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Conserved domains on  [gi|767973034|ref|XP_011536151|]
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proton myo-inositol cotransporter isoform X4 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
87-414 8.87e-147

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17360:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 362  Bit Score: 422.45  E-value: 8.87e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  87 FSALGGFLFGYDTGVVSGAMLLLKRQL---SLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSA 163
Cdd:cd17360    1 FAGIGGFLFGYDTGVISGALLYIKDDLgevVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 164 VLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLqKDGWRYMLG 243
Cdd:cd17360   81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYL-PGGWRWMLG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 244 LAAVPAVIQFFGFLFLPESPRWliqkgqtqkarrilsqmrgnqtideeydsiknnieeeekevgsagpvicrmlsyPPTR 323
Cdd:cd17360  160 LAAVPAVLQFIGLLFLPESPRW------------------------------------------------------PSTR 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 324 RALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTV 403
Cdd:cd17360  186 RALIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIV 265
                        330
                 ....*....|.
gi 767973034 404 ALIILALGFVL 414
Cdd:cd17360  266 ALVVLAVWLAL 276
 
Name Accession Description Interval E-value
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
87-414 8.87e-147

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 422.45  E-value: 8.87e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  87 FSALGGFLFGYDTGVVSGAMLLLKRQL---SLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSA 163
Cdd:cd17360    1 FAGIGGFLFGYDTGVISGALLYIKDDLgevVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 164 VLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLqKDGWRYMLG 243
Cdd:cd17360   81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYL-PGGWRWMLG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 244 LAAVPAVIQFFGFLFLPESPRWliqkgqtqkarrilsqmrgnqtideeydsiknnieeeekevgsagpvicrmlsyPPTR 323
Cdd:cd17360  160 LAAVPAVLQFIGLLFLPESPRW------------------------------------------------------PSTR 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 324 RALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTV 403
Cdd:cd17360  186 RALIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIV 265
                        330
                 ....*....|.
gi 767973034 404 ALIILALGFVL 414
Cdd:cd17360  266 ALVVLAVWLAL 276
Sugar_tr pfam00083
Sugar (and other) transporter;
84-412 4.50e-82

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 260.28  E-value: 4.50e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034   84 VAVFSALGGFLFGYDTGVVSGAMLLLKRQ-----------LSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAIL 152
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIDFFknfglsksvssLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  153 LASALFTAGSAVLAAANNKET---LLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGA 229
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  230 FS-YLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRG----NQTIDEEYDSIKNNIEEEEK 304
Cdd:pfam00083 161 LNkTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGvpdvDRELDEIKDSLEAGQEAEKA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  305 EVGSagpvicrMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWLASVtafTNFIFTLVGVWL 384
Cdd:pfam00083 241 SWKE-------LFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGV---VNFVFTFIAIFL 310
                         330       340
                  ....*....|....*....|....*...
gi 767973034  385 VEKVGRRKLTFGSLAGTTVALIILALGF 412
Cdd:pfam00083 311 VDRFGRRPLLLLGAAGMAICFVILGIVA 338
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
80-409 3.15e-75

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 243.40  E-value: 3.15e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034   80 FVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQL--------SLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAI 151
Cdd:TIGR00879  25 KVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFkftsansdSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSL 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  152 LLASALFTAGSAVLAAANNK---ETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVD- 227
Cdd:TIGR00879 105 LIIALLFVIGAILMGLAAFAlsvEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGs 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  228 GAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGN----QTIDEEYDSIKNNIEEEE 303
Cdd:TIGR00879 185 GKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTsgedKELLDELELIDIKRSIEK 264
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  304 KEVGSAGPviCRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDrLAIWLASVTAFTNFIFTLVGVW 383
Cdd:TIGR00879 265 RSVQPSWG--SLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTD-HAFLVSIIVGAVNFAFTFVAIF 341
                         330       340
                  ....*....|....*....|....*.
gi 767973034  384 LVEKVGRRKLTFGSLAGTTVALIILA 409
Cdd:TIGR00879 342 LVDRFGRRPLLLIGAAGMAICLFVLG 367
xylE PRK10077
D-xylose transporter XylE; Provisional
79-416 1.73e-49

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 175.27  E-value: 1.73e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  79 AFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAG----GALNGV----FGRRAA 150
Cdd:PRK10077   8 SYIFSITLVATLGGLLFGYDTAVISGTVESLNTVFVAPQNLSESAANSLLGFCVASALIGciigGALGGYcsnrFGRRDS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 151 ILLASALF---TAGSA---VLAAANNKETL------LAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITG 218
Cdd:PRK10077  88 LKIAAVLFfisALGSAwpeFGFTSIGPDNTgyvpefVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIF 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 219 GQFFASVVD------GAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTIDEEY 292
Cdd:PRK10077 168 GQLVVYFVNyfiarsGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLATQAL 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 293 DSIKNNIEEEEKEVGsagpvicRMLSYPPTrrALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDrLAIWLASVTAF 372
Cdd:PRK10077 248 QEIKHSLDHGRKTGG-------KLLMFGVG--VIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGASTD-IALLQTIIVGV 317
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 767973034 373 TNFIFTLVGVWLVEKVGRRKLtfgslagttvaLIILALGFVLSA 416
Cdd:PRK10077 318 INLTFTVLAIMTVDKFGRKPL-----------QIIGALGMAIGM 350
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
77-416 6.94e-28

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 113.53  E-value: 6.94e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  77 TPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASA 156
Cdd:COG2814    4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 157 LFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFsyLQKD 236
Cdd:COG2814   84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL--ADLF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 237 GWRYMLGLAAVPAVIQFF-GFLFLPESPRwliqkgqtQKARRILSQMRgnqtideeydsiknnieeeekevgsagpvicR 315
Cdd:COG2814  162 GWRWVFLVNAVLALLALLlLLRLLPESRP--------AARARLRGSLR-------------------------------E 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 316 MLSYPPTRRALIVGCGLQMfqqlsGINTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTF 395
Cdd:COG2814  203 LLRRPRLLLLLLLAFLLGF-----GFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL 277
                        330       340
                 ....*....|....*....|.
gi 767973034 396 GSLAGTTVALIILALGFVLSA 416
Cdd:COG2814  278 IGLLLLALGLLLLALAGSLWL 298
 
Name Accession Description Interval E-value
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
87-414 8.87e-147

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 422.45  E-value: 8.87e-147
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  87 FSALGGFLFGYDTGVVSGAMLLLKRQL---SLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSA 163
Cdd:cd17360    1 FAGIGGFLFGYDTGVISGALLYIKDDLgevVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 164 VLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLqKDGWRYMLG 243
Cdd:cd17360   81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYL-PGGWRWMLG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 244 LAAVPAVIQFFGFLFLPESPRWliqkgqtqkarrilsqmrgnqtideeydsiknnieeeekevgsagpvicrmlsyPPTR 323
Cdd:cd17360  160 LAAVPAVLQFIGLLFLPESPRW------------------------------------------------------PSTR 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 324 RALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTV 403
Cdd:cd17360  186 RALIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIV 265
                        330
                 ....*....|.
gi 767973034 404 ALIILALGFVL 414
Cdd:cd17360  266 ALVVLAVWLAL 276
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
87-416 3.26e-89

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 275.61  E-value: 3.26e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  87 FSALGGFLFGYDTGVVSGAMLLLKRQL--SLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAV 164
Cdd:cd17315    1 VAALGGLLFGYDLGVINGALLYIAKDLgfGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 165 LAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKDGWRYMLGL 244
Cdd:cd17315   81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 245 AAVPAVIQFFGFLFLPESprwliqkgqtqkarrilsqmrgnqtideeydsiknnieeeekevgsagpvicrmlsypptrR 324
Cdd:cd17315  161 AAVPALLQLLLMFFLPES-------------------------------------------------------------R 179
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 325 ALIVGCGLQMFQQLSGINTIMYYSATILQMSGveDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVA 404
Cdd:cd17315  180 ALLVGVGLQLLQQLTGINAVMYYAPTIFKSAG--GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMAAS 257
                        330
                 ....*....|..
gi 767973034 405 LIILALGFVLSA 416
Cdd:cd17315  258 LLLLAIAFLLPA 269
Sugar_tr pfam00083
Sugar (and other) transporter;
84-412 4.50e-82

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 260.28  E-value: 4.50e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034   84 VAVFSALGGFLFGYDTGVVSGAMLLLKRQ-----------LSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAIL 152
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIDFFknfglsksvssLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  153 LASALFTAGSAVLAAANNKET---LLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGA 229
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  230 FS-YLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRG----NQTIDEEYDSIKNNIEEEEK 304
Cdd:pfam00083 161 LNkTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGvpdvDRELDEIKDSLEAGQEAEKA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  305 EVGSagpvicrMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWLASVtafTNFIFTLVGVWL 384
Cdd:pfam00083 241 SWKE-------LFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDSFLVTIIVGV---VNFVFTFIAIFL 310
                         330       340
                  ....*....|....*....|....*...
gi 767973034  385 VEKVGRRKLTFGSLAGTTVALIILALGF 412
Cdd:pfam00083 311 VDRFGRRPLLLLGAAGMAICFVILGIVA 338
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
84-412 8.64e-82

