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Conserved domains on  [gi|767999369|ref|XP_011524522|]
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katanin p60 ATPase-containing subunit A-like 2 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 282-429 1.40e-73

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd19509:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 163  Bit Score: 230.32  E-value: 1.40e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 282 IIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLV 361
Cdd:cd19509    1 IAGLDDAKEALKEAVILPSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767999369 362 RVLFELARYHAPSTIFLDELESVMSQRGTasgGEHEGSLRMKTELLVQMDGL-ARSEDLVFVLAASNLP 429
Cdd:cd19509   81 RALFALARELQPSIIFIDEIDSLLSERGS---GEHEASRRVKTEFLVQMDGVlNKPEDRVLVLGATNRP 146
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 51-81 3.39e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


:

Pssm-ID: 128913  Cd Length: 34  Bit Score: 37.80  E-value: 3.39e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767999369    51 RRKNLLILISHYLTQEGYIDTANALEQETKL 81
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
 
Name Accession Description Interval E-value
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 282-429 1.40e-73

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 230.32  E-value: 1.40e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 282 IIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLV 361
Cdd:cd19509    1 IAGLDDAKEALKEAVILPSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767999369 362 RVLFELARYHAPSTIFLDELESVMSQRGTasgGEHEGSLRMKTELLVQMDGL-ARSEDLVFVLAASNLP 429
Cdd:cd19509   81 RALFALARELQPSIIFIDEIDSLLSERGS---GEHEASRRVKTEFLVQMDGVlNKPEDRVLVLGATNRP 146
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 212-441 8.13e-55

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 186.75  E-value: 8.13e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 212 IIDFQGLLTDAIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQL 291
Cdd:COG1222   10 NIKALLALIDALQERLGVELALLLQPVKALELLEEAPALLLNDANLTQKRLGTPRGTAVPAESPDVTFDDIGGLDEQIEE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 292 VKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARY 370
Cdd:COG1222   90 IREAVELPLKNPELFRKYgIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELARE 169

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767999369 371 HAPSTIFLDELESVMSQRGtaSGGEHEGSLRMKTELLVQMDGLARSEDlVFVLAASNLPCL--KAIaLQPG--DR 441
Cdd:COG1222  170 KAPSIIFIDEIDAIAARRT--DDGTSGEVQRTVNQLLAELDGFESRGD-VLIIAATNRPDLldPAL-LRPGrfDR 240
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 268-446 2.15e-43

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 163.92  E-value: 2.15e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369  268 RDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISA 346
Cdd:TIGR01243 441 REVLVEVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMgIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRG 520

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369  347 STIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGgeHEGSLRMKTELLVQMDGLARSEDLVfVLAAS 426
Cdd:TIGR01243 521 PEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFD--TSVTDRIVNQLLTEMDGIQELSNVV-VIAAT 597

                         170       180
                  ....*....|....*....|.
gi 767999369  427 NLP-CLKAIALQPGDRARLRL 446
Cdd:TIGR01243 598 NRPdILDPALLRPGRFDRLIL 618
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 275-441 7.66e-42

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 153.83  E-value: 7.66e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 275 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFT--GIlSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSK 352
Cdd:PRK03992 126 PNVTYEDIGGLEEQIREVREAVELPLKKPELFEevGI-EPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQK 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 353 WRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQR---GTasGGEHEGSlRMKTELLVQMDGLARSEDlVFVLAASNLP 429
Cdd:PRK03992 205 FIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdsGT--SGDREVQ-RTLMQLLAEMDGFDPRGN-VKIIAATNRI 280

                        170
                 ....*....|....*.
gi 767999369 430 CL--KAIaLQPG--DR 441
Cdd:PRK03992 281 DIldPAI-LRPGrfDR 295
cell_div_CdvC NF041006
cell division protein CdvC;
275-429 2.07e-41

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 152.20  E-value: 2.07e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 275 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFtgilsP--W-KGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVS 351
Cdd:NF041006  98 PKVTFSDIVGLEDVKEALKEAIVYPSKRPDLF-----PlgWpRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMS 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 352 KWRGDSEKLVRVLFELARYHA-----PSTIFLDELESVMSQRGTASGGEhegsLRMKTELLVQMDGLA-RSEDL-VFVLA 424
Cdd:NF041006 173 KWLGEAEKNVAKIFKKAREKSkeegkPAIIFIDEIDALLGVYSSEVGGE----VRVRNQFLKEMDGLQdKSENYhVYVIG 248


                 ....*
gi 767999369 425 ASNLP 429
Cdd:NF041006 249 ATNKP 253
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 316-429 5.01e-40

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 141.19  E-value: 5.01e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369  316 LLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGE 395
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767999369  396 HEgslRMKTELLVQMDGLARSEDLVFVLAASNLP 429
Cdd:pfam00004  81 SR---RVVNQLLTELDGFTSSNSKVIVIAATNRP 111
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 312-448 4.26e-13

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 66.63  E-value: 4.26e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369   312 PWKGLLLYGPPGTGKTLLAKAVATECKTT---FFNISASTI--------------VSKWRGDSEKLVRVLFELARYHAPS 374
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767999369   375 TIFLDELESVMSQRGTAsggehegsLRMKTELLVQMDGLARSEDLVFVLAASNLPCLKAIALQPGDRARLRLKK 448
Cdd:smart00382  81 VLILDEITSLLDAEQEA--------LLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLL 146
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 316-381 3.13e-04

