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Conserved domains on  [gi|767978869|ref|XP_011519389|]
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importin-5 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
783-892 1.35e-43

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


:

Pssm-ID: 465881  Cd Length: 110  Bit Score: 153.80  E-value: 1.35e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869   783 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 862
Cdd:pfam18829    1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
                           90       100       110
                   ....*....|....*....|....*....|
gi 767978869   863 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 892
Cdd:pfam18829   81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
Importin_rep_4 pfam18808
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
286-375 1.57e-29

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


:

Pssm-ID: 408579  Cd Length: 90  Bit Score: 112.94  E-value: 1.57e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869   286 DTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMA 365
Cdd:pfam18808    1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
                           90
                   ....*....|
gi 767978869   366 CGLGGKLVLP 375
Cdd:pfam18808   81 CRLGGKALLP 90
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
31-652 2.15e-14

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 78.06  E-value: 2.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869   31 LLLGNLLSPDNVVRKQAEETYENIPG---QSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSS-------AFDEVYPALP 100
Cdd:COG5215     9 LGKNHVLSPDPNARLRAEAQLLELQSgdfEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQRWLGMR 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  101 SDVQTAIKSellMIIQmeTQSSMRKKVCDIAAELARNLID-EDGNNQWPEGLKFLFDSV-SSQNVGLREAALHIFWNF-- 176
Cdd:COG5215    89 HESKEQVKG---MALR--ALKSPEPRFCTMAAQLLAAIARmELPNSLWPGLMEEMVRNVgDEQPVSGKCESLGICGYHce 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  177 ---PGIFGNQQqhylDVIKRMLVQCMQDQEHPSIRTLSARATAA-------FILANEHNVALFkhfadllpgfLQAVNDS 246
Cdd:COG5215   164 seaPEDLIQMS----NVILFAIVMGALKNETTSAVRLAALKALMdslmfvqGNFCYEEERNYF----------MQVVCEA 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  247 CYQNDDSVLKS----LVEIADTVPKYLRPHLEATLqLSLKLCGDTSLNNMQRQLALE--------------VIVTLSETA 308
Cdd:COG5215   230 TQGNDEELQHAafgcLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsticeeeidgemEDKYLPEVP 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  309 AAMLRKHTNIVAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNP 388
Cdd:COG5215   309 AQNHGFARAAVADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSE 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  389 DWKYRHAGLMALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQ 466
Cdd:COG5215   379 SWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLI 458
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  467 TMEDqgNQRVQAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADT 540
Cdd:COG5215   459 GLMD--CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDA 534
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  541 AEEKFVPYYDLFMPSLKHIVEN-----AVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDM 612
Cdd:COG5215   535 VSDILAGFYDYTSKKLDECISVlgqilATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTA 614
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 767978869  613 EDDdpqISYMISAwarMCKILGKEFQQYLPVVMgPLMKTA 652
Cdd:COG5215   615 FGD---VYTAISA---LSTSLEERFEQYASKFI-PYLTRA 647
Importin_rep_5 super family cl40106
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
1023-1069 3.09e-06

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.


The actual alignment was detected with superfamily member pfam18816:

Pssm-ID: 465877  Cd Length: 52  Bit Score: 45.16  E-value: 3.09e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 767978869  1023 DKEEAVQTFNYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 1069
Cdd:pfam18816    1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
937-984 6.39e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


:

Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 6.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767978869   937 PEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENV 984
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
 
Name Accession Description Interval E-value
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
783-892 1.35e-43

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


Pssm-ID: 465881  Cd Length: 110  Bit Score: 153.80  E-value: 1.35e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869   783 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 862
Cdd:pfam18829    1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
                           90       100       110
                   ....*....|....*....|....*....|
gi 767978869   863 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 892
Cdd:pfam18829   81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
Importin_rep_4 pfam18808
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
286-375 1.57e-29

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


Pssm-ID: 408579  Cd Length: 90  Bit Score: 112.94  E-value: 1.57e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869   286 DTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMA 365
Cdd:pfam18808    1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
                           90
                   ....*....|
gi 767978869   366 CGLGGKLVLP 375
Cdd:pfam18808   81 CRLGGKALLP 90
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
31-652 2.15e-14

