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Conserved domains on  [gi|767987785|ref|XP_011521023|]
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regulator of G-protein signaling 11 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGS_DHEX super family cl39527
Regulator of G-protein signalling DHEX domain; This domain is found in RGS9 (Class C) ...
 140-239 7.60e-36

Regulator of G-protein signalling DHEX domain; This domain is found in RGS9 (Class C) regulator of G-protein signalling (RGS) protein present in Mus musculus. RGS proteins attenuate heterotrimeric G-protein signalling by enhancing the intrinsic GTPase activity of G-alpha subunits and are vital for proper signal transduction kinetics. The domain is referred to as DEP helical extension (DHEX) because it is located next to N-terminal Dishevelled/Egl-10/Pleckstrin homology (DEP) domain. Both the DEP and DHEX domains are necessary, but not sufficient, to bind anchoring proteins such as RGS9 anchor protein. DHEX has no close structural homologs. This domain is also found in regulator of G-protein signaling 7 (RGS7), the crystal structure of which has been solved.


The actual alignment was detected with superfamily member pfam18148:

Pssm-ID: 375589  Cd Length: 100  Bit Score: 124.57  E-value: 7.60e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987785  140 PYFWTSTLRPAAELDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRLVIACQEQ 219
Cdd:pfam18148   1 PYFWPSQAWEPENTDYAIYLAKRNMRNKQRLEEYEKEAYNKLQKKLNYKWDFIIMQAEEQYKVGKERNKADRYILDSQER 80

                          90       100
                  ....*....|....*....|
gi 767987785  220 TYWLVNRPPPGAPDVLEQGP 239
Cdd:pfam18148  81 AFWLVHRPPPGQVNVLEYGI 100
DEP_RGS7-like cd04450
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein ...
 24-106 3.18e-30

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, a DEP domain and a GGL (G-protein gamma subunit-like ) domain. RGS proteins are GTPase-activating (GAP) proteins of heterotrimeric G proteins by increasing the rate of GTP hydrolysis of the alpha subunit. The fungal homologs, like yeast Sst2, share a related common domain architecture, containing RGS and DEP domains. Sst2 has been identified as the principal regulator of mating pheromone signaling and recently the DEP domain of Sst2 has been shown to be necessary and sufficient to mediate receptor interaction.


:

Pssm-ID: 239897  Cd Length: 88  Bit Score: 109.69  E-value: 3.18e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987785  24 RVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQWLAQKF-CVSEEEALHLGAVLVQHGYIYPLRDPRSLmLRPDETP 102
Cdd:cd04450    1 DSVGQMQDSEVGVRMRTEKSFLTTVPYAFTGKAIVQWLMDCTdVVDPSEALEIAALFVKYGLITPVSDHRSL-LKPDETL 79


                 ....
gi 767987785 103 YRFQ 106
Cdd:cd04450   80 YRFQ 83
 
Name Accession Description Interval E-value
RGS_DHEX pfam18148
Regulator of G-protein signalling DHEX domain; This domain is found in RGS9 (Class C) ...
 140-239 7.60e-36

Regulator of G-protein signalling DHEX domain; This domain is found in RGS9 (Class C) regulator of G-protein signalling (RGS) protein present in Mus musculus. RGS proteins attenuate heterotrimeric G-protein signalling by enhancing the intrinsic GTPase activity of G-alpha subunits and are vital for proper signal transduction kinetics. The domain is referred to as DEP helical extension (DHEX) because it is located next to N-terminal Dishevelled/Egl-10/Pleckstrin homology (DEP) domain. Both the DEP and DHEX domains are necessary, but not sufficient, to bind anchoring proteins such as RGS9 anchor protein. DHEX has no close structural homologs. This domain is also found in regulator of G-protein signaling 7 (RGS7), the crystal structure of which has been solved.