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 42.46  E-value: 3.13e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767999369 316 LLLYGPPGTGKTLLAKAVATEC-----KTTFFniSASTIVSKWRG--DSEKLVRVLFELARYHApstIFLDEL 381
Cdd:NF038214  93 VLLLGPPGTGKTHLAIALGYAAcrqgyRVRFT--TAADLVEQLAQarADGRLGRLLRRLARYDL---LIIDEL 160
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 51-81 3.39e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 37.80  E-value: 3.39e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767999369    51 RRKNLLILISHYLTQEGYIDTANALEQETKL 81
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 54-78 3.98e-03

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 34.60  E-value: 3.98e-03
                          10        20
                  ....*....|....*....|....*
gi 767999369   54 NLLILISHYLTQEGYIDTANALEQE 78
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
 
Name Accession Description Interval E-value
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 282-429 1.40e-73

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 230.32  E-value: 1.40e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 282 IIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLV 361
Cdd:cd19509    1 IAGLDDAKEALKEAVILPSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767999369 362 RVLFELARYHAPSTIFLDELESVMSQRGTasgGEHEGSLRMKTELLVQMDGL-ARSEDLVFVLAASNLP 429
Cdd:cd19509   81 RALFALARELQPSIIFIDEIDSLLSERGS---GEHEASRRVKTEFLVQMDGVlNKPEDRVLVLGATNRP 146
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 281-449 1.43e-71

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 225.25  E-value: 1.43e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 281 DIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKL 360
Cdd:cd19522    1 DIADLEEAKKLLEEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 361 VRVLFELARYHAPSTIFLDELESVMSQRGTasGGEHEGSLRMKTELLVQMDGLARSED------LVFVLAASNLPCLKAI 434
Cdd:cd19522   81 VRLLFEMARFYAPTTIFIDEIDSICSRRGT--SEEHEASRRVKSELLVQMDGVGGASEnddpskMVMVLAATNFPWDIDE 158

                        170
                 ....*....|....*
gi 767999369 435 ALqpgdraRLRLKKK 449
Cdd:cd19522  159 AL------RRRLEKR 167
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 275-429 1.90e-70

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 222.43  E-value: 1.90e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 275 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWR 354
Cdd:cd19521    2 PNVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767999369 355 GDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTasgGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLP 429
Cdd:cd19521   82 GESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGE---GESEASRRIKTELLVQMNGVGNDSQGVLVLGATNIP 153
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 261-449 5.13e-63

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 203.68  E-value: 5.13e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 261 ELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTT 340
Cdd:cd19525    3 KMIELIMSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGAT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 341 FFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTasgGEHEGSLRMKTELLVQMDGL-ARSEDL 419
Cdd:cd19525   83 FFSISASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGE---GEHESSRRIKTEFLVQLDGAtTSSEDR 159

                        170       180       190
                 ....*....|....*....|....*....|.
gi 767999369 420 VFVLAASNLPclkaialQPGDR-ARLRLKKK 449
Cdd:cd19525  160 ILVVGATNRP-------QEIDEaARRRLVKR 183
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 281-445 1.07e-56

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 186.21  E-value: 1.07e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 281 DIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKL 360
Cdd:cd19524    1 DIAGQDLAKQALQEMVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 361 VRVLFELARYHAPSTIFLDELESVMSQRgtaSGGEHEGSLRMKTELLVQMDGL-ARSEDLVFVLAASNLPclkaialQPG 439
Cdd:cd19524   81 VRALFAVARELQPSIIFIDEVDSLLSER---SEGEHEASRRLKTEFLIEFDGVqSNGDDRVLVMGATNRP-------QEL 150


                 ....*.
gi 767999369 440 DRARLR 445
Cdd:cd19524  151 DDAVLR 156
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 212-441 8.13e-55

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 186.75  E-value: 8.13e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 212 IIDFQGLLTDAIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQL 291
Cdd:COG1222   10 NIKALLALIDALQERLGVELALLLQPVKALELLEEAPALLLNDANLTQKRLGTPRGTAVPAESPDVTFDDIGGLDEQIEE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 292 VKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARY 370
Cdd:COG1222   90 IREAVELPLKNPELFRKYgIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELARE 169

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767999369 371 HAPSTIFLDELESVMSQRGtaSGGEHEGSLRMKTELLVQMDGLARSEDlVFVLAASNLPCL--KAIaLQPG--DR 441
Cdd:COG1222  170 KAPSIIFIDEIDAIAARRT--DDGTSGEVQRTVNQLLAELDGFESRGD-VLIIAATNRPDLldPAL-LRPGrfDR 240
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 281-429 1.05e-47

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 162.59  E-value: 1.05e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 281 DIIGLDAAKQLVKEAVVYPIRYPQLF--TGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSE 358
Cdd:cd19520    1 DIGGLDEVITELKELVILPLQRPELFdnSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767999369 359 KLVRVLFELARYHAPSTIFLDELESVMSQRgtaSGGEHEGSLRMKTELLVQMDGLARS-EDLVFVLAASNLP 429
Cdd:cd19520   81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQR---SSTDHEATAMMKAEFMSLWDGLSTDgNCRVIVMGATNRP 149
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 281-429 1.03e-45

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 157.45  E-value: 1.03e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 281 DIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEK 359
Cdd:cd19503    1 DIGGLDEQIASLKELIELPLKYPELFRALgLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 360 LVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEgslRMKTELLVQMDGLArSEDLVFVLAASNLP 429
Cdd:cd19503   81 NLREIFEEARSHAPSIIFIDEIDALAPKREEDQREVER---RVVAQLLTLMDGMS-SRGKVVVIAATNRP 146
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 288-439 9.13e-45