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 78.06  E-value: 2.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869   31 LLLGNLLSPDNVVRKQAEETYENIPG---QSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSS-------AFDEVYPALP 100
Cdd:COG5215     9 LGKNHVLSPDPNARLRAEAQLLELQSgdfEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQRWLGMR 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  101 SDVQTAIKSellMIIQmeTQSSMRKKVCDIAAELARNLID-EDGNNQWPEGLKFLFDSV-SSQNVGLREAALHIFWNF-- 176
Cdd:COG5215    89 HESKEQVKG---MALR--ALKSPEPRFCTMAAQLLAAIARmELPNSLWPGLMEEMVRNVgDEQPVSGKCESLGICGYHce 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  177 ---PGIFGNQQqhylDVIKRMLVQCMQDQEHPSIRTLSARATAA-------FILANEHNVALFkhfadllpgfLQAVNDS 246
Cdd:COG5215   164 seaPEDLIQMS----NVILFAIVMGALKNETTSAVRLAALKALMdslmfvqGNFCYEEERNYF----------MQVVCEA 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  247 CYQNDDSVLKS----LVEIADTVPKYLRPHLEATLqLSLKLCGDTSLNNMQRQLALE--------------VIVTLSETA 308
Cdd:COG5215   230 TQGNDEELQHAafgcLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsticeeeidgemEDKYLPEVP 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  309 AAMLRKHTNIVAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNP 388
Cdd:COG5215   309 AQNHGFARAAVADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSE 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  389 DWKYRHAGLMALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQ 466
Cdd:COG5215   379 SWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLI 458
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  467 TMEDqgNQRVQAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADT 540
Cdd:COG5215   459 GLMD--CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDA 534
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  541 AEEKFVPYYDLFMPSLKHIVEN-----AVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDM 612
Cdd:COG5215   535 VSDILAGFYDYTSKKLDECISVlgqilATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTA 614
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 767978869  613 EDDdpqISYMISAwarMCKILGKEFQQYLPVVMgPLMKTA 652
Cdd:COG5215   615 FGD---VYTAISA---LSTSLEERFEQYASKFI-PYLTRA 647
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
390-444 4.16e-09

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 53.52  E-value: 4.16e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767978869   390 WKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQM 444
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
Importin_rep_5 pfam18816
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
1023-1069 3.09e-06

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.


Pssm-ID: 465877  Cd Length: 52  Bit Score: 45.16  E-value: 3.09e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 767978869  1023 DKEEAVQTFNYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 1069
Cdd:pfam18816    1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
937-984 6.39e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 6.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767978869   937 PEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENV 984
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
 
Name Accession Description Interval E-value
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
783-892 1.35e-43

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


Pssm-ID: 465881  Cd Length: 110  Bit Score: 153.80  E-value: 1.35e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869   783 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 862
Cdd:pfam18829    1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
                           90       100       110
                   ....*....|....*....|....*....|
gi 767978869   863 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 892
Cdd:pfam18829   81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
Importin_rep_4 pfam18808
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
286-375 1.57e-29

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


Pssm-ID: 408579  Cd Length: 90  Bit Score: 112.94  E-value: 1.57e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869   286 DTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMA 365
Cdd:pfam18808    1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
                           90
                   ....*....|
gi 767978869   366 CGLGGKLVLP 375
Cdd:pfam18808   81 CRLGGKALLP 90
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
31-652 2.15e-14

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 78.06  E-value: 2.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869   31 LLLGNLLSPDNVVRKQAEETYENIPG---QSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSS-------AFDEVYPALP 100
Cdd:COG5215     9 LGKNHVLSPDPNARLRAEAQLLELQSgdfEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQRWLGMR 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  101 SDVQTAIKSellMIIQmeTQSSMRKKVCDIAAELARNLID-EDGNNQWPEGLKFLFDSV-SSQNVGLREAALHIFWNF-- 176
Cdd:COG5215    89 HESKEQVKG---MALR--ALKSPEPRFCTMAAQLLAAIARmELPNSLWPGLMEEMVRNVgDEQPVSGKCESLGICGYHce 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  177 ---PGIFGNQQqhylDVIKRMLVQCMQDQEHPSIRTLSARATAA-------FILANEHNVALFkhfadllpgfLQAVNDS 246
Cdd:COG5215   164 seaPEDLIQMS----NVILFAIVMGALKNETTSAVRLAALKALMdslmfvqGNFCYEEERNYF----------MQVVCEA 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  247 CYQNDDSVLKS----LVEIADTVPKYLRPHLEATLqLSLKLCGDTSLNNMQRQLALE--------------VIVTLSETA 308
Cdd:COG5215   230 TQGNDEELQHAafgcLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsticeeeidgemEDKYLPEVP 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  309 AAMLRKHTNIVAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNP 388
Cdd:COG5215   309 AQNHGFARAAVADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSE 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  389 DWKYRHAGLMALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQ 466
Cdd:COG5215   379 SWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLI 458
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  467 TMEDqgNQRVQAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADT 540
Cdd:COG5215   459 GLMD--CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDA 534
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  541 AEEKFVPYYDLFMPSLKHIVEN-----AVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDM 612
Cdd:COG5215   535 VSDILAGFYDYTSKKLDECISVlgqilATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTA 614
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 767978869  613 EDDdpqISYMISAwarMCKILGKEFQQYLPVVMgPLMKTA 652
Cdd:COG5215   615 FGD---VYTAISA---LSTSLEERFEQYASKFI-PYLTRA 647
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
390-444 4.16e-09

