NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|768006778|ref|XP_011524810|]
View 

zinc finger protein 420 isoform X3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-506 2.58e-18

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.21  E-value: 2.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778  94 KPYECKQCGKAFSRDSQLSLHQRLHTGEKPYAC--KECGKAFTQSSQLILHHRIHTGEKPYKCEecgKAFIRSSQLTRHQ 171
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 172 KV----HTGEKPYECKECGKAFTQNSQLTLHQRLHTgekLYECKECRKVFTQLSQLILHKRIHtGEKPYECKeCGKAFIC 247
Cdd:COG5048  109 SLssssSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS---NLRNNPLPGNNSSSVNTPQSNSLH-PPLPANSL-SKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 248 GSQLSQHQKIHNGEKPYECKECGRAFIRGSLLmQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGK 327
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSS-SDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 328 MFSHGSQLTQHQRIHTGE-------KPYQCKECGKAFNRGSLLTRHQR--IHTGE--KPYECKE--CGKTFSRGSELTQH 394
Cdd:COG5048  263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 395 ERIHTGEKPYECKEC-------GKSFIRGSQLTQHQRIHTGEKPYEC--KECRMAFTQSSHLSQHQRLHTGEKPYVCN-- 463
Cdd:COG5048  343 ILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 768006778 464 ECGKAFARGLLLIQHQRIHTGEKPYQCkeCGKAFIRGSQLTQH 506
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 1.50e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.50e-04
                          10        20
                  ....*....|....*....|....*.
gi 768006778  558 HLSRHQRIHTGEKPYQCKECGKAFTR 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
503-527 7.87e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.87e-04
                          10        20
                  ....*....|....*....|....*
gi 768006778  503 LTQHQRIHTGEKPYECKECGKAFSH 527
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-555 5.72e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.72e-03
                          10        20
                  ....*....|....*....|....*
gi 768006778  531 LTLHQRIHTGEKPYECRECRKAFTQ 555
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-506 2.58e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.21  E-value: 2.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778  94 KPYECKQCGKAFSRDSQLSLHQRLHTGEKPYAC--KECGKAFTQSSQLILHHRIHTGEKPYKCEecgKAFIRSSQLTRHQ 171
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 172 KV----HTGEKPYECKECGKAFTQNSQLTLHQRLHTgekLYECKECRKVFTQLSQLILHKRIHtGEKPYECKeCGKAFIC 247
Cdd:COG5048  109 SLssssSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS---NLRNNPLPGNNSSSVNTPQSNSLH-PPLPANSL-SKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 248 GSQLSQHQKIHNGEKPYECKECGRAFIRGSLLmQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGK 327
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSS-SDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 328 MFSHGSQLTQHQRIHTGE-------KPYQCKECGKAFNRGSLLTRHQR--IHTGE--KPYECKE--CGKTFSRGSELTQH 394
Cdd:COG5048  263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 395 ERIHTGEKPYECKEC-------GKSFIRGSQLTQHQRIHTGEKPYEC--KECRMAFTQSSHLSQHQRLHTGEKPYVCN-- 463
Cdd:COG5048  343 ILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 768006778 464 ECGKAFARGLLLIQHQRIHTGEKPYQCkeCGKAFIRGSQLTQH 506
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 1.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.50e-04
                          10        20
                  ....*....|....*....|....*.
gi 768006778  558 HLSRHQRIHTGEKPYQCKECGKAFTR 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-303 3.59e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.59e-04
                          10        20
                  ....*....|....*....|....*
gi 768006778  279 LMQHQRIHTGEKPYKCEECGKAFIR 303
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
503-527 7.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.87e-04
                          10        20
                  ....*....|....*....|....*
gi 768006778  503 LTQHQRIHTGEKPYECKECGKAFSH 527
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-555 5.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.72e-03
                          10        20
                  ....*....|....*....|....*
gi 768006778  531 LTLHQRIHTGEKPYECRECRKAFTQ 555
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
94-506 2.58e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 88.21  E-value: 2.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778  94 KPYECKQCGKAFSRDSQLSLHQRLHTGEKPYAC--KECGKAFTQSSQLILHHRIHTGEKPYKCEecgKAFIRSSQLTRHQ 171
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 172 KV----HTGEKPYECKECGKAFTQNSQLTLHQRLHTgekLYECKECRKVFTQLSQLILHKRIHtGEKPYECKeCGKAFIC 247
Cdd:COG5048  109 SLssssSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS---NLRNNPLPGNNSSSVNTPQSNSLH-PPLPANSL-SKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 248 GSQLSQHQKIHNGEKPYECKECGRAFIRGSLLmQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGK 327
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSS-SDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 328 MFSHGSQLTQHQRIHTGE-------KPYQCKECGKAFNRGSLLTRHQR--IHTGE--KPYECKE--CGKTFSRGSELTQH 394
Cdd:COG5048  263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 395 ERIHTGEKPYECKEC-------GKSFIRGSQLTQHQRIHTGEKPYEC--KECRMAFTQSSHLSQHQRLHTGEKPYVCN-- 463
Cdd:COG5048  343 ILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 768006778 464 ECGKAFARGLLLIQHQRIHTGEKPYQCkeCGKAFIRGSQLTQH 506
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
178-590 1.37e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 1.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 178 KPYECKECGKAFTQNSQLTLHQRLHTGEKLYEC--KECRKVFTQLSQLILHKRIHTGEKpyeckecgkaficgSQLSQHQ 255
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNP--------------SDLNSKS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 256 KIHNGEKPYECKE--CGRAFIRGSLLMQHQRIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEK-------PYECKECG 326
Cdd:COG5048   98 LPLSNSKASSSSLssSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 327 KMFSHGSQLTQHQRIHTGEKPYQCKECGKAFNRGSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTGEKPYEC 406
Cdd:COG5048  178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 407 KECGKSF--IRGSQLTQHQRIHTGE-----KPYECKECRMAFTQSSHLSQHQR--LHTGE--KPYVCNE--CGKAFARGL 473
Cdd:COG5048  258 SESPRSSlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 474 LLIQHQRIHTGEKPYQCKEC-------GKAFIRGSQLTQHQRIHTGEKPYEC--KECGKAFSHGSQLTLHQRIHTGEKPY 544
Cdd:COG5048  338 ALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPY 417