Pssm-ID: 375589  Cd Length: 100  Bit Score: 124.57  E-value: 7.60e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987785  140 PYFWTSTLRPAAELDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRLVIACQEQ 219
Cdd:pfam18148   1 PYFWPSQAWEPENTDYAIYLAKRNMRNKQRLEEYEKEAYNKLQKKLNYKWDFIIMQAEEQYKVGKERNKADRYILDSQER 80

                          90       100
                  ....*....|....*....|
gi 767987785  220 TYWLVNRPPPGAPDVLEQGP 239
Cdd:pfam18148  81 AFWLVHRPPPGQVNVLEYGI 100
DEP_RGS7-like cd04450
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein ...
 24-106 3.18e-30

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, a DEP domain and a GGL (G-protein gamma subunit-like ) domain. RGS proteins are GTPase-activating (GAP) proteins of heterotrimeric G proteins by increasing the rate of GTP hydrolysis of the alpha subunit. The fungal homologs, like yeast Sst2, share a related common domain architecture, containing RGS and DEP domains. Sst2 has been identified as the principal regulator of mating pheromone signaling and recently the DEP domain of Sst2 has been shown to be necessary and sufficient to mediate receptor interaction.


Pssm-ID: 239897  Cd Length: 88  Bit Score: 109.69  E-value: 3.18e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987785  24 RVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQWLAQKF-CVSEEEALHLGAVLVQHGYIYPLRDPRSLmLRPDETP 102
Cdd:cd04450    1 DSVGQMQDSEVGVRMRTEKSFLTTVPYAFTGKAIVQWLMDCTdVVDPSEALEIAALFVKYGLITPVSDHRSL-LKPDETL 79


                 ....
gi 767987785 103 YRFQ 106
Cdd:cd04450   80 YRFQ 83
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 32-107 7.11e-21

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 84.64  E-value: 7.11e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767987785    32 PDQGVKMRSQRLLVTVIPHAVTGSDVVQWLAQKFCVSE-EEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQE 107
Cdd:smart00049   1 PETGLKLRDRKYFLKTYPNCFTGSELVDWLMDNLEIIDrEEAVHLGQLLLDEGLIHHVNGPNKHTFKDSKALYRFTT 77
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 35-105 5.98e-18

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 76.47  E-value: 5.98e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767987785   35 GVKMRSQRLLVTVIPHAVTGSDVVQWLAQKFCVSE-EEALHLGAVLVQHGYIYPLRDPRSlMLRPDETPYRF 105
Cdd:pfam00610   1 GVKLKDRRKHLKTYPNCFTGSEAVDWLMDNLEIITrEEAVELGQLLLDQGLIHHVGDKHG-LFKDSYYFYRF 71
 
Name Accession Description Interval E-value
RGS_DHEX pfam18148
Regulator of G-protein signalling DHEX domain; This domain is found in RGS9 (Class C) ...
 140-239 7.60e-36

Regulator of G-protein signalling DHEX domain; This domain is found in RGS9 (Class C) regulator of G-protein signalling (RGS) protein present in Mus musculus. RGS proteins attenuate heterotrimeric G-protein signalling by enhancing the intrinsic GTPase activity of G-alpha subunits and are vital for proper signal transduction kinetics. The domain is referred to as DEP helical extension (DHEX) because it is located next to N-terminal Dishevelled/Egl-10/Pleckstrin homology (DEP) domain. Both the DEP and DHEX domains are necessary, but not sufficient, to bind anchoring proteins such as RGS9 anchor protein. DHEX has no close structural homologs. This domain is also found in regulator of G-protein signaling 7 (RGS7), the crystal structure of which has been solved.


Pssm-ID: 375589  Cd Length: 100  Bit Score: 124.57  E-value: 7.60e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987785  140 PYFWTSTLRPAAELDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRLVIACQEQ 219
Cdd:pfam18148   1 PYFWPSQAWEPENTDYAIYLAKRNMRNKQRLEEYEKEAYNKLQKKLNYKWDFIIMQAEEQYKVGKERNKADRYILDSQER 80

                          90       100
                  ....*....|....*....|
gi 767987785  220 TYWLVNRPPPGAPDVLEQGP 239
Cdd:pfam18148  81 AFWLVHRPPPGQVNVLEYGI 100
DEP_RGS7-like cd04450
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein ...
 24-106 3.18e-30

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, a DEP domain and a GGL (G-protein gamma subunit-like ) domain. RGS proteins are GTPase-activating (GAP) proteins of heterotrimeric G proteins by increasing the rate of GTP hydrolysis of the alpha subunit. The fungal homologs, like yeast Sst2, share a related common domain architecture, containing RGS and DEP domains. Sst2 has been identified as the principal regulator of mating pheromone signaling and recently the DEP domain of Sst2 has been shown to be necessary and sufficient to mediate receptor interaction.