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 257.11  E-value: 8.64e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  84 VAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSA 163
Cdd:cd17359    2 ISLVAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISAL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 164 VLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVD------GAFSYLQKDG 237
Cdd:cd17359   82 GSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNylianaGGADWLGAEG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 238 WRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGqtqkarrilsqmrgnqtideeydsiknnieeeekevgsagpvicrml 317
Cdd:cd17359  162 WRWMLGLEAIPAILFLLGMLFIPESPRWLVSKG----------------------------------------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 318 sypptRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWlASVTAFTNFIFTLVGVWLVEKVGRRKLTFGS 397
Cdd:cd17359  195 -----KPILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAALLQ-TIGIGVVNVIFTIIAILLVDKVGRKPLLLIG 268
                        330
                 ....*....|....*
gi 767973034 398 LAGTTVALIILALGF 412
Cdd:cd17359  269 SIGMAISLLLIGTAF 283
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
80-409 3.15e-75

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 243.40  E-value: 3.15e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034   80 FVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQL--------SLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAI 151
Cdd:TIGR00879  25 KVALLSLIAAIGGLMFGYDTGVIGGALALPAFEFkftsansdSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSL 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  152 LLASALFTAGSAVLAAANNK---ETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVD- 227
Cdd:TIGR00879 105 LIIALLFVIGAILMGLAAFAlsvEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGs 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  228 GAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGN----QTIDEEYDSIKNNIEEEE 303
Cdd:TIGR00879 185 GKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTsgedKELLDELELIDIKRSIEK 264
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  304 KEVGSAGPviCRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDrLAIWLASVTAFTNFIFTLVGVW 383
Cdd:TIGR00879 265 RSVQPSWG--SLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTD-HAFLVSIIVGAVNFAFTFVAIF 341
                         330       340
                  ....*....|....*....|....*.
gi 767973034  384 LVEKVGRRKLTFGSLAGTTVALIILA 409
Cdd:TIGR00879 342 LVDRFGRRPLLLIGAAGMAICLFVLG 367
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
82-412 4.67e-63

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 210.12  E-value: 4.67e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  82 YVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDalwQELLVS--STVG-----AAAVSALAGGALNGVFGRRAAILLA 154
Cdd:cd17358    1 LLATFVANLGSFSFGIAVGWSSPALPSLMSDNSLS---LPLTVAqfSWFGslltlGALIGALLSGKLADRIGRKRTLLIS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 155 SALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVdGAFSYlq 234
Cdd:cd17358   78 AIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVL-GSFLP-- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 235 kdgWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTIDEEYDSIKNNIEEEEKEvgSAGPVIC 314
Cdd:cd17358  155 ---WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAELEK--EAKESSF 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 315 RMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVE-DDRLAiwlASVTAFTNFIFTLVGVWLVEKVGRRKL 393
Cdd:cd17358  230 SDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGlDPNTA---TIIIGVVQVVGTLVATLLVDRLGRRPL 306
                        330
                 ....*....|....*....
gi 767973034 394 TFGSLAGTTVALIILALGF 412
Cdd:cd17358  307 LLVSAIGMGIGLLALGLYF 325
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
87-410 2.26e-62

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 207.20  E-value: 2.26e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  87 FSALGGFLFGYDTGVVSGAMLLLKRQLSLDALW-------QELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFT 159
Cdd:cd17362    1 FPALGGLLFGYDIGATSGALLSITSPALSGTDWynlsslqSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 160 AGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLqKDGWR 239
Cdd:cd17362   81 VGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADV-VGGWR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 240 YMLGLAAVPAVIQFFGFLFLPESPRWliqkgqtqkarrilsqmrgnqtideeydsiknnieeeekevgsagpvicrmlsY 319
Cdd:cd17362  160 YMYGLAAPPALLLGIGMWFLPPSPRW-----------------------------------------------------Q 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 320 PPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLA 399
Cdd:cd17362  187 GNYRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVS 266
                        330
                 ....*....|.
gi 767973034 400 GTTVALIILAL 410
Cdd:cd17362  267 GMVVSLFLLAA 277
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
87-424 5.11e-58

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 195.70  E-value: 5.11e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  87 FSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLA 166
Cdd:cd17437    1 LASLNSILLGYDIGVMSGAVIFIKEDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 167 AANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYL-QKDGWRYMLGLA 245
Cdd:cd17437   81 VAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSGLpLHVGWRLMLGVG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 246 AVPAVIQFFGFLFLPESPRWLiqkgqtqkarrilsqmrgnqtideeydsiknnieeeekevgsagpvicrmlsyPPTRRA 325
Cdd:cd17437  161 AVPSLFLAIGVLAMPESPRWT-----------------------------------------------------PAVRRM 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 326 LIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRlAIWLASV-TAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVA 404
Cdd:cd17437  188 LIAALGIHFFQQASGIDAVVLYSPRIFKKAGIKSKD-KLLLATVaVGVTKTLFILVATFLLDKVGRRPLLLTSTGGMTLS 266
                        330       340
                 ....*....|....*....|
gi 767973034 405 LIILALGFVLSAQVSPRITF 424
Cdd:cd17437  267 LTALATSLTFIDRNGGGLTW 286
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
85-419 9.65e-55

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 188.70  E-value: 9.65e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  85 AVFSA-LGGFLFGYDTGVVSGAMLLLKR---------------QLSLDALWQeLLVSSTVGAAAVSALAGGALNGVFGRR 148
Cdd:cd17431    2 AVFVAvLGSLQFGYNTGVINAPQKVIEEfynktlgdrygepisPETLTTLWS-LSVAIFSVGGMIGSFSVGLFVNRFGRR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 149 AAILLASALFTAGSAVLA---AANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASV 225
Cdd:cd17431   81 NSMLYNNLLAFAGAALMGlskLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 226 VDGAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWL-IQKGQTQKARRILSQMRGNQTIDEEYDSIKNNIEEEEK 304
Cdd:cd17431  161 FGLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLlINRNEEEEAKSVLKKLRGTTDVSEDIQEMKEESRQMMR 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 305 evgSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWLASVtafTNFIFTLVGVWL 384
Cdd:cd17431  241 ---EKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGAGV---VNTIFTVVSLFL 314
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 767973034 385 VEKVGRRKLTFGSLAGTTVALIILALGFVLSAQVS 419
Cdd:cd17431  315 VERAGRRTLHLIGLGGMAICAILMTIALLLLEGYP 349
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
83-409 1.65e-53

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 183.99  E-value: 1.65e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  83 VVAVFSALGGFLFGYDTGVVSG--AMLLLKRQL-------SLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILL 153
Cdd:cd17356    1 LLCAFVSLGGFLFGYDTGSISGilNMKSFQKYFadntgtyYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 154 ASALFTAGSAVLAAANNKET-LLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSY 232
Cdd:cd17356   81 GCVIYIIGAIIQVAAIGKWYqLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 233 LQKDG-WRYMLGLAAVPAVIQFFGFLFLPESPRWLiqkgqtqkarrilsqmrgnqtideeydsiknnieeeekevgsagp 311
Cdd:cd17356  161 LDGSAqWRIPLGLQIVWGLLLLIGMFFLPESPRWL--------------------------------------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 312 vicrmlsypptrRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDrlAIWLAS-VTAFTNFIFTLVGVWLVEKVGR 390
Cdd:cd17356  196 ------------YRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGS--SPLLTSiILYIVNFVSTIPGLFFVDKFGR 261
                        330
                 ....*....|....*....
gi 767973034 391 RKLTFGSLAGTTVALIILA 409
Cdd:cd17356  262 RTCLLIGAAGMSICLFIYA 280
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
85-420 2.36e-52

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 182.08  E-value: 2.36e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  85 AVFSALGGFLFGYDTGVV---SGAM-------LLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGV----FGRRAA 150
Cdd:cd17357    2 VIVAFGGSFQFGYNIGVVnapQEVFkefindtLVDRYGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFlanrFGRKNG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 151 ILLASALFTAGSAVLAAAN---NKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVD 227
Cdd:cd17357   82 LLISNALLVVSSLLMFLSKsakSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 228 GAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWL-IQKGQTQKARRILSQMRGNQtiDEEYDSIKNNIEEEEKEV 306
Cdd:cd17357  162 LPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLlISKGDEEEAEKSLKFLRGIE--DDVDQELEEIKKESEQMG 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 307 GSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDrLAIWLASVTAFTNFIFTLVGVWLVE 386
Cdd:cd17357  240 DQKQVSLMQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPQ-LAEWANLGIGIVNVLSTIVGPFLIE 318
                        330       340       350
                 ....*....|....*....|....*....|....
gi 767973034 387 KVGRRKLTFGSLAGTTVALIILALGFVLSAQVSP 420
Cdd:cd17357  319 KVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSW 352
xylE PRK10077
D-xylose transporter XylE; Provisional
79-416 1.73e-49