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 768006778 545 ECR--ECRKAFTQSSHLSRHQRIHTGEKPYQCkeCGKAFTRGSQLTQH 590
Cdd:COG5048  418 NCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-602 4.93e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 4.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 206 KLYECKECRKVFTQLSQLILHKRIHTGEKPYEC--KECGKAFICGSQLSQHQKIHNGEKPYEC--KECGRAFIRGSLLMQ 281
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 282 HQrIHTGEKPYKCEECGKAFIRGSQLTQHQRIHTNEKPYECKECGKMFSHGSQ--LTQHQRIHTgekpyqcKECGKAFNR 359
Cdd:COG5048  112 SS-SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnSLHPPLPAN-------SLSKDPSSN 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 360 GSLLTRHQRIHTGEKPYECKECGKTFSRGSELTQHERIHTgEKPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRM 439
Cdd:COG5048  184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 440 AFTQSSHLSQHQRLHTGE-------KPYVCNECGKAFARGLLLIQHQR--IHTGE--KPYQCKE--CGKAFIRGSQLTQH 506
Cdd:COG5048  263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 507 QRIHTGEKPYECK--ECGKAFSHGS-----QLTLHQRIHTGEKPYEC--RECRKAFTQSSHLSRHQRIHTGEKPYQCK-- 575
Cdd:COG5048  343 ILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                        410       420
                 ....*....|....*....|....*..
gi 768006778 576 ECGKAFTRGSQLTQHQRIHISEKSFEY 602
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-603 4.61e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 4.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 249 SQLSQHQKIHNGEKPYECKECGRAFIRGSLLMQHQRIHTGEKPYKC--EECGKAFIRGSQLTQHQRIHTNEKPYECkecg 326
Cdd:COG5048   19 TPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN---- 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 327 kmfSHGSQLTQHQRIHTGE--------KPYQCKECGKAFNRGSLLTRHQRIHTgeKPYECKECGKTFSRGSELTQHERIH 398
Cdd:COG5048   95 ---SKSLPLSNSKASSSSLsssssnsnDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHP 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 399 TGEKPYECKECGKSFIRGSqltqHQRIHTGEKPYECKECRMAFTQSSHLSQHQRLHTGEKPYVCNECGKAFARGLLLIQH 478
Cdd:COG5048  170 PLPANSLSKDPSSNLSLLI----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 479 QRIHTGEKPYQCKECGKAF--IRGSQLTQHQRIHTGekpyeckecgkafSHGSQLTLHQrihtgekpyeCRECRKAFTQS 556
Cdd:COG5048  246 SSLSSSDSSSSASESPRSSlpTASSQSSSPNESDSS-------------SEKGFSLPIK----------SKQCNISFSRS 302

