NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767946880|ref|XP_011514123|]
View 

ankyrin repeat and SOCS box protein 15 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-293 4.14e-34

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.84  E-value: 4.14e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880   2 IIPKGMDTNDDPDEDHLTSYDIQLSIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEK 81
Cdd:COG0666    7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  82 GWFPLHEAVvqpiqqileivldavKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDG 161
Cdd:COG0666   87 GNTLLHAAA---------------RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDN 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 162 FGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGH 241
Cdd:COG0666  152 DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGN 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767946880 242 YLALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 293
Cdd:COG0666  232 LEIVKLLLEAGADlNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 485-540 6.10e-31

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03731:

Pssm-ID: 470605  Cd Length: 56  Bit Score: 114.16  E-value: 6.10e-31
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767946880 485 ENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKL 540
Cdd:cd03731    1 ENPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQELKL 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
265-360 7.85e-12

Ankyrin repeats (3 copies);


:

Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 7.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  265 IHSAADGQNAQCLELLIENGFDVNTLladhisqsyDDERKTALYFGVSNNDVHCTEVLLA-AGADPNLDPLNCLLVAVRA 343
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ---------DKNGRTALHLAAKNGHLEIVKLLLEhADVNLKDNGRTALHYAARS 71

                          90
                  ....*....|....*..
gi 767946880  344 NNYEIVRLLLSHGANVN 360
Cdd:pfam12796  72 GHLEIVKLLLEKGADIN 88
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-293 4.14e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.84  E-value: 4.14e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880   2 IIPKGMDTNDDPDEDHLTSYDIQLSIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEK 81
Cdd:COG0666    7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  82 GWFPLHEAVvqpiqqileivldavKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDG 161
Cdd:COG0666   87 GNTLLHAAA---------------RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDN 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 162 FGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGH 241
Cdd:COG0666  152 DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGN 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767946880 242 YLALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 293
Cdd:COG0666  232 LEIVKLLLEAGADlNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 485-540 6.10e-31

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 114.16  E-value: 6.10e-31
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767946880 485 ENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKL 540
Cdd:cd03731    1 ENPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQELKL 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 115-397 2.40e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 81.25  E-value: 2.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 115 TLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHcdVLEHlihkggdvlalad 194
Cdd:PHA03100  20 YIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKY--NLTD------------- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 195 dgasvlfeaagggNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE--GHYLALKYLIPVTSK-NAIRKSGLTPIHSAADG 271
Cdd:PHA03100  85 -------------VKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANvNIKNSDGENLLHLYLES 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 272 --QNAQCLELLIENGFDVNT------LLADHISQSYDDER-KTALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLV 339
Cdd:PHA03100 152 nkIDLKILKLLIDKGVDINAknrvnyLLSYGVPINIKDVYgFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYgdtPLHI 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767946880 340 AVRANNYEIVRLLLSHGANVN---CYFMHVNDTRFPSVIQYAL-NDEVMLRLLLNNGYQVEM 397
Cdd:PHA03100 232 AILNNNKEIFKLLLNNGPSIKtiiETLLYFKDKDLNTITKIKMlKKSIMYMFLLDPGFYKNR 293
Ank_2 pfam12796
Ankyrin repeats (3 copies);
200-289 1.68e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 1.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  200 LFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNaIRKSGLTPIHSAADGQNAQCLEL 279
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN-LKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|
gi 767946880  280 LIENGFDVNT 289
Cdd:pfam12796  80 LLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
265-360 7.85e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 7.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  265 IHSAADGQNAQCLELLIENGFDVNTLladhisqsyDDERKTALYFGVSNNDVHCTEVLLA-AGADPNLDPLNCLLVAVRA 343
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ---------DKNGRTALHLAAKNGHLEIVKLLLEhADVNLKDNGRTALHYAARS 71

                          90
                  ....*....|....*..
gi 767946880  344 NNYEIVRLLLSHGANVN 360
Cdd:pfam12796  72 GHLEIVKLLLEKGADIN 88
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 486-527 1.13e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 59.49  E-value: 1.13e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767946880  486 NPCSLKHLCRLKIRRLMGLQKLCQpasVEKLPLPPAIQRYIL 527
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 488-529 1.09e-08

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 50.87  E-value: 1.09e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767946880   488 CSLKHLCRLKIRRLMGLqklcqpasVEKLPLPPAIQRYILFK 529
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--------IDKLPLPPRLKDYLLYY 34
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 196-360 2.61e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.00  E-value: 2.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  196 GASVLFEAAGGGNP-DCISLLLEYGGSGNVpnraGHLPIHRAA---YEGHYLALKYLIPVTSK-------NAIRKS---- 260
Cdd:TIGR00870  52 GRSALFVAAIENENlELTELLLNLSCRGAV----GDTLLHAISleyVDAVEAILLHLLAAFRKsgplelaNDQYTSeftp 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  261 GLTPIHSAADGQNAQCLELLIENGFDVN---TLLADHISQsyddeRKTALYFGVSnndvhctevllaagadpnldPLN-- 335
Cdd:TIGR00870 128 GITALHLAAHRQNYEIVKLLLERGASVParaCGDFFVKSQ-----GVDSFYHGES--------------------PLNaa 182

                         170       180
                  ....*....|....*....|....*.
gi 767946880  336 -CLlvavraNNYEIVRLLLSHGANVN 360
Cdd:TIGR00870 183 aCL------GSPSIVALLSEDPADIL 202
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 277-360 2.55e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 43.58  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 277 LELLIENGFDVN------TLLADHISQSYDDERKTAlyfgvsnndvHCTEVLLAAGADPNLDPLN------CLLVAVRAN 344
Cdd:PHA02989  53 VKLLIDNGADVNykgyieTPLCAVLRNREITSNKIK----------KIVKLLLKFGADINLKTFNgvspivCFIYNSNIN 122

                         90
                 ....*....|....*.
gi 767946880 345 NYEIVRLLLSHGANVN 360
Cdd:PHA02989 123 NCDMLRFLLSKGINVN 138
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 198-359 4.17e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.08  E-value: 4.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 198 SVLFEAAGGGNPDCISLLLEYGgSGNVPNRA--GHLPIHRAAYEGHYLALKYLI---PVTSKNAIRKS---GLTPIHSAA 269
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCP-SCDLFQRGalGETALHVAALYDNLEAAVVLMeaaPELVNEPMTSDlyqGETALHIAV 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 270 DGQNAQCLELLIENGFDVNTlladhisqsyddERKTALYFGVSNndvHCtevLLAAGADPnldplncLLVAVRANNYEIV 349
Cdd:cd22192   98 VNQNLNLVRELIARGADVVS------------PRATGTFFRPGP---KN---LIYYGEHP-------LSFAACVGNEEIV 152

                        170
                 ....*....|
gi 767946880 350 RLLLSHGANV 359
Cdd:cd22192  153 RLLIEHGADI 162
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 335-361 8.75e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 8.75e-04
                           10        20
                   ....*....|....*....|....*..
gi 767946880   335 NCLLVAVRANNYEIVRLLLSHGANVNC 361
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-293 4.14e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.84  E-value: 4.14e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880   2 IIPKGMDTNDDPDEDHLTSYDIQLSIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQEYVKYKYAMDEADEK 81
Cdd:COG0666    7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  82 GWFPLHEAVvqpiqqileivldavKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDG 161
Cdd:COG0666   87 GNTLLHAAA---------------RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDN 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 162 FGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGH 241
Cdd:COG0666  152 DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGN 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767946880 242 YLALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLAD 293
Cdd:COG0666  232 LEIVKLLLEAGADlNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
102-335 1.84e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 126.22  E-value: 1.84e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 102 LDAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEH 181
Cdd:COG0666   59 LAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 182 LIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIpvtSK----NAI 257
Cdd:COG0666  139 LLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL---EAgadvNAK 215

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767946880 258 RKSGLTPIHSAADGQNAQCLELLIENGFDVNTLladhisqsyDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN 335
Cdd:COG0666  216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAK---------DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
131-360 6.25e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 124.68  E-value: 6.25e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 131 WSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPD 210
Cdd:COG0666   22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 211 CISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI----PVtskNAIRKSGLTPIHSAADGQNAQCLELLIENGFD 286
Cdd:COG0666  102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLeagaDV---NAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767946880 287 VNTLladhisqsyDDERKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGANVN 360
Cdd:COG0666  179 VNAR---------DNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdnDGKTALDLAAENGNLEIVKLLLEAGADLN 246
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 485-540 6.10e-31