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 154.75  E-value: 9.13e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 288 AKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFE 366
Cdd:cd19511    1 VKRELKEAVEWPLKHPDAFKRLgIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767999369 367 LARYHAPSTIFLDELESVMSQRGTASGGehEGSLRMKTELLVQMDGLARSEDlVFVLAASNLPCL--KAIaLQPG 439
Cdd:cd19511   81 KARQAAPCIIFFDEIDSLAPRRGQSDSS--GVTDRVVSQLLTELDGIESLKG-VVVIAATNRPDMidPAL-LRPG 151
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 289-439 1.89e-43

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 151.12  E-value: 1.89e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 289 KQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFEL 367
Cdd:cd19528    2 KRELQELVQYPVEHPDKFLKFgMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDK 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767999369 368 ARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDlVFVLAASNLP-CLKAIALQPG 439
Cdd:cd19528   82 ARAAAPCVLFFDELDSIAKARGGNIGDAGGAADRVINQILTEMDGMNTKKN-VFIIGATNRPdIIDPAILRPG 153
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 268-446 2.15e-43

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 163.92  E-value: 2.15e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369  268 RDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISA 346
Cdd:TIGR01243 441 REVLVEVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMgIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRG 520

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369  347 STIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGgeHEGSLRMKTELLVQMDGLARSEDLVfVLAAS 426
Cdd:TIGR01243 521 PEILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFD--TSVTDRIVNQLLTEMDGIQELSNVV-VIAAT 597

                         170       180
                  ....*....|....*....|.
gi 767999369  427 NLP-CLKAIALQPGDRARLRL 446
Cdd:TIGR01243 598 NRPdILDPALLRPGRFDRLIL 618
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 277-441 2.69e-43

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 151.23  E-value: 2.69e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 277 IKWNDIIGLDAAKQLVKEAVVYpIRYPQLFT--GILSPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWR 354
Cdd:cd19501    1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTklGAKIP-KGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 355 GDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDlVFVLAASNLP-CLKA 433
Cdd:cd19501   79 GVGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAGLGGGHDEREQTLNQLLVEMDGFESNTG-VIVIAATNRPdVLDP 157

                        170
                 ....*....|
gi 767999369 434 IALQPG--DR 441
Cdd:cd19501  158 ALLRPGrfDR 167
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 279-441 2.98e-43

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 150.95  E-value: 2.98e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 279 WNDIIGLDAAKQLVKEAVVYPIRYPQLFT--GILSPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGD 356
Cdd:cd19502    2 YEDIGGLDEQIREIREVVELPLKHPELFEelGIEPP-KGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 357 SEKLVRVLFELARYHAPSTIFLDELESVMSQR-GTASGGEHEGSlRMKTELLVQMDGLARSEDlVFVLAASNLP-CLKAI 434
Cdd:cd19502   81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRfDSGTGGDREVQ-RTMLELLNQLDGFDPRGN-IKVIMATNRPdILDPA 158


                 ....*....
gi 767999369 435 ALQPG--DR 441
Cdd:cd19502  159 LLRPGrfDR 167
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 275-441 7.66e-42

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 153.83  E-value: 7.66e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 275 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFT--GIlSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSK 352
Cdd:PRK03992 126 PNVTYEDIGGLEEQIREVREAVELPLKKPELFEevGI-EPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQK 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 353 WRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQR---GTasGGEHEGSlRMKTELLVQMDGLARSEDlVFVLAASNLP 429
Cdd:PRK03992 205 FIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdsGT--SGDREVQ-RTLMQLLAEMDGFDPRGN-VKIIAATNRI 280

                        170
                 ....*....|....*.
gi 767999369 430 CL--KAIaLQPG--DR 441
Cdd:PRK03992 281 DIldPAI-LRPGrfDR 295
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 288-444 1.68e-41

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 146.10  E-value: 1.68e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 288 AKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFE 366
Cdd:cd19529    1 VKQELKEAVEWPLLKPEVFKRLgIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFR 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767999369 367 LARYHAPSTIFLDELESVMSQRGTasGGEHEGSLRMKTELLVQMDGLARSEDLVfVLAASNLP-CLKAIALQPGDRARL 444
Cdd:cd19529   81 KARQVAPCVIFFDEIDSIAPRRGT--TGDSGVTERVVNQLLTELDGLEEMNGVV-VIAATNRPdIIDPALLRAGRFDRL 156
cell_div_CdvC NF041006
cell division protein CdvC;
275-429 2.07e-41

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 152.20  E-value: 2.07e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 275 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFtgilsP--W-KGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVS 351
Cdd:NF041006  98 PKVTFSDIVGLEDVKEALKEAIVYPSKRPDLF-----PlgWpRGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMS 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 352 KWRGDSEKLVRVLFELARYHA-----PSTIFLDELESVMSQRGTASGGEhegsLRMKTELLVQMDGLA-RSEDL-VFVLA 424
Cdd:NF041006 173 KWLGEAEKNVAKIFKKAREKSkeegkPAIIFIDEIDALLGVYSSEVGGE----VRVRNQFLKEMDGLQdKSENYhVYVIG 248


                 ....*
gi 767999369 425 ASNLP 429
Cdd:NF041006 249 ATNKP 253
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 316-429 5.01e-40