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768006778 557 SHLSRHQR--IHTGE--KPYQCKE--CGKAFTRGSQLTQHQRIHISEKSFEYK 603
Cdd:COG5048  303 SPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
58-366 6.54e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 6.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778  58 HSRCHSTEKPYKCKECGKAFRRASHLTQHQSIHTGEKPYECKQCGKAFSRDSQLSLHQRLHTGEKPYACKECGKAFTQSS 137
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 138 QLILHHRIHTGE-------KPYKCEECGKAFIRSSQLTRHQ--KVHTGE--KPYECKE--CGKAFTQNSQLTLHQRLHTG 204
Cdd:COG5048  269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 205 EKLYECK--ECRKVFTQLSqlilhkrihtgekpyeckecgkaFICGSQLSQHQKIHNGEKPYEC--KECGRAFIRGSLLM 280
Cdd:COG5048  349 ISPAKEKllNSSSKFSPLL-----------------------NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLS 405

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778 281 QHQRIHTGEKPYKCEecgkafirgsqltqhqrihtnekpyeCKECGKMFSHGSQLTQHQRIHTGEKPYQCkECGKAFNRG 360
Cdd:COG5048  406 LHIITHLSFRPYNCK--------------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRD 458


                 ....*.
gi 768006778 361 SLLTRH 366
Cdd:COG5048  459 LDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 1.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.50e-04
                          10        20
                  ....*....|....*....|....*.
gi 768006778  558 HLSRHQRIHTGEKPYQCKECGKAFTR 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-303 3.59e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.59e-04
                          10        20
                  ....*....|....*....|....*
gi 768006778  279 LMQHQRIHTGEKPYKCEECGKAFIR 303
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
46-182 4.41e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 4.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778  46 MSIFNQHTYLSQHSRC--HSTE--KPYKCKE--CGKAFRRASHLTQHQSIHTGEKPYECK--QCGKAFS-----RDSQLS 112
Cdd:COG5048  296 NISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpllnnEPPQSL 375

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768006778 113 LHQRLHTGEKPYAC--KECGKAFTQSSQLILHHRIHTGEKP--YKCEECGKAFIRSSQLTRHQKVHTGEKPYEC 182
Cdd:COG5048  376 QQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-387 5.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.42e-04
                          10        20
                  ....*....|....*....|....*
gi 768006778  363 LTRHQRIHTGEKPYECKECGKTFSR 387
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
390-415 7.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 768006778  390 ELTQHERIHTGEKPYECKECGKSFIR 415
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-359 7.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.35e-04
                          10        20
                  ....*....|....*....|....*
gi 768006778  335 LTQHQRIHTGEKPYQCKECGKAFNR 359
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
503-527 7.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.87e-04
                          10        20
                  ....*....|....*....|....*
gi 768006778  503 LTQHQRIHTGEKPYECKECGKAFSH 527
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 87-198 1.01e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768006778  87 QSIHTGEKPYECKQCGKAFSRDSQLSLH---QRLHT-GEKPYACK--ECGKAFTQSSQLiLHHRIHTGEKPYKCEECGKa 160
Cdd:COG5189  309 EMIDVRKLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP- 386

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 768006778 161 firssqlTRHQKVHTGEKPYECKECGKAFTQNSQLTLH 198
Cdd:COG5189  387 -------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
167-191 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*
gi 768006778  167 LTRHQKVHTGEKPYECKECGKAFTQ 191
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
475-499 1.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.58e-03
                          10        20
                  ....*....|....*....|....*
gi 768006778  475 LIQHQRIHTGEKPYQCKECGKAFIR 499
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-471 2.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 768006778  446 HLSQHQRLHTGEKPYVCNECGKAFAR 471
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
307-331 2.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.44e-03
                          10        20
                  ....*....|....*....|....*
gi 768006778  307 LTQHQRIHTNEKPYECKECGKMFSH 331
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
419-443 3.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.57e-03
                          10        20
                  ....*....|....*....|....*
gi 768006778  419 LTQHQRIHTGEKPYECKECRMAFTQ 443
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-247 3.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.64e-03
                          10        20
                  ....*....|....*....|....*
gi 768006778  223 LILHKRIHTGEKPYECKECGKAFIC 247
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
82-107 4.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 768006778   82 HLTQHQSIHTGEKPYECKQCGKAFSR 107
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-555 5.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.72e-03
                          10        20
                  ....*....|....*....|....*
gi 768006778  531 LTLHQRIHTGEKPYECRECRKAFTQ 555
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 152-174 7.50e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.50e-03
                          10        20
                  ....*....|....*....|...
gi 768006778  152 YKCEECGKAFIRSSQLTRHQKVH 174
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
111-135 8.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.48e-03
                          10        20
                  ....*....|....*....|....*
gi 768006778  111 LSLHQRLHTGEKPYACKECGKAFTQ 135
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
139-163 9.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.00e-03
                          10        20
                  ....*....|....*....|....*
gi 768006778  139 LILHHRIHTGEKPYKCEECGKAFIR 163
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH