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Conserved domains on  [gi|767970485|ref|XP_011541252|]
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matrix metalloproteinase-27 isoform X4 [Homo sapiens]

Protein Classification

M10A family metallopeptidase( domain architecture ID 11995186)

M10A family metallopeptidase similar to matrix metalloproteinases with a C-terminal hemopexin repeat-containing domain that may be endopeptidases that degrade various components of the extracellular matrix

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 9-156 1.89e-82

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


:

Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 249.46  E-value: 1.89e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485    9 RIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRcPRYFDGPLGVLGHAFPPGPGLGGDT 88
Cdd:pfam00413  10 RILNYTPDLPRAEVRRAIRRAFKVWSEVTPLTFTEVSTGEADIMIGFGRGDHGD-GYPFDGPGGVLAHAFFPGPGLGGDI 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767970485   89 HFDEDENWTKDGA---GFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYG 156
Cdd:pfam00413  89 HFDDDETWTVGSDpphGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSPLDSKKFRLSQDDIKGIQQLYG 159
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 171-360 1.07e-64

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 205.24  E-value: 1.07e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485 171 PHACDPdLTFDAITTFRREVMFFKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYENP-RDKILVFKDENFWMIRGY 249
Cdd:cd00094    1 PDACDP-LSFDAVTTLRGELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERPdTGKIYFFKGDKYWVYTGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485 250 AVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAFQY-KG 328
Cdd:cd00094   80 NLEPGYPKPISDLGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIETDFPGVPDKVDAAFRWlDG 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767970485 329 FFFFSRGSKQFEYDIKTK--NITRIMRTNT-WFQC 360
Cdd:cd00094  160 YYYFFKGDQYWRFDPRSKevRVGYPLKISSdWLGC 194
 
Name Accession Description Interval E-value
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 9-156 1.89e-82

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 249.46  E-value: 1.89e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485    9 RIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRcPRYFDGPLGVLGHAFPPGPGLGGDT 88
Cdd:pfam00413  10 RILNYTPDLPRAEVRRAIRRAFKVWSEVTPLTFTEVSTGEADIMIGFGRGDHGD-GYPFDGPGGVLAHAFFPGPGLGGDI 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767970485   89 HFDEDENWTKDGA---GFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYG 156
Cdd:pfam00413  89 HFDDDETWTVGSDpphGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSPLDSKKFRLSQDDIKGIQQLYG 159
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 171-360 1.07e-64

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 205.24  E-value: 1.07e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485 171 PHACDPdLTFDAITTFRREVMFFKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYENP-RDKILVFKDENFWMIRGY 249
Cdd:cd00094    1 PDACDP-LSFDAVTTLRGELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERPdTGKIYFFKGDKYWVYTGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485 250 AVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAFQY-KG 328
Cdd:cd00094   80 NLEPGYPKPISDLGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIETDFPGVPDKVDAAFRWlDG 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767970485 329 FFFFSRGSKQFEYDIKTK--NITRIMRTNT-WFQC 360
Cdd:cd00094  160 YYYFFKGDQYWRFDPRSKevRVGYPLKISSdWLGC 194
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 9-156 2.35e-63

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 200.51  E-value: 2.35e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485   9 RIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGI-ADIMIAFRTRVHGrCPRYFDGPLGVLGHAFPPGpGLGGD 87
Cdd:cd04278   10 RILNYPPDLPRDDVRRAIARAFRVWSDVTPLTFREVTSGQeADIRISFARGNHG-DGYPFDGPGGTLAHAFFPG-GIGGD 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767970485  88 THFDEDENWTKDGA--GFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPrKYPLSQDDINGIQSIYG 156
Cdd:cd04278   88 IHFDDDEQWTLGSDsgGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVP-KFKLSQDDIRGIQALYG 157
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 21-156 1.37e-25

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 100.89  E-value: 1.37e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485    21 AVDEAIQEGLEVWSKVTPLKFTKISKGiADIMIAFRTRVHGRCpryfdgplgvLGHAFPPGpglgGDTHFDeDENWTkDG 100
Cdd:smart00235  22 EEREAIAKALAEWSDVTCIRFVERTGT-ADIYISFGSGDSGCT----------LSHAGRPG----GDQHLS-LGNGC-IN 84