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 175.27  E-value: 1.73e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  79 AFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAG----GALNGV----FGRRAA 150
Cdd:PRK10077   8 SYIFSITLVATLGGLLFGYDTAVISGTVESLNTVFVAPQNLSESAANSLLGFCVASALIGciigGALGGYcsnrFGRRDS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 151 ILLASALF---TAGSA---VLAAANNKETL------LAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITG 218
Cdd:PRK10077  88 LKIAAVLFfisALGSAwpeFGFTSIGPDNTgyvpefVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAIIF 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 219 GQFFASVVD------GAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTIDEEY 292
Cdd:PRK10077 168 GQLVVYFVNyfiarsGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLATQAL 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 293 DSIKNNIEEEEKEVGsagpvicRMLSYPPTrrALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDrLAIWLASVTAF 372
Cdd:PRK10077 248 QEIKHSLDHGRKTGG-------KLLMFGVG--VIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGASTD-IALLQTIIVGV 317
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 767973034 373 TNFIFTLVGVWLVEKVGRRKLtfgslagttvaLIILALGFVLSA 416
Cdd:PRK10077 318 INLTFTVLAIMTVDKFGRKPL-----------QIIGALGMAIGM 350
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
89-410 4.59e-47

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 166.66  E-value: 4.59e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  89 ALGGFLFGYDTGVVSGAM------------LLLKRQLSLDALW-------QELLVSSTVGAAAVSALAGGALNGVFGRRA 149
Cdd:cd17361    3 ALGGLIFGYDIGISGGVTsmdpflekffpsVYEKKKGASENNYckyddqlLQLFTSSLYLAGLVASLLASYVTRKWGRKP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 150 AILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGA 229
Cdd:cd17361   83 SMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLINYG 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 230 FSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPrwliqkgqtqkarrilsqmrgnqtideeydsiknnieeeekevgsa 309
Cdd:cd17361  163 TSKIKPNGWRLSLGLAAVPALILLLGSLFLPETP---------------------------------------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 310 gpvicrmlSYPPtrraLIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDrLAIWLASVTAFTNFIFTLVGVWLVEKVG 389
Cdd:cd17361  197 --------NSPQ----LVIAILIPFFQQLTGINVIMFYAPVLFQTLGFGSD-ASLISAVITGAVNVVSTLVSIYLVDRFG 263
                        330       340
                 ....*....|....*....|.
gi 767973034 390 RRKLTFGSLAGTTVALIILAL 410
Cdd:cd17361  264 RRFLLLEGGVQMLASQVAIGI 284
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
84-419 7.93e-43

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 156.62  E-value: 7.93e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  84 VAVFSALGG-FLFGYDTGVVSGAMLLLKRqlSLDALWQE------------LLVSSTVGAAAVSALAG----GALNGVFG 146
Cdd:cd17432    1 ATLAAAFGSsFQYGYNLSVVNSPTPYIQN--FYNETWTErygtpleestltLLWSLTVSIFPLGGLFGsllvGPLVIRLG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 147 RRAAiLLASALFTAGSAVLAA----ANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFF 222
Cdd:cd17432   79 RKGT-LLLNNIFAIVAAILMGlskiAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 223 ASVVdGAFSYL-QKDGWRYMLGLAAVPAVIQFFGFLFLPESPRW-LIQKGQTQKARRILSQMRGNQTIDEEYDSIKNNIE 300
Cdd:cd17432  158 GQVL-GLRELLgNEEGWPLLLALTGVPALLQLLTLPFFPESPRYlLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQR 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 301 EEekevGSAGPV-ICRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAiWLASVTAFTNFIFTL 379
Cdd:cd17432  237 AE----KGVGTVsVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQ-YVTVGTGACEVLATI 311
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 767973034 380 VGVWLVEKVGRRKLTFGSLAGTTVALIILALGFVLSAQVS 419
Cdd:cd17432  312 TCVLVIERLGRRPLLIGGFGLMAVWCAVLTVALSLQNTVS 351
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
85-415 1.98e-39

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 145.71  E-value: 1.98e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  85 AVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAV 164
Cdd:cd17435    3 SVTAAVSGLLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 165 LAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQkDGWRYMLGL 244
Cdd:cd17435   83 LVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFANVS-NGWKYMFGL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 245 AAVPAVIQFFGFLFLPESPRWLIqkgqtqkarrilsqMRGNQtideeydsiknnieeeekevgsagpvicrmlsypptRR 324
Cdd:cd17435  162 VIPLAALQAIAMYFLPPSPRFLV--------------MKDNM------------------------------------RA 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 325 ALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRklTFGSLAGTTVA 404
Cdd:cd17435  192 RLLIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSK--TFLCIGSSVMA 269
                        330
                 ....*....|.
gi 767973034 405 LIILALGFVLS 415
Cdd:cd17435  270 VSLVTMGLWLS 280
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
85-414 7.53e-37

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 138.78  E-value: 7.53e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  85 AVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAV 164
Cdd:cd17436    3 ATVSLLGGLTFGYELGIISGALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 165 LAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQkDGWRYMLGL 244
Cdd:cd17436   83 LTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVL-TGWRYMFGL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 245 AAVPAVIQFFGFLFLPESPRWLIQKGQtqkarrilsqmrgnqtideeydsiknnieeeekevgsagpvicrmlsyppTRR 324
Cdd:cd17436  162 AIIPAAIQFASILLLPKKPEVLNIKDN--------------------------------------------------MRR 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 325 ALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIwLASV-TAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTV 403
Cdd:cd17436  192 RTLVGLGLVLFQQFTGQPNVLCYASTIFRSVGFQSNSSAV-LASVgLGVVKVIATLLAMLFADRAGRRSLLIAGCSVMAV 270
                        330
                 ....*....|.
gi 767973034 404 ALIILALGFVL 414
Cdd:cd17436  271 SVSGIGLWITL 281
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
82-413 4.26e-33

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 129.23  E-value: 4.26e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  82 YVVAVFSALGGFLFGYDTGVVSGAMLLLKR----QLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASAL 157
Cdd:cd17433    1 FLATFAAVLGPLSFGFVLGYSSPAIPSLQRiadpALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 158 FTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSylqkdg 237
Cdd:cd17433   81 FIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLD------ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 238 WRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTIDEEYDSIKNNIEEEEKEVGSAGpvicrML 317
Cdd:cd17433  155 WRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPDQGWEWECIGIEQSFHLEEQSFSLA-----LL 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 318 SYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAiwlASVTAFTNFIFTLVGVWLVEKVGRRKLTfgS 397
Cdd:cd17433  230 KQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKDSSVA---SVIVAAIQVLFTAVAALIMDRAGRKVLL--V 304
                        330
                 ....*....|....*.
gi 767973034 398 LAGTTVALIILALGFV 413
Cdd:cd17433  305 LSGVVMVFSTAAFGWL 320
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
77-416 6.94e-28

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 113.53  E-value: 6.94e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  77 TPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASA 156
Cdd:COG2814    4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 157 LFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFsyLQKD 236
Cdd:COG2814   84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL--ADLF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 237 GWRYMLGLAAVPAVIQFF-GFLFLPESPRwliqkgqtQKARRILSQMRgnqtideeydsiknnieeeekevgsagpvicR 315
Cdd:COG2814  162 GWRWVFLVNAVLALLALLlLLRLLPESRP--------AARARLRGSLR-------------------------------E 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 316 MLSYPPTRRALIVGCGLQMfqqlsGINTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTF 395
Cdd:COG2814  203 LLRRPRLLLLLLLAFLLGF-----GFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL 277
                        330       340
                 ....*....|....*....|.
gi 767973034 396 GSLAGTTVALIILALGFVLSA 416
Cdd:COG2814  278 IGLLLLALGLLLLALAGSLWL 298
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
82-267 1.10e-26

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 108.74  E-value: 1.10e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  82 YVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAG 161
Cdd:COG0477   13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 162 SAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQkdGWRYM 241
Cdd:COG0477   93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL--GWRWI 170
                        170       180
                 ....*....|....*....|....*.
gi 767973034 242 LGLAAVPAVIQFFGFLFLPESPRWLI 267
Cdd:COG0477  171 FLINAPLGLLALVLRLRLPESRGLLL 196
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
84-418 4.99e-25

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 106.46  E-value: 4.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  84 VAVFSA-LGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGA----LNGVFGRRAAILLASALF 158
Cdd:cd17434    2 LAVFSAvLGNFSFGYALVYTSPVIPALEQGDDPRLHLNVHQISWFGSVFTLGAAAGGLsamfLNDRLGRKLSIMFSAVPS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 159 TAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITggqfFASVVDGAFSYLQKdgW 238
Cdd:cd17434   82 ALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAV----FGSLALYALGLLLP--W 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 239 RYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRG-NQTIDEEYDSIKNNIEEEEKEVGsagpviCRML 317
Cdd:cd17434  156 RWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLRGpNTDYMTEFEQIKDNIRKQSSRLS------WAEL 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 318 SYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGV----EDDrlaiwlASVTAFTNFIFTLVGVWLVEKVGRRKL 393
Cdd:cd17434  230 KTPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAVilepKYD------AALVGAVRLLSVAIAASLMDKAGRKIL 303
                        330       340
                 ....*....|....*....|....*
gi 767973034 394 TFGSLAGTTVALIILALGFVLSAQV 418
Cdd:cd17434  304 LFTSAFLMFAANLSMGLIPLIAAML 328
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
89-416 4.39e-23