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 114.16  E-value: 6.10e-31
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767946880 485 ENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKL 540
Cdd:cd03731    1 ENPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQELKL 56
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-266 7.10e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.90  E-value: 7.10e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  53 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVvqpiqqileivldavKKGSYDMVSTLIKHNTSLDQPCVKRWS 132
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAA---------------YNGNLEIVKLLLEAGADVNAQDNDGNT 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 133 AMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCI 212
Cdd:COG0666  156 PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767946880 213 SLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIH 266
Cdd:COG0666  236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
177-392 1.86e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.94  E-value: 1.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 177 DVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI-PVTSKN 255
Cdd:COG0666    2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLaAGADIN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 256 AIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLladhisqsyDDERKTALYFGVSNNDVHCTEVLLAAGADPNL---D 332
Cdd:COG0666   82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR---------DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAqdnD 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767946880 333 PLNCLLVAVRANNYEIVRLLLSHGANVNcyfmHVNDTRFPSVIQYALNDEV-MLRLLLNNG 392
Cdd:COG0666  153 GNTPLHLAAANGNLEIVKLLLEAGADVN----ARDNDGETPLHLAAENGHLeIVKLLLEAG 209
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 115-397 2.40e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 81.25  E-value: 2.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 115 TLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHcdVLEHlihkggdvlalad 194
Cdd:PHA03100  20 YIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKY--NLTD------------- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 195 dgasvlfeaagggNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE--GHYLALKYLIPVTSK-NAIRKSGLTPIHSAADG 271
Cdd:PHA03100  85 -------------VKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANvNIKNSDGENLLHLYLES 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 272 --QNAQCLELLIENGFDVNT------LLADHISQSYDDER-KTALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLV 339
Cdd:PHA03100 152 nkIDLKILKLLIDKGVDINAknrvnyLLSYGVPINIKDVYgFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYgdtPLHI 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767946880 340 AVRANNYEIVRLLLSHGANVN---CYFMHVNDTRFPSVIQYAL-NDEVMLRLLLNNGYQVEM 397
Cdd:PHA03100 232 AILNNNKEIFKLLLNNGPSIKtiiETLLYFKDKDLNTITKIKMlKKSIMYMFLLDPGFYKNR 293
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 485-536 4.16e-16

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 72.57  E-value: 4.16e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767946880 485 ENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQ 536
Cdd:cd03730    1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKEYDLYGQ 52
Ank_2 pfam12796
Ankyrin repeats (3 copies);
200-289 1.68e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 1.68e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  200 LFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNaIRKSGLTPIHSAADGQNAQCLEL 279
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN-LKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|
gi 767946880  280 LIENGFDVNT 289
Cdd:pfam12796  80 LLEKGADINV 89
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 485-529 3.18e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 66.75  E-value: 3.18e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767946880 485 ENPCSLKHLCRLKIRRLMGLQKLCQpasVEKLPLPPAIQRYILFK 529
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLEL---IKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
134-226 1.32e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 1.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  134 MHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI-HKGGDVlalADDGASVLFEAAGGGNPDCI 212
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLeHADVNL---KDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 767946880  213 SLLLEYGGSGNVPN 226
Cdd:pfam12796  78 KLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
104-189 1.58e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 1.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  104 AVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHgGNVHLRDgFGVTPLGVAAEYGHCDVLEHLI 183
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLL 81


                  ....*.
gi 767946880  184 HKGGDV 189
Cdd:pfam12796  82 EKGADI 87
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 486-529 6.59e-13

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 62.87  E-value: 6.59e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767946880 486 NPCSLKHLCRLKIRRLMGLQKLCQpasVEKLPLPPAIQRYILFK 529
Cdd:cd03587    1 NPRSLQHLCRLAIRRCLGKRRLDL---IDKLPLPPRLKDYLLYK 41
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 104-290 1.08e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.08  E-value: 1.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 104 AVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMH----EAAKQGR-KDIVALLLKHGGNVHLRDGFGVTPLGVAA--EYGHC 176
Cdd:PHA03100  42 AKEARNIDVVKILLDNGADINSSTKNNSTPLHylsnIKYNLTDvKEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSY 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 177 DVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDC------------------ISLLLEYGGSGNVPNRAGHLPIHRAAY 238
Cdd:PHA03100 122 SIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVY 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767946880 239 EGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTL 290
Cdd:PHA03100 202 NNNPEFVKYLLDLgANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTI 254
Ank_2 pfam12796
Ankyrin repeats (3 copies);
233-331 3.82e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.44  E-value: 3.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  233 IHRAAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIEngfdvntlladHISQSYDDERKTALYFGV 311
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENgADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----------HADVNLKDNGRTALHYAA 69

                          90       100
                  ....*....|....*....|
gi 767946880  312 SNNDVHCTEVLLAAGADPNL 331
Cdd:pfam12796  70 RSGHLEIVKLLLEKGADINV 89
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 85-224 7.10e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 67.32  E-value: 7.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  85 PLHEAVVQPIQQILEIVLD-------------------AVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDI 145
Cdd:PHA02875  71 ELHDAVEEGDVKAVEELLDlgkfaddvfykdgmtplhlATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKG 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 146 VALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDG-ASVLFEAAGGGNPDCISLLLEYGGSGNV 224
Cdd:PHA02875 151 IELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGADCNI 230
Ank_2 pfam12796
Ankyrin repeats (3 copies);
265-360 7.85e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 7.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  265 IHSAADGQNAQCLELLIENGFDVNTLladhisqsyDDERKTALYFGVSNNDVHCTEVLLA-AGADPNLDPLNCLLVAVRA 343
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ---------DKNGRTALHLAAKNGHLEIVKLLLEhADVNLKDNGRTALHYAARS 71

                          90
                  ....*....|....*..
gi 767946880  344 NNYEIVRLLLSHGANVN 360
Cdd:pfam12796  72 GHLEIVKLLLEKGADIN 88
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 53-283 9.51e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.91  E-value: 9.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  53 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLD--------AVKKGSYDMVSTLIKHNTSLD 124
Cdd:PHA02874  39 LIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDngvdtsilPIPCIEKDMIKTILDCGIDVN 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 125 QPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVlehlihkggdvlaladdgasvlfeaa 204
Cdd:PHA02874 119 IKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDI-------------------------- 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 205 gggnpdcISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIR-KSGLTPIHSAADgQNAQCLELLIEN 283
Cdd:PHA02874 173 -------IKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKcKNGFTPLHNAII-HNRSAIELLINN 244
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 144-290 1.05e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.21  E-value: 1.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 144 DIVALLLKHGGNVHLRD-GFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSG 222
Cdd:PHA02878 148 EITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767946880 223 NVPNRAGHLPIHRAA-----YEGHYLALKYLIPVTSKNAIRksGLTPIHSAAdgQNAQCLELLIENGFDVNTL 290
Cdd:PHA02878 228 DARDKCGNTPLHISVgyckdYDILKLLLEHGVDVNAKSYIL--GLTALHSSI--KSERKLKLLLEYGADINSL 296
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 486-527 1.13e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 59.49  E-value: 1.13e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767946880  486 NPCSLKHLCRLKIRRLMGLQKLCQpasVEKLPLPPAIQRYIL 527
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 170-368 1.24e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.55  E-value: 1.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 170 AAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI 249
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 250 PVTS--KNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNT----------------------LLADHISQS--YDDER 303
Cdd:PHA02875  89 DLGKfaDDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIpntdkfsplhlavmmgdikgieLLIDHKACLdiEDCCG 168

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767946880 304 KTALYFGVSNNDVHCTEVLLAAGADPNLDPLN----CLLVAVRANNYEIVRLLLSHGANVNCYFMHVND 368
Cdd:PHA02875 169 CTPLIIAMAKGDIAICKMLLDSGANIDYFGKNgcvaALCYAIENNKIDIVRLFIKRGADCNIMFMIEGE 237
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 174-395 1.27e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.53  E-value: 1.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 174 GHCDVLEHLIHKGGDVLALA-DDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIpvt 252
Cdd:PHA02874  12 GDIEAIEKIIKNKGNCINISvDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI--- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 253 sKNAIRKSGLtPIHSAadgqNAQCLELLIENGFDVNTlladhisqsYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLD 332
Cdd:PHA02874  89 -DNGVDTSIL-PIPCI----EKDMIKTILDCGIDVNI---------KDAELKTFLHYAIKKGDLESIKMLFEYGADVNIE 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767946880 333 PLNC---LLVAVRANNYEIVRLLLSHGANVNcyfmhVNDTRFPSVIQYALN--DEVMLRLLLNNGYQV 395
Cdd:PHA02874 154 DDNGcypIHIAIKHNFFDIIKLLLEKGAYAN-----VKDNNGESPLHNAAEygDYACIKLLIDHGNHI 216
Ank_2 pfam12796
Ankyrin repeats (3 copies);
53-160 2.10e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 2.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880   53 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVvqpiqqileivldavKKGSYDMVSTLIKHNTSLDQpcVKRWS 132
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAA---------------KNGHLEIVKLLLEHADVNLK--DNGRT 63

                          90       100
                  ....*....|....*....|....*...
gi 767946880  133 AMHEAAKQGRKDIVALLLKHGGNVHLRD 160
Cdd:pfam12796  64 ALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 142-354 3.85e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.43  E-value: 3.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 142 RKDIVALLLKHGGNVHLRDGFGVTPLgvaaeygHC--------DVLEHLIHKGGDVLALADDGASVLFEAAGGGN--PDC 211
Cdd:PHA03095  62 VKDIVRLLLEAGADVNAPERCGFTPL-------HLylynattlDVIKLLIKAGADVNAKDKVGRTPLHVYLSGFNinPKV 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 212 ISLLLEYGGSGNVPNRAGHLPIH------RAAYEghylALKYLI----PVTSKNAIRKS--------------------- 260
Cdd:PHA03095 135 IRLLLRKGADVNALDLYGMTPLAvllksrNANVE----LLRLLIdagaDVYAVDDRFRSllhhhlqsfkprarivrelir 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 261 -----------GLTPIHSAADGQNAQCLEL--LIENGFDVNTLladhisqsyDDERKTALYFG-VSNNDVHCtEVLLAAG 326
Cdd:PHA03095 211 agcdpaatdmlGNTPLHSMATGSSCKRSLVlpLLIAGISINAR---------NRYGQTPLHYAaVFNNPRAC-RRLIALG 280

                        250       260       270
                 ....*....|....*....|....*....|.
gi 767946880 327 ADPNL---DPLNCLLVAVRANNYEIVRLLLS 354
Cdd:PHA03095 281 ADINAvssDGNTPLSLMVRNNNGRAVRAALA 311
PHA03095 PHA03095
ankyrin-like protein; Provisional
 144-359 4.13e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.05  E-value: 4.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 144 DIVALLLKHGGNVHLRDGFGVTPLGVaaeyghcdvlehLIHKGGDVLaladdgasvlfeaagggnPDCISLLLEYGGSGN 223
Cdd:PHA03095  28 EEVRRLLAAGADVNFRGEYGKTPLHL------------YLHYSSEKV------------------KDIVRLLLEAGADVN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 224 VPNRAGHLPIHraayegHYLALKYLIPVtsknairksgltpihsaadgqnaqcLELLIENGFDVNtlladhisqSYDDER 303
Cdd:PHA03095  78 APERCGFTPLH------LYLYNATTLDV-------------------------IKLLIKAGADVN---------AKDKVG 117

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767946880 304 KTAL--YFGVSNNDVHCTEVLLAAGADPN------LDPLNCLLVAVRAnNYEIVRLLLSHGANV 359
Cdd:PHA03095 118 RTPLhvYLSGFNINPKVIRLLLRKGADVNaldlygMTPLAVLLKSRNA-NVELLRLLIDAGADV 180
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 134-396 4.49e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.47  E-value: 4.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 134 MHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCIS 213
Cdd:PHA02876 149 IKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIK 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 214 LLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKsglTPIHSAADGQN-AQCLELLIENGFDVNtllA 292
Cdd:PHA02876 229 AIIDNRSNINKNDLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKN---TPLHHASQAPSlSRLVPKLLERGADVN---A 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 293 DHIsqsyddERKTALYFGVSNN-DVHCTEVLLAAGADPN------LDPLNclLVAVRANNYEIVRLLLSHGANVNcyfmh 365
Cdd:PHA02876 303 KNI------KGETPLYLMAKNGyDTENIRTLIMLGADVNaadrlyITPLH--QASTLDRNKDIVITLLELGANVN----- 369

                        250       260       270
                 ....*....|....*....|....*....|...
gi 767946880 366 VNDTRFPSVIQYAL--NDEVMLRLLLNNGYQVE 396
Cdd:PHA02876 370 ARDYCDKTPIHYAAvrNNVVIINTLLDYGADIE 402
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 101-249 1.39e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 61.04  E-value: 1.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 101 VLDAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLE 180
Cdd:PLN03192 529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767946880 181 HLIHkggdvLALADD---GASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI 249
Cdd:PLN03192 609 ILYH-----FASISDphaAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 488-529 1.09e-08

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 50.87  E-value: 1.09e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767946880   488 CSLKHLCRLKIRRLMGLqklcqpasVEKLPLPPAIQRYILFK 529
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--------IDKLPLPPRLKDYLLYY 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
130-183 2.53e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.35  E-value: 2.53e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767946880  130 RWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI 183
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 85-290 1.89e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.91  E-value: 1.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  85 PLHEAVVQP-----IQQILEIVLDA-------------VKKGSYDM--VSTLIKHNTSLDQPCVKRWSAMHEAAKQGR-K 143
Cdd:PHA02876 276 PLHHASQAPslsrlVPKLLERGADVnaknikgetplylMAKNGYDTenIRTLIMLGADVNAADRLYITPLHQASTLDRnK 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 144 DIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPdcisllleyggsgn 223
Cdd:PHA02876 356 DIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNP-------------- 421

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767946880 224 vpnraghlpihraayeghYLALKYLIP----VTSKNairKSGLTPIHSAADGQ-NAQCLELLIENGFDVNTL 290
Cdd:PHA02876 422 ------------------YMSVKTLIDrganVNSKN---KDLSTPLHYACKKNcKLDVIEMLLDNGADVNAI 472
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 485-529 2.66e-07

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 46.94  E-value: 2.66e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767946880 485 ENPCSLKHLCRLKIRRLMGLQKLCQpasVEKLPLPPAIQRYILFK 529
Cdd:cd03719    1 AEPHSLLHLSRLCVRHALGDTRLGQ---VSALPLPPAMKRYLLYQ 42
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 200-395 4.35e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.57  E-value: 4.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 200 LFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSgLTPIHSAADGQNAQCLEL 279
Cdd:PHA02878  41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYT-LVAIKDAFNNRNVEIFKI 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 280 LIENGFDVN----------------------TLLADH---ISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLdPL 334
Cdd:PHA02878 120 ILTNRYKNIqtidlvyidkkskddiieaeitKLLLSYgadINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNI-PD 198

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767946880 335 NC----LLVAVRANNYEIVRLLLSHGANVNCYFMHVNdTRFPSVIQYALNDEVmLRLLLNNGYQV 395
Cdd:PHA02878 199 KTnnspLHHAVKHYNKPIVHILLENGASTDARDKCGN-TPLHISVGYCKDYDI-LKLLLEHGVDV 261
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 487-529 7.54e-07

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 45.98  E-value: 7.54e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767946880 487 PCSLKHLCRLKIRRLMGLQKLcqPASVEKLPLPPAIQRYILFK 529
Cdd:cd03727    3 PGTLKALARYAVRRSLGVQYL--PEAVKQLPLPRSVKEYLLLL 43
Ank_4 pfam13637
Ankyrin repeats (many copies);
198-249 8.20e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.11  E-value: 8.20e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767946880  198 SVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI 249
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 110-236 8.89e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.42  E-value: 8.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 110 YDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAeyGHC---DVLEHLIHKG 186
Cdd:PHA02878 181 QRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYCkdyDILKLLLEHG 258

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767946880 187 GDVLALAD-DGASVLFEAAggGNPDCISLLLEYGGSGNVPNRAGHLPIHRA 236
Cdd:PHA02878 259 VDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADINSLNSYKLTPLSSA 307
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 485-527 1.03e-06

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 45.36  E-value: 1.03e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 767946880   485 ENPCSLKHLCRLKIRRLMGLQklcqpaSVEKLPLPPAIQRYIL 527
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTD------QIKTLPLPPKLKDYLS 41
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 487-529 3.65e-06

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 43.83  E-value: 3.65e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767946880 487 PCSLKHLCRLKIRRLMGLQKLcqpASVEKLPLPPAIQRYILFK 529
Cdd:cd03718    3 PLPLMDLCRRRVRVALGRDRL---EEIEQLPLPPSLKNYLLYQ 42
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 489-530 4.05e-06

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 44.01  E-value: 4.05e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767946880 489 SLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKE 530
Cdd:cd03722    5 SLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSD 46
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 486-527 5.98e-06

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 43.58  E-value: 5.98e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767946880 486 NPCSLKHLCRLKIRRLMGlqKLCQpASVEKLPLPPAIQRYIL 527
Cdd:cd03723    2 TPRSLQHLCRCAIRKLLG--SRCH-KLVPQLSLPTSLKNYLL 40
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 96-395 6.30e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.91  E-value: 6.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  96 QILEIVLDAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGH 175
Cdd:PHA02876 144 EYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 176 CDVLEHLIHKGGDV-------------------LALADDGASV----------LFEAAGGGN-PDCISLLLEYGGSGNVP 225
Cdd:PHA02876 224 IDTIKAIIDNRSNInkndlsllkairnedletsLLLYDAGFSVnsiddckntpLHHASQAPSlSRLVPKLLERGADVNAK 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 226 NRAGHLPIHRAAYEGHYLA-LKYLIPVTSK-NAIRKSGLTPIHSAAD-GQNAQCLELLIENGFDVNtlladhiSQSYDDe 302
Cdd:PHA02876 304 NIKGETPLYLMAKNGYDTEnIRTLIMLGADvNAADRLYITPLHQASTlDRNKDIVITLLELGANVN-------ARDYCD- 375

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 303 rKTALYFGVSNNDVHCTEVLLAAGADpnLDPLN-----CLLVAVRANN-YEIVRLLLSHGANVNCyfmhvNDTRFPSVIQ 376
Cdd:PHA02876 376 -KTPIHYAAVRNNVVIINTLLDYGAD--IEALSqkigtALHFALCGTNpYMSVKTLIDRGANVNS-----KNKDLSTPLH 447

                        330       340
                 ....*....|....*....|..
gi 767946880 377 YALNDEV---MLRLLLNNGYQV 395
Cdd:PHA02876 448 YACKKNCkldVIEMLLDNGADV 469
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 485-530 6.70e-06

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 43.32  E-value: 6.70e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767946880 485 ENPCSLKHLCRLKIRRLMGLQKLcqpASVEKLPLPPAIQRYILFKE 530
Cdd:cd03721    1 EPPRPLAHLCRLKVRTLIGINRI---KLIDTLPLPPRLIRYLNHQE 43
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 486-527 6.82e-06

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 43.18  E-value: 6.82e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767946880 486 NPCSLKHLCRLKIRRLMGLQKLcqpASVEKLPLPPAIQRYIL 527
Cdd:cd03720    2 NPRSLLSLCRIAVRRALGKQRL---SLICSLPLPDPIKKFLL 40
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 489-529 1.73e-05

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 41.72  E-value: 1.73e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767946880 489 SLKHLCRLKIRRLMGLQKlcqpasVEKLPLPPAIQRYILFK 529
Cdd:cd03746    5 SLQHLCRMAIRRVMPTQQ------VKELPIPSKLLEFLTYR 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 65-189 2.02e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.56  E-value: 2.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  65 LQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVL------------------DAVKKGSYDMVSTLIkHNTSLDQP 126
Cdd:PLN03192 541 LEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLkhacnvhirdangntalwNAISAKHHKIFRILY-HFASISDP 619

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767946880 127 CVKRwSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDV 189
Cdd:PLN03192 620 HAAG-DLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 196-360 2.61e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.00  E-value: 2.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  196 GASVLFEAAGGGNP-DCISLLLEYGGSGNVpnraGHLPIHRAA---YEGHYLALKYLIPVTSK-------NAIRKS---- 260
Cdd:TIGR00870  52 GRSALFVAAIENENlELTELLLNLSCRGAV----GDTLLHAISleyVDAVEAILLHLLAAFRKsgplelaNDQYTSeftp 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  261 GLTPIHSAADGQNAQCLELLIENGFDVN---TLLADHISQsyddeRKTALYFGVSnndvhctevllaagadpnldPLN-- 335
Cdd:TIGR00870 128 GITALHLAAHRQNYEIVKLLLERGASVParaCGDFFVKSQ-----GVDSFYHGES--------------------PLNaa 182

                         170       180
                  ....*....|....*....|....*.
gi 767946880  336 -CLlvavraNNYEIVRLLLSHGANVN 360
Cdd:TIGR00870 183 aCL------GSPSIVALLSEDPADIL 202
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 489-529 3.10e-05

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 41.25  E-value: 3.10e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767946880 489 SLKHLCRLKIRRLMGLQKlcqpasVEKLPLPPAIQRYILFK 529
Cdd:cd03733    5 SLQHLCRMALRRVMTTQQ------VLALPIPKKMKEFLTYR 39
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 489-531 3.39e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 41.04  E-value: 3.39e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767946880 489 SLKHLCRLKIRRLMGLQKlcqpasVEKLPLPPAIQRYIlfKEY 531
Cdd:cd03717    5 SLQHLCRFVIRQCTRRDL------IDQLPLPRRLKDYL--KEY 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 85-189 6.45e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.43  E-value: 6.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  85 PLHEAVVQPIQQiLEIVLDAVKKGSY----DMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRD 160
Cdd:PHA03100 144 LLHLYLESNKID-LKILKLLIDKGVDinakNRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVN 222

                         90       100
                 ....*....|....*....|....*....
gi 767946880 161 GFGVTPLGVAAEYGHCDVLEHLIHKGGDV 189
Cdd:PHA03100 223 KYGDTPLHIAILNNNKEIFKLLLNNGPSI 251
Ank_4 pfam13637
Ankyrin repeats (many copies);
261-323 7.44e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 7.44e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767946880  261 GLTPIHSAADGQNAQCLELLIENGFDVNTLladhisqsyDDERKTALYFGVSNNDVHCTEVLL 323
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAV---------DGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
232-281 8.45e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 8.45e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767946880  232 PIHRAAYEGHYLALKYLI----PVtskNAIRKSGLTPIHSAADGQNAQCLELLI 281
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLekgaDI---NAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
163-216 1.15e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 1.15e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767946880  163 GVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLL 216
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 277-360 2.55e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 43.58  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 277 LELLIENGFDVN------TLLADHISQSYDDERKTAlyfgvsnndvHCTEVLLAAGADPNLDPLN------CLLVAVRAN 344
Cdd:PHA02989  53 VKLLIDNGADVNykgyieTPLCAVLRNREITSNKIK----------KIVKLLLKFGADINLKTFNgvspivCFIYNSNIN 122

                         90
                 ....*....|....*.
gi 767946880 345 NYEIVRLLLSHGANVN 360
Cdd:PHA02989 123 NCDMLRFLLSKGINVN 138
Ank_5 pfam13857
Ankyrin repeats (many copies);
149-200 4.08e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.48  E-value: 4.08e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767946880  149 LLKHGG-NVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVL 200
Cdd:pfam13857   1 LLEHGPiDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 198-359 4.17e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.08  E-value: 4.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 198 SVLFEAAGGGNPDCISLLLEYGgSGNVPNRA--GHLPIHRAAYEGHYLALKYLI---PVTSKNAIRKS---GLTPIHSAA 269
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCP-SCDLFQRGalGETALHVAALYDNLEAAVVLMeaaPELVNEPMTSDlyqGETALHIAV 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 270 DGQNAQCLELLIENGFDVNTlladhisqsyddERKTALYFGVSNndvHCtevLLAAGADPnldplncLLVAVRANNYEIV 349
Cdd:cd22192   98 VNQNLNLVRELIARGADVVS------------PRATGTFFRPGP---KN---LIYYGEHP-------LSFAACVGNEEIV 152

                        170
                 ....*....|
gi 767946880 350 RLLLSHGANV 359
Cdd:cd22192  153 RLLIEHGADI 162
PHA03095 PHA03095
ankyrin-like protein; Provisional
 97-217 7.30e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.32  E-value: 7.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  97 ILEIVLDAVKKgSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQG--RKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYG 174
Cdd:PHA03095 190 LLHHHLQSFKP-RARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFN 268

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 767946880 175 HCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLE 217
Cdd:PHA03095 269 NPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALA 311
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 335-361 8.75e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 8.75e-04
                           10        20
                   ....*....|....*....|....*..
gi 767946880   335 NCLLVAVRANNYEIVRLLLSHGANVNC 361
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 7-200 1.17e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 41.67  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880   7 MDTNDDPDEDHL-TSYDIQLSIQESIEASKTALCPERFVPLSAQNRKLVEAIKQGHIPELQEYVKYK------------- 72
Cdd:cd22194    2 MDSNIRQCPSGNcDDMDSPQSPQDDTPSNPNSPSAELAKEEQRDKKKRLKKVSEAAVEELGELLKELkdlsrrrrktdvp 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880  73 -YAMDE--ADEKGWFPLHEAVVQPIQQILEIV--LDAVKKGSyDMVSTLIkhNTSLDQPCVKRWSAMHEAAKQGRKDIVA 147
Cdd:cd22194   82 dFLMHKltASDTGKTCLMKALLNINENTKEIVriLLAFAEEN-GILDRFI--NAEYTEEAYEGQTALNIAIERRQGDIVK 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767946880 148 LLLKHGGNVHLR------------DG--FGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADD-GASVL 200
Cdd:cd22194  159 LLIAKGADVNAHakgvffnpkykhEGfyFGETPLALAACTNQPEIVQLLMEKESTDITSQDSrGNTVL 226
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 277-395 1.76e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 40.88  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 277 LELLIENGFDVNTlladhisqSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLD-----PLNCLLvavraNNYEI--- 348
Cdd:PHA02989  19 LEFLLRTGFDVNE--------EYRGNSILLLYLKRKDVKIKIVKLLIDNGADVNYKgyietPLCAVL-----RNREItsn 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767946880 349 -----VRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQV 395
Cdd:PHA02989  86 kikkiVKLLLKFGADINLKTFNGVSPIVCFIYNSNINNCDMLRFLLSKGINV 137
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 109-217 1.87e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 40.88  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 109 SYDMVSTLIKHNTSLDQPcvkrwSAMHEAAKQG---------RKDIVAL--LLKHGgNVHLRDGFGVTPLGVAAEYGHCD 177
Cdd:PHA02989 197 SIKVIKYLIKKGVNIETN-----NNGSESVLESfldnnkilsKKEFKVLnfILKYI-KINKKDKKGFNPLLISAKVDNYE 270

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767946880 178 VLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLE 217
Cdd:PHA02989 271 AFNYLLKLGDDIYNVSKDGDTVLTYAIKHGNIDMLNRILQ 310
Ank_4 pfam13637
Ankyrin repeats (many copies);
98-150 2.29e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 2.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767946880   98 LEIVLDAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLL 150
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
116-170 2.92e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 2.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767946880  116 LIKHNT-SLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVA 170
Cdd:pfam13857   1 LLEHGPiDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 489-531 3.19e-03

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 35.71  E-value: 3.19e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767946880 489 SLKHLCRLKIRRLMglqklcqpASVEKLPLPPAIQRYIlfKEY 531
Cdd:cd03734    5 SLQHLCRLVINRLV--------TDVDCLPLPRRMADYL--RQY 37
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 266-355 5.35e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 5.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 266 HSAADGqNAQCLELLIENGFDVNtlladhiSQSYDDerKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVR 342
Cdd:PTZ00322  88 QLAASG-DAVGARILLTGGADPN-------CRDYDG--RTPLHIACANGHVQVVRVLLEFGADPTLldkDGKTPLELAEE 157

                         90
                 ....*....|...
gi 767946880 343 ANNYEIVRLLLSH 355
Cdd:PTZ00322 158 NGFREVVQLLSRH 170
PHA02730 PHA02730
ankyrin-like protein; Provisional
 275-380 6.42e-03

ankyrin-like protein; Provisional


Pssm-ID: 165098 [Multi-domain]  Cd Length: 672  Bit Score: 39.24  E-value: 6.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767946880 275 QCLELLIENGFDVNTLLADHISQsYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAV------RANNYEI 348
Cdd:PHA02730 435 HCYETILIDVFDILSKYMDDIDM-IDNENKTLLYYAVDVNNIQFARRLLEYGASVNTTSRSIINTAIqkssyrRENKTKL 513

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767946880 349 VRLLLSH---------GANVNCYFMH------------VNDTRFPSVIQYALN 380
Cdd:PHA02730 514 VDLLLSYhptletmidAFNRDIRYLYpepllaciryalILDNDFPSKVKYDIA 566
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 131-160 7.96e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.19  E-value: 7.96e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 767946880  131 WSAMHEAAKQ-GRKDIVALLLKHGGNVHLRD 160
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH