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Conserved domains on  [gi|767956099|ref|XP_011516459|]
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endosome-associated-trafficking regulator 1 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 228-400 2.96e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 2.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099   228 DRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEakMIKEEsdyhdlesvVQQVEQNLELMTKRAVK 307
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQ--ILRER---------LANLERQLEELEAQLEE 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099   308 AENHVVKLKQEISLLQAQVSNFQRENEALRcGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNlvAEILK 387
Cdd:TIGR02168  328 LESKLDELAEELAELEEKLEELKEELESLE-AELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN--NEIER 404

                          170
                   ....*....|...
gi 767956099   388 SIDRISEVKDEEE 400
Cdd:TIGR02168  405 LEARLERLEDRRE 417
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 228-400 2.96e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 2.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099   228 DRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEakMIKEEsdyhdlesvVQQVEQNLELMTKRAVK 307
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQ--ILRER---------LANLERQLEELEAQLEE 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099   308 AENHVVKLKQEISLLQAQVSNFQRENEALRcGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNlvAEILK 387
Cdd:TIGR02168  328 LESKLDELAEELAELEEKLEELKEELESLE-AELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN--NEIER 404

                          170
                   ....*....|...
gi 767956099   388 SIDRISEVKDEEE 400
Cdd:TIGR02168  405 LEARLERLEDRRE 417
AAA_13 pfam13166
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 231-328 5.95e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.


Pssm-ID: 463796 [Multi-domain]  Cd Length: 712  Bit Score: 38.89  E-value: 5.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099  231 LRTLQISYDALKDE---NSKLRRKLNEVQSFSEAQTEMVRTLER-----------------KLEAKMIKE-ESDYHDLES 289
Cdd:pfam13166 337 LDGLRRALEAKRKDpfkSIELDSVDAKIESINDLVASINELIAKhneitdnfeeeknkakkKLRLHLVEEfKSEIDEYKD 416

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 767956099  290 VVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSN 328
Cdd:pfam13166 417 KYAGLEKAINSLEKEIKNLEAEIKKLREEIKELEAQLRD 455
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 257-389 6.15e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.59  E-value: 6.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099 257 SFSEAQTEMVRTLERKLEA--KMIKE-ESDYHDLESVVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSNFQREN 333
Cdd:COG4942   13 LAAAAQADAAAEAEAELEQlqQEIAElEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEI 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767956099 334 EALRcgqgASLTvvKQNADVALQNLRVVMNSAQASIKQLVSGAETLNLV--AEILKSI 389
Cdd:COG4942   93 AELR----AELE--AQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVrrLQYLKYL 144
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 228-400 2.96e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 2.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099   228 DRHLRTLQISYDALKDENSKLRRKLNEVQSFSEAQTEMVRTLERKLEakMIKEEsdyhdlesvVQQVEQNLELMTKRAVK 307
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQ--ILRER---------LANLERQLEELEAQLEE 327

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099   308 AENHVVKLKQEISLLQAQVSNFQRENEALRcGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETLNlvAEILK 387
Cdd:TIGR02168  328 LESKLDELAEELAELEEKLEELKEELESLE-AELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN--NEIER 404

                          170
                   ....*....|...
gi 767956099   388 SIDRISEVKDEEE 400
Cdd:TIGR02168  405 LEARLERLEDRRE 417
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 239-353 1.11e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099   239 DALKDE----NSKLRRKLNEVQSFSEAQTEMVRTLERkLEAKMIKEESDYHDLESVVQQVEQNLELMTKRAVKAENHVVK 314
Cdd:TIGR02169  395 EKLKREinelKRELDRLQEELQRLSEELADLNAAIAG-IEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYD 473

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 767956099   315 LKQEISLLQAQVSNFQRENEALRCGQGASLTVVKQNADV 353
Cdd:TIGR02169  474 LKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAV 512
AAA_13 pfam13166
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 231-328 5.95e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.


Pssm-ID: 463796 [Multi-domain]  Cd Length: 712  Bit Score: 38.89  E-value: 5.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099  231 LRTLQISYDALKDE---NSKLRRKLNEVQSFSEAQTEMVRTLER-----------------KLEAKMIKE-ESDYHDLES 289
Cdd:pfam13166 337 LDGLRRALEAKRKDpfkSIELDSVDAKIESINDLVASINELIAKhneitdnfeeeknkakkKLRLHLVEEfKSEIDEYKD 416

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 767956099  290 VVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSN 328
Cdd:pfam13166 417 KYAGLEKAINSLEKEIKNLEAEIKKLREEIKELEAQLRD 455
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 257-389 6.15e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.59  E-value: 6.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099 257 SFSEAQTEMVRTLERKLEA--KMIKE-ESDYHDLESVVQQVEQNLELMTKRAVKAENHVVKLKQEISLLQAQVSNFQREN 333
Cdd:COG4942   13 LAAAAQADAAAEAEAELEQlqQEIAElEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEI 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767956099 334 EALRcgqgASLTvvKQNADVALQNLRVVMNSAQASIKQLVSGAETLNLV--AEILKSI 389
Cdd:COG4942   93 AELR----AELE--AQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVrrLQYLKYL 144
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
225-400 6.51e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 38.34  E-value: 6.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099 225 SLGDRHLRTLQISYDALKDENSKLRRKLNEvqsfseAQTEMvRTLERKLEAKmiKEEsdyhdlesvVQQVEQNLELMTKR 304
Cdd:COG4372   27 AALSEQLRKALFELDKLQEELEQLREELEQ------AREEL-EQLEEELEQA--RSE---------LEQLEEELEELNEQ 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099 305 AVKAENHVVKLKQEISLLQAQVSNFQRENEALRcGQGASLTVVKQNADVALQNLRVVMNSAQASIKQLVSGAETL-NLVA 383
Cdd:COG4372   89 LQAAQAELAQAQEELESLQEEAEELQEELEELQ-KERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLqEELA 167

                        170
                 ....*....|....*..
gi 767956099 384 EILKSIDRISEVKDEEE 400
Cdd:COG4372  168 ALEQELQALSEAEAEQA 184
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
287-401 8.92e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 38.46  E-value: 8.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767956099 287 LESVVQQ-VEQNLELMTKRAVKA----ENHVVKLKQEISLLQAQVSNFQRENEALRCGQGASLTVVK-QNADVALQNLRV 360
Cdd:COG3206  154 ANALAEAyLEQNLELRREEARKAleflEEQLPELRKELEEAEAALEEFRQKNGLVDLSEEAKLLLQQlSELESQLAEARA 233

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767956099 361 VMNSAQASIKQLVSGAETLNLVAEILKSIDRISEVKDEEED 401
Cdd:COG3206  234 ELAEAEARLAALRAQLGSGPDALPELLQSPVIQQLRAQLAE 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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