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Conserved domains on  [gi|767996244|ref|XP_011523690|]
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coronin-6 isoform X3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-427 4.23e-96

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 297.57  E-value: 4.23e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244  80 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 158
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 159 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTG--- 235
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGkav 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 236 EVLLSlddmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGMRPMRAVFT-RQGHIFTTGFTRMSQ 314
Cdd:PTZ00421 162 EVIKC----HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 315 RELGLWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPK 394
Cdd:PTZ00421 237 RQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPK 314

                        330       340       350
                 ....*....|....*....|....*....|...
gi 767996244 395 RGLDVSKCEIARFYKLHERKCEPIIMTVPRKTS 427
Cdd:PTZ00421 315 WSLDTRKCEIARFYALTYHSLYTIQMLLPRKQA 347
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 80-427 4.23e-96

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 297.57  E-value: 4.23e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244  80 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 158
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 159 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTG--- 235
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGkav 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 236 EVLLSlddmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGMRPMRAVFT-RQGHIFTTGFTRMSQ 314
Cdd:PTZ00421 162 EVIKC----HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 315 RELGLWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPK 394
Cdd:PTZ00421 237 RQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPK 314

                        330       340       350
                 ....*....|....*....|....*....|...
gi 767996244 395 RGLDVSKCEIARFYKLHERKCEPIIMTVPRKTS 427
Cdd:PTZ00421 315 WSLDTRKCEIARFYALTYHSLYTIQMLLPRKQA 347
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 75-140 2.59e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 124.92  E-value: 2.59e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996244   75 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGR 140
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-367 3.68e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 3.68e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 149 TGHTAPVLDIDWCPHnDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:cd00200   48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmrPMRAV--FTRQGHIFT 306
Cdd:cd00200  119 VWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGHTG--EVNSVafSPDGEKLLS 194

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996244 307 TGftrmSQRELGLWDPNNFEEPVALQEMDtsNGVLLPFYDPDSSIVyLCGKGDSSIRYFEI 367
Cdd:cd00200  195 SS----SDGTIKLWDLSTGKCLGTLRGHE--NGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
148-363 2.13e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 2.13e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 148 VTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 227
Cdd:COG2319  200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-------GKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTV 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 228 IIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGmRPMRAVFTRQGHIFTT 307
Cdd:COG2319  271 RLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTG-AVRSVAFSPDGKTLAS 347

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996244 308 GFtrmSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVYLCGkGDSSIR 363
Cdd:COG2319  348 GS---DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 149-180 2.14e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.14e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767996244   149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 180
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 80-427 4.23e-96

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 297.57  E-value: 4.23e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244  80 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 158
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 159 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTG--- 235
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGkav 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 236 EVLLSlddmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGMRPMRAVFT-RQGHIFTTGFTRMSQ 314
Cdd:PTZ00421 162 EVIKC----HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 315 RELGLWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPK 394
Cdd:PTZ00421 237 RQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPK 314

                        330       340       350
                 ....*....|....*....|....*....|...
gi 767996244 395 RGLDVSKCEIARFYKLHERKCEPIIMTVPRKTS 427
Cdd:PTZ00421 315 WSLDTRKCEIARFYALTYHSLYTIQMLLPRKQA 347
PTZ00420 PTZ00420
coronin; Provisional
 92-429 9.51e-62

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 209.81  E-value: 9.51e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244  92 ADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGRvdkNYPLVT--GHTAPVLDIDWCPHNDNVIA 169
Cdd:PTZ00420  15 SNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR---KPPVIKlkGHTSSILDLQFNPCFSEILA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 170 SASDDTTIMVWQIP-DYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLddMHPDV 248
Cdd:PTZ00420  92 SGSEDLTIRVWEIPhNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQI--NMPKK 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 249 IHSVCWNSNGSLLATTCKDKTLRIIDPRKgQVVAERFAAHEGMRPMRAVFT-----RQGHIFTTGFTRMSQRELGLWDPN 323
Cdd:PTZ00420 170 LSSLKWNIKGNLLSGTCVGKHMHIIDPRK-QEIASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKLWDLK 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 324 NFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPpfVHYLNTFSSKEPQRGMGFMPKRGLDVSKCE 403
Cdd:PTZ00420 249 NTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCE 326

                        330       340
                 ....*....|....*....|....*..
gi 767996244 404 IARFYK-LHERKCEPIIMTVPRKTSSR 429
Cdd:PTZ00420 327 IGRVYKnENNSSIRPISFYVPRKNPTK 353
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 75-140 2.59e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 124.92  E-value: 2.59e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767996244   75 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGR 140
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-367 3.68e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 3.68e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 149 TGHTAPVLDIDWCPHnDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:cd00200   48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmrPMRAV--FTRQGHIFT 306
Cdd:cd00200  119 VWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGHTG--EVNSVafSPDGEKLLS 194

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996244 307 TGftrmSQRELGLWDPNNFEEPVALQEMDtsNGVLLPFYDPDSSIVyLCGKGDSSIRYFEI 367
Cdd:cd00200  195 SS----SDGTIKLWDLSTGKCLGTLRGHE--NGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
148-363 2.13e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 2.13e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 148 VTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 227
Cdd:COG2319  200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-------GKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTV 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 228 IIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGmRPMRAVFTRQGHIFTT 307
Cdd:COG2319  271 RLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTG-AVRSVAFSPDGKTLAS 347

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996244 308 GFtrmSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVYLCGkGDSSIR 363
Cdd:COG2319  348 GS---DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-366 5.87e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 109.35  E-value: 5.87e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 106 WDSSFCAVNPKFLAiiveAGGGGAFIVLPLaKTGRVDKNYplvTGHTAPVLDIDWCPHNDnVIASASDDTTIMVWQIPDY 185
Cdd:cd00200   55 RDVAASADGTYLAS----GSSDKTIRLWDL-ETGECVRTL---TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 186 tpmrnitEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTC 265
Cdd:cd00200  126 -------KCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSS 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 266 KDKTLRIIDPRKGQVVAErFAAHEGmRPMRAVFTRQGHIFTTGFtrmSQRELGLWDPNNFEEPVALQEmdTSNGVLLPFY 345
Cdd:cd00200  197 SDGTIKLWDLSTGKCLGT-LRGHEN-GVNSVAFSPDGYLLASGS---EDGTIRVWDLRTGECVQTLSG--HTNSVTSLAW 269

                        250       260
                 ....*....|....*....|.
gi 767996244 346 DPDSSIVYLCGKgDSSIRYFE 366
Cdd:cd00200  270 SPDGKRLASGSA-DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
149-369 9.55e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 9.55e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:COG2319  117 TGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLAT-------GKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 229 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTTG 308
Cdd:COG2319  188 LWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR-TLTGHSG-SVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767996244 309 ftrMSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVyLCGKGDSSIRYFEITD 369
Cdd:COG2319  265 ---SADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
148-363 1.91e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 1.91e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 148 VTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 227
Cdd:COG2319   74 LLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLAT-------GLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 228 IIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTT 307
Cdd:COG2319  145 RLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR-TLTGHTG-AVRSVAFSPDGKLLAS 221

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996244 308 GFtrmSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVYLCGkGDSSIR 363
Cdd:COG2319  222 GS---ADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGRLLASGS-ADGTVR 271
WD40 COG2319
WD40 repeat [General function prediction only];
147-276 2.06e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 2.06e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 147 LVTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDYTPMRnitepiiTLEGHSKRVGILSWHPTARnVLLSAGGDNV 226
Cdd:COG2319  283 TLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLR-------TLTGHTGAVRSVAFSPDGK-TLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767996244 227 IIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPR 276
Cdd:COG2319  354 VRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 194-363 3.37e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 3.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 194 PIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRII 273
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 274 DPRKGQVVAErFAAHEGmrPMRAV-FTRQGHIFTTGftrMSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIV 352
Cdd:cd00200   79 DLETGECVRT-LTGHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGTFV 150

                        170
                 ....*....|.
gi 767996244 353 YlCGKGDSSIR 363
Cdd:cd00200  151 A-SSSQDGTIK 160
WD40 COG2319
WD40 repeat [General function prediction only];
149-234 3.97e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.55  E-value: 3.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 228
Cdd:COG2319  327 TGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT-------GELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVR 397


                 ....*.
gi 767996244 229 IWNVGT 234
Cdd:COG2319  398 LWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 245-369 6.52e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 6.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 245 HPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmrPMRAV-FTRQGH-IFTTGFTRMSQrelgLWDP 322
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKGHTG--PVRDVaASADGTyLASGSSDKTIR----LWDL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767996244 323 NNFEEPVALqEMDTSnGVLLPFYDPDSSIVyLCGKGDSSIRYFEITD 369
Cdd:cd00200   81 ETGECVRTL-TGHTS-YVSSVAFSPDGRIL-SSSSRDKTIKVWDVET 124
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 149-180 2.14e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.14e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767996244   149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 180
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 234-274 4.12e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767996244   234 TGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIID 274
Cdd:smart00320   1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 160-257 8.90e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.81  E-value: 8.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244  160 WCPHNDnVIASASDDTTI--------MVWQIPdytpmrnitepiitLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWN 231
Cdd:pfam12894   3 WCPTMD-LIALATEDGELllhrlnwqRVWTLS--------------PDKEDLEVTSLAWRPDGK-LLAVGYSDGTVRLLD 66

                          90       100
                  ....*....|....*....|....*.
gi 767996244  232 VGTGEVLLSLdDMHPDVIHSVCWNSN 257
Cdd:pfam12894  67 AENGKIVHHF-SAGSDLITCLGWGEN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-231 1.39e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.39e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767996244   193 EPIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 231
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
149-180 2.55e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.55e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767996244  149 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 180
Cdd:pfam00400   8 EGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
245-274 1.44e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.44e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 767996244  245 HPDVIHSVCWNSNGSLLATTCKDKTLRIID 274
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
193-231 1.48e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767996244  193 EPIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 231
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
189-324 2.70e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 2.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767996244 189 RNITEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDK 268
Cdd:COG2319   23 AALGALLLLLLGLAAAVASLAASPDGA-RLAAGAGDLTLLLLDAAAGALLATLLG-HTAAVLSVAFSPDGRLLASASADG 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767996244 269 TLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTTGFtrmSQRELGLWDPNN 324
Cdd:COG2319  101 TVRLWDLATGLLLR-TLTGHTG-AVRSVAFSPDGKTLASGS---ADGTVRLWDLAT 151
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 249-281 3.96e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 3.96e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767996244  249 IHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVV 281
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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