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Conserved domains on  [gi|767967748|ref|XP_011543165|]
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autophagy-related protein 2 homolog A isoform X1 [Homo sapiens]

Protein Classification

VPS13 family protein( domain architecture ID 10330881)

VPS13 family protein similar to intermembrane lipid transfer protein VPS13B that mediates the transfer of lipids between membranes at organelle contact sites

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 1841-1934 1.63e-37

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


:

Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 136.48  E-value: 1.63e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967748  1841 RRGQQPADLREGVAKAYDTVREGILDTAQTICDVASRGHEQKGLTGAVGGVIRQLPPTVVKPLILATEATSSLLGGMRNQ 1920
Cdd:pfam09333    3 LYANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVRNQ 82

                           90
                   ....*....|....
gi 767967748  1921 IVPDAHKDHALKWR 1934
Cdd:pfam09333   83 LDPENRRESEDKYK 96
Chorein_N super family cl14987
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 14-108 8.71e-10

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


The actual alignment was detected with superfamily member pfam12624:

Pssm-ID: 463646  Cd Length: 116  Bit Score: 57.96  E-value: 8.71e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967748    14 ERVCRYLLHHYLGHFFQEhLSLDQLSLDLYKGSVALRDIHLeiwsVNEVLESMESPLELVEGFVGSIEVAVPWAALLTDH 93
Cdd:pfam12624    2 ESLVASLLNRYLGEYVEN-LDPDQLKVGLWSGDVVLENLKL----KKEALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEP 76

                           90
                   ....*....|....*
gi 767967748    94 CTVRVSGLQLTLQPR 108
Cdd:pfam12624   77 VVIEIEDVYLLAVPK 91
 
Name Accession Description Interval E-value
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 1841-1934 1.63e-37

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 136.48  E-value: 1.63e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967748  1841 RRGQQPADLREGVAKAYDTVREGILDTAQTICDVASRGHEQKGLTGAVGGVIRQLPPTVVKPLILATEATSSLLGGMRNQ 1920
Cdd:pfam09333    3 LYANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVRNQ 82

                           90
                   ....*....|....
gi 767967748  1921 IVPDAHKDHALKWR 1934
Cdd:pfam09333   83 LDPENRRESEDKYK 96
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 14-108 8.71e-10

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 57.96  E-value: 8.71e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967748    14 ERVCRYLLHHYLGHFFQEhLSLDQLSLDLYKGSVALRDIHLeiwsVNEVLESMESPLELVEGFVGSIEVAVPWAALLTDH 93
Cdd:pfam12624    2 ESLVASLLNRYLGEYVEN-LDPDQLKVGLWSGDVVLENLKL----KKEALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEP 76

                           90
                   ....*....|....*
gi 767967748    94 CTVRVSGLQLTLQPR 108
Cdd:pfam12624   77 VVIEIEDVYLLAVPK 91
 
Name Accession Description Interval E-value
ATG_C pfam09333
Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral ...
 1841-1934 1.63e-37

Autophagy-related protein C terminal domain; ATG2 (also known as Apg2) is a peripheral membrane protein. It functions in both cytoplasm-to-vacuole targeting and in autophagy.


Pssm-ID: 462761 [Multi-domain]  Cd Length: 96  Bit Score: 136.48  E-value: 1.63e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967748  1841 RRGQQPADLREGVAKAYDTVREGILDTAQTICDVASRGHEQKGLTGAVGGVIRQLPPTVVKPLILATEATSSLLGGMRNQ 1920
Cdd:pfam09333    3 LYANQPEDVREGLQQAYSSLERGLGSAADAIIAVPGEVYESKGAGGAAKAVLRAVPVAVLRPAIGATEAVSKTLLGVRNQ 82

                           90
                   ....*....|....
gi 767967748  1921 IVPDAHKDHALKWR 1934
Cdd:pfam09333   83 LDPENRRESEDKYK 96
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
 14-108 8.71e-10

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 57.96  E-value: 8.71e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767967748    14 ERVCRYLLHHYLGHFFQEhLSLDQLSLDLYKGSVALRDIHLeiwsVNEVLESMESPLELVEGFVGSIEVAVPWAALLTDH 93
Cdd:pfam12624    2 ESLVASLLNRYLGEYVEN-LDPDQLKVGLWSGDVVLENLKL----KKEALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEP 76

                           90
                   ....*....|....*
gi 767967748    94 CTVRVSGLQLTLQPR 108
Cdd:pfam12624   77 VVIEIEDVYLLAVPK 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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