRSNGTNTSapqd 272
Cdd:cd00200  162 WDLRT----GKCVATLTGHTGevNSVAFSPDGEK----LLSSSSDGTIKLW---------DLSTGKCLGTLRGHEN---- 220

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768018525 273 iyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:cd00200  221 --GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
38-160 1.19e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 1.19e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525  38 PDDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVqDSGQTIpKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSS 117
Cdd:COG2319  287 HSGGVNSVAFSPD---GKLLASGSDDGTVRLWDL-ATGKLL-RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 768018525 118 NQAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRS 160
Cdd:COG2319  362 GELLRtLTGHTGAVTSVAF--SPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
32-168 7.03e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 7.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525  32 IEVTSSPDDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQdsGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAK 111
Cdd:COG2319  239 LRTLTGHSGSVRSVAFSPD---GRLLASGSADGTVRLWDLA--TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 768018525 112 MWDLSSNQAIQIAQ-HDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQ 168
Cdd:COG2319  314 LWDLATGKLLRTLTgHTGAVRSVAF--SPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 85-335 1.28e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 1.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525  85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIkaPNYSCVMTGSWDKTLKFWDTrssnp 163
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLrTLKGHTGPVRDVAAS--ADGTYLASGSSDKTIRLWDL----- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 164 mmvlqlpercycadviypmavvataerglivyqleNQPSEFRRIESplkHQH--RCVAIFKDKQnkptgFALGSIEGRVA 241
Cdd:cd00200   81 -----------------------------------ETGECVRTLTG---HTSyvSSVAFSPDGR-----ILSSSSRDKTI 117

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 242 IHYINPPNPAKdnFTFKCHRSngtntsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISAC 321
Cdd:cd00200  118 KVWDVETGKCL--TTLRGHTD------------WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSV 183

                        250
                 ....*....|....
gi 768018525 322 CFNHNGNIFAYASS 335
Cdd:cd00200  184 AFSPDGEKLLSSSS 197
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-157 6.96e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 6.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525  39 DDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVqDSGQTIpkaQQM--HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLS 116
Cdd:cd00200  177 TGEVNSVAFSPD---GEKLLSSSSDGTIKLWDL-STGKCL---GTLrgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 768018525 117 SNQAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWD 157
Cdd:cd00200  250 TGECVQtLSGHTNSVTSLAW--SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
57-335 2.81e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 2.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525  57 LIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHW 135
Cdd:COG2319   49 ARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 136 ikAPNYSCVMTGSWDKTLKFWDTRssnpmmvlqlpercycadviypmavvataerglivyqlenqpsefrriesplkhqh 215
Cdd:COG2319  129 --SPDGKTLASGSADGTVRLWDLA-------------------------------------------------------- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768018525 216 rcvaifkdkqnkpTGFALGSIEGrvaihyinppnpakdnftfkcHRSngtntsapqdiyAVNGIAFHPVHGTLATVGSDG 295
Cdd:COG2319  151 -------------TGKLLRTLTG---------------------HSG------------AVTSVAFSPDGKLLASGSDDG 184

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 768018525 296 RFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
Cdd:COG2319  185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-114 1.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.61e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 768018525    85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWD 114
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
85-114 8.68e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 8.68e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 768018525   85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWD 114
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 126-157 3.58e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 3.58e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 768018525   126 HDAPVKTIHWikAPNYSCVMTGSWDKTLKFWD 157
Cdd:smart00320  11 HTGPVTSVAF--SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
126-157 5.24e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 5.24e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 768018525  126 HDAPVKTIHWikAPNYSCVMTGSWDKTLKFWD 157
Cdd:pfam00400  10 HTGSVTSLAF--SPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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