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Conserved domains on  [gi|768011265|ref|XP_011525648|]
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protein fuzzy homolog isoform X6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fuzzy super family cl40581
protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector ...
 1-317 3.00e-142

protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector that controls multiple cellular processes during development. PCP signalling is an evolutionarily conserved pathway by which directional information regarding polarized cell movement is provided to cells. The PCP signalling axis involves PCP core and PCP effector genes, which are activated consecutively to govern orientated cell migration and the establishment of cytoskeletal structures. Dishevelled (Dvl in mammals or Dsh in Drosophila) and Fuz (or fuzzy in Drosophila) are two representative PCP core and effector genes, respectively. PCP regulates mammalian nervous system development; Fuz-null mutant mice display neural tube defects due to failure of directional cell motility and cell fusion.


The actual alignment was detected with superfamily member cd21091:

Pssm-ID: 477403 [Multi-domain]  Cd Length: 401  Bit Score: 407.12  E-value: 3.00e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265   1 MVFGAMVLLVGLEELTNIRNVERLKKDLRASYCLIDSFLGDSELIGDLTQCVDCVIPPEGSLLQEALSGFAEAAGTTFVS 80
Cdd:cd21091   86 NVFGAMVLLIGLDELTNITNVERLKKDLRACYPLIDSFLGNSELMGDLTQCVDCVIPPEGAALQECLDGFAEAAESTFGC 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265  81 LVVSGRVVAATEGWWRLGTPEAVLLPWLVGSLPPQTARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLLCGPSPPLSQLY 160
Cdd:cd21091  166 LVVGGRVVVATEKWWRLDTQELVLLPWLVNSLPPTQARDYPVYLPHGSPTVPHRLLTFQLLSGVEVCVLCGPEPSLQQVQ 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265 161 PQLLERWWQPLLDPLRACLPLGPRALPSGFPLHTDILGLLLLHLELKRCLFTVEPLGDKA----EPSPEQRRRLLRNFYT 236
Cdd:cd21091  246 RELVERFWRPLLDPLRACLRLVPRALPLGVPLDSGVLGLLLINRETRRSLFTVQPSEDSArkrmSLSDEQRRDALRSFYT 325

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265 237 LVTSTHFPPEPGPPEKTEDEVY-QAQLPRACYLVLGTeepgtgVRLVALQLGLRRLLLLLSPQSPTHGLRSLATHTLHAL 315
Cdd:cd21091  326 LVADRYFPPETGPDENTTTTVHpFSHLPRECYVVTKS------HKCYAIQTSQYQLFLLFSPAVPTHALRSLATRTLQAL 399


                 ..
gi 768011265 316 TP 317
Cdd:cd21091  400 TK 401
 
Name Accession Description Interval E-value
Fuzzy cd21091
protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector ...
 1-317 3.00e-142

protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector that controls multiple cellular processes during development. PCP signalling is an evolutionarily conserved pathway by which directional information regarding polarized cell movement is provided to cells. The PCP signalling axis involves PCP core and PCP effector genes, which are activated consecutively to govern orientated cell migration and the establishment of cytoskeletal structures. Dishevelled (Dvl in mammals or Dsh in Drosophila) and Fuz (or fuzzy in Drosophila) are two representative PCP core and effector genes, respectively. PCP regulates mammalian nervous system development; Fuz-null mutant mice display neural tube defects due to failure of directional cell motility and cell fusion.


Pssm-ID: 411043 [Multi-domain]  Cd Length: 401  Bit Score: 407.12  E-value: 3.00e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265   1 MVFGAMVLLVGLEELTNIRNVERLKKDLRASYCLIDSFLGDSELIGDLTQCVDCVIPPEGSLLQEALSGFAEAAGTTFVS 80
Cdd:cd21091   86 NVFGAMVLLIGLDELTNITNVERLKKDLRACYPLIDSFLGNSELMGDLTQCVDCVIPPEGAALQECLDGFAEAAESTFGC 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265  81 LVVSGRVVAATEGWWRLGTPEAVLLPWLVGSLPPQTARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLLCGPSPPLSQLY 160
Cdd:cd21091  166 LVVGGRVVVATEKWWRLDTQELVLLPWLVNSLPPTQARDYPVYLPHGSPTVPHRLLTFQLLSGVEVCVLCGPEPSLQQVQ 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265 161 PQLLERWWQPLLDPLRACLPLGPRALPSGFPLHTDILGLLLLHLELKRCLFTVEPLGDKA----EPSPEQRRRLLRNFYT 236
Cdd:cd21091  246 RELVERFWRPLLDPLRACLRLVPRALPLGVPLDSGVLGLLLINRETRRSLFTVQPSEDSArkrmSLSDEQRRDALRSFYT 325

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265 237 LVTSTHFPPEPGPPEKTEDEVY-QAQLPRACYLVLGTeepgtgVRLVALQLGLRRLLLLLSPQSPTHGLRSLATHTLHAL 315
Cdd:cd21091  326 LVADRYFPPETGPDENTTTTVHpFSHLPRECYVVTKS------HKCYAIQTSQYQLFLLFSPAVPTHALRSLATRTLQAL 399