Pssm-ID: 239897  Cd Length: 88  Bit Score: 109.69  E-value: 3.18e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987785  24 RVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQWLAQKF-CVSEEEALHLGAVLVQHGYIYPLRDPRSLmLRPDETP 102
Cdd:cd04450    1 DSVGQMQDSEVGVRMRTEKSFLTTVPYAFTGKAIVQWLMDCTdVVDPSEALEIAALFVKYGLITPVSDHRSL-LKPDETL 79


                 ....
gi 767987785 103 YRFQ 106
Cdd:cd04450   80 YRFQ 83
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 32-107 7.11e-21

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 84.64  E-value: 7.11e-21
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767987785    32 PDQGVKMRSQRLLVTVIPHAVTGSDVVQWLAQKFCVSE-EEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQE 107
Cdd:smart00049   1 PETGLKLRDRKYFLKTYPNCFTGSELVDWLMDNLEIIDrEEAVHLGQLLLDEGLIHHVNGPNKHTFKDSKALYRFTT 77
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 35-105 5.98e-18

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 76.47  E-value: 5.98e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767987785   35 GVKMRSQRLLVTVIPHAVTGSDVVQWLAQKFCVSE-EEALHLGAVLVQHGYIYPLRDPRSlMLRPDETPYRF 105
Cdd:pfam00610   1 GVKLKDRRKHLKTYPNCFTGSEAVDWLMDNLEIITrEEAVELGQLLLDQGLIHHVGDKHG-LFKDSYYFYRF 71
DEP cd04371
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ...
 24-104 1.19e-16

DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction.


Pssm-ID: 239836  Cd Length: 81  Bit Score: 73.53  E-value: 1.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767987785  24 RVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQWLAQKF-CVSEEEALHLGAVLVQHGYIYPLRDPRSLmLRPDETP 102
Cdd:cd04371    1 DLVRIMLDSDSGVPIKDRKYHLKTYPNCFTGSELVDWLLDNLeAITREEAVELGQALLKHGLIHHVSDDKHT-FRDSYAL 79


                 ..
gi 767987785 103 YR 104
Cdd:cd04371   80 YR 81
DEP_PLEK1 cd04445
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins. ...
 27-90 6.32e-06

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins. Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation, mainly by protein kinase C. Pleckstrin-like proteins contain a central DEP domain, flanked by 2 PH (pleckstrin homology) domains.


Pssm-ID: 239892  Cd Length: 99  Bit Score: 44.07  E-value: 6.32e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767987785  27 VSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQWL-AQKFCVSEEEALHLGAVLVQHGYIYPLRD 90
Cdd:cd04445    7 LSMKDPEKGIKELNLEKDKKVFNHCFTGSCVIDWLvSNQSVRNRQEGLMLASSLLNEGYLQPAGD 71
DEP_1_P-Rex cd04439
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex ...
 34-105 1.10e-04

DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF activity is stimulated by phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3), a lipid second messenger, and by the G beta-gamma subunits of heterotrimeric G proteins. The DEP domains are not involved in mediating these stimuli, but may be of importance for basal and stimulated levels Rac-GEF activity.


Pssm-ID: 239886  Cd Length: 81  Bit Score: 40.24  E-value: 1.10e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767987785  34 QGVKMRSQRLLVTVIPHAVTGSDVVQWLAQKFCVSE-EEALHLGAVLVQHGYIYPLRDPRSlmLRPDETPYRF 105
Cdd:cd04439   11 QGSLIKDRRRKLSTFPKCFLGNEFVSWLLEIGEISKpEEGVNLGQALLENGIIHHVSDKHQ--FKNEQVLYRF 81
DEP_dishevelled cd04438
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. ...
 25-85 4.14e-04

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway for cellular development and growth. They contain an N-terminal DIX domain, a central PDZ domain, and a C-terminal DEP domain.


Pssm-ID: 239885  Cd Length: 84  Bit Score: 38.48  E-value: 4.14e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767987785  25 VVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQWLAQKFCVSEE--EALHLGAVLVQHGYI 85
Cdd:cd04438    3 IPRVMRRPDSGLEIKDRMWLKITIPNSFIGSDLVDWLLSHVEGLTDrrEARKYASSLLKLGYI 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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