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 141.19  E-value: 5.01e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369  316 LLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGE 395
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767999369  396 HEgslRMKTELLVQMDGLARSEDLVFVLAASNLP 429
Cdd:pfam00004  81 SR---RVVNQLLTELDGFTSSNSKVIVIAATNRP 111
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 288-429 1.07e-39

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 141.27  E-value: 1.07e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 288 AKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFEL 367
Cdd:cd19481    1 LKASLREAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFER 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767999369 368 ARYHAPSTIFLDELESVMSQRGtaSGGEHEGSLRMKTELLVQMDGLARSEDlVFVLAASNLP 429
Cdd:cd19481   81 ARRLAPCILFIDEIDAIGRKRD--SSGESGELRRVLNQLLTELDGVNSRSK-VLVIAATNRP 139
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 279-429 3.97e-39

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 146.59  E-value: 3.97e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 279 WNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDS 357
Cdd:COG0464  156 LDDLGGLEEVKEELRELVALPLKRPELREEYgLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGET 235

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767999369 358 EKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEgslRMKTELLVQMDGLarsEDLVFVLAASNLP 429
Cdd:COG0464  236 EKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGR---RVVNTLLTEMEEL---RSDVVVIAATNRP 301
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 281-429 2.56e-37

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 134.87  E-value: 2.56e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 281 DIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEK 359
Cdd:cd19519    1 DIGGCRKQLAQIREMVELPLRHPELFKAIgIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 360 LVRVLFELARYHAPSTIFLDELESVMSQRGTASGgehEGSLRMKTELLVQMDGLARSEDlVFVLAASNLP 429
Cdd:cd19519   81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHG---EVERRIVSQLLTLMDGLKQRAH-VIVMAATNRP 146
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 275-441 8.91e-37

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 141.06  E-value: 8.91e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 275 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKW 353
Cdd:PTZ00361 178 PLESYADIGGLEQQIQEIKEAVELPLTHPELYDDIgIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKY 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 354 RGDSEKLVRVLFELARYHAPSTIFLDELESVMSQR-GTASGGEHEGSlRMKTELLVQMDGLARSEDLVFVLAASNLPCLK 432
Cdd:PTZ00361 258 LGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRyDATSGGEKEIQ-RTMLELLNQLDGFDSRGDVKVIMATNRIESLD 336

                        170
                 ....*....|.
gi 767999369 433 AIALQPG--DR 441
Cdd:PTZ00361 337 PALIRPGriDR 347
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 285-439 1.09e-36

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 133.00  E-value: 1.09e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 285 LDAAKQLVKEAVVYPIRYPQLFT--GILSPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVR 362
Cdd:cd19530    1 LDHVREELTMSILRPIKRPDIYKalGIDLP-TGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVR 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767999369 363 VLFELARYHAPSTIFLDELESVMSQRGtasGGEHEGSLRMKTELLVQMDGL-ARSEdlVFVLAASNLP-CLKAIALQPG 439
Cdd:cd19530   80 QVFQRARASAPCVIFFDEVDALVPKRG---DGGSWASERVVNQLLTEMDGLeERSN--VFVIAATNRPdIIDPAMLRPG 153
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 275-449 2.06e-36

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 139.13  E-value: 2.06e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 275 PNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKW 353
Cdd:PTZ00454 140 PDVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIgIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKY 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 354 RGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPCLKA 433
Cdd:PTZ00454 220 LGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDAQTGADREVQRILLELLNQMDGFDQTTNVKVIMATNRADTLDP 299

                        170
                 ....*....|....*.
gi 767999369 434 IALQPGdrarlRLKKK 449
Cdd:PTZ00454 300 ALLRPG-----RLDRK 310
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 289-439 2.27e-35

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 129.56  E-value: 2.27e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 289 KQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELA 368
Cdd:cd19527    2 KKEILDTIQLPLEHPELFSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKA 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767999369 369 RYHAPSTIFLDELESVMSQRGTA--SGGEHEgslRMKTELLVQMDGLARSEDLVFVLAASNLPCLKAIAL-QPG 439
Cdd:cd19527   82 RDAKPCVIFFDELDSLAPSRGNSgdSGGVMD---RVVSQLLAELDGMSSSGQDVFVIGATNRPDLLDPALlRPG 152
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 281-429 2.94e-35

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 129.23  E-value: 2.94e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 281 DIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKL 360
Cdd:cd19523    1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 361 VRVLFELARYHAPSTIFLDELESVMSQRGTasggEHEGSLRMKTELLVQMDG-LARSEDLVFVLAASNLP 429
Cdd:cd19523   81 LQASFLAARCRQPSVLFISDLDALLSSQDD----EASPVGRLQVELLAQLDGvLGSGEDGVLVVCTTSKP 146
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 256-448 1.07e-34

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 138.50  E-value: 1.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369  256 NSEMRELAAVVSRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVA 334
Cdd:TIGR01243 154 ATEVEIREKPVREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLgIEPPKGVLLYGPPGTGKTLLAKAVA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369  335 TECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGgehEGSLRMKTELLVQMDGLa 414
Cdd:TIGR01243 234 NEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTG---EVEKRVVAQLLTLMDGL- 309

                         170       180       190
                  ....*....|....*....|....*....|....
gi 767999369  415 RSEDLVFVLAASNLPclkaIALQPGDRARLRLKK 448
Cdd:TIGR01243 310 KGRGRVIVIGATNRP----DALDPALRRPGRFDR 339
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 288-439 9.82e-33

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 122.15  E-value: 9.82e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 288 AKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFE 366
Cdd:cd19526    1 VKKALEETIEWPSKYPKIFASSpLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767999369 367 LARYHAPSTIFLDELESVMSQRGTASGGEHEgslRMKTELLVQMDGlARSEDLVFVLAASNLPCLKAIA-LQPG 439
Cdd:cd19526   81 RAQSAKPCILFFDEFDSIAPKRGHDSTGVTD---RVVNQLLTQLDG-VEGLDGVYVLAATSRPDLIDPAlLRPG 150
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 281-429 1.24e-31

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 119.82  E-value: 1.24e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 281 DIIGLDAAKQLVKEAVVYPIRYPQLF--TGILSPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSE 358
Cdd:cd19518    1 DIGGMDSTLKELCELLIHPILPPEYFqhLGVEPP-RGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESE 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767999369 359 KLVRVLFELARYHAPSTIFLDELESVMSQRGTASggeHEGSLRMKTELLVQMDGL---ARSEDLVFVLAASNLP 429
Cdd:cd19518   80 EKIRELFDQAISNAPCIVFIDEIDAITPKRESAQ---REMERRIVSQLLTCMDELnneKTAGGPVLVIGATNRP 150
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
281-439 7.50e-31

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 126.69  E-value: 7.50e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 281 DIIGLDAAKQLVKEAVVY---PIRYPQLFTGIlsPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDS 357
Cdd:PRK10733 153 DVAGCDEAKEEVAELVEYlrePSRFQKLGGKI--P-KGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVG 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 358 EKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVfVLAASNLP-CLKAIAL 436
Cdd:PRK10733 230 ASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGII-VIAATNRPdVLDPALL 308


                 ...
gi 767999369 437 QPG 439
Cdd:PRK10733 309 RPG 311
ftsH CHL00176
cell division protein; Validated
 277-441 9.98e-31

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 125.93  E-value: 9.98e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 277 IKWNDIIGLDAAKQLVKEaVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRG 355
Cdd:CHL00176 180 ITFRDIAGIEEAKEEFEE-VVSFLKKPERFTAVgAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 356 DSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVfVLAASN-LPCLKAI 434
Cdd:CHL00176 259 VGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRGAGIGGGNDEREQTLNQLLTEMDGFKGNKGVI-VIAATNrVDILDAA 337


                 ....*....
gi 767999369 435 ALQPG--DR 441
Cdd:CHL00176 338 LLRPGrfDR 346
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 281-429 3.31e-30

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 115.68  E-value: 3.31e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 281 DIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATEC-----KTTFFNISASTIVSKWR 354
Cdd:cd19517    1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFkITPPRGVLFHGPPGTGKTLMARALAAECskggqKVSFFMRKGADCLSKWV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767999369 355 GDSEKLVRVLFELARYHAPSTIFLDELESVMSQRGTASGGEHEGslrMKTELLVQMDGL-ARSEdlVFVLAASNLP 429
Cdd:cd19517   81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHAS---IVSTLLALMDGLdNRGQ--VVVIGATNRP 151
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
274-429 9.01e-30

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 122.84  E-value: 9.01e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 274 NPNIKWNDIIGLDAAKQLVKEAVVYpIRYPQLFT--G--IlsPwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTI 349
Cdd:COG0465  136 KPKVTFDDVAGVDEAKEELQEIVDF-LKDPEKFTrlGakI--P-KGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDF 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 350 VskwrgdsEKLV-----RV--LFELARYHAPSTIFLDELESVMSQRGTASGG---EHEGSLrmkTELLVQMDGLARSEDL 419
Cdd:COG0465  212 V-------EMFVgvgasRVrdLFEQAKKNAPCIIFIDEIDAVGRQRGAGLGGghdEREQTL---NQLLVEMDGFEGNEGV 281

                        170
                 ....*....|
gi 767999369 420 VfVLAASNLP 429
Cdd:COG0465  282 I-VIAATNRP 290
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
279-429 3.08e-25

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 104.20  E-value: 3.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 279 WNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSE 358
Cdd:COG1223    1 LDDVVGQEEAKKKLKLIIKELRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767999369 359 KLVRVLFELARyHAPSTIFLDELESVMSQRGTASG-GEhegSLRMKTELLVQMDGLARSedlVFVLAASNLP 429
Cdd:COG1223   81 RNLRKLFDFAR-RAPCVIFFDEFDAIAKDRGDQNDvGE---VKRVVNALLQELDGLPSG---SVVIAATNHP 145
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 283-446 1.34e-20

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 88.36  E-value: 1.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 283 IGLDAAKQLVKEAVvypirypqlftgILSPWKGLLLYGPPGTGKTLLAKAVATEC---KTTFFNISASTIVSKWRGDSEK 359
Cdd:cd00009    1 VGQEEAIEALREAL------------ELPPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELF 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 360 ---LVRVLFELARYHAPSTIFLDELESVmsqrgtaSGGEHEGSLRMktelLVQMDGLARSEDLVFVLAASNLPCLKAIAL 436
Cdd:cd00009   69 ghfLVRLLFELAEKAKPGVLFIDEIDSL-------SRGAQNALLRV----LETLNDLRIDRENVRVIGATNRPLLGDLDR 137