                 ..
gi 768011265 316 TP 317
Cdd:cd21091  400 TK 401
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 74-169 1.02e-15

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 71.49  E-value: 1.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265   74 AGTTFVSLVVSGRVVAATEGWW-RLGTPEAVLLPWLVGSLPPQT--ARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLLC 150
Cdd:pfam19037   1 KSLLFALLLVGGKLVAAYRPRWaSLHPSDLLLLFLLVQSSSPFKslELWIPICLPKFNPGVLHRYISFLGDINLCLLLLS 80

                          90
                  ....*....|....*....
gi 768011265  151 GPSPPLsQLYPQLLERWWQ 169
Cdd:pfam19037  81 GDKPAF-FELSLLDDRFWL 98
 
Name Accession Description Interval E-value
Fuzzy cd21091
protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector ...
 1-317 3.00e-142

protein fuzzy and homologs; Protein fuzzy (or FUZ) is a planar cell polarity (PCP) effector that controls multiple cellular processes during development. PCP signalling is an evolutionarily conserved pathway by which directional information regarding polarized cell movement is provided to cells. The PCP signalling axis involves PCP core and PCP effector genes, which are activated consecutively to govern orientated cell migration and the establishment of cytoskeletal structures. Dishevelled (Dvl in mammals or Dsh in Drosophila) and Fuz (or fuzzy in Drosophila) are two representative PCP core and effector genes, respectively. PCP regulates mammalian nervous system development; Fuz-null mutant mice display neural tube defects due to failure of directional cell motility and cell fusion.


Pssm-ID: 411043 [Multi-domain]  Cd Length: 401  Bit Score: 407.12  E-value: 3.00e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265   1 MVFGAMVLLVGLEELTNIRNVERLKKDLRASYCLIDSFLGDSELIGDLTQCVDCVIPPEGSLLQEALSGFAEAAGTTFVS 80
Cdd:cd21091   86 NVFGAMVLLIGLDELTNITNVERLKKDLRACYPLIDSFLGNSELMGDLTQCVDCVIPPEGAALQECLDGFAEAAESTFGC 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265  81 LVVSGRVVAATEGWWRLGTPEAVLLPWLVGSLPPQTARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLLCGPSPPLSQLY 160
Cdd:cd21091  166 LVVGGRVVVATEKWWRLDTQELVLLPWLVNSLPPTQARDYPVYLPHGSPTVPHRLLTFQLLSGVEVCVLCGPEPSLQQVQ 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265 161 PQLLERWWQPLLDPLRACLPLGPRALPSGFPLHTDILGLLLLHLELKRCLFTVEPLGDKA----EPSPEQRRRLLRNFYT 236
Cdd:cd21091  246 RELVERFWRPLLDPLRACLRLVPRALPLGVPLDSGVLGLLLINRETRRSLFTVQPSEDSArkrmSLSDEQRRDALRSFYT 325

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265 237 LVTSTHFPPEPGPPEKTEDEVY-QAQLPRACYLVLGTeepgtgVRLVALQLGLRRLLLLLSPQSPTHGLRSLATHTLHAL 315
Cdd:cd21091  326 LVADRYFPPETGPDENTTTTVHpFSHLPRECYVVTKS------HKCYAIQTSQYQLFLLFSPAVPTHALRSLATRTLQAL 399


                 ..
gi 768011265 316 TP 317
Cdd:cd21091  400 TK 401
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 74-169 1.02e-15

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 71.49  E-value: 1.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768011265   74 AGTTFVSLVVSGRVVAATEGWW-RLGTPEAVLLPWLVGSLPPQT--ARDYPVYLPHGSPTVPHRLLTLTLLPSLELCLLC 150
Cdd:pfam19037   1 KSLLFALLLVGGKLVAAYRPRWaSLHPSDLLLLFLLVQSSSPFKslELWIPICLPKFNPGVLHRYISFLGDINLCLLLLS 80

                          90
                  ....*....|....*....
gi 768011265  151 GPSPPLsQLYPQLLERWWQ 169
Cdd:pfam19037  81 GDKPAF-FELSLLDDRFWL 98
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 1-38 2.12e-06

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 46.05  E-value: 2.12e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 768011265    1 MVFGAMVLLVGLEELTNIRN---VERLKKDLRASYCLIDSF 38
Cdd:pfam19036  85 VVYNQILSLLGLPQLTRIFNrrpNEDLRRLLSGLEDLLDSL 125
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 207-273 4.42e-04

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 39.16  E-value: 4.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768011265  207 KRCLFTVEPLGdkAEPSPEQRRRLLRNFYTLVTSTHFPPepgppektedevyqAQLPRACYLVLGTE 273
Cdd:pfam19038  13 VQFTAPSLPTD--PPYTTEQRRRRLRSFYQLLHSTLHSP--------------SGPLKLLYKVSDYE 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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