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 53.52  E-value: 4.16e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767978869   390 WKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQM 444
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
370-484 9.37e-09

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 55.02  E-value: 9.37e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  370 GKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfa 449
Cdd:COG1413    41 GRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGD----------PEAVPALIAALKDEDPEVRRAAAEALGRLGD--- 107
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 767978869  450 pgfqkkfhEKVIAALLQTMEDQgNQRVQAHAAAAL 484
Cdd:COG1413   108 --------PAAVPALLEALKDP-DWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
379-502 5.58e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 52.71  E-value: 5.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  379 EHIMQMLQNPDWKYRHAGLMALSAIGEGchqqmegilnEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfapgfqkkfhE 458
Cdd:COG1413    19 PALIAALADEDPDVRAAAARALGRLGDP----------RAVPALLEALKDPDPEVRAAAAEALGRIGD-----------P 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 767978869  459 KVIAALLQTMEDQgNQRVQAHAAAALINFTEDCPKSLLIPYLDN 502
Cdd:COG1413    78 EAVPALIAALKDE-DPEVRRAAAEALGRLGDPAAVPALLEALKD 120
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
383-484 1.34e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 50.41  E-value: 1.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869   383 QMLQNPDWKYRHAGLMALSAIGEGchqqmegilnEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfapgfqkkfhEKVIA 462
Cdd:pfam13646    7 ALLRDPDPEVRAAAIRALGRIGDP----------EAVPALLELLKDEDPAVRRAAAEALGKIGD-----------PEALP 65
                           90       100
                   ....*....|....*....|..
gi 767978869   463 ALLQTMEDQGNQRVQAHAAAAL 484
Cdd:pfam13646   66 ALLELLRDDDDDVVRAAAAEAL 87
Importin_rep_5 pfam18816
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
1023-1069 3.09e-06

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.


Pssm-ID: 465877  Cd Length: 52  Bit Score: 45.16  E-value: 3.09e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 767978869  1023 DKEEAVQTFNYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 1069
Cdd:pfam18816    1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
Vac14_Fab1_bd pfam12755
Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex ...
392-440 1.42e-05

Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.


Pssm-ID: 403838  Cd Length: 97  Bit Score: 44.89  E-value: 1.42e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 767978869   392 YRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNA 440
Cdd:pfam12755    2 ARKGGLIGLAATAIALGKDIAPYLDDIIPPVLACFSDQDSRVRYYACES 50
HEAT COG1413
HEAT repeat [General function prediction only];
393-502 9.01e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.46  E-value: 9.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767978869  393 RHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMAtdfapgfqkkfHEKVIAALLQTMEDQg 472
Cdd:COG1413     2 RRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKDP- 59
                          90       100       110
                  ....*....|....*....|....*....|
gi 767978869  473 NQRVQAHAAAALINFTEDCPKSLLIPYLDN 502
Cdd:COG1413    60 DPEVRAAAAEALGRIGDPEAVPALIAALKD 89
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
418-445 5.56e-04

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 38.28  E-value: 5.56e-04
                           10        20
                   ....*....|....*....|....*...
gi 767978869   418 IVNFVLLFLQDPHPRVRYAACNAVGQMA 445
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELA 28
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
937-984 6.39e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 6.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767978869   937 PEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENV 984
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
431-487 1.18e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.12  E-value: 1.18e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767978869   431 PRVRYAACNAVGQMAtDFAPGFQKKFHEKVIAALLQTMEDqGNQRVQAHAAAALINF 487
Cdd:pfam13513    1 WRVREAAALALGSLA-EGGPDLLAPAVPELLPALLPLLND-DSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
379-445 1.43e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 1.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767978869  379 EHIMQMLQNPDWKYRHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMA 445
Cdd:COG1413    81 PALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDPDWEVRRAAARALGRLG 137
IBN_N pfam03810
Importin-beta N-terminal domain;
62-112 2.69e-03

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 37.60  E-value: 2.69e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767978869    62 FLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELL 112
Cdd:pfam03810   17 KLLQILSNSENPLEVRQLAALYLKNLITRHWEEEKNSLPPEEKEQIKNNLL 67
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
924-953 5.44e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.58  E-value: 5.44e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 767978869   924 FLRPMLQYVCDNSPEVRQAAAYGLGVMAQY 953
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELAEV 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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