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 100.19  E-value: 4.39e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  89 ALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAA 168
Cdd:cd06174    2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 169 NNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKDGWRYMLGLAAVP 248
Cdd:cd06174   82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAAL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 249 AVIQFFGFLFLPESPRWLIQKG-QTQKARRILSQMRgnqtideeydsiknnieeeekevgsagpvicRMLSYPPTrRALI 327
Cdd:cd06174  162 ALLAAILLLLVVPDPPESARAKnEEASSKSVLKLLK-------------------------------RVLKNPGL-WLLL 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 328 VGCGLQMFqqlsGINTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKV-GRRKLTFGSLAGTTVALI 406
Cdd:cd06174  210 LAIFLVNL----AYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLA 285
                        330
                 ....*....|
gi 767973034 407 ILALGFVLSA 416
Cdd:cd06174  286 LLLLAPSLLL 295
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
85-418 4.82e-21

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 93.82  E-value: 4.82e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  85 AVFSALGGFLFGYDTGVVSGAMLLLKRQLS--LDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGS 162
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 163 AVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYL--QKDGWRY 240
Cdd:cd17316   81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLlsGDWGWRI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 241 MLGLAAVPAVIQFFgflflpesprwliqkgqtqkarrilsqmrgnqtideeydsiknnieeeekevgsagpvicrmlsyp 320
Cdd:cd17316  161 LFLIGALPALLALL------------------------------------------------------------------ 174
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 321 pTRRALIVGCGLQMFQQLS--GINTIM-YYSATILQMSGVEddrlAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGS 397
Cdd:cd17316  175 -LRRRTLLLILLWFFISFGyyGLTTFLpTYLQTVLGLSPAT----SSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIG 249
                        330       340
                 ....*....|....*....|.
gi 767973034 398 LAGTTVALIILALGFVLSAQV 418
Cdd:cd17316  250 LILSGILALPLFYLLSGSPTL 270
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
87-430 8.59e-21

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 93.52  E-value: 8.59e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  87 FSALGGFLF-GYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVL 165
Cdd:cd17371    2 WAAFLGWALdGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLC 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 166 AAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDG-AFSYLQKD-GWRYMLG 243
Cdd:cd17371   82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAAlLFPLLPPEiAWRVLFL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 244 LAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQmrgnqtideeydsiknnieeeekevgsagpvicRMLSYPPTR 323
Cdd:cd17371  162 LGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSL---------------------------------RELFSPPLL 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 324 RALIVGCGLQMFQQLS--GINTIMyysATIL-QMSGVEDDRLAIWLAsVTAFTNFIFTLVGVWLVEKVGRRKltfgslag 400
Cdd:cd17371  209 RTTLLASLLATGALGGyyGITTWL---PSYLtGERGLSFEGSAGYLV-VTILGGFLGYLAGGFLADRIGRRN-------- 276
                        330       340       350
                 ....*....|....*....|....*....|
gi 767973034 401 ttvaliILALGFVLSAQVSPRITFKPIAPS 430
Cdd:cd17371  277 ------NFALFALGSAISILLYFFLPLSPT 300
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
80-415 3.66e-18

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 85.87  E-value: 3.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034   80 FVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFT 159
Cdd:TIGR00895  14 YQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFS 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  160 AGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTIN----TLFITGGQFFASVVDGAFsylqk 235
Cdd:TIGR00895  94 VFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMfcgyPIGAAVGGFLAGWLIPVF----- 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  236 dGWRYMLGLAAV-PAVIQFFGFLFLPESPRWLIQKGqTQKARRILSQmrgnqtIDEEYDSIKNNIEEEEKEVGSAGPVIC 314
Cdd:TIGR00895 169 -GWRSLFYVGGIaPLLLLLLLMRFLPESIDFLVSKR-PETVRRIVNA------IAPQMQAEAQSALPEQKSTQGTKRSVF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  315 RMLsYPPTRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAIWLAsVTAFTNFIFTLVGVWLVEKVGRRKLT 394
Cdd:TIGR00895 241 KAL-FQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGA-LFNFGGVIGSIIFGWLADRLGPRVTA 318
                         330       340
                  ....*....|....*....|.
gi 767973034  395 FGSLAGttvALIILALGFVLS 415
Cdd:TIGR00895 319 LLLLLG---AVFAVLVGSTLF 336
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
133-415 7.78e-18

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 85.84  E-value: 7.78e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  133 VSALAGGALNGVFGRRAaILLASALFTAGSAVLAA-ANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTI 211
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKK-VLLLSTLVTAVSGVLTAfSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTL 220
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  212 NTLFITGGQFFASVVdgafSYLQKDgWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRIL---SQMRGNQTI 288
Cdd:TIGR00898 221 IQVFFSLGLVLLPLV----AYFIPD-WRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILqriAKINGKKLP 295
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  289 DEEYDSIKNNIEEEEKEVGSagpvICRMLSYPPTRRALIvgcglqMFQQLSGINTIMYYSaTILQMSGVEDDrlAIWLAS 368
Cdd:TIGR00898 296 AEVLSLSLEKDLSSSKKQYS----FLDLFRTPNLRKTTL------CLMMLWFTTAFSYYG-LVLDLGNLGGN--IYLDLF 362
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 767973034  369 VTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVAliILALGFVLS 415
Cdd:TIGR00898 363 ISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVA--LLLLLFVPV 407
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
82-251 3.86e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 76.45  E-value: 3.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  82 YVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAG 161
Cdd:COG2271    9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 162 SAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFsyLQKDGWRYM 241
Cdd:COG2271   89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL--LAAFGWRAA 166
                        170
                 ....*....|
gi 767973034 242 LGLAAVPAVI 251
Cdd:COG2271  167 FLILGLPGLL 176
MFS_1 pfam07690
Major Facilitator Superfamily;
89-418 1.07e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.15  E-value: 1.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034   89 ALGGFLFGYDTGVVSGAM-LLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAA 167
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  168 ANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQkdGWRYMLGLAAV 247
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF--GWRAAFLILAI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  248 PAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMrgnqtideeydsiknnieeeekevgsagpvicRMLSYPPTRRALI 327
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW--------------------------------KALLRDPVLWLLL 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  328 VGCGLQMfqqlsGINTIMYYSATILQMSGVeDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALII 407
Cdd:pfam07690 208 ALLLFGF-----AFFGLLTYLPLYQEVLGL-SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
                         330
                  ....*....|.
gi 767973034  408 LALGFVLSAQV 418
Cdd:pfam07690 282 LLLLSLTLSSL 292
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
89-416 1.15e-13

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 72.20  E-value: 1.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  89 ALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAA 168
Cdd:cd17324    5 ALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 169 NNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSylQKDGWRYMLGLAAVP 248
Cdd:cd17324   85 PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLG--QLLGWRAAFLAIAVL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 249 AVIQFFGFLF-LPESPrwliqkGQTQKARRILSQMRgnqtideeydsiknnieeeekevgsagpvicRMLSYPPTRRALI 327
Cdd:cd17324  163 ALLAALLLWRlLPSLP------PKKPGSLGLLSSLL-------------------------------LLLRNPRLRLAYL 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 328 VGCGLqmfqqLSGINTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALII 407
Cdd:cd17324  206 ITFLL-----FGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLL 280

                 ....*....
gi 767973034 408 LALGFVLSA 416
Cdd:cd17324  281 TLLGPSPLL 289
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
82-410 2.55e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 71.07  E-value: 2.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  82 YVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAG 161
Cdd:COG2223    4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 162 SAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGrlvTINTLFITGGQFFASVVDGAFSYL-QKDGWRY 240
Cdd:COG2223   84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRG---LALGLAAGGGNLGAAVAAFLAPLLiAAFGWRN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 241 MLGLAAVP-AVIQFFGFLFLPESPrwliqKGQTQKARRILSQMRgnqtideeydsiknnieeeekevgsagpvicRMLSY 319
Cdd:COG2223  161 AFLILGILlLVVAVLAWLFLRDPP-----AGAAAAAKASLRDQL-------------------------------EALRD 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 320 PPTRRALIVGCGlqMFQQLSGINTIMyysATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLA 399
Cdd:COG2223  205 PRFWLLSLLYFG--TFGSFIGFSSWL---PPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFA 279
                        330
                 ....*....|.
gi 767973034 400 GTTVALIILAL 410
Cdd:COG2223  280 LMALGLLLLAL 290
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
96-251 3.24e-13

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 70.69  E-value: 3.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  96 GYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLL 175
Cdd:cd17365   12 GFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLA 91
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767973034 176 AGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVdgAFSYLQKDGWRYMLGLAAVPAVI 251
Cdd:cd17365   92 LLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFL--AAALIPAFGWRSVFLLGGVPPLI 165
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
89-254 6.19e-13

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 69.89  E-value: 6.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  89 ALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAA 168
Cdd:cd17321    2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 169 NNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFsyLQKDGWRYMLGLAAVP 248
Cdd:cd17321   82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLL--LELFGWRWIFLINVPI 159

                 ....*.
gi 767973034 249 AVIQFF 254
Cdd:cd17321  160 GLVALL 165
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
109-420 3.97e-12

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 67.59  E-value: 3.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 109 LKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIA 188
Cdd:COG2807   44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVG 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 189 SMTVPVYIAEVSPPNlRGRLVTINTLFITGGQFFASVVdgAFSYLQKDGWRYMLGLAAVPAVIQFFGFL-FLPESPRWLI 267
Cdd:COG2807  124 NVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGL--TVPLAAALGWRGALAVWALLALLALLLWLpLLRRRPAAAA 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 268 QKGQTQKARRILSqmrgnqtideeydsiknnieeeekevgsagpvicrmlsyppTRRALIVGCGlqMFQQLSGINTIMYY 347
Cdd:COG2807  201 AAPAAASLRSLWR-----------------------------------------SPLAWLLTLF--FGLQSLLYYAVVAW 237
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767973034 348 SATILQMSGVeDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTfgsLAGTTVALIILALGFVLSAQVSP 420
Cdd:COG2807  238 LPPILRDAGL-SAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPL---LLLLGLLGLAGLLGLLLAPGSLP 306
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
79-411 2.14e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 65.26  E-value: 2.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  79 AFVYVVAVFsalggFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALF 158
Cdd:COG0738    9 ALIAIYLLF-----FLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 159 TAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFiTGGQFFASVVDGAFSYLQKD-G 237
Cdd:COG0738   84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFF-SLGALLGPLLGGLLILLGLSlS 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 238 WRYMLGLAAVPAVIQFFGFLFLPeSPRWLIQKGQTQKARRILSQMRGNqtideeydsiknnieeeekevgsagpvicrml 317
Cdd:COG0738  163 WHLPYLILAVLLLLLALLFLRSK-LPEIEEEEEEAAGSAASLKSLLKN-------------------------------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 318 sypptrRALIVGCGLQMFQQLSGInTIMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGS 397
Cdd:COG0738  210 ------PRLLLGGLAIFLYVGAEG-AIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLS 282
                        330
                 ....*....|....
gi 767973034 398 LAGTTVALIILALG 411
Cdd:COG0738  283 ALLAAVGLLLALLA 296
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
81-251 2.55e-11

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 64.90  E-value: 2.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  81 VYVVAVFSALGGFLFgyDTGVVSGAMLLLKRQLsLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTA 160
Cdd:cd17473  199 VLPIYFLAFLAMLLF--YVIPIQLPFLLQERGG-GSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 161 GSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKDGWRY 240
Cdd:cd17473  276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGA 355
                        170
                 ....*....|.
gi 767973034 241 MLGLAAVPAVI 251
Cdd:cd17473  356 FLILGVLALVL 366
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
124-411 2.78e-10

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 61.93  E-value: 2.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 124 VSSTVGAAAVSALA------GGALNGVF----GRRAAILLASALFTAGSAVLAAANNKET--------LLAGRLVVGLGI 185
Cdd:cd17367   36 TVALLSTAAVFAVGflmrpiGGWLFGRLadriGRRAALTLSVSLMAAGSLVIAVTPTYATigiwapiiLLLARLLQGLSV 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 186 GIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKD------GWRYMLGLAAVPAVIQFFGFLFL 259
Cdd:cd17367  116 GGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLGEdqmaawGWRIPFLLGGVLAVVVLWLRRGL 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 260 PESPRWLIQKGQTQKARRILSQMRGNqtideeydsiknnieeeekevgsagpvicrmlsypptRRALIVGCGLqmfqqlS 339
Cdd:cd17367  196 EETESFEAIAESNEASAGTLRELRRH-------------------------------------PRELLLVVGL------T 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 340 GINTIMYYSATI-----LQMSGVEDDRLAIWlasVTAFTNFIFTL---VGVWLVEKVGRRK--LTFGSLAGTTVALIILA 409
Cdd:cd17367  233 AGGTLAFYTWTTylqkfLVNTAGFSKGDATW---ITTAALLVFMLlqpLGGRLSDRIGRRPllLFFGIGGTLATVPLLSA 309

                 ..
gi 767973034 410 LG 411
Cdd:cd17367  310 LD 311
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
81-264 2.37e-09

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 58.74  E-value: 2.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  81 VYVVAVFSALGgflfgydTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTA 160
Cdd:cd17474    4 VFFATLLAVLG-------VSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGI 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 161 GSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAfsyLQKDGWRY 240
Cdd:cd17474   77 GGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL---LAAISWRY 153
                        170       180
                 ....*....|....*....|....
gi 767973034 241 MLGLAAVPAVIQFFGFLFLPESPR 264
Cdd:cd17474  154 PFFLLAALIPVAFLAILFLLPEPK 177
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
132-261 7.52e-09

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 57.20  E-value: 7.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 132 AVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTI 211
Cdd:cd17323   48 GLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGV 127
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767973034 212 NTLFITGGQFFASVVDGAFSylQKDGWRYMLG-LAAVPAVIQFFGFLFLPE 261
Cdd:cd17323  128 YSLGPLLGPALGPIIGGFIT--QSLGWRWIFWfLAIISGFCLILIFLFLPI 176
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
83-220 8.74e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 56.91  E-value: 8.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  83 VVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGS 162
Cdd:COG2814  208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767973034 163 AVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQ 220
Cdd:COG2814  288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
130-278 1.09e-08

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 57.25  E-value: 1.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 130 AAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVyIAEVSPPNLRGRLV 209
Cdd:cd06179   44 AQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAV-ASELVPNKYRGLVQ 122
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767973034 210 TINTLFITGGQFFASVVDGAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFL--PESPRWLIQKGQTQKARRI 278
Cdd:cd06179  123 GVVNLVASPGSALGPLIAGALVEANAAGWRWIFYINAIFNALALILLFFFyhPPPRPQLHGSSTRQKLKRL 193
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
133-282 1.18e-08

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 57.29  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  133 VSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTIN 212
Cdd:TIGR01299 217 VGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWL 296
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  213 TLFITGGQFFASVVDGAF-----------SYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQ 281
Cdd:TIGR01299 297 CMFWMIGGIYAAAMAWAIiphygwsfqmgSAYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKL 376

                  .
gi 767973034  282 M 282
Cdd:TIGR01299 377 I 377
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
78-260 1.80e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.03  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  78 PAFVYVVAVFSALGGFLFGYD---TGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRR--AAIL 152
Cdd:COG2271  173 PGLLLALLRFWLLALAYFLVYfalYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLA 252
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 153 LASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFsy 232
Cdd:COG2271  253 IGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL-- 330
                        170       180
                 ....*....|....*....|....*...
gi 767973034 233 LQKDGWRYMLGLAAVPAVIQFFGFLFLP 260
Cdd:COG2271  331 LDATGYQAAFLLLAALALLAALLALLLL 358
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
133-282 2.88e-08

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 55.69  E-value: 2.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 133 VSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTIN 212
Cdd:cd17440   49 VGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWL 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 213 TLFITGGQFFASVVDGAF-----------SYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQ 281
Cdd:cd17440  129 CMFWMIGGIYASAMAWAIiphygwsfsmgSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQ 208

                 .
gi 767973034 282 M 282
Cdd:cd17440  209 I 209
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
133-282 2.90e-08

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 55.70  E-value: 2.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 133 VSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTIN 212
Cdd:cd17438   49 AGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWL 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 213 TLFITGGQFFASVVdgAFSYLQKDGWRYMLG-------------LAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRIL 279
Cdd:cd17438  129 CMFWMIGGLYASAM--AWSIIPHYGWGFSMGtnyhfhswrvfviICALPCIASIIALKFMPESPRFLLEMGKHDEAWMIL 206

                 ...
gi 767973034 280 SQM 282
Cdd:cd17438  207 KNI 209
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
133-282 3.12e-08

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 55.57  E-value: 3.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 133 VSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTIN 212
Cdd:cd17363   49 VGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWL 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 213 TLFITGGQFFASVVdgAFSYLQKDGWRYMLGLA-------------AVPAVIQFFGFLFLPESPRWLIQKGQTQKARRIL 279
Cdd:cd17363  129 CMFWMIGGLYASAM--AWAIIPHYGWGFSMGTAyqfhswrvfvivcALPSVASVVALTFMPESPRFLLEVGKHDEAWMIL 206

                 ...
gi 767973034 280 SQM 282
Cdd:cd17363  207 KQV 209
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
89-410 3.22e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 55.27  E-value: 3.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  89 ALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAA 168
Cdd:cd17325    2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 169 NNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQkdGWRYMLGLAAVP 248
Cdd:cd17325   82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL--GYRAPFLVCAAL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 249 AVIQFFGFLFLPESPRwliqkgqTQKARRILSQMRGNQTIdeeydsiknnieeeekevgsagpvicRMLSYPPTRRALIV 328
Cdd:cd17325  160 ALLALVLALLLLPEPR-------PPPNKRAVSAARLRSGL--------------------------RLLLRDRRLLALFL 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 329 GCGLQMFQQLSGINTIMYYSATILQMSGVEddrlAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALIIL 408
Cdd:cd17325  207 AIFVLAFAFGALEPFLPLYAAELGGLSPAQ----IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282

                 ..
gi 767973034 409 AL 410
Cdd:cd17325  283 PL 284
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
84-259 3.91e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 54.93  E-value: 3.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  84 VAVFSALGGFLFGydtGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSA 163
Cdd:cd06173  213 LLLALALFALLGG---ALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 164 VLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFsyLQKDGWRYMLG 243
Cdd:cd06173  290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLL--ADALGLSAVFL 367
                        170
                 ....*....|....*.
gi 767973034 244 LAAVPAVIQFFGFLFL 259
Cdd:cd06173  368 LAGALLLLAALLLLLL 383
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
119-260 4.15e-08

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 54.85  E-value: 4.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 119 WQELLVSSTVGAA-AVSALAGGALNGVFGRRAaILLASALFTAGSAVLAA-ANNKETLLAGRLVVGLGIGIASMTVPVYi 196
Cdd:cd17372   34 WQVALITSVVFAGmMIGSYLWGIVSDKYGRRK-GLIISALWTFYAGFLSAfAPNYMWLIILRCLVGLGLGGGPQLASWY- 111
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767973034 197 AEVSPPNLRGRLVTINTLFITGGQFFASVVdgAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLP 260
Cdd:cd17372  112 LEFLPAKSRGTWMVLFSVFWTVGTIFEASL--AWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTP 173
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
90-258 4.86e-08

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 54.49  E-value: 4.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  90 LGGFLFGYDTGVVSGAMLLLKRQL-SLDAL-WqelLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAA 167
Cdd:cd17502    3 LALFLAALDQTIVATALPTIVAEFgGLSLVsW---VGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 168 ANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTintlfITGGQF-FASVV----DGAFSylQKDGWR--- 239
Cdd:cd17502   80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQG-----YIGAVFgIASVAgpliGGAFT--DHLSWRwcf 152
                        170       180
                 ....*....|....*....|....*..
gi 767973034 240 --------YMLGLAAVPAVIQFFGFLF 258
Cdd:cd17502  153 yinlpiggLALALLRTILLSSIFGFLF 179
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
80-259 4.98e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 54.89  E-value: 4.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  80 FVYVVAVFSALGGFLFGydtGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFT 159
Cdd:cd17325  200 RLLALFLAIFVLAFAFG---ALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 160 AGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSylQKDGWR 239
Cdd:cd17325  277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY--DAFGFA 354
                        170       180
                 ....*....|....*....|
gi 767973034 240 YMLGLAAVPAVIQFFGFLFL 259
Cdd:cd17325  355 TPFLAAAALLLLAAVLFLLL 374
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
145-410 5.71e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 54.91  E-value: 5.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 145 FGRRAAILLASALFTAGSAVL--AAANNKETLLAGRLVVG---LGIGIASMTVPVY--IAEVSP-PNLRGRLVTINTLFI 216
Cdd:COG2211   77 WGRRRPWILIGAIPLALSFVLlfTAPDLSPTGKLIYALVTyllLGLAYTLVNIPYSalGAELTPdYEERTRLSSWRFAFA 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 217 TGGQFFASVV----DGAFSYLQKDGWRYMLGLAAVPAVI-QFFGFLFLPESPRwliQKGQTQKARRILSQMRGNqtidee 291
Cdd:COG2211  157 GLGGLLASVLppplVAAFGGDAALGYRLTALIFAVLGLLaFLLTFFGTKERPV---PEEEKVSLKESLKALLKN------ 227
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 292 ydsiknnieeeekevgsagpvicrmlsyPPTRRALIVGCGLQMFQQLSGInTIMYYSATILQMSgvedDRLAIWLASVTA 371
Cdd:COG2211  228 ----------------------------RPFLLLLLAYLLFFLALALVAA-LLLYYFKYVLGLS----AALVGLLLALYF 274
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 767973034 372 FTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALIILAL 410
Cdd:COG2211  275 LAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF 313
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
131-260 8.08e-08

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 53.74  E-value: 8.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 131 AAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVT 210
Cdd:cd17317   38 VLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGI 117
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 767973034 211 INTLFITGGQFFASVVdgafSYLQKDgWRYMLGLAAVPAVIQFFGFLFLP 260
Cdd:cd17317  118 LFGLFWALGYMLLALL----AYLIRD-WRWLQLAISLPGLLFLLLLWWLP 162
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
122-410 1.06e-07

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 53.86  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 122 LLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSP 201
Cdd:cd17333   35 VIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 202 PNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKDGWRYM-LGLAAVPAVIQFFGFLFlPESPRWLIQKGQTQKARRILS 280
Cdd:cd17333  115 ESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLiIGLIYLLLAILILLTLF-PELPSARNPQQSVGAFSASAS 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 281 QMRGNqtideeydsiknnieeeekevgsagpvicrmlsypptrRALIVGCGLQMFQQLSGInTIMYYSATILQMSGVEDD 360
Cdd:cd17333  194 RLLRN--------------------------------------PSIILGALALFLYVGAET-AFSSWVPSYLVEKKHVSD 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 767973034 361 RLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALIILAL 410
Cdd:cd17333  235 GLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLL 284
PRK03893 PRK03893
putative sialic acid transporter; Provisional
85-265 2.88e-07

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 52.78  E-value: 2.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  85 AVFSALGGFLF-GYDTGVVSGAMLLLKRQLSLDALWQELLVSstvgAAAVSALAGGALNGV----FGRRAAILLASALFT 159
Cdd:PRK03893  21 AFSAAWLGYLLdGFDFVLITLVLTEVQGEFGLTTVQAASLIS----AAFISRWFGGLLLGAmgdrYGRRLAMVISIVLFS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 160 AGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRlvtINTLFITGGQFFASVVDGAFSYLQKD-GW 238
Cdd:PRK03893  97 VGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNK---ASGFLISGFSIGAVVAAQVYSLVVPVwGW 173
                        170       180
                 ....*....|....*....|....*..
gi 767973034 239 RYMLGLAAVPAVIQFFGFLFLPESPRW 265
Cdd:PRK03893 174 RALFFIGILPIIFALWLRKNLPEAEDW 200
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
105-283 3.19e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 52.19  E-value: 3.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 105 AMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLG 184
Cdd:cd17320   21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 185 IGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQkdGWRYMLGLAAVPAVIQFFG-FLFLPESp 263
Cdd:cd17320  101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF--GWRAIFVFLALLGLLLLLLvLLFLPET- 177
                        170       180
                 ....*....|....*....|
gi 767973034 264 rwLIQKGQTQKARRILSQMR 283
Cdd:cd17320  178 --LPEEKRKPLLSSLLRAYK 195
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
122-263 3.45e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.21  E-value: 3.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 122 LLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSP 201
Cdd:cd17489   35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIP 114
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767973034 202 PNLRGRLVTINTLFITGGQFFASVVDGAFSylQKDGWRYMLGLAAVPAVIQFFGFLFLPESP 263
Cdd:cd17489  115 PSRRGEGIGYYGLATTLAMALGPALGLFLY--QHLGFAVLFIVAAVLALLALLLVFLVKDPP 174
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
77-257 3.45e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 52.19  E-value: 3.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  77 TPAFVYVVAVFSALGGFLFGydtGVVSGAMLLLKRQLSLDALWQELLVSS-TVGAAAVSALAGGALNGVFGRRAAILLAS 155
Cdd:cd17474  196 RGRGLLTFLVSAFLYFFLYF---AFLTYLPFLLELLYGISPIIIGLLFAGwSVLLALGSLFVGRLLKKRFGARRILVIGL 272
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 156 ALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQK 235
Cdd:cd17474  273 LLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG 352
                        170       180
                 ....*....|....*....|..
gi 767973034 236 DGWRYMLGLAAVPAVIQFFGFL 257
Cdd:cd17474  353 LSAPFLVGAAIALAAAVLLALL 374
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
78-259 5.92e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.44  E-value: 5.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  78 PAFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSStvGAAAVSALAGGALNGVFGRRAAILLASAL 157
Cdd:cd17489  189 RRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYA--IALLLSRPFSGKLSDRKGPKTVIIPGLLL 266
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 158 FTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSylQKDG 237
Cdd:cd17489  267 LALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVA--ELFG 344
                        170       180
                 ....*....|....*....|..
gi 767973034 238 WRYMLGLAAVPAVIQFFGFLFL 259
Cdd:cd17489  345 YRAMFLLAAVVVLLALVLYIFL 366
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
89-251 1.42e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 50.27  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  89 ALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAA 168
Cdd:cd17504    2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 169 NNKETLLAGRLVVGLGIGIasmtVPVYIA---EVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSylQKDGWRYMLGLA 245
Cdd:cd17504   82 PNLPVLIAGRALQGIGGAV----FPLAFAlvrEEFPPERVPVAQGILSATFGIGAGIGLPLGGWIV--QHLGWRWIFWTA 155