                        170
                 ....*....|
gi 767999369 437 QPGDRARLRL 446
Cdd:cd00009  138 ALYDRLDIRI 147
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 314-439 2.80e-14

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 70.98  E-value: 2.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 314 KGLLLYGPPGTGKTLLAKAV-----ATECKTtffnISASTIVSKWRGDSEKLVRVLF-----ELARYHAPS---TIFLDE 380
Cdd:cd19504   36 KGILLYGPPGTGKTLMARQIgkmlnAREPKI----VNGPEILNKYVGESEANIRKLFadaeeEQRRLGANSglhIIIFDE 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 381 LESVMSQRGTASGGEHEGSlRMKTELLVQMDGLARSEDlVFVLAASNLPCLKAIA-LQPG 439
Cdd:cd19504  112 IDAICKQRGSMAGSTGVHD-TVVNQLLSKIDGVEQLNN-ILVIGMTNRKDLIDEAlLRPG 169
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 281-427 4.24e-14

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 70.09  E-value: 4.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 281 DIIGLDAAKQLV--------KEAVVYPIRYPqlftgilspwKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSK 352
Cdd:cd19507    1 DVGGLDNLKDWLkkrkaafsKQASAYGLPTP----------KGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGG 70

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767999369 353 WRGDSEKLVRVLFELARYHAPSTIFLDELESVMSqrGTASGGEHEGSLRMKTELLVQMdglARSEDLVFVLAASN 427
Cdd:cd19507   71 LVGESESRLRQMIQTAEAIAPCVLWIDEIEKGFS--NADSKGDSGTSSRVLGTFLTWL---QEKKKPVFVVATAN 140
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 316-446 6.67e-14

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 70.55  E-value: 6.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 316 LLLYGPPGTGKTLLAKAVA---------TECKTTFFNISASTIVSKWRGDSEKLVRVLF----ELAR-YHAPSTIFLDEL 381
Cdd:cd19508   55 VLLHGPPGTGKTSLCKALAqklsirlssRYRYGQLIEINSHSLFSKWFSESGKLVTKMFqkiqELIDdKDALVFVLIDEV 134

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767999369 382 ESVMSQRGTA-SGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNlpcLKAIALQPGDRARLRL 446
Cdd:cd19508  135 ESLAAARSASsSGTEPSDAIRVVNAVLTQIDRIKRYHNNVILLTSNL---LEKIDVAFVDRADIKQ 197
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 312-448 4.26e-13

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 66.63  E-value: 4.26e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369   312 PWKGLLLYGPPGTGKTLLAKAVATECKTT---FFNISASTI--------------VSKWRGDSEKLVRVLFELARYHAPS 374
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767999369   375 TIFLDELESVMSQRGTAsggehegsLRMKTELLVQMDGLARSEDLVFVLAASNLPCLKAIALQPGDRARLRLKK 448
Cdd:smart00382  81 VLILDEITSLLDAEQEA--------LLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLL 146
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 314-429 6.05e-10

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 57.92  E-value: 6.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 314 KGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDS--EKLVRVLFELARYHAPSTIFLDELESVMSQRGTA 391
Cdd:cd19506   27 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTFYKKVPK 106

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767999369 392 SGGEHEGSlRMKTElLVQMDGLARSEDLVFVLAASNLP 429
Cdd:cd19506  107 TEKQLDPK-RLKKD-LPKILKSLKPEDRVLIVGTTSRP 142
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 316-380 9.85e-08

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 54.29  E-value: 9.85e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767999369 316 LLLYGPPGTGKTLLAKAVATECKTTFFNISASTivskwrgDSEKLVRVLFELA---RYHAPSTI-FLDE 380
Cdd:COG2256   52 MILWGPPGTGKTTLARLIANATDAEFVALSAVT-------SGVKDIREVIEEArerRAYGRRTIlFVDE 113
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 316-380 1.31e-07

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 53.94  E-value: 1.31e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767999369 316 LLLYGPPGTGKTLLAKAVATECKTTFFNISASTivskwrgDSEKLVRVLFELARYHAPS---TI-FLDE 380
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEALSAVT-------SGVKDLREVIEEARQRRSAgrrTIlFIDE 100
ycf46 CHL00195
Ycf46; Provisional
 274-427 3.85e-07

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 52.71  E-value: 3.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 274 NPNIKWNDIIGLDAAKQ--------LVKEAVVYPIRYPqlftgilspwKGLLLYGPPGTGKTLLAKAVATECKTTFFNIS 345
Cdd:CHL00195 222 SVNEKISDIGGLDNLKDwlkkrstsFSKQASNYGLPTP----------RGLLLVGIQGTGKSLTAKAIANDWQLPLLRLD 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 346 ASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSqrGTASGGEHEGSLRMKTELLVQmdgLARSEDLVFVLAA 425
Cdd:CHL00195 292 VGKLFGGIVGESESRMRQMIRIAEALSPCILWIDEIDKAFS--NSESKGDSGTTNRVLATFITW---LSEKKSPVFVVAT 366


                 ..
gi 767999369 426 SN 427
Cdd:CHL00195 367 AN 368
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 312-439 3.44e-06

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 46.96  E-value: 3.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 312 PWK-GLLLYGPPGTGKTLLAKAVATECKTTFFNISASTivskwRGDSEKLVRVLfeLARYHAPSTIFLDELESVMSQR-- 388
Cdd:cd19510   21 PYRrGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSE-----VVLTDDRLNHL--LNTAPKQSIILLEDIDAAFESReh 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767999369 389 ----GTASGGEHEGSLrmkTELLVQMDGLARSEDLVFVLAASNLPCLKAIALQPG 439
Cdd:cd19510   94 nkknPSAYGGLSRVTF---SGLLNALDGVASSEERIVFMTTNHIERLDPALIRPG 145
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
314-364 6.61e-06