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767970485   101 AGfnlflVAAHEFGHALGLSHS---NDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYG 156
Cdd:smart00235  85 TG-----VAAHELGHALGLYHEqsrSDRDNYMYINYTNIDTRNFDLSEDDSLGIPYDYG 138
COG5549 COG5549
Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; ...
 19-155 1.22e-08

Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444292 [Multi-domain]  Cd Length: 234  Bit Score: 55.08  E-value: 1.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485  19 RAAVDEAIQEglevWSKVTPLKFTKiSKGIADIMIAFRTRvhgrcpryfdgPLGvlghaFPPGPGLGG-----DTHFDED 93
Cdd:COG5549  103 VAAVLQAIAE----WNAYLPLEVVE-NPENADIIIVRSNP-----------PLT-----ASPNPETGArsaetTYEFYDT 161

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767970485  94 EN--------WTKDGAGFNLFLVAA-HEFGHALGL-SHSNDQTALMFPNYVSLDPrkyPLSQDDINGIQSIY 155
Cdd:COG5549  162 GNilshrftiLLSPNQTGKYLLATArHELGHALGIwGHSPSPTDAMYFSQVRNPP---PISPRDINTLKRIY 230
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 271-316 5.64e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 43.00  E-value: 5.64e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 767970485   271 IDAAVCDKTTrKTYFFVGIWCWRFDEmtQTMDKGFPQRVVKHFPGI 316
Cdd:smart00120   1 IDAAFELRDG-KTYFFKGDKYWRFDP--KRVDPGYPKLISSFFPGL 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 224-265 7.26e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 39.86  E-value: 7.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767970485  224 LQAAYENPRDKILVFKDENFWMIRGYAVLPDYPKSIHTL-GFP 265
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGYPKLISDFpGLP 43
 
Name Accession Description Interval E-value
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 9-156 1.89e-82

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 249.46  E-value: 1.89e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485    9 RIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRcPRYFDGPLGVLGHAFPPGPGLGGDT 88
Cdd:pfam00413  10 RILNYTPDLPRAEVRRAIRRAFKVWSEVTPLTFTEVSTGEADIMIGFGRGDHGD-GYPFDGPGGVLAHAFFPGPGLGGDI 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767970485   89 HFDEDENWTKDGA---GFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYG 156
Cdd:pfam00413  89 HFDDDETWTVGSDpphGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSPLDSKKFRLSQDDIKGIQQLYG 159
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 171-360 1.07e-64

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 205.24  E-value: 1.07e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485 171 PHACDPdLTFDAITTFRREVMFFKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYENP-RDKILVFKDENFWMIRGY 249
Cdd:cd00094    1 PDACDP-LSFDAVTTLRGELYFFKGRYFWRLSPGKPPGSPFLISSFWPSLPSPVDAAFERPdTGKIYFFKGDKYWVYTGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485 250 AVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAFQY-KG 328
Cdd:cd00094   80 NLEPGYPKPISDLGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIETDFPGVPDKVDAAFRWlDG 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767970485 329 FFFFSRGSKQFEYDIKTK--NITRIMRTNT-WFQC 360
Cdd:cd00094  160 YYYFFKGDQYWRFDPRSKevRVGYPLKISSdWLGC 194
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 9-156 2.35e-63

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 200.51  E-value: 2.35e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485   9 RIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGI-ADIMIAFRTRVHGrCPRYFDGPLGVLGHAFPPGpGLGGD 87
Cdd:cd04278   10 RILNYPPDLPRDDVRRAIARAFRVWSDVTPLTFREVTSGQeADIRISFARGNHG-DGYPFDGPGGTLAHAFFPG-GIGGD 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767970485  88 THFDEDENWTKDGA--GFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPrKYPLSQDDINGIQSIYG 156
Cdd:cd04278   88 IHFDDDEQWTLGSDsgGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVP-KFKLSQDDIRGIQALYG 157
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 21-156 1.37e-25

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 100.89  E-value: 1.37e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485    21 AVDEAIQEGLEVWSKVTPLKFTKISKGiADIMIAFRTRVHGRCpryfdgplgvLGHAFPPGpglgGDTHFDeDENWTkDG 100
Cdd:smart00235  22 EEREAIAKALAEWSDVTCIRFVERTGT-ADIYISFGSGDSGCT----------LSHAGRPG----GDQHLS-LGNGC-IN 84

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767970485   101 AGfnlflVAAHEFGHALGLSHS---NDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYG 156
Cdd:smart00235  85 TG-----VAAHELGHALGLYHEqsrSDRDNYMYINYTNIDTRNFDLSEDDSLGIPYDYG 138
ZnMc_MMP_like_1 cd04279
Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and ...
 25-156 1.84e-16

Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239806 [Multi-domain]  Cd Length: 156  Bit Score: 75.96  E-value: 1.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485  25 AIQEGLEVWSKVTPLKFTKI--SKGIADIMIAFRTRVH-----GRCPRYFDGPLGVLGHAFPPgpglggdtHFDEDENWT 97
Cdd:cd04279   25 AVKQAAAEWENVGPLKFVYNpeEDNDADIVIFFDRPPPvggagGGLARAGFPLISDGNRKLFN--------RTDINLGPG 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485  98 KDGAGFNLFLVAAHEFGHALGLSHSNDQ-TALMFPNYVSLDPRKYPLSQDDINGIQSIYG 156
Cdd:cd04279   97 QPRGAENLQAIALHELGHALGLWHHSDRpEDAMYPSQGQGPDGNPTLSARDVATLKRLYG 156
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
 24-156 3.86e-14

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 70.52  E-value: 3.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485  24 EAIQEGLEVWSKVTPLKFTKISKG-IADIMIAFrtrvhgrcprYFDGPLGVLGHAFPPGPG----LGGDTHFDEDENWTK 98
Cdd:cd04277   37 AAARDALEAWEDVADIDFVEVSDNsGADIRFGN----------SSDPDGNTAGYAYYPGSGsgtaYGGDIWFNSSYDTNS 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485  99 DGAGFNLFLVAAHEFGHALGLSHSND----------------QTALM----FPNYVSLDPRKYP--LSQDDINGIQSIYG 156
Cdd:cd04277  107 DSPGSYGYQTIIHEIGHALGLEHPGDynggdpvpptyaldsrEYTVMsynsGYGNGASAGGGYPqtPMLLDIAALQYLYG 186
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 16-155 2.75e-13

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 67.55  E-value: 2.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485  16 DMARAAVDEAIQEGLEVWSKVTPLKFTKISKGI--ADIMIaFRTRVhgrcpryfDGPLGVLGHAFPPG--PGLGGDTHFD 91
Cdd:cd00203   17 ENLSAQIQSLILIAMQIWRDYLNIRFVLVGVEIdkADIAI-LVTRQ--------DFDGGTGGWAYLGRvcDSLRGVGVLQ 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485  92 EDENWTKDGAGfnlflVAAHEFGHALGLSHSNDQTA--------------------LMFPNYVS-LDPRKYPLSQDDING 150
Cdd:cd00203   88 DNQSGTKEGAQ-----TIAHELGHALGFYHDHDRKDrddyptiddtlnaedddyysVMSYTKGSfSDGQRKDFSQCDIDQ 162


                 ....*
gi 767970485 151 IQSIY 155
Cdd:cd00203  163 INKLY 167
COG5549 COG5549
Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; ...
 19-155 1.22e-08

Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444292 [Multi-domain]  Cd Length: 234  Bit Score: 55.08  E-value: 1.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485  19 RAAVDEAIQEglevWSKVTPLKFTKiSKGIADIMIAFRTRvhgrcpryfdgPLGvlghaFPPGPGLGG-----DTHFDED 93
Cdd:COG5549  103 VAAVLQAIAE----WNAYLPLEVVE-NPENADIIIVRSNP-----------PLT-----ASPNPETGArsaetTYEFYDT 161

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767970485  94 EN--------WTKDGAGFNLFLVAA-HEFGHALGL-SHSNDQTALMFPNYVSLDPrkyPLSQDDINGIQSIY 155
Cdd:COG5549  162 GNilshrftiLLSPNQTGKYLLATArHELGHALGIwGHSPSPTDAMYFSQVRNPP---PISPRDINTLKRIY 230
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 9-155 1.27e-08

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 54.04  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485   9 RIINYTPDMARAAVDEAIQEglevWSKVTPLKFTKISKGI-ADIMIAFrtrvhGRCPRYFDGPLGVLGHAFPPgpgLGGD 87
Cdd:cd04268    7 YIDDSVPDKLRAAILDAIEA----WNKAFAIGFKNANDVDpADIRYSV-----IRWIPYNDGTWSYGPSQVDP---LTGE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485  88 THFDeDENWTKDGAGFN---LFLVAAHEFGHALGLSHSN----------------DQTALMFPNYVSL-----DPRKYPL 143
Cdd:cd04268   75 ILLA-RVYLYSSFVEYSgarLRNTAEHELGHALGLRHNFaasdrddnvdllaekgDTSSVMDYAPSNFsiqlgDGQKYTI 153

                        170
                 ....*....|..
gi 767970485 144 SQDDINGIQSIY 155
Cdd:cd04268  154 GPYDIAAIKKLY 165
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 271-316 5.64e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 43.00  E-value: 5.64e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 767970485   271 IDAAVCDKTTrKTYFFVGIWCWRFDEmtQTMDKGFPQRVVKHFPGI 316
Cdd:smart00120   1 IDAAFELRDG-KTYFFKGDKYWRFDP--KRVDPGYPKLISSFFPGL 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 224-265 7.26e-05

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 39.86  E-value: 7.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767970485  224 LQAAYENPRDKILVFKDENFWMIRGYAVLPDYPKSIHTL-GFP 265
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGYPKLISDFpGLP 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 224-266 7.62e-05

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 39.92  E-value: 7.62e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767970485   224 LQAAYENPRDKILVFKDENFWMIRGYAVLPDYPKSIHTLgFPG 266
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGYPKLISSF-FPG 42
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 72-156 2.19e-04

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 42.02  E-value: 2.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485  72 GVLGHAFPPGPG-LGGDTHFDEDENWTKDGAgfnlfLVAAHEFGHALGLSH--------SNDQTALMFPNYVSLDPRKYP 142
Cdd:cd04267  104 DILGLAYVGSMCnPYSSVGVVEDTGFTLLTA-----LTMAHELGHNLGAEHdggdelafECDGGGNYIMAPVDSGLNSYR 178

                         90
                 ....*....|....
gi 767970485 143 LSQDDINGIQSIYG 156
Cdd:cd04267  179 FSQCSIGSIREFLD 192
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 180-221 3.47e-04

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 37.99  E-value: 3.47e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767970485   180 FDAITTFRR-EVMFFKGRHLWRIYYDITDVEF-ELIASFWPSLP 221
Cdd:smart00120   1 IDAAFELRDgKTYFFKGDKYWRFDPKRVDPGYpKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 271-316 8.32e-04

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 36.78  E-value: 8.32e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767970485  271 IDAAVCDKTtRKTYFFVGIWCWRFDEmtQTMDKGFPQRvVKHFPGI 316
Cdd:pfam00045   1 IDAAFEDRD-GKTYFFKGRKYWRFDP--QRVEPGYPKL-ISDFPGL 42
ZnMc_MMP_like_3 cd04327
Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal ...
 20-121 4.04e-03

Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239819 [Multi-domain]  Cd Length: 198  Bit Score: 38.13  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970485  20 AAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRvhgrcpryfDGPLGVLG---HAFP---PGPGLGGDTHFDED 93
Cdd:cd04327   19 AFLKDKVRAAAREWLPYANLKFKFVTDADADIRISFTPG---------DGYWSYVGtdaLLIGadaPTMNLGWFTDDTPD 89

                         90       100
                 ....*....|....*....|....*...
gi 767970485  94 ENWTKdgagfnlflVAAHEFGHALGLSH 121
Cdd:cd04327   90 PEFSR---------VVLHEFGHALGFIH 108
COG1913 COG1913
Predicted Zn-dependent protease [General function prediction only];
108-134 4.69e-03

Predicted Zn-dependent protease [General function prediction only];


Pssm-ID: 441517  Cd Length: 175  Bit Score: 37.63  E-value: 4.69e-03
                         10        20
                 ....*....|....*....|....*...
gi 767970485 108 VAAHEFGHALGLSHSNDQTALM-FPNYV 134
Cdd:COG1913  126 EAVHELGHLFGLGHCPNPRCVMhFSNSL 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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