                 ....*.
gi 767973034 246 AVPAVI 251
Cdd:cd17504  156 APVAVL 161
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
119-266 1.67e-06

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 49.81  E-value: 1.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 119 WQELLVSSTV--GAAAVSALAGGaLNGVFGRRAAILLaSALFTAGSAVLAA-ANNKETLLAGRLVVGLGIGIASMTVPVY 195
Cdd:cd17441   34 WQVALLTSVVfiGMMLSSSLWGN-ISDQYGRKTGLKI-SVLWTLYYGILSAfAPIYSWILVLRGLVGFGIGGVPQSVTLY 111
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767973034 196 iAEVSPPNLRGRLVTINTLFITGGQFFASVVdgAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWL 266
Cdd:cd17441  112 -AEFLPMKSRAKCILLIEVFWALGTVFEVLL--AVFVMPTLGWRWLLILSALPLLIFAVLCFWLPESARYW 179
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
86-254 2.73e-06

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 49.20  E-value: 2.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  86 VFSALGGFLFGYDTGVVSGAMLLLKR-----QLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTA 160
Cdd:cd17364    2 IIAGMGFFTDAYDLFSISLVTKILGRlyyggKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMII 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 161 GSAVLAAANNKE------TLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVV-------- 226
Cdd:cd17364   82 GTILSALSPGSTplgvmgWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVtlilsaif 161
                        170       180       190
                 ....*....|....*....|....*....|..
gi 767973034 227 ---DGAFSYLQKDG-WRYMLGLAAVPAVIQFF 254
Cdd:cd17364  162 ehpLPAGTYHHADLvWRIVLGLGAIPALSVLY 193
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
135-284 3.52e-06

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 49.19  E-value: 3.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 135 ALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIAsmtVPVYIA---EVSPPNLRGRLVTI 211
Cdd:PRK11551  67 ALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGA---LPNLIAltsEAVGPRLRGTAVSL 143
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767973034 212 NTLFITGGQFFASVVdGAFSYLQkDGWR---YMLGLAavPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRG 284
Cdd:PRK11551 144 MYCGVPFGGALASVI-GVLAAGD-AAWRhifYVGGVG--PLLLVPLLMRWLPESRAFAQAAGAGKQRAPVLRALFG 215
PRK12307 PRK12307
MFS transporter;
85-269 3.96e-06

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 48.77  E-value: 3.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  85 AVFSALGGFLF-GYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSA 163
Cdd:PRK12307  19 ALFSAWLGYVFdGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTG 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 164 VLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLvtinTLFITGGQFFASVVDGAF--SYLQKDGWRYM 241
Cdd:PRK12307  99 LSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKA----SAFLVSGFGIGNIIAAYFmpSFAEAYGWRAA 174
                        170       180
                 ....*....|....*....|....*...
gi 767973034 242 LGLAAVPAVIQFFGFLFLPESPRWLIQK 269
Cdd:PRK12307 175 FFVGLLPVLLVIYIRARAPESKEWEEAK 202
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
133-282 4.19e-06

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 48.87  E-value: 4.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 133 VSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTIN 212
Cdd:cd17439   49 VGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWL 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 213 TLFITGGQFFASVVDGAF-----------SYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQ 281
Cdd:cd17439  129 CMFWMIGGIYASAMAWAIiphygwsfqmgSAYQFHSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQ 208

                 .
gi 767973034 282 M 282
Cdd:cd17439  209 V 209
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
89-260 7.37e-06

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 47.96  E-value: 7.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  89 ALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAA 168
Cdd:cd17503    2 LLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 169 NNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFS-YLqkdGWRYMLgLAAV 247
Cdd:cd17503   82 PNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTdNL---SWRWIF-YINL 157
                        170
                 ....*....|...
gi 767973034 248 PAVIqfFGFLFLP 260
Cdd:cd17503  158 PIGI--LALLLAP 168
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
83-257 9.27e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.81  E-value: 9.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  83 VVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGS 162
Cdd:cd06174  205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGL 284
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 163 AVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVdGAFSYLQKDGWRYML 242
Cdd:cd06174  285 ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLL-AGFLLAATFGLTGAF 363
                        170
                 ....*....|....*
gi 767973034 243 GLAAVPAVIQFFGFL 257
Cdd:cd06174  364 LVLAVLLLLAAILLL 378
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
83-285 1.13e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 47.59  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  83 VVAVFSALGGFLFGydtgvvSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGS 162
Cdd:COG2211  235 LAYLLFFLALALVA------ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 163 AVLAAA--NNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPP-------NLRGRLVTINTLFITGGQFFASVVDG----A 229
Cdd:COG2211  309 LLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYdewktgrRREGLYFGIFTFAIKLGQALAGALAGlllaL 388
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767973034 230 FSYLQKDG------WRYMLGLAAVPAVIQFFGFLFLpesPRWLIQKGQTQKARRILSQMRGN 285
Cdd:COG2211  389 FGYVAGAAqspsalTGIRLLFFLLPAVLLLLAALLL---LFYPLTRERHAEIRAELAARRAA 447
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
116-264 1.82e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.80  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 116 DALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVY 195
Cdd:cd17473   33 SELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATAL 112
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767973034 196 IAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLqkdGWRYMLGLAAVPAVIQFFGFLFLPESPR 264
Cdd:cd17473  113 IGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI---GWRAPFLVYLLALPVLILVLLFLPEPAR 178
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
90-256 2.15e-05

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 46.60  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034   90 LGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAAN 169
Cdd:TIGR00711   9 LGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  170 NKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFSYLQkdGWRYM------LG 243
Cdd:TIGR00711  89 NLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENY--HWRWIflinvpIG 166
                         170
                  ....*....|...
gi 767973034  244 LAAVPAVIQFFGF 256
Cdd:TIGR00711 167 IIVVVVAFFILPR 179
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
83-257 2.78e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 46.00  E-value: 2.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  83 VVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGS 162
Cdd:cd17324  199 RLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALL 278
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 163 AVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNlRGRLVTINTLFITGGQFFASVVDGAFsyLQKDGWRYML 242
Cdd:cd17324  279 LLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLV--LDHGGWAGVG 355
                        170
                 ....*....|....*
gi 767973034 243 GLAAVPAVIQFFGFL 257
Cdd:cd17324  356 WVGAALLLLALLLAL 370
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
92-259 3.12e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 46.02  E-value: 3.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  92 GFLFGY-DTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANN 170
Cdd:cd17319   11 AYVINYlDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 171 KETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRlvtINTLFITgGQFFASVVDGAFS-YLQKD-GWRYMLGLAAVP 248
Cdd:cd17319   91 LTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGR---ATGLFNS-GAPLGAAIGPPLSgWLLLLfGWRWAFIIEGLL 166
                        170
                 ....*....|.
gi 767973034 249 AVIQFFGFLFL 259
Cdd:cd17319  167 GLLLAVLWWFY 177
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
139-424 1.47e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 43.75  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 139 GALNGVFGRRAAILLASALFTAGSAVLAA-ANNKETLLAGRLVVGLGigiASMTV--PVYIAEVSPPNLRGRLVTINTLF 215
Cdd:cd17490   52 GILSDRIGKRKLFIIIGLLFTVLASLIMIlFPSPWGLLIARFLSGIA---AATWVsfTVLYASYFPPDEAAKAMGLINLV 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 216 ITGGQFFASVVDGAFSylQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRwlIQKGQTQKARRILSQMRgnqtideeydsi 295
Cdd:cd17490  129 NNLGQLIAFLIGGLIA--EHFGMRAPFLLAALAGVLGFILSLFIKEERR--EKKPVLTELKELLSVLK------------ 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 296 knnieeeekevgsagpvicrmlsypptRRALIVGCGLQMFQQLSGINTIMYYSATILQMSGVEDDRLAiWLASVTAFTNF 375
Cdd:cd17490  193 ---------------------------DKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLG-LLSIIYLLPNA 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767973034 376 IFTLVGVWLVEKV-GRRKLTFGSLAGTTVALIIL----ALGFVLSAQVSPRITF 424
Cdd:cd17490  245 LASLLSGTLFYKKlGERNTIIIGFLLLGAYCFLIpfapNLTLLYLLQALNGFGT 298
MFS_1 pfam07690
Major Facilitator Superfamily;
79-224 2.10e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.18  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034   79 AFVYVVAVFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLAS--- 155
Cdd:pfam07690 196 ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALlll 275
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767973034  156 ALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFAS 224
Cdd:pfam07690 276 ILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
128-221 2.58e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.93  E-value: 2.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 128 VGAAAVSALAGGALNGVfGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGR 207
Cdd:cd17477   42 LGILLGSPLVPRLIRRV-GHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGR 120
                         90
                 ....*....|....
gi 767973034 208 LVTINTLFITGGQF 221
Cdd:cd17477  121 VLGLYSTVLGLGFA 134
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
88-263 3.20e-04

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 42.75  E-value: 3.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  88 SALGGFLFGYDTGVVSGAMLLLKRQL--SLDALWQELLVSSTVGAAAVSALAGGALNGVF----GRRAAILLASALFTAG 161
Cdd:cd17368    4 ATSGNALEFFDFGVYGFFAVYIGRLFfpSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYadriGRKPAMTLTLAIMALG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 162 SAVLAAANNKET--------LLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGrlvtINTLFITGGQFFASVVDGAFSY- 232
Cdd:cd17368   84 TLLIALAPTYATigiaapllVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRG----FYTSWQSASQQVAIVAGALVGYl 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767973034 233 ---------LQKDGWRYMLGLAAVPAVIQFFGFLFLPESP 263
Cdd:cd17368  160 lsltltaeaLAEWGWRIPFFIGLLIIPLGLWLRRSLEETE 199
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
109-259 8.51e-04

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 41.41  E-value: 8.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 109 LKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSaVLAAANNKETLLAGRLVVGLGIGIA 188
Cdd:cd17339   25 IRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGI-LLRSLGGIALLFLGTALAGAGIAVG 103
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767973034 189 SMTVPVYIAEVSPPNLrGRLVTINTLFITGGQFFASVVDGAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFL 259
Cdd:cd17339  104 NVLLPSLIKRDFPRRV-GLMTGLYTTSMNLGAALASGLSVPLAQALGGGWRGALAIWALPALLALLIWLPQ 173
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
145-264 1.10e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 41.07  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 145 FGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFAS 224
Cdd:cd17328   61 YNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGY 140
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767973034 225 VVDGAFSYLQKdGWRYMLGLAAVPAVI-QFFGFLFLPESPR 264
Cdd:cd17328  141 VVGGLVAQATG-GWRWAFRVTGVLGVLlAILLLLFVREPPR 180
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
93-257 1.10e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.99  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  93 FLFGydTGVVSGAMLLLKRQ-LSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNK 171
Cdd:cd17370  210 ALFA--LGNFSFAFLILRAQeLGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSL 287
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 172 ETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGAFsyLQKDGWRYMLGLAAVPAVI 251
Cdd:cd17370  288 WLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYL--WDLISPSAAFLFSAVLALI 365

                 ....*.
gi 767973034 252 QFFGFL 257
Cdd:cd17370  366 ALLLLL 371
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
86-264 1.30e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.02  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  86 VFSALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVL 165
Cdd:COG2223  209 LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 166 AAA-NNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVdGAFSYLQKDGWRYMLGL 244
Cdd:COG2223  289 ALAlGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLL-FGALLDATGSYTAAFLV 367
                        170       180
                 ....*....|....*....|
gi 767973034 245 AAVPAVIQFFGFLFLPESPR 264
Cdd:COG2223  368 FAVLALVALVLTLLLYRRPR 387
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
105-259 1.58e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 40.67  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 105 AMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLG 184
Cdd:cd17329   22 MAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFG 101
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767973034 185 IGIASMTVPVYIAEVSPPNLRGRLVTINTLFITggqffASVVDGAF--SYLQKDGWRYMLGLAAVPAVIQFFGFLFL 259
Cdd:cd17329  102 GGLFEPASEAMIADVTTPENRTRAFSLLYWAIN-----LGVAIGPLlgGLLLLYSFRLLFLAAAVLFLLAALVLLFL 173
cynX PRK09705
putative cyanate transporter; Provisional
122-257 1.95e-03

putative cyanate transporter; Provisional


Pssm-ID: 236614 [Multi-domain]  Cd Length: 393  Bit Score: 40.18  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 122 LLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSP 201
Cdd:PRK09705  48 LLTALPVVTMGGLALAGSWLHQHVSERRSVAISLLLIAVGALMRELYPQSALLLSSALLGGVGIGIIQAVMPSVIKRRFQ 127
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767973034 202 PNLRGRLVTINTLFITGGQFFASVVDGAFSYLQKdgWRYMLGLAAVPAVIQFFGFL 257
Cdd:PRK09705 128 QRTPLVMGLWSAALMGGGGLGAAITPWLVQHSET--WYQTLAWWALPAVVALFAWW 181
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
145-264 2.47e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.89  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 145 FGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLG-IGIASMTvpvYIAEVSPPNLRGRLVTINTLFItGGQFFA 223
Cdd:cd17472   59 IGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGaISSVVMA---LLADLTREENRTKAMALIGASI-GIAFAI 134
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767973034 224 SVVDGAFSYlQKDGWRYMLGLAAVPAVIQFF-GFLFLPESPR 264
Cdd:cd17472  135 SMVLGPLLA-AHLGVSGLFLITAILSLVSLLiLLFFVPDPPK 175
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
108-251 2.88e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.51  E-value: 2.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 108 LLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKE--TLLAGRLVVGLGI 185
Cdd:cd17316  203 YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSptLLLLLLFILSFFV 282
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767973034 186 GIASMTVPVYIAEVSPPNLRGRLVTI-----NTLFITGGQFFASVVDGAFSYLqkdGWRYMLGLAAVPAVI 251
Cdd:cd17316  283 GGVWGALYAYLAELFPTEVRATGVGLsynlgRLGGGGAPPLIALLLASTGGTG---VPALILALLAIVALI 350
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
145-242 3.10e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.52  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 145 FGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFAS 224
Cdd:cd17329  263 FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGP 342
                         90
                 ....*....|....*...
gi 767973034 225 VVDGAFSYLQKDGWRYML 242
Cdd:cd17329  343 LVGGLLLDLLGPGLPWLI 360
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
63-199 3.77e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 39.65  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034   63 DLERAARRQFQQDETPAFVY----VVAVFSalggflfGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVG--------A 130
Cdd:pfam06609  18 DRLRAKALATSAAELPDGYYrsprIIASFA-------AFSLNVCATYFVLQASASALPNILQDIGQSENQGlfstlwtmG 90
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767973034  131 AAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTvPVYIAEV 199
Cdd:pfam06609  91 QAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAGAS-PLFIGEL 158
PRK10504 PRK10504
putative transporter; Provisional
89-194 4.18e-03

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 39.33  E-value: 4.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034  89 ALGGFLFGYDTGVVSGAMLLLKRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAA 168
Cdd:PRK10504  16 AFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALS 95
                         90       100
                 ....*....|....*....|....*.
gi 767973034 169 NNKETLLAGRLVVGLGigiASMTVPV 194
Cdd:PRK10504  96 GTLNELLLARVLQGVG---GAMMVPV 118
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
139-261 4.48e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 39.18  E-value: 4.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 139 GALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVGLGIGIASMTVPVyIAEVSPPNLRGR-LVTINTLFIT 217
Cdd:cd17389   85 GAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAI-VADVTSPKKRSKgMALIGVAFSL 163
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767973034 218 G-------GQFFASVV-DGAFSYLQKDGWrymlgLAAVPAVIQ-FFGFLFLPE 261
Cdd:cd17389  164 GfiigpmiGAYFASFTrSLGEVFFSMPAL-----FALVLALADlLFIFFFLPE 211
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
130-260 6.76e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 38.71  E-value: 6.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 130 AAAVSALAGGALNGVFGRRA---AILLASALFTAGSAVLAAANNKE--TLLAGRLVVGLGIGIASMTVPVYIAEVSPPNL 204
Cdd:cd17504  225 PGALVMLIAGPLAGRLIARVgprRVLLIGLVISAVGLLLLALLHSSlwALVVALLLIGIGLGLAFASLPNIVVESVPPDR 304
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767973034 205 RGRLVTINTLFITGGQFFASVVDGAF-----------SYLQKDGWRYMLGLAAVPAVIQFFGFLFLP 260
Cdd:cd17504  305 TGIATGMNTVLRTIGSAIGPAIAGAIlttytvsitsgGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
139-262 7.69e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 38.39  E-value: 7.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973034 139 GALNGVFGRRAAILLASALFTAGSAVLAAANNKETLLAGRLVVglGIGIASMTVP-VYIAEVSPPNLR-GRLVTINTLFi 216
Cdd:cd17388   59 GALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIA--GITGATGAVAaAYIADVTPPEQRaRNFGLLGAAF- 135
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767973034 217 tGGQFFASVVDGAFsyLQKDGWRYMLGLAAVPAVIQF-FGFLFLPES 262
Cdd:cd17388  136 -GLGFIAGPALGGL--LGEISPRAPFLVAAGLNGLNFlLGLFVLPES 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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