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 48.43  E-value: 6.61e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767999369 314 KGLLLYGPPGTGKTLLAKAVATEC--KTTFFNISASTIVSKWRGDSEKLVRVL 364
Cdd:COG1224   65 KGILIVGPPGTGKTALAVAIARELgeDTPFVAISGSEIYSAELKKTEFLMQAL 117
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 240-443 6.68e-05

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 45.61  E-value: 6.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369  240 DPSERLLKPLSAFIGMNSEMRELAAVVSRD------------IYLHNPNIKWNDIIGLDAAKQ---LVKEAVVYPIRYPQ 304
Cdd:TIGR03922 224 DPSYRLVTTTAETIEARTDPWDPSSAPSRAefvdpaaaerkaKLLAEAEAELAEQIGLERVKRqvaALKSSTAMALARAE 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369  305 LFTGILSPWKGLLLYGPPGTGKTLLAKAVATE-C------KTTFFNISASTIVSKWRGDSEKLVRVLFELAryhAPSTIF 377
Cdd:TIGR03922 304 RGLPVAQTSNHMLFAGPPGTGKTTIARVVAKIyCglgvlrKPLVREVSRADLIGQYIGESEAKTNEIIDSA---LGGVLF 380

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767999369  378 LDELESVMSQRGTAsgGEHEGSLRMKTeLLVQMDglARSEDLVFVLAASNLPCLKAIALQPGDRAR 443
Cdd:TIGR03922 381 LDEAYTLVETGYGQ--KDPFGLEAIDT-LLARME--NDRDRLVVIGAGYRKDLDKFLEVNEGLRSR 441
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 311-429 1.87e-04

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 41.74  E-value: 1.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 311 SPWKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRgDSEKLVRVLFELARYHAPSTI-FLDELESVMSQRG 389
Cdd:cd19512   20 GLYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAIHKVFDWANTSRRGLLlFVDEADAFLRKRS 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767999369 390 TASGGEhegSLRMKTELLVQMDGlARSEDLVFVLaASNLP 429
Cdd:cd19512   99 TEKISE---DLRAALNAFLYRTG-EQSNKFMLVL-ASNQP 133
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 314-351 2.06e-04

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 43.45  E-value: 2.06e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 767999369  314 KGLLLYGPPGTGKTLLAKAVATEC--KTTFFNISASTIVS 351
Cdd:pfam06068  51 RAVLIAGPPGTGKTALAIAISKELgeDTPFTSISGSEVYS 90
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 317-382 3.08e-04

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 41.41  E-value: 3.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767999369  317 LLYGPPGTGKTLLAKAVA-----TECKTTFFNISA---STIVSKWRGDSEKLVRV-----LFELARYHAPSTIFLDELE 382
Cdd:pfam07724   7 LFLGPTGVGKTELAKALAellfgDERALIRIDMSEymeEHSVSRLIGAPPGYVGYeeggqLTEAVRRKPYSIVLIDEIE 85
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 316-381 3.13e-04

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 42.46  E-value: 3.13e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767999369 316 LLLYGPPGTGKTLLAKAVATEC-----KTTFFniSASTIVSKWRG--DSEKLVRVLFELARYHApstIFLDEL 381
Cdd:NF038214  93 VLLLGPPGTGKTHLAIALGYAAcrqgyRVRFT--TAADLVEQLAQarADGRLGRLLRRLARYDL---LIIDEL 160
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 316-345 3.38e-04

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 41.78  E-value: 3.38e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 767999369 316 LLLYGPPGTGKTLLAKAVATECKTTFFNIS 345
Cdd:cd19500   40 LCLVGPPGVGKTSLGKSIARALGRKFVRIS 69
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 51-81 3.39e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 37.80  E-value: 3.39e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 767999369    51 RRKNLLILISHYLTQEGYIDTANALEQETKL 81
Cdd:smart00667   2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 286-335 3.45e-04

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 42.46  E-value: 3.45e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767999369 286 DAAKQLVKEAVV---YPIRypQLFTGILSpwKG-LLLYGPPGTGKTLLAKAVAT 335
Cdd:COG0714    4 ARLRAEIGKVYVgqeELIE--LVLIALLA--GGhLLLEGVPGVGKTTLAKALAR 53
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
316-340 4.02e-04

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 42.43  E-value: 4.02e-04
                         10        20
                 ....*....|....*....|....*....
gi 767999369 316 LLLYGPPGTGKTLLAKAVATE----CKTT 340
Cdd:PRK00080  54 VLLYGPPGLGKTTLANIIANEmgvnIRIT 82
PRK08116 PRK08116
hypothetical protein; Validated
 315-336 5.40e-04

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 41.93  E-value: 5.40e-04
                         10        20
                 ....*....|....*....|..
gi 767999369 315 GLLLYGPPGTGKTLLAKAVATE 336
Cdd:PRK08116 116 GLLLWGSVGTGKTYLAACIANE 137
PRK04195 PRK04195
replication factor C large subunit; Provisional
 280-336 5.60e-04

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 42.60  E-value: 5.60e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767999369 280 NDIIGLDAAKQLVKE-AVVYPIRYPQlftgilspwKGLLLYGPPGTGKTLLAKAVATE 336
Cdd:PRK04195  14 SDVVGNEKAKEQLREwIESWLKGKPK---------KALLLYGPPGVGKTSLAHALAND 62
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 310-376 7.38e-04

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 40.44  E-value: 7.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 310 LSPWKGLLLYGPPGTGKTLLAKAVATEC---------------KTTFFNISASTIVSKWRgDSEKLVRVLFELARYHAPS 374
Cdd:cd19505    9 LSPSKGILLIGSIETGRSYLIKSLAANSyvplirislnkllynKPDFGNDDWIDGMLILK-ESLHRLNLQFELAKAMSPC 87


                 ..
gi 767999369 375 TI 376
Cdd:cd19505   88 II 89
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 315-382 1.09e-03

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 39.20  E-value: 1.09e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767999369  315 GLLLYGPPGTGKTLLAK--AVATECKTTFF-----NISASTIVSKWRGDSEKLVRVLFELARyhA---PSTIFLDELE 382
Cdd:pfam07728   1 GVLLVGPPGTGKTELAErlAAALSNRPVFYvqltrDTTEEDLFGRRNIDPGGASWVDGPLVR--AareGEIAVLDEIN 76
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
314-343 1.69e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 40.15  E-value: 1.69e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 767999369 314 KGLLLYGPPGTGKTLLAKAVATEC-----KTTFFN 343
Cdd:COG1484  100 ENLILLGPPGTGKTHLAIALGHEAcragyRVRFTT 134
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 316-335 1.84e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 40.79  E-value: 1.84e-03
                         10        20
                 ....*....|....*....|
gi 767999369 316 LLLYGPPGTGKTLLAKAVAT 335
Cdd:COG0606  214 LLMIGPPGSGKTMLARRLPG 233
PRK13341 PRK13341
AAA family ATPase;
316-346 1.90e-03

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 40.81  E-value: 1.90e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 767999369 316 LLLYGPPGTGKTLLAKAVATECKTTFFNISA 346
Cdd:PRK13341  55 LILYGPPGVGKTTLARIIANHTRAHFSSLNA 85
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 316-335 2.35e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 39.44  E-value: 2.35e-03
                          10        20
                  ....*....|....*....|
gi 767999369  316 LLLYGPPGTGKTLLAKAVAT 335
Cdd:pfam01078  25 LLMIGPPGSGKTMLAKRLPG 44
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 316-340 2.83e-03

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 38.64  E-value: 2.83e-03
                          10        20
                  ....*....|....*....|....*....
gi 767999369  316 LLLYGPPGTGKTLLAKAVATE----CKTT 340
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEmgvnIRIT 64
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
316-336 3.24e-03

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 39.83  E-value: 3.24e-03
                         10        20
                 ....*....|....*....|.
gi 767999369 316 LLLYGPPGTGKTLLAKAVATE 336
Cdd:COG1474   54 VLIYGPTGTGKTAVAKYVLEE 74
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 54-78 3.98e-03

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 34.60  E-value: 3.98e-03
                          10        20
                  ....*....|....*....|....*
gi 767999369   54 NLLILISHYLTQEGYIDTANALEQE 78
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 314-334 5.11e-03

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 39.37  E-value: 5.11e-03
                         10        20
                 ....*....|....*....|.
gi 767999369 314 KGLLLYGPPGTGKTLLAKAVA 334
Cdd:COG1401  222 KNVILAGPPGTGKTYLARRLA 242
Parvo_NS1 pfam01057
Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses ...
 303-335 6.19e-03

Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.


Pssm-ID: 426020  Cd Length: 271  Bit Score: 38.44  E-value: 6.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767999369  303 PQLFTGILSPW----KG----LLLYGPPGTGKTLLAKAVAT 335
Cdd:pfam01057  95 PAEVGSVLLAWlskqFGkrntVWFYGPASTGKTNLAQAIAH 135
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
 317-395 6.73e-03

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 39.05  E-value: 6.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767999369 317 LLYGPPGTGKTLLAKAVA------------TECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESV 384
Cdd:PRK11034 211 LLVGESGVGKTAIAEGLAwrivqgdvpevmADCTIYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTI 290

                         90
                 ....*....|.
gi 767999369 385 MSQrGTASGGE 395
Cdd:PRK11034 291 IGA-GAASGGQ 300
Lon COG0466
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ...
 314-334 7.43e-03

ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440234 [Multi-domain]  Cd Length: 785  Bit Score: 39.23  E-value: 7.43e-03
                         10        20
                 ....*....|....*....|...
gi 767999369 314 KG--LLLYGPPGTGKTLLAKAVA 334
Cdd:COG0466  351 KGpiLCLVGPPGVGKTSLGKSIA 373
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
 316-340 7.69e-03

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 38.52  E-value: 7.69e-03
                         10        20
                 ....*....|....*....|....*....
gi 767999369 316 LLLYGPPGTGKTLLAKAVATE----CKTT 340
Cdd:COG2255   57 VLLYGPPGLGKTTLAHIIANEmgvnIRIT 85
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
 316-340 8.94e-03

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 38.05  E-value: 8.94e-03
                          10        20
                  ....*....|....*....|....*....
gi 767999369  316 LLLYGPPGTGKTLLAKAVA----TECKTT 340
Cdd:TIGR00635  33 LLLYGPPGLGKTTLAHIIAnemgVNLKIT 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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